Not Disclosed

Drug Name: Not Disclosed
Company: OptiKira
Location: US-California
Drug Type: Small Molecule
Conditions: ALS, diabetes, retinitis pigmentosa
Mechanism Type: Unfolded protein response (UPR), IRE1 alpha inhibitor
Mechanism: OptiKira is developing inhibitors of the unfolded protein response, specifically of inositol-requiring enzyme-1 alpha (IRE1α), a key activation step in the unfolded protein response (UPR). The technology has applications for ALS, although the company’s current focus is diabetes and retinitis pigementosa.
U.S. Status for ALS: Preclinical

[1] OptiKira, a New Biotech Start-up, Created to Develop Drugs to Prevent Cell Death Caused by the Unfolded Protein Response. PR Newswire, 2 Feb 2015. Accessed 11 Mar 2016 from

Last updated March 11th, 2019

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