Blocking Axon Destruction Delays Death in ALS Mice

Last summer we covered exciting results out of the laboratory of Dr. Marc Freeman, professor of neurobiology at the University of Massachusetts Medical, which showed that Wallerian degeneration is an active axonal death process driven by dSarm in Drosophila and Sarm1 in mice. Now, Dr. Freeman and his team have made another exciting advance that may one day impact people with ALS. The researchers discovered that ALS mice harboring a mutation in the Sarm1 gene survived 10 days longer than ALS mice with a functional Sarm1 and showed a significant increase in motor neuron survival. Click here to read the full story and find out why this could be a promising finding for people with ALS.

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