Applications are invited for a Research Fellow based in the laboratory of Dr Rickie Patani at the UCL Queen Square Institute of Neurology and the Francis Crick Institute. The lab carries out internationally competitive research into the molecular mechanisms underpinning Motor Neuron Disease (ALS), with a particular focus on deregulated RNA metabolism. The appointee will join a team of researchers working on various aspects of cellular and molecular neuropathology. Our lab has significant experience with human pluripotent stem cell (hPSC) culture, directed differentiation to clinically relevant populations of neurons and glia, and in vitro disease modelling focusing on post-transcriptional mechanisms of disease (eg, Hall et al, Cell Reports 2017; Luisier et al, Nature Comunications 2018). We work with several human induced pluripotent stem cell (hiPSC) lines carrying MND-causing mutations (including VCP, SOD1, FUS, TDP-43, C9ORF72). Through an ongoing close collaboration with Jernej Ule and Nicholas Luscombe, we use novel functional genomic methodologies to molecularly interrogate hiPSC-based in vitro models of neurodegeneration, with a particular focus on aberrant intron retention and other forms of alternative splicing. The mechanistic insights that emerge from this project will be used as a platform for drug screening to identify potentially novel therapies for ALS.
Employer: University College London
Location: London, England
Degree required: PhD
Job posted: April 16th, 2019