At AAN, Sights Set on Antisense Therapies for Diseases of the Brain

In recent years, two antisense oligonucleotide therapies have hit the market, at least nine more are in clinical trials for the treatment of neurologic diseases, and nearly two dozen are in preclinical testing, including ASOs for Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, frontotemporal dementia, spinocerebellar ataxias, pain, and rare disorders. At the 70th annual meeting of […]

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Oligodendrocytes Seem to Imprint Specific Alter Ego on α-Synuclein

You can take the protein out of the oligodendrocyte, but you can’t take the oligodendrocyte out of the protein. In the May 9 Nature, researchers led by Virginia Lee at the University of Pennsylvania, Philadelphia, make the claim that cell type determines which sort of toxic strain α-synuclein will become. The scientists compared neuronal α-synuclein […]

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