Drug Name: TDI-846
Company: ALS Therapy Development Institute
Location: US-Massachusetts
Drug Type: Protein Biologic
Conditions: ALS
Mechanism Type: Immunomodulation
Mechanism: TDI-846 (blocking antibody to CD40L) is designed to modulate the immune response associated with disease progression in ALS.
U.S. Status for ALS: Preclinical

[1] From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis. Lincecum JM et al. Nat Genet. 2010 May;42(5):392-9.
[2] AntiCD40L (TDI28). ALS Therapy Development Institute, 2016. Accessed 9 Mar 2016 from

Last updated March 9th, 2016

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