A study published on March 21 in Stem Cells Translational Medicine reports on a new method for generating large numbers of skeletal muscle cells and myogenic progenitors from human embryonic stem cells (hESC). Researchers in Masatoshi Suzuki’s Laboratory at the University of Wisconsin-Madison School of Veterinary Medicine have developed a new protocol to derive myogenic progenitors and differentiated muscle cells from hESCs using free-floating spherical cultures in the presence of specific growth factors. The major advantage of this method is that it does not require genetic modification of the cells, and yields a higher percentage of partially and fully differentiated muscle cells than other methods. In addition, this method can be used to generate muscle cells from induced pluripotent stems cells originating from ALS patients or patients with other neuromuscular disorders, providing a useful in vitro platform for drug research. Click here to read more.
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