Figure 3. Expression of oligodendrocyte-specific cell type markers in F3.Olig2 cells and expression of motor neuron-specific cell type markers in F3.Olig2-Shh cells.
Image credit: Lee, et.al. 2014 under CC BY license

Job Opportunities

To submit any new job opportunities for this list, please email ALSjobs@prize4life.org. List the employer, location, closing date if applicable, and a link to more information. Jobs are removed after 3 months, unless requested otherwise.

This free job bulletin board aims to help scientists identify job opportunities in the field of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Positions described as broadly spanning neurodegenerative diseases (NDG) are noted as ‘NDG‘. The job listing includes research positions at all levels, as well as non-research positions for which a research background at the MS, PhD, or MD level is required.


Click the title of any table column to sort.

Academia

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Postdoctoral Fellow, Bonanomi Lab

Postdoctoral Fellow, Bonanomi Lab

(Click title to open job details in a new window.)
Description:

Two postdoctoral positions are available in the laboratory of Molecular Neurobiology at San Raffaele Institute in Milan to study development and degeneration of spinal motor neurons using mouse genetics, cellular approaches, and advanced genomic/proteomic techniques. The San Raffaele Institute is an international biomedical center with well-integrated basic and translational programs, offering a vibrant research environment and state-of-the-art platforms.


Our laboratory is supported by the ERC and the Armenise-Harvard Foundation to investigate the molecular and cellular underpinnings of neuronal connectivity and how these processes are deregulated in disorders of the spinal motor system that controls movements. Current projects focus on (i) mechanisms of axon pathfinding and neuronal morphogenesis; (ii) neurovascular interactions in the developing nervous system and nerve regeneration; (iii) the molecular basis of motor neuron diseases, including Amyotrophic Lateral Sclerosis (ALS). Please visit the lab website for further information: http://www.hsr.it/research/organization/divisions-centers/division-of-neuroscience/molecular-neurobiology/


We are seeking highly motivated, interactive and creative individuals with a PhD and proven track record of research and publications in a relevant area of biological sciences – molecular neuroscience, developmental and cell biology, neurovascular signaling, neurodegenerative diseases. Candidates with a strong background in endothelial biology who want to explore the crosstalk between neuronal and vascular systems in development and neurological disorders are also welcome to apply. Experience in bioinformatics is a plus.


The appointments are available immediately and applications will be considered until the positions are filled. This is an excellent opportunity for talented and driven individuals who want to perform cutting edge research at the intersection of basic and translational molecular neuroscience and neurovascular biology.


Applicants should submit a CV and cover letter with a summary of previous work and future research interests, along with contacts of 2 references to: Dario Bonanomi (bonanomi.dario@hsr.it)


Link: https://www.nature.com/naturejobs/science/jobs/627021-postdoctoral-positions-in-molecular-neurobiology
Employer: San Raffaele Institute
Location: Milan, Italy
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: October 16th, 2017
Applications close: December 15th, 2017
San Raffaele InstituteMilan, ItalyPhDALSOct 16, 2017
NEW! Research Scientist, Gao Lab

Research Scientist, Gao Lab

(Click title to open job details in a new window.)
Description:

A position at the junior postdoctoral or Research Scientist level is immediately available in the laboratory of Dr. Fen-Biao Gao at the University of Massachusetts Medical School to study molecular pathogenic mechanisms of fronototemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) (Lu et al., Mol. Cell 2013; Gascon et al., Nat. Med. 2014; Freibaum*, Lu* et al., Nature 2015; Tran et al., Neuron 2015; Lopez-Gonzalez et al., Neuron 2016). Candidates with strong research experience in mouse genetics and molecular and cellular biology are encouraged to apply. Interested please send CV to fen-biao.gao@umassmed.edu


Link: https://www.nature.com/naturejobs/science/jobs/627025-junior-postdoctoral-or-research-scientist-umass-medical-school
Employer: University of Massachusetts Medical School
Location: Worcester, MA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: October 16th, 2017
Applications close: December 15th, 2017
University of Massachusetts Medical SchoolWorcester, MAPhDALSOct 16, 2017
NEW! Senior Research Investigator

Senior Research Investigator

(Click title to open job details in a new window.)
Description:

We are currently looking for Senior Research Investigator (SRI), Translational Research, to work in one of the several therapeutic areas we work with such as motor neuron, neurodegenerative, and lysosomal storage diseases.


As an SRI, Translational Research, you will be involved in translational research projects in one or more therapeutic areas. In each case, you will be working in the setting of large interdisciplinary teams, where you will function independently in the execution of the experiments but will need to work collaboratively with other team members. Working independently, you will perform design, optimization, and implementation of complex in vitro and in vivo experiments in rodents and NHP within specified timelines; provide cross-organizational support for the essential laboratory functions, including effective management of laboratory resources, and participation in maintenance of centralized reagents; contribute to writing/reviewing manuscripts, preparing presentations, establishing collaborations as well as writing/reviewing protocols and SOPs.


Link: https://www.linkedin.com/jobs/view/308194466/
Employer: University of Pennsylvania School of Medicine
Location: Philadelphia, PA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: October 12th, 2017
University of Pennsylvania School of MedicinePhiladelphia, PAPhDNDGOct 12, 2017
NEW! Research Technician

Research Technician

(Click title to open job details in a new window.)
Description:

The VIB-KU Leuven Center for Brain & Disease Research is part of the VIB Life Sciences Institute and is embedded within the University of Leuven, which ranks among the world’s top 50 universities. At our center, researchers want to force a breakthrough in the cure of neuronal and neurodegenerative disorders. This requires a deep understanding of normal brain function and translation of this knowledge into a solid mechanistic understanding of disease mechanisms.


Our center is committed to translate basic research findings into value for society. We are looking for a highly motivated and flexible research technician to support translational research projects in our center. This entails the development of disease targets, setting up screening assays and coordinating interactions with the drug discovery unit of the institute.


Link: https://www.nature.com/naturejobs/science/jobs/619293-research-technician-translational-research-projects
Employer: VIB
Location: Ghent, Belgium
Sector: Academia
Degree required: BA or BS
Conditions: NDG
Job posted: October 11th, 2017
Applications close: December 11th, 2017
VIBGhent, BelgiumBA or BSNDGOct 11, 2017
NEW! Postdoctoral Fellow, Pathology

Postdoctoral Fellow, Pathology

(Click title to open job details in a new window.)
Description:

This position is funded by ForeFront, an NHMRC Program grant, that brings together a multidisciplinary research team to address the diagnosis, management and treatment of frontotemporal dementia and related disorders. A junior postdoctoral researcher is required to contribute to projects exploring the pathogenesis of neurodegeneration with a particular focus on immune-mediated mechanisms. This is a valuable opportunity to expand your research skills.


Full-time fixed term up until 31st December 2018 with possibility of renewal up to five years. Remuneration package: $106K – 114K p.a. which includes base salary $90K – $96K, leave loading and up to 17% superannuation


Main Responsibilities Will Be To

*assist with the development of new projects investigating inflammatory aspects of neurodegeneration

*undertake data collection and analysis.


About You

The University values courage and creativity; openness and engagement; inclusion and diversity; and respect and integrity. As such, we see the importance of recruiting talent aligned to these values and are looking for a Postdoctoral Research Associate to support the Neuropathology team who will:

*contribute to the development of research projects in the area of neurodegenerative disorders

*assist other researchers and students with various tasks including data collection and analysis

*prepare and contribute to publications, presentations and reports

*contribute to grant applications

*co-ordinate various administrative tasks associated with research projects.


To Succeed In This Role You Will Have

*a PhD in any field relevant to pathology, or related discipline

*previous research experience including skills in immunology or related field

*demonstrated contributions to peer reviewed publications

*clear career goals to develop a nationally competitive research profile.


The successful applicant will be able to collaborate with other groups within the ForeFront team and contribute to research outcomes of the program. Strong communication and interpersonal skills are essential as is a sound basis in responsible research conduct. The opportunity also exists to contribute to the supervision of research students and develop skills in neuropathology.


Intending applicants are welcome to seek further information about the position from Professor Jillian Kril on 02 9036 7118.


For recruitment-related enquiries, or if you require reasonable adjustment or support filling out this application, please contact Melanie Leshetz on 02 8627 1220 or melanie.leshetz@sydney.edu.au


Link: https://www.linkedin.com/jobs/view/473811164/
Employer: University of Sydney
Location: Sydney, Australia
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: October 10th, 2017
University of SydneySydney, AustraliaPhDALS, FTDOct 10, 2017
NEW! Research Associate, Neuroimaging

Research Associate, Neuroimaging

(Click title to open job details in a new window.)
Description:

One Research Associate position is currently available at the Laboratory of Neuro Imaging in the area of neuroimaging genetics, involving the development of algorithms for the identification of novel multimodal (imaging and genetic) feature combinations and models that explain such imaging-genetic interactions and facilitate diagnoses and prognoses in neuropsychiatric, neurodegenerative, and neurodevelopmental brain disorders. Additional responsibilities will be to train student researchers and interact with other laboratory assistants on common projects. Other key responsibilities will be documentation of procedures using word processing, data base and web-based applications, and supervised statistical analyses, figure and table preparation for various manuscripts and scientific presentations. The successful candidate will have a strong background in multimodal brain image analysis, large-scale genetic association study and statistical modeling. Knowledge of neuroanatomy and basic neuroscience, computer programming experience (working knowledge of Linux, Matlab, R, Python, C/C++, etc.) and excellent communication and writing skills are desired. Experience on database, bioinformatics, graphical models, dimensionality reduction, and machine learning is desirable.


Minimum Education: Ph.D. or equivalent doctorate

Minimum Experience: 1 year

Minimum Field of Expertise: Directly related education and experience in research specialization with advanced knowledge of equipment, procedures and analysis methods.


Link: https://usccareers.usc.edu/job/-/-/1209/5930770
Employer: University of Southern California
Location: Los Angeles, CA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: October 9th, 2017
University of Southern CaliforniaLos Angeles, CAPhDNDGOct 09, 2017
NEW! Assistant Professor, Medicinal Chemistry

Assistant Professor, Medicinal Chemistry

(Click title to open job details in a new window.)
Description:

The University of Illinois at Chicago, College of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy seeks candidates for a full-time, tenure-track faculty position at the rank of Assistant Professor. Successful candidates will have the potential to develop and maintain a strong, extramurally funded, independent research program.


Duties:

The new faculty is expected to establish strong collaborations with the department faculty and play an active role in the UICentre for Drug Discovery. Teaching in the professional and graduate programs of the College of Pharmacy is required.


Qualifications:

A PhD degree in Synthetic Organic or Medicinal Chemistry or related discipline and relevant postdoctoral experience are required. Priority will be given to research in synthetic medicinal chemistry, preferably in the area of cancer, neurodegenerative diseases and/or the human microbiome.


Job ID #86425


Link: https://jobs.uic.edu/job-board/job-details?jobID=86425
Employer: University of Illinois
Location: Chicago, IL
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: October 8th, 2017
Applications close: November 13th, 2017
University of IllinoisChicago, ILPhDNDGOct 08, 2017
Assistant, Associate, Full Professor, Pathology and Cell Biology

Assistant, Associate, Full Professor, Pathology and Cell Biology

(Click title to open job details in a new window.)
Description:

The Department of Pathology and Cell Biology at the Columbia University Medical Center seeks highly qualified individuals for faculty positions in surgical pathology, clinical pathology and research. Appointments can be at the Instructor, Assistant, Associate, Professor, or Associate Research Scientist level depending on experience and qualifications. All positions require outstanding academic credentials and a record of scholarly productivity. Clinical positions require board certification and a license in NYS. Columbia University’s Department of Pathology & Cell Biology invites applications for a junior/senior level faculty position. Candidates should have a strong record of research and teaching qualifications (distinction). Candidates will be expected to sustain an active research and publication portfolio and supervise graduate students, and fellows. Candidate will play a vital role in Departmental activities.


Minimum Qualifications: Depending on the field of research and current needs for field and instructional coverage within the department, certain subspecialties may be preferred. Current research specialties: Cancer Biology, Neurodegenerative diseases, Cellular and molecular neurobiology, Cell motility, cytoskeleton and intracellular trafficking, Virology, Neuronal stem cells.


Preferred Qualifications: Depending on the field of research and current needs for field and instructional coverage within the department, certain subspecialties may be preferred.


Link: https://main.hercjobs.org/jobs/10351210/instructor
Employer: Columbia University
Location: New York, NY
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: October 6th, 2017
Columbia UniversityNew York, NYPhDNDGOct 06, 2017
Cognitive Clinical Research Nurse

Cognitive Clinical Research Nurse

(Click title to open job details in a new window.)
Description:

The Cognitive Clinical Research Nurse is responsible to promote organizational values of patient and visitor satisfaction by demonstrating courtesy and respect for families, visitors and other employees. Cares for patients in all age groups from young adult through geriatrics. Demonstrates competence in the assessment, treatment and care of patients serviced. Works in collaborative practice setting with supervising/collaborating physicians to care for patients within the Penn Frontotemporal Degeneration Center.


Responsible for the plan of care and utilizing the nursing process in the delivery of care in conjunction with treating physicians and nurse. The nurse will facilitate the coordination of care, and demonstrate safe practice within the domains of clinical judgment and decision making, nurse-patient/family relationship, clinical leadership and clinical scholarship.


Responsible as well for coordination of nursing component of clinical research activities within the Penn Frontotemporal Degeneration Center. Provides specialized education and oversight concerning research studies and facilitates the conduct of those clinical research assigned within the Center. Duties include informed Consent, the precise collection and data entry of study, and department related information and activities into appropriate data bases. Interaction with primary investigators and study team members during IRB submissions. Helps completes Investigational Drug and Device FDA paperwork related to assigned research projects. Participates in direct patient care within the scope of clinical research protocols. Assists in new protocol development, Grant submissions and Quality Control.


Link: https://careers.peopleclick.com/careerscp/client_pennmedicine/external/gateway/viewFromLink.html?jobPostId=67899&localeCode=en-us&source=LinkedIn&sourceType=PREMIUM_POST_SITE
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: RN
Conditions: FTD
Job posted: October 6th, 2017
University of PennsylvaniaPhiladelphia, PARNFTDOct 06, 2017
Postdoctoral Fellow, Boulis Lab

Postdoctoral Fellow, Boulis Lab

(Click title to open job details in a new window.)
Description:

The Boulis laboratory in the department of Neurosurgery at Emory University in Atlanta, GA, is seeking a capable and self-motivated individual to oversee projects involving the transplantation of iPS cells for the treatment of motor neuron diseases and nerve damage.


The candidate should hold a Ph.D. in an appropriate field and have a strong publication record in neuroscience and related fields. The ideal candidate will have experience with creating iPS cells from human and rodent cells and differentiating them into motor neurons. The candidate should also have excellent oral and written communication skills and the ability to work as part of a team. Experience working with rodent models is preferred. Salary and title will be commensurate with experience


To apply for this position, please go to Emory’s Career page and job requisition #76107BR – Assistant Academic Research Scientist.


https://sjobs.brassring.com/TGnewUI/Search/Home/Home?partnerid=25066&siteid=5043#home


Link: https://sjobs.brassring.com/TGnewUI/Search/Home/Home?partnerid=25066&siteid=5043#home
Employer: Emory University
Location: Atlanta, GA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: October 4th, 2017
Emory UniversityAtlanta, GAPhDALSOct 04, 2017
Research Scientist, Pathology

Research Scientist, Pathology

(Click title to open job details in a new window.)
Description:

The Department of Pathology currently has an outstanding opportunity for a Research Scientist/Engineer 2. Under the general direction of the PI, this position provides comprehensive research to develop biomarkers for the diagnosis and staging of neurodegenerative diseases, and for the evaluation of potential disease modifying agents.


Research focuses for this position include but are not limited to:


*Support protein expression, purification, and post-translational modification efforts

*Investigate underlying pathological mechanisms

*Identify and evaluate the roles of key biomarkers in the disease process

*Demonstrate a mastery of major immunologically based technologies; Qiagen’s Luminex, Meso *Scale Discovery’s, electro chemiluminescent detection and Simoa’s Quanterix platforms.

*Develop and validate immune-assays for candidate biomarkers

*Conduct immune-assays using major immunologically based technologies

*Contribute to the design and execution of cell and tissue based studies to investigate biological mechanisms of neurodegeneration

*Collect and acquire human clinical biological samples


Responsibilities:


Masters in any related Life science, Biomedical Engineering or Chemistry And two to four years’ experience or an equivalent education and experience.


Working knowledge of ELISA and/or other immunologically based assay; Protein expression, purification and post-translational modifications. Cell and/or tissue based studies.


Link: https://main.hercjobs.org/jobs/10345439/research-scientist-engineer-2
Employer: University of Washington
Location: Seattle, WA
Sector: Academia
Degree required: MS
Conditions: NDG
Job posted: October 4th, 2017
University of WashingtonSeattle, WAMSNDGOct 04, 2017
Postdoctoral Fellow, Xia Lab

Postdoctoral Fellow, Xia Lab

(Click title to open job details in a new window.)
Description:

A research lab at the University of Central Florida Medical College invites you to apply for post-doctoral associate position. Research in the lab is focused on the genetic and molecular mechanisms of neurodegeneration in amyotrophic lateral sclerosis and Parkinson’s disease. Our team has published our findings in Acta Neuropath, EMBO J, the Journal of Clinical Investigation, PLoS Genetics, and PNAS. Post-doctors being recruited will help validate the pathogenic role of genetic mutations newly discovered in the lab using cell culture and animal models. The research lab is located at the UCF Burnett School of Biomedical Sciences at the Lake Nona campus. Researchers who have recently obtained their PhD degrees and seek to further develop their academic career are encouraged to apply for the positions. Please email your CV to Dr. Xugang Xia at xugang.xia@ucf.edu


Link: http://neurojobs.sfn.org/jobs/10337854/post-doctoral-associate
Employer: University of Central Florida
Location: Orlando, FL
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: October 3rd, 2017
University of Central FloridaOrlando, FLPhDALSOct 03, 2017
Research Fellow, McCormick Lab

Research Fellow, McCormick Lab

(Click title to open job details in a new window.)
Description:

We are seeking a Research Fellow in the Department of Biomedical Sciences to commence as soon as possible.The main focus of this research is to determine whether the human endogenous retrovirus HERV-K contributes to sporadic Amyotrophic Lateral Sclerosis (sALS)/ Motor Neurone Disease, as suggested in a ground-breaking study by Li et al (Sci Transl Med. 2015 Sep 30; 7 (307):307ra153). The successful candidate will develop and standardise HERV-K and HERV-W specific qPCR assays that are MIQE compliant, to measure expression levels of HERV transcripts in human post-mortem brain and blood from patients and controls. Next generation sequencing (NGS) will also be performed to look for HERV-K sequence variants associated with sALS and digital PCR will be employed to measure HERV-K DNA copy number. Optionally, microarray analysis may be undertaken to provide a broader screening of HERV expression patterns. The research proposed will allow us to gain a better understanding of sALS pathogenesis and may provide novel diagnostic markers and targets for treatment development and monitoring in this fatal neurological disease.


The post is based within Dr Adele McCormick’s group in the Faculty of Science and Technology (University of Westminster). The research will be undertaken in close collaboration with Professor Ammar Al-Chalabi (Maurice Wohl Clinical Neuroscience Institute, King’s College London), Dr Jeremy Garson (Division of Infection and Immunity, University College London) and Dr Jim Huggett (LGC Group, Teddington).


Candidates must hold a PhD in virology/molecular biology or the equivalent in professional qualifications and experience. Candidates must also have a proven record of successful research with experience of real-time qPCR and NGS. Knowledge of bioinformatic software packages would also be desirable.


Administrative contact (for queries only): Recruitment@westminster.ac.uk


Job reference number: 50046026


Closing date: 27 October 2017


Interviews are likely to be held on: W/C 30 October 2017


Link: https://vacancies.westminster.ac.uk/Hrvacancies/default.aspx?id=50046026
Employer: University of Westminster
Location: London, England
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: October 3rd, 2017
Applications close: October 27th, 2017
University of WestminsterLondon, EnglandPhDALSOct 03, 2017
Assistant and Associate or Full Professor, Neurodegeneration and Neurotherapeutics

Assistant and Associate or Full Professor, Neurodegeneration and Neurotherapeutics

(Click title to open job details in a new window.)
Description:

Duke University invites applications for potential tenure-track faculty members to join our newly established Duke Center for Neurodegeneration and Neurotherapeutics, which will be directed by Dr. Al La Spada. In the academic year 2017-18, we are searching for talented investigators to fill two faculty positions. Appointments may be at any level, with an expectation that one position will be filled by an early-stage investigator who would start his/her independent career at Duke, and one position will be filled by a mid-career investigator at the Associate Professor rank or a senior investigator at the Professor rank.


Ideal applicants will be employing genetic, molecular, cellular, and/or neurobiological approaches to the study of neurodegenerative diseases, including especially Alzheimer’s disease, Parkinson’s disease, ALS, or frontotemporal dementia. Successful candidates will have track records of creativity and productivity, demonstrated potential for outstanding future achievement, and a desire to participate in an exciting, interactive, and growing neuroscience and neurological disease research community. All Center faculty will be expected to mount a productive and innovative research program, obtain extramural funding, and actively participate in graduate student, medical student, and postdoctoral fellow education. Candidates must hold a Ph.D., M.D., M.D.-Ph.D., or equivalent degree(s). Qualified women and minority candidates are especially encouraged to apply.


For full consideration, applications should be submitted by November 30th, 2017, although applications will be considered until the initial two positions are filled. Applicants should submit a curriculum vitae, a brief summary of current and proposed research, reprints of 3 key publications, and 3 letters of recommendations.


Submit the following items online at this website to complete your application:

Cover Letter

Curriculum Vitae

Research Statement

Three Reference Letters


Questions may be directed to Al La Spada, Director of the Duke Center for Neurodegeneration and Neurotherapeutics: al.laspada@duke.edu


Link: https://academicjobsonline.org/ajo/jobs/9990
Employer: Duke University Medical Center
Location: Durham, NC
Sector: Academia
Degree required: PhD, MD or MD/PhD
Conditions: ALS, FTD
Job posted: September 29th, 2017
Applications close: November 30th, 2017
Duke University Medical CenterDurham, NCPhD, MD or MD/PhDALS, FTDSep 29, 2017
Postdoctoral Fellow

Postdoctoral Fellow

(Click title to open job details in a new window.)
Description:

The international “Regulatory T cell responses at the crossroads of immune homeostasis and inflammation in the context of barrier diseases” (TregBar) project is an international research project funded by the Luxembourg National Research Fund`s (FNR) bilateral AFR funding instrument. The program will initiate long-term collaborations between the biomedical initiatives of the Luxembourg Institute of Health (Esch-sur-Alzette, Luxembourg) and the Luxembourg Centre for Systems Biomedicine of the University of Luxembourg with the RIKEN Center for Integrative Medical Sciences (IMS) in Yokohama, Japan.


To address the open questions on the balance of the immune system, the project will investigate functional gene regulatory and signaling networks of regulatory Tregs in the context of several barrier diseases by using various murine and human disease models. For this purpose, the collaborative project will combine expertises in basic immunology especially on Tregs, microbiome, single cell analysis, clinical immunology, deep immune phenotyping and computational network analysis.


The successful candidate will therefore work in strong collaboration with different groups and perform single cell transcriptomics analysis using our established DropSeq pipeline and Fluidigm platform to investigate underlying molecular mechanisms of the immune system. The candidate will also spend up to 6 month at the RIKEN institute in Yokohama for additional training on disease models.


Link: https://jobs.sciencecareers.org/job/464797/postdoctoral-researcher-position-research-associate-in-systems-biomedicine-m-f-/
Employer: University of Luxembourg
Location: Esch-sur-Alzette, Luxembourg
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: September 29th, 2017
University of LuxembourgEsch-sur-Alzette, LuxembourgPhDNDGSep 29, 2017
Research Technician, Maniatis Lab

Research Technician, Maniatis Lab

(Click title to open job details in a new window.)
Description:

The Maniatis lab iat CUMC is seeking a highly motivated Technician B to work on a project focusing on the role of innate immunity and autophagy pathways on the progression of the neurodegenerative disease Amyotrophic Lateral Sclerosis (ALS). The technician will work closely with colleagues using techniques such as gene expression profiling, in vitro cell culture assays, and in vivo mouse genetics.


Principal Responsibilities:

Cell culture and Western blotting to study protein-protein interactions; Real-time PCR analysis of gene expression; General molecular cloning techniques for the production of recombinant plasmids and proteins; Genotyping and general maintenance of mouse colony; Sectioning and antibody staining of tissues for gene expression analysis; CRISPR experiments to generate genetically modified human and mouse cells.


Link: https://main.hercjobs.org/jobs/10325769/technician-b
Employer: Columbia University
Location: New York, NY
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: September 29th, 2017
Columbia UniversityNew York, NYBA or BSALSSep 29, 2017
Research Assistant, MND

Research Assistant, MND

(Click title to open job details in a new window.)
Description:

We are seeking a Research Assistant in Motor Neuron Disease to join the Nuffield Department of Clinical Neurosciences (NDCN). The post offers the opportunity to become proficient in the culture of fibroblasts, and motor and cortical neurons from iPSCs and to gain experience in neurodegeneration research as it relates to motor neuron disease (amyotrophic lateral sclerosis). As such the post would be very suitable for a bioscience graduate who is considering going on to study for a doctorate in neuroscience.


Your key responsibilities include, but are not limited to: the provision of research support for the Motor Neuron Disease research group, contributing to: the maintenance and analysis of neuronal cultures derived from induced pluripotent stem cells (iPSCs) from patients seen in the Oxford Motor Neuron Disease clinic; the processing and biobanking of biosamples (blood, urine, cerebrospinal fluid and skin biopsies) from patients participating in a major biomarker research project entitled ‘A Multicentre Biomarker Resource Strategy in ALS’ (AMBRoSIA).


You will have experience of following and adapting laboratory protocols and selecting appropriate experimental methodologies, pursue a degree in a relevant discipline (e.g. biological sciences, including neuroscience), possess sufficient specialist knowledge in the discipline to work within the established research programmes, along with excellent communication skills, including the ability to write text that can be published, present data at conferences, and represent the research group at meetings.


The post is full-time for a fixed-term of 1 year (12 months) in the first instance.


Only applications received before 12.00 midday on Thursday 19 October 2017 will be considered.


Link: https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.display_form?p_internal_external=E&p_applicant_no=&p_form_profile_detail=&p_recruitment_id=131289&p_display_apply_ind=Y&p_company=10&p_process_type=&p_display_in_irish=N&p_refresh_search=Y
Employer: University of Oxford
Location: Oxford, England
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: September 28th, 2017
Applications close: October 19th, 2017
University of OxfordOxford, EnglandBA or BSALSSep 28, 2017
Research Specialist, Grossman Lab

Research Specialist, Grossman Lab

(Click title to open job details in a new window.)
Description:

A full-time position is available in the laboratory of Dr. Murray Grossman in the Department of Neurology at the University of Pennsylvania. This lab focuses on cognitive neuroscience and clinical questions relating to language, memory, and neurodegenerative disease (e.g., primary progressive aphasia, behavioral variant frontotemporal degeneration, Alzheimer’s). Applicant responsibilities will include the collection and analysis of PET scan data, and the collection and analysis of structural MRI data. This position will provide a strong foundation for individuals interested in continuing their education in graduate or medical school.


Link: https://main.hercjobs.org/jobs/10314223/research-specialist-a
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: BA or BS
Conditions: FTD
Job posted: September 26th, 2017
University of PennsylvaniaPhiladelphia, PABA or BSFTDSep 26, 2017
Research Associate, Svendsen Lab

Research Associate, Svendsen Lab

(Click title to open job details in a new window.)
Description:

The Svendsen Laboratory at the Cedars-Sinai Regenerative Medicine Institute is looking 1hr personnel to join our dynamic group. The incumbent should have an interest in the basic science of stem cells and neuroscience. By understanding how the cells grow and differentiate we will be able to produce a better cell for transplantation and develop techniques for disease modeling. The laboratory technician will, under the direction of the P1, lab manager and project scientist, assist in the conduct of research in Amyotrophic Lateral Sclerosis (ALS).


Working under direct supervision, the Research Associate I performs a variety of routine experimental protocols and procedures to support the objectives of one or more laboratory research projects in a specific area of research. Assists in general laboratory activities, including maintenance of reagents and stocking of supplies. Files and monitors documents. Keeps accurate and detailed records of experiments and results, Assists in the operation of specialized equipment and machinery. Observes safety standards and procedures. The Research Assistant 1 will be able to perform routine cellular, micro- and molecular biology procedures including, but not limited to Western, Northern blot, DNA/RNA, PCR. protein extraction, cell culture. Immunohistochemistry, and staining. This position does not have supervisory responsibilities.


Link: https://www.cedars-sinaimedicalcenter.apply2jobs.com/ProfExt/index.cfm?fuseaction=mExternal.showJob&RID=27365&CurrentPage=37
Employer: Cedars Sinai Medical Center
Location: Los Angeles, CA
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: September 21st, 2017
Cedars Sinai Medical CenterLos Angeles, CABA or BSALSSep 21, 2017
Assistant Professor, Neurobiology and Behavior

Assistant Professor, Neurobiology and Behavior

(Click title to open job details in a new window.)
Description:

We seek outstanding candidates whose research addresses the molecular neuropathology of Alzheimer’s disease and other neurodegenerative disorders. Preference will be given to applicants whose research integrates cutting edge neuroscientific techniques using human and animal tissue. Applicants should hold a Ph.D., M.D., or equivalent degree, seek to establish a vigorous and highly competitive research program, and to contribute to teaching at both the graduate and undergraduate levels. Please submit by October 24th, 2017, curriculum vitae, a description of research and teaching interests, and the names and addresses of three potential referees. A separate statement that addresses past and/or potential contributions to diversity, equity and inclusion should also be included in the application materials. Criteria for research, teaching, and diversity statement is available here: http://sites.bio.uci.edu/wp-content/uploads/2017/09/NBB_asst_prof_Statement_Criteria.pdf. For application instructions, please go to the Department of Neurobiology and Behavior Assistant Professor section at https://recruit.ap.uci.edu/apply/JPF04238.


Link: https://recruit.ap.uci.edu/apply/JPF04238
Employer: University of California
Location: Irvine, CA
Sector: Academia
Degree required: PhD or MD
Conditions: NDG
Job posted: September 20th, 2017
Applications close: October 24th, 2017
University of CaliforniaIrvine, CAPhD or MDNDGSep 20, 2017
Postdoctoral Fellow, Ward Lab

Postdoctoral Fellow, Ward Lab

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Description:

A postdoctoral position in cell biology and neurodegenerative diseases is available in the lab of Dr. Michael Ward, National Institute of Neurological Disorders and Stroke (NINDS), Neurogenetics Branch, in Bethesda MD. The Ward lab utilizes human iPSC-derived neurons to study basic mechanisms of neurodegeneration. By combining forward-genetics, proteomics, and molecular/biochemical techniques, we seek to identify converging disease pathways that underlie inherited neurodegenerative diseases. In parallel, we pursue complimentary drug discovery approaches using ultra high-content small molecule screens with colleagues in the National Center for Advancing Translational Sciences (NCATS).


Salary, benefits, and travel opportunities (if applicable) will be commensurate with experience and qualifications.


Qualifications:


Candidates should have a Ph.D., M.D. or equivalent degree, less than 4 years of post-doctoral experience, and expertise in cell biology, molecular biology, biochemistry, microscopy.


Additional skills in bioinformatics, programming, and/or stem cell biology are preferred. Candidates should have excellent writing and communication skills, and an outstanding publication record.


To apply: Interested candidates should send a cover letter, curriculum vitae, bibliography, and contact information of three references to: Michael Ward: wardme@nih.gov


Link: http://neurojobs.sfn.org/jobs/10249689/postdoctoral-position-cell-biology-neurodegenerative-diseases-ward-lab-ninds-nih
Employer: NINDS
Location:
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: September 19th, 2017
NINDSPhDNDGSep 19, 2017
Junior or Senior Group Leader

Junior or Senior Group Leader

(Click title to open job details in a new window.)
Description:

The Grenoble Institute of Neurosciences (GIN), an outstanding research center devoted to understanding brain functions and the development of innovative clinical therapies for neurological, neuromuscular and psychiatric disorders, is welcoming applications for positions as junior and senior group leaders in basic and/or clinical research.


The GIN has more than 6.000 m2 dedicated to research in Neuroscience in close proximity to many high level research centers, offering a unique opportunity for the development of trans-disciplinary projects. Eleven research teams host 240 researchers, clinicians, students and technicians. The GIN is equipped with state-of-the-art technology platforms such as MRI, EEG, TMS, a photonic imaging center (PIC-GIN), and electron microscopy providing the necessary resources for high standard and innovative research.


Research at the GIN spans from brain development to adult brain plasticity, from the molecular to the most integrated levels, using cell lines, animal models and clinical trials. Currently studied pathologies of the adult nervous system include Parkinson’s, Huntington’s and Alzheimer’s diseases, epilepsy, vascular disorders, mood and anxiety disorders.


For further information visit: http://neurosciences.univ-grenoble-alpes.fr/


The GIN is a founfing member of the project GREEN (GREnoble Excellence in Neurodegeneration – https://green.univ-grenoble-alpes.fr), a center of excellence in the field of neurodegenerative disorders (COEN).


The candidates are expected to develop an independent and high quality research program within the Institute.


Junior positions: the Institute is offering a start-up package and laboratory space for up to 6 persons. Candidates should hold a PhD and/or an MD degree, have strong postdoctoral experience and meet criteria to obtain national (ANR, Atip-Avenir, FRM Amorçage, etc.) and international funding, and a French research institutional position (Inserm, CNRS).


Senior positions: the Institute is offering a start up package and laboratory space for up to 12 persons. Candidates should have previous experience as principal investigator of research projects with national and/or international funding, and hold a French institutional research position (Hospital, University, Inserm, CNRS).


Applications (in English) should be sent before December 1st, 2017 to gin-direction@ujf-grenoble.fr. A single pdf file should include a curriculum vitae with the list of publications, names and addresses of three references (3 pages max), a brief description of research accomplishments and research plans for the next 5 years (5 pages max).


Junior positions: Candidates should hold a PhD and/or an MD degree, have strong postdoctoral experience and meet criteria to obtain national (ANR, Atip-Avenir, FRM Amorçage, etc.) and international funding, and a French research institutional position (Inserm, CNRS).


Senior positions: Candidates should have previous experience as principal investigator of research projects with national and/or international funding, and hold a French institutional research position (Hospital, University, Inserm, CNRS).


Link: http://neurojobs.sfn.org/jobs/10278726/call-for-junior-and-senior-leaders
Employer: Grenoble Institute of Neurosciences
Location: Grenoble, France
Sector: Academia
Degree required: PhD and/or MD
Conditions: NDG
Job posted: September 15th, 2017
Grenoble Institute of NeurosciencesGrenoble, FrancePhD and/or MDNDGSep 15, 2017
Director, Center for Neurodegenerative Disorders

Director, Center for Neurodegenerative Disorders

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Description:

The University of Maryland Department of Neurology is seeking a senior level physician scientist with expertise in dementia and neurodegeneration to serve as the Director of the Center for Neurodegenerative Disorders. Specifically, the Department is seeking an investigator with a strong history of external funding whose work focuses on the molecular and cellular pathogenesis of neurodegenerative disorders including Alzheimer’s disease (AD), Huntington’s disease (HD), Fronto-temporal dementia (FTD), or hereditary ataxias (HA).

S/he should have expertise in molecular genetics including whole genome or whole exome screening, SNP or CGA array analysis as a means to identify novel genes that are causative for neurodegenerative disorders in human patients or to screen modifier loci associated with phenotypic variability.

The selected candidate should be clinically trained in cognitive neurology or a related discipline and should be willing to see patients with neurodegenerative disorders such as dementia in the outpatient neurology setting.


For complete details or to apply, contact Lexi Cejka at Lexi.Cejka@grantcooper.com.


Link: https://main.hercjobs.org/jobs/10275358/director-of-center-for-neurodegenerative-disorders-neurology
Employer: University of Maryland
Location: Baltimore, Maryland
Sector: Academia
Degree required: MD
Conditions: NDG
Job posted: September 14th, 2017
University of MarylandBaltimore, MarylandMDNDGSep 14, 2017
Assistant Director, Aging Brain Initiative

Assistant Director, Aging Brain Initiative

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Description:

The Aging Brain Initiative, led by Picower Institute Director Li-Huei Tsai, is an MIT–wide effort to understand dementia—why it begins and progresses and how we can stop it. This effort distinguishes itself by focusing on Alzheimer’s disease as a whole-systems failure, and not the result of a single flawed component. The initiative is looking at the interactions of brain circuits with whole systems throughout the brain. MIT’s strength in computer science and engineering as well as in bioscience and neuroscience will be brought to bear on this critical contemporary human problem.


The Assistant Director will work with the Director and founding members to build this Initiative into a world-class enterprise. Specifically, s/he will assist the Director in developing its vision, strategy, operations, communications, outreach, and fundraising activities.


Strategic Planning and Operations


•To collaborate with the director to develop and shepherd the vision of the Initiative: support Principal Investigators’ (PIs) processes in defining and developing the scientific, educational and translational vision for the Initiative, and implementation in collaboration with the Director and Initiative PIs.

•Direct and implement effective strategic planning efforts for resource allocation, operational structures, and procedures to accomplish the research goals established by the Director. Work with PIs on individual research programs as well as Initiative-wide activities. Facilitate research collaborations among PIs.

•Monitor and evaluate Aging Brain Initiative processes. Oversee and produce timely deliverables and accurate data reporting on progress and new strategic directions.

•Prepare reports, presentations, outreach documents, grants and fundraising proposals for distribution to donors, foundations, scientists, and others. Coordinate communication efforts.

•Organize internal and external scientific meetings, conferences, seminars, and other events, and supervise their execution. Help set agendas for effective internal team meetings and then follow-up on action items to insure execution.

•Partner with the Director of Development to identify strategic fundraising priorities and secure funding.

•Monitor finances: help oversee and track budget projections with the Director; provide day-to-day financial reporting mechanisms in coordination with the Picower Institute Headquarters staff.

•Perform other responsibilities as necessitated by the position or as assigned by the Director.


Link: https://jobs.sciencecareers.org/job/462877/assistant-director-aging-brain-initiative/
Employer: MIT
Location: Cambridge, MA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: September 13th, 2017
Applications close: October 25th, 2017
MITCambridge, MAPhDNDGSep 13, 2017
Postdoctoral Fellow, Fitzpatrick Lab

Postdoctoral Fellow, Fitzpatrick Lab

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Description:

The Fitzpatrick lab, a member of the Mortimer B. Zuckerman Mind Brain Behavior Institute at Columbia University in the City of New York (https://zuckermaninstitute.columbia.edu/), has openings for four postdoctoral scientists opportunities.


Situated in the heart of Manhattan, at full capacity the Zuckerman Institute will house up to sixty laboratories employing a broad range of interdisciplinary approaches to transform our understanding of the mind and brain. In this highly collaborative environment, labs work together to gain critical insights into human health by exploring how the brain develops, performs, endures and recovers from trauma or disease.


In our lab, we leverage the latest developments in cryo-electron microscopy with complementary biophysical techniques (proteomics, light-microscopy, microfluidics) to explore the molecular basis of neurodegeneration (e.g. PNAS 110, 5468-5473 and Nature 547, 185-190). To this end, we determine the structure and function of protein complexes, purified directly from postmortem brain tissue, that are implicated in a range of neurodegenerative diseases. Additionally, we will visualize the behavior of these complexes within the cellular context using light-microscopy and cryo-electron tomography.


We are looking for outstanding scientists who have a strong background in biophysics, biochemistry or neuroscience, and are highly motivated to learn single-particle cryo- EM. Prior experience with single-particle cryo-EM or X-ray crystallography is considered an advantage, but is not essential.


If you’re interested in joining our lab, please send your CV with a brief description of your current research, as well as 2-3 contacts for references, to awf2130@columbia.edu before the 18th of September, 2017.


Link: https://jobs.sciencecareers.org/job/462922/postdoctoral-research-scientist/
Employer: Columbia University
Location: New York, NY
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: September 13th, 2017
Columbia UniversityNew York, NYPhDNDGSep 13, 2017
Postdoctoral Fellow, Hu Lab

Postdoctoral Fellow, Hu Lab

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Description:

A postdoctoral position is available at Cornell University to study lysosomal dysfunction and neurodegeneration in ALS and FTLD. Highly motivated individuals with a strong background in cell biology or mouse genetics and an interest in neurodegenerative diseases are encouraged to apply. Please visit http://hu.wicmb.cornell.edu/ for more details and send your CV and 3 letters of references.


Link: http://hu.wicmb.cornell.edu
Employer: Cornell University
Location: Ithaca, NY
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: September 12th, 2017
Cornell UniversityIthaca, NYPhDALS, FTDSep 12, 2017
Assistant Professor, Mechanisms of Neurological Disease

Assistant Professor, Mechanisms of Neurological Disease

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Description:

The Department of Cell Biology at Emory University School of Medicine seeks outstanding applicants to fill a tenure-path faculty position at the Assistant Professor level in the areas of Neurological Disease, including Neurodevelopmental Disorders or Neurodegeneration.


Applications will be considered in a rolling review and should consist of a cover letter, curriculum vitae, statement of research accomplishments and future goals (maximum limit 2 pages), a brief statement of teaching philosophy and interests, and the names and contact information for three references. Final deadline for applications is December 1, 2017, Applications received after this date may not be considered.


Additional questions should be emailed under the subject header “Cell Biology Faculty Search” to Ms. Luzene Hill (caroline.luzene.hill@emory.edu).


Link: http://emory.jobs/atlanta-ga/assistant-professor-position-in-mechanisms-of-neurological-disease/EFDB9955EF6A4A9597EC0C798CA1E344/job/
Employer: Emory University
Location: Atlanta, Georgia
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: September 9th, 2017
Emory UniversityAtlanta, GeorgiaPhDNDGSep 09, 2017
Postdoctoral Fellow, Centre for Systems Neurobiology

Postdoctoral Fellow, Centre for Systems Neurobiology

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Description:

Linköping University is one of Sweden’s six large universities, currently enrolling 27,000 students. The Centre for Systems Neurobiology involves some 50 independent research groups, from the Faculty of Medicine and the Faculty of Science and Engineering, as well as the University Hospital.


The Centre for Systems Neurobiology is now seeking Postdoctoral Fellows (2+2 years) within several neuroscience research areas: Addiction, Animal Behavior, Electrophysiology and Circuits, Neuroimaging, Neurodegeneration, Neuroendocrinology, Neurodevelopment, Pain, Psychiatry, and Sensory Systems. Applications will be reviewed continuously. For full consideration please apply as soon as possible.


For more details regarding the Centre, the different research labs involved in the programme, and to submit a letter-of-intent please go to: https://liu.se/en/research/center-for-systems-neurobiology .


Link: http://www.nature.com/naturejobs/science/jobs/623879-postdoctoral-fellows
Employer: Linköping University
Location: Linköping, Sweden
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: September 8th, 2017
Applications close: October 27th, 2017
Linköping UniversityLinköping, SwedenPhDNDGSep 08, 2017
Postdoctoral Fellow, Guo Lab

Postdoctoral Fellow, Guo Lab

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Description:

Postdoctoral positions are available in Dr. Junjie Guo’s lab in the Department of Neuroscience at Yale School of Medicine. The Guo lab studies questions at the intersection between RNA biology and neuroscience. Currently, we are interested in the roles of mRNA and noncoding RNA structures in neurodevelopment and neurodegenerative diseases, taking a combination of computational, biochemical, genetic, and genomic approaches. Our lab is situated within the dynamic and collaborative RNA biology and neuroscience communities at Yale that includes the Yale Center for RNA Science and Medicine, the Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR), and the Kavli Institute for Neuroscience at Yale.


Start date is flexible. Candidates should have received a doctoral degree no more than 2 years before the start date. Researchers with strong interest in RNA biology and neuroscience, regardless of their training background, are welcome to apply. Expertise in any of the following areas is desirable though not required:


*Mouse/fly genetics

*Stem cell biology

*Experimental models of neurodevelopment or neurodegeneration

*High-throughput sequencing

*Advanced imaging techniques

*For more information, please visit www.guo-lab.com or contact by email.


Please let us know if you will attend the Society for Neuroscience meeting.


Please email your application to junjie.guo@yale.edu, including:


*A cover letter describing your past training, research interests and career goals

*A detailed CV

*Contact information of referees


Link: http://neurojobs.sfn.org/jobs/10253064/postdoc-in-neuronal-rna-biology
Employer: Yale University
Location: New Haven, CT
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: September 8th, 2017
Yale UniversityNew Haven, CTPhDNDGSep 08, 2017
Assistant or Associate Clinical Professor

Assistant or Associate Clinical Professor

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Description:

The candidate should have areas of specialty interest that would mesh well with existing priorities that include cerebrovascular diseases, neurodegenerative diseases, movement disorders, or epilepsy, but candidates with expertise in other areas will also be considered.  The ideal candidate will have finished a residency plus a Neurology fellowship. The successful candidate will receive start up funding, dedicated research time to build a world-class research program and have a strong interest in an academic career. This is a tenure track position.


Link: https://www.linkedin.com/jobs/view/440619079/
Employer: Stony Brook University
Location: Stony Brook, NY
Sector: Academia
Degree required: MD/PhD
Conditions: NDG
Job posted: September 7th, 2017
Stony Brook UniversityStony Brook, NYMD/PhDNDGSep 07, 2017
Graduate Studentship, Kadener Lab

Graduate Studentship, Kadener Lab

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Description:

We are looking for a highly motivated student to investigate the contribution and role of circular RNAs (circRNAs) in the development of neurodegenerative diseases. The student will join the Kadener lab in Jerusalem, a multidisciplinary team studying the role of circRNAs in physiology and disease in Drosophila. The position is part of circTrain (https://circtrain.eu/) an EU-funded International Training Network (ITN) that focuses on different aspects of circRNA biology.


Our studies range from mechanistic biochemical and molecular characterization to neurobiology and behavioral assessment, including genomic, computational and system- level approaches.

Previous experience in molecular biology, Drosophila genetics or neurobiology is advisable but not required. Relevant publications from our lab in the field include: Pamudurti et al. Mol. Cell 2017; Rybak-Wolf et al. Mol Cell 2015; Ashwall-Fluss et al. Mol. Cell 2014


The position is available immediately and for 3 years and for performing the project #11 described in https://circrtrain.eu/?page_id=82


If interested, please email skadener@gmail.com with a cover letter and CV.


Link: http://www.nature.com/naturejobs/science/jobs/623667-one-phd-position-to-study-circrnas-and-neurodegeneration-in-the-context-of-a-marie-curie-itn-network-at-the-hebrew-university
Employer: Hebrew University
Location: Jerusalem, IL
Sector: Academia
Degree required: BS
Conditions: NDG
Job posted: September 7th, 2017
Hebrew UniversityJerusalem, ILBSNDGSep 07, 2017
Assistant Professor, Neurobiology

Assistant Professor, Neurobiology

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Description:

Applications are invited for a position at the level of tenure-track Assistant Professor. The Department of Neurobiology and Behavior is ranked as one of the top neuroscience departments in the country and engages in interdisciplinary approaches to the study of neurobiology. The Institute for Memory Impairments and Neurological Disorders is home to one of 31 Alzheimer’s Disease Research Centers funded by the National Institutes of Health. We seek outstanding candidates whose research addresses the molecular neuropathology of Alzheimer’s disease and other neurodegenerative disorders. Preference will be given to applicants whose research integrates cutting edge neuroscientific techniques using human and animal tissue.


Applicants should hold a Ph.D., M.D., or equivalent degree, seek to establish a vigorous and highly competitive research program, and to contribute to teaching at both the graduate and undergraduate levels.


Please submit by October 24th, 2017, curriculum vitae, a description of research and teaching interests, and the names and addresses of three potential referees. A separate statement that addresses past and/or potential contributions to diversity, equity and inclusion should also be included in the application materials.


For application instructions, please go to the Department of Neurobiology and Behavior Assistant Professor section at https://recruit.ap.uci.edu/apply/JPF04238.


Link: https://recruit.ap.uci.edu/apply/JPF04238
Employer: University of California
Location: Irvine, CA
Sector: Academia
Degree required: PhD or MD
Conditions: NDG
Job posted: September 6th, 2017
University of CaliforniaIrvine, CAPhD or MDNDGSep 06, 2017
Assistant Professor, Biological Chemistry and Pharmacology

Assistant Professor, Biological Chemistry and Pharmacology

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Description:

The Department of Biological Chemistry and Pharmacology, in the College of Medicine at The Ohio State University, invites applications from investigators using zebrafish as a model organism for a tenure-track faculty position at the rank of Assistant Professor. The successful candidate will join a vibrant and cohesive zebrafish community at The Ohio State University. The department has complementing strengths in motor neuron disorders, neuromuscular biology, RNA biology and epigenetics. There is also a college-wide program to enhance research in neurodegenerative diseases. Research programs that are in neurodegeneration or complement department strengths are particularly encouraged.


Apply to Academic Jobs Online at: http://academicjobsonline.org. Complete applications include a cover letter, curriculum vitae, and a statement of research and teaching interests, and three letters of reference. Applications will be accepted until the position is filled, however those received by November 15, 2017 will receive priority consideration. Inquiries may be directed to Jessica Berner at jessica.berner@osumc.edu.


Link: https://academicjobsonline.org/ajo/jobs/9651
Employer: Ohio State University
Location: Columbus, OH
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: September 5th, 2017
Ohio State UniversityColumbus, OHPhDNDGSep 05, 2017
Assistant Professor, Neurosciences

Assistant Professor, Neurosciences

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Description:

The position is part of a strategic plan designed to further strengthen and expand these areas of excellence, as well as to enhance our interactions within the interdisciplinary program in Molecular, Cellular and Integrative Neurosciences. The research program of strong candidates should complement our current strengths with broad consideration given to the research tools and systems being used.


Responsibilities: The successful hire is expected to develop or maintain an internationally recognized externally-funded research program with a neurobiology focus, participate in undergraduate and graduate education, and to provide service through Departmental, College, and University committees, as well as external review panels. The position requires a firm commitment to undergraduate and graduate education.


Applicants should upload by October 15, 2017 a cover letter, curriculum vitae, statement of research accomplishments and future plans, a statement of teaching interests and philosophy, and the name and contact information for 3 individuals qualified to assess the candidates’ ability to fulfill the responsibilities of the position. Letters of recommendation will be requested via email from referees upon submission of an application and must be submitted on-line. Letters must be received by October 22, 2017 for full consideration. For further information regarding this position, consult the Department of Biochemistry and Molecular Biology website (http://www.bmb.colostate.edu/) or email: Kristen.DeQuasie@colostate.edu.


Link: https://jobs.colostate.edu/postings/49432
Employer: Colorado State University
Location: Fort Collins, CO
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: September 5th, 2017
Applications close: October 15th, 2017
Colorado State UniversityFort Collins, COPhDNDGSep 05, 2017
Postdoctoral Fellow, Buchan Lab

Postdoctoral Fellow, Buchan Lab

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Description:

A position is available in the Buchan lab to study cytoplasmic mRNA biology. We are particularly interested in the assembly, disassembly and function of stress granules and P-bodies, which are cytoplasmic mRNA-protein (mRNP) assemblies that are implicated in regulation of mRNA translation, storage and decay. Recent evidence also suggests important roles for these mRNP bodies in viral defense, cancer and neurodegenerative diseases. A related focus is on the role of vesicular trafficking pathways in mediating clearance of P-bodies, stress granules and aggregates of proteins implicated in neurodegenerative disease such as Amyotrophic Lateral Sclerosis (ALS).


To apply, please submit an online application to job posting P20426 at www.uacareers.com, Please include a brief cover-letter stating your interest in the position and career goals, a CV, and the names and contact information for three references within your application. Review of applications will begin on September 22, 2017 and continue until the position is filled.


Link: https://jobs.sciencecareers.org/job/461852/postdoctoral-research-associate/
Employer: University of Arizona
Location: Tucson, AZ
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: September 5th, 2017
University of ArizonaTucson, AZPhDALSSep 05, 2017
Postdoctoral Fellow, Fraenkel Lab

Postdoctoral Fellow, Fraenkel Lab

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Description:

Are you an expert in neurodegeneration, with a passion for research that will have an impact on curing disease? We seek a talented post-doc to participate in an unprecedented study of the neurodegenerative disease ALS. Working with researchers at clinical and academic institutions across the United States, we are gathering data on approximately 1,000 ALS patients and controls. Induced pluripotent stem cell (iPSC) lines are being derived from each individual and these are being used to generate motor neurons for a wide range of omic studies. Our collaboration seeks to identify different subtypes of the disease, identify correlations between molecular pathways and clinical symptoms and propose therapeutic strategies.


The successful applicant will be responsible for supervising generation of epigenomic data from these patient-derived iPSC lines. She or he will work closely with our collaborators to coordinate the study. In addition, the individual will work closely with our in-house computational biology team, which is integrating omic and clinical data. The successful applicant will take a leading role in deriving hypotheses from the computational analyses, and will design and carry-out follow up experiments, using the iPSC lines and post-mortem tissue.


Previous experience with epigenetic methods and knowledge of neurobiology are essential, as are excellent organizational and communications skills.


Link: http://neurojobs.sfn.org/jobs/10233130/postdoctoral-position-using-systems-biology-to-study-amyotrophic-lateral-sclerosis
Employer: MIT
Location: Cambridge, MA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: September 1st, 2017
MITCambridge, MAPhDALSSep 01, 2017
Research Scientist, ALS

Research Scientist, ALS

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Description:

Under general direction of the Principal Investigator (PI), leadership investigators, and project manager, the incumbent will undertake project activities under a CIRM award developing an embryonic stem cell-based therapy to treat Amyotrophic Lateral Sclerosis (ALS), making innovative and significant independent contributions pertaining to achievement of project milestones.


The incumbent must coordinate specific project activities and individuals across multiple functional areas and organizations, including management of routine cell culture, cell biology and molecular techniques, as well as, development and qualification of new clinically translatable analytical methods for characterizing identity and functional activity of pluripotent stem cells and neural lineage cells.


The incumbent will also perform data analysis on mRNA sequencing data and build a database of sequenced cells to support in vivo and in vitro characterization activities and identify potential markers of safety, efficacy and/or disease progression. Additional responsibilities include independent and collaborative organization, outline, evaluation and preparation of scientific data, results, methods, and conclusions in formal and informal formats including presentations, research manuscripts, funding initiatives, and regulatory submissions; and other tasks as required by project investigators.


Link: https://main.hercjobs.org/jobs/10229189
Employer: University of California
Location: San Diego, CA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: August 31st, 2017
University of CaliforniaSan Diego, CAPhDALSAug 31, 2017
Assistant Professor, Neurobiology

Assistant Professor, Neurobiology

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Description:

The Virginia Tech Carilion Research Institute (VTCRI) (http://research.vtc.vt.edu) is recruiting several faculty in cellular and molecular neurobiology at the assistant professor level. The faculty will be recruited into two new centers (http://research.vtc.vt.edu/centers/) within the institute – the Developmental and Translational Neurobiology Center and the Glial Biology in Health, Disease, and Cancer Center. The faculty members will have tenure track appointments in an appropriate department and college at Virginia Tech.


The VTCRI Developmental and Translational Neurobiology Center: Successful applicants should have established or have the potential for establishing an innovative research program that has received or is likely to receive extramural funding. One position is for a neurobiologist studying mechanisms underlying brain development and the other is for a neurobiologist or neuro-immunologist studying aging, neurodegenerative diseases, and/or brain injury. Questions regarding these positions should be directed to Dr. Michael Fox (mafox1@vtc.vt.edu), co-chair of the search committee and director of the Center or to Dr. Michael Friedlander (friedlan@vtc.vt.edu), co-chair of the search committee and executive director of the VTCRI.


The VTCRI Glial Biology in Health, Disease, and Cancer Center: Successful applicants should have established or have the potential for establishing an innovative research program in glial biology that has received or is likely to receive extramural funding. Areas of particular interest include glial-neuronal and glia-vascular interactions, role of glia in brain development, synaptogenesis, myelination and/or the role of glia in disease. Questions regarding these positions should be directed to Dr. Harald Sontheimer (sontheimer@vt.edu), co-chair of the search committee and director of the Center or to Dr. Michael Friedlander (friedlan@vtc.vt.edu), co-chair of the search committee and executive director of the VTCRI.


Applications will be reviewed until the positions are filled. Initial interviews are expected to begin in October, 2017. To apply, please submit your application including curriculum vitae, detailed statement of research accomplishments and interests and teaching/mentoring philosophy at www.jobs.vt.edu, posting #TR0170108 or http://listings.jobs.vt.edu/postings/79399. Have at least three references post their letters of support to the same site.


Link: https://listings.jobs.vt.edu/postings/79399
Employer: Virginia Tech
Location: Blacksburg, VA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: August 30th, 2017
Virginia TechBlacksburg, VAPhDNDGAug 30, 2017
Physician-Scientist (Faculty)

Physician-Scientist (Faculty)

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Description:

Lewis Katz School of Medicine at Temple University

The Center for Translational Medicine (CTM) at the Lewis Katz School of Medicine at Temple University is seeking qualified candidates and candidate nominations for a Tenure Track Faculty Physician-Scientist dedicated to neurodegeneration research. This position will also have clinical responsibilities and a joint appointment in the Department of Neurology.


CTM was established in 2012 and houses twelve (12) independent research labs with stat-of-the-art facilities in a new open-concept research building. The Center currently has multi-disciplinary research interests in gene and stem cell therapy, cardiac and neuronal signaling, heart failure, Alzheimer’s disease and mitochondrial pathobiology with research cores supporting imaging, gene therapy/vectors, bioenergetics, and surgery/physiology. This position will complement and synergize with ongoing basic, translational and clinical research programs in the CTM and across Temple’s Medical campus.


Successful candidates will hold an MD or MD/PhD degree with the ability to obtain a medical license within the commonwealth of Pennsylvania. A focus in basic science or translational research in adult-onset neurodegenerative diseases including Alzheimer’s, Parkinson’s, ALS or Dementia is required, as well as a strong academic record. Academic appointment is available at all levels and competitive packages will be offered based on qualifications. Candidates with current independent funding are preferred.


Interested candidates should submit a current curriculum vita with complete contact information, and letters of interest to the address below. Contributions to diversity are strongly encouraged.


Walter J. Koch, PhD, William Wikoff Smith Endowed Chair in Cardiovascular Medicine, Professor and Chair, Pharmacology, and Professor and Director, Center for Translational Medicine; C/O Debbie Hinnerschitz, DASPR, Physician Recruiter, Lewis Katz School of Medicine at Temple University, 3420 N. Broad Street, MRB 101, Philadelphia, PA, 19140


Email: debbie.hinnerschitz@tuhs.temple.edu.

Phone: 215-707-4419

Fax: 215-707-9452


Link: https://www.nature.com/naturejobs/science/jobs/622781-tenure-track-faculty-physician-scientist-for-translational-medical-research-in-neurodegeneration
Employer: Temple University
Location: Philadelphia, PA
Sector: Academia
Degree required: MD or MD/PhD
Conditions: ALS
Job posted: August 28th, 2017
Temple UniversityPhiladelphia, PAMD or MD/PhDALSAug 28, 2017

Industry

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Sr. Director, Clinical Research, Rare and Neurological Diseases

Sr. Director, Clinical Research, Rare and Neurological Diseases

(Click title to open job details in a new window.)
Description:

The Rare Disease Research Unit is looking for a talented senior physician scientist to join our team developing transformational new treatments in rare Neuromuscular, Neurodevelopmental and Neurodegenerative diseases using AAV gene therapy. This individual will focus on the challenging translational, clinical and regulatory problems presented by gene therapy in rare (often) pediatric indications, including natural history studies, novel endpoint development and clinical trial design. The candidate will be accountable for the delivery of translational and clinical development plans for AAV gene therapy programs in multiple rare neurological indications, and will be skilled in early clinical program design and conduct from pre-clinical stages to POC. Similar activities will be required for programs exploiting other treatment modalities. Experience and proven collaborative skills with basic and clinical scientists, investigators, regulators and safety functions are essential.


*Accountable for the development of translational and clinical development plans in rare Neuromuscular, Neurodevelopmental and *Neurodegenerative diseases using AAV gene therapy and other modalities for RDRU projects

*Lead interactions with colleagues in Global Product Development and Pfizer Innovative Health with regard to clinical development planning and product concept development for AAV gene therapies and other modalities.

*Partner with functions in Early Clinical Development as needed to ensure that biomarker and quantitative development plans are enabled in all relevant Rare Neuro programs to help determine early signs of efficacy and proof of concept, patient stratification, etc.

*Serve as a clinical champion for early development Rare Neuro programs in AAV gene therapy and other modalities

*Help to build, develop, and lead motivated and engaged matrix teams

*Provide oversight to clinical teams, including:

*Lead preparation of clinical sections of all relevant regulatory filings (IND, Orphan designation, Fast track and breakthrough designations – including NDA/BLA when required).

*Oversee management of studies and serve as expert on clinical and medical issues, including medical monitoring where necessary

*Oversee review of study data, including safety monitoring and SAE reporting

*Oversee writing of final study reports and preparation of documents for submission

*Establish and support relationships with external experts, consultants, key opinion leaders, to ensure implementation of latest clinical thinking and guidelines into clinical development plans and study designs

*Serve as medical and technical resource for clinical issues raised by internal and external collaborators, investigators, consultants and contractors

*Mentor or supervise other clinicians to expand drug development understanding and provide development opportunities

*Foster a transparent environment that encourages strong partnerships and mutual trust between teams, sub-teams, and therapeutic areas.

*Represent the company at scientific meetings and presentations, interactions with rare disease foundations, as well as other public relations opportunities

*Assist in the development of publications, abstracts, and presentations

*Support business development activities as needed, including due diligence activities.

*Maintain up-to-date knowledge of scientific and clinical published literature in relevant therapeutic areas including the key clinical development issues.


Link: https://pfizer.wd1.myworkdayjobs.com/en-US/PfizerCareers/job/USA---MA---Cambridge-Kendall-Sq-610-Main/SrDirector-ClinResClinicMD_1605538?source=Linkedin
Employer: Pfizer
Location: Cambridge, MA
Sector: Industry
Degree required: MD or MD/PhD
Conditions: NDG
Job posted: October 13th, 2017
PfizerCambridge, MAMD or MD/PhDNDGOct 13, 2017
NEW! Research Scientist, Protein Sciences

Research Scientist, Protein Sciences

(Click title to open job details in a new window.)
Description:

We are seeking a Scientist with expertise in protein expression, purification and analytical characterization to contribute to our drug discovery efforts.


Responsibilities:


*Implement a number of expression systems (including mammalian, insect and bacterial) to support small to large scale production of proteins and antibodies.

*Perform small-scale expression and purification screening and optimization for both secreted and cytosolic proteins.

*Develop cell lines expressing specific protein(s).

*Characterize expressed/purified proteins through in vitro analytical techniques including mass spectrometry.


Requirements:


*PhD in Biology, Biochemistry or a related field with 2+ years of relevant experience with antibody and protein expression, purification and characterization.

*Hands-on mammalian/baculoviral expression system experience is required.

*Proficiency with scaling cellular expression systems from 96-well to liter formats.

*Experience with creating stable cell lines.

*Ability to carry out mass spectrometry on proteins/peptides.

*Ability to work independently with minimal supervision while meeting timelines.

*Highly self-motivated with a strong sense of responsibility and a collaborative spirit.


Link: https://www.denalitherapeutics.com/careers/?gh_jid=252383
Employer: Denali Therapeutics
Location: San Francisco, CA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: October 10th, 2017
Denali TherapeuticsSan Francisco, CAPhDNDGOct 10, 2017
NEW! Research Scientist

Research Scientist

(Click title to open job details in a new window.)
Description:

We are looking for an experienced research scientist to join the Neuroscience department. The scientist will assume a hands-on role in a team responsible for an early drug discovery project for a neurodegenerative disorder. The scientist will conceive, conduct, and analyze experiments to identify and validate novel targets and low molecular weight modulators. In vitro and ex vivo models, including hPSC-derived neuronal platforms, and other molecular and cell biology techniques, will be heavily utilized within projects. Excellent communication and teamwork will be critical.


Minimum requirements The candidate will have a B.S. or M.S. degree or equivalent in biochemistry, neuroscience, cell biology, or a similar discipline with at least three years of industrial or academic research experience. The candidate will ideally have familiarity with iPS / ES cell research and cell-based assay development including phenotypic profiling by high-content imaging. The candidate must be highly collaborative, self-motivated, team-oriented, and have excellent communication and computer skills. Deep expertise in some of the techniques listed below is required, with an expectation that the candidate will develop any new technical skill as needed to answer the biological question at hand.


•Pluripotent stem cell culture and differentiation.

•Immunofluorescence techniques, including modern high-content imaging and computational image analysis to extract phenotypic data from complex cultures.

•High throughput cell-based screening.

•Molecular biology, including cell line engineering by CRISPR/CAS9, introduction of reagents into neurons by viral transduction or transfection and biochemical assay development.


Link: https://sjobs.brassring.com/TGWEbHost/jobdetails.aspx?partnerid=13617&siteid=5268&Areq=224554BR&codes=13335
Employer: Novartis
Location: Cambridge, MA
Sector: Industry
Degree required:
Conditions: NDG
Job posted: October 9th, 2017
NovartisCambridge, MANDGOct 09, 2017
Research Scientist

Research Scientist

(Click title to open job details in a new window.)
Description:

We are currently seeking a highly motivated, experienced scientist to join the stem cell group in the Neuroscience department to aid in target discovery and validation in the areas of psychiatry and neurodegeneration.


Posting Title: Neuroscience Pluripotent Stem Cell Investigator/Scientist


Responsibilities:

•Develop hESC and hiPSC models and relevant phenotypic cell-based and biochemical assays to study neurodevelopmental, psychiatric, and neurodegenerative disorders

•Employ CRISPR technology to generate reporter cell lines and perform KO studies in PSC-derived neurons

•Analyze, interpret, and communicate scientific data

.

Minimum requirements The ideal candidate would have:

•A Ph.D. with 0-4 years of postdoctoral research experience or M.S. with 10+ years of research experience, a record of significant achievements in research, creativity, excellent communication and leadership skills, and the ability to work in a multidisciplinary, team-oriented environment

•A neuroscience background, with expertise in differentiating neuronal lineages from human pluripotent stem cells

•Experience in developing biochemical and cell-based functional assays, including protein-protein/protein-RNA interactions, high-content, calcium, and live-cell imaging

•Proficiency in cellular and molecular biology techniques, including qPCR, cloning, western blotting, immunofluorescence, and FACS

•Experience in genome engineering technologies and CRISPR or shRNA screening is a plus

•Experience in genomics, including analyzing RNA-seq and other omics data, is a plus

•The ability to work productively in a fast-paced environment that requires a high level of communication, collaboration, and organization


Link: https://sjobs.brassring.com/TGWEbHost/jobdetails.aspx?partnerid=13617&siteid=5268&Areq=224438BR&codes=13335
Employer: Novartis
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: October 7th, 2017
NovartisCambridge, MAPhDNDGOct 07, 2017
Senior Scientist, Neuroscience

Senior Scientist, Neuroscience

(Click title to open job details in a new window.)
Description:

As a Senior Scientist in Merck’s Neuroscience Department you will engage in exciting drug discovery research targeting the treatment of Neurodegenerative diseases. An expert in cellular and molecular biology, you will have the opportunity to work as part of a high profile team applying cutting edge cell biology techniques to identify, validate and progress innovative novel drug targets. You will design, implement and run biochemical and cell based assays to support our drug discovery efforts.


Responsibilities include but are not limited to:


– Build novel cellular models utilizing cell lines, primary neuronal cultures as well human iPSC-derived neurons that probe various biochemical and functional endpoints

– Use molecular, genetic, imaging and/or biochemical techniques to investigate relevant disease mechanisms in vitro and in vivo models

– Maintain awareness and implement technology that would enable scientific problem solving and/or improve efficiency

– Analyze, interpret and present data at group and departmental meetings and write internal documents on technical and scientific findings


Link: https://jobs.sciencecareers.org/job/463689/senior-scientist-biology-west-point-neuroscience-job/
Employer: Merck
Location: West Point, PA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: September 21st, 2017
MerckWest Point, PABS or MSNDGSep 21, 2017
Director, Neuroscience Electrophysiology

Director, Neuroscience Electrophysiology

(Click title to open job details in a new window.)
Description:

Job Responsibilities Include:


*Conduct and direct staff conducting electrophysiology based experiments to support drug discovery programs


*Perform and enable pharmacological, mechanistic and/or phenotypic in vitro electrophysiological experiments in recombinant and native tissues (cells and slices). Hands-on experience of in vivo electrophysiology and high throughout ion channel biology experience and/or leadership of such skillsets would be a plus.


*Manage a group of scientists in their daily activities to encourage focused research linked with critical path activities as well as encourage innovation


*Provide direction to help resolve technical challenges and deliver results in a timely and integrated fashion


*Report and communicate scientific ideas and results in English (both verbal and written) to senior management as needed

Work as an inspiring and influential leader to promote excellence in scientific advancement


*Liaise with other disciplines to ensure an integrated approach that fits the needs of the portfolio


Link: https://careers.peopleclick.com/careerscp/client_gsk/external1931/gateway.do?functionName=viewFromLink&jobPostId=351999&localeCode=en-us&eresc=LinkedIn&source=LinkedIn&sourceType=PREMIUM_POST_SITE
Employer: GSK
Location: Collegeville, PA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: September 18th, 2017
GSKCollegeville, PAPhDNDGSep 18, 2017
Director or Senior Director, Gene Transfer Technologies

Director or Senior Director, Gene Transfer Technologies

(Click title to open job details in a new window.)
Description:

The Director/Senior Director is a recognized expert in the science and applications of gene transfer and gene therapy. The incumbent will lead the Gene Transfer Technologies research group whose mission is to:


*Complete the design, assembly and research grade production of AAV vectors to be used in early exploratory programs;

*Characterize and expand the NAV platform of AAV vectors;

*Explore solutions for AAV-based in-vivo gene editing and for control of transgene expression;

*Evaluate other viral and non-viral gene transfer systems.


PRIMARY RESPONSIBILITIES


*Leads scientists and/or research associates to build an efficient and state of the art assembly line providing AAV vectors for relevant REGENXBIO projects (internal or in collaboration with outside organizations).

*As part of the R&D management team, ensure optimal integration of the Gene Transfer Technologies group with other function within R&D or outside (Clinical, Technical Operations, Regulatory, Business Development).

*Hires and manages staff, provides training as needed, and ensures adherence to company policies and quality requirements.

*Serves as an in-house consultant.

*Synthesizes multiple data sources and draws general, non-obvious conclusions.

*Defines complex problems, develops approaches and develops experiments with sound judgment.

*May independently represent the Company to outside organizations.

*Interfaces with various departments, customers and partners.

*Puts work practices in context with larger team and participates in the implementation of change when required.

*Plans and coordinates activities with other team members.

*May assist with designing and implementing organizational processes, budgetary and capital equipment requirements, and identifies needs for additional resources.

*Performs additional tasks or assist with special projects as assigned or needed


Link: https://www.linkedin.com/jobs/view/433981404/
Employer: REGENXBIO
Location: Rockville, MD
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: September 17th, 2017
REGENXBIORockville, MDPhDNDGSep 17, 2017
CNS Pre-Clinical Research Lead

CNS Pre-Clinical Research Lead

(Click title to open job details in a new window.)
Description:

The Neuroscience Lead (or CNS) will manage the CNS functional group within the Discovery Research group under Translational Research. He/she will be responsible for:


· Providing leadership within a group of scientists/research associates, to develop pre-clinical programs from early discovery to the clinic.


· Initiate and oversee joint programs with academic collaborators.


· Establishing project timelines and ensuring work is completed according to schedule.


· Training and developing staff at varying levels of experience.


The Neuroscience Lead (or CNS) will manage the CNS functional group within the Discovery Research group under Translational Research. He/she will be responsible for:


· Providing leadership within a group of scientists/research associates, to develop pre-clinical programs from early discovery to the clinic.


· Initiate and oversee joint programs with academic collaborators.


· Establishing project timelines and ensuring work is completed according to schedule.


· Training and developing staff at varying levels of experience.


The CNS Preclinicnal Lead position requires extensive translational experience with CNS gene therapies, including;


· In-depth knowledge of neurodegenerative disorders.


· Experience with delivery techniques targeting the central nervous system such as intracranial injecions and have substantial experience with studies in laboratory animals.


· Familiarity with target validation and lead identification/optimization, using a combination of molecular, cellular and in vitro/in vivo techniques for CNS gene therapy programs.


· Some familiarity with AAV, as well as some knowledge of clinical trial design and regulatory strategy, is preferred.


Link: https://www.linkedin.com/jobs/view/412216788/
Employer: Spark Therapeutics
Location: Philadelphia, PA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: September 15th, 2017
Spark TherapeuticsPhiladelphia, PAPhDNDGSep 15, 2017
Scientist, Protein Sciences

Scientist, Protein Sciences

(Click title to open job details in a new window.)
Description:

Denali Therapeutics is seeking a Scientist with expertise in antibody and protein expression and purification to contribute to our drug discovery efforts.


Responsibilities:


*Implement various expression systems, particularly mammalian expression systems, to support small to large scale production of proteins and antibodies.

*Perform small-scale expression and purification screening and optimization for both secreted and cytosolic proteins.

*Assist with medium to large scale protein expression.

*Manage cell culture and maintain cell lines for protein production.

*Contribute, as needed, to the molecular biology and functional characterization of proteins and antibodies.


Link: https://www.denalitherapeutics.com/careers/?gh_jid=252383
Employer: Denali Therapeutics
Location: San Francisco, CA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: September 15th, 2017
Denali TherapeuticsSan Francisco, CAPhDNDGSep 15, 2017
Scientist or Senior Scientist, Discovery Biology

Scientist or Senior Scientist, Discovery Biology

(Click title to open job details in a new window.)
Description:

Prevail Therapeutics, Inc is a new biotech company based in New York City. Prevail is developing novel treatments for neurodegenerative disorders using gene and protein therapeutic modalities. Prevail is backed by a top-tier healthcare focused investment firm.


Scientists, Discovery Biology will be responsible for leading our efforts to identify and advance the development of novel targets for neurodegenerative disorders. We are looking for enthusiastic, self-motivated, hands-on individuals with excellent interpersonal skills who are comfortable working in an open environment spanning multiple functions. As an early hire at a new company, you will have exposure to senior management, to all activities at Prevail, and you will be influential in championing and developing Prevail’s culture.


Our employees are expected to function with a high degree of independence in a fast-paced start-up laboratory while also working collaboratively within a multidisciplinary team that is dedicated to the development of new therapies for neurodegenerative diseases.


Link: https://www.nature.com/naturejobs/science/jobs/624383-scientists-various-levels-discovery-biology
Employer: Prevail Therapeutics
Location: New York, NY
Sector: Industry
Degree required: PhD or MD or MD/PhD
Conditions: NDG
Job posted: September 14th, 2017
Prevail TherapeuticsNew York, NYPhD or MD or MD/PhDNDGSep 14, 2017
Scientist I, ALS

Scientist I, ALS

(Click title to open job details in a new window.)
Description:

Neurology Research at Biogen seeks a highly motivated and experienced associate scientist to join the new initiative on ALS (amyotrophic lateral sclerosis). The Neurology department is responsible for discovery research on pathogenic mechanisms of neurodegenerative disorders and translating these findings into novel strategies for therapeutic intervention. The successful candidate will execute in vivo experiments to support the validation of novel drug targets and the development of small- and large-molecule drugs for the treatment of ALS. A major component of this work will be the assessment of drug candidates in a multiple rodent models, using a wide variety of morphological and functional endpoints, working closely with members of the ALS team as well as multiple internal and external collaborators. You will work in a fast paced, highly collaborative team environment at an exciting period for ALS research.


Link: https://jobs.biogen.com/job/Cambridge-Scientist-I%2C-ALS%2C-Neurodegeneration-and-Repair-MA-02138/418016000/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: ALS
Job posted: September 10th, 2017
BiogenCambridge, MAPhDALSSep 10, 2017
Associate Scientist

Associate Scientist

(Click title to open job details in a new window.)
Description:

Yumanity is seeking a talented and versatile BS/MS scientist to join our interdisciplinary team to help advance novel drug discovery programs for neurodegenerative diseases. This position will be laboratory based, and requires strong experimental skills with background in cell and molecular biology and experience in quantitative assay development. The successful candidate must be highly flexible and team-oriented. The position will report to a Principal Scientist in the Mammalian Assay Development group, and will interact across all of Yumanity’s core platforms, including yeast phenotypic screening, target identification, stem cells and chemistry.


Link: http://www.yumanity.com/careers/
Employer: Yumanity
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: September 8th, 2017
YumanityCambridge, MABS or MSNDGSep 08, 2017
Research Scientist

Research Scientist

(Click title to open job details in a new window.)
Description:

We are seeking highly motivated individuals with BS/MS degrees to join a dynamic research group in the Neurosciences Division at Novartis Institutes for Biomedical Research in Cambridge, MA. The individual will conduct hands-on research directed towards understanding the molecular mechanisms underlying neurodegenerative disorders, and identify and evaluate small molecule compounds or biologics that target key pathogenic events in these diseases. Proficiency in the use of current molecular biology and biochemical techniques is expected. Extensive experience in mammalian cell culture, viral transduction techniques as well as gene knockdown technology and stable cell line generation are preferred. Candidates should have strong data analysis and communication skills. In addition to the above expertise candidates are expected to gain new skills based on evolving project needs and demands.


Link: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?partnerid=13617&siteid=5260&alcon&jobId=2506843&JobReqLang=1&codes=LIIN-W&Codes=W-LINKEDIN
Employer: Novartis
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: September 8th, 2017
NovartisCambridge, MABS or MSNDGSep 08, 2017
Scientist or Senior Scientist

Scientist or Senior Scientist

(Click title to open job details in a new window.)
Description:

Verge Genomics is seeking a Scientist or Senior Scientist to join the Neurobiology Research and Drug Discovery team. This candidate will bring significant academic and preferably pharmaceutical industry experience to conduct in vivo and in vitro research in our SF Bay Area laboratories and join team meetings at Verge Genomics headquarters in SF. The candidate will be responsible for the design and execution of target validation and evaluation of novel drug candidates for neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Parkinson’s disease. The candidate will conduct in vivo studies in mice, including injections of gene modifying agents and drug candidates to neonatal and adult rodents using intracranial, oral, or intravenous administration routes. Experience with stereotaxic surgery, gene therapy (AAV9 or ASO), behavioral observations, gait analysis, rotarod and grip strength, and genotyping are a plus. The candidate will have extensive knowledge of CNS disease mechanisms, existing therapies, and experimental therapeutic approaches. The candidate will also culture motor neurons differentiated from induced pluripotent human stem cells and design and develop cellular assays to identify genes and compounds for treating neurodegenerative diseases including ALS and PD. The candidate will have extensive experience and leadership skills with sterile in vitro methods, including harvesting, storing, growing, and expanding neuronal cultures, formulating and adding compounds and molecular probes, measuring cells numbers and properties with immunohistochemical markers, and evaluating gene transfection. A keen ability to identify efficient solutions to laboratory problems and expertise with statistical analysis are essential. This position reports to the Director of Drug Discovery.


Link: https://www.linkedin.com/jobs/view/443045718/
Employer: Verge Genomics
Location: San Francisco, CA
Sector: Industry
Degree required: PhD
Conditions: ALS
Job posted: September 7th, 2017
Verge GenomicsSan Francisco, CAPhDALSSep 07, 2017
Associate Scientist III, ALS

Associate Scientist III, ALS

(Click title to open job details in a new window.)
Description:

The Department of Neurology Research is seeking a highly talented and enthusiastic associate to join an in vitro / in vivo target discovery and validation effort in Amyotrophic Lateral Sclerosis (ALS) aimed at bringing new targets and therapeutic strategies from discovery to development. The successful candidate will be expected to support efforts to develop and validate new in vitro ALS models for candidate identification and validate findings in primary mouse tissue.

The successful candidate must have a MS in the Biological Sciences, and will be charged with developing high content assays that will be used to validate genes and pathways identified in genetic screens that affect neurodegeneration.


The ideal candidate will have previous experience using cell based methods to investigate neurodegeneration. Experience with biochemical analytical methods such as gel electrophoresis, Western blot, ELISA-type assays, qRT-PCR, as well as immunohistochemistry and immunofluorescence on cells and tissues is important. The candidate will also need experience using AAV or lenti viral transduction approaches as well as experience with RNAi technologies. It is strongly desirable that the candidate has experience basic mouse handling experience with basic surgical techniques. Very strong communication skills are critical for the position as is the ability to work effectively in a highly collaborative research environment.


Link: https://jobs.biogen.com/job/Cambridge-Associate-Scientist-II%2C-ALS-Target-Validation-Research-MA-02138/400261100/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: MS
Conditions: ALS
Job posted: August 29th, 2017
BiogenCambridge, MAMSALSAug 29, 2017

Non-Profit and Government

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Associate Scientist

Associate Scientist

(Click title to open job details in a new window.)
Description:

The ALS Therapy Development Institute (ALS TDI) has an opening for a full-time Associate Scientist working in the Translational Research group. The Associate Scientist will be part of the team working to develop patient-derived induced pluripotent stem cell (iPSc) collection, as well as the development and implementation of cell-based high content screens for target and drug discovery.


Responsibilities include but are not limited to:


*Isolation and banking of patient-derived primary cells

*Generating and characterizing of iPSc and their differentiated derivatives

*Assisting in the development and characterization of isogenic genome-edited and patient-derived cell-based screening models


Link: https://www.idealist.org/en/job/4ff78fc67b4f4e5cb85abfb28af732b9-associate-scientist-als-tdi-cambridge?
Employer: ALS Therapy Development Institute
Location: Cambridge, MA
Sector: Non-Profit
Degree required: BA or BS
Conditions: ALS
Job posted: October 16th, 2017
Applications close: November 20th, 2017
ALS Therapy Development InstituteCambridge, MABA or BSALSOct 16, 2017
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