Figure 3. Expression of oligodendrocyte-specific cell type markers in F3.Olig2 cells and expression of motor neuron-specific cell type markers in F3.Olig2-Shh cells.
Image credit: Lee, et.al. 2014 under CC BY license

Job Opportunities

To submit any new job opportunities for this list, please email ALSjobs@prize4life.org. List the employer, location, closing date if applicable, and a link to more information. Jobs are removed after 3 months, unless requested otherwise.

This free job bulletin board aims to help scientists identify job opportunities in the field of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Positions described as broadly spanning neurodegenerative diseases (NDG) are noted as ‘NDG‘. The job listing includes research positions at all levels, as well as non-research positions for which a research background at the MS, PhD, or MD level is required.


Click the title of any table column to sort.

Academia

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Clinical Senior Lecturer

Clinical Senior Lecturer

(Click title to open job details in a new window.)
Description:

Kings College London is making a major investment in Dementia and Neurodegeneration research with several new Principal Investigator Posts and Fellowships. We are looking to appoint an exceptional clinical Neuroscientist who shares our ambition to make KCL one of the world’s leading centres for Dementia and Neurodegeneration Research. They will be based in the newly built Maurice Wohl Clinical Neuroscience Institute. The post will be supported by a competitive start-up package and a significant equipment budget.


Applications are welcomed from investigators whose work focuses on exploring fundamental disease mechanisms, preclinical studies and fully translational intervention across all aspects of Dementia and other Neurodegenerative disorders. Collaborative links to biotechnology and pharmaceutical industries are welcome. Ultimately, success will be measured by high impact publication output, success in attracting research funding, contribution to teaching and the scientific strategy of the Department.


The selection process will include a presentation and panel interview, and may include a formal lecture to members of the university.


The deadline for applications is midnight on 30 June 2017.


Interview dates are TBC.


For an informal discussion to find out more about the role please contact Prof Christopher Shaw on +44(0)207 848 0259 or email chris.shaw@kcl.ac.uk


To apply for this role, please visit https://www.hirewire.co.uk/HE/1061247/MS_JobDetails.aspx?JobID=76888 and register to download and submit the specified application form.


Link: https://www.hirewire.co.uk/HE/1061247/MS_JobDetails.aspx?JobID=76888
Employer: King's College London
Location: London, England
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 17th, 2017
Applications close: June 30th, 2017
King's College LondonLondon, EnglandPhDNDGMay 17, 2017
NEW! Senior Lecturer

Senior Lecturer

(Click title to open job details in a new window.)
Description:

Kings College London is making a major investment in Dementia and Neurodegeneration research with several new Principal Investigator Posts and Fellowships. We are looking to appoint an exceptional Neuroscientist who shares our ambition to make KCL one of the world’s leading centres for Dementia and Neurodegeneration Research. They will be based in the newly built Maurice Wohl Clinical Neuroscience Institute. The post will be supported by a competitive start-up package and a significant equipment budget.


Applications are welcomed from Investigators whose work focuses on exploring fundamental disease mechanisms, preclinical studies and fully translational intervention across all aspects of Dementia and other Neurodegenerative disorders. Collaborative links to biotechnology and pharmaceutical industries are welcome. Ultimately, success will be measured by high impact publication output, success in attracting research funding, contribution to teaching and the scientific strategy of the Department.


The selection process will include a presentation and panel interview, and may include a formal lecture to members of the university.


The deadline for applications is 30th June 2017.

Interviews are scheduled T.B.C.


For an informal discussion to find out more about the role please contact Prof Christopher Shaw on +44(0)207 848 0259 or email chris.shaw@kcl.ac.uk


To apply for this role, please visit https://www.hirewire.co.uk/HE/1061247/MS_JobDetails.aspx?JobID=76879 and register to download and submit the specified application form.


Link: https://www.hirewire.co.uk/HE/1061247/MS_JobDetails.aspx?JobID=76879
Employer: King's College London
Location: London, England
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 17th, 2017
Applications close: June 30th, 2017
King's College LondonLondon, EnglandPhDNDGMay 17, 2017
NEW! Assistant Professor, Neuroscience and Cell Biology

Assistant Professor, Neuroscience and Cell Biology

(Click title to open job details in a new window.)
Description:

Specific Job Related Duties


Participate in training investigators in the areas of neurodegenerative disease and otherdisorders of the nervous system


Partner with established biomedical researchers in a highly collaborative biomedical researchcommunity to foster mutual scientific goals


Build translational research programs


Participate in committees which serve the Department, and the University


Preferred Skill/Competency


Ability to collaborate within a team of researchers in a translational and basic science researchresearch setting


Excellent command of the English language both written and spoken


Preferred Work Experience


Ability to collaborate across scientific disciplines


Link: http://utmb.jobs/galveston-tx/assistant-professor-neuroscience-cell-biology/637E2506D7C14A01A2D91B1D6E94C788/job/
Employer: University of Texas
Location: Galveston, TX
Sector: Academia
Degree required: PhD or MD
Conditions: NDG
Job posted: May 16th, 2017
University of TexasGalveston, TXPhD or MDNDGMay 16, 2017
NEW! Clinical Senior Lecturer, Neuropathology

Clinical Senior Lecturer, Neuropathology

(Click title to open job details in a new window.)
Description:

We are looking to appoint a Clinical Senior Lecturer/Reader in Neuropathology to join the Centre for Neuroinflammation and Neurodegeneration (CNN), where they will undertake a programme of research in Neuropathology as well as becoming one of the directors of the UK MS and PD Tissue Bank, and contribute to the clinical neuropathology service at Imperial College Healthcare Trust.


The CNN researches neurodegeneration and neuroinflammation, neuropathological studies, neuroimaging methods, and therapeutic monitoring, as well as clinical translation and trial development for novel therapies.


We are interested in hearing from academics with a track record of high quality publications in Neurodegenerative mechanisms contributing to Multiple Sclerosis and Parkinson’s disease. However we will be pleased to consider those with other interests that impact on Neuropathology.


The level of appointment and supporting package will be determined according to experience and research profile using the following guidelines:


As Clinical Senior Lecturer you will have extensive professional experience and be able to demonstrate a reputation in the area of Neuropathology based on your research. You will be expected to show independence through original research work, and demonstrate your aptitude for teaching.


For appointment as Clinical Reader you will have developed an international reputation based on a track record of research in Neuropathology, and consistently demonstrate the ability to attract research income. You will be an experienced teacher with the potential to develop and deliver educational programmes.


For either level you will have full GMC registration with a licence to practise (or be eligible for registration within six months of interview), have completed your CCT and hold membership of the Royal College of Pathologists. You will have extensive experience of the diagnostic neuropathological service of neoplastic, inflammatory, neurodegenerative and vascular disease, including intraoperative assessment, as well as skill in carrying out muscle and peripheral nerve biopsies.


Imperial College provides an outstanding environment for basic, clinical and translational research, and supports academics through tailored training programmes, with mentoring and comprehensive administrative support. This is a fantastic opportunity for an individual with the ability to develop their original ideas, lead a research group and work to be among the best in the field.Imperial College s happy to discuss the possibility of part-time working subject to operational requirements.


Informal enquiries can be made to Professor Richard Reynolds r.reynolds@imperial.ac.ukOur preferred method of application is online via our website by clicking the apply button.


Please complete and upload an application form as directed quoting reference number HM2017070.If you are unable to apply online, please email f.whyte@imperial.ac.uk to request an application form.Closing Date: Thursday 29th June 2017 (Midnight BST)


Link: https://jobs.bmj.com/job/59232/clinical-senior-lecturer-reader-in-neuropathology/
Employer: Imperial College London
Location: London, England
Sector: Academia
Degree required: Licensed Neuropathologist
Conditions: NDG
Job posted: May 16th, 2017
Applications close: June 29th, 2017
Imperial College LondonLondon, EnglandLicensed NeuropathologistNDGMay 16, 2017
NEW! Postdoctoral Fellow, Neurogenetics

Postdoctoral Fellow, Neurogenetics

(Click title to open job details in a new window.)
Description:

As postdoc you will be working on data from Project MinE (www.projectmine.com). This is unique genomic dataset in the field of Amyotrophic Lateral Sclerosis (ALS), a rapidly progressive, invariably fatal neurological disease that attacks the nerve cells responsible for controlling voluntary muscles, which include epigenetic, whole genome sequencing and clinical data of several thousand of ALS patients and matched controls. We have recently published the first results of this dataset (Van Rheenen et al. Nat Genet. 2016 (PMID: 27455348), and Kenna et al. Nat. Genet. 2016 (PMID: 27455347)). Your focus will be on exploring adding external controls and cases to this dataset while preserving type I error in case-control comparisons, annotating the non-coding genome by integrating our data with other publicly available omics datalayers, including RNAseq, Hi-C and Chip-seq and relating this to case-control status. Another type of genomic variation potentially related to ALS we are interested in, is structural variation. This means you need to have experience in working with raw sequencing data on a large number of samples and be able to apply complex genetic statistics in this context. There is a suitable ICT setup available for you to achieve this. We expect you to be able to use various bioinformatic tools on next-generation sequencing data and combine these to identify possible novel ALS risk genes, and pathological pathways. Also, we would like you to integrate these genetic data with drug databases in order to prioritize potential new drug targets for ALS and repurposing of existing drugs for ALS. This part of the work will be done in collaboration with a biotech company. You will also be expected to participate in writing scientific papers and grant applications, provide methodological advice to other members of the team (bioinformaticians, PhD students, postdocs, technicians), and participate in educating bachelor and master students.


Link: http://www.werkenbijumcutrecht.nl/vacatures/paginas/postdoc-neurogenetics%20(2017-0434).aspx?ccs=1
Employer: UMC Utrecht
Location: Utrecht, The Netherlands
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: May 16th, 2017
UMC UtrechtUtrecht, The NetherlandsPhDALSMay 16, 2017
NEW! Assistant Professor, Genetics

Assistant Professor, Genetics

(Click title to open job details in a new window.)
Description:

The Centre for Integrative Biology of the University of Trento invites candidates active in Genetics to apply for a position at the Assistant Professor level. The position is offered for a three-year period. The annual gross salary will be about 45.000 Euros. The area of research and teaching is Genetics:


Requested research duties: mechanistic and molecular studies on the processes underlying the genesis and the progression of neurodegenerative diseases, also based on the use of genome-scale approaches.


Requested teaching duties: teaching activity in the subject area of Genetics for Bachelor, Master’s and PhD students.


Link: http://jobs.sciencecareers.org/job/450701/assistant-professor-in-genetics/
Employer: University of Trento
Location: Trento, Italy
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 15th, 2017
University of TrentoTrento, ItalyPhDNDGMay 15, 2017
NEW! Assistant Professor, Neuroimaging

Assistant Professor, Neuroimaging

(Click title to open job details in a new window.)
Description:
Assistant professor to be hired will be working in the research group of Associate Professor Eric Westman which is localized within the Geriatrics Laboratories in the Novum building at KI Campus Huddinge. The focus of the research group has long been on different imaging modalities such as magnetic resonance imaging (MRI) and positron emission tomography (PET) and its applications in neurodegenerative disorders. The assistant professor will work in many different projects related to healthy ageing and dementia, always with as strong focus on neuroimaging and advanced analysis methods such as graph theory.


Duties


A major task for the applicant will be to contribute to the ongoing research activities at the division of clinical geriatrics, conceptually as well as methodologically. In particular, the person is expected to take an active role in our multimodal imaging work, integrating different image modalities, advanced statistical methods and graph theory with genetic, cognitive and biomarker data. Further, there are possibilities to initiate individual research projects, based on the person´s interests.The successful candidate should show a high level of responsibility and independency and be able to work in a team and be willing to supervise students. Moreover, the candidate is expected to have broad knowledge and expertise in aging research and dementia, data gathering and analysis as well as manuscript and grant preparation. Help with coordination of projects within the division and writing grant applications are also duties included as part of the position.


Entry Requirements


A person is eligible to be appointed Assistant professor if he or she has been awarded a Degree of Doctor or has achieved the corresponding scientific competence. The persons appointed should primarily be ones who have been granted a Degree of Doctor or have reached the corresponding competence no more than seven years before the end of the application period.We seek for a scientist with a minimum of four years postdoc experience in the field of neuroimaging in aging, Parkinson’s disease and Alzheimer’s disease research. The candidate should be able to conduct advanced image data processing/analysis (Freesurfer, SPM, FSL and Matlab) and have knowledge about graph theory. The candidate should have previous expertise working Alzheimer’s disease as well as other neurodegenerative disorders.


Bases of assessment


We stress scientific expertise when assessing applicants. A strong track record in terms of publications, as well as research experience in graph theory as well as structural and functional neuroimaging data analysis in Alzheimer’s disease and Parkinson’s disease is required. Documented experience in longitudinal analysis of imaging and behavioral data is desirable. The applicant should also have experience in using a few of the most commonly available imaging software such as Freesurfer, FSL and SPM. The applicant is expected to show independence in terms of research initiatives as well as to have good collaborative skills.


Application process


An application must contain the following documents in English: Curriculum vitae, qualifications and description of planned research, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/qualificationsportfolio).The application is to be submitted through the MyNetwork recruitment system.An Assistant professor position is a fixed-term position. The first employment should be two years, with a possible extension of two years after evaluation.

Link: https://ki.mynetworkglobal.com/se/what:job/jobID:151669/type:job/where:4/apply:1
Employer: Karolinska Institutet
Location: Huddinge, Sweden
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 15th, 2017
Applications close: June 5th, 2017
Karolinska InstitutetHuddinge, SwedenPhDNDGMay 15, 2017
NEW! Postdoctoral Fellow, Respiratory Physiology

Postdoctoral Fellow, Respiratory Physiology

(Click title to open job details in a new window.)
Description:

Applications are being solicited for two NIH post-doctoral fellowships in respiratory neurobiology at the University of Wisconsin-Madison. The first position will investigate cellular mechanisms and physiological significance of neuroplasticity in the control of breathing, with an emphasis on sleep apnea. The second position will investigate functional outcomes of ex vivocell therapy (stem cell-based trophic factor delivery) to preserve respiratory motor neuron and diaphragm function in rodent models of Amyotrophic Lateral Sclerosis (ALS).


Job Duties: Candidates will perform in vivo neurophysiological recordings from phrenic nerves and diaphragm EMGs as part of a highly collaborative team, including respiratory neurobiologists (Tracy Baker, UW-Madison and Gordon Mitchell, University of Florida) and a stem cell biologist (Masatoshi Suzuki; UW-Madison). Although previous experience with in vivoelectrophysiology is desirable, the candidate will be intensively trained in the necessary techniques. Expertise in telemetry implantation, plethysmography, immunohistochemistry, and/or protein and RNA assays are preferred.


Requirements: Ph.D. or equivalent in physiology, neuroscience or a related field. The individual should have strong interest in in vivo experimental approaches. The successful candidate must be a team player, think critically, and communicate effectively. Salary is compatible with NIH pay schedule.


Applications should include a cover letter describing major achievements and skills, a curriculum vitae and contact information of three professional references. Please send applications to Dr. Tracy Baker (tracy.baker@wisc.edu).


Link: http://jobs.sciencecareers.org/job/450119/postdoctoral-positions-in-respiratory-neurobiology/
Employer: University of Wisconsin
Location: Madison, WI
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: May 11th, 2017
University of WisconsinMadison, WIPhDALSMay 11, 2017
NEW! Research Scientist

Research Scientist

(Click title to open job details in a new window.)
Description:

The researcher will be devoted to the development of advanced techniques of in vivo Clinical Biochemistry, in particular metabolic (MR spectroscopy), microstructural and molecular (diffusion tensor imaging) and functional (fMRI) imaging, for the study of the central nervous system and neuromuscular system. The research activity will be applied to inflammatory, neurometabolic, neurodegenerative and neoplastic disorders, aimed to a) the identification of early diagnostic and prognostic markers and surrogate markers of treatment; b) the characterization of brain activations patterns; c) optimization of structural and functional connectivity analysis.


Link: http://jobs.sciencecareers.org/job/450386/central-nervous-system-and-skeletal-muscle-system-evaluation-by-using-biochemical-and-functional-/
Employer: University of Bologna
Location: Bologna, Italy
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 10th, 2017
University of BolognaBologna, ItalyPhDNDGMay 10, 2017
NEW! Postdoctoral Fellow

Postdoctoral Fellow

(Click title to open job details in a new window.)
Description:

We are seeking a Postdoctoral Research Scientist in Cell Based High Throughput Screening for Neurodegeneration who will be responsible for developing cellular assays relevant to neurodegenerative diseases, scaling them down to microtiter format and running phenotypic or target based screenings using CRISPR, si/shRNA or small molecule compound libraries.


You will be a highly organised and productive member of a growing high throughput screening team aiming to manage and deliver multiple projects per year, as well as of the ODDI aiming to develop novel therapeutics for the treatment of dementia. We actively encourage scientists from all disease backgrounds, but with the necessary assay development and cellular screening experience to apply.


You will have a PhD or equivalent expertise, with considerable practical laboratory training and technical expertise in all aspects of high content imaging cellular techniques with particular emphasis on developing and validating cell based assays.


You will have experience in managing several complex projects simultaneously and have meticulous record keeping skill. In addition an established record of authorship and/or examples of successful assay development implemented into high throughput screening format and some experience supporting collaborative grant applications by providing technical scientific input is a desired requirement.


This full-time position is fixed-term for 2 years with the possibility of extension.


Further particulars, including details of how to apply, can be obtained from the document below. Applications for this vacancy should be made online and you will be required to upload a CV and supporting statement as part of your application.


The closing date for applications is 12.00 noon on Thursday 8 June 2017.


Link: https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.display_form?p_process_type=&p_applicant_no=&p_internal_external=E&p_refresh_search=Y&p_recruitment_id=128765&p_display_apply_ind=Y&p_form_profile_detail=&p_display_in_irish=N&p_company=10
Employer: University of Oxford
Location: Oxford, England
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 9th, 2017
Applications close: June 8th, 2017
University of OxfordOxford, EnglandPhDNDGMay 09, 2017
Postdoctoral Fellow, Van Damme Lab

Postdoctoral Fellow, Van Damme Lab

(Click title to open job details in a new window.)
Description:

The Laboratory of Neurobiology is part of the research group Experimental Neurology (Neuroscience Department) at KU Leuven. The group has a close collaboration with the Neurology Department of the University Hospitals Leuven with about 50 researchers in different domains.


In addition, the laboratory is one of the research groups of the VIB Center for Brain & Disease Research (CBD) at KU Leuven/ Campus Gasthuisberg focusing on Neuroscience. There are 13 research groups within the CBD with a total employment of 230 researchers.


The Laboratory focusses on clinical and fundamental research into the prevention, heredity, the pathogenesis and treatment of neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD).


Project:


The research project, under supervision of principal investigator Philip Van Damme, will focus on the neurodegenerative disorder frontotemporal dementia caused by progranulin mutations and will involve in vitro techniques, validation of neuroprotective compounds, iPSCs and small animal models.


Profile


​We are looking for a highly motivated postdoctoral researcher with interest in neurodegeneration and experience in progranulin biology and/or iPSC technology. Motivated candidates with a strong commitment to basic research are invited to apply.


The candidate should hold a PhD degree in biomedical sciences, have experience in research on neurodegenerative disorders, progranulin biology and/or iPSC technology, be able to work in a team, be able to guide and supervise PhD students and should fluently speak and write English.


Link: http://www.vib.be/en/jobs/Pages/Postdoctoral-Researcher-on-new-iPSC-Models-in-Neurodegeneration.aspx
Employer: VIB
Location: Leuven, Belgium
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: May 8th, 2017
VIBLeuven, BelgiumPhDALS, FTDMay 08, 2017
Research Scientist

Research Scientist

(Click title to open job details in a new window.)
Description:

Under general direction of the Principal Investigator (PI), leadership investigators, and project manager, the incumbent will undertake project activities under a CIRM award developing an embryonic stem cell-based therapy to treat Amyotrophic Lateral Sclerosis (ALS), making innovative and significant independent contributions pertaining to achievement of project milestones.


The incumbent must coordinate specific project activities and individuals across multiple functional areas and organizations, including management of routine cell culture, cell biology and molecular techniques, as well as, development and qualification of new clinically translatable analytical methods for characterizing identity and functional activity of pluripotent stem cells and neural lineage cells.


The incumbent will also perform data analysis on mRNA sequencing data and build a database of sequenced cells to support in vivo and in vitro characterization activities and identify potential markers of safety, efficacy and/or disease progression. Additional responsibilities include independent and collaborative organization, outline, evaluation and preparation of scientific data, results, methods, and conclusions in formal and informal formats including presentations, research manuscripts, funding initiatives, and regulatory submissions; and other tasks as required by project investigators.


Link: http://www.cellbiologyjobs.org/jobs/9027565/stem-cell-molecular-biology-researcher
Employer: University of California
Location: San Diego, CA
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: May 2nd, 2017
University of CaliforniaSan Diego, CABA or BSALSMay 02, 2017
Clinical Psychologist

Clinical Psychologist

(Click title to open job details in a new window.)
Description:

We are seeking a Clinical Psychologist with a strong interest in neuroscience and experience in neuropsychological assessment to join a well-established multidisciplinary neuroscience team specialising in early onset and/or rare dementias.


You will be located in the Cerebral Function Unit at Salford Royal NHS Foundation Trust, a tertiary referral diagnostic unit set within a regional neuroscience centre.


The Unit is a clinical academic unit that was set up with the aim of improving clinical services to patients with neurodegenerative disorders by greater accuracy of clinical diagnosis and better understanding of the cognitive and behavioural sequelae of dementia syndromes, including Alzheimer’s disease, frontotemporal dementias and primary progressive aphasias. The unit has an international reputation for research in neurodegeneration.


The primary role of the post-holder is to contribute to a specialist diagnostic service for patients referred to the unit for the purposes of differential diagnosis of dementia.

This is an excellent opportunity to join an outstanding Trust.


Must be a registered clinical psychologist in the UK.


For further details contact Dr Jennifer Thompson by tel. 0161-206-2561 or email jennifer.thompson@manchester.ac.uk


Link: http://jobs.srft.nhs.uk/job/v673304
Employer: Salford Royal NHS Foundation Trust
Location: Salford, England
Sector: Academic
Degree required:
Conditions: FTD
Job posted: May 1st, 2017
Salford Royal NHS Foundation TrustSalford, EnglandFTDMay 01, 2017
Lab Manager

Lab Manager

(Click title to open job details in a new window.)
Description:

The position is for a Lab Manager to help facilitate all daily lab operations. The individual will report to a Principal Investigator (PI) in neuropathology research that investigates the pathogenesis of Alzheimer’s disease, frontotemporal dementia, and related disorders. A successful candidate will have excellent communication skills, highly confident decision making ability, experience managing multiple projects and life sciences lab management, and embrace the highly dynamic environment.

Responsibilities include: maintaining lab consumables inventory, equipment maintenance, communicating with vendors, safety training, and scientist support of a growing Laboratory.


Link: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?partnerid=6495&siteid=5226&jobId=2474136
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: BS
Conditions: FTD
Job posted: April 30th, 2017
University of CaliforniaSan Francisco, CABSFTDApr 30, 2017
Graduate Research Assistant

Graduate Research Assistant

(Click title to open job details in a new window.)
Description:

The laboratory is seeking a motivated Graduate Research Assistant to join our efforts in exploring disease mechanisms and developing therapeutic strategies for amyotrophic lateral sclerosis (ALS) and dementia. There is an increased focus on altered RNA processing as a central component of neurodegeneration in ALS and frontotemporal dementia. Our group explores the role of RNA alterations in neuronal death and uses splicing and expression profiles to identify therapeutic strategies that correct disease-linked gene expression events. The successful candidate will lead a research project using various cellular and animal models of ALS to explore disease mechanisms. Under the supervision of the Principal Investigator, the candidate will design and perform experiments, will participate to the scientific lab meetings and is expected to fully participate in the organization and joint upkeep of the laboratory. He/She will perform laboratory experiments which include DNA and RNA purification, quantitative PCR, gel electrophoresis, Western blots, DNA cloning, immunostaining, preparation of libraries for high throughput sequencing, and mammalian cell cultures. Experience in mouse handling and mouse histology is preferred. The individual must pay attention to details, be capable of working independently under minimal supervision, possess good verbal and written communication skills, and work well as part of a team.


The candidate must be enrolled in a graduate program (MS/PhD Student) in a relevant scientific discipline such as biochemistry, biology, molecular biology or related field.


Link: https://partners.taleo.net/careersection/ex/jobdetail.ftl?job=3038715&src=JB-10326
Employer: Massachusetts General Hospital
Location: Boston, MA
Sector: Academia
Degree required: BA or BS
Conditions: ALS, FTD
Job posted: April 27th, 2017
Massachusetts General HospitalBoston, MABA or BSALS, FTDApr 27, 2017
Assistant, Associate, or Full Professor

Assistant, Associate, or Full Professor

(Click title to open job details in a new window.)
Description:

The Department of Pathology (http://pathology.ucsd.edu) at the University of California San Diego is committed to academic excellence and diversity within the faculty, staff, and student body. We seek exceptional scientists with neurodegeneration research programs for a tenure-track or tenured faculty position at the Assistant, Associate, or Full Professor level. The neurodegenerative disease research community at UC San Diego is highly collaborative.


Candidates must have an M.D. and/or Ph.D. degree, a demonstrated track record of scholarly achievement and research excellence, and an interest in further contributing to the exceptional programs in neurosciences at UCSD through collaboration. Candidates should have an innovative research focus in neurodegeneration. Candidates are also expected to teach as well as perform research training and university service. Qualified candidates will be expected to develop and sustain outstanding extramurally funded research programs. Considerable opportunity exists for collaboration within our robust clinical enterprise and with the UCSD Alzheimer’s Disease Research Center.


Applicants must submit the following documents:


• Cover Letter – The cover letter should contain a brief summary of the proposal, written for a general science audience, highlighting why the research is important and interesting and the applicant’s unique qualifications to pursue this project.

• Curriculum Vitae

• Statement of Research – Statement of current and proposed research is required (not to exceed two pages total).

• Statement of Contributions to diversity – Applicants should submit a separate statement summarizing their past or potential contributions to diversity. (See http://facultyequity.ucsd.edu/Faculty-Applicant-C2D-Info.asp for further information about contributions to diversity statements).

• 3 letters of recommendation


Review of applications will begin on June 20, 2017, and applications will continue to be accepted until the position is filled.


Assistant Professor – (Tenure-Track)

Applications must be submitted through the University of California San Diego’s Academic Personnel RECRUIT system at: https://apol-recruit.ucsd.edu/apply/JPF01389


Associate or Full Professor – (Tenured)

Applications must be submitted through the University of California San Diego’s Academic Personnel RECRUIT system at: https://apol-recruit.ucsd.edu/apply/JPF01390


Link: https://apol-recruit.ucsd.edu/apply/JPF01389
Employer: University of California
Location: San Diego, CA
Sector: Academia
Degree required: MD and/or PhD
Conditions: NDG
Job posted: April 25th, 2017
Applications close: June 20th, 2017
University of CaliforniaSan Diego, CAMD and/or PhDNDGApr 25, 2017
Graduate Studentship, De Vos Lab

Graduate Studentship, De Vos Lab

(Click title to open job details in a new window.)
Description:

Applications are now being invited for a three-year Basic Science PhD Studentship funded by Alzheimer’s Society, starting in October 2017. The successful candidate will join an established training programme at the Sheffield Institute for Translational neuroscience (SITraN) in the group of Dr Kurt De Vos. Expansions of a noncoding GGGGCC hexanucleotide repeat in the C9ORF72 gene are the most common genetic defect found to date in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). How the repeat expansion causes disease is not known, but appears to involve both loss-of-function (C9ORF72 haploinsufficiency), and gain-of-function (repeat-associated non-ATG (RAN) translation, RNA toxicity) mechanisms. To unravel the ways in which C9orf72 expansions cause disease it is crucial to understand the normal functions of the C9orf72 protein. In this project we will investigate how the cellular levels of C9orf72 are regulated and leverage this knowledge to devise novel therapeutic strategies. Candidates must have a first or upper second class honors degree or significant research experience.


How to apply:

Please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply Please clearly state the prospective main supervisor in the respective box and select ‘Neuroscience’ as the department.


Link: https://www.linkedin.com/jobs/view/319502398/
Employer: University of Sheffield
Location: Sheffield, England
Sector: Academia
Degree required: BS
Conditions: ALS, FTD
Job posted: April 14th, 2017
University of SheffieldSheffield, EnglandBSALS, FTDApr 14, 2017
Postdoctoral Fellow, Tamgüney Lab

Postdoctoral Fellow, Tamgüney Lab

(Click title to open job details in a new window.)
Description:

The laboratory of Dr. Erdem Gültekin Tamgüney is focused on understanding how disease-associated proteins misfold, aggregate, spread, and damage the brain. We are inviting applications for a postdoctoral position in this group to work with mouse models of neurodegeneration to elucidate disease mechanisms causing synucleinopathies and amyotrophic lateral sclerosis.


Your profile:

*The successful candidate will be fluent in English.

*At least 3 years of experience in working with mouse models of neurodegeneration, in paraffin- and cryosectioning, in immunohistochemical

and immunofluorescence staining of tissue sections, and in confocal

microscopy.

*Experience in preparing and culturing primary neurons and organotypic

brain slices, in conducting behavioral experiments, in protein purification, or with biophysical methods to study protein misfolding and aggregation is a plus.


Applicants should send a letter of research interests, curriculum vitae and two references as a single PDF File to: application@dzne.de


Link: https://www.dzne.de/en/job-vacancies/job/postdoctoral-researcher-fm-in-animal-models-of-neurodegeneration-code-146220174-1.html
Employer: German Center for Neurodegenerative Diseases (DZNE)
Location: Bonn, Germany
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: April 13th, 2017
Applications close: May 7th, 2017
German Center for Neurodegenerative Diseases (DZNE)Bonn, GermanyPhDALSApr 13, 2017
Postdoctoral Fellow, Sun Lab

Postdoctoral Fellow, Sun Lab

(Click title to open job details in a new window.)
Description:

Postdoctoral opportunities are available in Dr. Shuying Sun’s laboratory at Johns Hopkins University School of Medicine. The lab will explore the fascinating frontiers of RNA metabolism dysfunction and RNA-targeting therapy in neurodegenerative diseases by combining molecular and cellular approaches, genome editing, proteomic, genomic and screening platforms.


The nervous system has extremely complex RNA processing regulation and dysfunction of RNA metabolism has emerged to play crucial roles in multiple neurological diseases. Mutations and pathologies of several RNA-binding proteins are found to be associated with neurodegeneration in both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). An alternative RNA-mediated toxicity arises from microsatellite repeat instability in the human genome. The expanded repeat-containing RNAs could potentially induce neuron toxicity by disrupting protein and RNA homeostasis through various mechanisms.


The Sun lab is interested in deciphering the molecular mechanisms of disease pathogenesis and seeks to translate the mechanistic findings to therapeutic target development to advance treatment options against neurodegenerative diseases. We are looking for highly motivated postdoc fellows with solid PhD training in biochemistry, molecular and cellular biology. Experiences with RNA biology, neuroscience or bioinformatics are preferred but not limited to. You will join a strong and highly interactive science community at Johns Hopkins. Interested candidates should provide a cover letter (with statement of research interest and career goals), CV and the contact information for three references to Dr. Shuying Sun at shuying.sun@jhmi.edu. Please visit our lab website at http://labs.pathology.jhu.edu/sun/ for additional information.


Link: http://www.nature.com/naturejobs/science/jobs/611781-postdoctoral-position-on-rna-biology-and-neurodegenerative-disease
Employer: Johns Hopkins University
Location: Baltimore, MD
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: April 11th, 2017
Applications close: June 10th, 2017
Johns Hopkins UniversityBaltimore, MDPhDALS, FTDApr 11, 2017
Research Associate II

Research Associate II

(Click title to open job details in a new window.)
Description:

Incumbent will assist with new metabolic targets to treat neurodegenerative disease. Under general supervision, assist the principal investigator and laboratory members in developing novel techniques and models to study the intersection between mitochondrial metabolism and neural physiology. Research duties will include assisting with animal handling, tissue harvest, dissections, and primary neural cell preparations. Additional responsibilities will include biochemical assays (immunoblot analysis ,subcellular fractionation), molecular biology (qRT-PCR and genetic manipulation of cells with siRNA, viral vectors, or CRISPR technology), and specialized metabolic assays (Seahorse XF analysis, plate-based enzymatic assays). Preparation of samples for high-content imaging or mass spectrometry analysis will also be required. Further duties will include general lab maintenance responsibilities, such as organization and management of supplies, chemical reagents, and animals.


Job Qualifications

Demonstrated knowledge of basic biochemistry and molecular biology principles. B.S. in Biology, Neuroscience, or related field is preferred. Ability to use basic laboratory equipment, including centrifuge, pH meter, incubators, tissue culture hoods, and electrophoresis apparatus. Demonstrated experience with animal handling, injections, tissue harvests, and dissections. Ability to ensure compliance with all laboratory safety protocols. Ability to learn new methods and protocols and to adapt these to current laboratory situations. Ability to create and maintain records accurately. Ability to work independently and follow through on assignments with minimal supervision, and conduct follow-up experiments based on previous results. Interpersonal and communication skills to effectively interact with a diverse group of faculty, staff, postdoctoral fellows and students and to effectively convey experimental results. Ability to train and supervise undergraduate students. Prior experience with brain dissection, slice cultures, and primary cell preparations from the brain (neurons, astrocytes, etc.) is preferred.


Link: http://www.uclahealthcareers.org/all-jobs/Research-Associate-II/H89695
Employer: University of California
Location: Los Angeles, CA
Sector: Academia
Degree required: BS
Conditions: NDG
Job posted: April 2nd, 2017
University of CaliforniaLos Angeles, CABSNDGApr 02, 2017
Physician Scientist, Tenure-Track

Physician Scientist, Tenure-Track

(Click title to open job details in a new window.)
Description:

The Center for Translational Medicine (CTM) at the Lewis Katz School of Medicine at Temple University is seeking qualified candidates and candidate nominations for a Tenure Track Faculty Physician-Scientist dedicated to neurodegeneration research. This position will also have clinical responsibilities and a joint appointment in the Department of Neurology.


Successful candidates will hold an MD or MD/PhD degree with the ability to obtain a medical license within the commonwealth of Pennsylvania. A focus in basic science or translational research in adult-onset neurodegenerative diseases including Alzheimer’s, Parkinson’s, ALS or Dementia is required, as well as a strong academic record. Academic appointment is available at all levels and competitive packages will be offered based on qualifications. Candidates with current independent funding are preferred.


Interested candidates should submit a current curriculum vita with complete contact information, and letters of interest to the address below. Contributions to diversity are strongly encouraged.


Walter J. Koch, PhD, William Wikoff Smith Endowed Chair in Cardiovascular Medicine, Professor and Chair, Pharmacology, and Professor and Director, Center for Translational Medicine; C/O Debbie Hinnerschitz, DASPR, Physician Recruiter, Lewis Katz School of Medicine at Temple University, 3420 N. Broad Street, MRB 101, Philadelphia, PA, 19140,


Email: debbie.hinnerschitz@tuhs.temple.edu.

Phone: 215-707-4419 Fax: 215-707-9452


Link: http://jobs.sciencecareers.org/job/445609/tenure-track-faculty-research-physician-center-for-translational-medicine-neurodegeneration/
Employer: Temple University
Location: Philadelphia, PA
Sector: Academia
Degree required: MD or MD/PhD
Conditions: ALS
Job posted: March 31st, 2017
Temple UniversityPhiladelphia, PAMD or MD/PhDALSMar 31, 2017
Postdoctoral Fellow, Cai Lab

Postdoctoral Fellow, Cai Lab

(Click title to open job details in a new window.)
Description:

The Department of Cell Biology and Neuroscience at Rutgers University is currently accepting applications for a postdoctoral position to study (1) the cellular mechanisms regulating autophagy-lysosomal function; (2) how altered axonal transport impacts the autophagy-lysosomal system, leading to axonal degeneration; (3) how deficits in the endolysosomal pathway contribute to the dysregulation of neuronal signaling. Given that defective axonal transport has been implicated in the pathogenesis of major neurodegenerative diseases, our studies will yield fundamental information to advance our understanding of human neurodegenerative diseases. Candidates for this position should hold a PhD with a strong research background in neurobiology or cell biology, at least in one of these areas: membrane trafficking, organelle transport, mitochondrial quality control, neuronal signaling, and neurodegenerative mouse models. Interested individuals should send CV, a personal statement describing research interests, and names and details of 3 references to cai@biology.rutgers.edu. Att: Qian Cai, M.D., Ph.D. Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Nelson Biological Laboratories, Busch Campus, 604 Allison Road, Piscataway, NJ 08854. Lab Webpage: https://cbn.rutgers.edu/cb-profile/userprofile/qc29 Application review will begin immediately and will continue until a suitable candidate is selected.


Link: http://jobs.sciencecareers.org/job/445596/postdoctoral-fellow-in-neurobiology-and-cell-biology/
Employer: Rutgers University
Location: Piscataway, NJ
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: March 31st, 2017
Rutgers UniversityPiscataway, NJPhDNDGMar 31, 2017
Postdoctoral Fellow, Talbot Lab

Postdoctoral Fellow, Talbot Lab

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Description:

An exciting opportunity has arisen to work as a Postdoctoral Researcher in Neurodegeneration in the Oxford Motor Neuron Disease Centre based in the John Radcliffe Hospital, Oxford. Working with Professor Kevin Talbot your research will focus on the validation of drugs of potential benefit in ALS, based on targets identified by artificial intelligence approaches. The overarching aims are to use primary cell culture from the TDP-43M337V BAC mouse model to validate drugable pathways in conjunction with industry collaborators and local researchers.


Your responsibilities and duties will include phenotyping cells in culture, including using immunofluorescence and developing skills in electrophysiology, using an established mouse model of ALS based on TDP-43 mutations to validate candidate drugs and adapting existing and developing new scientific techniques and experimental protocols. Your role will also involve you managing your own academic research and administrative activities. This will involve small scale project management, to co-ordinate multiple aspects of work to meet deadlines.


You will have a PhD/DPhil in a relevant discipline or be near to completion with experience of primary neuronal cell culture and a degree in neuroscience or a related subject. You will need to manage your own workload to strict deadlines and work independently as well as contributing to the research activities of the group. Experience of working with induced pluripotent stem cells and mouse models would be advantageous.


For informal inquiries please contact kevin.talbot@ndcn.ox.ac.uk .


For further information about the project please visit: www.ndcn.ox.ac.uk/research/the-oxford-motor-neuron-disease-centre


The post is full-time for a fixed-term of 1 year in the first instance. There is a potential to renew for a further year, dependent on funding


Only applications received before 12.00 midday on Wednesday 26 April 2017 will be considered. Interviews will be held as soon as possible thereafter.


Link: http://www.nature.com/naturejobs/science/jobs/610493-postdoctoral-researcher-in-neurodegeneration
Employer: University of Oxford
Location: Oxford, England
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: March 26th, 2017
Applications close: April 26th, 2017
University of OxfordOxford, EnglandPhDALSMar 26, 2017
Research Specialist

Research Specialist

(Click title to open job details in a new window.)
Description:

A full-time position is available in the laboratory of Dr. Corey McMillan in the Department of Neurology at the University of Pennsylvania. This laboratory focuses on translational neuroscience questions related to improving the diagnostic and prognostic biomarkers of related neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). We also explore genotype and phenotype relationships using a multimodal approach that integrates clinical, imaging, genetic, and biofluid datasets. Applicant responsibilities will include collection of psychometric and imaging data from patients with ALS and/or FTD, preliminary statistical analyses, database management, processing biofluid samples, and administrative coordination with consortia collaborators.


Link: http://jobs.hr.upenn.edu/postings/27064
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: BS
Conditions: ALS, FTD
Job posted: March 24th, 2017
University of PennsylvaniaPhiladelphia, PABSALS, FTDMar 24, 2017
Research Associate

Research Associate

(Click title to open job details in a new window.)
Description:

The position is for a full time Staff Research Associate to assist the PI in neuropathology research that investigates the pathogenesis of Alzheimer’s disease, frontotemporal dementia, and related disorders at UCSF Mission bay campus. The Staff Research Associate is expected to be open to learning new methods. One year of relevant laboratory experience including laboratory histology (embedding, cutting, immunohistochemistry, and coverslipping).The position represents an excellent opportunity to further basic laboratory and research skills in a dynamic clinical neuroscience environment. The successful individual will be an energetic, team player, self-directed learner with a keen interest in research.


Link: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?jobId=2469164&PartnerId=6495&SiteId=5226&codes=IND
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: BA or BS
Conditions: FTD
Job posted: March 23rd, 2017
University of CaliforniaSan Francisco, CABA or BSFTDMar 23, 2017
Assistant, Associate or Full Professor

Assistant, Associate or Full Professor

(Click title to open job details in a new window.)
Description:

The Black Family Stem Cell Institute at the Icahn School of Medicine at Mount Sinai is seeking outstanding applicants (PhD or MD/PhD) for a full-time, potential tenured position at the rank of Assistant Professor, Associate Professor, or Professor. We are a well-established, state-of-the-art research program with a distinguished publication record in stem cell biology and regenerative medicine, laying the scientific groundwork for understanding and manipulating stem cell behavior and developing sophisticated strategies for modeling and treating diseases ranging from blood disorders to neurodegeneration. Preference will be given to outstanding candidates who can complement and enhance existing strengths within the Black Family Stem Cell Institute and work collaboratively with additional world-class researchers at sister institutes at Mount Sinai.


A culture of innovation and a passion for pushing the boundaries of knowledge are integral to all activities at Icahn School of Medicine at Mount Sinai, driving us on a daily basis to challenge existing limitations of science and medicine to create and discover what was previously thought to be impossible. Mount Sinai is at the heart of an exciting and innovative environment and is a friendly and collegial place to work. New York City offers an unrivaled array of cultural and recreational attractions.


Interested candidates should send a copy of their curriculum vitae, a brief letter outlining their interests and names of three references to Thomas Zwaka, MD, PhD thomas.zwaka@mssm.edu by June 1, 2017.


Link: http://jobs.sciencecareers.org/job/443315/black-family-stem-cell-institute-mount-sinai-new-york-full-time-potential-tenured-faculty-position/
Employer: Mount Sinai School of Medicine
Location: New York, NY
Sector: Academia
Degree required: PhD or MD/PhD
Conditions: NDG
Job posted: March 22nd, 2017
Applications close: June 1st, 2017
Mount Sinai School of MedicineNew York, NYPhD or MD/PhDNDGMar 22, 2017
Research Associate, Fraenkel Lab

Research Associate, Fraenkel Lab

(Click title to open job details in a new window.)
Description:

The research group of Professor Ernest Fraenkel seeks a talented scientist to participate in an unprecedented study of the neurodegenerative disease ALS. Working with researchers at clinical and academic institutions across the United States, we are gathering data on approximately 1,000 ALS patients and controls. Induced pluripotent stem cell (iPSC) lines are being derived from each individual and these are being used to generate motor neurons for a wide range of omic studies. Our collaboration seeks to identify different subtypes of the disease, identify correlations between molecular pathways and clinical symptoms, and propose therapeutic strategies.


The research associate will be responsible for generation of epigenomic data from these patient-derived iPSC lines; work closely with collaborators to coordinate the study; and work closely with in-house computational biology team, which is integrating omic and clinical data. Will take a leading role in deriving hypotheses from the computational analyses and designing follow up experiments, using the iPSC lines and post-mortem tissue.


Requirements:


Minimum of two years’ experience with next-generation sequencing technologies, especially ATAC-Seq and ChIP-Seq.

Experience with mammalian cell culture; experience with epigenetic methods and knowledge of neurobiology.

Experience with culturing induced pluripotent stem cells (IPSCs), CRISPR/Cas9 and RNA interference, basic skills in data management and statistical analysis, and high-throughput automation are preferred.

Apply:


For more information, and to apply please visit the MIT website (referencing job #14485) at: http://careers.mit.edu/


Link: https://www.linkedin.com/jobs/view/273974569/
Employer: MIT
Location: Cambridge, MA
Sector: Academia
Degree required: BS
Conditions: ALS
Job posted: March 20th, 2017
MITCambridge, MABSALSMar 20, 2017
Assistant or Full Professor, Chemical Biology

Assistant or Full Professor, Chemical Biology

(Click title to open job details in a new window.)
Description:

Sanford Burnham Prebys Medical Discovery Institute (SBP) is an independent non-profit biomedical research institute that blends world-class fundamental research with drug discovery to address unmet clinical needs in the areas of cancer, neuroscience, immunity, and metabolic disorders. The Institute invests in talent, technology, and partnerships to accelerate the translation of laboratory discoveries that will have the greatest impact on patients. Recognized for its world-class NCI-designated Cancer Center and the Conrad Prebys Center for Chemical Genomics, SBP employs more than 1,100 scientists and staff in La Jolla (San Diego), California, and Lake Nona (Orlando), Florida.


We are seeking junior, mid-career, and senior faculty to engage in cutting-edge research programs in Chemical Biology at SBP. Candidates will have demonstrated expertise in one or more of the following areas of interest: chemical biology, medicinal chemistry, small molecule probe/drug design, pharmacology, structural biology, assay development, and screening technologies. SBP is a highly collaborative environment and the successful candidate will have opportunities to collaborate in multiple areas, including but not limited to, proteostasis, epigenetics, cancer metabolism, immunology/immune-oncology, infectious diseases, ER stress, autophagy, stem cells, neurodegeneration and aging. Sanford Burnham Prebys provides state-of-the-art laboratories and shared resources supported by a collaborative work environment.


The faculty positions require a Ph.D. or M.D./Ph.D. and an outstanding record of publications and research accomplishments relevant to the focus areas. Chosen candidates are expected to establish well-supported, rigorous and competitive research programs based on fundamental mechanisms that can address unmet clinical needs.


To apply for consideration:


Interested applicants should send their CV, together with a cover letter, a short summary of past accomplishments, an outline of future research plans and, for assistant professor candidates, the contact information for 3-4 references to facultyrecruiting@SBPdiscovery.org. All application materials should be sent as a single PDF file with code #cc0317 referenced in the subject line. Applicants are encouraged to visit the web site (www.SBPdiscovery.org) for further information.


Link: http://jobs.sciencecareers.org/job/442028/faculty-opportunity-in-chemical-biology/
Employer: Sanford Burnham Prebys Medical Discovery Institute
Location: La Jolla, CA
Sector: Academia
Degree required: PhD or MD/PhD
Conditions: NDG
Job posted: March 17th, 2017
Sanford Burnham Prebys Medical Discovery InstituteLa Jolla, CAPhD or MD/PhDNDGMar 17, 2017
Postdoctoral Fellow, Farese-Walther Lab

Postdoctoral Fellow, Farese-Walther Lab

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Description:

We have a postdoctoral position available in the laboratory of HHMI Investigator, Tobias Walther, Ph.D., and Robert V. Farese, Jr, M.D., who jointly run a highly collaborative group at the Harvard School of Public Health. The lab is located in the Boston Longwood medical campus and is affiliated with the Department of Genetics and Complex Disease (HSPH), the Department of Cell Biology (Harvard Medical School), the Broad Institute of MIT and Harvard, and the Howard Hughes Medical Institute.


The Walther-Farese Laboratory studies the biochemistry of cellular lipid metabolism and membrane homeostasis. We seek outstanding candidates with Ph.D. training in cellular and murine models of neurodegeneration. Projects are available in the areas of lyososome biology and frontotemporal dementia and in the area of altered sphingolipid homeostasis and neurodegenerative diseases.


Applicants should possess a Ph.D. or M.D./Ph.D. in cell biology or neurodegenerative disease research and have an outstanding publication record.


For Additional Information, Please Visit Our Webpages

https://faresewaltherlab.hms.harvard.edu/

http://cellbio.med.harvard.edu/people/faculty/farese-jr

http://cellbio.med.harvard.edu/people/faculty/walther

https://www.hhmi.org/scientists/tobias-c-walther


To Apply

Interested candidates should send a cover letter, Curriculum Vitae and three letters of reference to: robert@hsph.harvard.edu and tholmes@hsph.harvard.edu. Please include the position title, Postdoctoral Position – Cell Biology/Neurodegenerative Diseases, in the subject line.


Link: https://www.linkedin.com/jobs/view/272686325/
Employer: Harvard School of Public Health
Location: Boston, MA
Sector: Academia
Degree required: PhD or MD/PhD
Conditions: NDG
Job posted: March 16th, 2017
Harvard School of Public HealthBoston, MAPhD or MD/PhDNDGMar 16, 2017
Postdoctoral Fellow, Sajjadi Lab

Postdoctoral Fellow, Sajjadi Lab

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Description:

The Department of Neurology at the University of California, Irvine, invites applications for a post-doctoral fellow position in the laboratory of Dr. S. Ahmad Sajjadi MD, PhD beginning early 2017. The appointment is for 1 year with the possibility of extension upon satisfactory performance. We are seeking a highly motivated investigator with previous experience in neuropsychological assessments. Priority will be given to candidates with a recent PhD in neuroscience, psychology, or related fields and strong organizational and communication skills. The main purpose of this appointment is to establish a cohort of atypical dementia syndromes (mainly frontotemporal dementia) at the University of California, Irvine who will undergo regular clinical and neuropsychological assessments. Assessment of language and spontaneous speech will be a focus of the research and therefore, background in disorder of language will be desirable as is previous experience in neuro-imaging acquisition/analysis since the project will include structural MRI and PET scans. The position requires an individual who is an effective team player, highly organized, and innovative.


Requirements:

Candidates must possess an advanced Degree (MD or PhD) by or prior to appointment start date.


Additional Information:

Applicants who have a willingness to get involved with IRB communications, prior publication (first author), and strong written and verbal communication skills are preferred.


Salary will be commensurate with qualifications and experience.


Substantive inquiries about the positions should be directed to:

Seyed Ahmad Sajjadi, MD, PhD

Assistant Professor

Department of Neurology

200 S. Manchester, Ste. 2016

Orange, CA 92868-4280


TO APPLY: Please log onto UCI’s RECRUIT by May 12, 2017, at: https://recruit.ap.uci.edu/apply/JPF03828


Applicants should complete an online application profile and upload the following application materials electronically to be considered for the position:


Cover letter—Please discuss current research and future plans.

Curriculum vitae

Names and Contact Information of Three References

Diversity Statement


Link: https://recruit.ap.uci.edu/apply/JPF03828
Employer: University of California
Location: Irvine, CA
Sector: Academia
Degree required: MD or PhD
Conditions: FTD
Job posted: March 14th, 2017
University of CaliforniaIrvine, CAMD or PhDFTDMar 14, 2017

Industry

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Research Associate II/III

Research Associate II/III

(Click title to open job details in a new window.)
Description:

Summary


We are seeking a talented Research Associate to join VelociGene’s neurodegenerative disease research team. The individual will be involved in basic research studies designed to understand the biology behind various neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis, Alzheimer’s, Parkinson’s, and Huntington’s.


Responsibilities


The goal will be to identify and validate novel therapeutic targets and mechanisms. Additionally, this position will support and expand the development of new technologies, to this same end. This candidate will work within a multi-disciplinary group; we are looking for a highly organized, flexible and motivated research associate.


Requirements



  • Experience in molecular and cellular biology and biochemistry

  • Experience with cell based assays (Western Blot, ELISA, FACS) preferred

  • Experience in creating and managing vector constructs and projects

  • Experience with mammalian tissue culture

  • Experience in the maintenance and differentiation of embryonic stem cells

  • Experience with CRISPR and other genome editing tools a plus

  • Excellent communication skills and computer proficiency are also required

  • This position requires a minimum of a BS or MS degree and 0-4 years of relevant experience.

  • At least two years’ postgraduate experience. Experience in a neurobiology lab would be highly desirable. Equivalent industrial experience would also be acceptable.

  • A high level of skill in cellular and molecular biology and biochemistry experimental techniques

  • Preferred knowledge would include neurobiology and the growth and maintenance of cells of the nervous system; knowledge of protein homeostasis, protein folding, and quality control mechanisms and protein aggregation

  • Ability to work independently with limited supervision but also be a productive and cooperative member of a diverse research team.

  • Ability to manage multiple projects


Link: http://careers.regeneron.com/job/REGEA0026303504/Research-Associate-II-III-Neurodegenerative-Diseases
Employer: Regeneron
Location: Tarrytown, NY
Sector: Industry
Degree required: BS or MS
Conditions: ALS
Job posted: May 16th, 2017
RegeneronTarrytown, NYBS or MSALSMay 16, 2017
Scientist, Neuroscience

Scientist, Neuroscience

(Click title to open job details in a new window.)
Description:

Genentech is inviting applications for a Scientist position (rank equivalent to assistant professor in academia) in the Department of Neuroscience. We are seeking an exceptional, highly motivated and creative scientist to lead innovative research efforts focused on unraveling the mechanisms of neurodevelopment and/or brain function in the context of nervous system diseases. He/she will also be expected to participate in inter-disciplinary teams to identify novel drug targets and discover new drugs to treat nervous system disorders. The ideal candidate will have significant experience in molecular and cellular biology using both in vitro and in vivo model systems, and possess a deep mechanistic understanding of the cellular pathways that contribute to diseases of the nervous system (e.g. neurodegenerative diseases). A solid track record of publications in top tier journals is required as is exceptional communication skills. The position will involve close collaboration with other research labs in Neuroscience as well as investigators in areas such as human genetics, bioinformatics, proteomics, imaging, and small molecule and large molecule drug discovery. The successful candidate will be expected to publish their research in high quality journals.


As a strong candidate, you will have:

PhD with postdoctoral research experience in cell biology, neuroscience or related areas in life sciences.

Record of impactful research in molecular cellular biology, neuroscience, or related fields, as evidenced by recent first authored publications in top-tier journals.

Excellent written and oral communication skills

The drive and ability to lead an independent research group and collaborate with other investigators

Outstanding promise of future scientific achievement


Link: https://www.gene.com/careers/detail/3398510619/Scientist-Neuroscience-Genentech-Research
Employer: Genentech
Location: San Francisco, CA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: May 4th, 2017
GenentechSan Francisco, CAPhDNDGMay 04, 2017
Director, Neurobiology

Director, Neurobiology

(Click title to open job details in a new window.)
Description:

Verge Genomics is seeking a motivated and accomplished Director of Neurobiology with experience using in vivo pharmacology models to translate in vitro compound hits to optimized drug leads. You will lead in vivo studies to validate small molecule efficacy and minimize side effect potentials and establish proof of concept by the manipulation of gene targets to ameliorate or create disease models. The ideal candidate will apply a combination of his or her expertise in the etiology and treatment of ALS, Parkinson’s and Alzheimer’s disease, results from our cell-based screens, and animal studies you will lead to best apply gene networks to guide our drug discovery efforts. With knowledge of neuropharmacology and experience translating compound discoveries to CNS applications, this position offers the opportunity to help lead the neurobiology research program at an emerging biotech company.


Link: https://jobs.lever.co/vergegenomics/3466c961-e166-4658-8a62-0bb99545795e
Employer: Verge Genomics
Location: Ann Arbor, MI
Sector: Industry
Degree required: PhD
Conditions: ALS
Job posted: May 2nd, 2017
Verge GenomicsAnn Arbor, MIPhDALSMay 02, 2017
Director/Sr. Director, Neurodegeneration and Repair Research

Director/Sr. Director, Neurodegeneration and Repair Research

(Click title to open job details in a new window.)
Description:

We are looking for a talented leader to direct preclinical research in Dementia and Memory Disorders within the new Neurodegeneration and Repair Research Unit. In close partnership with the early clinical lead for within the same unit, the successful candidate will be responsible for delivering innovative drug candidates for proof-of-concept trials in AD, FTD and other memory disorders. He/she will lead the efforts of multiple research teams from early target discovery to late preclinical development and support the clinical trial strategy. We seek a candidate with knowledge of the biology of neurodegeneration and an outstanding track record in the field of drug development. He/she will succeed by collaborating closely with other Biogen scientists and clinicians in the areas of neurodegeneration, neuroimmunology and repair, as well as experts in the multiple therapeutic modalities – small molecules, antibodies, biologics, antisense oligonucleotides and gene therapy – in the Biogen portfolio. An innovative approach to biomarker and drug delivery strategies will also be required. We particularly seek candidates who have demonstrated strong scientific rigor while exploring novel pathways and mechanisms in humans and model systems and in leading multidisciplinary research teams. Demonstrated expertise in Alzheimer’s research and experimental models would be an advantage but is not required.


Link: https://jobs.biogen.com/job/Cambridge-DirectorSr_Director%2C-Neurodegeneration-and-Repair-Research-MA-02138/374546100/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD or PhD/MD
Conditions: FTD
Job posted: May 2nd, 2017
BiogenCambridge, MAPhD or PhD/MDFTDMay 02, 2017
Associate Director or Senior Manager, Business Development and Alliance Management

Associate Director or Senior Manager, Business Development and Alliance Management

(Click title to open job details in a new window.)
Description:

In conjunction with and reporting to the Sr. Vice President of Business Development, the Senior Manager/Associate Director, Business Development and Alliance Management will focus on building value through strategic alliances and/or licensing transactions.


The responsibilities for this position involve serving as a cross-functional leader working in close coordination with key senior staff and consultants (e.g., within Commercial Development, Intellectual Property and Legal Affairs, Finance, Project Management and R&D) and engaging with our partners and potential partners at all levels.


This individual will:


Serve as a key contact for existing partners and on the team responsible for identifying, evaluating, negotiating, and executing new strategic alliances and/or licensing transactions.

Participate in Cytokinetics’ strategic planning process.

Develop and maintain strong internal and external relationships to facilitate effective execution of business development campaigns, including due diligence, terms development and negotiation.

Ensure effective partnership governance and planning.

Provide guidance to others working on Cytokinetics’ partnerships and lead initiatives to enhance business development and alliance management capabilities.


Qualifications:


A minimum of 7 years of post-baccalaureate experience in the biotechnology/pharmaceutical industry is required. Based on years of relevant experience, candidates at the Manager level may be considered.

Advanced degree (e.g., M.B.A., J.D., Ph.D., etc.) with a relevant technical degree.

Track record of productive participation in a business development or alliance management role.

Experience with negotiating and/or managing contractual relationships, including firm understanding of IP/licensing fundamentals.

Excellent analytical capabilities, strong interpersonal and communication skills, demonstrated creativity, flexibility and problem-solving ability, solid knowledge base regarding business development and alliance management practices and trends, and proven ability to work effectively in a team environment with interactions across multiple, diverse disciplines


Link: https://cytokinetics.com/company/careers/job-opportunities/
Employer: Cytokinetics
Location: San Francisco, CA
Sector: Industry
Degree required: PhD, MBA or JD
Conditions: ALS
Job posted: April 18th, 2017
CytokineticsSan Francisco, CAPhD, MBA or JDALSApr 18, 2017
Clinical Research Fellow, Neuromuscular Diseases

Clinical Research Fellow, Neuromuscular Diseases

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Description:

We now offer a unique opportunity to an academic clinical neurologist to join our team as a Clinical Research Fellow in Neuromuscular Diseases. During a negotiable 1-2 year commitment based at Cytokinetics’ offices in South San Francisco, the Fellow will contribute invaluable expertise to our clinical development programs in neuromuscular diseases. The Fellow will benefit from an experience rarely available in a strictly academic position; i.e., the day-to-day leadership and management of a clinical trial aimed at the development of new therapeutics for patients. The Fellow may engage in this opportunity in the context of their academic fellowship as a means to satisfy a research requirement if agreeable to their institution. Continued involvement in the clinical management of patients during the period of this fellowship will be encouraged. The Fellow may return to his or her academic post at the conclusion of the term, enriched by this experience in addition to returning to the parent institution with a portfolio of valuable clinical research competencies.

The Fellow will report to the Clinical Director of Neuromuscular Therapeutics at Cytokinetics. Compensation will be at industry-competitive standards commensurate with experience and a benefit package can be provided. In participating in clinical trials, the Fellow will also participate in our collaboration with Astellas as a member of the Project Team, clinical advisory board management; protocol design; clinical trial site recruitment, initiation, and monitoring; and data interpretation and reporting.


Responsibilities:

Serve as a primary source of neuromuscular expertise for the study management team, clinical project team, and other internal and external stakeholders as required.

Provide input to decisions that have medical, scientific, and future marketing implications for Cytokinetics’ investigational new drugs that may eventually treat a broad array of neuromuscular diseases.

Contribute to the design, planning, initiation and completion of clinical trials in neuromuscular diseases.

Liaise with scientists within and outside of Cytokinetics to inform our basic and translational research on skeletal muscle activators.

Author the medical components of key documents, including study protocols and related regulatory submissions.

Manage communications and relationships with other prominent clinical investigators and thought leaders in neuromuscular diseases.

Represent Cytokinetics at scientific and patient-focused meetings related to neuromuscular diseases.

Help to implement Cytokinetics’ clinical development strategies during interactions with regulatory authorities such as FDA and EMA.

Monitor and interpret the accumulating clinical safety data for Cytokinetics’ investigational new drugs.


Qualifications:


MD, MD/PhD, or DO degree with neurology board certification or eligibility by the American Board of Psychiatry and Neurology

Experience in the management of patients with SMA is desired; experience with clinical trials of therapeutics intended for the treatment of SMA or other neuromuscular diseases and expertise in muscle physiology and nerve cell function would be a critical advantage

Excellent written and verbal communication and presentation skills

Strong interpersonal and leadership skills

Ability to work within a multidisciplinary team


Link: https://cytokinetics.com/company/careers/job-opportunities/
Employer: Cytokinetics
Location: San Francisco, CA
Sector: Industry
Degree required: MD, MD/PhD, or DO
Conditions: ALS
Job posted: April 18th, 2017
CytokineticsSan Francisco, CAMD, MD/PhD, or DOALSApr 18, 2017
Director, Clinical Pharmacology

Director, Clinical Pharmacology

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Description:

Reporting to the EVP Research & Development, the Director, Clinical Pharmacology will be responsible principally for early clinical drug development activities with a strong focus on Phase I and Phase IIa clinical trials. He/She will work closely with the Clinical Research Group and other members of the R&D team to ensure a strategic view is taken for the pipeline progression of individual projects.


Responsibilities:

Design Phase I and Phase IIa clinical studies, including dose escalation, stopping rules and risk-benefit to ascertain that compounds are entered into man safely, efficiently and with scientific validity.

Responsible for the medical content of clinical pharmacology studies.

Responsible for the medical aspects of clinical pharmacology components related to regulatory documents and interact with regulatory authorities for all phases of drug development.

Medical monitor in sponsored studies as appropriate, ensure that the clinical teams correctly handle all adverse events (AEs) and serious adverse events (SAEs) in accordance with ICH standards.

Correctly apply the ICH and GCP regulations surrounding the primary activities of clinical development projects.

Operate within the time and budget constraints of the clinical program.

In collaboration with the Chief Medical Officer, train members of the product development team to enhance their skills.

Communicate project-related information, including the planning and execution of meetings and presentations.

Coordinate and complete scientific documents including protocols, clinical study reports, other regulatory documents.

Travel up to 30% as necessary according to project needs.


Qualifications:

Registered Medical Doctor (mandatory qualification).

Board certification/specialist registration in clinical pharmacology highly desirable or significant prior relevant experience

PhD in clinical pharmacology would be an asset.

At least 5 years of experience in drug development in the pharmaceutical and/or biotech industry, covering both early and translational phase development or significant participation in industry sponsored research as a clinical investigator.

Randomized controlled clinical trial principles, methodology and procedures.

Adverse medical event investigation, analysis, as well as reporting procedures and standards.

FDA and EMA regulatory requirements and ICH/GCP guidelines is an asset.

Federal and state regulations and guidelines pertaining to the conduct of clinical trials on human subjects.

Statistical data collection, editing, validation and analysis techniques.

Current and developing trends and standards in clinical trials monitoring.

Industrial standards as applied to GCP and GLP.

Infrastructure and operational characteristics of Contract Research Organizations (CROs) and centralized clinical laboratories.

Ability to develop and implement clinical research monitoring plans and study specific procedures.

Ability to establish data collection and management guidelines.

Ability to communicate, interact and present competently and professionally both verbally and in writing at all levels within a broad, complex clinical research environment including third parties such as CRO’s and academia.


Link: https://cytokinetics.com/company/careers/job-opportunities/
Employer: Cytokinetics
Location: San Francisco, CA
Sector: Industry
Degree required: MD
Conditions: ALS
Job posted: April 18th, 2017
CytokineticsSan Francisco, CAMDALSApr 18, 2017
Research Scientist

Research Scientist

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Description:

We are looking for an experienced BS or MS degreed research scientist to join the Neuroscience department. The candidate will play a hands-on role in a highly collaborative team responsible for research on neurodegenerative diseases. You will conceive, conduct, and analyze experiments to identify and evaluate compounds or biologics in various assays and cellular models. These include but are not limited to bioanalytical and biochemical assays, human ES/iPS derived neuronal models, and analysis of tissue samples.


The candidate will have a B.S. or M.S. degree or equivalent in biochemistry, cell biology, neurobiology or a similar discipline with 6-12 years of research experience. Previous experience in industry and/or with neurodegenerative diseases is a plus. The candidate must be highly collaborative, self-motivated, team-oriented, and have excellent communication and computer skills.

A variety of laboratory techniques will be used to rapidly progress therapeutic ideas from concept to results. Expertise in some of the areas listed below is required, but we also expect that candidate will develop new skills as needed to address the emerging biological questions.


•Protein biochemical analysis of cell lysates and mouse and human tissue.

•High-throughput cellular and biochemical assay development, and familiarity with analysis of large data sets including high-content imaging data.

•General cellular and molecular laboratory techniques such as cloning, lentiviral production, and flow cytometry.

•Conventional cell culture, cell line engineering, and cell-based assay development. Experience in pluripotent stem cell culture, differentiation, and CRISPR/CAS9 genome engineering is a plus.


Link: https://sjobs.brassring.com/TGWEbHost/jobdetails.aspx?partnerid=13617&siteid=5268&Areq=209999BR&codes=13335
Employer: Novartis
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: March 31st, 2017
NovartisCambridge, MABS or MSNDGMar 31, 2017
Senior Associate Scientist

Senior Associate Scientist

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Description:

Position Overview:


Yumanity is seeking a talented and versatile BS/MS scientist to join our interdisciplinary team to help advance novel drug discovery programs for neurodegenerative diseases. This position will be laboratory based, and requires strong experimental skills with background in cell and molecular biology and experience in quantitative assay development. The successful candidate must be highly flexible and team-oriented. The position will report to a Principal Scientist in the Mammalian Assay Development group, and will interact across all of Yumanity’s core platforms, including yeast phenotypic screening, target identification, stem cells and chemistry.


Responsibilities include:


*Assist in developing neurodegenerative disease models in mammalian cells; including cell lines, rodent primary neurons and iPS cell-derived neurons.

*Assist in developing assays to validate the activity and targets of small molecules identified from yeast phenotypic screening and target identification activities.

*Directly interact and collaborate with the medicinal chemistry team to evaluate identified and novel small molecule activity and properties.

*Generate and maintain embryonic rodent primary neurons to assist with development of neurodegenerative disease models and assays.

*Analyze and interpret experimental data, address methodological challenges in experimental protocols and clearly convey results to the team in oral and written fashion.

*Maintain accurate and up to date documentation of all laboratory activities (notebooks, databases).

*Independently operate and oversee maintenance of selected lab equipment.

*Consult scientific literature as needed.


Experience and skills required:


*A Bachelor’s (+5 yrs experience) or Master’s (+3 yrs experience) degree in biology or related discipline.

*Proficiency in basic lab techniques (Mammalian cell culture, ELISA, Western Blot, rtPCR) and principles of cell biology, biochemistry or molecular biology required.

*Proficiency in rodent embryonic brain dissection and harvesting primary neurons techniques is highly desirable.

*Experience in assay development.

*Knowledge of relevant scientific databases is preferred.


Link: http://www.yumanity.com/careers/
Employer: Yumanity Therapeutics
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: March 30th, 2017
Yumanity TherapeuticsCambridge, MABS or MSNDGMar 30, 2017
Senior Associate Scientist

Senior Associate Scientist

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Description:

We are seeking a Research Senior Associate Scientist to join a vibrant and growing group currently focusing on Neurodegenerative diseases within the Neuroscience Therapeutic Area, a key component of the Discovery Research unit at Amgen’s site in Cambridge, MA (Amgen MAssachusetts-AMA). The successful candidate must be highly motivated with a deep interest in developing new and effective therapeutics for Parkinson’s disease (PD)/ALS.


Position Responsibilities

*Conduct biochemical and cell-based experiments/assays to evaluate novel mechanisms and interrogate the biology of new therapeutic targets for PD/ALS

*Carry out experiments required to rigorously evaluate in-licensing opportunities

*Critically analyze and interpret data, and meet delivery deadlines

*Work closely with and communicate results to multi-disciplinary and cross-functional teams

*Execute high impact studies within an extremely fast-paced and collaborative environment


Preferred Qualifications

*Master’s Degree in Neuroscience

3+ years of experience in neuroscience and neurodegenerative diseases

*Experience/expertise in culturing primary neurons, iPSC-derived neurons and immortalized cell lines

*Experience with CRISPR and iPSC technology

*Experience developing a wide range of cell-based assays, and in interrogating a variety of cellular signaling pathways

*A high degree of computer literacy and excellent analytical/problem-solving skills

*Good organizational skills with the ability to independently design and execute experiments, and interpret results

*Outstanding interpersonal and communication skills, and superior multi-tasking abilities

*Highly motivated and adaptable individual who enjoys working in a team environment and welcomes new challenges.


Link: https://amgen.wd1.myworkdayjobs.com/en-US/Careers/job/US---Massachusetts----Cambridge/Sr-Associate-Scientist---Parkinson-s-Disease---ALS_R-36298
Employer: Amgen
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: ALS
Job posted: March 28th, 2017
AmgenCambridge, MABS or MSALSMar 28, 2017
Senior Scientist, Neuroinflammation

Senior Scientist, Neuroinflammation

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Description:

The Merck Early Discovery Neuroscience team is seeking a highly motivated and technically skilled neuroscientist with a strong background in neuroimmunology to join our Boston-based early drug discovery team. Position is for a lab-based biologist who will generally be responsible for supporting the identification and validation of novel targets. The primary responsibilies will include the design and execution of both in vitro experiments and in vivo studies – applying biochemical, cellular/molecular, histological and imaging techniques – to drive toward a deeper understanding of disease pathogenesis, establish novel models thereof, and enable mechanism of action assessments for candidate therapeutics. The Senior Scientist will be an active participant in the critical scientific dialogue that supports our mission of early discovery in support of the Merck Neuroscience pipeline.


The responsibilities of the Senior Scientist include:


– Characterize the complex interplay between neurons, glial cells and disease pathogenesis in animals models of neurodegeneration.

– Collaborate to develop disease relevant cellular models using primary neurons and glia.

– Analyze, summarize and communicate data clearly and concisely to teams and stakeholders.

– Monitor, review and critically interpret published work to guide internal research.

– Collaborate with members across diverse functional areas, including but limited to colleagues from genetics, medicinal chemistry, in vivo and in vitro pharmacology, chemical biology and translational sciences.

– Work with external academic, biotechnology, and contract research organizations


Link: http://jobs.sciencecareers.org/job/443381/senior-scientist-neuroinflammation-boston-job/
Employer: Merck
Location: Boston, MA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: March 24th, 2017
MerckBoston, MAPhDNDGMar 24, 2017
Research Associate

Research Associate

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Description:

Nuredis, Inc. discovers and develops small molecule therapies for a group of inherited neurodegenerative and neuromuscular diseases, aiming to treat the cause of disease rather than just managing symptoms. Nuredis was founded in 2016 based on technology licensed from Stanford, with facilities in Menlo Park. We are currently seeking self-driven, intelligent individuals to add their complementary talents to our highly-motivated team.


Purpose


Nuredis seeks a qualified candidate to fill the position of Research Associate. This person will perform basic functions and research activities to contribute to development of therapeutic agents. Duties will include conducting and analyzing experiments under the supervision of Scientists, as well as managing lab equipment, records, and supplies.


Minimum Qualifications


B.S. OR M.S. in Biology, Biochemistry, Molecular Biology, Neurobiology or related field, plus at least two years of laboratory experience

Comprehensive understanding of molecular and cell biology principles

Strong interpersonal skills and ability to work in a team with many different researchers

Computer literacy in Microsoft Office (Word, Excel, and PowerPoint)


A qualified candidate will have experience and/or relevant education in the following areas:


*Nucleic acid and protein handling, including isolation of these molecules from cell or tissue samples, RT-PCR, Western blotting, etc.

*Tissue culture, with the following duties: thaw, grow, passage, count, analyze and freeze cell lines of diverse types from multiple sources; monitor cultures for contamination; use and maintain the cell line record database; experience with iPSC lines is a plus

*Lentiviral transduction of cultured cells, with demonstrated knowledge of the appropriate BSL-II safety requirements (training, technique, proper Personal Protection Equipment) for safe handling of viruses

*Plan and perform experiments with minimal supervision, using reasonable personal judgment and knowledge of basic laboratory techniques and protocols; in collaboration with supervisors and colleagues, contribute to analysis and interpretation of results and data; and use experience and observations to optimize protocols and assays

*Maintain timely and detailed records of experiments, results and analysis

*Review current literature to remain knowledgeable of new procedures and related research

*Contribute to publications and presentations, as appropriate

*General lab maintenance and support; share tasks with other members of the lab that may include maintaining stock reagents, managing chemical and reagents inventories, maintaining safety and other lab documentation, managing inventory, and ordering of lab supplies and reagents


To apply, please email your cover letter and resume to HR(at)nuredis(dot)com, with the subject line “Nuredis Application: Research Associate.”


Link: https://www.indeed.com/cmp/Nuredis,-Inc./jobs/Research-Associate-3c0216c1dd418032
Employer: Nuredis
Location: Menlo Park, CA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: March 23rd, 2017
NuredisMenlo Park, CABS or MSNDGMar 23, 2017
Associate Scientist III, Neuroimmunology

Associate Scientist III, Neuroimmunology

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Description:

The Biogen Department of Neuro/Immunology seeks a highly motivated and keen associate scientist whose primary responsibility is to advance target validation, drug discovery and development. The individual is expected to have mastered a broad range of experimental techniques, preferably having established expertise in the field of neuroimmunology. The individual will be expected to perform with significant independence with respect to designing and executing controlled experiments, analyzing and interpreting results, establishing and executing existing or new protocols/methodologies and recommending modifications. The individual is expected to read pertinent literature and exhibit knowledge of molecular and biological processes, applying their knowledge to propose new ideas and regularly make suggestions for creative solutions to technical challenges. The individual is expected to have strong written and verbal communication skills, preparing and delivering oral presentations, posters, draft research reports and contributing to manuscripts.


Responsibilities include:


•Driving target validation efforts for neurodegenerative diseases such as Alzheimer’s, Parkinson’s and ALS, with a particular focus on glial cells and neuroinflammation.


•Using a wide array of techniques relevant to neuroimmunology and glial cells


•Leveraging animal models of neuroinflammation and neurodegeneration to demonstrate proof-of-biology; knowledge and experience with such models is preferred.


•Designing and executing experimental plans, performing rigorous analysis and interpretation of experiments.


•Collaborating with relevant individuals and groups to advance projects; demonstrating good lab citizenship.


• Skilled experimentation encompassing a wide array of in vitro and in vivo techniques; relatively independent design, execution, analysis and interpretation of experiments.


• Strong oral and written presentation of technical work


• Collaboration with relevant individuals and groups to advance projects; demonstration of good lab citizenship.


Link: https://jobs.biogen.com/job/Cambridge-Associate-Scientist-II%2C-Research-MA-02138/376780100/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: ALS
Job posted: March 17th, 2017
BiogenCambridge, MABS or MSALSMar 17, 2017
Senior Associate Scientist, Neuroimmunology

Senior Associate Scientist, Neuroimmunology

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Description:

The Neuroimmunology department at Biogen is searching for a committed, enthusiastic and dependable associate scientist to assist with the design, execution and interpretation of preclinical studies for drug discovery and development. The incumbent will be part of a multifunctional team with responsibility for target validation and evaluation of novel drug candidates for neurodegenerative/neuroinflammatory diseases. He/she should be able to plan and execute in vivo and in vitro experiments with high level of independency, organization and scientific rigor. He/she should be able to maintain an up-to-date knowledge of pertinent literature and possess excellent communication and interpersonal skills to efficiently present results to project team members.


Link: https://jobs.biogen.com/job/Cambridge-Associate-Scientist-II%2C-Research-MA-02138/371072000/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: March 15th, 2017
BiogenCambridge, MABS or MSNDGMar 15, 2017

Non-Profit and Government

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
Biocuration Scientist

Biocuration Scientist

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Description:

The Biocuration Scientist is responsible for the ongoing curation of scientific databases and directories that serve the neurodegeneration research community. The databases reflect the breadth of AD research and include information on research models, mutations, biomarkers, therapeutics, and other aspects of research on AD and related disorders. The Biocuration Scientist collaborates with the scientific content manager and other Alzforum staff members to ensure that information is accurate, up to date, and consistent across the website.


Primary Responsibilities


*Review and assess the scientific literature on AD and related neurodegenerative diseases to identify relevant data for Alzforum databases and directories

*Create and update database entries, succinctly summarizing research findings

*Communicate with scientists, companies, and vendors as necessary to solicit and clarify information

*Collaborate and advise on the ongoing maintenance and design of the databases


Qualifications


*Experience with bench research in an academic or industry laboratory

*Domain knowledge of neurodegenerative disease research

*The ability to work well with a team and independently with accuracy and attention to detail

*Excellent verbal and written communication skills

*Ability to distill complex scientific information into clear, succinct prose

*Outstanding organizational skills with proven ability to set and meet deadlines

*Familiarity with Photoshop and Adobe Illustrator preferred


Link: http://www.alzforum.org/jobs/biocuration-scientist
Employer: Alzforum
Location: Boston, MA
Sector: Non-Profit
Degree required: PhD
Conditions: NDG
Job posted: April 12th, 2017
AlzforumBoston, MAPhDNDGApr 12, 2017
Research Assistant I/II, Lutz Group

Research Assistant I/II, Lutz Group

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Description:

The group of Dr. Cathleen Lutz has openings for full-time positions at the Research Assistant level. Our group focusses on the development and characterization of mouse models for human diseases, with an emphasis on optimal use and best practices for research and preclinical drug development. The laboratory works with the NIH, disease foundations and the pharmaceutical industry to improve on existing mouse models and generate new ones, identify modifier genes, and develop assays that facilitate therapeutic development. Our overarching goal is to work with the scientific community to facilitate the rapid characterization, standardization and consistent use of mouse models, with the aim of accelerating treatment discovery. Current projects are focused on Spinal Muscular Atrophy, Friedreich’s Ataxia, Amyotrophic Lateral Sclerosis, Duchenne Muscular Dystrophy and Rett Syndrome.


This position will involve performing general laboratory routine procedures such as laboratory maintenance, mouse colony husbandry and genotyping, samples collection, clinical evaluation, molecular biology and biochemistry (e.g. PCR, western and southern blotting, RNA analyses), and operating, after training, advanced phenotyping tools such as metabolic cages, electrophysiology recorders, etc.


A cover letter outlining general interests and career goals should be submitted with Resume as one document to consider application complete.


Link: https://jax.silkroad.com/epostings/index.cfm?fuseaction=app.dspjob&jobid=220728&company_id=15987&version=2&jobBoardId=3345
Employer: The Jackson Laboratory
Location: Bar Harbor, ME
Sector: Non-Profit
Degree required: BA or BS
Conditions: ALS
Job posted: April 8th, 2017
The Jackson LaboratoryBar Harbor, MEBA or BSALSApr 08, 2017
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