Looking Back at Advances in ALS for 2013

The ALSTDI has created an engaging and interactive timeline of last year’s key milestones in ALS research and development. The summary covers notable therapies in clinical development and new treatment strategies, including antibodies targeting misfolded SOD1, small molecules to reduce neuroinflammation in motor nerves, and adult stem cells derived from patients’ bone marrow to secrete neuroprotective substances. Technologies and devices that may aid diagnosis and prediction are also on list. For example, electromyography (EMG) to improve diagnosis by checking for subclinical signs of ALS, a whole-brain magnetic resonance technique as a quantifiable neuroimaging marker for ALS, and an ALS cognitive test.

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