Drug Name: NI-205
Company: Neurimmune Therapeutics
Location: Switzerland
Drug Type: Protein Biologic
Conditions: ALS, frontotemporal dementia, Alzheimer’s disease
Mechanism Type: Protein aggregate clearance, TDP-43
Mechanism: NI-205 is a human-derived monoclonal antibody that targets TDP-43. Pathological cytoplasmic aggregates of TDP-43 are a hallmark of ALS and ALS/frontotemporal dementia, and mutations in the gene are associated with both diseases.
U.S. Status for ALS: Preclinical

[1] Neurimmune – Product Pipeline. Neurimmune. Product Pipeline. Accessed 11 Mar 2016 from
[2] NeurImmune allies with Biogen. European Biotechnology. NeurImmune allies with Biogen. 2 Jun 2011. Accessed 11 Mar 2016 from

Last updated March 11th, 2016

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