ADNI: GWA Nearly Complete, Biomarker Analysis Update

The Alzheimer’s Disease Neuroimaging Initiative announced this week that its genomewide analysis is 95 percent complete. ADNI is a collaborative project studying more than 800 people who have AD, mild cognitive impairment, or neither in the case of control subjects (see ARF related news story). The multisite, $60 million project, funded by the National Institutes of Health and the private sector, aims to integrate brain imaging, biochemistry, neuropsychological assessment, and genetics to identify biomarkers to diagnose and track the development of AD.

It’s a landmark dataset that I think is likely to have a very high impact, said Andrew Saykin of the Indiana University School of Medicine, leader of the ADNI genetic team. The genetics portion of the study read more than 620,000 DNA markers, and scientists will be able to look for genetic correlations with all of ADNI’s other data. There’s an incredibly rich phenotypemuch more than the presence or absence of disease, Saykin said. The ADNI data will be available online to qualified scientists. Saykin expects to complete the last samples within two or three months, and to present preliminary results at the International Conference on Alzheimer’s Disease this summer.

Also this week, ADNI scientists published results from cerebrospinal fluid analyses of 416 subjects in the 18 March Annals of Neurology online. The authors define threshold values for cerebrospinal amyloid-β and tau that are associated with disease, but, equally importantly, they present standardized methods for collecting and storing samples and for measuring protein levels. Because ADNI encompasses 59 centers, an essential part of the project is to make sure everyone does the same experiments the same way. The need for standardization is great, because we’re dealing with small changes over time, said first author Leslie Shaw of the University of Pennsylvania in Philadelphia. We hope this will benefit future clinical trials as a standard setting.

Shaw LM, Vanderstichele H, Knapik-Czajka M, Clark CM, Aisen PS, Petersen RC, Blennow K, Soares H, Simon A, Lewczuk P, Dean R, Siemers A, Potter W, Lee VM-Y, Trojanowski J, ADNI. Annal Neurol 2009 March 18 online. Abstract

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