In NFL Players, Brain Inflammation May Persist Years After Head Trauma

Research has shown that sports-related head injuries lead to future amyloid and tau pathology, as well as a higher risk of dementia and neuropsychiatric symptoms. However, the link between traumatic brain injury (TBI) and these ensuing problems is unclear. Could inflammation play a role? Scientists led by Martin Pomper, Johns Hopkins Medical Institutions, Baltimore, report […]

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Muscle-derived FGFBP1 Helps Preserve Neuromuscular Junction Integrity, but Fails in ALS

Transforming growth factor beta (TGF-β1) released by astrocytes has been implicated in mediating motor neuron death in ALS (see Apr 2015 news). Now, it is resurfacing as an agent of destruction through another avenue: it contributes to neuromuscular junction (NMJ) abnormalities in ALS. According to a paper in the November 14 Journal of Neuroscience, muscle […]

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More Evidence That Distinct Tau Strains May Cause Different Tauopathies

From corticobasal degeneration to frontotemporal dementia, tauopathies come in many guises. How disruptions in a single protein cause such varied diseases remains a mystery. Results from a new study support the idea that unique conformations of misfolded tau may be to blame. Researchers led by Marc Diamond of the University of Texas Southwestern Medical Center […]

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