Figure 1B Amplitude of low frequency fluctuation  (ALFF) differences between ALS and control groups without grey matter (GM) correction (A) and with GM correction (B).
Image credit: Luo, et.al. 2012 under CC BY license

Job Opportunities

To submit any new job opportunities for this list, please email ALSjobs@prize4life.org. List the employer, location, closing date if applicable, and a link to more information. Jobs are removed after 3 months, unless requested otherwise.

This free job bulletin board aims to help scientists identify job opportunities in the field of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Positions described as broadly spanning neurodegenerative diseases (NDG) are noted as ‘NDG‘. The job listing includes research positions at all levels, as well as non-research positions for which a research background at the MS, PhD, or MD level is required.


Click the title of any table column to sort.

Academia

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Director of Neurodegenerative Research

Director of Neurodegenerative Research

(Click title to open job details in a new window.)
Description:

We are currently on the hunt for a Director of Research– Neurodegenerative to oversee all aspects of neurodegenerative gene therapy research at the GTP at PENN. In this role, you will be responsible for build a team of Senior Research Investigators (SRI) to support GTP’s Neurodegenerative research efforts; establishing processes for mentoring and leading SRIs in research projects; directly oversee and manage a team of SRIs and technicians; In consultation with the PI of the GTP, the Research Director – Neurodegenerative will assess the rare disease programs that are brought into GTP for scientific research. The individual should have in-vivo pharmacology expertise for preclinical translational programs as well as expertise in testing the efficacy of therapeutic interventions for neurodegenerative disease indications. Joining GTP offers scientific professionals the unique opportunity of seeing their research go from bench to bedside and discoveries that could one day lead to cures.


As a top candidate for this role, you will possess:


Master’s Degree and 5 years to 7 years of experience or equivalent combination of education and experience required. Ph.D. strongly preferred.

Extensive knowledge of life science research in both academic and biopharmaceutical settings

Self-starter but also a strong desire to contribute and work collaboratively to achieve goals

Success in roles requiring execution of multiple tasks while responding to multiple priorities

Highly functioning, detail-oriented, and analytical candidate who can think strategically

Excellent oral/written communication skills required


Link: https://www.linkedin.com/jobs/view/333064453/
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: July 24th, 2017
University of PennsylvaniaPhiladelphia, PAPhDNDGJul 24, 2017
NEW! Graduate Studentship, Basso Lab

Graduate Studentship, Basso Lab

(Click title to open job details in a new window.)
Description:

The major focus of the project is on extracellular vesicles and motor neuron degeneration with a particular interest on the role of RNA in the glia-motoneuronal intercellular communication. The PhD student will acquire expertise on extracellular vesicles analysis, RNA profiling in the field of neurodegeneration.


Link: https://jobs.sciencecareers.org/job/458123/phd-scholarship-rna-mediated-intercellular-miscommunication-role-of-extracellular-vesicle-cargos-/
Employer: University of Trento
Location: Trento, Italy
Sector: Academia
Degree required: MS
Conditions: ALS
Job posted: July 24th, 2017
University of TrentoTrento, ItalyMSALSJul 24, 2017
NEW! Assistant, Associate or Professor, Pharmacology

Assistant, Associate or Professor, Pharmacology

(Click title to open job details in a new window.)
Description:

The University of Southern California (USC) Titus Family Department of Clinical Pharmacy invites applications for a tenured/tenure track position at the rank of Assistant, Associate or Professor. Individuals with research interests in pharmacogenomics, pharmacometrics, bioinformatics, or medication safety are encouraged to apply.


We are particularly interested in individuals focused on the application of pharmacogenomics or pharmacometrics to predict the efficacy and safety of medications in the treatment of neurodegenerative, cardiovascular, respiratory or endocrine diseases. Specific areas of research expertise should lead to collaborations with both basic and clinical/practice researchers.


Candidates should have a doctoral degree and postdoctoral experience in pharmacogenomics, pharmacometrics, bioinformatics, or a related discipline. The successful candidate should demonstrate an interest and track record in interdisciplinary and translational research that is directly applicable to problems in patient care. The successful candidate is expected to develop an internationally recognized and an externally funded research program. Excellent teaching and communication skills as well as a strong commitment to professional, graduate and post-doctoral education are essential.


For consideration, please apply online at Jobs@USC, Requisition ID# REQ20044132 @ https://jobs.usc.edu/applicants


Link: https://jobs.sciencecareers.org/job/457753/assistant-associate-or-professor/
Employer: University of Southern California
Location: Los Angeles, CA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: July 21st, 2017
University of Southern CaliforniaLos Angeles, CAPhDNDGJul 21, 2017
Translational Scientist

Translational Scientist

(Click title to open job details in a new window.)
Description:

We sincerely invite applications from outstanding translational scientists who aim to conduct cutting-edge and innovative research. Successful applicants will be offered generous start-up packages and internationally competitive benefits. Positions will remain open until filled.


Requirements


M.D., and/or Ph.D. or equivalent degrees with postdoctoral training or prior faculty experiences in or related to the fields of translational medicine

Demonstrated track record of excellence in areas including but not limited to cancer, immunological diseases, cardiovascular diseases, and neurological diseases;

Applicants from all gender and ethnic groups with citizenships in any nationalities are encouraged to apply. The applications will be evaluated strictly based on scientific merits and translational potentials.

Required documents


Interested individuals are urged to send the following documents to zhoujie128@mail.tsinghua.edu.cn and pumchkyc@126.com with “Translational Medicine Faculty Application” in the subject line:


Cover letter

Curriculum vitae

Statement of research and teaching interests

Names and contact information of three referees who are willing to provide recommendation letters upon requests


Link: https://jobs.sciencecareers.org/job/457011/translational-medicine-investigator-positions-by-tsinghua-university-and-pumch/?LinkSource=PremiumListing
Employer: Tsinghua University School of Medicine
Location: Beijing, China
Sector: Academia
Degree required: MD and/or PhD
Conditions: NDG
Job posted: July 14th, 2017
Tsinghua University School of MedicineBeijing, ChinaMD and/or PhDNDGJul 14, 2017
Assistant, Associate or Full Professor, Environmental Health

Assistant, Associate or Full Professor, Environmental Health

(Click title to open job details in a new window.)
Description:

The Department of Environmental and Occupational Health (EOH) within the Robert Stempel College of Public Health & Social Work (RSCPHSW) at Florida International University (FIU) invites applications for two tenured/tenure-track faculty member at the Assistant/Associate/Professor rank (rank and tenure commensurate with qualifications).


The ideal candidate will be a visionary scientist who studies how the environment influences human health at every level from micro to macro—from the ways that molecules of pollutants alter the genome to the impact of climate change on global patterns of disease. Applicants should have a Ph.D., M.D., or the equivalent in a biomedical related subject.


The successful candidate will have a record of scholarship and demonstrated success in extramurally funded research as well as experience in teaching and mentorship. Proven ability to conduct innovative and/or state-of-the art research is required. The EOH Department is particularly interested in the “exposome”, or research that studies the totality of a person’s environmental exposures across the life span and how it affects human health. The research areas may include internal and external exposures that are not limited to chemical pollutants found in air and water, but also exposures arising from a variety of sources such as the microbiome, infectious agents, nutritional sources, and stress. A second area of increased interest is related to studies on the role of exposure to environmental pollutants across the lifespan on neurological, neurodegenerative and mental disease.


Link: https://www.startwire.com/express_apply_jobs/MjEyNF9lYTZkNTk3NzdkODcwNTc0M2I4NDNhYjVmYTNhY2M5Y19sdXVhX2k=?source=adzuna_l2
Employer: Florida International University
Location: Miami, FL
Sector: Academia
Degree required: PhD or MD
Conditions: NDG
Job posted: July 13th, 2017
Florida International UniversityMiami, FLPhD or MDNDGJul 13, 2017
Assistant Professor, Developmental and Translational Neurobiology

Assistant Professor, Developmental and Translational Neurobiology

(Click title to open job details in a new window.)
Description:

The Virginia Tech Carilion Research Institute (VTCRI) has launched a new center within the institute – the Developmental and Translational Neurobiology Center (DTNC; https://wp.vtc.vt.edu/dtnc/), to expand the institute’s research programs in cellular and molecular neurobiology in healthy development, disease, and trauma. There are currently two open assistant professor faculty positions – one for a neurobiologist studying mechanisms underlying brain development or neurodevelopmental disorders and one for a neurobiologist or neuro-immunologist studying neurodegenerative disease or brain injury. Applicants should have an earned doctorate, have completed postdoctoral training and demonstrated a track record of successful research, publications and either active extramural funding (preferably from NIH) or show distinct promise to obtain such funding. The new faculty will join a collaborative and highly successful group of investigators at the VTCRI with related research interests in a variety of areas of neuroscience. Competitive salary, space and start-up packages will be provided.


Link: https://www.startwire.com/express_apply_jobs/MjEyNF83YzNhNDViZTNiYTU0YjZmNDhlMWMyMmVmMTA4ZTViYl9sdXVhX2k=?source=adzuna_l2
Employer: Virginia Tech
Location: Blacksburg, VA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: July 12th, 2017
Virginia TechBlacksburg, VAPhDNDGJul 12, 2017
Research Associate, Thomsen Lab

Research Associate, Thomsen Lab

(Click title to open job details in a new window.)
Description:

Dr. Gretchen Thomsen’s Laboratory at the Cedars-Sinai Regenerative Medicine Institute is looking for personnel to join our dynamic group. The incumbent should have an interest in the basic science of stem cells and animal research. The laboratory technician will, under the direction of the PI and lab manager, assist in the conduct of research in amyotrophic lateral sclerosis (ALS) and traumatic brain injury (TBI).


Working under direct supervision, the Research Associate I performs a variety of routine experimental protocols and procedures to support the objectives of one or more laboratory research projects in a specific area of research. Assists in general laboratory activities, including maintenance of reagents and stocking of supplies. Files and monitors documents. Keeps accurate and detailed records of experiments and results. Assists in the operation of specialized equipment and machinery. Observes safety standards and procedures. The Research Assistant I will be able to perform routine rodent colony maintenance/observation, perform animal behavior tasks, as well as perform cellular, micro- and molecular biology procedures including, but not limited to DNA/RNA, KR, protein extraction, cell culture, Immunohistochemistry, and staining. This position does not have supervisory responsibilities.


Link: https://www.cedars-sinaimedicalcenter.apply2jobs.com/ProfExt/index.cfm?fuseaction=mExternal.showJob&RID=26548&CurrentPage=39
Employer: Cedars Sinai Medical Center
Location: Los Angeles, CA
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: July 10th, 2017
Cedars Sinai Medical CenterLos Angeles, CABA or BSALSJul 10, 2017
Research Technician

Research Technician

(Click title to open job details in a new window.)
Description:

The laboratory is seeking a motivated individual to join our efforts in exploring disease mechanisms and developing therapeutic strategies for amyotrophic lateral sclerosis and dementia. Under the direction of the Principal Investigator, the research technician will perform laboratory experiments which include DNA and RNA purification, quantitative PCR, gel electrophoresis, Western blots, DNA cloning, immunostaining and preparation of libraries for high throughput sequencing. The incumbent will also be responsible for handling patient samples and genetic testing of neurodegenerative conditions as part of a research project in collaboration with the ALS multidisciplinary clinic. Additional skills include maintenance of cell cultures, ordering necessary reagents to conduct experiments, and participation in joint upkeep of the lab. Experience in mouse handling and surgical procedures is preferred. The candidate will participate to the research activity of the lab and is expected to be fully engaged in the scientific projects, as well as participate to the scientific lab meetings. The individual must pay attention to details, can work independently under minimal supervision, possess good verbal and written communication skills, and work well as part of a team.


Link: https://partners.taleo.net/careersection/ghc/jobdetail.ftl?job=356045
Employer: Massachusetts General Hospital
Location: Charlestown, MA
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: July 9th, 2017
Massachusetts General HospitalCharlestown, MABA or BSALSJul 09, 2017
Neurologist, Rehabilitation Service

Neurologist, Rehabilitation Service

(Click title to open job details in a new window.)
Description:

As a neurologist on the Neurology and Rehabilitation Service at the Oklahoma City Veterans Affairs Health Care System,who subspecializes in rehabilitation. The duties of this position include: supervise residents and students and attend on the neurology inpatient service 2-3 months annually; attend on the rehabilitation inpatient service2-3 months annually; direct the power-mobility clinic; direct the spinal cord injury, spinal cord diseases, multiple sclerosis, and amyotrophic lateral sclerosis clinic; direct the stroke-care program. The applicant must be able toprovidecare and rehabilitation tothe following populations ofveterans: acute neurology patients in all outpatient and outpatient settings including intensive care units and emergency room; spinal cord injury, spinal cord disease, ALS and MS in the Hub and Spoke system of care; disabled patients due to neurological or orthopedic impairments for rehabilitation care on outpatient and inpatient settings. The applicant must be able to provide acute stroke and post-stroke care and supervise neurology stroke fellows who rotate at the VA. The applicant must participate in ongoing CARF accreditations activities for a Comprehensive Integrated Inpatient Rehabilitation Program, and assist in meeting standards forspecial accreditation in Stroke Rehabilitation. The applicant must be able to supervise neurology stroke fellows, neurology residents, other trainees and students who rotate on the Neurology Inpatient and Outpatient Service, and therefore must meet criteria for faculty appointment in Neurology at the University of Oklahoma Health Science Center.


Link: http://neurojobs.sfn.org/jobs/10054911/physician-neurologist
Employer: University of Oklahoma
Location: Oklahoma City, OK
Sector: Academia
Degree required: MD
Conditions: ALS
Job posted: July 7th, 2017
University of OklahomaOklahoma City, OKMDALSJul 07, 2017
Physician-Scientist (Faculty)

Physician-Scientist (Faculty)

(Click title to open job details in a new window.)
Description:

We seek Physician-Scientists with a basic science or translational research focus in adult-onset neurodegenerative diseases including Alzheimer’s, Parkinson’s, ALS or dementia. This position will complement and synergize with ongoing basic, translational and clinical research programs in the CTM and across Temple’s Medical campus. The CTM has state-of-the-art facilities in a new open-concept research building completed in 2012. The Center currently has multi-disciplinary research interests in gene and stem cell therapy, cardiac and neuronal signaling, heart failure, Alzheimer’s disease and mitochondrial pathobiology with research cores supporting imaging, gene therapy/vectors, bioenergetics and surgery/physiology. Interested candidates should have an MD or MD/PhD degree, and a strong academic record. Academic appointment is available at all levels and competitive packages will be offered based on qualifications.


Please send letters of interest and CV’s to:


Walter J. Koch, PhD, Director

Center for Translational Medicine

c/o Michael Lester

Temple University School of Medicine

3500 N Broad Street, MERB 941

Philadelphia PA 19140


Email: Michael.lester@tuhs.temple.edu


Link: https://jobs.sciencecareers.org/job/456348/physician-scientist-faculty-position-translational-medical-research-in-neurodegeneration/
Employer: Temple University
Location: Philadelphia, PA
Sector: Academia
Degree required: MD or MD/PhD
Conditions: ALS
Job posted: July 7th, 2017
Temple UniversityPhiladelphia, PAMD or MD/PhDALSJul 07, 2017
Professor

Professor

(Click title to open job details in a new window.)
Description:

Building on world class expertise in genetics and immunology, the UK DRI at Cardiff University are looking for a dynamic, innovative dedicated individual who will contribute across the UK DRI as well as within the host centre. You will direct an internationally competitive research programme within the UK Dementia Research Institute (UK DRI) relevant to the area of neurodegeneration, with the ultimate aim of improving human health. Drawing on the knowledge and expertise of other colleagues both within and outside of the UK DRI through collaborative inputs and team working. The UK DRI is looking to transform the field of dementias research and welcomes scientists from all disciplines including frontotemporal dementia.


If you would like to join us on this journey we can offer you excellent benefits, a great working environment, and an opportunity to be part of something that really will make a difference to people’s lives.


For informal enquiries please contact Centre Director, Professor Julie Williams: williamsj@cardiff.ac.uk +44(0) 29 2068 8326


Programme funding: £3 million provided over five years

Salary: an appropriate point on the Professorial pay scale


Closing date: 26 January 2018


Link: http://www.cardiff.ac.uk/dementia-research-institute/join-us/uk-dri-professors
Employer: Cardiff University
Location: Cardiff, Wales
Sector: Academia
Degree required: PhD
Conditions: FTD
Job posted: July 6th, 2017
Applications close: September 3rd, 2017
Cardiff UniversityCardiff, WalesPhDFTDJul 06, 2017
Research Study Coordinator

Research Study Coordinator

(Click title to open job details in a new window.)
Description:

The Division of Neuromuscular Disorders is seeking a Research Support Coordinator to join a very active clinical research program with multiple ongoing research studies. The primary focus of the work will be on investigator-initiated research in the fields of amyotrophic lateral sclerosis (ALS) and myasthenia gravis (MG). The research support coordinator will work closely with clinical research coordinators, data manager, statistician, clinical staff and the Principal Investigator.


Link: https://um.hodesiq.com/job_detail.asp?JobID=5473953
Employer: University of Miami
Location: Miami, Florida
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: July 4th, 2017
University of MiamiMiami, FloridaBA or BSALSJul 04, 2017
Computational Neuroscientist

Computational Neuroscientist

(Click title to open job details in a new window.)
Description:

The Krembil Research Institute at the University Health Network in Toronto Canada invites applicants to apply for a Scientist position in the area of Computational Neuroscience. The ideal candidate will have a PhD in a relevant field, research expertise and experience in mathematical and computational modeling, and research interests that complement those of the Institute in neurobiology and neurodegeneration. Candidates whose research interests encompasses cellular, micro/macro circuits and/or large scale brain models, and who have collaborative experimental experience are especially encouraged. The successful candidate will have the ability to establish an independent, well-funded program and will be eligible for appointment at the appropriate level within the University of Toronto.


Link: https://www.recruitingsite.com/csbsites/uhncareers/JobDescription.asp?SiteID=10031&JobNumber=805761
Employer: Krembil Research Institute
Location: Toronto, Canada
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: July 1st, 2017
Applications close: August 28th, 2017
Krembil Research InstituteToronto, CanadaPhDNDGJul 01, 2017
Research Associate, ViTAL Consortium

Research Associate, ViTAL Consortium

(Click title to open job details in a new window.)
Description:

The postholder will join the ViTAL consortium of researchers working on Amyotrophic Lateral Sclerosis (ALS), funded by the charity TARGET-ALS. They will identify toxic elements that are secreted through exosomes in ALS, and determine their role in ALS. (Fixed-term until 30 June 2018)


We prefer to issue and receive applications via our on-line recruitment website at www.ulster.ac.uk/jobs


Hard copy applications can be obtained by telephoning 028 7012 4072


Link: http://www.nature.com/naturejobs/science/jobs/618061-research-associate-in-als-disease
Employer: University of Ulster
Location: Belfast, Ireland
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: June 26th, 2017
University of UlsterBelfast, IrelandBA or BSALSJun 26, 2017
Research Scientist

Research Scientist

(Click title to open job details in a new window.)
Description:

The Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco (UCSF) is seeking a molecular/cell biologist to design, develop and validate novel tools for the study of neurodegenerative diseases. The director of the IND is Nobel Laureate Dr. Stanley Prusiner.


The successful candidate will have a strong track record in neuroscience research and will join a multi-disciplinary team of scientists dedicated to finding a cure for neurodegenerative diseases by discovering small molecule drugs that prevent the propagation of misfolded proteins in cells, animal models, and eventually, human patients. The team is engaged in fundamental research to understand the process of protein misfolding as well as translational research to apply this knowledge toward drug discovery assays. The candidate should have strong practical experience in protein expression and cell culture. He or she should have excellent management and communication skills and work well in a team environment.


QUALIFICATIONS


Ph.D. with emphasis in neuroscience or neuropharmacology

At least 3 years of post-Ph.D. experience in both molecular and cell biology, including:

DNA cloning and the construction of expression vectors

Transfection and viral infection

Western blotting, immunoprecipitation and protein purification

Cell line differentiation

Stable transfection and cloning

Candidates with experience in cell-based assay development and/or cellular models of neurodegenerative diseases are strongly encouraged to apply

Applicants should possess excellent managerial, leadership, organizational, communication, and interpersonal skills, as well as exhibit evidence of imagination in problem solving.

Preference will be given to candidates with a demonstrated superb command of oral and written English.

This is a full-time position with excellent benefits. Salary is dependent upon experience. Rank will be commensurate with background, experience, and work history.


Interested applicants should submit curriculum vitae with a list of publications, a brief statement of research accomplishments and interests, and contact information for three professional references.


Please apply online at https://aprecruit.ucsf.edu/apply/JPF01324


Link: https://aprecruit.ucsf.edu/apply/JPF01324
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: June 23rd, 2017
University of CaliforniaSan Francisco, CAPhDNDGJun 23, 2017
Postdoctoral Fellow, Neurotherapeutics

Postdoctoral Fellow, Neurotherapeutics

(Click title to open job details in a new window.)
Description:

The research at the Division of Protein Technology is to a large extent focused on development of affinity proteins, including design and engineering of new functions and properties. Affinity protein development is a growing research discipline worldwide with applications in several fields such as biotech and medicine. The group of Biotherapy and Bacterial display has wide experience in combinatorial protein engineering of affinity proteins and has developed methods for such purposes exploiting both phage and bacteria.


The group is currently coordinating projects for development of new protein-based drug candidates targeting proteins and peptides involved in various neurological disorders, such as Frontotemporal Degeneration, Alzheimer’s and Parkinson’s diseases. For these projects, a post-doc position is open. The vacancy center on combinatorial protein engineering technologies, i.e. expression of large collections of protein variants on microorganisms and selection of candidates with desired properties from such collections. It will include exploiting and developing such technologies for generation and investigation of new protein-based reagents to generate affinity-based drug candidates. In line with KTH’s equal opportunity policy, we strongly encourage qualified female and minority candidates to apply.


Qualifications

The candidate should hold a PhD and an analytical/technical interest in molecular biotechnology and/or protein chemistry. Documented experience in protein engineering methodology, such as phage/yeast/bacterial display for generation of proteins with improved properties, is required. Theoretical knowledge of combinatorial protein engineering, including protein library design, is considered a distinct advantage. Experience with FACS, cell assays, recombinant protein production and purification (including affinity chromatography and HPLC) as well as biosensor assays (e.g. SPR-based), is also important.


Employment

Form of employment: Full-time and time-limited. One year, renewable one year.

Start date: As soon as possible

Salary: Salary follows the guidelines provided by KTH


Application

More information about how to apply can be found at https://www.kth.se/en/om/work-at-kth/lediga-jobb/what:job/jobID:158504/where:4/


Link: https://www.kth.se/en/om/work-at-kth/lediga-jobb/what:job/jobID:158504/where:4/
Employer: KTH Royal Institute of Technology
Location: Stockholm, Sweden
Sector: Academia
Degree required: PhD
Conditions: FTD
Job posted: June 22nd, 2017
Applications close: August 22nd, 2017
KTH Royal Institute of TechnologyStockholm, SwedenPhDFTDJun 22, 2017
Postdoctoral Fellow, Sareen Lab

Postdoctoral Fellow, Sareen Lab

(Click title to open job details in a new window.)
Description:

Dr, Dhruv Sareen’s independent research laboratory at the Cedars-Sinai Medical Center, Regenerative Medicine Institute focuses on using human iPSC technology to understand the molecular mechanisms underlying neurodevelopmental/degenerative diseases and how obesity is linked to the brain. His laboratory is particularly interested ‘disease-in-a-dish’ modeling for neuromuscular, neurodegenrative and motor neuron diseases including, amyotrophic lateral sclerosis (ALS). They are particularly interested in C9orF72 and other genetic forms of ALS and what are the common elements with sporadic forms of ALS. Using the iPSC platform his lab has developed novel methods for drug screening on patient motoneurons and dissecting mechanisms for motoneuron degeneration. In the context of stem cell modeling of neurodevelopmental (SMA) and neurodegenerative diseases (ALS) Dr. Sareen’s group is particularly interested in the mechanistic insights how specific neural cell types degenerate during the disease processes. They are using OMICS (proteome, transciptome, metabolome) and imaging methodologies to gain mechanistic insights into the mitochondrial and endorplasmic reticulum stress involvement. In addition, by understanding how the cells of the nervous system develop and differentiate we will be able to develop better and safer cells for transplantation and regenerative therapies. Dr. Sareen’s group has extensive experience in pluripotent and neural stem cell research. He has developed and directed a well-renowned human iPS cell core. He has published high-profile manuscripts on human iPSC-based disease modeling in SMA and ALS.


Dr. Sareen’s laboratory is searching for a highly-capable Post-doctoral Researcher to join his research group to investigate disease mechanisms in neurodegenerative diseases, especially motor neuron disorders. The incumbent should have experience in in neurobiology, biochemistry, molecular biology and stem cells, including analyzing their genetic and biochemical profiles by OMICS technologies. Bioinformatics (programming in R) knowledge is a plus. By using human iPS cell technology and differentiating into different brain cells as well as other tissues of the body we will investigate brain-linked disease mechanisms to develop assays in patient-derived enural cell types and screen for novel therapeutics. Working independently but in close cooperation and in consultation with the PI and other Research Scientists at RMI, the Post-doctoral Researcher will perform routine and complex laboratory procedures throughout. The Post-doctoral Researcher will be expected to assist the PI in preparation of multiple grant proposals and submission of such proposals. They will also prepare full manuscripts for publication as primary first and co-authors. The researcher will be expected to assist the PI in maintaining institutional IRB/SCRO protocols as well as develop new animal and IACUC protocols. The incumbent will develop, adapt, and implement new research techniques and protocols and will analyze and interpret data. They will participate in presentations as author or co-author on scientific meeting abstracts.

Under the direction of Dr. Sareen (PI) the incumbent will help us achieve our research goals by performing the principal duty of using pluripotent and neural stem cell culture techniques to generate neuronal and other tissue differentiation protocols, characterization of the differentiated cells (control vs disease) using techniques such as gene and protein expression, physiological, and phenotypic assessments. The candidate will also be expected to develop and perform differentiation protocols to direct pluripotent stem cells to endoderm, ectoderm and mesoderm lineages. The successful candidate will be responsible for all cell maintenance, expansion and genetic modification using viral vectors or other gene-editing methods. Therefore, experience in stem cell and neurobiology, knowledge of pluripotent/neural cell markers combined with a proven record in stem cell culture techniques is essential. Experience with bioinformatics analysis of RNA-seq and mass spec proteomics data are important. Prior experience in novel genome-editing technologies (CRISPR/Cas9) using pluripotent stem cells is a great asset. Prior experience in high-content compound screening/imaging techniques, handling of the Molecular Devices Image Express Micro system, and a Mass Spectrometer with data analysis are preferred traits. Proficiency in computer algorithm development for automating image-based analysis is also a desirable trait.


Link: https://www.cedars-sinaimedicalcenter.apply2jobs.com/ProfExt/index.cfm?fuseaction=mExternal.showJob&RID=26507&CurrentPage=33
Employer: Cedar Sinai Medical Center
Location: Los Angeles, CA
Sector: Academia
Degree required: MD, PhD, VMD, or DDS
Conditions: ALS
Job posted: June 22nd, 2017
Cedar Sinai Medical CenterLos Angeles, CAMD, PhD, VMD, or DDSALSJun 22, 2017
Research Associate

Research Associate

(Click title to open job details in a new window.)
Description:

Under the supervision of the Principal Investigator, the Staff Research Associate II (SRA II) will assist in the performance of behavioral testing and in the analysis of behavioral and neuroimaging data to support research on the neural bases of decision-making in healthy individuals with a family history of frontotemporal dementia. Specific techniques utilized in these studies will include online computer-based testing, task-based functional MRI, psychophysiology, voxel-based morphometry, functional connectivity, and computational modeling of behavior.


Responsibilities will include assistance in delivering online task-based behavioral assessments, in conducting behavioral/fMRI/psychophysiological testing with research subjects, performing image preprocessing and supervised analyses, managing and reporting on study results, overseeing study data integrity, and reporting study progress to the research team. The position represents an excellent opportunity to further develop research skills and learn basic principles of clinical and cognitive neuroscience.


Link: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?partnerid=6495&siteid=5226&jobId=2511562
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: BA or BS
Conditions: FTD
Job posted: June 22nd, 2017
University of CaliforniaSan Francisco, CABA or BSFTDJun 22, 2017
Graduate Studentship, Vande Velde Lab

Graduate Studentship, Vande Velde Lab

(Click title to open job details in a new window.)
Description:

Dr. Christine Vande Velde is looking to recruit a graduate student to her laboratory located at the CRCHUM facility, a research center affiliated with the Université de Montréal and located in Downtown Montreal.


Our lab is focused on understanding the molecular pathways that contribute to motor neuron degeneration in amyotrophic lateral sclerosis (ALS; also known as Lou Gehrig’s disease and Maladie de Charcot). Techniques include molecular biology, biochemistry, cell biology, and microscopy. We use both tissue culture and transgenic rodent models of disease. Projects include characterizing the role of TDP-43 in RNA granule dynamics, defining pathogenic mechanisms induced by misfolded SOD1, and exploration on hnRNP A1 in ALS biology. We are a young dynamic and bilingual team and we would like to add highly motivated individuals to the current crew. Salary will be based on institutional/CIHR guidelines.


Please submit your CV, your transcripts, and the names and contact information of three referees to c.vande.velde@umontreal.ca. Potential candidates will be contacted for an interview.


Selected Papers


K.K. McDonald, A. Aulas, L. Destroismaisons, S. Pickles, E. Beleac, W. Camu, G.A. Rouleau, and C. Vande Velde. (2011). TAR DNA-Binding Protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1. Human Molecular Genetics 20:1400-1410.


C. Vande Velde*, K.K. McDonald, Y. Boukhedimi, M. McAlonis-Downes, C.S. Lobsiger, S. Bel Hadj, A.N. Zandona, J.P. Julien, S.B. Shah and D.W. Cleveland*. (2011). Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset. PLoS One 6:e22031. *co-corresponding author.


S. Pickles and C. Vande Velde. (2012) Misfolded SOD1 and ALS: Zeroing in on mitochondria. Amyotrophic Lateral Sclerosis 13: 333-340. (invited review).


A. Aulas, S. Stabile and C. Vande Velde. (2012). Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP. Molecular Neurodegeneration 7:54.


S. Pickles, L. Destroismaisons, S.L. Peyrard, S. Cadot, R.H. Brown Jr, G.A. Rouleau, J.P. Julien, N. Arbour and C. Vande Velde. (2013). Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1. Human Molecular Genetics 22: 3947- 3959.


A. Aulas, G. Caron, C.G. Gkogkas, N.-V. Mohamed, L. Destroismaisons, N. Sonenberg, N. Leclerc, J.A. Parker, and C. Vande Velde. (2015). G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA. Journal of Cell Biology 209: 73-84.


Employer: CRCHUM
Principal investigator: Université de Montréal
Location: Montréal, Canada
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: June 20th, 2017
CRCHUMMontréal, CanadaBA or BSALSJun 20, 2017
Postdoctoral Fellow, Vande Velde Lab

Postdoctoral Fellow, Vande Velde Lab

(Click title to open job details in a new window.)
Description:

Dr. Christine Vande Velde is looking to recruit a PostDoc to her laboratory located at the CRCHUM facility, a research center affiliated with the Université de Montréal and located in Downtown Montreal.


Our lab is focused on understanding the molecular pathways that contribute to motor neuron degeneration in amyotrophic lateral sclerosis (ALS; also known as Lou Gehrig’s disease and Maladie de Charcot). Techniques include molecular biology, biochemistry, cell biology, and microscopy. We use both tissue culture and transgenic rodent models of disease. Projects include characterizing the role of TDP-43 in RNA granule dynamics, defining pathogenic mechanisms induced by misfolded SOD1, and exploration on hnRNP A1 in ALS biology. We are a young dynamic and bilingual team and we would like to add highly motivated individuals to the current crew. Salary will be based on institutional/CIHR guidelines.


Please submit your CV, your transcripts, and the names and contact information of three referees to c.vande.velde@umontreal.ca. Potential candidates will be contacted for an interview.


Selected Papers


K.K. McDonald, A. Aulas, L. Destroismaisons, S. Pickles, E. Beleac, W. Camu, G.A. Rouleau, and C. Vande Velde. (2011). TAR DNA-Binding Protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1. Human Molecular Genetics 20:1400-1410.


C. Vande Velde*, K.K. McDonald, Y. Boukhedimi, M. McAlonis-Downes, C.S. Lobsiger, S. Bel Hadj, A.N. Zandona, J.P. Julien, S.B. Shah and D.W. Cleveland*. (2011). Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset. PLoS One 6:e22031. *co-corresponding author.


S. Pickles and C. Vande Velde. (2012) Misfolded SOD1 and ALS: Zeroing in on mitochondria. Amyotrophic Lateral Sclerosis 13: 333-340. (invited review).


A. Aulas, S. Stabile and C. Vande Velde. (2012). Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP. Molecular Neurodegeneration 7:54.


S. Pickles, L. Destroismaisons, S.L. Peyrard, S. Cadot, R.H. Brown Jr, G.A. Rouleau, J.P. Julien, N. Arbour and C. Vande Velde. (2013). Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1. Human Molecular Genetics 22: 3947- 3959.


A. Aulas, G. Caron, C.G. Gkogkas, N.-V. Mohamed, L. Destroismaisons, N. Sonenberg, N. Leclerc, J.A. Parker, and C. Vande Velde. (2015). G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA. Journal of Cell Biology 209: 73-84.


Employer: CRCHUM
Principal investigator: Université de Montréal
Location: Montréal, Canada
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: June 20th, 2017
CRCHUMMontréal, CanadaPhDALSJun 20, 2017
Director, Institute of Biotechnology

Director, Institute of Biotechnology

(Click title to open job details in a new window.)
Description:

Helsinki Institute of Life Science HiLIFE of the University of Helsinki is seeking a Director of the Institute of Biotechnology (bi.helsinki.fi). The Institute of Biotechnology (BI) is at the forefront of molecular biology research with eight current ERC grantees, and has a strong focus in biotechnology through developing new strategies e.g. to combat neurodegenerative and metabolic diseases. Current research programs at the BI are in Cell and Molecular Biology, Developmental Biology, Genome Biology, and Structural Biology and Biophysics. BI is an international, competitive and rewarding workplace, where the staff within the 25 research groups and 7 core facilities exceeds 250 and comes from 30 different countries. As of 2017 the Institute of Biotechnology is a unit of HiLIFE (www.helsinki.fi/hilife) and collaborates locally across life science units and organizations.


Expectations and conditions

Qualified candidates will be visionary scientific leaders of international stature and with a strong track record of innovative research in relevant areas, and with merits in building interdisciplinary academic research in a highly collaborative environment.


The Institute of Biotechnology Director will

• Be responsible for development of the institute, including producing and implementing a vision for future scientific growth as well as the recruitment of a new generation of outstanding and highly interactive researchers

• Lead her/his own research group

• Foster new collaborations including ones at the University of Helsinki and HiLIFE


The anticipated start date is January 2018 or earlier. The position is initially for five years with a possibility of renewal, and associated with funding for the group and a startup package when appropriate. The salary is negotiable within the salary system of Finnish universities.


Qualifications and experience

The successful candidate will

• Hold an appropriate doctoral degree

• Have an outstanding record of scientific discoveries and success in obtaining funding

• Present a clear vision of future directions in relevant research areas

• Demonstrate successful leadership of international and diverse teams

• Show a commitment to fostering excellence in scientific research and research training


Application deadline, inquiries and nominations

Applications are welcome until August 14, 2017. For further information or proposals for nominations please contact HiLIFE Director Tomi Mäkelä by email hilife-recruit@helsinki.fi or by phone +358 2941 25500.


Submission of applications

Applications are submitted to hilife-recruit@helsinki.fi as a single pdf file with

i) your vision for the development of the Institute of Biotechnology;

ii) your research plan (max 5 pages);

iii) your CV (max 4 pages including biosketch);

iv) a list of not more than 10 selected publications with motivation for selecting each;

v) a link or reference (e.g. ORCID) to a complete list of publications.


Link: http://www.nature.com/naturejobs/science/jobs/617619-director-of-the-institute-of-biotechnology
Employer: University of Helsinki
Location: Helsinki, Finland
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: June 17th, 2017
University of HelsinkiHelsinki, FinlandPhDNDGJun 17, 2017
Computational Chemist

Computational Chemist

(Click title to open job details in a new window.)
Description:

The Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco (UCSF) is seeking a computational/theoretical chemist to join the IND’s drug discovery programs in Alzheimer’s disease, frontotemporal dementia, Parkinson’s disease, Creutzfeldt-Jakob disease and others. The director of the IND is Nobel Laureate Dr. Stanley Prusiner.


The successful candidate will work with the drug discovery team as a computational chemist to identify and validate cellular high-throughput screening hits. For molecules in the lead optimization phase, the candidate should be able to influence and accelerate creative molecular design using modern computational tools and approaches.


He or she will possess an expert-level understanding of medicinal chemistry principles, including the optimization of properties favorable for a CNS therapeutic. He or she is expected to work closely with medicinal chemists at the IND and with our drug discovery partners at Daiichi Sankyo. The candidate should have excellent communication skills and work well in a team environment.


QUALIFICATIONS


• PhD in Chemistry with experience in the design of small molecule drug candidates.

• A strong track record of creative problem solving and scientific achievement

• A high level of expertise with quantum mechanical and other computational techniques to understand the conformational and stereoelectronic properties of small molecules

• A strong interest in conformational analysis and the ability to provide examples of how insights into conformation can lead to improved biological activity

• Proficiency with force field-based molecular dynamics methods to study the role of structure and conformational mobility of proteins for the purpose of drug design

• An understanding of the physical chemistry of ligand design and binding thermodynamics with experience docking small molecules with associated proteins

• Applicants should possess excellent leadership, organizational, communication and interpersonal skills

• Preference will be given to candidates with a demonstrated superb command of oral and written English


This is a full-time position with excellent benefits. Salary is dependent upon experience.


Interested applicants should submit curriculum vitae with a list of publications, cover letter, a research summary (4-page max. including figures), and contact information for three professional references.

Please apply online at https://aprecruit.ucsf.edu/apply/JPF01488


Link: https://aprecruit.ucsf.edu/apply/JPF01488
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: PhD
Conditions: FTD
Job posted: June 15th, 2017
Applications close: July 15th, 2017
University of CaliforniaSan Francisco, CAPhDFTDJun 15, 2017
Research Assistant, Neurodegenerative Disease

Research Assistant, Neurodegenerative Disease

(Click title to open job details in a new window.)
Description:

As a research assistant, the successful candidate will work with protein analysis (Western blot), histological analysis (immunofluorescence, in situ hybridization), analysis of data from in vivo neurotransmitter recordings (glutamate, dopamine recordings) and cytological analysis (immunofluorescence). The source of these samples will be from cell lines, animal models and human samples. The applicant will work close with patients and perform skin biopsies, blood sampling and lumbar punctures to obtain working material. The applicant will be responsible for analyzing these samples according to their respective protocols and the analyses are documented and stored in structured and easy to follow way.


The applicant will be expected to work well independently and as part of a team, establishing and maintaining collaborations. They should be motivated to work in an international and multidisciplinary research group. The applicant must also be able to perform interventions on patients as for the position is required to take patients samples as indicated above. Moreover, part of the job will be the access to the patients data sheets and categorize the samples regarding to the medical history of the patients.


Entry Requirements


The applicant must have an academic degree in the field of Medicine as she/he will need to have access to patient data and make medical interventions. A strong background in molecular and cellular imaging, preferably in the neuroscience field, is advantageous. Applicants may have spent part of their education in a foreign country, bringing international experience and a strong team spirit to the laboratory. Excellent command of the English language is highly preferred. It is also important that the applicant has clinical experience, for example taking skin biopsies, blood and biological fluid samples.


Link: https://ki.mynetworkglobal.com/se/what:job/jobID:152108/type:job/where:4/apply:1
Employer: Karolinska Institutet
Location: Stockholm, Sweden
Sector: Academia
Degree required: A university medical degree
Conditions: NDG
Job posted: June 14th, 2017
Karolinska InstitutetStockholm, SwedenA university medical degreeNDGJun 14, 2017
Lab Manager, Neurosciences Clinical Research Unit

Lab Manager, Neurosciences Clinical Research Unit

(Click title to open job details in a new window.)
Description:

The position is responsible for, and critically important to Neurosciences Clinical Research Unit (NCRU), and Memory and Aging Center (MAC) investigators for the overall operational management of clinical research activities for the biospecimens processing lab. The Lab Manager has direct responsibility for implementing a diverse portfolio of processing protocols which include multicenter clinical trials (both NIH and industry-sponsored), local investigator-initiated clinical trials, and clinical research activities, including a clinical database and biorepository LIMS system.


Required Qualifications

• BA/BS degree with a major in a related science and two or more years of recent, directly related work experience following degree completion, utilizing the techniques or methods required by the position and demonstrating technical expertise in these areas; or an equivalent combination of education and experience

• Knowledge of basic lab equipment

• Experience with sample processing

• Ability to handle data and samples meticulously, in a well-organized manner, with understanding of Good Documentation Practices

• Demonstrated ability to work under time pressure with attention to detail


Link: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?partnerid=6495&siteid=5226&jobId=2503229
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: BA or BS
Conditions: FTD
Job posted: June 9th, 2017
University of CaliforniaSan Francisco, CABA or BSFTDJun 09, 2017
Neuropathologist

Neuropathologist

(Click title to open job details in a new window.)
Description:

The Department of Pathology and Laboratory Medicine at the University of California (UC) Davis, School of Medicine is seeking a dynamic academic physician-investigator to provide clinical service and teaching in neuropathology, and who can develop an independent hypothesis-based research program in an area of neuroscience, such as Alzheimer’s disease or other neurodegenerative conditions, autism/neurodevelopmental disorders, neoplastic neuropathology. The expectation is that the candidate will spend approximately 30-50% clinical service and teaching and 50-70% research. Clinical duties will focus on surgical and autopsy neuropathology, though other subspecialty areas of anatomic pathology could be also considered based on the candidate’s training and interests. Teaching duties may include clinical, didactic, laboratory and small group teaching of housestaff, medical students, graduate students, and students in other health professional programs, and participation in interdisciplinary clinical conferences.


The successful candidate will have the opportunity to build on the many neuroscience strengths in the department, UC Davis Health System and UC Davis campus, including an established program in neuropathology, strong collaborative relationships with the Alzheimer Disease Center, MIND Institute, the Institute for Regenerative Medicines, Comprehensive Cancer Center, and the campus’ Center for Neuroscience, Center for Comparative Medicine, School of Veterinary Medicine, the California National Primate Center, and more.


Requirements include MD or MD/PhD, board-eligible or certified in anatomic pathology and neuropathology, and have an appropriate record of accomplishment in clinical service, teaching and research to meet requirements for appointment at the Assistant, Associate Professor level ( 50% Tenure Track / 50% In Residence). Eligibility for licensure to practice medicine in California is required. Other required skills include the ability to work cooperatively and collegially within a diverse environment, and the ability to build and maintain productive professional relationships with medical and technical staff, trainees, and others.


For full consideration, applications must be received by January 31, 2018; however, we will have our first review of applicants September 30, 2017. Position will be open until filled, but no later than June 30, 2018. Please forward the following: (1) Curriculum Vitae; (2) Cover letter; (3) Statement of clinical, teaching and research background; (3) List of names and contact information for at least five references to: http://apptrkr.com/1016588


Link: http://jobs.sciencecareers.org/job/452156/academic-neuropathologist/
Employer: University of California
Location: Davis, California
Sector: Academia
Degree required: MD or MD/PhD
Conditions: NDG
Job posted: June 8th, 2017
Applications close: January 31st, 2018
University of CaliforniaDavis, CaliforniaMD or MD/PhDNDGJun 08, 2017
Research Scientist, Neuroinflammation

Research Scientist, Neuroinflammation

(Click title to open job details in a new window.)
Description:

The Krembil Research Institute at the University Health Network in Toronto Canada is seeking an early to mid career basic scientist in the area of neuroinflammation. Preference will be given to individuals with a research focus on the involvement of innate immunity, including the roles of immune mediators such as microglia and astrocytes, and their expressed cytokines and chemokines, in neurodegenerative diseases affecting the human CNS. The successful candidate will have a PhD or MD/PhD, postdoctoral experience and demonstrated research excellence. The successful candidate will be expected to qualify for an appointment at the Assistant or Associate Professor level (status only) in the appropriate department at the University of Toronto.


The Krembil is one the principal research institutes of the University Health Network of academic teaching hospitals associated with the University of Toronto; the Krembil is also one of the largest research institutes in Canada focusing on human neurological disease from both a basic science and clinical research perspective. The University Health Network (UHN) is Canada’s largest academic medical centre, comprising four major teaching hospitals.



Qualifications


• Ph.D. in specialized discipline or advanced degree and 5 years closely related experience

OR

• Combination of education, experience and demonstrated ability that is recognized as equivalent

• Demonstrative ability to engage and work collaborative with all levels and members of the inter-professional team, research team and external stakeholders

• Demonstrated effective communication (written and verbal), problem-solving and

consensus-building skills


Qualified applicants are invited to submit their application (letter of interest, research plan, curriculum vitae) in PDF format. You will also be required to complete some initial screening questions. The search committee will begin to review applications in September with a potential start date in Winter 2018.


Link: http://jobs.sciencecareers.org/job/452043/scientist-in-neuroinflammation/
Employer: Krembil Research Institute
Location: Toronto, Canada
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: June 8th, 2017
Krembil Research InstituteToronto, CanadaPhDNDGJun 08, 2017
Assistant Professor, Psychiatry

Assistant Professor, Psychiatry

(Click title to open job details in a new window.)
Description:

The University of California, Irvine is recruiting an Assistant Professor for its growing Department of Psychiatry and new Sleep center. The successful candidate will be an outstanding researcher in sleep neuroscience, in particular, quantitative EEG and neuroimaging approaches to understanding neurodegenerative diseases such as Alzheimer’s disease, and the relationship between sleep and cognitive function. This is a Professor Series (academic senate) tenure-line appointment. Salary will be commensurate with training and experience. UC Irvine, located in Orange County, with a population of more than three million, has a long and distinguished tradition of excellence in neuroscience.


Requirements – Research-related experience in sleep, EEG analysis, neurodegenerative diseases and/or functional imaging desirable. Successful candidates must have a Ph.D. and/or a M.D. degree and a record of high-quality research, with scholarly activity and publications commensurate with experience. Candidates with extramural funding or submitted applications for mentored or independent awards, particularly from the federal government, are especially sought. It is expected that the successful candidate will develop an extramurally funded research program.


For further information and correspondence, please contact:

Ruth M. Benca, M.D. – Ph.D.

Professor and Chair

Department of Psychiatry and Human Behavior

Bldg. 3, Room 367

Orange, CA 92868


TO APPLY: Please log onto UCI RECRUIT located at: https://recruit.ap.uci.edu/apply/JPF03986


Applicants should complete an online application profile and upload the following application materials electronically to be considered for the position:


Cover letter

Curriculum vitae

Statement of Research—Please include a description of current research and future plans.

Three references with contact information

Diversity Statement


Link: https://recruit.ap.uci.edu/apply/JPF03986
Employer: University of California
Location: Irvine, CA
Sector: Academia
Degree required: PhD and/or MD
Conditions: NDG
Job posted: June 6th, 2017
Applications close: July 31st, 2017
University of CaliforniaIrvine, CAPhD and/or MDNDGJun 06, 2017
Senior Research Investigator

Senior Research Investigator

(Click title to open job details in a new window.)
Description:

This is an exciting and challenging position which will play a lead role in establishing a new research group at MRC Harwell, as part of a new collaborative programme between MRC Harwell and UCL Institute of Neurology to study neurodegeneration. This will involve making straight-forward gene targeted models for studying neurodegeneration, and also entirely novel genomic knock ins. You should have some hands on experience of genomic cloning and/or homologous recombination and will be able to learn novel technologies including CRISPR/Cas9 to produce new models for studying specific questions in neurodegenerative disease research. This is a pivotal post, as you will liaise with a group of neuroscientists to create the best models for tackling specific questions in neurodegeneration. You will supervise a team that includes a junior postdoc and two skilled laboratory technicians, providing them with support for their career progression.

For further information please visit our website – https://www.har.mrc.ac.uk/about/mammalian-genetics-unit


About You

You will be skilled in the areas of gene targeting/genome engineering/gene editing in the mouse, with peer-reviewed publications. You must have a PhD in an appropriate discipline (e.g. Genetics, Cell Biology) and a proven track-record in carrying out scientific research to an international standard. You must also demonstrate the ability to work in a multi-disciplinary collaboration, being able to communicate with colleagues working in a different location.


For full details of this post and to complete an online application, visit https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/609 and upload your CV along with a covering letter stating why you are applying for this role. Please quote reference number MGU 562.


Closing date: 3rd July 2017


Link: https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/609
Employer: MRC Harwell
Location: Harwell, England
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: June 6th, 2017
Applications close: July 3rd, 2017
MRC HarwellHarwell, EnglandPhDNDGJun 06, 2017
Postdoctoral Fellow, Gao Lab

Postdoctoral Fellow, Gao Lab

(Click title to open job details in a new window.)
Description:

A postdoctoral position is immediately available in the laboratory of Dr. Fen-Biao Gao at the University of Massachusetts Medical School to study molecular pathogenic mechanisms of fronototemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).


PhD required. Candidates with strong research experience in stem cell biology or molecular and cellular biology are encouraged to apply. Two years’ experience with cell culture (primary and cell lines), stem cell/neuronal differentiation preferred.


To Apply: Please forward CV to: Fen-Biao.Gao@umassmed.edu.


Link: http://www.nature.com/naturejobs/science/jobs/605061-postdoctoral-position
Employer: University of Massachusetts Medical School
Location: Worcester, MA
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: June 5th, 2017
Applications close: August 4th, 2017
University of Massachusetts Medical SchoolWorcester, MAPhDALS, FTDJun 05, 2017
Postdoctoral Fellow, Van Den Bosch Lab

Postdoctoral Fellow, Van Den Bosch Lab

(Click title to open job details in a new window.)
Description:

The research project, under supervision of principal investigator Ludo Van Den Bosch, will focus on the role of low complexity domains in disease-causing proteins, with a special focus on the dipeptide repeat proteins (DPRs) encoded from the hexanucleotide repeats in C9orf72. Effects of these DPRs on the nucleocytoplasmic transport and stress granule formation will be investigated. Biophysical techniques will be used to study the structural characteristics and dynamics of these structures. Moreover, this research will involve in vitro techniques including work with iPSCs, as well as in vivo research using small animal models (Drosophila and zebrafish).


Profile


​We are looking for a highly motivated postdoctoral researcher with interest in neurodegeneration and experience in. Motivated candidates with a strong commitment to basic research are invited to apply.


The candidate:


should hold a PhD degree in biology, biochemistry or biomedical sciences

should have experience in research on neurodegenerative disorders

should be able to work in a team with a high degree of autonomy

should be able to guide and supervise PhD students

should fluently speak and write English.


We offer a fulltime 3 year contract for a postdoctoral position in an enthusiastic and motivated team and a dynamic scientific work environment. The Center for Brain & Disease (CBD) at KU Leuven is an international research group focusing on neuroscience. The CBD provides different opportunities to present and share data on weekly seminars, lectures and international conferences. Different state-of-the-art core facilities are available for all CBD researchers.


For additional information concerning this job offer, please contact Lien Houbrechts (lien.houbrechts@kuleuven.vib.be)


How to apply?


http://www.vib.be/en/jobs/Pages/Postdoctoral-Researcher-Investigating-the-Role-of-Phase-Transitions-and-Stress-Granule-Dynamics-in-Neurodegeneration.aspx


Link: http://www.vib.be/en/jobs/Pages/Postdoctoral-Researcher-Investigating-the-Role-of-Phase-Transitions-and-Stress-Granule-Dynamics-in-Neurodegeneration.aspx
Employer: VIB
Location: Leuven, Belgium
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: June 1st, 2017
Applications close: July 31st, 2017
VIBLeuven, BelgiumPhDALS, FTDJun 01, 2017
Research Specialist, Plotkin Lab

Research Specialist, Plotkin Lab

(Click title to open job details in a new window.)
Description:

A full-time position is available in the lab of Alice Chen-Plotkin in the Department of Neurology at the University of Pennsylvania. Our lab researches neurodegenerative disease, with a particular focus on frontotemporal dementia and Parkinson’s disease. Projects range from studying the basic mechanisms of disease to finding and developing clinically useful tools such as biomarkers. Responsibilities for this position will include assistance with biochemical, molecular biological, and cell biological assays as needed to meet scientific goals. In addition, familiarity with analysis of large genetic datasets is preferred, including knowledge of statistical and computational methods (i.e. familiarity with linear/logistic regression, ability to use R or other statistical tools). All members of the lab are also expected to attend weekly lab meetings and to participate in the educational activities (e.g. journal club) of the lab.


Internal Number: 28742


Link: http://www.cellbiologyjobs.org/jobs/9115682/research-specialist-a
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: BS
Conditions: FTD
Job posted: June 1st, 2017
University of PennsylvaniaPhiladelphia, PABSFTDJun 01, 2017
Postdoctoral Fellow, Mueller Lab

Postdoctoral Fellow, Mueller Lab

(Click title to open job details in a new window.)
Description:

Responsible for advancing the lab’s preclinical programs for CNS diseases. Lead indications are SOD1, C9orf72-linked amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). Projects will include early stage research on genome editing for ALS, an IND-enabling study in non-human primates for a gene therapy candidate for ALS, and an IND-enabling study in non-human primates for a gene therapy candidate for HD.


Required Qualifications:


Applicants should have a PhD in biomedical sciences with a strong background in molecular biology and biochemistry, as well a track record in the field of ALS/CNS disorders (CNS Lead role) or liver diseases (Liver Lead role). Hands-on experience with relevant mouse models as well as excellent knowledge of CRISPR-based genome editing are required. Ability to work independently in a fast-paced research environment and multitask, be highly organized and adaptable are required. Strong writing, verbal and interpersonal skills are required.


Required skills:


• PhD degree in biomedical sciences

• track record in ALS/CNS disorders or liver diseases with at least two first author publications

• hands-on experience with genetic mouse models (CNS or liver)

• excellent knowledge of CRISPR-based gene editing

• excellent communicationj skills both oral and written are essential


Preferred skills:

• hands-on experience with CRISPR-based gene editing

• experience in next generation sequencing and bioinformatics

• experience in tissue culture, cytokine multiplex assays and ELISA


Additional Information:


Our lab is multicultural and supports personal development and work-life balance. Attractive salary and benefits available based upon relative working experience.


Worcester is located an hour away from Boston and offers a good quality of life with plenty or nearby outdoor activities and many restaurants.


Interested candidates please email CV to: Chris.Mueller@umassmed.edu


Apply Here: https://careers-umms.icims.com/jobs/28102/post-doctoral-associate-/login


Link: https://careers-umms.icims.com/jobs/28102/post-doctoral-associate-/login
Employer: University of Massachusetts Medical Center
Location: Worcester, MA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: May 31st, 2017
Applications close: July 29th, 2017
University of Massachusetts Medical CenterWorcester, MAPhDALSMay 31, 2017
Chair, Department of Neuroscience

Chair, Department of Neuroscience

(Click title to open job details in a new window.)
Description:

The UConn School of Medicine is seeking an outstanding neuroscientist at a rank of Associate or Full Professor to become Chair of the Department of Neuroscience. Candidates with nationally recognized accomplishments in research, sustained NIH or extramural funding, and leadership experience are encouraged to apply. Desired areas of expertise include but are not limited to cellular and molecular neuroscience, chronic and neurodegenerative diseases, brain circuitry research, and neurogenesis and regeneration. This position is ideal for an energetic individual with the leadership skills and vision required to foster the health and growth of a department that values academic excellence and collaboration. The departmental faculty excel in a variety of research areas

(neuroscience.uchc.edu), lead educational programs in the graduate, medical and dental schools, and provide a stimulating environment for research trainees.


Interested applicants should submit a cover letter indicating research interests, vision for the department and description of leadership style (maximum of 2 pages) with an up to date curriculum vitae in a single pdf file to the UConn Health Employment Services website (Search no. 2017-707)

https://jobs.uchc.edu. Please address questions to the search committee chair, Dr. Anthony Vella c/o Shelly Lombardo (neurosciencechair@uchc.edu). Applications will be accepted and reviewed until the position is filled.


Link: https://www.linkedin.com/jobs/view/355117116/
Employer: University of Connecticut School of Medicine
Location: Farmington, CT
Sector: Academia
Degree required: PhD or MD/PhD
Conditions: NDG
Job posted: May 28th, 2017
University of Connecticut School of MedicineFarmington, CTPhD or MD/PhDNDGMay 28, 2017
Lab Technician, Grinberg Lab

Lab Technician, Grinberg Lab

(Click title to open job details in a new window.)
Description:

The position is for a part time Lab Technician / Staff Research Associate I (SRA I) to assist the Principal Investigator (PI) in neuropathology research that investigates the pathogenesis of Alzheimer’s disease, frontotemporal dementia, and related disorders at UCSF Mission bay campus ( see http://grinberglab.ucsf.edu). The candidate is expected to be open to learning new methods.

The SRA I represents an excellent opportunity to further basic laboratory and research skills in a dynamic clinical neuroscience environment. The successful applicant will be an energetic, team player, self-directed learner with a keen interest in research.


Link: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?partnerid=6495&siteid=5226&jobId=2497141
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: BA/BS
Conditions: FTD
Job posted: May 26th, 2017
University of CaliforniaSan Francisco, CABA/BSFTDMay 26, 2017
Senior Research Investigator

Senior Research Investigator

(Click title to open job details in a new window.)
Description:

The Gene Therapy Program (GTP) and Orphan Disease Center (ODC) are entering a new era of unprecedented opportunity with great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases. Our R&D organization has a translational infrastructure that includes: technology discovery, specialized immunology assays operating under GLP, a Vector Core/Manufacturing unit that conducts GMP comparable work, and a large non-clinical program for animal testing under GLP including large NHP and rodent vivaria.


We are currently looking for Senior Research Investigator (SRI), Translational Research, to work in one of several therapeutic areas such as motor neuron, neurodegenerative, and/or therapeutic antibodies.

As a SRI, Translational Research, you will be involved in translation research projects in one or more therapeutic areas. In each case, you will be working in the setting of large interdisciplinary teams, where you will function independently in the execution of the experiments but will need to work collaboratively with other team members. Working independently, you will perform design, optimization and implementation of complex in vitro and in vivo experiments in rodents and NHP within specified timelines; provide cross-organizational support for the essential laboratory functions, including effective management of laboratory resources, and participation in maintenance of centralized reagents; contribute to writing/reviewing manuscripts, preparing presentations, establishing collaborations as well as writing/reviewing protocols and SOPs.


This position offers the opportunity to interface broadly internally & externally with diverse functional areas. Joining GTP offers scientific professionals the unique opportunity of seeing their research go from bench to bedside and discoveries that could one day lead to cures.

As a top candidate for this role, you will possess: Minimum of 5 years of experience after the completion of the PhD degree in the field of molecular biology, virology,biochemistry, enzymology, gene therapy, protein engineering, or related fields required.


Candidate must thrive in a team environment, have excellent written and oral communication skills, ability to prioritize in a fast-paced environment, and proficiency with standard methods of data analyses


Link: https://www.linkedin.com/jobs/view/308194466/
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: May 26th, 2017
University of PennsylvaniaPhiladelphia, PAPhDALSMay 26, 2017

Industry

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
Scientist I, ALS

Scientist I, ALS

(Click title to open job details in a new window.)
Description:

Neurology Research at Biogen seeks a highly motivated and experienced associate scientist to join the new initiative on ALS (amyotrophic lateral sclerosis). The Neurology department is responsible for discovery research on pathogenic mechanisms of neurodegenerative disorders and translating these findings into novel strategies for therapeutic intervention. The successful candidate will execute in vivo experiments to support the validation of novel drug targets and the development of small- and large-molecule drugs for the treatment of ALS. A major component of this work will be the assessment of drug candidates in a multiple rodent models, using a wide variety of morphological and functional endpoints, working closely with members of the ALS team as well as multiple internal and external collaborators. You will work in a fast paced, highly collaborative team environment at an exciting period for ALS research.


Qualifications

•Familiarity with genetic models of neurodegenerative diseases and experience with conducting either pharmacological or genetic tests in those models


•Must demonstrate a keen knowledge of experimental design, underlying scientific principles, and the ability to rigorously analyze and assess results and generate clear reports


•Previous experience handling animals is required and should include some of the following: dosing, dissection, and/or surgery


•Experience in histopathological techniques, such as perfusion, cryostat sectioning, immunostaining is strongly preferred


•Experience in molecular biology and biochemical techniques, such as DNA cloning, electrophoresis, and PCR is preferred


•Experience with behavioral or electrophysiological endpoints would be a positive addition


•Excellent communication and organizational skills are critical.


Link: https://jobs.biogen.com/job/Cambridge-Scientist-I%2C-ALS%2C-Neurodegeneration-and-Repair-MA-02138/418016000/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: ALS
Job posted: July 14th, 2017
BiogenCambridge, MAPhDALSJul 14, 2017
Scientist

Scientist

(Click title to open job details in a new window.)
Description:

As Scientist and critical member of the committed Neuro-Immunology team, you’ll help Alector discover and develop novel drugs targeting dementia and other neurological disorders. You will design and prioritize your own experiments and research endeavors to further Alector’s collective scientific understanding. In doing so you’ll apply your scientific insights to grow the company and guide its direction. Your work will be both inside and outside of the lab, and both strategic and hands-on. As an early hire, you’ll be influential in championing and developing Alector’s culture.


During The First Year, Your Goals Will Include:

*Independently leading a high-priority target discovery project from-end-to-end, from high-level design and planning to running experiments, assessing results and identifying the critical path forward to a fast go/no-go decision within a year of project start

*Being a great partner to both academic collaborators and contract research organizations to ensure successful joint efforts

*Collaborating within and across teams, including mentoring others on your areas of expertise so that they can learn from your relevant extraordinary skills

*Analyzing current scientific literature to help identify new targets or new strategies for existing targets

*Supporting ongoing projects based on your scientific knowledge and skills


We’d love to hear from you if:

*You enjoy finding creative and novel ways of thinking through scientific questions, and are an extraordinary critical thinker

*You take pride in being persistent, self-motivated, hands-on, and scrappy

*You demonstrate a track record of proficiency across a variety of techniques and instruments to seek answers to your scientific questions

*You have experience in several of: molecular biology, biochemistry, ELISA, flow cytometry, or in vivo mouse genetics

*Your academic background includes a PhD with 3+ years of postdoc research in a premier research lab (in neurobiology, neuroscience, neuro-immunology) or PhD+ 2 years of work in an industry setting

*You thrive in an environment where we work independently and on team

*You have strong points of view but are low ego

*Prior experience working with mouse models of neuro-degeneration and/or antibody discovery is a bonus.


Link: https://workable.com/j/C930FBE1A3
Employer: Alector
Location: San Francisco, CA
Sector: Industry
Degree required: PhD
Conditions: ALS, FTD
Job posted: July 10th, 2017
AlectorSan Francisco, CAPhDALS, FTDJul 10, 2017
Director of Clinical Operations

Director of Clinical Operations

(Click title to open job details in a new window.)
Description:

At Alector, we believe that neurodegeneration and dementia, are in fact immune disorders and we made it our mission to empower the immune system to cure Alzheimer’s disease, frontotemporal dementia, ALS and other degenerative brain conditions. We are supported by leading investors in healthcare including Orbimed, Polaris, Google Ventures and count some of the most innovative pharma companies as our strategic backers.


Use your hard-earned clinical and operational skills to help us achieve our exciting and important mission of saving lives by curing neurodegenerative diseases. As the Head of Clinical Operations (reporting to the Chief Medical Officer), you’ll lead the building of Alector’s clinical development operations capability. You will oversee all aspects of defining the clinical operations strategy, as well as successfully planning, executing, analyzing, and reporting on all of Alector’s clinical programs. You’ll be ensuring that these programs and goals are delivered on time, within budget and in compliance with Good Clinical Practices and laws and regulations. Over time, you will build a high-performing team of clinical professionals. You’ll be both strategic and hands-on, collaborating across Medical, Research, Development Science, CMC, and Finance teams to implement the Company’s clinical strategies and drive organizational success. As an early hire, you’ll be influential in championing and developing Alector’s culture.


Link: https://workable.com/j/16FC98B9EC
Employer: Alector
Location: San Francisco, CA
Sector: Industry
Degree required: MS; MBA preferred
Conditions: ALS, FTD
Job posted: July 1st, 2017
AlectorSan Francisco, CAMS; MBA preferredALS, FTDJul 01, 2017
Postdoctoral Fellow

Postdoctoral Fellow

(Click title to open job details in a new window.)
Description:

Sanofi’s Neuroscience Research Therapeutic Area based in Framingham, MA is looking for a highly qualified and motivated Postdoctoral Scientist to investigate the underlying disease biology of amyotrophic lateral sclerosis (ALS). The successful candidate will implement manifold in vitro and in vivo experimental approaches to help identify and validate innovative therapeutic targets for the treatment of ALS. These techniques include molecular biology, biochemistry, cell culture, immunoblotting, immunohistochemistry, microscopy, laser capture microdissection and the use of transgenic mouse models.


Responsibilities


Design and execute experimental strategies to understand the manner in which TDP-43 mislocalization contributes to ALS disease pathogenesis

Establish in vitro cell based models (astrocytes and motor neurons) of ALS

Conduct in vivo experimental work (clinical scoring, motor testing and tissue collection) using transgenic mouse models of ALS

Implementation of multiple state-of-the-art techniques in molecular biology, biochemistry, and microscopy

Analyze, interpret, and present experimental results at lab meetings.

Publish/present findings in peer-reviewed journals/scientific conferences.

Maintain accurate records of experiments and analyses.

Maintain lucid and effective communication with manager and other colleagues.


Basic Qualifications:


Ph.D. in Neuroscience or related field, with at 0-3 years of postdoctoral training

Previous first-author publication(s) in internationally recognized journals are required

Ability to meet aggressive timelines and deliverables in a collaborative environment

Excellent speaking, reading and writing skills

Strong analytical and organizational skills

Curiosity and a willingness to work independently

All candidates must have authorization to work in the United States throughout the duration of the Fellowship. No visa sponsorship will be provided


Link: https://jobs.sanofi.us/job/framingham/postdoctoral-fellowship-neuroscience-research/18104/4949481
Employer: Sanofi
Location: Framingham, MA
Sector: Industry
Degree required: PhD
Conditions: ALS
Job posted: June 21st, 2017
SanofiFramingham, MAPhDALSJun 21, 2017
Senior Associate Scientist, ALS and PD

Senior Associate Scientist, ALS and PD

(Click title to open job details in a new window.)
Description:

We are seeking a Research Senior Associate Scientist to join a vibrant and growing group currently focusing on Neurodegenerative diseases within the Neuroscience Therapeutic Area, a key component of the Discovery Research unit at Amgen’s site in Cambridge, MA (Amgen MAssachusetts-AMA). The successful candidate must be highly motivated with a deep interest in developing new and effective therapeutics for Parkinson’s disease (PD)/ALS.


Position Responsibilities

Conduct biochemical and cell-based experiments/assays to evaluate novel mechanisms and interrogate the biology of new therapeutic targets for PD/ALS

Carry out experiments required to rigorously evaluate in-licensing opportunities

Critically analyze and interpret data, and meet delivery deadlines

Work closely with and communicate results to multi-disciplinary and cross-functional teams

Execute high impact studies within an extremely fast-paced and collaborative environment


Link: https://careers.amgen.com/job/7265433/sr-associate-scientist-parkinsons-disease-als-cambridge-ma/
Employer: Amgen
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: ALS
Job posted: June 20th, 2017
AmgenCambridge, MABS or MSALSJun 20, 2017
Scientist I/II, NeuroImmunology

Scientist I/II, NeuroImmunology

(Click title to open job details in a new window.)
Description:

The Biogen Department of NeuroImmunology seeks a highly motivated and keen experimentalist whose primary responsibility is to advance drug discovery and development by performing bench research. The individual will be expected to design studies and execute research aimed at target discovery as well as the development of therapeutic approaches to treat acute neurological indications and chronic neurodegenerative diseases. The individual is expected to function independently and creatively within the context of project teams, drawing on pertinent literature, and to foster collaborations to maximize synergies and cross disciplinary approaches to advance the studies. The work will involve a wide array of in vitro and in vivo techniques and is expected to yield high quality publications.


Responsibilities include:


• Skilled experimentation; independent design, execution and analysis of experiments.


• Role as key contributor on project teams; collaborative conduct with internal and external investigators


• Development and delivery of effective presentations; ability to defend work. Preparation of high quality manuscripts, research project reports, or invention disclosures.


Link: https://jobs.biogen.com/job/Cambridge-Scientist-III%2CNeuroImmunology%2C-Research-and-Early-Development-MA-02138/406286600/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: June 8th, 2017
BiogenCambridge, MAPhDNDGJun 08, 2017
Electrophysiologist

Electrophysiologist

(Click title to open job details in a new window.)
Description:

The Musculoskeletal disease area research department at the Novartis Institutes for BioMedical Research (NIBR) in Basel, Switzerland, is looking for a Scientific Associate with excellent electrophysiology skills to join a highly motivated research team that aims to identify and develop therapies for neuromuscular diseases and peripheral neuropathies like amyotrophic lateral sclerosis and sarcopenia.


• You will be primarily responsible for conducting experiments using in vitro models for compound assessment and target validation

• You will have the chance to use your broad technical skills in cell and molecular biology techniques in addition to your core electrophysiology expertise

• You will independently design experiments and perform statistical evaluations

• Using your effective organizational skills you will contribute to experimental planning and the global maintenance of the laboratory

• This position offers the opportunity to work in a multi-disciplinary environment and to actively contribute to the discovery and development of new therapies for musculoskeletal diseases.


Link: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?partnerid=13617&siteid=5260&alcon&jobId=2486513
Employer: Novartis Pharma AG
Location: Basel, Switzerland
Sector: Industry
Degree required: BS or MS
Conditions: ALS
Job posted: May 24th, 2017
Novartis Pharma AGBasel, SwitzerlandBS or MSALSMay 24, 2017
Neurobiology Research Associate II

Neurobiology Research Associate II

(Click title to open job details in a new window.)
Description:

Verge Genomics is seeking a Neurobiology Research Associate II to join the Drug Discovery team. This candidate will gain pharmaceutical industry experience in a cutting-edge academic lab in the SF Bay Area and at Verge Genomics headquarters in SF. The candidate will be part of a multifunctional team with responsibility for target validation and evaluation of novel drug candidates for neurodegenerative diseases. The candidate will conduct in vivo studies in mice, including neonatal intracerebroventricular injections, and drug administration by oral routes. Experience with stereotaxic surgery, gene therapy (AAV9 or ASO), behavioral observations, gait analysis, rotarod and grip strength, and genotyping are a plus. The ideal candidate will have excellent problem-solving skills and familiarity with statistical analysis. This position reports to a PhD Scientist. The candidate will also culture motor neurons differentiated from induced pluripotent human stem cells and aid in the design and development of cellular assays to identify genes and compounds for treating neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). The candidate will have extensive experience with sterile in vitro laboratory tasks, including harvesting, storing, growing, and expanding neuronal cultures, formulating and adding compounds and molecular probes, measuring cell numbers with light microscopy and properties based on immunohistochemical markers, and writing SOPs and detailed records of all work.


Link: https://www.linkedin.com/jobs/view/350934360/
Employer: Verge Genomics
Location: San Francisco, CA
Sector: Industry
Degree required: BS or MS
Conditions: ALS
Job posted: May 24th, 2017
Verge GenomicsSan Francisco, CABS or MSALSMay 24, 2017
Scientist, Neurological Rare Disease

Scientist, Neurological Rare Disease

(Click title to open job details in a new window.)
Description:

Sanofi’s Neuroscience Research Therapeutic Area based in Framingham, MA is looking for a highly qualified and motivated Scientist to develop therapies for rare neurologic and neurodegenerative diseases. This laboratory based position will include the opportunity to lead project teams and interact with internal and external functions to initiate new drug discovery programs and advance ongoing projects. The candidate will use epigenetics tools, genome editing technologies, –omics, bioinformatics and other approaches to identify and validate new targets. The candidate will also advance understanding of the role of the non-coding genome to identify and validate innovative and transformative therapies for rare neurologic diseases.


Link: https://sanofi.wd3.myworkdayjobs.com/en-US/Sanoficareers/job/Framingham-MA/Scientist--Neurological-Rare-Disease_R1267-1
Employer: Sanofi
Location: Framingham, MA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: May 24th, 2017
SanofiFramingham, MAPhDNDGMay 24, 2017

Non-Profit and Government

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
Share this:
Facebooktwittergoogle_plusmailFacebooktwittergoogle_plusmail