Drug Name: NT-KO-003
Company: Neurotec Pharma
Location: Spain
Website: http://www.neurotec-pharma.com
Drug Type: Small Molecule
Conditions: ALS, multiple sclerosis, stroke
Mechanism Type: Immunomodulation
Mechanism: NT-K0-003 is a small molecule modulator of microglial activity that confers neuroprotection according to preclinical studies. The compound, also known as diazoxide, is a K-ATP potassium channel activator that may reduce inflammation by blocking microglial activation.
U.S. Status for ALS: Preclinical

[1] Diazoxide For Use In The Treatment Of Amyotrophic Lateral Sclerosis (ALS). FreePatentsOnline, 6 June 2013. Accessed 11 March, 2016 from http://www.freepatentsonline.com/y2013/0143873.html
[2] Effects of diazoxide in multiple sclerosis: A randomized, double-blind phase 2 clinical trial. Villoslada, P. et al. Neurol Neuroimmunol Neuroinflamm. 2015 Sep 10;2(5):e147.
[3] A Phase IIa Study of NT-KO-003 for Multiple Sclerosis ClinicalTrials.gov, 14 March, 2014. Accessed 11 March 2016 from https://clinicaltrials.gov/ct2/show/NCT01428726

Last updated March 8th, 2019

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