TANA inhibitors

Drug Name: TANA inhibitors
Company: ImStar Therapeutics
Location: Canada
Website: http://www.imstartx.com/
Drug Type: Protein Biologic
Conditions: ALS
Mechanism Type: Immunomodulation
Mechanism: TDP-43 abnormally accumulates aggregates in the cytoplasm of the vast majority of ALS patients. In addition, recent studies have shown that TDP-43 activates NFkB, and may increase inflammation via this pathway. This approach, known as TDP-43-associated nuclear factor-kB (NFkB) activation (TANA) inhibitors, aims to reduce neuroinflammation by targeting this pathway.
U.S. Status for ALS: Preclinical

References:
[1] ImStar Therapeutics. Pipeline. ImStar Therapeutics, n.d. Pipeline. Accessed 9 Mar 2016 from http://imstartx.com/pipeline.html.
[2] Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor kappaB-mediated pathogenic pathways. Swarup, V et al. J Exp Med. 2011 No 21;208(12):2429-47.

Last updated February 14th, 2018

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