Dr. Paola Arlotta, an associate professor in the Department of Stem Cell and Regenerative Biology at Harvard, and her postdoc, Dr. Caroline Rouaux, recently discovered that it is possible to reprogram callosal projection neurons into neurons phenotypically similar to corticospinal motor neurons. Corticospinal motor neurons are one of the two types of neurons that progressively degenerate in people with ALS. Drs. Arlotta and Rouaux reprogrammed these neurons in the brains of live mice using the Fezf2 transcription factor. This work was recently published online in Nature Cell Biology. Read more about this intriguing approach here.
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