123C4

Drug Name: 123C4
Company: Iron Horse Therapeutics
Location: US-California
Website: http://www.coipharma.com/portfolio/
Drug Type: Small molecule
Conditions: ALS
Mechanism Type: Axon regeneration
Mechanism: 123C4 may help facilitate the repair of damaged motor neuronal axons by blocking EphA4-mediated signaling. The drug, which acts as an EphA4 agonist, may remove EphA4 from motor neuron surfaces by receptor-mediated endocytosis.
U.S. Status for ALS: Preclinical

References:
[1] Potent and Selective EphA4 Agonists for the Treatment of ALS. Wu, B. et al. Cell Chemical Biology. Published online February 9, 2017.

Last updated March 8th, 2017

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