Drug Name: GDC-0134
Company: Genentech
Location: US-California
Drug Type: Unknown
Conditions: ALS
Mechanism Type: Glutamate Excitotoxicity Blocker
Mechanism: GDC-0134 is an inhibitor of the dual leucine zipper kinase (DLK). It aims to promote survival of motor neurons in ALS by reducing glutamate-mediated excitotoxicity.
U.S. Status for ALS: Phase I

[1] Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. Le Pichon, CE et al. Sci Transl Med. 2017 Aug 16;9(403). pii: eaag0394.
[2] Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration. Pozniak, CD et al. J Exp Med. 2013 Nov 18;210(12):2553-67.
[3] A Single-Ascending-Dose Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Patients With Amyotrophic Lateral Sclerosis., 1 Feb 2016. Accessed 11 Mar 2016 from

Last updated February 8th, 2018

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