Cellular Chaperones Potentially Important for Preventing Neuronal Toxicity in ALS

In a recent study published in PNAS, researchers from the University of Illinois at Chicago, Yale University, and Harvard University showed that chaperones can prevent the neuronal death associated with dysregulated axonal transport in ALS. Using nerves isolated from giant squid, the researchers were able to show that to some extent Hsc70 and to an even greater extent Hsp110 (in substoichiometric amounts) could rescue axonal transport defects caused by aggregates of mutant SOD1. Click here to read more.


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