ISIS Initiates Phase 1 Clinical Trial of ISIS-SOD1Rx in Patients With ALS

Isis Pharmaceuticals has initiated a Phase 1 study of ISIS-SOD1Rx in patients with an inherited, aggressive form of ALS. About 20% of inherited ALS cases are caused by a mutant form of the SOD1 gene–ISIS-SOD1Rx is therefore designed to reduce the body’s production of SOD1. The trial is supported in part by the ALS Association and the MDA.

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