Figure 1B Amplitude of low frequency fluctuation  (ALFF) differences between ALS and control groups without grey matter (GM) correction (A) and with GM correction (B).
Image credit: Luo, et.al. 2012 under CC BY license

Job Opportunities

To submit any new job opportunities for this list, please email ALSjobs@prize4life.org. List the employer, location, closing date if applicable, and a link to more information. Jobs are removed after 3 months, unless requested otherwise.

This free job bulletin board aims to help scientists identify job opportunities in the field of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Positions described as broadly spanning neurodegenerative diseases (NDG) are noted as ‘NDG‘. The job listing includes research positions at all levels, as well as non-research positions for which a research background at the MS, PhD, or MD level is required.


Click the title of any table column to sort.

Academia

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Research Technician

Research Technician

(Click title to open job details in a new window.)
Description:

We are looking for individuals interested in a career in medicine to join our productive clinical research team for a 1-year term limited position (possible extension 1-3 years depending on funding).


Our group focuses on the causes and risk factors of amyotrophic lateral sclerosis (ALS) while also running an active clinical trial program. Individuals that are highly motivated, independent, and work well under pressure are encouraged to apply. Individuals are expected to gain outstanding experience in clinical research including patient interaction, the use of epidemiologic surveys in clinical trials, clinical trial outcomes measures, and clinical trial coordination. Individuals will receive mentoring from 2 medical doctors and an RN involved in the ALS clinic, as well as supervision from a researcher in a medical laboratory. This person will work as part of a dynamic team of clinical and basic scientists.


The core duties of this position are to collect and enter epidemiologic data from research participants, schedule study activities, participate in clinical trial activities, label and collect blood samples from patients.


Please note: In the event that the appointment is not extended, the appointment will terminate and will not be eligible for Reduction in Force (RIF) benefits.


A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest(s) in the position and how this position will help you achieve your long-term career/education goals. Please include 3 references in your cover letter. Applications not meeting the above will not be considered.


Link: http://umich.jobs/ann-arbor-mi/research-laboratory-tech-assoc/A724D18841064885ABF178C203A92FC3/job/?utm_campaign=Michigan%20State%20Job%20Bank&vs=151&utm_medium=NLX&utm_source=Michigan%20State%20Job%20Bank-DE
Employer: University of Michigan
Location: Ann Arbor, MI
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: August 12th, 2017
University of MichiganAnn Arbor, MIBA or BSALSAug 12, 2017
NEW! Assistant, Associate or Full Professor

Assistant, Associate or Full Professor

(Click title to open job details in a new window.)
Description:

The Department of Anatomy and Cell Biology at the University of Illinois at Chicago (UIC) is seeking applications for outstanding candidates for tenure track positions at the Assistant, Associate and Full Professor ranks in the field of Neuroscience. We seek candidates with a record of innovative basic and/or translational Neuroscience research including fundamental questions in cellular and systems neuroscience. Areas of interest include but are not limited to:


*Adult onset neurodegeneration, with an emphasis on Alzheimer’s Parkinson’s, Huntington’s, Amyotrophic Lateral Sclerosis, and Prion diseases

*Neurobiology of white matter disorders

*Biology of acute and chronic neuroinflammation

*Biology and modeling of neuro-injuries

*Role of lipids and membrane processes in homeostasis and cell signaling in the brain


Applicants must be a Ph.D., M.D., or MD/Ph.D. with a strong publication record in leading peer-reviewed journals, and potential for extramural funding at the Assistant Professor rank or current extramural funding at the Associate rank.


To apply, please submit online your package including a CV, research and teaching statements, the names and email addresses of three references at:


https://jobs.uic.edu/job-board/job-details?jobID=83516


The deadline for full consideration is October 31st, 2017, but applicants will be considered until the positions are filled.


Link: https://jobs.uic.edu/job-board/job-details?jobID=83516
Employer: University of Illinois
Location: Chicago, IL
Sector: Academia
Degree required: PhD, MD or PhD/MD
Conditions: ALS
Job posted: August 10th, 2017
Applications close: October 31st, 2017
University of IllinoisChicago, ILPhD, MD or PhD/MDALSAug 10, 2017
NEW! Director, Waisman Center

Director, Waisman Center

(Click title to open job details in a new window.)
Description:

The Waisman Center is dedicated to the advancement of knowledge about human development, developmental disabilities, and neurodegenerative diseases throughout the lifespan. The Center is one of 14 national Intellectual and Developmental Disabilities Research Centers and also encompasses a federally funded University Center for Excellence in Developmental Disabilities. The Waisman Center provides an interdisciplinary research environment for over 50 faculty representing 20 academic departments of the University of Wisconsin-Madison and approximately 600 faculty, staff, graduate students, and postdoctoral fellows. The Waisman Center clinics and support programs serve more than 4,000 people with developmental disabilities a year.


The Director provides scientific and administrative leadership in basic and applied research in the behavioral and biomedical sciences. The Director serves as Principal Investigator for the NIH IDDRC award and is responsible for all aspects of program leadership and management including proposal writing, reporting, compliance, developing an effective management structure and regular communication with NIH leadership.


Minimum of a Ph.D., M.D. or other doctoral degree in a field relevant to developmental disabilities. Candidate must be eligible for tenure at the University of Wisconsin-Madison. The Waisman Director will have a concurrent faculty appointment in an appropriate academic department.


Please see full position listing and application instructions at: http://go.wisc.edu/i8dq3v.


Or contact Kelly Marks at Kelly.marks@wisc.edu or 608-262-5802.


Link: http://go.wisc.edu/i8dq3v
Employer: University of Wisconsin
Location: Madison, WI
Sector: Academia
Degree required: PhD or MD
Conditions: NDG
Job posted: August 8th, 2017
Applications close: October 7th, 2017
University of WisconsinMadison, WIPhD or MDNDGAug 08, 2017
Group Leader, Neurogenomics

Group Leader, Neurogenomics

(Click title to open job details in a new window.)
Description:

Expressions of interest are invited from suitably qualified scientists wishing to develop their scientific research career as Group Leader, Neurogenomics at the Garvan Institute of Medical Research, Sydney, Australia.


The Garvan Institute is seeking top-quality researchers with experience in genetics and genomics to develop independent research laboratories within the Neuroscience Division in the following areas:


*Molecular neuroscience to study brain development and brain function

*Genomic approaches to study neuroplasticity in any system

*Genetic and genomic approaches to study neurological diseases and neurodegenerative diseases


Contract Term: The appointment will be for a period of five (5) years with the possibility of extension for an additional four (4) years.


Commencement Date: Anticipated commencement is early 2018 or as otherwise agreed.


How do I apply?

To apply, please send a cover letter, full curriculum vitae and a concise statement summarising your research interests (current and future) to Dr Marie Dziadek, Garvan Chief Scientific Officer (m.dziadek@garvan.org.au). A Position Description can be obtained from Dr Dziadek. Applications will be accepted until midnight 6 September 2017 Australian Eastern Standard Time.


Link: https://www.nature.com/naturejobs/science/jobs/621279-embl-australia-group-leaders-in-audio-and-neuro-genomics
Employer: EMBL Australia
Location: Sydney, Australia
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: August 7th, 2017
Applications close: September 6th, 2017
EMBL AustraliaSydney, AustraliaPhDNDGAug 07, 2017
Research Associate, Gao Lab

Research Associate, Gao Lab

(Click title to open job details in a new window.)
Description:

A Research Associate position in the laboratory of Dr. Fen-Biao Gao at the Department of Neurology is available to help study frontotemporal dementia using induced pluripotent stem cells (iPSCs). Candidates with substantial research experiences in molecular biology (such as western blot, cloning etc.) and cell biology (such as stem cell culture and differentiation, or mammalian cell cultures in general) are encouraged to apply. Candidates with PhD or MD degrees will be considered as well.


Link: https://careers-umms.icims.com/jobs/29478/research-associate-i/job?%3Fmode=apply&iis=SOURCE&iisn=SOURCENAME&mobile=false&width=920&height=500&bga=true&needsRedirect=false&jan1offset=-300&jun1offset=-240
Employer: University of Massachusetts Medical School
Location: Worcester, MA
Sector: Academia
Degree required: BS
Conditions: FTD
Job posted: August 7th, 2017
University of Massachusetts Medical SchoolWorcester, MABSFTDAug 07, 2017
Postdoctoral Fellow, Gao Lab

Postdoctoral Fellow, Gao Lab

(Click title to open job details in a new window.)
Description:

A postdoctoral position is immediately available in the laboratory of Dr. Fen-Biao Gao at the University of Massachusetts Medical School to study molecular pathogenic mechanisms of fronototemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).


PhD required. Candidates with strong research experience in stem cell biology or molecular and cellular biology are encouraged to apply.


To Apply: Please forward CV to: Fen-Biao.Gao@umassmed.edu.


Link: http://www.nature.com/naturejobs/science/jobs/605061-postdoctoral-position
Employer: University of Massachusetts Medical School
Location: Worcester, MA
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: August 1st, 2017
Applications close: September 30th, 2017
University of Massachusetts Medical SchoolWorcester, MAPhDALS, FTDAug 01, 2017
Chair, Department of Neuroscience

Chair, Department of Neuroscience

(Click title to open job details in a new window.)
Description:

The UConn School of Medicine is seeking an outstanding neuroscientist at a rank of Associate or Full Professor to become Chair of the Department of Neuroscience. Candidates with nationally recognized accomplishments in research, sustained NIH or extramural funding, and leadership experience are encouraged to apply. Desired areas of expertise include but are not limited to cellular and molecular neuroscience, chronic and neurodegenerative diseases, brain circuitry research, and neurogenesis and regeneration. This position is ideal for an energetic individual with the leadership skills and vision required to foster the health and growth of a department that values academic excellence and collaboration. The departmental faculty excel in a variety of research areas

(neuroscience.uchc.edu), lead educational programs in the graduate, medical and dental schools, and provide a stimulating environment for research trainees.


Interested applicants should submit a cover letter indicating research interests, vision for the department and description of leadership style (maximum of 2 pages) with an up to date curriculum vitae in a single pdf file to the UConn Health Employment Services website (Search no. 2017-707)

https://jobs.uchc.edu. Please address questions to the search committee chair, Dr. Anthony Vella c/o Shelly Lombardo (neurosciencechair@uchc.edu). Applications will be accepted and reviewed until the position is filled.


Link: https://jobs.sciencecareers.org/job/458343/chair-department-of-neuroscience/
Employer: University of Connecticut School of Medicine
Location: Farmington, CT
Sector: Academia
Degree required: PhD or MD/PhD
Conditions: NDG
Job posted: July 28th, 2017
University of Connecticut School of MedicineFarmington, CTPhD or MD/PhDNDGJul 28, 2017
Postdoctoral Fellow, Talbot Lab

Postdoctoral Fellow, Talbot Lab

(Click title to open job details in a new window.)
Description:

An exciting opportunity has arisen to work as a Postdoctoral Researcher in Neurodegeneration in the Oxford Motor Neuron Disease Centre based in the John Radcliffe Hospital, Oxford. Working with Professor Kevin Talbot your research will investigate the mechanisms of motor neuron disease in amyotrophic lateral sclerosis using a novel BAC transgenic mouse, based on a mutation in TDP-43. Specifically, we will characterise the contributions of motor neuron-specific and non-cell autonomous effects of mutant TDP 43 on disease onset and progression in the TDP-43M337V BAC transgenic mouse, by inactivating the mutation in neurons or glia respectively, using the Cre-loxP system. Cell co-culture (directly or indirectly through conditioned media) of primary embryonic mouse motor neurons and microglia from these mice, will allow further characterisation of the relative effects of motor neuron-specific or microglial-specific expression of mutant TDP-43 on motor neuron function, morphology and survival, and TDP-43 cytoplasmic mislocalisation.


Your responsibilities and duties will include phenotyping primary neuronal and glial cells in culture, including using immunofluorescence and developing skills in mouse phenotyping, using an established mouse model of ALS based on TDP-43 mutations to validate candidate drugs and adapting existing and developing new scientific techniques and experimental protocols. Your role will also involve you managing your own academic research and administrative activities. This will involve small scale project management, to co-ordinate multiple aspects of work to meet deadlines.


You will have a PhD/DPhil in a relevant discipline or be near to completion with experience of primary neuronal cell culture and a degree in neuroscience or a related subject. You will need to manage your own workload to strict deadlines and work independently as well as contributing to the research activities of the group. Experience of working with glial cultures and mouse models would be advantageous.


Link: http://www.nature.com/naturejobs/science/jobs/620469-postdoctoral-researcher-in-neurodegeneration
Employer: University of Oxford
Location: Oxford, England
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: July 28th, 2017
Applications close: August 28th, 2017
University of OxfordOxford, EnglandPhDALSJul 28, 2017
Associate Professor, Cognitive Neuroscience

Associate Professor, Cognitive Neuroscience

(Click title to open job details in a new window.)
Description:

The Department of Psychiatry & Behavioral Sciences and the Cognitive Neurology and Alzheimer’s Disease Center at the Northwestern University Feinberg School of Medicine are jointly searching for a cognitive neuroscientist. The successful candidate will have the credentials for a full-time tenure-track appointment (Investigator Track) at the level of Associate Professor. The candidate will have the capability to lead an independent laboratory on the experimental neuropsychology and multimodal imaging of neurodegenerative diseases and successful aging. Established track record of research achievements in these areas and expertise on the cognitive aspects of aging and dementia are desirable. The successful candidate will contribute to the academic mission of the Clinical Psychology Doctoral Program within the Department of Psychiatry and will lead his/her research program on dementia and aging within the Cognitive Neurology and Alzheimer’s Disease Center. The start date is negotiable and the position will remain open until filled.


Correspondence Should Be Sent To:

Marsel Mesulam, MD

Northwestern University Feinberg School of Medicine

320 East Superior Street, Searle 11-450

Chicago, IL 60611

Email:mmesulam@northwestern.edu


Website: http://www.brain.northwestern.edu


Link: https://careers.northwestern.edu/psp/hr92prod_er/EMPLOYEE/HRMS/c/HRS_HRAM.HRS_APP_SCHJOB.GBL?Page=HRS_APP_JBPST&Action=U&SiteId=1&FOCUS=Employee&JobOpeningId=30514&PostingSeq=1
Employer: Northwestern University
Location: Chicago, IL
Sector: Academia
Degree required:
Conditions: NDG
Job posted: July 25th, 2017
Northwestern UniversityChicago, ILNDGJul 25, 2017
Director of Neurodegenerative Research

Director of Neurodegenerative Research

(Click title to open job details in a new window.)
Description:

We are currently on the hunt for a Director of Research– Neurodegenerative to oversee all aspects of neurodegenerative gene therapy research at the GTP at PENN. In this role, you will be responsible for build a team of Senior Research Investigators (SRI) to support GTP’s Neurodegenerative research efforts; establishing processes for mentoring and leading SRIs in research projects; directly oversee and manage a team of SRIs and technicians; In consultation with the PI of the GTP, the Research Director – Neurodegenerative will assess the rare disease programs that are brought into GTP for scientific research. The individual should have in-vivo pharmacology expertise for preclinical translational programs as well as expertise in testing the efficacy of therapeutic interventions for neurodegenerative disease indications. Joining GTP offers scientific professionals the unique opportunity of seeing their research go from bench to bedside and discoveries that could one day lead to cures.


As a top candidate for this role, you will possess:


Master’s Degree and 5 years to 7 years of experience or equivalent combination of education and experience required. Ph.D. strongly preferred.

Extensive knowledge of life science research in both academic and biopharmaceutical settings

Self-starter but also a strong desire to contribute and work collaboratively to achieve goals

Success in roles requiring execution of multiple tasks while responding to multiple priorities

Highly functioning, detail-oriented, and analytical candidate who can think strategically

Excellent oral/written communication skills required


Link: https://www.linkedin.com/jobs/view/333064453/
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: July 24th, 2017
University of PennsylvaniaPhiladelphia, PAPhDNDGJul 24, 2017
Graduate Studentship, Basso Lab

Graduate Studentship, Basso Lab

(Click title to open job details in a new window.)
Description:

The major focus of the project is on extracellular vesicles and motor neuron degeneration with a particular interest on the role of RNA in the glia-motoneuronal intercellular communication. The PhD student will acquire expertise on extracellular vesicles analysis, RNA profiling in the field of neurodegeneration.


Link: https://jobs.sciencecareers.org/job/458123/phd-scholarship-rna-mediated-intercellular-miscommunication-role-of-extracellular-vesicle-cargos-/
Employer: University of Trento
Location: Trento, Italy
Sector: Academia
Degree required: MS
Conditions: ALS
Job posted: July 24th, 2017
University of TrentoTrento, ItalyMSALSJul 24, 2017
Graduate Studentship, Maudsley Lab

Graduate Studentship, Maudsley Lab

(Click title to open job details in a new window.)
Description:

The aim of this project is to disentangle the converging molecular pathomechanisms in the frontotemporal dementia – amyotrophic lateral sclerosis spectrum. We will pursue this goal by investigating different mouse models using state-of-the-art proteomic and transcriptomic technologies. Using this approach, we intend to unravel the disease mechanisms already at presymptomatic stages.


Link: https://jobs.sciencecareers.org/job/458084/doctoral-grant-bof-area-of-translational-neurosciences/
Employer: VIB
Location: Antwerp, Belgium
Sector: Academia
Degree required: MS
Conditions: FTD
Job posted: July 24th, 2017
VIBAntwerp, BelgiumMSFTDJul 24, 2017
Assistant, Associate or Professor, Pharmacology

Assistant, Associate or Professor, Pharmacology

(Click title to open job details in a new window.)
Description:

The University of Southern California (USC) Titus Family Department of Clinical Pharmacy invites applications for a tenured/tenure track position at the rank of Assistant, Associate or Professor. Individuals with research interests in pharmacogenomics, pharmacometrics, bioinformatics, or medication safety are encouraged to apply.


We are particularly interested in individuals focused on the application of pharmacogenomics or pharmacometrics to predict the efficacy and safety of medications in the treatment of neurodegenerative, cardiovascular, respiratory or endocrine diseases. Specific areas of research expertise should lead to collaborations with both basic and clinical/practice researchers.


Candidates should have a doctoral degree and postdoctoral experience in pharmacogenomics, pharmacometrics, bioinformatics, or a related discipline. The successful candidate should demonstrate an interest and track record in interdisciplinary and translational research that is directly applicable to problems in patient care. The successful candidate is expected to develop an internationally recognized and an externally funded research program. Excellent teaching and communication skills as well as a strong commitment to professional, graduate and post-doctoral education are essential.


For consideration, please apply online at Jobs@USC, Requisition ID# REQ20044132 @ https://jobs.usc.edu/applicants


Link: https://jobs.sciencecareers.org/job/457753/assistant-associate-or-professor/
Employer: University of Southern California
Location: Los Angeles, CA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: July 21st, 2017
University of Southern CaliforniaLos Angeles, CAPhDNDGJul 21, 2017
Translational Scientist

Translational Scientist

(Click title to open job details in a new window.)
Description:

We sincerely invite applications from outstanding translational scientists who aim to conduct cutting-edge and innovative research. Successful applicants will be offered generous start-up packages and internationally competitive benefits. Positions will remain open until filled.


Requirements


M.D., and/or Ph.D. or equivalent degrees with postdoctoral training or prior faculty experiences in or related to the fields of translational medicine

Demonstrated track record of excellence in areas including but not limited to cancer, immunological diseases, cardiovascular diseases, and neurological diseases;

Applicants from all gender and ethnic groups with citizenships in any nationalities are encouraged to apply. The applications will be evaluated strictly based on scientific merits and translational potentials.

Required documents


Interested individuals are urged to send the following documents to zhoujie128@mail.tsinghua.edu.cn and pumchkyc@126.com with “Translational Medicine Faculty Application” in the subject line:


Cover letter

Curriculum vitae

Statement of research and teaching interests

Names and contact information of three referees who are willing to provide recommendation letters upon requests


Link: https://jobs.sciencecareers.org/job/457011/translational-medicine-investigator-positions-by-tsinghua-university-and-pumch/?LinkSource=PremiumListing
Employer: Tsinghua University School of Medicine
Location: Beijing, China
Sector: Academia
Degree required: MD and/or PhD
Conditions: NDG
Job posted: July 14th, 2017
Tsinghua University School of MedicineBeijing, ChinaMD and/or PhDNDGJul 14, 2017
Assistant, Associate or Full Professor, Environmental Health

Assistant, Associate or Full Professor, Environmental Health

(Click title to open job details in a new window.)
Description:

The Department of Environmental and Occupational Health (EOH) within the Robert Stempel College of Public Health & Social Work (RSCPHSW) at Florida International University (FIU) invites applications for two tenured/tenure-track faculty member at the Assistant/Associate/Professor rank (rank and tenure commensurate with qualifications).


The ideal candidate will be a visionary scientist who studies how the environment influences human health at every level from micro to macro—from the ways that molecules of pollutants alter the genome to the impact of climate change on global patterns of disease. Applicants should have a Ph.D., M.D., or the equivalent in a biomedical related subject.


The successful candidate will have a record of scholarship and demonstrated success in extramurally funded research as well as experience in teaching and mentorship. Proven ability to conduct innovative and/or state-of-the art research is required. The EOH Department is particularly interested in the “exposome”, or research that studies the totality of a person’s environmental exposures across the life span and how it affects human health. The research areas may include internal and external exposures that are not limited to chemical pollutants found in air and water, but also exposures arising from a variety of sources such as the microbiome, infectious agents, nutritional sources, and stress. A second area of increased interest is related to studies on the role of exposure to environmental pollutants across the lifespan on neurological, neurodegenerative and mental disease.


Link: https://www.startwire.com/express_apply_jobs/MjEyNF9lYTZkNTk3NzdkODcwNTc0M2I4NDNhYjVmYTNhY2M5Y19sdXVhX2k=?source=adzuna_l2
Employer: Florida International University
Location: Miami, FL
Sector: Academia
Degree required: PhD or MD
Conditions: NDG
Job posted: July 13th, 2017
Florida International UniversityMiami, FLPhD or MDNDGJul 13, 2017
Assistant Professor, Developmental and Translational Neurobiology

Assistant Professor, Developmental and Translational Neurobiology

(Click title to open job details in a new window.)
Description:

The Virginia Tech Carilion Research Institute (VTCRI) has launched a new center within the institute – the Developmental and Translational Neurobiology Center (DTNC; https://wp.vtc.vt.edu/dtnc/), to expand the institute’s research programs in cellular and molecular neurobiology in healthy development, disease, and trauma. There are currently two open assistant professor faculty positions – one for a neurobiologist studying mechanisms underlying brain development or neurodevelopmental disorders and one for a neurobiologist or neuro-immunologist studying neurodegenerative disease or brain injury. Applicants should have an earned doctorate, have completed postdoctoral training and demonstrated a track record of successful research, publications and either active extramural funding (preferably from NIH) or show distinct promise to obtain such funding. The new faculty will join a collaborative and highly successful group of investigators at the VTCRI with related research interests in a variety of areas of neuroscience. Competitive salary, space and start-up packages will be provided.


Link: https://www.startwire.com/express_apply_jobs/MjEyNF83YzNhNDViZTNiYTU0YjZmNDhlMWMyMmVmMTA4ZTViYl9sdXVhX2k=?source=adzuna_l2
Employer: Virginia Tech
Location: Blacksburg, VA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: July 12th, 2017
Virginia TechBlacksburg, VAPhDNDGJul 12, 2017
Research Associate, Thomsen Lab

Research Associate, Thomsen Lab

(Click title to open job details in a new window.)
Description:

Dr. Gretchen Thomsen’s Laboratory at the Cedars-Sinai Regenerative Medicine Institute is looking for personnel to join our dynamic group. The incumbent should have an interest in the basic science of stem cells and animal research. The laboratory technician will, under the direction of the PI and lab manager, assist in the conduct of research in amyotrophic lateral sclerosis (ALS) and traumatic brain injury (TBI).


Working under direct supervision, the Research Associate I performs a variety of routine experimental protocols and procedures to support the objectives of one or more laboratory research projects in a specific area of research. Assists in general laboratory activities, including maintenance of reagents and stocking of supplies. Files and monitors documents. Keeps accurate and detailed records of experiments and results. Assists in the operation of specialized equipment and machinery. Observes safety standards and procedures. The Research Assistant I will be able to perform routine rodent colony maintenance/observation, perform animal behavior tasks, as well as perform cellular, micro- and molecular biology procedures including, but not limited to DNA/RNA, KR, protein extraction, cell culture, Immunohistochemistry, and staining. This position does not have supervisory responsibilities.


Link: https://www.cedars-sinaimedicalcenter.apply2jobs.com/ProfExt/index.cfm?fuseaction=mExternal.showJob&RID=26548&CurrentPage=39
Employer: Cedars Sinai Medical Center
Location: Los Angeles, CA
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: July 10th, 2017
Cedars Sinai Medical CenterLos Angeles, CABA or BSALSJul 10, 2017
Research Technician

Research Technician

(Click title to open job details in a new window.)
Description:

The laboratory is seeking a motivated individual to join our efforts in exploring disease mechanisms and developing therapeutic strategies for amyotrophic lateral sclerosis and dementia. Under the direction of the Principal Investigator, the research technician will perform laboratory experiments which include DNA and RNA purification, quantitative PCR, gel electrophoresis, Western blots, DNA cloning, immunostaining and preparation of libraries for high throughput sequencing. The incumbent will also be responsible for handling patient samples and genetic testing of neurodegenerative conditions as part of a research project in collaboration with the ALS multidisciplinary clinic. Additional skills include maintenance of cell cultures, ordering necessary reagents to conduct experiments, and participation in joint upkeep of the lab. Experience in mouse handling and surgical procedures is preferred. The candidate will participate to the research activity of the lab and is expected to be fully engaged in the scientific projects, as well as participate to the scientific lab meetings. The individual must pay attention to details, can work independently under minimal supervision, possess good verbal and written communication skills, and work well as part of a team.


Link: https://partners.taleo.net/careersection/ghc/jobdetail.ftl?job=356045
Employer: Massachusetts General Hospital
Location: Charlestown, MA
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: July 9th, 2017
Massachusetts General HospitalCharlestown, MABA or BSALSJul 09, 2017
Neurologist, Rehabilitation Service

Neurologist, Rehabilitation Service

(Click title to open job details in a new window.)
Description:

As a neurologist on the Neurology and Rehabilitation Service at the Oklahoma City Veterans Affairs Health Care System,who subspecializes in rehabilitation. The duties of this position include: supervise residents and students and attend on the neurology inpatient service 2-3 months annually; attend on the rehabilitation inpatient service2-3 months annually; direct the power-mobility clinic; direct the spinal cord injury, spinal cord diseases, multiple sclerosis, and amyotrophic lateral sclerosis clinic; direct the stroke-care program. The applicant must be able toprovidecare and rehabilitation tothe following populations ofveterans: acute neurology patients in all outpatient and outpatient settings including intensive care units and emergency room; spinal cord injury, spinal cord disease, ALS and MS in the Hub and Spoke system of care; disabled patients due to neurological or orthopedic impairments for rehabilitation care on outpatient and inpatient settings. The applicant must be able to provide acute stroke and post-stroke care and supervise neurology stroke fellows who rotate at the VA. The applicant must participate in ongoing CARF accreditations activities for a Comprehensive Integrated Inpatient Rehabilitation Program, and assist in meeting standards forspecial accreditation in Stroke Rehabilitation. The applicant must be able to supervise neurology stroke fellows, neurology residents, other trainees and students who rotate on the Neurology Inpatient and Outpatient Service, and therefore must meet criteria for faculty appointment in Neurology at the University of Oklahoma Health Science Center.


Link: http://neurojobs.sfn.org/jobs/10054911/physician-neurologist
Employer: University of Oklahoma
Location: Oklahoma City, OK
Sector: Academia
Degree required: MD
Conditions: ALS
Job posted: July 7th, 2017
University of OklahomaOklahoma City, OKMDALSJul 07, 2017
Physician-Scientist (Faculty)

Physician-Scientist (Faculty)

(Click title to open job details in a new window.)
Description:

We seek Physician-Scientists with a basic science or translational research focus in adult-onset neurodegenerative diseases including Alzheimer’s, Parkinson’s, ALS or dementia. This position will complement and synergize with ongoing basic, translational and clinical research programs in the CTM and across Temple’s Medical campus. The CTM has state-of-the-art facilities in a new open-concept research building completed in 2012. The Center currently has multi-disciplinary research interests in gene and stem cell therapy, cardiac and neuronal signaling, heart failure, Alzheimer’s disease and mitochondrial pathobiology with research cores supporting imaging, gene therapy/vectors, bioenergetics and surgery/physiology. Interested candidates should have an MD or MD/PhD degree, and a strong academic record. Academic appointment is available at all levels and competitive packages will be offered based on qualifications.


Please send letters of interest and CV’s to:


Walter J. Koch, PhD, Director

Center for Translational Medicine

c/o Michael Lester

Temple University School of Medicine

3500 N Broad Street, MERB 941

Philadelphia PA 19140


Email: Michael.lester@tuhs.temple.edu


Link: https://jobs.sciencecareers.org/job/456348/physician-scientist-faculty-position-translational-medical-research-in-neurodegeneration/
Employer: Temple University
Location: Philadelphia, PA
Sector: Academia
Degree required: MD or MD/PhD
Conditions: ALS
Job posted: July 7th, 2017
Temple UniversityPhiladelphia, PAMD or MD/PhDALSJul 07, 2017
Professor

Professor

(Click title to open job details in a new window.)
Description:

Building on world class expertise in genetics and immunology, the UK DRI at Cardiff University are looking for a dynamic, innovative dedicated individual who will contribute across the UK DRI as well as within the host centre. You will direct an internationally competitive research programme within the UK Dementia Research Institute (UK DRI) relevant to the area of neurodegeneration, with the ultimate aim of improving human health. Drawing on the knowledge and expertise of other colleagues both within and outside of the UK DRI through collaborative inputs and team working. The UK DRI is looking to transform the field of dementias research and welcomes scientists from all disciplines including frontotemporal dementia.


If you would like to join us on this journey we can offer you excellent benefits, a great working environment, and an opportunity to be part of something that really will make a difference to people’s lives.


For informal enquiries please contact Centre Director, Professor Julie Williams: williamsj@cardiff.ac.uk +44(0) 29 2068 8326


Programme funding: £3 million provided over five years

Salary: an appropriate point on the Professorial pay scale


Closing date: 26 January 2018


Link: http://www.cardiff.ac.uk/dementia-research-institute/join-us/uk-dri-professors
Employer: Cardiff University
Location: Cardiff, Wales
Sector: Academia
Degree required: PhD
Conditions: FTD
Job posted: July 6th, 2017
Applications close: September 3rd, 2017
Cardiff UniversityCardiff, WalesPhDFTDJul 06, 2017
Research Study Coordinator

Research Study Coordinator

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Description:

The Division of Neuromuscular Disorders is seeking a Research Support Coordinator to join a very active clinical research program with multiple ongoing research studies. The primary focus of the work will be on investigator-initiated research in the fields of amyotrophic lateral sclerosis (ALS) and myasthenia gravis (MG). The research support coordinator will work closely with clinical research coordinators, data manager, statistician, clinical staff and the Principal Investigator.


Link: https://um.hodesiq.com/job_detail.asp?JobID=5473953
Employer: University of Miami
Location: Miami, Florida
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: July 4th, 2017
University of MiamiMiami, FloridaBA or BSALSJul 04, 2017
Computational Neuroscientist

Computational Neuroscientist

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Description:

The Krembil Research Institute at the University Health Network in Toronto Canada invites applicants to apply for a Scientist position in the area of Computational Neuroscience. The ideal candidate will have a PhD in a relevant field, research expertise and experience in mathematical and computational modeling, and research interests that complement those of the Institute in neurobiology and neurodegeneration. Candidates whose research interests encompasses cellular, micro/macro circuits and/or large scale brain models, and who have collaborative experimental experience are especially encouraged. The successful candidate will have the ability to establish an independent, well-funded program and will be eligible for appointment at the appropriate level within the University of Toronto.


Link: https://www.recruitingsite.com/csbsites/uhncareers/JobDescription.asp?SiteID=10031&JobNumber=805761
Employer: Krembil Research Institute
Location: Toronto, Canada
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: July 1st, 2017
Applications close: August 28th, 2017
Krembil Research InstituteToronto, CanadaPhDNDGJul 01, 2017
Research Associate, ViTAL Consortium

Research Associate, ViTAL Consortium

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Description:

The postholder will join the ViTAL consortium of researchers working on Amyotrophic Lateral Sclerosis (ALS), funded by the charity TARGET-ALS. They will identify toxic elements that are secreted through exosomes in ALS, and determine their role in ALS. (Fixed-term until 30 June 2018)


We prefer to issue and receive applications via our on-line recruitment website at www.ulster.ac.uk/jobs


Hard copy applications can be obtained by telephoning 028 7012 4072


Link: http://www.nature.com/naturejobs/science/jobs/618061-research-associate-in-als-disease
Employer: University of Ulster
Location: Belfast, Ireland
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: June 26th, 2017
University of UlsterBelfast, IrelandBA or BSALSJun 26, 2017
Research Scientist

Research Scientist

(Click title to open job details in a new window.)
Description:

The Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco (UCSF) is seeking a molecular/cell biologist to design, develop and validate novel tools for the study of neurodegenerative diseases. The director of the IND is Nobel Laureate Dr. Stanley Prusiner.


The successful candidate will have a strong track record in neuroscience research and will join a multi-disciplinary team of scientists dedicated to finding a cure for neurodegenerative diseases by discovering small molecule drugs that prevent the propagation of misfolded proteins in cells, animal models, and eventually, human patients. The team is engaged in fundamental research to understand the process of protein misfolding as well as translational research to apply this knowledge toward drug discovery assays. The candidate should have strong practical experience in protein expression and cell culture. He or she should have excellent management and communication skills and work well in a team environment.


QUALIFICATIONS


Ph.D. with emphasis in neuroscience or neuropharmacology

At least 3 years of post-Ph.D. experience in both molecular and cell biology, including:

DNA cloning and the construction of expression vectors

Transfection and viral infection

Western blotting, immunoprecipitation and protein purification

Cell line differentiation

Stable transfection and cloning

Candidates with experience in cell-based assay development and/or cellular models of neurodegenerative diseases are strongly encouraged to apply

Applicants should possess excellent managerial, leadership, organizational, communication, and interpersonal skills, as well as exhibit evidence of imagination in problem solving.

Preference will be given to candidates with a demonstrated superb command of oral and written English.

This is a full-time position with excellent benefits. Salary is dependent upon experience. Rank will be commensurate with background, experience, and work history.


Interested applicants should submit curriculum vitae with a list of publications, a brief statement of research accomplishments and interests, and contact information for three professional references.


Please apply online at https://aprecruit.ucsf.edu/apply/JPF01324


Link: https://aprecruit.ucsf.edu/apply/JPF01324
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: June 23rd, 2017
University of CaliforniaSan Francisco, CAPhDNDGJun 23, 2017
Postdoctoral Fellow, Neurotherapeutics

Postdoctoral Fellow, Neurotherapeutics

(Click title to open job details in a new window.)
Description:

The research at the Division of Protein Technology is to a large extent focused on development of affinity proteins, including design and engineering of new functions and properties. Affinity protein development is a growing research discipline worldwide with applications in several fields such as biotech and medicine. The group of Biotherapy and Bacterial display has wide experience in combinatorial protein engineering of affinity proteins and has developed methods for such purposes exploiting both phage and bacteria.


The group is currently coordinating projects for development of new protein-based drug candidates targeting proteins and peptides involved in various neurological disorders, such as Frontotemporal Degeneration, Alzheimer’s and Parkinson’s diseases. For these projects, a post-doc position is open. The vacancy center on combinatorial protein engineering technologies, i.e. expression of large collections of protein variants on microorganisms and selection of candidates with desired properties from such collections. It will include exploiting and developing such technologies for generation and investigation of new protein-based reagents to generate affinity-based drug candidates. In line with KTH’s equal opportunity policy, we strongly encourage qualified female and minority candidates to apply.


Qualifications

The candidate should hold a PhD and an analytical/technical interest in molecular biotechnology and/or protein chemistry. Documented experience in protein engineering methodology, such as phage/yeast/bacterial display for generation of proteins with improved properties, is required. Theoretical knowledge of combinatorial protein engineering, including protein library design, is considered a distinct advantage. Experience with FACS, cell assays, recombinant protein production and purification (including affinity chromatography and HPLC) as well as biosensor assays (e.g. SPR-based), is also important.


Employment

Form of employment: Full-time and time-limited. One year, renewable one year.

Start date: As soon as possible

Salary: Salary follows the guidelines provided by KTH


Application

More information about how to apply can be found at https://www.kth.se/en/om/work-at-kth/lediga-jobb/what:job/jobID:158504/where:4/


Link: https://www.kth.se/en/om/work-at-kth/lediga-jobb/what:job/jobID:158504/where:4/
Employer: KTH Royal Institute of Technology
Location: Stockholm, Sweden
Sector: Academia
Degree required: PhD
Conditions: FTD
Job posted: June 22nd, 2017
Applications close: August 22nd, 2017
KTH Royal Institute of TechnologyStockholm, SwedenPhDFTDJun 22, 2017
Postdoctoral Fellow, Sareen Lab

Postdoctoral Fellow, Sareen Lab

(Click title to open job details in a new window.)
Description:

Dr, Dhruv Sareen’s independent research laboratory at the Cedars-Sinai Medical Center, Regenerative Medicine Institute focuses on using human iPSC technology to understand the molecular mechanisms underlying neurodevelopmental/degenerative diseases and how obesity is linked to the brain. His laboratory is particularly interested ‘disease-in-a-dish’ modeling for neuromuscular, neurodegenrative and motor neuron diseases including, amyotrophic lateral sclerosis (ALS). They are particularly interested in C9orF72 and other genetic forms of ALS and what are the common elements with sporadic forms of ALS. Using the iPSC platform his lab has developed novel methods for drug screening on patient motoneurons and dissecting mechanisms for motoneuron degeneration. In the context of stem cell modeling of neurodevelopmental (SMA) and neurodegenerative diseases (ALS) Dr. Sareen’s group is particularly interested in the mechanistic insights how specific neural cell types degenerate during the disease processes. They are using OMICS (proteome, transciptome, metabolome) and imaging methodologies to gain mechanistic insights into the mitochondrial and endorplasmic reticulum stress involvement. In addition, by understanding how the cells of the nervous system develop and differentiate we will be able to develop better and safer cells for transplantation and regenerative therapies. Dr. Sareen’s group has extensive experience in pluripotent and neural stem cell research. He has developed and directed a well-renowned human iPS cell core. He has published high-profile manuscripts on human iPSC-based disease modeling in SMA and ALS.


Dr. Sareen’s laboratory is searching for a highly-capable Post-doctoral Researcher to join his research group to investigate disease mechanisms in neurodegenerative diseases, especially motor neuron disorders. The incumbent should have experience in in neurobiology, biochemistry, molecular biology and stem cells, including analyzing their genetic and biochemical profiles by OMICS technologies. Bioinformatics (programming in R) knowledge is a plus. By using human iPS cell technology and differentiating into different brain cells as well as other tissues of the body we will investigate brain-linked disease mechanisms to develop assays in patient-derived enural cell types and screen for novel therapeutics. Working independently but in close cooperation and in consultation with the PI and other Research Scientists at RMI, the Post-doctoral Researcher will perform routine and complex laboratory procedures throughout. The Post-doctoral Researcher will be expected to assist the PI in preparation of multiple grant proposals and submission of such proposals. They will also prepare full manuscripts for publication as primary first and co-authors. The researcher will be expected to assist the PI in maintaining institutional IRB/SCRO protocols as well as develop new animal and IACUC protocols. The incumbent will develop, adapt, and implement new research techniques and protocols and will analyze and interpret data. They will participate in presentations as author or co-author on scientific meeting abstracts.

Under the direction of Dr. Sareen (PI) the incumbent will help us achieve our research goals by performing the principal duty of using pluripotent and neural stem cell culture techniques to generate neuronal and other tissue differentiation protocols, characterization of the differentiated cells (control vs disease) using techniques such as gene and protein expression, physiological, and phenotypic assessments. The candidate will also be expected to develop and perform differentiation protocols to direct pluripotent stem cells to endoderm, ectoderm and mesoderm lineages. The successful candidate will be responsible for all cell maintenance, expansion and genetic modification using viral vectors or other gene-editing methods. Therefore, experience in stem cell and neurobiology, knowledge of pluripotent/neural cell markers combined with a proven record in stem cell culture techniques is essential. Experience with bioinformatics analysis of RNA-seq and mass spec proteomics data are important. Prior experience in novel genome-editing technologies (CRISPR/Cas9) using pluripotent stem cells is a great asset. Prior experience in high-content compound screening/imaging techniques, handling of the Molecular Devices Image Express Micro system, and a Mass Spectrometer with data analysis are preferred traits. Proficiency in computer algorithm development for automating image-based analysis is also a desirable trait.


Link: https://www.cedars-sinaimedicalcenter.apply2jobs.com/ProfExt/index.cfm?fuseaction=mExternal.showJob&RID=26507&CurrentPage=33
Employer: Cedar Sinai Medical Center
Location: Los Angeles, CA
Sector: Academia
Degree required: MD, PhD, VMD, or DDS
Conditions: ALS
Job posted: June 22nd, 2017
Cedar Sinai Medical CenterLos Angeles, CAMD, PhD, VMD, or DDSALSJun 22, 2017
Research Associate

Research Associate

(Click title to open job details in a new window.)
Description:

Under the supervision of the Principal Investigator, the Staff Research Associate II (SRA II) will assist in the performance of behavioral testing and in the analysis of behavioral and neuroimaging data to support research on the neural bases of decision-making in healthy individuals with a family history of frontotemporal dementia. Specific techniques utilized in these studies will include online computer-based testing, task-based functional MRI, psychophysiology, voxel-based morphometry, functional connectivity, and computational modeling of behavior.


Responsibilities will include assistance in delivering online task-based behavioral assessments, in conducting behavioral/fMRI/psychophysiological testing with research subjects, performing image preprocessing and supervised analyses, managing and reporting on study results, overseeing study data integrity, and reporting study progress to the research team. The position represents an excellent opportunity to further develop research skills and learn basic principles of clinical and cognitive neuroscience.


Link: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?partnerid=6495&siteid=5226&jobId=2511562
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: BA or BS
Conditions: FTD
Job posted: June 22nd, 2017
University of CaliforniaSan Francisco, CABA or BSFTDJun 22, 2017
Graduate Studentship, Vande Velde Lab

Graduate Studentship, Vande Velde Lab

(Click title to open job details in a new window.)
Description:

Dr. Christine Vande Velde is looking to recruit a graduate student to her laboratory located at the CRCHUM facility, a research center affiliated with the Université de Montréal and located in Downtown Montreal.


Our lab is focused on understanding the molecular pathways that contribute to motor neuron degeneration in amyotrophic lateral sclerosis (ALS; also known as Lou Gehrig’s disease and Maladie de Charcot). Techniques include molecular biology, biochemistry, cell biology, and microscopy. We use both tissue culture and transgenic rodent models of disease. Projects include characterizing the role of TDP-43 in RNA granule dynamics, defining pathogenic mechanisms induced by misfolded SOD1, and exploration on hnRNP A1 in ALS biology. We are a young dynamic and bilingual team and we would like to add highly motivated individuals to the current crew. Salary will be based on institutional/CIHR guidelines.


Please submit your CV, your transcripts, and the names and contact information of three referees to c.vande.velde@umontreal.ca. Potential candidates will be contacted for an interview.


Selected Papers


K.K. McDonald, A. Aulas, L. Destroismaisons, S. Pickles, E. Beleac, W. Camu, G.A. Rouleau, and C. Vande Velde. (2011). TAR DNA-Binding Protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1. Human Molecular Genetics 20:1400-1410.


C. Vande Velde*, K.K. McDonald, Y. Boukhedimi, M. McAlonis-Downes, C.S. Lobsiger, S. Bel Hadj, A.N. Zandona, J.P. Julien, S.B. Shah and D.W. Cleveland*. (2011). Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset. PLoS One 6:e22031. *co-corresponding author.


S. Pickles and C. Vande Velde. (2012) Misfolded SOD1 and ALS: Zeroing in on mitochondria. Amyotrophic Lateral Sclerosis 13: 333-340. (invited review).


A. Aulas, S. Stabile and C. Vande Velde. (2012). Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP. Molecular Neurodegeneration 7:54.


S. Pickles, L. Destroismaisons, S.L. Peyrard, S. Cadot, R.H. Brown Jr, G.A. Rouleau, J.P. Julien, N. Arbour and C. Vande Velde. (2013). Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1. Human Molecular Genetics 22: 3947- 3959.


A. Aulas, G. Caron, C.G. Gkogkas, N.-V. Mohamed, L. Destroismaisons, N. Sonenberg, N. Leclerc, J.A. Parker, and C. Vande Velde. (2015). G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA. Journal of Cell Biology 209: 73-84.


Employer: CRCHUM
Principal investigator: Université de Montréal
Location: Montréal, Canada
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: June 20th, 2017
CRCHUMMontréal, CanadaBA or BSALSJun 20, 2017
Postdoctoral Fellow, Vande Velde Lab

Postdoctoral Fellow, Vande Velde Lab

(Click title to open job details in a new window.)
Description:

Dr. Christine Vande Velde is looking to recruit a PostDoc to her laboratory located at the CRCHUM facility, a research center affiliated with the Université de Montréal and located in Downtown Montreal.


Our lab is focused on understanding the molecular pathways that contribute to motor neuron degeneration in amyotrophic lateral sclerosis (ALS; also known as Lou Gehrig’s disease and Maladie de Charcot). Techniques include molecular biology, biochemistry, cell biology, and microscopy. We use both tissue culture and transgenic rodent models of disease. Projects include characterizing the role of TDP-43 in RNA granule dynamics, defining pathogenic mechanisms induced by misfolded SOD1, and exploration on hnRNP A1 in ALS biology. We are a young dynamic and bilingual team and we would like to add highly motivated individuals to the current crew. Salary will be based on institutional/CIHR guidelines.


Please submit your CV, your transcripts, and the names and contact information of three referees to c.vande.velde@umontreal.ca. Potential candidates will be contacted for an interview.


Selected Papers


K.K. McDonald, A. Aulas, L. Destroismaisons, S. Pickles, E. Beleac, W. Camu, G.A. Rouleau, and C. Vande Velde. (2011). TAR DNA-Binding Protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1. Human Molecular Genetics 20:1400-1410.


C. Vande Velde*, K.K. McDonald, Y. Boukhedimi, M. McAlonis-Downes, C.S. Lobsiger, S. Bel Hadj, A.N. Zandona, J.P. Julien, S.B. Shah and D.W. Cleveland*. (2011). Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset. PLoS One 6:e22031. *co-corresponding author.


S. Pickles and C. Vande Velde. (2012) Misfolded SOD1 and ALS: Zeroing in on mitochondria. Amyotrophic Lateral Sclerosis 13: 333-340. (invited review).


A. Aulas, S. Stabile and C. Vande Velde. (2012). Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP. Molecular Neurodegeneration 7:54.


S. Pickles, L. Destroismaisons, S.L. Peyrard, S. Cadot, R.H. Brown Jr, G.A. Rouleau, J.P. Julien, N. Arbour and C. Vande Velde. (2013). Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1. Human Molecular Genetics 22: 3947- 3959.


A. Aulas, G. Caron, C.G. Gkogkas, N.-V. Mohamed, L. Destroismaisons, N. Sonenberg, N. Leclerc, J.A. Parker, and C. Vande Velde. (2015). G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA. Journal of Cell Biology 209: 73-84.


Employer: CRCHUM
Principal investigator: Université de Montréal
Location: Montréal, Canada
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: June 20th, 2017
CRCHUMMontréal, CanadaPhDALSJun 20, 2017
Director, Institute of Biotechnology

Director, Institute of Biotechnology

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Description:

Helsinki Institute of Life Science HiLIFE of the University of Helsinki is seeking a Director of the Institute of Biotechnology (bi.helsinki.fi). The Institute of Biotechnology (BI) is at the forefront of molecular biology research with eight current ERC grantees, and has a strong focus in biotechnology through developing new strategies e.g. to combat neurodegenerative and metabolic diseases. Current research programs at the BI are in Cell and Molecular Biology, Developmental Biology, Genome Biology, and Structural Biology and Biophysics. BI is an international, competitive and rewarding workplace, where the staff within the 25 research groups and 7 core facilities exceeds 250 and comes from 30 different countries. As of 2017 the Institute of Biotechnology is a unit of HiLIFE (www.helsinki.fi/hilife) and collaborates locally across life science units and organizations.


Expectations and conditions

Qualified candidates will be visionary scientific leaders of international stature and with a strong track record of innovative research in relevant areas, and with merits in building interdisciplinary academic research in a highly collaborative environment.


The Institute of Biotechnology Director will

• Be responsible for development of the institute, including producing and implementing a vision for future scientific growth as well as the recruitment of a new generation of outstanding and highly interactive researchers

• Lead her/his own research group

• Foster new collaborations including ones at the University of Helsinki and HiLIFE


The anticipated start date is January 2018 or earlier. The position is initially for five years with a possibility of renewal, and associated with funding for the group and a startup package when appropriate. The salary is negotiable within the salary system of Finnish universities.


Qualifications and experience

The successful candidate will

• Hold an appropriate doctoral degree

• Have an outstanding record of scientific discoveries and success in obtaining funding

• Present a clear vision of future directions in relevant research areas

• Demonstrate successful leadership of international and diverse teams

• Show a commitment to fostering excellence in scientific research and research training


Application deadline, inquiries and nominations

Applications are welcome until August 14, 2017. For further information or proposals for nominations please contact HiLIFE Director Tomi Mäkelä by email hilife-recruit@helsinki.fi or by phone +358 2941 25500.


Submission of applications

Applications are submitted to hilife-recruit@helsinki.fi as a single pdf file with

i) your vision for the development of the Institute of Biotechnology;

ii) your research plan (max 5 pages);

iii) your CV (max 4 pages including biosketch);

iv) a list of not more than 10 selected publications with motivation for selecting each;

v) a link or reference (e.g. ORCID) to a complete list of publications.


Link: http://www.nature.com/naturejobs/science/jobs/617619-director-of-the-institute-of-biotechnology
Employer: University of Helsinki
Location: Helsinki, Finland
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: June 17th, 2017
University of HelsinkiHelsinki, FinlandPhDNDGJun 17, 2017

Industry

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Scientist I, ALS

Scientist I, ALS

(Click title to open job details in a new window.)
Description:

Neurology Research at Biogen seeks a highly motivated and experienced associate scientist to join the new initiative on ALS (amyotrophic lateral sclerosis). The Neurology department is responsible for discovery research on pathogenic mechanisms of neurodegenerative disorders and translating these findings into novel strategies for therapeutic intervention. The successful candidate will execute in vivo experiments to support the validation of novel drug targets and the development of small- and large-molecule drugs for the treatment of ALS. A major component of this work will be the assessment of drug candidates in a multiple rodent models, using a wide variety of morphological and functional endpoints, working closely with members of the ALS team as well as multiple internal and external collaborators. You will work in a fast paced, highly collaborative team environment at an exciting period for ALS research.


Qualifications

•Familiarity with genetic models of neurodegenerative diseases and experience with conducting either pharmacological or genetic tests in those models


•Must demonstrate a keen knowledge of experimental design, underlying scientific principles, and the ability to rigorously analyze and assess results and generate clear reports


•Previous experience handling animals is required and should include some of the following: dosing, dissection, and/or surgery


•Experience in histopathological techniques, such as perfusion, cryostat sectioning, immunostaining is strongly preferred


•Experience in molecular biology and biochemical techniques, such as DNA cloning, electrophoresis, and PCR is preferred


•Experience with behavioral or electrophysiological endpoints would be a positive addition


•Excellent communication and organizational skills are critical.


Link: https://jobs.biogen.com/job/Cambridge-Scientist-I%2C-ALS%2C-Neurodegeneration-and-Repair-MA-02138/418016000/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: ALS
Job posted: August 12th, 2017
BiogenCambridge, MAPhDALSAug 12, 2017
Associate Scientist II, ALS

Associate Scientist II, ALS

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Description:

The Department of Neurology Research is seeking a highly talented and enthusiastic associate to join an in vitro / in vivo target discovery and validation effort in Amyotrophic Lateral Sclerosis (ALS) aimed at bringing new targets and therapeutic strategies from discovery to development. The successful candidate will be expected to support efforts to develop and validate new in vitro ALS models for candidate identification and validate findings in primary mouse tissue.


The successful candidate must have a MS in the Biological Sciences, and will be charged with developing high content assays that will be used to validate genes and pathways identified in genetic screens that affect neurodegeneration. The ideal candidate will have previous experience using cell based methods to investigate neurodegeneration. Experience with biochemical analytical methods such as gel electrophoresis, Western blot, ELISA-type assays, qRT-PCR, as well as immunohistochemistry and immunofluorescence on cells and tissues is important. The candidate will also need experience using AAV or lenti viral transduction approaches as well as experience with RNAi technologies. It is strongly desirable that the candidate has experience basic mouse handling experience with basic surgical techniques. Very strong communication skills are critical for the position as is the ability to work effectively in a highly collaborative research environment.


Link: https://jobs.biogen.com/job/Cambridge-Associate-Scientist-II%2C-ALS-Target-Validation-Research-MA-02138/400261100/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: MS
Conditions: ALS
Job posted: July 31st, 2017
BiogenCambridge, MAMSALSJul 31, 2017
Sr. Clinical Scientist

Sr. Clinical Scientist

(Click title to open job details in a new window.)
Description:

The Sr. Clinical Scientist will work with the Medical Director functions of Early Clinical Development teams and provide scientific and clinical input into early stage clinical development programs. This role will work on cross-functional study teams for the design, execution, and monitoring of clinical trials, early clinical research studies, and/or external research projects, as well as assist with data interpretation and communication.. This individual will report directly into a Sr. Medical Director of Clinical Development or a Therapeutic Area VP and will interface directly with other functions including Clinical Development, Clinical Pharmacology, and Biomarkers.


Link: https://jobs.biogen.com/job/Cambridge-Sr_-Clinical-Scientis%2C-Neurodegeneration-and-Repair-Research-Unit-MA-02138/421188900/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD or PharmD
Conditions: NDG
Job posted: July 31st, 2017
BiogenCambridge, MAPhD or PharmDNDGJul 31, 2017
Director/Sr. Director, Neurodegeneration and Repair Research

Director/Sr. Director, Neurodegeneration and Repair Research

(Click title to open job details in a new window.)
Description:

We are looking for a talented leader to direct preclinical research in Dementia and Memory Disorders within the new Neurodegeneration and Repair Research Unit. In close partnership with the early clinical lead for within the same unit, the successful candidate will be responsible for delivering innovative drug candidates for proof-of-concept trials in AD, FTD and other memory disorders. He/she will lead the efforts of multiple research teams from early target discovery to late preclinical development and support the clinical trial strategy. We seek a candidate with knowledge of the biology of neurodegeneration and an outstanding track record in the field of drug development. He/she will succeed by collaborating closely with other Biogen scientists and clinicians in the areas of neurodegeneration, neuroimmunology and repair, as well as experts in the multiple therapeutic modalities – small molecules, antibodies, biologics, antisense oligonucleotides and gene therapy – in the Biogen portfolio. An innovative approach to biomarker and drug delivery strategies will also be required. We particularly seek candidates who have demonstrated strong scientific rigor while exploring novel pathways and mechanisms in humans and model systems and in leading multidisciplinary research teams. Demonstrated expertise in Alzheimer’s research and experimental models would be an advantage but is not required.


Link: https://jobs.biogen.com/job/Cambridge-DirectorSr_Director%2C-Neurodegeneration-and-Repair-Research-MA-02138/374546100/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD or PhD/MD
Conditions: FTD
Job posted: July 28th, 2017
BiogenCambridge, MAPhD or PhD/MDFTDJul 28, 2017
Scientist

Scientist

(Click title to open job details in a new window.)
Description:

As Scientist and critical member of the committed Neuro-Immunology team, you’ll help Alector discover and develop novel drugs targeting dementia and other neurological disorders. You will design and prioritize your own experiments and research endeavors to further Alector’s collective scientific understanding. In doing so you’ll apply your scientific insights to grow the company and guide its direction. Your work will be both inside and outside of the lab, and both strategic and hands-on. As an early hire, you’ll be influential in championing and developing Alector’s culture.


During The First Year, Your Goals Will Include:

*Independently leading a high-priority target discovery project from-end-to-end, from high-level design and planning to running experiments, assessing results and identifying the critical path forward to a fast go/no-go decision within a year of project start

*Being a great partner to both academic collaborators and contract research organizations to ensure successful joint efforts

*Collaborating within and across teams, including mentoring others on your areas of expertise so that they can learn from your relevant extraordinary skills

*Analyzing current scientific literature to help identify new targets or new strategies for existing targets

*Supporting ongoing projects based on your scientific knowledge and skills


We’d love to hear from you if:

*You enjoy finding creative and novel ways of thinking through scientific questions, and are an extraordinary critical thinker

*You take pride in being persistent, self-motivated, hands-on, and scrappy

*You demonstrate a track record of proficiency across a variety of techniques and instruments to seek answers to your scientific questions

*You have experience in several of: molecular biology, biochemistry, ELISA, flow cytometry, or in vivo mouse genetics

*Your academic background includes a PhD with 3+ years of postdoc research in a premier research lab (in neurobiology, neuroscience, neuro-immunology) or PhD+ 2 years of work in an industry setting

*You thrive in an environment where we work independently and on team

*You have strong points of view but are low ego

*Prior experience working with mouse models of neuro-degeneration and/or antibody discovery is a bonus.


Link: https://workable.com/j/C930FBE1A3
Employer: Alector
Location: San Francisco, CA
Sector: Industry
Degree required: PhD
Conditions: ALS, FTD
Job posted: July 10th, 2017
AlectorSan Francisco, CAPhDALS, FTDJul 10, 2017
Director of Clinical Operations

Director of Clinical Operations

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Description:

At Alector, we believe that neurodegeneration and dementia, are in fact immune disorders and we made it our mission to empower the immune system to cure Alzheimer’s disease, frontotemporal dementia, ALS and other degenerative brain conditions. We are supported by leading investors in healthcare including Orbimed, Polaris, Google Ventures and count some of the most innovative pharma companies as our strategic backers.


Use your hard-earned clinical and operational skills to help us achieve our exciting and important mission of saving lives by curing neurodegenerative diseases. As the Head of Clinical Operations (reporting to the Chief Medical Officer), you’ll lead the building of Alector’s clinical development operations capability. You will oversee all aspects of defining the clinical operations strategy, as well as successfully planning, executing, analyzing, and reporting on all of Alector’s clinical programs. You’ll be ensuring that these programs and goals are delivered on time, within budget and in compliance with Good Clinical Practices and laws and regulations. Over time, you will build a high-performing team of clinical professionals. You’ll be both strategic and hands-on, collaborating across Medical, Research, Development Science, CMC, and Finance teams to implement the Company’s clinical strategies and drive organizational success. As an early hire, you’ll be influential in championing and developing Alector’s culture.


Link: https://workable.com/j/16FC98B9EC
Employer: Alector
Location: San Francisco, CA
Sector: Industry
Degree required: MS; MBA preferred
Conditions: ALS, FTD
Job posted: July 1st, 2017
AlectorSan Francisco, CAMS; MBA preferredALS, FTDJul 01, 2017
Postdoctoral Fellow

Postdoctoral Fellow

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Description:

Sanofi’s Neuroscience Research Therapeutic Area based in Framingham, MA is looking for a highly qualified and motivated Postdoctoral Scientist to investigate the underlying disease biology of amyotrophic lateral sclerosis (ALS). The successful candidate will implement manifold in vitro and in vivo experimental approaches to help identify and validate innovative therapeutic targets for the treatment of ALS. These techniques include molecular biology, biochemistry, cell culture, immunoblotting, immunohistochemistry, microscopy, laser capture microdissection and the use of transgenic mouse models.


Responsibilities


Design and execute experimental strategies to understand the manner in which TDP-43 mislocalization contributes to ALS disease pathogenesis

Establish in vitro cell based models (astrocytes and motor neurons) of ALS

Conduct in vivo experimental work (clinical scoring, motor testing and tissue collection) using transgenic mouse models of ALS

Implementation of multiple state-of-the-art techniques in molecular biology, biochemistry, and microscopy

Analyze, interpret, and present experimental results at lab meetings.

Publish/present findings in peer-reviewed journals/scientific conferences.

Maintain accurate records of experiments and analyses.

Maintain lucid and effective communication with manager and other colleagues.


Basic Qualifications:


Ph.D. in Neuroscience or related field, with at 0-3 years of postdoctoral training

Previous first-author publication(s) in internationally recognized journals are required

Ability to meet aggressive timelines and deliverables in a collaborative environment

Excellent speaking, reading and writing skills

Strong analytical and organizational skills

Curiosity and a willingness to work independently

All candidates must have authorization to work in the United States throughout the duration of the Fellowship. No visa sponsorship will be provided


Link: https://jobs.sanofi.us/job/framingham/postdoctoral-fellowship-neuroscience-research/18104/4949481
Employer: Sanofi
Location: Framingham, MA
Sector: Industry
Degree required: PhD
Conditions: ALS
Job posted: June 21st, 2017
SanofiFramingham, MAPhDALSJun 21, 2017
Senior Associate Scientist, ALS and PD

Senior Associate Scientist, ALS and PD

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Description:

We are seeking a Research Senior Associate Scientist to join a vibrant and growing group currently focusing on Neurodegenerative diseases within the Neuroscience Therapeutic Area, a key component of the Discovery Research unit at Amgen’s site in Cambridge, MA (Amgen MAssachusetts-AMA). The successful candidate must be highly motivated with a deep interest in developing new and effective therapeutics for Parkinson’s disease (PD)/ALS.


Position Responsibilities

Conduct biochemical and cell-based experiments/assays to evaluate novel mechanisms and interrogate the biology of new therapeutic targets for PD/ALS

Carry out experiments required to rigorously evaluate in-licensing opportunities

Critically analyze and interpret data, and meet delivery deadlines

Work closely with and communicate results to multi-disciplinary and cross-functional teams

Execute high impact studies within an extremely fast-paced and collaborative environment


Link: https://careers.amgen.com/job/7265433/sr-associate-scientist-parkinsons-disease-als-cambridge-ma/
Employer: Amgen
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: ALS
Job posted: June 20th, 2017
AmgenCambridge, MABS or MSALSJun 20, 2017

Non-Profit and Government

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