Figure 3. SUMOs colocalize with familial ALS-linked SOD1 mutants in intracellular aggregates.
Image credit: Niikura, et. al. 2014 under CC BY license

Job Opportunities

To submit any new job opportunities for this list, please email ALSjobs@prize4life.org. List the employer, location, closing date if applicable, and a link to more information. Jobs are removed after 3 months, unless requested otherwise.

This free job bulletin board aims to help scientists identify job opportunities in the field of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Positions described as broadly spanning neurodegenerative diseases (NDG) are noted as ‘NDG‘. The job listing includes research positions at all levels, as well as non-research positions for which a research background at the MS, PhD, or MD level is required.


Click the title of any table column to sort.

Academia

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Postdoctoral Fellow, Meyer Lab

Postdoctoral Fellow, Meyer Lab

(Click title to open job details in a new window.)
Description:

The Meyer laboratory is focusing on research in life-threatening Neurodegenerative and Neurological Disorders such as Amyotrophic Lateral Sclerosis and Spinal Muscular Atrophy, Rett Syndrome and Batten Disease. We investigate disease mechanisms using state-of-the-art in vitro models and reprogramming techniques. Our efforts are motivated by finding a treatment that can be translated to the clinic. Using gene therapy, we have successfully translated several of our approaches to the clinic and continue to work hand-in-hand with clinicians at the hospital to move additional programs forward.


Our laboratory is looking for a highly motivated, team-oriented post-doctoral researcher preferably with experience in tissue sectioning and staining methods. The position does not require a background in gene therapy, but experience in working with animals models are an advantage. The candidate works under the mentorship of an established CRI principal investigator or Senior Research Scientists to design experiments and develop protocols to conduct research in the field of gene therapy. From the results of studies, the candidate helps to develop hypotheses for further investigation. Moreover, he/she prepares technical materials such as abstracts, annual reports, scientific papers and presentations. The candidate works toward a goal of becoming independent in his/her research effort, and eventually obtaining external research funding. Appointment as a Post Doc is a maximum of 5 years in length.


Link: https://careerspace.nationwidechildrens.org/ltm/CandidateSelfService/controller.servlet?context.dataarea=ltm&webappname=CandidateSelfService&HROrganization=10&JobReq=17924&JobPost=3&context.session.key.HROrganization=10&context.session.key.JobBoard=EXTERNAL&context.session.key.HROrganization=[Client%20Specific%20Code]&context.session.key.JobBoard=EXTERNAL&context.session.key.HROrganization=[Client%20Specific%20Code]&context.session.key.JobBoard=EXTERNAL#
Employer: Nationwide Children's Hospital
Location: Columbus, OH
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: February 21st, 2018
Nationwide Children's HospitalColumbus, OHPhDALSFeb 21, 2018
NEW! Postdoctoral Fellow, Khurana Lab

Postdoctoral Fellow, Khurana Lab

(Click title to open job details in a new window.)
Description:

One postdoctoral position is available in the Khurana laboratory (khuranalab.bwh.harvard.edu) at Harvard Medical School and Brigham and Women’s Hospital.


The Khurana laboratory uses cutting edge stem cell, genome-editing and in situ proteomic techniques to study the protein-misfolding pathologies that underlie neurodegenerative disease (Chung, Khurana et al. Science 2013; Khurana, Peng, Chung et al. Cell Systems 2017; Khurana and Jarosz Cell 2017).


We now have an opening for a postdoctoral Fellow to push forward our efforts to genetically and physically map interactions of misfolded proteins in patient-derived neurons. We are keen to attract motivated, open-minded and collaborative applicants with experience in advanced cell culture and molecular biology techniques. Human stem cell experience, genome editing experience and solid biochemistry background would be advantageous.


We strive for impactful science in a collaborative and collegial environment. We consider career development in basic science and translational medicine core to our mission. Our postdoctoral fellows will fully benefit from the deep connections to premier academic labs, hospitals and biotech companies that we have established in the extraordinary Boston biomedical environment. The lab is located in the new Building for Transformative Medicine, housing state-of-the-art laboratory and clinical facilities adjacent to Brigham and Women’s Hospital and Harvard Medical School.


Our salary and benefits package will be highly competitive and commensurate with the cost of living. Brigham and Women’s Hospital and Harvard Medical School are Equal Opportunity Employers. Please email a cover letter, your CV, and contact details for three references to Vik Khurana MD PhD (vkhurana@bwh.harvard.edu) and Joan Swan (jhswan@rics.bwh.harvard.edu).



Link: https://www.nature.com/naturejobs/science/jobs/637343-postdoctoral-fellowship
Employer: Brigham and Women's Hospital
Location: Boston, MA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: February 20th, 2018
Brigham and Women's HospitalBoston, MAPhDNDGFeb 20, 2018
NEW! Postdoctoral Fellow, Heutink Lab

Postdoctoral Fellow, Heutink Lab

(Click title to open job details in a new window.)
Description:

A position for a post-doctoral researcher is available from 01.03.2018 within the scientific team “Genome Biology of Neurodegenerative Diseases” led by Prof. Peter Heutink in Tübingen.


The research focus of our group is to identify genetic risk factors for neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Frontal-Temporal Dementia/Motor Neuron Disease, Progressive Supranuclear Palsy and Ataxia in close collaboration with our clinical partners. As partners in the International Parkinson’s Disease Genomics Consortium (IPDGC) (http://pdgenetics.org/) we participate in large scale genetic studies to identify new genetic risk factors and to characterize the biological consequences of these mutations and risk factors by using automated high-throughput cellular screens combined with genomic and transcriptomic approaches. For further details on the scientific program of the group please refer to http://www.dzne.de/en/sites/tuebingen/research-groups/heutink.html.


Applications should contain the following documents (in English):

·A detailed Curriculum Vitae

·A motivation letter, including a brief description of past research experience and future interests

·Copies of degrees

·Name and contact details of at least two referees


Link: https://jobs.dzne.de/de/jobs/151/postdoctoral-researcher-fm-303720181
Employer: German Center for Neurodegenerative Diseases (DZNE)
Location: Tübingen, Germany
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: February 16th, 2018
German Center for Neurodegenerative Diseases (DZNE)Tübingen, GermanyPhDALS, FTDFeb 16, 2018
NEW! Postdoctoral Fellow, Hickman and Shuler Labs

Postdoctoral Fellow, Hickman and Shuler Labs

(Click title to open job details in a new window.)
Description:

This post doctoral research opportunity focuses combining microfabrication and cell culture to construct in vitro models of the human body or “Body-on-a-Chip” for use in drug development. Multiple organs and their physiological interactions are represented on a single device; these interactions are based on physiologically based pharmacokinetic models. Of particular interest will be to combine metabolically active tissue, such as from the liver, with electrically active tissues such as cardiac myocytes or neuronal cells and then conduct pharmacological studies in this system.


This project is joint between the laboratories of J. Hickman ( UCF ) and Mike Shuler (Cornell) and the student is expected to move between sites as necessary, but will spend the majority of time at UCF . Reimbursement for travel expenses will be provided and the successful candidate will have access to facilities in both universities.


Minimum Qualifications

A bachelor’s degree in an appropriate area of specialization and four years of appropriate experience. Appropriate college coursework may substitute at an equivalent rate for the required experience. If minimum requirements of the position do not require post high school education, an applicant is not required to provide the information on the application.


Additional Minimum Requirements


Preferences

A PhD. in biomedical engineering/pharmacology/material science or related field is expected. Basic knowledge of techniques for microfabrication and/or cell culture is highly desirable. To apply please upload curriculum vitae, a brief description of prior research experience and the names and contact information of three referees to jobswithucf.com


Link: https://www.jobswithucf.com/postings/51294
Employer: University of Central Florida
Location: Orlando, FL
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: February 16th, 2018
University of Central FloridaOrlando, FLPhDALSFeb 16, 2018
NEW! Research Associate, Meyer Lab

Research Associate, Meyer Lab

(Click title to open job details in a new window.)
Description:

They Meyer laboratory is focusing on research in life-threatening Neurodegenerative and Neurological Disorders such as Amyotrophic Lateral Sclerosis and Spinal Muscular Atrophy, Rett Syndrome and Batten Disease. We investigate disease mechanisms using state-of-the-art in vitro models and reprogramming techniques. Our efforts are motivated by finding a treatment that can be translated to the clinic. Using gene therapy, we have successfully translated several of our approaches to the clinic and continue to work hand-in-hand with clinicians at the hospital. Our laboratory is looking for a highly motivated, Research Associate with minimum 2 years of experience to join our young and energetic team. The position does not require a background in gene therapy, but experience in performance of ELISAs and ELISpots, or previous experience working in a clinical laboratory, would be of advantage. The candidate will perform research experiments using patient samples, document and maintain exact records of experiments, prepare laboratory reports and assist with analyzing data.


Link: https://careerspace.nationwidechildrens.org/ltm/CandidateSelfService/controller.servlet?context.dataarea=ltm&webappname=CandidateSelfService&HROrganization=10&JobReq=17792&JobPost=3&context.session.key.HROrganization=10&context.session.key.JobBoard=EXTERNAL&context.session.key.HROrganization=[Client%20Specific%20Code]&context.session.key.JobBoard=EXTERNAL&context.session.key.HROrganization=[Client%20Specific%20Code]&context.session.key.JobBoard=EXTERNAL#
Employer: Nationwide Children's Hospital
Location: Columbus, OH
Sector: Academia
Degree required: MS
Conditions: ALS
Job posted: February 16th, 2018
Nationwide Children's HospitalColumbus, OHMSALSFeb 16, 2018
NEW! Professor, Neurochemistry

Professor, Neurochemistry

(Click title to open job details in a new window.)
Description:

The professorship in neurochemistry will be placed at the Department of Biochemistry and Biophysiscs (DBB). Neurochemistry with molecular neurobiology is a predominant area of research and education at the department. Several research groups focus on molecular aspects of neurodegenerative mechanisms, studies of ion channels, neurotoxins, cellular differentiation, intra- and extracellular signal transduction and the blood-brain-barrier. A wide spectrum of analytical methods including biochemistry, bioinformatics, computational chemistry, biophysics and molecular biology are used and developed at the department. Other facilities at DBB include cell culture, MST, NMR, crystallography, cryo-electron microscopy, confocal microscopy and quantitative image analysis.


The environment for research and education within the subject neurochemistry with molecular neuorobiology at Stockholm University also includes scientists at the Department of Molecular Biosciences – The Wenner-Gren Institute and the Department of Zoology. Several research groups within the Department of Biochemistry and Biophysics are located at the Science for Life Laboratory. This is a national facility providing access to advanced methods for large-scale studies of nerve cell development, e.g. via single-cell sequencing and advanced imaging techniques. In addition the proximity to neuroscience departments at Karolinska Institutet, provides ample opportunities for fruitful collaborations. Furthermore, major investments have been and are being made at Stockholm University to create new infrastructures of relevance for neuroscience: a state-of-the-art animal facility with unique opportunities for integrated intravital microscopy, a cryo-EM microscope and the Stockholm University Brain Imaging Centre, an advanced interdisciplinary infrastructure for non-clinical research on brain function and structure.


Further information about the position can be obtained from the Head of the Department, Professor Lena Mäler, telephone: +46 8 16 24 48, lena.maler@dbb.su.se .


For questions regarding the application process, please contact administrator Katarina Gustafsson, telephone: +46 8 16 22 92, katarina.gustafsson@su.se.



Link: https://www.su.se/english/about/working-at-su/jobs?rmpage=job&rmjob=4552
Employer: Stockholm Universität
Location: Stockholm, Sweden
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: February 9th, 2018
Applications close: April 23rd, 2018
Stockholm Universität Stockholm, SwedenPhDNDGFeb 09, 2018
Director, Neuroscience Research

Director, Neuroscience Research

(Click title to open job details in a new window.)
Description:

The Florey Institute of Neuroscience and Mental Health is a world class research institute with its scientific outputs and esteem placing it in the top six neuroscience research centres in the world.


One in five peopleare affected by a brain disorder each year. The Florey has 600 dedicated staff and studentsbased in Melbourne who are passionately committed to researching the way the brain works in order to provideimproved medical treatments. Key areas of research include addiction, Alzheimer’s disease, cardiovascular disease, depression, epilepsy, Huntington’s disease, motor neuron disease, multiple sclerosis, Parkinson’s disease, schizophrenia, stroke and traumatic spinal cord injury.


The Florey extensively collaborates and works closely with the major universities, hospitals, governments and research facilities both nationally and internationally. Key strategic relationships locally include The University of Melbourne, Austin Health and Melbourne Health.


Interest is invited from the highest calibre senior research leaderswith the demonstrated capability to dynamically lead the Florey from its current strong position into its next era of scientific excellence, international pre-eminence and influence on the world stage. The key aspects of the role will include:


To develop and drive the Institute’s strategic direction to ensure the Florey becomes the world leader in neuroscience research;

Lead the wider neuroscience research community in Melbourne through the engagement and co-operation of research partners, inclusive of The University of Melbourne;

Commercial acumen to ensure a highly productive and financially sustainable future; and

Ambassadorial and advocacy influence.

The Director will also hold an appointment with The University of Melbourne as the Head of the Florey Department of Neuroscience and Mental Health in the Faculty of Medicine, Dentistry and Health Science.

Odgers Berndtson executive search is managing the process on behalf of the Selection Committee. All enquiries will be treated with strict confidence.


For further information, please contact the advising consultants: Dr Dennis Feeney, +61 2 8905 3722 or Caroline Dever, +61 429 939 399 or via email: florey@odgersberndtson.com.


Link: https://www.timeshighereducation.com/unijobs/en-us/listing/73481/director/
Employer: Florey Institute of Neuroscience and Mental Health
Location: Melbourne, Australia
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: February 8th, 2018
Applications close: March 5th, 2018
Florey Institute of Neuroscience and Mental HealthMelbourne, AustraliaPhDNDGFeb 08, 2018
Director, Neurodegenerative Disease Research, Cleveland Clinic

Director, Neurodegenerative Disease Research, Cleveland Clinic

(Click title to open job details in a new window.)
Description:

The Cleveland Clinic Department of Neurosciences and Neurological Institute are actively seeking a Director to head the Cleveland Clinic Neurodegenerative Disease Research Center. The Director will have the opportunity to lead, expand, and integrate basic, translational, and clinical research programs. Senior candidates with PhD and/or MD degrees and well-established, independently-funded research programs are encouraged to apply. The Department of Neurosciences, the Lerner Research Institute, and the Neurological Institute offer excellent research and core facilities, generous start-up funds, and ongoing operational support. Candidates should submit a curriculum vitae and a brief statement of research interests and vision for the Center via e-mail to nelsonc6@ccf.org.


Bruce D. Trapp, Ph.D.

Chairman, Department of Neurosciences

The Cleveland Clinic

9500 Euclid Avenue/NC30

Cleveland, OH 44195



Link: https://jobs.sciencecareers.org/job/475462/director-neurodegenerative-disease-research-cleveland-clinic/
Employer: Cleveland Clinic
Location: Cleveland, OH
Sector: Academia
Degree required: PhD and/or MD
Conditions: NDG
Job posted: February 6th, 2018
Cleveland ClinicCleveland, OHPhD and/or MDNDGFeb 06, 2018
Neurologist

Neurologist

(Click title to open job details in a new window.)
Description:

The Center for Alzheimer’s and Neurodegenerative Diseases at UT Southwestern Medical Center is accepting applications for a Board eligible/certified neurologist with an interest in cognitive and memory disorders. Research areas could include: 1) Running clinical trials; and 2) Studying clinical/pathological correlations of imaging and blood/CSF biomarkers. This faculty position will have a joint appointment in the Department of Neurology and Neurotherapeutics and the work will involve the interface of clinical and basic research.


The successful candidate will have fellowship training and a track record of publications appropriate to their level of experience. Current grant support, while desirable, is not a requirement. Appointment is anticipated to be a the Professor level, however, appointment rank will be commensurate with academic accomplishments and experience. Eligibility for a Texas Medical License is required.


Link: https://jobs.utsouthwestern.edu/job/neurologist-center-for-alzheimers-and-neurodegenerative-diseases-faculty-and-physicians-5323-harry-hines-blvd-da-26045/
Employer: UT Southwestern Medical Center
Location: Dallas, TX
Sector: Academia
Degree required: MD
Conditions: FTD
Job posted: February 3rd, 2018
UT Southwestern Medical CenterDallas, TXMDFTDFeb 03, 2018
Senior Technician, Project ALS Preclinical Core Facility

Senior Technician, Project ALS Preclinical Core Facility

(Click title to open job details in a new window.)
Description:

An exciting opportunity for a motivated Senior Technician to join our new Project ALS Preclinical Core Facility at Columbia University Medical Center. The facility tests new treatment strategies and research drugs in mouse models of amyotrophic lateral sclerosis.


Duties will include behavioral monitoring of mice, IP/IV/SC injections, tissue dissection and immunohistochemistry. The incumbent will also be responsible for confocal microscopy, image analysis, statistical evaluation of results, as well as preparing solutions and performing other laboratory related duties necessary to the functioning of the core facility and research projects.


Link: https://jobs.columbia.edu/applicants/jsp/shared/frameset/Frameset.jsp?time=1517848451093
Employer: Columbia University
Location: New York, NY
Sector: Academia
Degree required: BS
Conditions: ALS
Job posted: February 3rd, 2018
Columbia UniversityNew York, NYBSALSFeb 03, 2018
Assistant, Associate, Full Professor, Neurobiology

Assistant, Associate, Full Professor, Neurobiology

(Click title to open job details in a new window.)
Description:

The Department of Anatomy and Neurobiology (http://www.uthsc.edu/ anatomy-neurobiology/) at the University of Tennessee Health Science Center seeks an outstanding researcher in the area of mechanisms of neurodegenerative diseases to fill an open rank tenure track position (Assistant, Associate, Full Professor). We seek candidates to complement and extend departmental and campus-wide research in neurodegenerative diseases, especially, but not limited to, traumatic brain injury, chronic traumatic encephalopathy, stroke, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Research incorporating contemporary virally based circuit tracing, optogenetic and DREAD approaches are encouraged.


Successful candidates are expected to maintain an independent, extramurally funded research program, and contribute to the department’s teaching mission. The department and campus have state-of-the-art laboratories, core facilities, and unique populations of inbred mouse strains for elucidating the pathogenesis and treatment of neurodegenerative diseases (https://www.uthsc.edu/citg/mouse-strain-and-pilot-projects.php). We offer competitive salary and start-up packages, and membership in our vibrant interdepartmental Neuroscience Institute (http://www.uthsc.edu/neuroscience/).


Candidates must have a Ph.D. or M.D. and significant extramural funding. For best consideration applications should be submitted by April 1, 2018. Submit curriculum vitae, summary of research interests, and contact information for three references, in a single Word or PDF file to hsimmers@uthsc.edu.


Link: https://jobs.sciencecareers.org/job/475262/neuroscience-faculty-position/
Employer: University of Tennessee
Location: Memphis, TN
Sector: Academia
Degree required: PhD or MD
Conditions: ALS
Job posted: February 1st, 2018
Applications close: April 1st, 2018
University of TennesseeMemphis, TNPhD or MDALSFeb 01, 2018
Graduate Studentship, Charlet-Berguerand Lab

Graduate Studentship, Charlet-Berguerand Lab

(Click title to open job details in a new window.)
Description:

Recently, the most common genetic cause of ALS-FTD was identified as an expansion of CGGGGC repeats located within the first intron of the C9ORF72 gene. This mutation leads to expression of toxic dipeptide proteins translated from the GGGGCC repeats, and to decreased expression of the C9ORF72 gene. Currently, it is unclear which one of these mechanisms is the leading cause of motor neuron degeneration and death.


Our recent results (Sellier et al., 2016) indicate that C9ORF72 regulates macroautophagy, a catabolic process necessary to neurons. Furthermore, we identified various mutations of C9ORF72 in ALS patients. Our hypothesis is that these mutations may alter autophagy and consequently contribute to the neurodegenerescence observed in ALS-FTD. We are developing novel cell and mouse models that express these C9ORF72 mutations.


Thus, topic of this PhD project will be to characterize these novel models, notably alterations of autophagy and neuronal cell death. The candidate will investigate at the molecular and cellular level the effect of C9orf72 mutations on the autophagic clearence of protein aggregates (polyQ protein) and altered mitochondria (CCP treatment) using transformed and primary neuronal cell cultures and classic molecular and cellular approaches (RT-PCR, western, immunofluorescence, transfection and cell transduction, etc.). Furthermore, the candidate will study the phenotypes of mice expressing C9ORF72 mutations. This study will comprise animal behavior and motor performances using classic tests such as rotarod, grip test, catwalk, Y-maze, etc ; followed by molecular (RNA seq, qRT-PCR and western blotting)) and histological analyses (immunofluorescence, IHC).


REFERENCE : PHD NICOLAS CHARLET-BERGUERAND


Link: http://www.igbmc.fr/igbmc/recrutement/job_offer/470/print/
Employer: Institut de Génétique et Biologie Moléculaire et Cellulaire
Location: Illkirch-Graffenstaden, France
Sector: Academia
Degree required: BS
Conditions: ALS
Job posted: February 1st, 2018
Applications close: November 1st, 2018
Institut de Génétique et Biologie Moléculaire et CellulaireIllkirch-Graffenstaden, FranceBSALSFeb 01, 2018
Professor, Senior Lecturer, Multiple Positions

Professor, Senior Lecturer, Multiple Positions

(Click title to open job details in a new window.)
Description:

We have several outstanding opportunities for high quality neuroscientists to join the Sheffield Institute for Translational Neuroscience (SITraN) at the level of Senior Lecturer/Reader/Professor in Stem Cell Neurobiology; Neuropharmacology/Drug Discovery; Neurogenetics; or Neuroinflammation/Glial Biology.


We are seeking experienced scientists of the highest calibre capable of generating and sustaining a major programme of externally funded research within the fields of neurodegeneration, dementia and cerebrovascular disease. You will also play an important role in the wider translational agenda within the UoS Life Sciences for Health initiative to deliver effective translational science across faculties.


SITraN (www.SITraN.org) is an internationally leading centre for clinical translational research in Neurodegeneration and Cerebrovascular disease. Our core mission is to translate the opportunities of modern neuroscience into tangible benefi ts for patients. The scientific work of SITraN is directed into experimental studies through the associated NIHR Biomedical Research Centre for Translational Neuroscience based in Sheffield Teaching Hospitals NHS Foundation Trust. SITraN scientists contributed a major component of work into the 1st ranked UK Biomedical Sciences return to the 2014 Research Excellence Framework.


The posts will be will be supported by the excellent facilities at the University of Sheffield which is. One of the best not-for-profit organisations to work for in the UK. The University’s Total Reward Package includes a competitive salary, a generous Pension Scheme and annual leave entitlement, as well as access to a range of learning and development courses to support your personal and professional development. We build teams of people from different heritages and lifestyles whose talent and contributions complement each other to greatest effect.


Enquiries may be directed to Professor Dame Pamela Shaw at pamela.shaw@sheffield.ac.uk or Professor Chris McDermott at c.j.mcdermott@sheffield.ac.uk


Senior Lecturer/Reader/Professor of Stem Cell Neurobiology UOS018299

Senior Lecturer/Reader/Professor of Neuropharmacology/Drug Discovery UOS018300

Senior Lecturer/Reader/Professor of Neurogenetics UOS018301

Senior Lecturer/Reader/Professor of Neuroinflammation UOS018302


To apply, please click on the apply button to visit our website, then search for the role that fits you.


Closing date: 28 February 2018.


Link: https://www.nature.com/naturejobs/science/jobs/635473-senior-faculty-positions-in-neuroscience
Employer: University of Sheffield
Location: Sheffield, England
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: February 1st, 2018
Applications close: February 28th, 2018
University of SheffieldSheffield, EnglandPhDALSFeb 01, 2018
Postdoctoral Fellow, Ferraiuolo Lab

Postdoctoral Fellow, Ferraiuolo Lab

(Click title to open job details in a new window.)
Description:

Applications are invited for the post of Postdoctoral Research Associate within an internationally recognised research group in a vibrant and stimulating environment at the Sheffield Institute for Translational Neuroscience (SITraN).


We are seeking a highly motivated scientist to join an exciting new project at the translational medicine interface in Motor Neuron Disease (MND) research also known as Amyotrophic Lateral Sclerosis (ALS). You will be a practically skilled, well-organised and committed Postdoctoral Researcher who will join the team led by Dr Ferraiuolo.


Your project aims to investigate the role of exosomes secreted by mesenchymal stem cells in protecting motor neurons derived from MND patients co-cultured with MND astrocytes. You will be working in a semi-independent fashion, under the direction of the principal investigator, alongside a second year PhD student who will help you with experiments and data analysis. You will be expected to: design, execute and evaluate experiments; keep excellent experimental records; prepare reports regularly for the Motor Neurone Disease Association (MNDA), i.e. the funding body, and the collaborators on the project, Professor Dame Pamela Shaw in SITraN and Prof Bonanno at the University of Genoa. You are also expected to contribute to the preparation of scientific manuscripts, attend and deliver seminars and supervise the post-graduate student on the project.


You will have a strong background in molecular and cellular (neuro) biology with experience in a range of molecular and cellular biology techniques, particularly cell based assays in human reprogrammed cells. You should also hold a PhD in molecular or cellular biology, or neuroscience.


The candidate should be strongly motivated, self-driven, able to accept direction and be an excellent team player. Good communication, written and interpersonal skills are expected.


Contract Type: Fixed term for 12 months

Working Pattern: Full time

Faculty: Faculty of Medicine, Dentistry and Health

Department: Department of Neuroscience

Location: Sheffield Institute for Translational Neuroscience (SITraN)

Salary: Grade 7 – £30,688 – £38,833 per annum. Potential to progress to £42,418 per annum through sustained exceptional contributio


Link: https://jobs.shef.ac.uk/sap/bc/webdynpro/sap/hrrcf_a_posting_apply?PARAM=cG9zdF9pbnN0X2d1aWQ9MkQ5RkQ5OUM1NDI1MUVFODgxQjczQzEzNUFCRDhEMkYmY2FuZF90eXBlPUVYVA%3d%3d&sap-client=400&sap-language=EN&sap-accessibility=X&sap-ep-themeroot=%2fSAP%2fPUBLIC%2fBC%2fUR%2fuos#
Employer: University of Sheffield
Location: Sheffield, England
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: January 31st, 2018
Applications close: February 22nd, 2018
University of SheffieldSheffield, EnglandPhDALSJan 31, 2018
Postdoctoral Fellow, Wolozin Lab

Postdoctoral Fellow, Wolozin Lab

(Click title to open job details in a new window.)
Description:

A NIH funded postdoctoral position is available in the laboratory of Benjamin Wolozin to study the role of RNA binding proteins, RNA metabolism and RNA granules in the pathophysiology of neurodegenerative diseases. The postdoctoral fellow will investigate how these processes are regulated, and how dysfunction contributes to disease. The studies will use phase separation biology, cell biology, imaging, optogenetics, proteomics, systems biology and RNAseq. The studies will take advantage of our finding that reducing the RNA binding protein TIA1 delays progression in a mouse model of tauopathy (Apicco, et al, Nature Neuro., 21(1):72-80, PMID: 29273772.)


They will characterize the interactions between proteins and RNA, in the context of interaction networks of RNA granules and pathological complexes (e.g., tau, TDP-43, C9orf72). The goal will be to understand how the complexes change with disease, identify which are the crucial modulators of each type of complex, and identify methods of intervention to normalize the disease-related changes of these complexes.


Highest priority will be given to candidates who are about to finish their Ph.D., or within 1 year of finishing their Ph.D. (i.e., early postdocs). For more information, visit the Wolozin Lab website: http://www.bumc.bu.edu/busm-pm/faculty/faculty-profiles/wolozin/



Link: https://jobs.sciencecareers.org/job/475264/postdoctoral-fellow/?LinkSource=PremiumListing
Employer: Boston University
Location: Boston, MA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: January 31st, 2018
Boston UniversityBoston, MAPhDALSJan 31, 2018
Chair, Department of Translational Neurosciences

Chair, Department of Translational Neurosciences

(Click title to open job details in a new window.)
Description:

The University of Arizona College of Medicine – Phoenix is seeking an inaugural Chair for its new Department of Translational Neurosciences (TNS). TNS will be a novel medical school department, one that actively bridges basic science and clinical medicine through innovative collaborative research programs. The Chair will have the opportunity to create the overarching vision and, through strategic leadership, to build a center of translational neuroscience excellence. The Department Chair will have resources to recruit TNS faculty who will enhance our University of Arizona Health Sciences (UAHS) scientific community. We seek a visionary leader with expertise in molecular, cellular, or genetic approaches to neuroscience whose research is motivated by the challenges of nervous system disorders and directed toward advancing clinical care and improving human health in the foreseeable future.


Of particular interest for the Chair of TNS position are applicants with any of the following:


*Research portfolio focused on molecular, cellular, and/or genetic approaches to neuroscience. Examples of foci include: Neurodevelopmental disorders, Neuropsychiatric disorders, Disorders of the aging brain

*Expertise in use of cutting-edge technologies, including, but not exclusive to, patient-specific iPSC lines, CRISPR-Cas9, and in vivo brain imaging.

*Development and use of new animal models for disorders of the nervous system.

*Expertise in drug discovery or device development, including advancing to clinical trials.

*Knowledge of intellectual property issues in biomedical research (e.g., patent applications, working with industry partners).

*History of productive collaborations with both physicians and basic scientists.

For physician candidates, clinically active in specialty.


Link: https://uacareers.com/postings/26190
Employer: University of Arizona College of Medicine
Location: Phoenix, AZ
Sector: Academia
Degree required: PhD and/or MD
Conditions: NDG
Job posted: January 26th, 2018
University of Arizona College of MedicinePhoenix, AZPhD and/or MDNDGJan 26, 2018
Assistant or Associate Professor

Assistant or Associate Professor

(Click title to open job details in a new window.)
Description:

The Department of Cellular Biology and Anatomy, Medical College of Georgia, at Augusta University is undergoing an expansion of its research program and is seeking tenure-track faculty at the Assistant or Associate Professor levels. Academic rank will be commensurate with experience. The department is seeking candidates with an interest and expertise in diseases associated with aging. Preferential consideration will be given to investigators with research expertise related to Bone/Musculoskeletal, Renal, Visual or Neurodegenerative diseases, which will complement existing strengths within the department. Augusta University is the home of the only research-oriented, state-supported medical school in Georgia and offers an outstanding interdisciplinary environment. The research infrastructure includes state-of-the-art core facilities for confocal, multi-photon and super-resolution imaging, small animal behavior/imaging, proteomics, genomics including high throughput Illumina sequencing, flow cytometry, and electron microscopy/histology. Candidates at the Assistant Professor level must demonstrate a strong potential for research including obtaining extramural funding. Candidates at the Associate Professor level must possess external funding at the NIH R01 level and demonstrate potential for its continuation. The successful candidate will receive a nationally competitive start-up package, be expected to establish and maintain an extramurally funded research program, and participate in teaching. Applicants should submit a curriculum vitae, a statement of research objectives, a description of teaching interests/experience, and identify at least three individuals as references.


All applications will be confidential. Interested applicants should apply online at http://www.augusta.edu/jobs/faculty, Job Opening ID #13674.


Link: https://jobs.sciencecareers.org/job/474982/assistant-or-associate-professor-/
Employer: Medical College of Georgia
Location: Augusta, GA
Sector: Academia
Degree required:
Conditions: NDG
Job posted: January 24th, 2018
Medical College of GeorgiaAugusta, GANDGJan 24, 2018
Physician, Neuropathologist

Physician, Neuropathologist

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Description:

West Virginia University School of Medicine, Department of Pathology, Anatomy and Laboratory Medicine seeks an academically oriented, Board Certified/eligible Neuropathologist qualified for appointment at either the Assistant Professor, Associate Professor, or Professor rank with skills in surgical and autopsy neuropathology. Experience and ability to participate in other pathology specialty functions is desirable but not required. Pathologists with an academic focus in the neurosciences (eg, neurodegenerative disorders, tumor, stroke, etc) are encouraged to apply. Other service responsibilities and the effort levels designated in support of our academic and clinical service missions will be based on a candidate s training, skills and passions, as well as departmental and institutional needs. In addition to providing patient care, the successful candidate will be involved in the teaching of medical students and residents. For appointment at the Associate Professor or Professor rank, it is expected that candidates sustain an outstanding, extramurally supported research program.


Successful candidates must have an MD, MD/PhD or DO degree, be board certified/ eligible in AP or AP/CP and board certified/eligible in Neuropathology and be eligible to obtain an unrestricted West Virginia medical license. All qualifications must be met by the time of employment.


For additional questions, please contact Kelli Piccirillo, Senior Physician Recruiter, at piccirillok@wvumedicine.org.


Link: https://re12.ultipro.com/WES1019UHA/JobBoard/JobDetails.aspx?__ID=*C21B74D150BA7FE4
Employer: West Virginia University School of Medicine
Location: Morgantown, WV
Sector: Academia
Degree required: MD, MD/PhD or DO
Conditions: NDG
Job posted: January 22nd, 2018
West Virginia University School of MedicineMorgantown, WVMD, MD/PhD or DONDGJan 22, 2018
Postdoctoral Fellow, Sun Lab

Postdoctoral Fellow, Sun Lab

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Description:

Postdoctoral opportunities are available in Dr. Shuying Sun’s laboratory at Johns Hopkins University School of Medicine. The lab will explore the fascinating frontiers of RNA metabolism dysfunction and RNA-targeting therapy in neurodegenerative diseases by combining molecular and cellular approaches, genome editing, proteomic, genomic and screening platforms.


The nervous system has extremely complex RNA processing regulation and dysfunction of RNA metabolism has emerged to play crucial roles in multiple neurological diseases. Mutations and pathologies of several RNA-binding proteins are found to be associated with neurodegeneration in both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). An alternative RNA-mediated toxicity arises from microsatellite repeat instability in the human genome. The expanded repeat-containing RNAs could potentially induce neuron toxicity by disrupting protein and RNA homeostasis through various mechanisms.


The Sun lab is interested in deciphering the molecular mechanisms of disease pathogenesis and seeks to translate the mechanistic findings to therapeutic target development to advance treatment options against neurodegenerative diseases. We are looking for highly motivated postdoc fellows with solid PhD training in biochemistry, molecular and cellular biology. Experiences with RNA biology, neuroscience or bioinformatics are preferred but not limited to. You will join a strong and highly interactive science community at Johns Hopkins.


Interested candidates should provide a cover letter (with statement of research interest and career goals), CV and the contact information for three references to Dr. Shuying Sun at shuying.sun@jhmi.edu. Please visit our lab website at http://labs.pathology.jhu.edu/sun/ for additional information.


Link: http://neurojobs.sfn.org/jobs/10697767/postdoctoral-position-on-neurodegenerative-disease-and-rna-biology
Employer: Johns Hopkins University School of Medicine
Location: Baltimore, MD
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: January 20th, 2018
Johns Hopkins University School of MedicineBaltimore, MDPhDALS, FTDJan 20, 2018
Data Analyst

Data Analyst

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Description:

This analyst will work under the guidance of investigators in the Center for Biomedical Image Computing and Analytics (http://www.cbica.upenn.edu/, CBICA), Director, Christos Davatzikos, PhD.

The work involves applying, testing, validating and extending advanced image processing algorithms and protocols on multi-modal magnetic resonance brain images, collection, organization and verification of final quantitative results, performing data analysis, preparing and extending processing pipelines, and applying these pipelines on magnetic resonance brain imaging datasets from various studies involving both structural and functional data.


Strong computational skills (knowledge of Python, statistical analysis packages, basic shell scripting, experience in Unix platform) will be preferred. The data analyst will collect and organize final quantitative and imaging results, perform basic analyses including machine learning applications and perform quality control on the results, and communicate with clinical collaborators for the dissemination and discussion of the results. This position offers the opportunity to gain valuable experience using advanced neuroimaging processing techniques and to apply these methods in the study of normal and pathological brain function.


CBICA has been a dynamically growing medical image analysis group, including several laboratories and many collaborators from diverse fields. Opportunities exist in many existing and new projects, including computational neuroanatomy of aging and neurodegenerative diseases.


Link: https://main.hercjobs.org/jobs/10669149/data-analyst
Employer: University of Pennsylvania School of Medicine
Location: Philadelphia, PA
Sector: Academia
Degree required:
Conditions: NDG
Job posted: January 19th, 2018
University of Pennsylvania School of MedicinePhiladelphia, PANDGJan 19, 2018
Assistant Professor, Neuroscience

Assistant Professor, Neuroscience

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Description:

The George & Anne Ryan Institute for Neuroscience at the University of Rhode Island invites applications for Ryan Assistant Research Professor of Neuroscience, beginning Fall 2018.


The Ryan Institute for Neuroscience is a multidisciplinary research and translational science center with more than 30 affiliated faculty. The institute brings together top researchers and clinicians in the fight against neurodegenerative diseases, with a focus on discoveries that lead to therapies.


The successful candidate will join a team studying the cell and molecular biology and biochemistry of brain endothelial cells as it relates to neurodegenerative disease, especially Alzheimer’s disease. They will also provide scientific leadership and mentoring of postdoctoral fellows, graduate students, and staff engaged in other projects, and will contribute to setting the strategy and research plans for the group. This position reports to the Executive Director of the Ryan Institute for Neuroscience.


Visit the URI jobs website at: https://jobs.uri.edu to apply and view complete details for job posting (F00072). Please attach the following 3 (PDF) documents to your online Faculty Employment Application: (#1) Cover letter including a description of how your qualifications match the requirements for the position, (#2) Curriculum Vitae should include the names and contact information of three professional references, (#3) Research Statement or sample(s) of relevant scholarly work (as one complete document).


APPLICATION DEADLINE: This search is open until filled. First consideration will be given to applications received by February 25, 2018. Second consideration may be given to applications received by April 15, 2018. Applications received subsequent to second consideration date (April 15, 2018) may not be given full consideration.


APPLICATIONS MUST BE SUBMITTED ONLINE ONLY.


Link: http://neurojobs.sfn.org/jobs/10666042/assistant-research-professor-of-neuroscience
Employer: University of Rhode Island
Location: Kingston, RI
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: January 18th, 2018
Applications close: February 25th, 2018
University of Rhode IslandKingston, RIPhDNDGJan 18, 2018
Head of Translational Science

Head of Translational Science

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Description:

The University of Texas Southwestern Medical Center, Center for Alzheimer’s and Neurodegenerative Diseases (CAND), is seeking applications for a faculty position as Head of Translational Science. Responsibilities include supporting the translation of novel targets and inventions into viable drug development and/or patient care solutions, engaging with Principal Investigators (PI’s), postdocs, and students to advance inventions from CAND laboratories, advancing high-throughput screening (HTS) hits into lead series, optimizing lead series to IND-ready clinical candidates, connecting entrepreneurs, bankers, and venture funds with CAND science, and utilizing Contract Research Organization (CRO) network to rapidly and cost-effectively advance CAND programs. Appointment rank will be commensurate with academic accomplishments and experience.Candidates must have a Ph.D. in chemistry, life sciences or a related discipline, practical experience in advancing drug programs into the clinic and validation of novel targets with in vivo proof of concept experiments.Desired skills include medicinal chemistry and DMPK expertise, hit and lead series evaluation, competitive analysis of programs, intellectual property path advisement, ability to connect CAND PI’s with resources such as CRO’s for chemistry and pharmacology, on-campus capabilities and UT System resources, grant writing, and design and interpretation of clinically relevant PI/PD experiments.


Link: https://neuvoo.com/view/?id=znjdnky2zy
Employer: University of Texas Southwestern Medical School
Location: Dallas, TX
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: January 18th, 2018
University of Texas Southwestern Medical SchoolDallas, TXPhDNDGJan 18, 2018
Assistant Project Scientist

Assistant Project Scientist

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Description:

Main focus: Identification of regulators of neurodegeneration using systems biology approaches.

Mutations causing the most common form of early onset dementia, frontotemporal dementia, have been identified, but the subsequent disease mechanisms are not well understood. Recent advances in genetics have pinpointed genes causing risk for dementia in specific cell-types. This project attempts to gain important advances in understanding the basic mechanisms in neurodegeneration and find regulators of neurodegeneration. The project will employ systems biology approaches to integrate genomics, transcriptomics, proteomics and molecular biology to unravel multi-dimensional data and to find robust targets which can then be validated in in vitro and in vivo model systems of neurodegeneration

To address these challenges, several projects are required the Project Scientist oversee 1) to define distinct cell population in diseased human brain using single-nuclear transcriptomics, and develop bioinformatics approaches to find disease specific cell types; 2) to identify drivers of neurodegeneration using systems biology approaches by integrating high-dimensional data from human and mouse models; This requires implementation of CRISPR-Cas9 genomic engineering approaches to target hub or regulatory genes implicated in neurodegeneration. and 3) to study and characterize miR-203 knock-in overexpression mice. Main focus: Identification of regulators of neurodegeneration using systems biology approaches.

Mutations causing the most common form of early onset dementia, frontotemporal dementia, have been identified, but the subsequent disease mechanisms are not well understood. Recent advances in genetics have pinpointed genes causing risk for dementia in specific cell-types. This project attempts to gain important advances in understanding the basic mechanisms in neurodegeneration and find regulators of neurodegeneration. The project will employ systems biology approaches to integrate genomics, transcriptomics, proteomics and molecular biology to unravel multi-dimensional data and to find robust targets which can then be validated in in vitro and in vivo model systems of neurodegeneration

To address these challenges, several projects are required the Project Scientist oversee 1) to define distinct cell population in diseased human brain using single-nuclear transcriptomics, and develop bioinformatics approaches to find disease specific cell types; 2) to identify drivers of neurodegeneration using systems biology approaches by integrating high-dimensional data from human and mouse models; This requires implementation of CRISPR-Cas9 genomic engineering approaches to target hub or regulatory genes implicated in neurodegeneration. and 3) to study and characterize miR-203 knock-in overexpression mice.


Link: https://recruit.apo.ucla.edu/apply/JPF03512
Employer: UCLA
Location: Los Angeles, CA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: January 16th, 2018
Applications close: February 19th, 2018
UCLALos Angeles, CAPhDNDGJan 16, 2018
Clinical Cognitive Neuroscientist

Clinical Cognitive Neuroscientist

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Description:

Cognitive Neuroscience at the University of Nebraska Medical Center. The Department of Neurological Sciences at the University of Nebraska Medical Center invites applications for a tenure leading faculty position in Clinical Cognitive Neuroscience. This position is part of a new Neuroimaging Section within the department and aims to leverage multiple hires across the School of Medicine in human neuroscience. We welcome applications from any area of cognitive neuroscience, including memory, executive function, visual attention, perception, audition, motor control, emotion, and decision-making. Methodological specialty within neuroimaging is open, but ideally the candidate would benefit from our strong existing program in MEG imaging, and develop a translational, theory-based multimodal neuroimaging program focusing on their area of interest. The successful applicant would join a growing group of cognitive neuroscientists within the department (and across campus) using MEG, fMRI, and other modalities, and hopefully help grow other programs in parallel with building their own.


Successful candidates will have a MD, PhD, or MD/PhD in neuroscience, psychology, or computer science, with postdoctoral training and an excellent publication record for their career stage. Candidates should also have an excellent and sustained record of research and evidence of the potential, or demonstrated ability, to generate extramural funding commensurate with their career stage. Applicants should have the ability and interest to teach graduate courses in cognitive neuroscience, and to mentor PhD students in our growing Neuroscience PhD program.


The University of Nebraska Medical Center (UNMC) is a vibrant multidisciplinary research environment with major resources and ample opportunities for training and collaboration. Resources include a 306-sensor MEG system, multiple 3T human MRI scanners, high-definition transcranial direct-current and alternating-current stimulation (HD-tDCS/tACS) equipment, eye-tracking equipment, and a state-of-the-art transcranial magnetic stimulation (TMS) suite. The UNMC is located in Omaha, with a metro area population of approximately one million, and major attractions and events such as the College World Series.


Please submit a letter detailing current research and teaching interests, a curriculum vitae, a list of the applicant’s five most important publications, and contact information for three individuals who will provide letters of recommendation at a later time. Applications should be submitted online at: http://unmc.peopleadmin.com/postings/36674. Review of applications will begin immediately and will continue until the position is filled. Start dates are negotiable, but ideally before the close of 2018. Individuals from diverse backgrounds are encouraged to apply.


Required Qualifications:


A record of excellence in independent investigative work.

Ability to establish and maintain a robust externally funded clinical cognitive research program bridging basic and applied neurology.

MD, MD/PhD, or PhD

APBN Board eligible or certified (if MD)

Committed to Research Clinical Care, Education and Outreach.


Link: http://unmc.peopleadmin.com/postings/36674
Employer: University of Nebraska Medical Center
Location: Omaha, NE
Sector: Academia
Degree required: MD, MD/PhD, or PhD
Conditions: NDG
Job posted: January 14th, 2018
University of Nebraska Medical CenterOmaha, NEMD, MD/PhD, or PhDNDGJan 14, 2018
Postdoctoral Fellow or Senior Research Scientist, Gao Lab

Postdoctoral Fellow or Senior Research Scientist, Gao Lab

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Description:

A position at the postdoctoral or Senior Research Scientist level is immediately available in the laboratory of Dr. Fen-Biao Gao at the University of Massachusetts Medical School to study molecular pathogenic mechanisms of fronototemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) (Lu et al., Mol. Cell 2013; Gascon et al., Nat. Med. 2014; Freibaum*, Lu* et al., Nature 2015; Tran et al., Neuron 2015; Lopez-Gonzalez et al., Neuron 2016). Candidates with strong research experience in mouse genetics and molecular and cellular biology are encouraged to apply. Interested please send CV to fen-biao.gao@umassmed.edu


Link: https://www.nature.com/naturejobs/science/jobs/634157-postdoctoral-fellow-or-senior-research-scientist-level
Employer: University of Massachusetts Medical School
Location: Worcester, MA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: January 12th, 2018
Applications close: March 13th, 2018
University of Massachusetts Medical SchoolWorcester, MAPhDALSJan 12, 2018
Graduate Studentship

Graduate Studentship

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Description:

We are looking for highly motivated candidates to explore the role of C9ORF72 in neurodegeneration associated with amyotrophic lateral sclerosis (ALS). ALS is a motor neuron disease characterised by progressive injury and death motor neurons in the brain and spinal cord. Recent reports suggest that C9ORF72 hexanucleotide intronic repeat expansion cause ALS with high prevalence in both familial and sporadic cases. The C9ORF72 gene is located on chromosome 9p (9p21) and encodes twelve exons, with three transcription variants, and two possible protein isoforms, termed a and b. The normal expansion typically comprises a fewer than 30 of GGGGCC repeats. Pathogenic expansions consists of hundreds to thousands repeats. RNA foci are observed in fibroblasts and CNS of patients with C9ORF72 expansion, suggesting defects of RNA metabolism. Despite the significant progress in C9orf72 research, the exact function of the C9orf72 protein remains unclear. Thus, further research efforts aimed at better understanding the role of C9ORF72 protein are of the utmost importance to enable therapeutic development for ALS.


The successful candidate will join a team of several postdocs and technicians and he/she will benefit from their support and expertise. The student will use/learn cell culture, basic molecular biology techniques, CRISPR/Cas9 approach, iPS -derived from ALS patients, viral vector design/production and in vivo work. Gene manipulation in the cell culture model will be made using viral vectors and CRISPR Cas9 to modulate C9ORF72 gene. The student will attend several courses/workshops including Home Office course for in vivo experimentation. We support our PhD students to attend and present their research findings at national and international conferences.


The proposed work will be undertaken within the Sheffield Institute for Translational Neuroscience (SITraN: http://www.sitran.org/people), a world class environment for translational research. SITraN was specifically designed to bring together a multidisciplinary team of scientists, bioinformaticians and clinicians in order to effectively translate basic science discoveries into potential neuroprotective therapies for patients with MNDs. SITraN hosts state-of-the-art laboratories and equipment with a collaborative, multi-disciplinary environment including expertise in basic neuroscience, gene therapy, clinical neurology, neuropathology, computational biology, high throughput genomics and clinical trials methodology. The dedicated research accommodation encompasses tissue culture and gene therapy suites, facilities for live cellular imaging, confocal microscopy, laser capture microdissection, next generation sequencing, gene expression arrays and small molecule drug screening. We have an inter-faculty computational biology team embedded within SITraN that integrates and analyses our high dimensional data to iteratively develop systems models of disease.


The assembled team of supervisors has significant track record in studying the biochemistry of neurological disorders, vector design and evaluation in pre-clinical studies using in vivo models of neurodegeneration. This is reflected in high impact publications in prestigious journals such as Nature, Nature Medicine and Science Translational Medicine, PNAS. For further info about the project please contact Prof Mimoun Azzouz (m.azzouz@sheffield.ac.uk) and Dr Guillaume Hautbergue (g.hautbergue@sheffield.ac.uk).


Interested candidates should in the first instance contact:

Prof Mimoun Azzouz (m.azzouz@sheffield.ac.uk) and Dr Guillaume Hautbergue (g.hautbergue@sheffield.ac.uk).


To apply, please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply Please clearly state the prospective main supervisor in the respective box and select neuroscience as the department.


Link: http://www.shef.ac.uk/postgraduate/research/apply
Employer: University of Sheffield
Location: Sheffield, England
Sector: Academia
Degree required: BS
Conditions: ALS
Job posted: January 8th, 2018
University of SheffieldSheffield, EnglandBSALSJan 08, 2018
Postdoctoral Fellow, Plowman Lab

Postdoctoral Fellow, Plowman Lab

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Description:

The Department of Speech, Language, and Hearing Sciences at the University of Florida has a funded post-doctoral associate position available to work in the Swallowing Systems Core under the direct mentorship of Dr. Emily Plowman. This line is funded by an R01 grant from the National Institute of Neurological Disorders and Stroke (N.I.N.D.S) in the area of bulbar dysfunction in individuals with Amyotrophic Lateral Sclerosis. The successful post-doctoral associate would have the opportunity to work in the Swallowing Systems Core (SSC) that combines the expertise of both Dr. Plowman and Dr. Ianessa Humbert. The Swallowing Systems Core (SSC) is housed within the Dental Tower of Shands Hospital in the University of Florida Health Science Center and is equipped with its own research dedicated C-arm to perform high-resolution videofluoroscopy, fiberoptic endoscopic evaluation of swallowing workstation and high resolution manometry set up. The SSC currently comprises two Co-directors (Plowman and Humbert), two full time clinical coordinators, a biomedical engineer, four doctoral students, seven masters’ thesis students and five undergraduate honors students. The successful applicant would be expected to work cohesively with the entire SSC team.


Further, the post-doc associate will work collaboratively with the SSC research team to collect and analyze data, build grant-writing skills, prepare manuscripts for publication, and participate at national and international scientific meetings. As one of the country’s leading research institutions, the University of Florida provides an exceptionally supportive environment for research and collaboration. University support includes integrated and state of the art computer technology, exceptional students and staff, and a network of world-renowned scientists.


Interested applicants should submit: (1) a cover letter, (2) curriculum vitae, (3) a 1-page personal statement including research goals and how prior training and interests prepare you for this position, and (4) at least three letters of reference with their online application. Materials may be addressed to Emily K. Plowman, Ph.D. Review of applications will begin immediately. The successful applicant could begin in February of 2018.


SALARY: $47,476 USD, commensurate with education, skills, and experience


Link: http://explore.jobs.ufl.edu/cw/en-us/job/505893/postdoctoral-associate
Employer: University of Florida
Location: Gainesville, FL
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: January 5th, 2018
University of FloridaGainesville, FLPhDALSJan 05, 2018
Research Assistant, Jackrel Lab

Research Assistant, Jackrel Lab

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Description:

The Jackrel Lab is interested in hiring a research specialist. We are looking for recent graduates in Chemistry, Biochemistry, Biophysics, Cell Biology, Genetics, Neuroscience, and related areas. Applicants with more senior experience will also be considered. Responsibilities will include driving an independent research project and assisting in the general organization and running of the lab. We study protein folding and misfolding, and how protein misfolding can lead to neurodegenerative disease. For more information about our research interests, please visit: https://sites.wustl.edu/jackrel/


Link: https://main.hercjobs.org/jobs/10625703/research-lab-assistant-chemistry-38920
Employer: Washington University
Location: Saint Louis, MO
Sector: Academia
Degree required: BS
Conditions: NDG
Job posted: January 5th, 2018
Washington UniversitySaint Louis, MOBSNDGJan 05, 2018
Scientific Director, Research Professor

Scientific Director, Research Professor

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Description:

VIB and UAntwerp are in search for a dynamic, internationally recognized leader in genetics and genomics to inspire and lead the VIB research centre at the University of Antwerp. The selected candidate will be appointed as scientific director at VIB and will have a research professor appointment (ZAPBOF) as (full) professor at the University of Antwerp.


The scientific director/research professor will provide vision and leadership to the research centre, with responsibility for: developing the scientific strategy of the research centre and its future mission

creating a stimulating environment and dialectic culture, which fosters talent and triggers excellence

organizing and managing the research centre in terms of science, tech transfer, logistics, finance and human talent. It is expected that the scientific director/research professor will maintain active interest in leading an independent research lab (for which significant long term support will be provided). The scientific director/research professor will be a member of the VIB management committee in which he/she has co-responsibility for the overall success of VIB.


Candidates who are interested in this position are asked to send a complete CV, publication list, vision text (max. 5000 words) and 3 letters of reference to marijke.lein@vib.be and vacatures@uantwerpen.be. Closing date for applications is 31 March 2018.


Link: https://vibvzw.jobsoid.com/j/11077/scientific-director-research-professor
Employer: VIB and University of Antwerp
Location: Antwerp, Belgium
Sector: Academia
Degree required: PhD
Conditions: FTD, NDG
Job posted: January 2nd, 2018
VIB and University of AntwerpAntwerp, BelgiumPhDFTD, NDGJan 02, 2018
Assistant Professor, Pharmacology and Chemical Biology

Assistant Professor, Pharmacology and Chemical Biology

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Description:

The Department of Pharmacology at the Emory University School of Medicine invites applications for tenure-eligible Assistant Professor positions. Applicants for other ranks will also be considered. Beginning immediately, we seek investigators who will develop independent and vigorous research programs in any area of pharmacology and chemical biology. Individuals with demonstrated research interests and accomplishments in chemical biology, molecular pharmacology, systems pharmacology, as well as innovative approaches for therapeutic discovery and disease biology are encouraged to apply.


The successful candidates will join a vibrant and collegial basic research department with extensive scientific connectivity with clinical departments and divisions across the campus, including the Winship Cancer Institute, Dept of Chemistry, Dept of Pediatrics, Dept of Medicine, Dept of Hematology and Medical Oncology, Dept of Neurology, Center for Neurodegenerative Diseases, and other research units of the School of Medicine.  New faculty will have immediate access to powerful research infrastructures and core facilities, including the well-recognized Emory Chemical Biology Discovery Center with state-of-the-art high-throughput screening capabilities as well as a top-ranked graduate training program in pharmacology. The Department of Pharmacology at Emory is experiencing another phase of growth with the strong commitment of the leadership of the Woodruff Health Science Center and the School of Medicine, who share a focused vision for therapeutic innovation and translational biology.


Candidates must have a Ph.D., M.D., or equivalent degree in a relevant field of study, postdoctoral experience, and a demonstrated record of research excellence. Applicants should submit (i) a cover letter, (ii) a curriculum vitae, (iii) a brief statement of past research accomplishments, future research interests and goals, and teaching interest (<3 pages), and (iv) names and contact information for three references, in one pdf file to the Emory Pharmacology Search Committee, c/o Tanisha Haynes (tdevorc@emory.edu). Applicants should also arrange for three letters of reference to be sent directly to the above e-mail address. Consideration of applications for interviews will begin by January 30, 2018.


Link: https://jobs.sciencecareers.org/job/474128/assistant-professor-positions-in-pharmacology-and-chemical-biology/?LinkSource=PremiumListing
Employer: Emory University School of Medicine
Location: Atlanta, GA
Sector: Academia
Degree required: PhD and/or MD
Conditions: NDG
Job posted: December 29th, 2017
Emory University School of MedicineAtlanta, GAPhD and/or MDNDGDec 29, 2017

Industry

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Medical Director

Medical Director

(Click title to open job details in a new window.)
Description:

Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to the genetics and biology of neurodegeneration and the principles of translational medicine. In anticipation of the Company’s growth plans, Denali Therapeutics is seeking to recruit a Medical Director. The Medical Director will be responsible for design, implementation, monitoring, analysis, and reporting of clinical trials and will provide strategic leadership for development programs.



Link: https://www.denalitherapeutics.com/careers/?gh_jid=954871
Employer: Denali Therapeutics
Location: San Francisco, CA
Sector: Industry
Degree required: MD or MD/PhD, Neurology
Conditions: NDG
Job posted: February 15th, 2018
Denali TherapeuticsSan Francisco, CAMD or MD/PhD, NeurologyNDGFeb 15, 2018
NEW! Research Scientist

Research Scientist

(Click title to open job details in a new window.)
Description:

This scientist will lead an early-stage, hit-to-lead drug development project for Amyotrophic Lateral Sclerosis (ALS). Initially, he or she will conduct in-house experiments and work with external collaborators and CROs to establish a structure-activity relationship and guide the associated medicinal chemistry work. This individual will advance the project into the lead optimization phase, including ADME and in vivo efficacy. The requirements include a PhD in the biomedical sciences, competency in mammalian cell culture and assay development, background in neuroscience research, and industry experience in CNS drug development. Salary will be commensurate with experience; BrainXell offers full health and dental benefits.


Link: https://www.indeed.com/jobs?q=brainxell&l&vjk=df50b84b4e342109
Employer: BrainXell
Location: Madison, WI
Sector: Industry
Degree required: PhD
Conditions: ALS
Job posted: February 15th, 2018
BrainXellMadison, WIPhDALSFeb 15, 2018
NEW! Research Scientist, Senior Research Scientist, Biomarkers

Research Scientist, Senior Research Scientist, Biomarkers

(Click title to open job details in a new window.)
Description:

Denali Therapeutics is seeking to recruit a Research Scientist/Senior Research Scientist in support of the company’s growing translational biology and biomarker needs. This individual will work in close collaboration with colleagues in the In Vivo group, Research, Development Sciences, and Clinical Development to implement biomarker assays in support of preclinical target engagement studies. S/He would also contribute towards discovery/development of novel biomarkers for target engagement assessment and disease biology.


Link: https://www.denalitherapeutics.com/careers/?gh_jid=973466
Employer: Denali Therapeutics
Location: San Francisco, CA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: February 15th, 2018
Denali TherapeuticsSan Francisco, CAPhDNDGFeb 15, 2018
Research Associate, Neuro-Muscular Group

Research Associate, Neuro-Muscular Group

(Click title to open job details in a new window.)
Description:

We are seeking a Research Associate to join the Neuro-Muscular group at CRISPR Therapeutics, an exciting, fast growing and well-financed company. The successful candidate will be an integral part of a team whose aim is to discover the next generation of genetic therapies for serious neurodegenerative diseases. The position requires enthusiasm, passion, attention to detail and a desire to create new medicines for patients.


Responsibilities


*Perform research with the aims of developing next-generation gene editing strategies using CRISPR-based gene editing tools for neurodegenerative disorders

*Perform research requiring molecular biology techniques including cloning, qPCR, NGS, RNA and DNA analysis, ddPCR and other plate-based assays

*Perform research requiring cell biology techniques including primary cell culture, transfection, FACS, and cell-based assays

*Analysis and presentation of experimental data


Link: http://www.crisprtx.com/careers/careers-ra-neuro-muscular-group-molecular-and-cell-biology.php
Employer: CRISPR Therapeutics
Location: Cambridge, MA
Sector: Industry
Degree required: BS
Conditions: NDG
Job posted: February 5th, 2018
CRISPR TherapeuticsCambridge, MABSNDGFeb 05, 2018
Senior Scientist, Process Development

Senior Scientist, Process Development

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Description:

Voyager is seeking two highly motivated Senior Scientists to join the Process Development Group with a focus on (1) upstream; and (2) downstream purification.


The qualified candidate will be a leader within the group with a strong background and expertise in downstream manufacturing of biologics. Primary responsibilities will include carrying out downstream process development activities for the manufacture of pre-clinical and cGMP grade rAAV products, participating in and leading internal productions, writing appropriate documents and carrying out technology transfer to assorted CMOs, and finally participating in cGMP manufacture person in plant activities. The ability to independently organize and design experiments, analyze data and report the results of their and other’s work in a concise and well documented manner, and to take the initiative to successfully drive Voyager’s projects and manufacturing process are all important aspects of the position.


Link: http://www.voyagertherapeutics.com/join-our-team/careers/
Employer: Voyager Therapeutics
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: ALS
Job posted: February 1st, 2018
Voyager TherapeuticsCambridge, MAPhDALSFeb 01, 2018
Senior Scientist

Senior Scientist

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Description:

AveXis is seeking an experienced Sr. Lab Scientist to join the dynamic and growing analytical team to help establish analytical methods for process characterization and lot release of the clinical or commercial materials. The individual will collaborate closely with the internal R&D team to develop and optimize meaningful, next-generation cell-based potency and other functional assays in support of development and commercialization of new gene therapy medicines. The individual will be responsible for assay optimization and troubleshooting as well as for ensuring consistency of assay performance and cell culture work. The individual will play an important role in method qualification/validation and method transfer to internal and/or external QC laboratories. Responsibilities will also include execution of routine assays and supporting lab operation. Successful candidate will have extensive experiences in tissue culture work and will be a fast-learner with passion for innovative technology and science.


Link: https://careers-avexis.icims.com/jobs/1093/sr.-lab-scientist/job
Employer: AveXis
Location: San Diego, CA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: January 16th, 2018
AveXisSan Diego, CAPhDNDGJan 16, 2018
Principal Scientist, Neuroscience, In Vivo Pharmacology

Principal Scientist, Neuroscience, In Vivo Pharmacology

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Description:

The successful candidate will be a member of the West Point Pharmacology Department, a department that provides in vitro and in vivo pharmacology solutions to support a wide variety of neuroscience, infectious disease, and cardio-metabolic programs.


The successful candidate will have had experience in designing and executing in vivo behavioral and physiological experiments to determine the efficacy of novel compounds designed to have efficacy across a range of neuroscience indications including neurodegeneration, psychiatry, and pain. In addition, the candidate should have extensive experience in developing novel models in support of neuroscience programs; have experience in PK/PD modeling and a solid grounding in drug discovery research in the Biotech or Pharmaceutical industry. The individual would be expected to act as an independent scientist in leading the in vivo pharmacological needs of multiple projects in a wide array of neuroscience indications, and have shown ability to lead in the field.


Key responsibilities:

*Performing all aspects of running in vivo models supporting neuroscience indications to drive forward the goals of the Pharmacology and Neuroscience departments.

*Core and project team member of multiple projects across neuroscience discovery programs. Demonstrate a high degree of influence and leadership in these projects through past experiences at this level.

*Provide mentorship and supervisory role to researchers at scientist level within the team.

*Deliver scientific, regulatory and project management leadership within and across departments and line functions.

*Interface with other departments including disease area biologists, safety assessment, chemistry, and pharmacokinetics & drug metabolism

*Work with groups external to Merck e.g. contract resource organizations to access novel assays and/or manage workload effectively.


Qualifications:


Education: A Ph.D. in Neuroscience or pharmacology (with neuroscience background)


Required:

*A minimum of 8 years of experience post PhD with at least 5 years in the biotechnology or pharmaceutical industries.

*Proven ability to drive projects forward

*Extensive knowledge and hands on experience of translational neuroscience animal models

*Track record of performance on drug discovery teams

*Experience developing practical research strategies, translating strategy into experiments

*Experience managing and mentoring direct reports

*Ability to work in a matrixed organization


Preferred:

*Hands on experience with cognitive / behavioral experiments with in vivo and/or primates.

*Hands on experience with In vivo physiological and/or electrophysiological experiments in in vivo and/or primates.

*Hands on experience with in vivo neurodegenerative experiments in rodents and/or primates


Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life.


If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to staffingaadar@merck.com.


Link: https://jobs.sciencecareers.org/job/474476/principal-scientist-in-vivo-pharmacology-neuroscience/
Employer: Merck
Location: West Point, PA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: January 11th, 2018
MerckWest Point, PAPhDNDGJan 11, 2018
Associate Scientist

Associate Scientist

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Description:

Amgen is seeking an Associate Scientist to join the Neuroscience Department at our research facility in Cambridge, MA. The Associate Scientist will work independently and as part of cross-disciplinary teams. The Associate Scientist will join an energetic research team responsible for the design and execution of innovative assays and the production of high quality data with the goal of developing therapeutics for neurological disorders with an emphasis on Neurodegenerative Diseases (Parkinson’s disease, Alzheimer’s disease, and Amyotrophic Lateral Sclerosis).


Responsibilities:

Growing and assessing primary neuronal cells and stem cell-derived neurons.

Differentiating and characterizing induced pluripotent stem cell (IPSC)-derived neurons. Additional responsibilities include assay development, conducting high content imaging, using multi-electrode array technology, testing small molecules and biologics, as well as analyzing and communicating results to the research team and department.


Basic Qualifications: Master’s degree and 2 years of scientific experience OR Bachelor’s degree and 4 years of scientific experience


Preferred Qualifications

*A demonstrated strong background in Neuroscience

*Knowledge of IPSC-derived dopamine neurons

*Ability to design and execute experiments independently

*Excellent communication skills and the desire to work in a team

*In vitro cell culture of primary neurons, stem cells, and various neuronal tissues

*Strong background in cellular neuroscience techniques; experience with electrophysiology

*Computer literacy, analytical and problem-solving skills, highly organized and ability to multi-task


Link: https://careers.amgen.com/job/7959560/associate-scientist-cambridge-ma/
Employer: Amgen
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: ALS
Job posted: January 10th, 2018
AmgenCambridge, MABS or MSALSJan 10, 2018
Research Associate, Process Analytics

Research Associate, Process Analytics

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Description:

Voyager Therapeutics is a gene therapy company developing life-changing treatments for severe neurological diseases. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector optimization and engineering, dosing techniques, as well as process development and production. The company’s pipeline is focused on severe neurological diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease, spinal muscular atrophy (SMA), frontotemporal dementia and Alzheimer’s disease and severe chronic pain.


Voyager is seeking a highly motivated Research Associate for a position within the analytical development group. The qualified candidate will maintain adherent cell culture and plate cells for bioassays using aseptic conditions. The candidate will also perform analysis of process development and pre-clinical grade materials. After product testing, the candidate will be responsible for data analysis as well as reporting of data. Responsibilities include, but not limited to the following. This position in located in Cambridge, MA.


· Maintain cell culture and plate cells for bioassays under aseptic conditions


· Independently, conduct assays on in-process and final products


· Perform routine assays on a weekly basis to determine product quality


· Analyze data and record results into ELN/LIMS in a timely manner


· Formulation and testing of buffers and materials needed for routine assays


· Perform both qualitative and quantitative analysis of proteins (ELISA, Western blot, silver stain/PAGE) and DNA (qPCR, agarose gel electrophoresis)


Qualifications


· BS in Biochemistry/Biology/Chemistry/Virology or a related field


· 1-3 years of relevant experience in (Biotech/Biopharma) industry


· Experience testing AAV or similar gene therapy viral vectors highly preferred


· Experience with aseptic adherent mammalian cell culture maintenance is important for qualifying for this position


· Strong desire to learn multiple techniques and willingness to provide support as required


· Significant attention to detail and accuracy in following protocols


· Demonstrated ability to be highly productive in a fluid, fast-paced and team work environment


Link: https://www.linkedin.com/jobs/view/563408945/
Employer: Voyager Therapeutics
Location: Cambridge, MA
Sector: Industry
Degree required: BS
Conditions: ALS
Job posted: January 8th, 2018
Voyager TherapeuticsCambridge, MABSALSJan 08, 2018

Non-Profit and Government

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
Associate Scientist

Associate Scientist

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Description:

The ALS Therapy Development Institute (ALS TDI) has an opening for a full-time Associate Scientist working in the Translational Research group. The Associate Scientist will be part of the team working to develop patient-derived induced pluripotent stem cell (iPSc) collection, as well as the development and implementation of cell-based high content screens for target and drug discovery.


Responsibilities include but are not limited to:


*Isolation and banking of patient-derived primary cells

*Generating and characterizing of iPSc and their differentiated derivatives

*Assisting in the development and characterization of isogenic genome-edited and patient-derived cell-based screening models


Link: https://www.indeed.com/viewjob?jk=6b88fbc755066cdf&q=amyotrophic&tk=1c3bcvhu05ut4fbr&from=web
Employer: ALS Therapy Development Institute
Location: Cambridge, MA
Sector: Non-Profit
Degree required: BA or BS
Conditions: ALS
Job posted: January 5th, 2018
ALS Therapy Development InstituteCambridge, MABA or BSALSJan 05, 2018
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