Hypertension Drug May Reduce Risk of ALS

A new study suggests that angiotensin-converting enzyme inhibitors (ACEIs), widely prescribed medications for treating high blood pressure and coronary artery disease, may also dramatically reduce the risk of ALS. The study, published on Nov 10 in JAMA Neurology online by Charles Tzu-Chi Lee of the Kaohsiung Medical University, Kaohsiung, Taiwan and colleagues, was based on data from the whole Taiwanese population seen in medical practice, and included data from 729 ALS patients and almost 15 thousand controls. ALS Patients who had received ACEIs at a greater than 449.5 cumulative defined daily dose in four years had a 57% lower risk of ALS. These findings provide a promising lead that will need to be further validated in additional animal and clinical studies.

A new study suggests that angiotensin-converting enzyme inhibitors (ACEIs), widely prescribed medications for treating high blood pressure and coronary artery disease, may also dramatically reduce the risk of ALS. The study, published on Nov 10 in JAMA Neurology online by Charles Tzu-Chi Lee of the Kaohsiung Medical University, Kaohsiung, Taiwan and colleagues, was based on data from the whole Taiwanese population seen in medical practice, and included data from 729 ALS patients and almost 15 thousand controls. ALS Patients who had received ACEIs at a greater than 449.5 cumulative defined daily dose in four years had a 57% lower risk of ALS. These findings provide a promising lead that will need to be further validated in additional animal and clinical studies.

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