Figure 3. Expression of oligodendrocyte-specific cell type markers in F3.Olig2 cells and expression of motor neuron-specific cell type markers in F3.Olig2-Shh cells.
Image credit: Lee, et.al. 2014 under CC BY license

Job Opportunities

To submit any new job opportunities for this list, please email ALSjobs@prize4life.org. List the employer, location, closing date if applicable, and a link to more information. Jobs are removed after 3 months, unless requested otherwise.

This free job bulletin board aims to help scientists identify job opportunities in the field of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Positions described as broadly spanning neurodegenerative diseases (NDG) are noted as ‘NDG‘. The job listing includes research positions at all levels, as well as non-research positions for which a research background at the MS, PhD, or MD level is required.


Click the title of any table column to sort.

Academia

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Assistant Professor, Cell and Molecular Biology

Assistant Professor, Cell and Molecular Biology

(Click title to open job details in a new window.)
Description: The George and Anne Ryan Institute for Neuroscience and the Department of Cell and Molecular Biology invite applications for the position of Assistant Professor.

The successful candidate will have an appointment in the Department of Cell and Molecular Biology (CMB) in the College of the Environment and Life Sciences. The candidate will be expected to establish a basic science or translational research program in an area that complements the mission of the Ryan Institute and the Department of Cell and Molecular Biology, and is supported by extramural funding. The successful candidate will also contribute to the University’s teaching mission and participate in service activities.

The Ryan Institute is an interdisciplinary research institute that is focused on discovering and developing disease-modifying therapies for neurodegenerative diseases. CMB is a research and teaching department focused on the cellular and molecular basis of physiology and disease. We are building a faculty with a strong record of successful laboratory and/or clinical research that support our mission of integrating discovery science, translational medicine, education and community engagement to identify and deliver tomorrow’s treatments today.

Responsible for managing and maintaining the COP Heber Youngken Medicinal Garden including plants in Avedisian Hall, COP assigned greenhouse(s), and surrounding COP courtyard environs. Lead students, faculty, and garden volunteers to enable use of Medicinal Garden for research, teaching, public education and outreach.

Visit the URI jobs website at: https://jobs.uri.edu  to apply and view complete details for job posting (F00087).  Please attach the following 3 (PDF) documents to your online Faculty Employment Application:  (#1) Cover letter including a description of how your qualifications match the requirements for the position, (#2) Curriculum Vitae, which should include the names and contact information for three professional references, and (#3) “Other Document” a research statement or sample(s) of relevant scholarly work (as one complete document).

Application Deadline:  This is an open until filled search. First consideration will be given to applications received by June 17, 2018.

Link: https://neurojobs.sfn.org/jobs/11056889/asst-professor-the-george-and-anne-ryan-institute-for-neuroscience-and-cell-and-molecular-biol
Employer: University of Rhode Island
Location: Kingston, RI
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 16th, 2018
University of Rhode IslandKingston, RIPhDNDGMay 16, 2018
NEW! Bioinformatics Specialist

Bioinformatics Specialist

(Click title to open job details in a new window.)
Description:

The VIB-KU Leuven Center for Brain & Disease Research is seeking a highly motivated Single Cell Bioinformatics Specialist. You will collaborate with the 17 research groups within the Center and provide essential input on computational biology aspects of their research projects. In this job you will be confronted with exciting research questions in neurobiology and neurodegeneration; and with a broad spectrum of computational challenges and single-cell omics data sets. You will work closely with in the Laboratory of Computational Biology (Stein Aerts Lab) and with the single cell expertise unit (Suresh Poovathingal) and you will be part of an active bioinformatics community in Leuven, allowing daily interactions with colleague bioinformaticians.


For additional information concerning this job please contact Prof. Stein Aerts.


To apply,  submit your application to our website. Please include in your application your CV (including a list of your scientific publications, and the names and contact information of 3 references) as well as a cover letter describing your motivation, previous research experience and background. Please provide also a track record of previous coding work, e.g. include your github web address.


Link: https://vibvzw.jobsoid.com/j/11971/single-cell-bioinformatics-specialist
Employer: VIB
Location: Leuven, Belgium
Sector: Academia
Degree required: MSc or PhD
Conditions: NDG
Job posted: May 16th, 2018
VIBLeuven, BelgiumMSc or PhDNDGMay 16, 2018
NEW! Principal Scientist

Principal Scientist

(Click title to open job details in a new window.)
Description:

Purpose:


This person will work closely with members of the R&D organization, CROs, consultants, corporate collaborators as well as the senior leadership team to ensure development and execution of drug discovery projects according to company goals. This person will report to the SVP of Translational Sciences.


Essential Job Responsibilities:



  • Lead drug discovery programs using both internal and external (CRO, academia) resources

  • Mentor junior scientists in project leadership in a matrix environment

  • Provide scientific and strategic input into the company’s target pipeline and best disease indication selection


Quantitative Dimensions:



  • Lead all aspects of drug discovery project(s) using internal and external resources

  • Proactively identify critical-path project goals, activities, and constraints, propose mitigation plans when necessary

  • Direct, motivate and hold accountable to goals and timelines all internal and external team members associated with the project

  • Effectively communicate project status, changes to plan and risks to senior leadership team

  • Contribute in identifying the most relevant external resources for the project

  • Contribute to strategies that advance projects from early stage to IND and clinical development

  • Contribute to the company’s scientific strategy


Qualifications:


Required



  • PhD degree in pharmacology, biology, molecular biology, biochemistry, or related field

  • At least 8 years of experience in a drug discovery setting (biotech or large pharma)

  • Prior experience in leading drug discovery projects from lead discovery to IND

  • Exceptional demonstration of scientific leadership and strategy, track record of leading value-creating accomplishments, external recognition of scientific leadership in translational setting

  • Excellent written and oral communication skills

  • Ability to work productively in a collaborative and cross functional team environment within and outside of Mitobridge


Preferred



  • Experience in areas such as muscle, kidney, metabolic, neurodegenerative diseases, rare diseases and/or mitochondrial biology

  • A great sense of urgency and ownership for moving projects efficiently forward

  • Experience with due diligence of business development opportunities in early and late stage programs


Link: https://astellascareers.jobs/cambridge-ma/principle-scientist-research-fellow/8FE07F4785A848658683CC64D5A32259/job/?
Employer: Astellas Pharma
Location: Cambridge, MA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 16th, 2018
Astellas PharmaCambridge, MAPhDNDGMay 16, 2018
NEW! Research Specialist

Research Specialist

(Click title to open job details in a new window.)
Description:

A Lead Research Specialist position is available in the Center for Neurodegenerative Disease to join a dynamic research environment that uses a wide range of techniques and technologies to study neurodegenerative disease (e.g., Alzheimer’s disease, amyotrophic lateral sclerosis) pathogenesis. The successful applicant will be self-motivated and capable of working both independently and as a member of a team. Responsibilities will include assisting with the procurement and banking of human autopsy brain specimens and with distribution of tissue and biospecimens to investigators. He/she will also share responsibility for histological and immunohistochemical staining of human and rodent tissues. The successful applicant will be familiar with and train users in the proper use of shared laboratory equipment, and will share responsibility for maintaining the laboratory, including monitoring the storage and disposal of hazardous substances, ordering supplies, calibrating and performing routine repair and maintenance of equipment, interfacing with service personnel for equipment repairs, and maintaining and documenting laboratory safety standards. Upon hiring, the employee must complete the Laboratory Safety Training class and undergo immunization against potentially hazardous agents, as required by Emory University policy. Basic computer experience (Microsoft Word, Excel, etc.) and strong organizational and record-keeping skills are essential. Experience with Western blotting, confocal microscopy, tissue sectioning, histology and/or immunohistochemistry is highly desirable.


Link: https://staff-emory.icims.com/jobs/20322/research-specialist%2c-lead/job?hub=13&mobile=false&width=1150&height=500&bga=true&needsRedirect=false&jan1offset=-300&jun1offset=-240
Employer: Emory University
Location: Atlanta, GA
Sector: Academia
Degree required: BS
Conditions: ALS
Job posted: May 15th, 2018
Emory UniversityAtlanta, GABSALSMay 15, 2018
NEW! Postdoctoral Fellow, Zhang Lab

Postdoctoral Fellow, Zhang Lab

(Click title to open job details in a new window.)
Description:

Postdoctoral positions are available at the University of Wisconsin-Madison to study neural stem/progenitor cell self-renewal /reprogramming and functional dissection / therapeutic implication of human neural cells in neurological disorders. PhD or equivalent in cell / molecular / developmental biology, neuroscience, or chemistry is required. Experiences in electrophysiology, small animal microsurgery, genome editing, or 3D printing are highly desirable. Compensation follows the NIH standard. The Zhang laboratory is a leading group studying neural specification of human pluripotent stem cells and application of stem cells in developing therapeutics for neurological diseases (e.g., Cell Stem Cell, 2014, 2015, 2016, Nature Biotechnology, 2016, Nature Medicine, 2016, Nature Communication, 2017, Stem Cell Reports 2017/18). It is located in the NIH-sponsored Waisman Center that is dedicated for studying human development, developmental disability, and neurodegenerative diseases. Candidates enthusiastic in pursuing regenerative sciences are welcome to join this vibrant group in the beautiful city of Madison.


Link: https://www.nature.com/naturejobs/science/jobs/644297-postdoctoral-positions-in-stem-cells-and-neural-regeneration
Employer: University of Wisconsin
Location: Madison, WI
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: May 14th, 2018
University of WisconsinMadison, WIPhDALSMay 14, 2018
NEW! Bioinformatics Specialist

Bioinformatics Specialist

(Click title to open job details in a new window.)
Description:

A Bioinformatics Staff Scientist position is available at the DZNE in Tübingen within the scientific team “Genome Biology of Neurodegenerative Diseases” led by Prof. Peter Heutink. The research focus of our group is to identify genetic risk factors for neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Frontal-Temporal Dementia/Motor Neuron Disease, Progressive Supranuclear Palsy and Ataxia in close collaboration with our clinical partners. As partners in the International Parkinson’s Disease Genomics Consortium (IPDGC) (http://pdgenetics.org/), we participate in large scale genetic and genomic studies to identify new genetic risk factors and to characterize the biological consequences of these mutations and risk factors by using automated high-throughput cellular screens combined with genomic and transcriptomic approaches. For further details on the scientific program of the group, please refer to http://www.dzne.de/en/sites/tuebingen/research-groups/heutink.html.


To apply, submit your application online: https://jobs.dzne.de/en/jobs/184/form .


Link: https://www.nature.com/naturejobs/science/jobs/644277-bioinformatics-staff-scientist-f-m
Employer: German Center for Neurodegenerative Diseases (DZNE)
Location: Tübingen, Germany
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: May 13th, 2018
German Center for Neurodegenerative Diseases (DZNE)Tübingen, GermanyPhDALS, FTDMay 13, 2018
NEW! Graduate Studentship, Locker Lab

Graduate Studentship, Locker Lab

(Click title to open job details in a new window.)
Description:

Alzheimer’s disease (AD), Parkinson’s disease (PD) and Amyotrophic lateral sclerosis (ALS) areneurodegenerative disorders (NDs) with proteostasis defects. They represent an ideal set of diseases covering >70% of patients to increase our understanding of the molecular basis of NDs. The associated pathologies are difficult to truly model and compare using animals because (i) they are mainly caused by sporadic forms of the diseases, and (ii) models do not recapitulate the basic cellular changes observed in patients. Our aim is to achieve a global understanding of RNA translation and stress granules regulation across these neurodegenerative diseases using novel genetically engineered isogenic human stem cell lines. This will identify key regulatory nodes, across diseases, revealing new points for therapeutic interventions.The PhD candidate will work as part of an EU/MRC-funded trans-national consortium that has developed control fibroblasts genetically engineered into disease cell lines (project grant MR/R02426X/1), allowing studies within identical genetic backgrounds. Following training with our project partners at McGill (Canada) and QMUL (UK), the control and disease-model iPSCs will be used to differentiate neuronal cell populations including forebrain cortical-like neurons, midbrain dopamine-like and glial astrocyte-like cells. Subsequently, the candidate will be trained in confocal microscopy techniques to detect and quantity stress granules in cells, measure translational activity globally and specifically at the mRNA level using ribosomes profiling.


Applicants are expected to hold a good honours degree (upper second) in an appropriate discipline, but prior experience in research or industry may be acceptable. Enthusiasm for, and commitment to, independent study is essential.


The appointed candidate will supported by a Medical Research Council grant (MR/R02426X/1: £310.088,70) awarded to N.Locker , for 3 years of PhD studies within which the candidate is expected to submit their PhD thesis. The studentship rates and minimum doctoral stipend will align to UKRI guidelines as follows: stipend for 2017/18 is £14,553; fee 2017/18 is £4,195. This will also cover bench fees associated with the projects, small equipment, travels for training purpose and conference attendance.


For further details and an informal discussion please contact Dr Nicolas Locker at n.locker@surrey.ac.uk prior to submitting an application. Formal applications should be submitted through our Biosciences and Medicine programme page. You should make clear in your application that you are applying for this studentship. You should also submit a cover letter stating that you are a UK/EU national and willing to go through the required security vetting process.


Link: https://jobs.surrey.ac.uk/vacancy.aspx?ref=035218
Employer: University of Surrey
Location: Guildford, England
Sector: Academia
Degree required: BS
Conditions: ALS
Job posted: May 11th, 2018
University of SurreyGuildford, EnglandBSALSMay 11, 2018
NEW! Group Leader, Neurobiology

Group Leader, Neurobiology

(Click title to open job details in a new window.)
Description:

The Neurobiology Division of the Medical Research Councils Laboratory of Molecular Biology (MRC LMB) invites applications for a Programme Leader-Track position.   We seek a scientist with a focus on the elucidation of fundamental molecular mechanisms that determine the structure and function of the neuronal synapse, in health and disease.  An emphasis on the development and application of molecular neurobiological approaches is essential, and the application of cutting-edge light and/or electron microscopic imaging is encouraged.  The primary selection criteria are scientific excellence and potential for synergy with our existing research programmes, both within the Division (encompassing neuronal molecular cell biology, neural circuits and simple behaviours, and the molecular/ cell biological basis of neurodegeneration) and across the wider LMB.  You should hold a PhD and have an excellent publication record, be internationally recognised for your work and have outstanding potential for independent research.


The position comes with substantial core funding sufficient to establish your research group, and applications for additional external grant support are encouraged.  The LMB has an exceptional record of ground-breaking research, and in 2013 moved into a new building with outstanding core facilities including those for light and electron microscopy and mass spectrometry, as well as electronic and instrumentation workshops.  Administrative duties are minimal and no teaching is required.  Interactions across the four Divisions of the LMB are encouraged.  The University of Cambridge and affiliated institutions form a vibrant Neuroscience community (http://www.neuroscience.cam.ac.uk/).


The appointment will be made at Programme Leader-Track level, and candidates should have a strong international track record of relevant independent research and an ability to lead a research team, pursuing original approaches to long-term research goals.


Find out more about the LMB’s Neurobiology Division at http://www2.mrc-lmb.cam.ac.uk/research/neurobiology/.  Informal enquiries can be addressed to Head of Division, Michael Hastings (mha@mrc-lmb.cam.ac.uk).  For further information about the MRC visit www.mrc.ac.uk


To apply, submit your application online.  Applications should include a covering letter and full CV, an outline of current research interests (1 page) and a proposal for future research (up to 2 pages), along with the names and addresses of three professional referees who have agreed to be contacted prior to interview.


Link: https://mrc.tal.net/vx/mobile-0/appcentre-ext/brand-3/candidate/so/pm/4/pl/1/opp/834-Programme-Leader-Track-Neurobiology-Dr-Michael-Hastings-LMB-834/en-GB
Employer: UKRI MRC Laboratory of Molecular Biology
Location: Cambridge, England
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 10th, 2018
UKRI MRC Laboratory of Molecular BiologyCambridge, EnglandPhDNDGMay 10, 2018
NEW! Research Technologist, Morrison and Rothstein Labs

Research Technologist, Morrison and Rothstein Labs

(Click title to open job details in a new window.)
Description: A Research Technologist to work in the laboratories of Drs. Brett Morrison and Jeffrey Rothstein in the Department of Neurology. Our laboratories study the pathogenesis of the devastating motor neuron disease, amyotrophic lateral sclerosis (ALS; commonly referred to as Lou Gehrig’s disease). A particular focus is on the role played by oligodendrocytes, a key support cell in the brain that is dysfunctional and degenerates in ALS.

Specific duties & responsibilities:

The responsibilities of the individual in this position will be to independently pursue new projects as well as work collaboratively with the other members of the lab (principal investigators, post-docs, graduate students, and research technicians) on ongoing projects. In addition to performing laboratory experiments, ongoing responsibilities will include the management of a transgenic mouse colony, assisting the laboratory manager with the ordering of laboratory supplies, and attending all required laboratory meetings.

Link: https://jobs.jhu.edu/job/Baltimore-Research-Technologist-MD-21205/437413200/
Employer: Johs Hopkins University
Location: Baltimore, MD
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: May 10th, 2018
Johs Hopkins UniversityBaltimore, MDBA or BSALSMay 10, 2018
Neurologist

Neurologist

(Click title to open job details in a new window.)
Description:

The Peripheral Nervous System, Muscle and ALS Department, Pasteur 2 new Hospital, CHU de Nice (France) is actually seeking a Neurologist with immediate availability for a Clinical and Research position. This department is certified as Neuromuscular Diseases Reference Center and ALS Reference Center. These Centers are affiliated to French rare diseases Healthcare Network (FILNEMUS) and French rare diseases Healthcare Network: Amyotrophic lateral sclerosis and rare motor neuron diseases (FILSLAN). The Department has also been labeled as being part of the European Reference Networks-NeuroMuscular Diseases (ERN-NMD) as Center of Excellence.


With an active file of more than 2000 patients, the department is particularly involved in diagnosis and multidisciplinary care of patients suffering from myopathies, myasthenia, peripheral neuropathies and ALS. This activity implies consultations, day and week hospitalizations sectors. It is composed of an electrophysiology platform and possesses the necessary means for the performance and the analysis of muscle or nerve biopsies. The Physicians from the Department are particularly involved in Clinical and Fundamental Research projects in connection with IRCAN from the University of Nice- Sophia Antipolis- Faculty of Medicine, INSERM U1081 – CNRS UMR 7284 and INRIA. We participate in industrial Therapeutic Trials.


The Department is part of the Pole of Clinical Neurosciences, Central Nervous System department and the Neurovascular Unit which are located in the same Hospital. It contributes to ensure the continuity and constant care of patients suffering from neurologic diseases.


The required skills for application are the following:


*Having a Medical Doctor Thesis and possessing a Diploma of specialty in Neurology which is recognized in France

*Being fluent in French (oral and written) and in English.

*Having an overall knowledge of neuromuscular pathologies especially in peripheral nerve ones and being able to ensure a diagnostic activity and electrophysiological diagnosis. (ENMG).

*Candidates having knowledge and or diploma justifying their expertise in Neuromuscular diseases field (clinical, electrophysiology) will be considered in priority.


Dynamism and willingness of being involved in Research projects will be highly appreciated qualities.


Interested candidates will beforehand contact Pr Sacconi- Head of Department. They will send their CV containing their Title and works, and a cover letter in French .


Pr Sabrina SACCONI


Système Nerveux Périphérique, Muscle et SLA

Hôpital Pasteur 2, Avenue voie Romaine,

06001 Nice cedex 01, France

email : sacconi.s@chu-nice.fr,

Téléphone : +33 (0)492 03 5757


Link: https://en.academicpositions.fi/ad/chu-de-nice/2018/neurologist-with-immediate-availability-for-a-clinical-and-research-position/112120
Employer: Centre Hospitalier Universitaire de Nice
Location: Nice, France
Sector: Academia
Degree required: MD
Conditions: ALS
Job posted: May 5th, 2018
Centre Hospitalier Universitaire de NiceNice, FranceMDALSMay 05, 2018
Postdoctoral Fellow, Baker Lab

Postdoctoral Fellow, Baker Lab

(Click title to open job details in a new window.)
Description:

You will contribute to a major new project, funded by the William Leech Charity, to generate a primate model of motor neuron disease. Click here for further details.


You will be responsible for the day-to-day running of the project, gathering electrophysiological and imaging data. You will perform computational analysis of the data, and will produce the first draft of manuscripts to publish the results. A PhD in Neuroscience or related discipline is essential, and experience with primate electrophysiology, MRI, and writing MATLAB scripts for data analysis would be an advantage.


Salary: £29,799 to £31,604 per annum.


Excellent team skills are required to liaise with the many staff members with roles in this project, and a strong commitment to animal welfare and 3Rs.


The post is tenable until the end of March 2021.


Informal enquiries to stuart.baker@ncl.ac.uk.


 


Link: https://vacancies.ncl.ac.uk/ViewVacancyV2.aspx?enc=mEgrBL4XQK0+ld8aNkwYmPgqa2Bp8pKqUS0pcNJvPheq+F+nQpHjpgLFPSxGTB+fOXxJTqYeWpcpBRlocM7s+5d2grqSaU7XcU8wUruEjst66FGyfB/K9AaxsyS8w+qz5qWCjFbmsz5xSVTvz8EVUw==
Employer: Newcastle University
Location: Newcastle Upon Tyne, England
Sector: Academia
Degree required:
Conditions: ALS
Job posted: May 4th, 2018
Applications close: May 18th, 2018
Newcastle UniversityNewcastle Upon Tyne, EnglandALSMay 04, 2018
Postdoctoral Fellow, Liachko lab

Postdoctoral Fellow, Liachko lab

(Click title to open job details in a new window.)
Description:

A postdoctoral research position is available in the Liachko lab located at the Veterans Affairs hospital in Seattle, and affiliated with the University of Washington (http://depts.washington.edu/geront/directory/bios/liachko.html). We use model systems including mouse primary neurons, cultured human cells and C. elegans, to study the neurodegeneration seen in amyotrophic lateral sclerosis, Alzheimer’s disease, and other aging related disorders.


We are seeking a motivated post-doctoral fellow who works well with others as part of a research team. The ability to design, conduct, and report on research experiments is required. Communication skills, organizational skills, and a willingness to learn new approaches are of paramount importance. The fellow will pursue the underlying causes of aging associated protein aggregation in neurodegenerative disease using primary neuron, cell culture, and/or transgenic C. elegans models.


Knowledge/ Skills necessary:



  • Strong problem solving skills

  • Knowledge of genetics and/or neurobiology

  • Ability to design and execute controlled experiments

  • Effective communication with internal and external researchers

  • Reporting of research findings

  • Aptitude for effective scientific writingDesirable Experience/Skills


Desirable Experience/Skills:



  • Experience with cell culture, microscopy, and immunoblotting.

  • Familiarity with transgenic mice and/or C. elegans

  • Competence in microbiology and molecular cloning


Requirements: A PhD in the biomedical science, the ability to fulfill responsibilities listed above, and eligibility and willingness to apply for external postdoctoral funding including T32/F32 NIH training grants or other independent funding sources. Self- motivation is essential


Salary: $66,000.00 to $79,000.00 /year


Link: https://www.indeed.com/q-Post-Doctoral-Research-Associate-jobs.html?vjk=feb8c4a6e38047c3
Employer: VA Hospital
Location: Seattle, WA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: May 3rd, 2018
VA HospitalSeattle, WAPhDALSMay 03, 2018
Postdoctoral Fellowship

Postdoctoral Fellowship

(Click title to open job details in a new window.)
Description:

The European Bioinformatics Institute (EMBL-EBI), the NIHR Cambridge Biomedical Research Centre (BRC) and the University of Cambridge School of the Biological Sciences (SBS) are now accepting applications for joint postdoctoral fellowships, supporting projects that apply computational approaches to translational clinical or biological research.


EBPOD fellowships support three-year projects supervised jointly by faculty members at EMBL-EBI and either the Cambridge BRC or the University of Cambridge’s School of the Biological Sciences.


We are looking for self-directed, focused scientists with a profound interest in clinical or translational research, who enjoy working through a problem computationally. We offer an opportunity to apply your skills and energy for the greater good, working in one of the world’s most outstanding research environments.


For full information on the EBPOD fellowships please click here


Project details

Project 1: Elucidation of Regulatory Elements Underlying Astrocyte-neuron Interactions in Human Models of Motor Neurone Disease


For full on this project please click here


Application Instructions

Applications should consist of the following:


1. A cover letter specifying the project you are applying for (see the list on this page);

2. Your curriculum vitae;

3. Two recent letters of reference.


The deadline for submission of the online application and self-proposed projects is Friday, 20 July 2018 (23:00 BST)


Link: https://www.embl.de/jobs/searchjobs/index.php?ref=EBI_01198&newlang=1&srch_trm=EBPOD%20Fellowship:
Employer: European Molecular Biology Laboratory
Location: Hinxton, England
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: May 1st, 2018
Applications close: July 20th, 2018
European Molecular Biology LaboratoryHinxton, EnglandPhDALSMay 01, 2018
Physician, Physical Medicine & Rehabilitation

Physician, Physical Medicine & Rehabilitation

(Click title to open job details in a new window.)
Description:

The ideal candidate would be preferably Physical Medicine & Rehabilitation (PM&R), Spinal Cord Injury/Dysfunction fellowship-trained. Experience in Spinal Cord Injury-Disability (SCI-D), Spinal Cord Injury (SCI), Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), PM&R. Board Certified/Board Eligible in SCI is preferred. Candidates with board certification or board eligibility in SCI are eligible to apply regardless of residency specialization, and will be given preference in the application, but fellowship is not exclusively required if residency training is in PM&R.


Link: https://www.vacareers.va.gov/job-search/job-detail.asp?job=324576
Employer: Veterans Affairs
Principal investigator: Veterans Health Administration
Location: St. Louis, MO
Sector: Academia
Degree required: MD
Conditions: ALS, SCI
Job posted: April 29th, 2018
Veterans AffairsSt. Louis, MOMDALS, SCIApr 29, 2018
Research Associate, Svendsen Lab

Research Associate, Svendsen Lab

(Click title to open job details in a new window.)
Description:

The Svendsen Laboratory at Cedars-Sinai Medical Center, Regenerative Medicine Institute is looking personnel to join our dynamic group. The ideal incumbent should have experience in managing and analysis of large datasets using programming languages such as Python and R, and an interest in working hands on with stem cells and organ-on-chip technology with a focus on research in neurodegenerative diseases (Brain-on-Chip). Ideal candidate will also have experience in machine learning approaches for use in automation of laboratory equipment and analysis of complex bioinformatic datasets. Working with the PI and scientists, the Research Associate I (RA I) performs a variety of routine experimental protocols and procedures to support the objectives of one or more laboratory research projects in a specific area of research, including the Brain-on-Chip program. RA I is responsible for the generation and curation of acquired data, implementation of analysis programs, and generation of scripts to assists in laboratory activities and research aims. RA I is responsible for general laboratory activities including maintenance of reagents, ordering and stocking of supplies. RA I keeps accurate and detailed records of experiments and results. RAH assists in the operation of specialized equipment and machinery, including the culture of human stem cell derived tissues. Observes safety standards and procedures. This position may include supervisory responsibilities. Daily Duties will include the following: – Performs a variety of routine laboratory tasks and procedures. – Works with laboratory staff to develop and implement analysis frameworks for use in biomarker and therapeutic target discovery – Keeps accurate and detailed project records of experiments and results. – Maintains lab equipment and related records. – Transports, processes and logs samples. – Maintains computer database with relevant information – implements scripts for the analysis of complex imaging and multi-omic analysis datasets. – Performs lab maintenance duties, including glassware cleaning and sterilization, – Maintains stocks of general lab materials, and places orders for lab equipment and supplies. – Assists new students and fellows at the laboratory. – Assists in the operation of specialized equipment and machinery. – Observes and complies with safety standards arid procedures. – Histology and Microscopy – Sectioning of tissue specimens – Staining of tissue specimens to include special stains and INC. Additional Information: Scheduling flexibility including evening, weekend and holiday rotation commitment is required. Travel may be required.


Link: https://main.hercjobs.org/jobs/10986710/research-associate-i-stem-cells
Employer: Cedars-Sinai Medical Center
Location: Los Angeles, CA
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: April 28th, 2018
Cedars-Sinai Medical CenterLos Angeles, CABA or BSALSApr 28, 2018
Postdoctoral Fellow, Ferraiuolo and El-Khamisy Labs

Postdoctoral Fellow, Ferraiuolo and El-Khamisy Labs

(Click title to open job details in a new window.)
Description:

Applications are invited for the post of Postdoctoral Research Associate in the laboratories of Dr Ferraiuolo and Prof

El-Khamisy, in a vibrant and stimulating environment at the Sheffield Institute for Translational Neuroscience (SITraN) and

Molecular Biology and Biotechnology (MBB). We are seeking a highly motivated scientist to join an exciting new project at the

translational medicine interface in motor neuron disease (MND) research also known as Amyotrophic Lateral Sclerosis (ALS).

You will be a practically skilled, well-organised, ambitious and committed Postdoctoral Researcher who will join the teams led

by Dr Ferraiuolo and Prof El-Khamisy in an exceptional collaboration with AstraZeneca (AZ).


Your project, funded through the AZ Postdoctoral Programme, aims to investigate the role of astrocytes derived from MND

patients in inducing DNA damage in motor neurons. You will be working in a semi-independent fashion, under the direction of

the principal investigators and the AZ team. You will be expected to: design, execute and evaluate experiments; keep excellent

experimental records; prepare reports regularly for AZ. You are also expected to contribute to the preparation of scientific

manuscripts, attend and deliver seminars and supervise a post-graduate student who will be working alongside you on a

related project.


You will have a strong background in molecular and cellular (neuro) biology with experience in a range of molecular and

cellular biology techniques, particularly cell based assays in human reprogrammed cells. You will also hold a PhD (or have

equivalent experience) in molecular or cellular biology, or neuroscience.


Link: https://jobs.shef.ac.uk/sap/bc/webdynpro/sap/hrrcf_a_posting_apply?PARAM=cG9zdF9pbnN0X2d1aWQ9MkQ5RkQ5OUM1NDI1MUVFODkyOTJERTc1QzExOTEyOTMmY2FuZF90eXBlPUVYVA%3d%3d&sap-client=400&sap-language=EN&sap-accessibility=X&sap-ep-themeroot=%2fSAP%2fPUBLIC%2fBC%2fUR%2fuos#
Employer: University of Sheffield
Location: Sheffield, England
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: April 27th, 2018
Applications close: May 28th, 2018
University of SheffieldSheffield, EnglandPhDALSApr 27, 2018
Research Technician

Research Technician

(Click title to open job details in a new window.)
Description:

The laboratory is seeking a motivated and enthusiastic candidate with experience in stem cell culture and molecular biology to support preclinical studies related to Amyotrophic Lateral Sclerosis (Lou Gehrig’s Disease) and pain. Working independently under the direction of the Principal Investigator, the research technician will assist in ongoing translational studies. The major responsibilities will include stem cell culture and differentiation, as well as general molecular biology techniques such as immunohistochemistry, RNA isolation and PCR to analyze the cells of interest. Additional work will include assistance with ordering, laboratory maintenance and animal husbandry.


Link: https://partners.taleo.net/careersection/ex/jobdetail.ftl?job=3063589&lang=en
Employer: Massachusetts General Hospital
Location: Charlestown, MA
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: April 27th, 2018
Massachusetts General HospitalCharlestown, MABA or BSALSApr 27, 2018
Research Assistant

Research Assistant

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Description:

The Rockefeller University seeks a Research Assistant to join Laboratory of Molecular Biology. The Research Assistant will contribute to a project examining the molecular mechanisms of neurodegenerative and psychiatric disorders. The Research Assistant will be responsible for performing molecular techniques, including TRAP, RNA-seq, in situ hybridization, and immunohistochemistry, to examine cell type specific gene expression profiles in the mouse brain. Will complete rodent surgeries, behavioral assays, and functional imaging of brain immunohistochemistry. Will be responsible for maintaining genetically altered mouse lines and completing other routine laboratory duties as needed.


Bachelor’s degree in science required; educational emphasis in neuroscience preferred. Must have experience with basic molecular biology techniques, fluorescent imaging, and handling laboratory animals. Must have computer skills and be proficient in Microsoft Excel. Must be organized, have excellent communication skills, and keep clear, accurate records.


Link: https://main.hercjobs.org/jobs/10965886/research-assistant
Employer: Rockefeller University
Location: New York, NY
Sector: Academia
Degree required: BA or BS
Conditions: NDG
Job posted: April 21st, 2018
Rockefeller UniversityNew York, NYBA or BSNDGApr 21, 2018
Assistant or Associate Professor, Neuroscience

Assistant or Associate Professor, Neuroscience

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Description:

The Department of Neurosciences, Case Western Reserve University School of Medicine invites applications for a tenure-track faculty position at the rank of Assistant or Associate Professor. We seek applicants who utilize innovative methodological approaches to investigate basic mechanisms of neural development, regeneration, or neural circuit function and how perturbation of these mechanisms contributes to neurological, neurodegenerative, and/or psychiatric diseases. The new investigator will have the opportunity to interact and collaborate with a diverse group of individuals in basic science and clinical departments within the School of Medicine, University Hospitals Cleveland Medical Center, Cleveland Clinic, Louis Stokes Cleveland VA Medical Center, and MetroHealth Medical Center. Case Western Reserve University has an outstanding infrastructure for biomedical research including recently renovated animal facilities and core facilities supporting state-of-the-art methodologies in cellular and whole animal imaging, behavioral analyses, and proteomics and genomics. Case Western Reserve University School of Medicine has committed significant resources for major expansion of neuroscience research.


Applicants for a position as Assistant Professor should have a Ph.D. and/or M.D. degree, 3 to 5 years postdoctoral experience, and a strong record of scholarly activity. Candidates for appointment as Associate Professor should have these credentials and be nationally recognized scholars with a strong, externally funded research program.


Applications should include a cover letter, curriculum vitae, statement of research interests, names of three references and be submitted electronically at apply.interfolio.com/49561. The Interfolio application site will open on April 20th and close on June 20th. For technical questions about your application, please contact Interfolio directly at 877-997-8807 or help@interfolio.com.


Link: http://apply.interfolio.com/49561
Employer: Case Western Reserve University
Location: Cleveland, OH
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: April 20th, 2018
Applications close: June 20th, 2018
Case Western Reserve UniversityCleveland, OHPhDNDGApr 20, 2018
Assistant or Associate Professor, Pathology

Assistant or Associate Professor, Pathology

(Click title to open job details in a new window.)
Description:

The Department of Pathology in the Rady Faculty of Health Sciences, University of Manitoba invites applications for a full-time tenured or tenure-track position at the Assistant or Associate Professor level, commencing on July 1, 2018, or on a date mutually agreed upon. The Department seeks an emerging scholar with a commitment to excellence in research and teaching. Outstanding candidates in any area of developmental neurobiology / developmental neuropathology will be preferred. A competitive start-up package will be provided. Salary and rank will be commensurate with experience and qualifications. The new recruit is expected to develop and maintain a rigorous and independently funded research program that will preferably complement or extend the department’s strengths in perinatal and developmental neuropathology. Other duties will include undergraduate teaching, graduate teaching and supervision, and service-related activities.


The successful candidate will have a Ph.D. and at least 2 years relevant post-doctoral research experience; a track record of high quality scholarly research leading to peer reviewed publications; will have, or demonstrate the potential to establish an independent, innovative, scholarly, externally fundable research program and will have demonstrated strength in or strong potential for teaching contributions. Experience with working with human tissue is particularly desirable. Preference will be given to candidates with demonstrated evidence of the ability to work in a collaborative environment.


Application materials, including letters of reference, will be handled in accordance with the Freedom of Information and Protection of Privacy Act (Manitoba). Applications will be accepted until May 15, 2018 or until the position has been filled.


Applications must include: a cover letter, a curriculum vitae, a summary of research interests, a three page research plan (covering the first year and 3-5 years), a description of teaching philosophy, and the names and contact information of three referees for letters of reference (in a single PDF file). Please ensure to specify position number 25772 in the application. Applications should be addressed to the chair of the search committee:


Dr. Gabor Fischer, Department Head

Department of Pathology

Rady Faculty of Health Sciences

University of Manitoba

401 Brodie Centre – 727 McDermot Avenue

Winnipeg, Manitoba R3E 3P5


Link: https://www.researchgate.net/job/908942_Assistant_Associate_Professor-Department_of_Pathology
Employer: University of Manitoba
Location: Winnipeg, Manitoba
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: April 19th, 2018
Applications close: May 15th, 2018
University of ManitobaWinnipeg, ManitobaPhDNDGApr 19, 2018
Director, Therapeutic Development

Director, Therapeutic Development

(Click title to open job details in a new window.)
Description:

We are currently seeking a new Director of Therapeutic Development to over see the Program of Excellence focused on Neurodegenerative Diseases.


Reporting to the Executive Director of the Orphan Disease Center (ODC) and supporting a Program of Excellence, your goal will be to provide international leadership in establishing research agenda in rare disease that are a high priority of the ODC. You will be developing strong partnerships with key stakeholders, including patient advocacy groups, partnering academic institutions and key opinion leaders in relevant diseases by organizing international scientific symposiums related to diseases of interest to the program of excellence, partnering with ODC staff to organize these events. You will have the primary responsibility for creating and executing a strategic plan, to establish clinical development for novel therapeutics. You will seek advisement from all relevant stakeholders, including patient advocacy groups, ODC leadership, and external advisors in initial development of this plan. In executing this plan, you will undoubtedly be required to have extensive interactions with biopharmaceutical industry partners, knowledgeable on the development of novel therapeutics and will require you to travel to biomedical conferences. You will establish working groups within each disease to address research and clinical practice gaps, and focus on filling those gaps to further the development of effective treatments.


You will be critical in the success of the program of excellence, providing careful oversight of the research conducted by grant recipients, assuring progress and progression of science towards a biopharmaceutical partnership. It will be essential that you have experience in biopharm to assure these critical links occur between the grant recipients and corporate partners.


Joining the ODC offers you with unique opportunity to contribute to revolutionizing the practice of medicine for these under-served patient groups.


Link: https://main.hercjobs.org/jobs/10953869/director-therapeutic-develpment-neurodegenerative
Employer: University of Pennsylvania School of Medicine
Location: Philadelphia, PA
Sector: Academia
Degree required:
Conditions: NDG
Job posted: April 18th, 2018
University of Pennsylvania School of MedicinePhiladelphia, PANDGApr 18, 2018
Postdoctoral Fellow, Gopal Lab

Postdoctoral Fellow, Gopal Lab

(Click title to open job details in a new window.)
Description:

Motivated PhD graduates seeking research training in the cell biology of neurodegenerative disease are invited to apply to postdoctoral research position(s) in the Department of Pathology at Yale University. Successful candidates will utilize live cell and super-resolution imaging techniques, mass spectroscopy/CyTOF and biochemistry in primary neurons and mouse models, iPSC-derived neurons, and/or patient tissue samples to define the molecular mechanisms driving assembly, transport, and cellular functions of neuronal ribonucleoprotein (RNP) complexes under physiologic conditions and in neurodegenerative disease.


Emphasis will be placed on defining molecular mechanisms relevant to the pathophysiology of age-related inherited and sporadic neurodegenerative diseases, including Alzheimer’s disease and related dementias, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS), with a long-term goal of guiding the development of novel therapies. Recent work has used live cell and super-resolution imaging techniques to study the biophysical properties of neuronal ribonucleoprotein granules and has shown that ALS-linked mutations fundamentally perturb the dynamic properties and transport of neuronal RNP complexes.


Successful candidates will be guided to develop independent research careers under the mentorship of Dr. Gopal. Strong written and verbal communication skills, as well as a track record of publications in peer-reviewed journals, are required.


Candidates should have prior expertise in cellular and molecular neurobiology, genetics, and the design and characterization of CRISPR and/or transgenic mouse models. Prior experience with iPSC-derived neurons, CRISPR gene-editing techniques, RNA imaging, quantitative analysis of imaging data, and/or characterizing mouse models of neurodegenerative or neurodevelopmental disorders is highly desirable.


Interested candidates should forward a cover letter, curriculum vitae, and a 1-2 page description of their research interests, together with the names and contact information of three references via email to: pallavi.gopal@yale.edu


Link: https://www.linkedin.com/jobs/view/625914190/
Employer: Yale University School of Medicine
Location: New Haven, CT
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: April 17th, 2018
Yale University School of MedicineNew Haven, CTPhDALSApr 17, 2018
Postdoctoral Fellow, Sareen Lab

Postdoctoral Fellow, Sareen Lab

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Description:

Dr. Dhruv Sareen’s independent research laboratory at the Cedars-Sinai Medical Center, Regenerative Medicine Institute focuses on using human iPSC technology to understand the molecular mechanisms underlying neurodevelopmental/degenerative diseases and how obesity is linked to the brain. His laboratory is particularly interested ‘disease-in-a-dish’ modeling for neuromuscular, neurodegenrative and motor neuron diseases including, amyotrophic lateral sclerosis (ALS). They are particularly interested in C9orF72 and other genetic forms of ALS and what are the common elements with sporadic forms of ALS. Using the iPSC platform his lab has developed novel methods for drug screening on patient motoneurons and dissecting mechanisms for motoneuron degeneration. In the context of stem cell modeling of neurodevelopmental (SMA) and neurodegenerative diseases (ALS) Dr. Sareen’s group is particularly interested in the mechanistic insights how specific neural cell types degenerate during the disease processes. They are using OMICS (proteome, transciptome, metabolome) and imaging methodologies to gain mechanistic insights into the mitochondrial and endorplasmic reticulum stress involvement. In addition, by understanding how the cells of the nervous system develop and differentiate we will be able to develop better and safer cells for transplantation and regenerative therapies. Dr. Sareen’s group has extensive experience in pluripotent and neural stem cell research. He has developed and directed a well-renowned human iPS cell core. He has published high-profile manuscripts on human iPSC-based disease modeling in SMA and ALS.


Dr. Sareen’s laboratory is searching for a highly-capable Post-doctoral Researcher to join his research group to investigate disease mechanisms in neurodegenerative diseases, especially motor neuron disorders. The incumbent should have experience in in neurobiology, biochemistry, molecular biology and stem cells, including analyzing their genetic and biochemical profiles by OMICS technologies. Bioinformatics (programming in R) knowledge is a plus. By using human iPS cell technology and differentiating into different brain cells as well as other tissues of the body we will investigate brain-linked disease mechanisms to develop assays in patient-derived enural cell types and screen for novel therapeutics. Working independently but in close cooperation and in consultation with the PI and other Research Scientists at RMI, the Post-doctoral Researcher will perform routine and complex laboratory procedures throughout. The Post-doctoral Researcher will be expected to assist the PI in preparation of multiple grant proposals and submission of such proposals. They will also prepare full manuscripts for publication as primary first and co-authors. The researcher will be expected to assist the PI in maintaining institutional IRB/SCRO protocols as well as develop new animal and IACUC protocols. The incumbent will develop, adapt, and implement new research techniques and protocols and will analyze and interpret data. They will participate in presentations as author or co-author on scientific meeting abstracts.


Under the direction of Dr. Sareen (PI) the incumbent will help us achieve our research goals by performing the principal duty of using pluripotent and neural stem cell culture techniques to generate neuronal and other tissue differentiation protocols, characterization of the differentiated cells (control vs disease) using techniques such as gene and protein expression, physiological, and phenotypic assessments. The candidate will also be expected to develop and perform differentiation protocols to direct pluripotent stem cells to endoderm, ectoderm and mesoderm lineages. The successful candidate will be responsible for all cell maintenance, expansion and genetic modification using viral vectors or other gene-editing methods. Therefore, experience in stem cell and neurobiology, knowledge of pluripotent/neural cell markers combined with a proven record in stem cell culture techniques is essential. Experience with bioinformatics analysis of RNA-seq and mass spec proteomics data are important.


Prior experience in novel genome-editing technologies (CRISPR/Cas9) using pluripotent stem cells is a great asset. Prior experience in high-content compound screening/imaging techniques, handling of the Molecular Devices Image Express Micro system, and a Mass Spectrometer with data analysis are preferred traits. Proficiency in computer algorithm development for automating image-based analysis is also a desirable trait.


Link: https://main.hercjobs.org/jobs/10948963/postdoctoral-scientist-ipsc-on-neurodegenerative-disease
Employer: Cedars Sinai
Location: Los Angeles, CA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: April 17th, 2018
Cedars SinaiLos Angeles, CAPhDALSApr 17, 2018
Professor, Structural Biology (W3)

Professor, Structural Biology (W3)

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Description:

The Institute of Neuropathology, University Medical Center Göttingen (UMG) invites applications for a professorship (W3), structural cell biology commencing as soon as possible.


The applicant should be a highly qualified, internationally visible scientist with his or her own scientific profile as well as comprehensive knowledge of and longtime experience in the application of cryo electron microscopy and cryo electron tomography for the structural biology of excitable cells. Profound knowledge of computer-based image analysis and mathematical physical model development must be included in the successful applicant’s profile. Experience in correlating investigations using light microscopy and electron microsopy is also advantageous.


Please submit your application until 13rd May using the following link: http://www.med.uni-goettingen.de/de/content/ueberuns/berufungen_onlinebewerbung.html


Please send any questions you may have to Berufungen@med.uni-goettingen.de, we will try to answer them.


Link: http://www.med.uni-goettingen.de/de/content/ueberuns/berufungen_onlinebewerbung.html
Employer: University Medical Center Göttingen
Location: Göttingen, Germany
Sector: Academia
Degree required:
Conditions: NDG
Job posted: April 17th, 2018
Applications close: May 13th, 2018
University Medical Center GöttingenGöttingen, GermanyNDGApr 17, 2018
Research Assistant

Research Assistant

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Description:

We are seeking a research assistant to produce proteins related to the ALS (Motor Neuron disease), as part of an international project to generate high-quality antibodies for therapeutic research.


You will have a degree in biology/biochemistry and proven experience in cloning, expressing and purifying proteins from bacterial and eukaryotic cells. You will be required to adapt or develop procedures for expressing and purifying the target proteins to a high standard of yield and purity.


You will be able to work as part of a multidisciplinary team and be well-organised in planning and documenting experiments.


The post is full-time and available on a fixed-term contract until 31 December 2020 in the first instance.


You will be required to upload a CV and supporting statement which explains how you meet the selection criteria for the post.


Only applications received before 12.00 noon on 14 May 2018 will be considered.


Link: http://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=134505
Employer: University of Oxford
Location: Oxford, England
Sector: Academia
Degree required:
Conditions: ALS
Job posted: April 17th, 2018
Applications close: May 14th, 2018
University of OxfordOxford, EnglandALSApr 17, 2018
Postdoctoral Fellow

Postdoctoral Fellow

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Description:

The PostDoc Fellow will participate in the discovery and evaluation of candidate targets affecting motor unit function and subsequent sensory motor performance following stroke, SCI, and/or ALS. The PostDoc Fellow may also be expected to study the effects of various clinical interventions in order to aid the design of rehabilitation strategies targeting specific motor unit properties.


*Design, execution and interpretation of experiments for the discovery of critical information in motor unit biology as it relates to the condition of-, or recovery from stroke, SCI and/or ALS.

*Independent leadership of research projects in a team environment

*Participates in regular development meetings with supervising team members.

*Keeps informed of developments in field to maintain and enhance professional expertise; offers suggestions regarding continuing development of program.

*Participates in research activities.


Link: https://ricc-hr.silkroad.com/epostings/index.cfm?fuseaction=app.jobinfo&jobid=179121&company_id=16087&version=1&source=ONLINE&jobOwner=994841&aid=1
Employer: Shirley Ryan Ability Lab
Location: Chicago, IL
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: April 15th, 2018
Shirley Ryan Ability LabChicago, ILPhDALSApr 15, 2018
Assistant or Associate Professor

Assistant or Associate Professor

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Description:

The Department of Developmental Biology (www.devbio.pitt.edu) at the University of Pittsburgh School of Medicine is recruiting an outstanding tenure-track or tenured faculty at the Assistant to Associate Professor level. Candidates should have an innovative research program in the area of developmental neurobiology. The use of mouse, zebrafish, and/or stem cell culture or organoid models (iPSC or ES) with strong translational relevance to neurodevelopmental disorders are particularly encouraged to apply. Successful candidates must hold the PhD, MD, or MD/PhD degrees, and have a strong research program with an outstanding publication record. The successful candidate will be housed in new space at the Rangos Research Center of the Children’s Hospital of Pittsburgh with state of the art core facilities, includingFACS facility, vivarium, rodent behavioral core, small animal imaging facility, and others.


Link: https://main.hercjobs.org/jobs/10937111/associate-professor
Employer: University of PIttsburgh
Location: Pittsburgh, PA
Sector: Academia
Degree required: PhD, MD, or MD/PhD
Conditions: NDG
Job posted: April 13th, 2018
University of PIttsburghPittsburgh, PAPhD, MD, or MD/PhDNDGApr 13, 2018
Research Assistant

Research Assistant

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Description:

Applications are invited for the post of Research Assistant working on an exciting project which aims to improve the way in which the NHS delivers respiratory therapies, such as non-invasive ventilation (NIV), to patients with motor neurone disease (MND). You will work on Work Packages 2, 3 and 4 of this project. Work Package two involves carrying out a survey to explore current clinical practices and standards relating to the use of NIV in MND in the UK and in similar services to the NHS within Europe. Work Package 3 involves carrying out stakeholder consultations to explore and contextualise the research findings from previous Work Packages and to gain input about how best to translate them into clinical practice. Work Package 4 focuses on creating and testing a practical information toolkit to support the practice of healthcare professionals involved in the respiratory management of MND patients.


You will work to closely with clinicians and researchers at University of Sheffield’s Department of Neuroscience Sheffield Institute for Translational Neurosciences, the School of Health and Related Research, the Psychology department and IT specialists. SITraN is in an internationally recognised multidisciplinary group of scientists and clinicians with expertise in translating research into clinical practice in neurological diseases and is a core member of the prestigious NIHR Sheffield Biomedical Research Centre.


The salary is Grade 6, £25,728 – £29,799 per annum. Potential to progress to £32,548 per annum. To apply for this position, click here.


Link: https://jobs.shef.ac.uk/sap/bc/webdynpro/sap/hrrcf_a_posting_apply?PARAM=cG9zdF9pbnN0X2d1aWQ9MkQ5RkQ5OUM1NDI1MUVEODhGQUQzQTVERjE0NTlEOEUmY2FuZF90eXBlPUVYVA%3d%3d&sap-client=400&sap-language=EN&sap-accessibility=X&sap-ep-themeroot=%2fSAP%2fPUBLIC%2fBC%2fUR%2fuos#
Employer: University of Sheffield
Location: Sheffield, England
Sector: Academia
Degree required:
Conditions: ALS
Job posted: April 13th, 2018
Applications close: April 25th, 2018
University of SheffieldSheffield, EnglandALSApr 13, 2018
Postdoctoral Fellow, Sun Lab

Postdoctoral Fellow, Sun Lab

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Description:

Postdoctoral opportunities are available in Dr. Shuying Sun’s laboratory at Johns Hopkins University School of Medicine. The lab will explore the fascinating frontiers of RNA metabolism dysfunction and RNA-targeting therapy in neurodegenerative diseases by combining molecular and cellular approaches, genome editing, proteomic, genomic and screening platforms.


The nervous system has extremely complex RNA processing regulation and dysfunction of RNA metabolism has emerged to play crucial roles in multiple neurological diseases. Mutations and pathologies of several RNA-binding proteins are found to be associated with neurodegeneration in both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). An alternative RNA-mediated toxicity arises from microsatellite repeat instability in the human genome. The expanded repeat-containing RNAs could potentially induce neuron toxicity by disrupting protein and RNA homeostasis through various mechanisms.


The Sun lab is interested in deciphering the molecular mechanisms of disease pathogenesis and seeks to translate the mechanistic findings to therapeutic target development to advance treatment options against neurodegenerative diseases. We are looking for highly motivated postdoc fellows with solid PhD training in biochemistry, molecular and cellular biology. Experiences with RNA biology, neuroscience or bioinformatics are preferred but not limited to. You will join a strong and highly interactive science community at Johns Hopkins.


Interested candidates should provide a cover letter (with statement of research interest and career goals), CV and the contact information for three references to Dr. Shuying Sun at shuying.sun@jhmi.edu. Please visit our lab website at http://labs.pathology.jhu.edu/sun/ for additional information.


Link: https://www.nature.com/naturejobs/science/jobs/641473-postdoctoral-positions-on-rna-biology-and-neurodegenerative-disease
Employer: Johns Hopkins University School of Medicine
Location: Baltimore, MD
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: April 10th, 2018
Johns Hopkins University School of MedicineBaltimore, MDPhDALS, FTDApr 10, 2018
Research Associate

Research Associate

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Description:

The Center for Genomics of Neurodegenerative Disease at the New York Genome Center is looking for a well-organized, methodical, and highly motivated Research Associate. This is an exciting opportunity to become part of a dynamic group that is investigating the interactions between motor neurons and glial cells in ALS pathology using hiPSC cell-based models combined with next generation sequencing and CRISPR technology. Our particular focus is to examine the transcriptional, translational, and functional impact of causative ALS mutations in a cell type specific manner. The individual will interface with the Director and key scientific staff to assume responsibility for hiPSC culture, differentiation, functional assays, and RNA harvesting for NGS. The Research Associate will be part of an interdisciplinary team working in a fast-paced environment.


Responsibilities Include, But Are Not Limited To

*Conduct, design, and troubleshoot experiments, both independently and in collaboration with colleagues;

*CRISPR-based genome editing and transcriptional perturbations of causative ALS genes;

*Differentiation of hiPSCs into motor neurons and glial cells;

*Consult with scientific literature and other scientists as needed to better understand scientific experiments and problems, and propose solutions to emerging problems;

*Perform routine biochemical and molecular biology techniques (PCR, nucleic acid purification, qPCR, ELISA, Western blotting, etc.);

*Record and communicate findings accurately and professionally.


Link: https://nygenome-openhire.silkroad.com/epostings/index.cfm?fuseaction=app.dspjob&jobid=265&company_id=17105&version=1&jobBoardId=3347
Employer: New York Genome Center
Location: New York, NY
Sector: Academia
Degree required: BS or MS
Conditions: ALS
Job posted: April 9th, 2018
New York Genome CenterNew York, NYBS or MSALSApr 09, 2018
Assistant Professor of Neurology

Assistant Professor of Neurology

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Description:

The Center of Image Acquisition (CIA) at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute seeks a qualified applicant for an Assistant Professor (tenure track) position in the USC Department of Neurology. The CIA serves as central resource for the development and application of advanced imaging for all neuroimaging research at the Keck School of Medicine of USC. The CIA will interact and collaborate with many departments at the Health Sciences Campus and the University Park Campus conducting research in methodology and its application in the study of normal, neurological and psychiatric cohorts. The ideal candidate should have a Ph.D. in Biophysics, Biomedical Engineering, or a related field, and have 2-3 years of postdoctoral training in the field of MRI physics and its applications in neuroscience. The candidate is expected to develop innovative MRI techniques, in particular noninvasive blood flow and perfusion imaging. The main duties of this position include the development of an independent and/or collaborative research program and participation in multidisciplinary research applying novel MRI imaging techniques for assessing and diagnosing neurovascular and neurodegenerative diseases. Experience on pulse sequence programming, particularly on Siemens platform is highly desirable.


Link: https://jobs.sciencecareers.org/job/477691/assistant-professor-of-neurology-tenure-track-/
Employer: University of Southern California
Location: Los Angeles, CA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: April 5th, 2018
University of Southern CaliforniaLos Angeles, CAPhDNDGApr 05, 2018
Assistant Professor, Neurology

Assistant Professor, Neurology

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Description:

The USC Stevens Neuroimaging and Informatics Institute (INI) seeks highly-qualified applicants for the position of Assistant Professor (tenure-track). The successful applicant will have a minimum 5+ years experience (post doctoral degree) in imaging in aging and neurodegenerative diseases. A particular emphasis on functional and structural connectivity in Alzheimer’s disease is desired. The candidate should have specific interest in mechanistic processes of aging include neuroinflammation, and/or genetics. A strong foundation in understanding the role of imaging, genetics, and clinical phenotypes in characterizing age- and disease-related phenomena is desired. The candidate should have a PhD in Neuroscience, Psychology, or other related disciplines; a strong foundation in neuroimaging and 5+ years post-PhD research experience with a successful publication record and teaching experience is required. The applicant must demonstrate an ability to work with a highly collaborative and multidisciplinary team. Further, the applicant must have demonstrated a strong track record of obtaining independent funding to support a research program.


To apply, include a cover letter, CV, salary history and list of references. Include in your cover letter where you saw this posting or how you learned of this opening.


Link: https://jobs.sciencecareers.org/job/477692/assistant-professor-of-neurology-tenure-track-/
Employer: University of Southern California
Location: Los Angeles, CA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: April 5th, 2018
University of Southern CaliforniaLos Angeles, CAPhDNDGApr 05, 2018
Postdoctoral Fellow, Deleidi Lab

Postdoctoral Fellow, Deleidi Lab

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Description:

A position for a talented and highly motivated Postdoctoral Researcher is available within the scientific team “Mitochondria and Inflammation in Neurodegeneration” led by Michela Deleidi in Tübingen. The research focus of our group is on the molecular mechanisms of neurodegeneration, with a special emphasis on the role of inflammation in neurodegenerative diseases. Neuroinflammatory genes have been associated with several neurodegenerative diseases, including Parkinson’s disease. Our aim is to understand, at the molecular level, how immune responses within or outside the brain contribute to neurodegeneration. Our final goal is to translate fundamental discoveries to better preventive and therapeutic approaches for neurodegenerative diseases. Please see our website for more information about our research: https://www.dzne.de/en/research/research-areas/fundamental-research/research-groups/deleidi/research-areasfocus/.


The successful candidate will conduct a research project aimed at further elucidating the link between metabolic and energetic defects and immune homeostasis in Parkinson’s disease. The project will involve close collaborations with international partners. For this project, a combination of in-vitro models (human cell lines including induced pluripotent stem cells) and in-vivo models (mouse models) will be used as well as a variety of approaches including use of human induced pluripotent stem cells (2D, 3D and brain organoids), CRISPR-Cas9 genome editing, flow cytometry, microscopy, RNA-seq and metabolomics, and use of in-vivo models (with external collaborators). You will conduct your own research project, collaborating with PhD and Postdoctoral Researchers as well as international partners. The goal is to publish our work in outstanding scientific journals.


Link: https://www.nature.com/naturejobs/science/jobs/641215-postdoctoral-researcher-f-m
Employer: German Center for Neurodegenerative Diseases
Location: Tübingen, Germany
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: April 5th, 2018
German Center for Neurodegenerative DiseasesTübingen, GermanyPhDNDGApr 05, 2018
Postdoctoral Fellow, Dupuis Lab

Postdoctoral Fellow, Dupuis Lab

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Description:

A 3-year post-doctoral position is available in Inserm U1118, Strasbourg, France under the supervision of Dr Luc DUPUIS.


The successful candidate will investigate the relationships between TAU, FUS and TDP-43 in the development of amyotrophic lateral sclerosis and fronto-temporal dementia, two related neurodegenerative diseases currently untractable. This will be done by combining mouse genetics and behaviour with molecular biology techniques based on next generation sequencing and pathological studies in patient tissues.


An experience in NGS techniques such as RNAseq and/or CLIPseq will be highly appreciated.


The position is secured for 3 years, and funded by the ANR.


Applications including a detailed CV and contact of at leat two previous supervisors, should be sent to Dr Luc Dupuis (ldupuis@unistra.fr).


Recent publications from the laboratory:


Vercruysse P, et al. Brain. 2016, Apr;139(Pt 4):1106-22.

El Oussini H, et al. Acta Neuropathol. 2016, 131(3):465-80

Scekic-Zahirovic J.,et al. EMBO J., 2016, 35(10):1077-97. doi: 10.15252/embj.201592559.

Dentel C, et al. . Brain. 2013 Feb;136(Pt 2):483-93.

Kabashi E, et al. Hum Mol Genet. 2013 Jun 15;22(12):2350-60.

Dupuis L, et al. Lancet Neurol. 2011 Jan;10(1):75-82.


Employer: Inserm U1118
Location: Strasbourg, France
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: April 4th, 2018
Inserm U1118Strasbourg, FrancePhDALS, FTDApr 04, 2018
Research Associate II, Svendsen Lab

Research Associate II, Svendsen Lab

(Click title to open job details in a new window.)
Description:

The Svendsen Laboratory at Cedars-Sinai Medical Center, Regenerative Medicine Institute is looking for personnel to join our dynamic group. The ideal incumbent should have experience in managing and analysis of large datasets using programming languages such as Python and R, and an interest in working hands on with stem cells and organ-on-chip technology with a focus on research in neurodegenerative diseases (Brain-on-Chip). Ideal candidate will also have experience in machine learning approaches for use in automation of laboratory equipment and analysis of complex bioinformatic datasets. Working with the P1 and scientists, the Research Associate II (RA11) performs a variety of routine experimental protocols and procedures to support the objectives of one or more laboratory research projects in a specific area of research, including the Brain-on-Chip program. RAII is responsible for the generation and curation of acquired data, implementation of analysis programs, and generation of scripts to assists in laboratory activities and research aims. RAH is responsible for general laboratory activities including maintenance of reagents, ordering and stocking of supplies. RA11 keeps accurate and detailed records of experiments and results. RAH assists in the operation of specialized equipment and machinery, including the culture of human stem cell derived tissues. Observes safety standards and procedures. This position may include supervisory responsibilities. Daily Duties will include the following: – Performs a variety of routine laboratory tasks and procedures. – Works with laboratory staff to develop and implement analysis frameworks for use in biomarker and therapeutic target discovery – Keeps accurate and detailed project records of experiments and results. – Maintains lab equipment and related records. – Transports, processes and logs samples. – Maintains computer database with relevant information – implements scripts for the analysis of complex imaging and multi-omic analysis datasets. – Performs lab maintenance duties, including glassware cleaning and sterilization, – Maintains stocks of general lab materials, and places orders for lab equipment and supplies. – Assists new students and fellows at the laboratory. – Assists in the operation of specialized equipment and machinery. – Observes and complies with safety standards arid procedures. – Histology and Microscopy – Sectioning of tissue specimens – Staining of tissue specimens to include special stains and INC. Additional Information: Scheduling flexibility including evening, weekend and holiday rotation commitment is required. Travel may be required.


Link: https://main.hercjobs.org/jobs/10908722/research-associate-ii-stem-cells
Employer: Cedars-Sinai
Location: Los Angeles, CA
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: April 4th, 2018
Cedars-SinaiLos Angeles, CABA or BSALSApr 04, 2018
Research Associate, McDermott Lab

Research Associate, McDermott Lab

(Click title to open job details in a new window.)
Description:

We are seeking an outstanding early-career researcher with the potential to become a leader in the field of mixed-methods health services research. You will join the research group of Professor Christopher McDermott at the Sheffield Institute for Translational Neuroscience (SITraN) to work on clinical research projects focusing on the supportive and symptomatic management of patients with motor neurone disease (MND) and other neurodegenerative disorders.


This post provides an excellent opportunity to undertake high quality research within a stimulating multi-disciplinary context. You will work directly with a team of clinicians and researchers on HighCALS, a National Institute for Health (NIHR) funded research programme, with the aim to develop and evaluate a complex intervention to achieve a high calorie diet for people with Amyotrophic Lateral Sclerosis (ALS). HighCALS is a collaboration of co-investigators from the Sheffield Institute for Translational Neuroscience (SITraN), the School of Health and Related Research (ScHARR) and the Department of Psychology at the University of Sheffield; and the School of Food Science and Nutrition at the University of Leeds.


You will have a Masters or PhD in a relevant discipline or equivalent experience.


This post is full time, fixed term for 2 years. The salary is Grade 7,

£30,688 – £38,883 per annum.  Potential to progress to £42,418 per annum.


Link: https://jobs.shef.ac.uk/sap/bc/webdynpro/sap/hrrcf_a_posting_apply?PARAM=cG9zdF9pbnN0X2d1aWQ9MkQ5RkQ5OUM1NDI1MUVFODhDQ0QzOTQ3RTQ3MzE3NEYmY2FuZF90eXBlPUVYVA%3d%3d&sap-client=400&sap-language=EN&sap-accessibility=X&sap-ep-themeroot=%2fSAP%2fPUBLIC%2fBC%2fUR%2fuos#
Employer: University of Sheffield
Location: Sheffield, England
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: April 4th, 2018
Applications close: May 2nd, 2018
University of SheffieldSheffield, EnglandPhDALSApr 04, 2018
Chair, Department of Translational Neurosciences

Chair, Department of Translational Neurosciences

(Click title to open job details in a new window.)
Description:

The University of Arizona College of Medicine – Phoenix is seeking an inaugural Chair for its new Department of Translational Neurosciences (TNS). TNS will be a novel medical school department, one that actively bridges basic science and clinical medicine through innovative collaborative research programs. The Chair will have the opportunity to create the overarching vision and, through strategic leadership, to build a center of translational neuroscience excellence. The Department Chair will have resources to recruit TNS faculty who will enhance our University of Arizona Health Sciences (UAHS) scientific community. We seek a visionary leader with expertise in molecular, cellular, or genetic approaches to neuroscience whose research is motivated by the challenges of nervous system disorders and directed toward advancing clinical care and improving human health in the foreseeable future.


Of particular interest for the Chair of TNS position are applicants with any of the following:


*Research portfolio focused on molecular, cellular, and/or genetic approaches to neuroscience. Examples of foci include: Neurodevelopmental disorders, Neuropsychiatric disorders, Disorders of the aging brain

*Expertise in use of cutting-edge technologies, including, but not exclusive to, patient-specific iPSC lines, CRISPR-Cas9, and in vivo brain imaging.

*Development and use of new animal models for disorders of the nervous system.

*Expertise in drug discovery or device development, including advancing to clinical trials.

*Knowledge of intellectual property issues in biomedical research (e.g., patent applications, working with industry partners).

*History of productive collaborations with both physicians and basic scientists.

For physician candidates, clinically active in specialty.


Link: https://uacareers.com/postings/26190
Employer: University of Arizona College of Medicine
Location: Phoenix, AZ
Sector: Academia
Degree required: PhD and/or MD
Conditions: NDG
Job posted: April 2nd, 2018
University of Arizona College of MedicinePhoenix, AZPhD and/or MDNDGApr 02, 2018
Postdoctoral Fellow, Durham Lab

Postdoctoral Fellow, Durham Lab

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Description:

A postdoctoral position in ALS research is available in the laboratory of Dr. Heather Durham in the Rare Neurological Diseases Group at the Montreal Neurological Institute, McGill University, Montreal QC Canada. The project involves investigating the role of chromatin remodeling as a convergent mechanism in ALS and in neuronal stress responses (see https://www.ncbi.nlm.nih.gov/pubmed/28973294). The work would include investigation of epigenetic mechanisms in primary culture models, mouse models and post-mortem tissue as well as participation in a drug study in mouse and tissue culture models of ALS. This multidisciplinary project is funded by MDA and by an ALS Canada-Brain Canada Hudson Translational Team Grant involving collaborators with complementary expertise at other Canadian universities.


Applicants are expected to have a PhD in a relevant biomedical field; to be able to work independently as well as a team member, and to bring a passionate interest in working together to understand the pathogenesis of ALS and to find effective treatment. Expertise in epigenetics, stress responses, molecular biology, biochemical assays, mouse models and tissue processing/histochemical techniques are examples of useful experience to complement our team.


To apply for this position, contact Dr Heather Durham.


The Montreal Neurological Institute and Hospital – The Neuro (http://www.mcgill.ca/neuro/), is a world-leading destination for brain research and advanced patient care. Since its founding in 1934 by renowned neurosurgeon Dr. Wilder Penfield, The Neuro has grown to be the largest specialized neuroscience research and clinical centre in Canada, and one of the largest in the world. The seamless integration of research, patient care, and training. The Neuro is home to one of the leading ALS clinics and clinical research units, providing interaction between ALS scientists, clinicians and patients.


 


Employer: McGill University
Location: Montreal, Canada
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: March 30th, 2018
McGill UniversityMontreal, CanadaPhDALSMar 30, 2018
Group Leader, Big Data Neuroscience

Group Leader, Big Data Neuroscience

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Description:

Can you develop a productive and innovative research program and establish an independent research group through a combination of core funding and extramural funding? Can you complement the research program of the NIN by working in close collaboration with other research groups at the institute? And do you have a clear vision on how to approach the current challenges in one of the three neuroscience research fields described below? Then this job may be for you.


There is an increasing global collaboration to collect, pool and distribute huge datasets on human genetics, gene expression and brain imaging in order to understand the neurobiological underpinnings of a wide variety of complex traits and phenotypes in health and disease. To bridge these opportunities with current research topics and facilities like the Brain Bank and 7T MRI at the NIN, we are seeking an outstanding scientist who is leading in the innovative use of datasets like the UKBiobank, 23andMe and ENIGMA. The ideal candidate has mathematical, computational, statistical, neurobiological and cognitive-behavioral expertise, as well as technological skills for cluster computing.


Applications should be submitted via the online application form, before 30 April 2018:



  • A cover letter and a statement summarizing your research interests and motivation (max 1 page)

  • A curriculum vitae including a complete list of publications and a list of your five best papers

  • Your previous research accomplishments and your future research goals (max 2 pages)

  • The name and email addresses of up to three referees


The pre-selection will be done by a gender-balanced panel of peers from the institute.


For further information you can look at our website: nin.nl or contact Pieter Roelfsema p.roelfsema@nin.knaw.nl, General Director, Ronald van der Neut r.van.der.neut@nin.knaw.nl, Managing director, or Dorien Bisselink d.bisselink@nin.knaw.nl, head human resources department.


Link: https://www.academictransfer.com/employer/KNAW/vacancy/46229/lang/en/
Employer: Netherlands Institute for Neuroscience
Location: Amsterdam, Netherlands
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: March 28th, 2018
Applications close: April 29th, 2018
Netherlands Institute for NeuroscienceAmsterdam, NetherlandsPhDNDGMar 28, 2018
Postdoctoral Fellow, Van Damme Lab

Postdoctoral Fellow, Van Damme Lab

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Description:

The Laboratory of Neurobiology is part of the research group Experimental Neurology (Neuroscience Department) at KU Leuven. The group has a close collaboration with the Neurology Department of the University Hospitals Leuven with about 50 researchers in different domains.


In addition, the laboratory is one of the research groups of the VIB Center for Brain & Disease Research (CBD) at KU Leuven/ Campus Gasthuisberg focusing on Neuroscience. There are 17 research groups within the CBD with a total employment of 300 researchers (38 different nationalities).


The Laboratory focusses on clinical and fundamental research into the prevention, heredity, the pathogenesis and treatment of neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Charcot-Marie-Tooth Disease (CMT) and stroke.


We are looking for a highly motivated doctoral researcher with interest in neurodegeneration and experience in progranulin biology and/or iPSC technology. Motivated candidates with a strong commitment to basic research are invited to apply.


The research project, under supervision of principal investigator Philip Van Damme, will focus on the neurodegenerative disorders ALS and FTD and will involve in vitro techniques, validation of neuroprotective compounds, iPSCs and small animal models.


Applications should be submitted through the VIB website. Please complete the online application procedure and include a CV, a list of publications if applicable, a summary of past research and the contact information of 2 to 3 referees. The best-ranked candidates will be invited for an interview.


For additional information concerning this job offer, please contact Lien Houbrechts.


Link: https://www.nature.com/naturejobs/science/jobs/640803-phd-position-on-ipsc-models-in-neurodegeneration-als-and-frontotemporal-dementia
Employer: VIB
Location: Leuven, Belgium
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: March 27th, 2018
Applications close: May 27th, 2018
VIBLeuven, BelgiumPhDALS, FTDMar 27, 2018
Neuropathologist, Physician Scientist, Neurodegenerative Disease

Neuropathologist, Physician Scientist, Neurodegenerative Disease

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Description:

The Department of Pathology at Northwestern University Feinberg School of Medicine seeks a full-time Assistant Professor, Associate Professor or Professor on the tenure track. Qualified candidates will be physician-scientists MD or MD, PhD, and be Board-certified in Neuropathology. They are expected to develop a federally funded, independent research program in the area of neurodegeneration and engage in collaborations with other researchers who study neurodegenerative diseases throughout Northwestern University.


Service responsibilities include participation in diagnostic neuropathology, which could include surgical, autopsy or neurodegenerative neuropathology, depending on the applicant’s career goals. There will be ample opportunities for mentoring and teaching graduate students, medical students and resident/fellows, as well as for service on department, school or university committees. Qualified candidates will become a leader of the Neuropathology Core of the federally funded Cognitive Neurology and Alzheimer’s Disease Center.


The environment for hypothesis driven basic research, and for translational and collaborative research at Northwestern University and the Northwestern Memorial Hospital is outstanding. Interested applicants should submit a letter of interest, curriculum vitae, and names of three to five references via Northwestern University’s Faculty Recruiting Website.


Daniel J. Brat MD, PhD

Magerstadt Professor and Chairman

Department of Pathology

Northwestern University

Feinberg School of Medicine

303 East Chicago Avenue, Suite 3-140

Chicago, Illinois 60611


Link: https://jobs.sciencecareers.org/job/477324/neurodegenerative-neuropathologist-physician-scientist/
Employer: Northwestern University
Location: Chicago, IL
Sector: Academia
Degree required: MD or MD/PhD, and Board-certified in Neuropathology
Conditions: NDG
Job posted: March 26th, 2018
Northwestern UniversityChicago, ILMD or MD/PhD, and Board-certified in NeuropathologyNDGMar 26, 2018
Assistant, Associate or Full Professor, Molecular Pharmacology & Physiology

Assistant, Associate or Full Professor, Molecular Pharmacology & Physiology

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Description:

The Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine invites applications for tenure-track faculty positions at the Assistant/Associate/Full Professor levels. A doctoral degree in medical or biomedical sciences is required. Applicants must demonstrate a strong record of academic accomplishments with NIH-supported research programs. Expertise in neuroscience, cardiovascular, splanchnic organ system, metabolism and inflammation/immunology research areas is preferred, with an emphasis on the study of molecular, cellular and systemic mechanisms. Applicants must also demonstrate a history of medical school teaching excellence and are expected to have outstanding verbal communication skills.


Candidates should send their curriculum vitae that include previous and current research funding, teaching experience, a statement of research plans, and the names/contact information of three references in a single PDF to: Victoria Mothershed at vmothershed@health.usf.edu.


Link: https://jobs.sciencecareers.org/job/477224/assistant-associate-full-professor/
Employer: University of South Florida
Location: Tampa, FL
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: March 22nd, 2018
University of South FloridaTampa, FLPhDNDGMar 22, 2018
Postdoctoral Fellow, Mueller Lab

Postdoctoral Fellow, Mueller Lab

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Description:

We seek a talented and motivated postdoc to join the laboratory of Dr Christian Mueller in the Horae Gene Therapy Center at the University of Massachusetts Medical School. Our dynamic and collaborative research environment at UMMS includes world renowned clinicians and scientists. Additionally, our location close to Boston supports many collaborations with academic and industrial research groups.


Open positions include:  CNS Lead. Responsible for advancing the lab’s preclinical programs for CNS diseases. Lead indications are SOD1, C9orf72-linked amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). Projects will include early stage research on genome editing for ALS, an IND-enabling study in non-human primates for a gene therapy candidate for ALS, and an IND-enabling study in non-human primates for a gene therapy candidate for HD.


Required Qualifications:

Applicants should have a PhD in biomedical sciences with a strong background in molecular biology and biochemistry, as well a track record in the field of ALS/CNS disorders (CNS Lead role) or liver diseases (Liver Lead role). Hands-on experience with relevant mouse models as well as excellent knowledge of CRISPR-based genome editing are required. Ability to work independently in a fast-paced research environment and multitask, be highly organized and adaptable are required. Strong writing, verbal and interpersonal skills are required.


Required skills:

• PhD degree in biomedical sciences

• track record in ALS/CNS disorders or liver diseases with at least two first author publications

• hands-on experience with genetic mouse models (CNS or liver)

• excellent knowledge of CRISPR-based gene editing

• excellent communication skills both oral and written are essential

Preferred skills

• hands-on experience with CRISPR-based gene editing

• experience in next generation sequencing and bioinformatics

• experience in tissue culture, cytokine multiplex assays and ELISA

Additional Information:

Our lab is multicultural and supports personal development and work-life balance. Attractive salary and benefits available based upon relative working experience.


For more information on the Mueller Lab for Gene Therapy we invite you to visit our website: www.umassmed.edu/muellerlab

Interested candidates please email CV to: Chris.Mueller@umassmed.edu


Link: https://www.indeed.com/viewjob?jk=529c3289cc30c894&tk=1c9a9vpkj0keo44e&from=serp&vjs=3
Employer: University of Massachusetts Medical Center
Location: Worcester, MA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: March 21st, 2018
University of Massachusetts Medical CenterWorcester, MAPhDALSMar 21, 2018
Postdoctoral Fellow, Kalra Lab

Postdoctoral Fellow, Kalra Lab

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Description:

Postdoctoral positions are available in the ALS Neuroimaging Research Unit at the University of Alberta. The mission of the lab is to further our understanding of the biology of amyotrophic lateral sclerosis (ALS) using advanced MRI methods. The lab is directed by Dr. Sanjay Kalra, a neurologist and researcher, and the director of the Canadian ALS Neuroimaging Consortium (CALSNIC).


Areas of investigation include 1) Modeling of multimodal MRI data to quantify and characterize cerebral degeneration, 2) Development of novel image analysis methods as potential biomarkers, and 3) Ex-vivo validation of MRI metrics.


Qualifications:


• A PhD or equivalent in a relevant discipline such as computer science, biomedical or electrical engineering, medical physics, or neuroscience


• Experience with image analysis methods and tools (MATLAB, Unix, FSL, etc)


• Familiarity with DTI, structural and functional connectivity, magnetic resonance spectroscopy, cortical thickness estimation, or ex-vivo imaging is an asset


• Highly motivated and able to work collaboratively in a multidisciplinary environment


• Good written and verbal communication skills in English


Interested individuals should forward a CV and list of references with their email addresses to: Sanjay Kalra, MD FRCPC Professor, Department of Medicine University of Alberta sanjay.kalra@ualberta.ca


Link: http://www.alsresearchforum.org/wp-content/uploads/PDF-Kalra.pdf
Employer: University of Alberta
Location: Alberta, Canada
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: March 19th, 2018
University of AlbertaAlberta, CanadaPhDALSMar 19, 2018
Senior Research Investigator

Senior Research Investigator

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Description:

The Gene Therapy Program (GTP) and Orphan Disease Center (ODC) are entering a new era of unprecedented opportunity with great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases. Our R&D organization has a translational infrastructure that includes: technology discovery, specialized immunology assays operating under GLP, a Vector Core/Manufacturing unit that conducts GMP comparable work, and a large non-clinical program for animal testing under GLP including large NHP and rodent vivaria.


We are currently looking for Senior Research Investigator (SRI), Translational Research, to work in one of several therapeutic areas such as motor neuron, neurodegenerative, and/or therapeutic antibodies.

As a SRI, Translational Research, you will be involved in translation research projects in one or more therapeutic areas. In each case, you will be working in the setting of large interdisciplinary teams, where you will function independently in the execution of the experiments but will need to work collaboratively with other team members. Working independently, you will perform design, optimization and implementation of complex in vitro and in vivo experiments in rodents and NHP within specified timelines; provide cross-organizational support for the essential laboratory functions, including effective management of laboratory resources, and participation in maintenance of centralized reagents; contribute to writing/reviewing manuscripts, preparing presentations, establishing collaborations as well as writing/reviewing protocols and SOPs.


This position offers the opportunity to interface broadly internally & externally with diverse functional areas. Joining GTP offers scientific professionals the unique opportunity of seeing their research go from bench to bedside and discoveries that could one day lead to cures.

As a top candidate for this role, you will possess: Minimum of 5 years of experience after the completion of the PhD degree in the field of molecular biology, virology,biochemistry, enzymology, gene therapy, protein engineering, or related fields required.


Candidate must thrive in a team environment, have excellent written and oral communication skills, ability to prioritize in a fast-paced environment, and proficiency with standard methods of data analyses


Link: https://www.linkedin.com/jobs/view/308194466/
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: March 19th, 2018
University of PennsylvaniaPhiladelphia, PAPhDALSMar 19, 2018

Industry

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
Director, Antibody Discovery

Director, Antibody Discovery

(Click title to open job details in a new window.)
Description:

Voyager is seeking a highly motivated scientist and leader with extensive experience in therapeutic antibody discovery and development to contribute to our research team and build the Antibody Platform at the company.


This individual will build and lead a platform effort on antibody discovery and engineering including but not limited to AAV-vectorized antibodies, integrating both internal and external resources. Incumbent will also play an important role in business development opportunities and ongoing and future partnerships. The candidate should have substantial working familiarity and demonstrated success with state-of-the-art approaches for generating, selecting, humanizing and optimizing human antibodies and antibody fragments against targets of interest. These approaches include tools and systems such as transgenic mouse strains that produce human antibodies, high throughput hybridoma and B-cell cloning from immunized animals and from human samples, and display technologies for affinity maturation. Responsibilities will include the development of a strategy and implementation of plans for rapid advancement of the vectorized antibody platform, and oversight of a group responsible for activities that include hybridoma screening, antibody gene cloning and sequencing, recombinant antibody expression, antibody humanization, lead antibody identification, antibody optimization including affinity maturation, and antibody characterization. This is an ideal position for an individual who is energetic and thrives in a team-oriented, fast-paced, and cross-disciplinary small biotech company environment. This role is located in Cambridge, MA.


Link: https://www.linkedin.com/jobs/view/618406811/
Employer: Voyager Therapeutics
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: May 2nd, 2018
Voyager TherapeuticsCambridge, MAPhDNDGMay 02, 2018
Postdoctoral Fellow

Postdoctoral Fellow

(Click title to open job details in a new window.)
Description:

We are seeking a highly motivated postdoctoral associate interested in proteinopathy research in the context of neurodegenerative diseases. The successful candidate will be responsible for developing in vitro models to understand underlying mechanisms of pathogenic protein inclusion formation in the brain. The ideal candidate should have excellent communication and writing skills and the ability to work well in a multidisciplinary team. The candidate will periodically present his/her results and will prepare manuscripts for publication of findings in a peer-reviewed journal.


Link: https://sjobs.brassring.com/TGnewUI/Search/home/HomeWithPreLoad?PageType=JobDetails&partnerid=13617&siteid=5260&jobId=2555665
Employer: Novartis
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: May 2nd, 2018
NovartisCambridge, MAPhDNDGMay 02, 2018
Senior Scientist, Analytical Development

Senior Scientist, Analytical Development

(Click title to open job details in a new window.)
Description:

Voyager is seeking a highly motivated scientist to contribute to the Analytical Development group. The qualified candidate will participate in development, qualification, and transfer of new state-of-the-art analytical methods to be used for characterization and release of Voyager’s products. This role is currently an individual contributor but may expand to having direct reports in the future. This position is located in Cambridge, MA. Primary responsibilities include, but are not limited to, the following:


*Develop analytical methodologies and strategies needed to progress products in the pipeline including method development, process support, formulation and stability support, product characterization and method qualifications

*Develop cell-based bioassays for AAV viral vector products

*Revise, review, and author assay standard operating procedures

*Act as subject matter expert in providing analysis and data interpretation both internally and externally with CMO’s/CRO’s

*Manage and participate in tech transfer of analytical methods to CMO’s/CRO’s

*Develop and deliver scientific presentations, prepare clear and concise technical reports, participate in project teams, and contribute to regulatory filings


Link: https://www.linkedin.com/jobs/view/671598488/
Employer: Voyager Therapeutics
Location: Cambridge, MA
Sector: Industry
Degree required: PhD or MS
Conditions: ALS
Job posted: April 27th, 2018
Voyager TherapeuticsCambridge, MAPhD or MSALSApr 27, 2018
Senior Scientist

Senior Scientist

(Click title to open job details in a new window.)
Description:

Voyager Therapeutics is developing recombinant adeno-associated virus (rAAV) vectors for treating neurological diseases. Developing robust and reliable vector production processes is central for establishing successful gene therapy applications. Voyager is seeking a highly motivated Senior Scientist and/or Engineer to join the Process Development Group with a focus on upstream production. The qualified candidate will be a leader within the group with a strong background and expertise in cell culture manufacturing of biologics. Primary responsibilities will include carrying out upstream process development activities for the manufacture of pre-clinical and cGMP grade rAAV products, participating in and leading internal productions, writing appropriate documents and carrying out technology transfer to assorted CMOs, and finally participating in cGMP manufacture person in plant activities. The ability to independently organize and design experiments, analyze data and report the results of their and other’s work in a concise and well documented manner, and to take the initiative to successfully drive Voyager’s projects and manufacturing process are all important aspects of the position.


Ref# 18TO-CM002


To apply, email careers@voyagertherapeutics.com


Link: http://www.voyagertherapeutics.com/join-our-team/careers/
Employer: Voyager Therapeutics
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: ALS
Job posted: April 24th, 2018
Voyager TherapeuticsCambridge, MAPhDALSApr 24, 2018
Staff Scientist, Medicinal Chemistry

Staff Scientist, Medicinal Chemistry

(Click title to open job details in a new window.)
Description:

This lab-based chemist will be a key part of an interdisciplinary team of scientists and will be involved in the design, synthesis, purification, and characterization of novel drugs in the areas of neurodegenerative disease. In this dynamic team focused role, the qualified candidate will also be expected to manage and run the chemistry laboratory, and act as a mentor for junior chemists as needed.


Responsibilities include:


*Design, synthesis, purification, and characterization of novel drugs in the areas of neurodegenerative disease

*Scientist expected to independently drive research of a portion of the medicinal chemistry project team

*Act as a synthetic chemistry resource within the medicinal chemistry department to solve challenging synthetic problems that arise in our internal and external teams

*Contribute to the writing and execution of patent applications

*Work effectively with external collaborators and CROs

*Execute with significant initiative, ingenuity, efficiency, and speed

*Maintenance and troubleshooting of lab equipment (NMR, LCMS etc.)


Link: http://www.yumanity.com/careers/
Employer: Yumanity Therapeutics
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: April 20th, 2018
Yumanity TherapeuticsCambridge, MABS or MSNDGApr 20, 2018
Senior Scientist, Neuroscience

Senior Scientist, Neuroscience

(Click title to open job details in a new window.)
Description:

The Merck Early Discovery Neuroscience team is seeking a passionate, research focused and technically skilled in-vitro scientist with strong molecular, cellular and biochemistry expertise in neurodegenerative diseases to join our Boston-based research community. The high-level goal of the group is to effectively advance de novo discoveries from within the laboratory toward medicines to treat neurodegenerative diseases. The concentration of the group is centered on understanding the key determinants of microglia that impact their functional responses to neurodegenerative disease states. Mainly, how do genetic mutations in selected neuroimmune genes confer neurodegenerative susceptibility and by what common or unique mechanisms? By generating and characterizing transgenic models and developing cell-based systems, the team aims to gain insights into causal disease pathophysiology informed by human genetics using combinations of molecular and functional profiling technologies. Target, pathway and functional insights are pressure-tested with pharmacological, biologic and genetic experimental tools to validate insights and mechanistic hypotheses. A core part of the group mission and responsibility of the Senior Scientist is to establish, optimize and transfer insights and assays to enable target and pathway screening. To that goal, candidates with extensive expertise in cellular and molecular neuroscience with de novo assay development experience are encouraged to apply.


Link: https://jobs.merck.com/job/Boston-Senior-Scientist-Discovery-Neuroscience-MA-02108/471840600/
Employer: Merck
Location: Boston, MA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: April 19th, 2018
MerckBoston, MAPhDNDGApr 19, 2018
Senior Research Associate, Neurobiology

Senior Research Associate, Neurobiology

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Description:

Verge Genomics is seeking a Research Associate or Sr. Research Associate to join the Neurobiology Research and Drug Discovery team and contribute to innovative research in finding therapies to treat CNS diseases. This candidate will bring pharmaceutical industry experience to conduct in vivo and in vitro research in our SF Bay Area laboratories and join team meetings at Verge Genomics headquarters in SF. The qualified candidate will be highly motivated, interactive and creative with ability to work across functions and projects. The candidate is responsible for contributing to the execution of target validation and evaluation of novel drug candidates for neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Parkinson’s disease. The ideal candidate will have working knowledge of CNS disease and or mechanisms with existing and experimental therapeutic approaches. A keen ability to identify efficient solutions to laboratory problems and working knowledge with statistical analysis are essential. This position reports to the Director of Drug Discovery.


Link: https://www.linkedin.com/jobs/view/622106278/
Employer: Verge Genomics
Location: San Francisco, CA
Sector: Industry
Degree required: BS or MS
Conditions: ALS
Job posted: April 15th, 2018
Verge GenomicsSan Francisco, CABS or MSALSApr 15, 2018
Associate Scientist

Associate Scientist

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Description:

Yumanity is seeking an associate scientist to join our interdisciplinary team to help advance our novel drug discovery programs. This position will be laboratory based and requires experimental skills in human stem cell culture, including experience differentiating patient and control-derived progenitor cells into various central nervous system cells. This position will report to a Senior Scientist in Discovery Biology and will collaborate across all of Yumanity’s core platforms, including yeast phenotypic screening, target identification and chemistry.


Responsibilities include:

*Maintain induced pluripotent stem cells or embryonic stem cells and differentiate them into central nervous system cell types such as neurons, astrocytes, oligodendrocytes and microglia.

*Perform quality control measures for stem cells and differentiated cells.

*Support characterization and assay development of differentiated central nervous system cells.

*Interact and collaborate with yeast screening, target ID and medicinal chemistry teams to validate compound and target activities in mammalian cells.


Link: http://www.yumanity.com/careers/
Employer: Yumanity Therapeutics
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: April 13th, 2018
Yumanity TherapeuticsCambridge, MABS or MSNDGApr 13, 2018
Principal Scientist, Blood-Brain Barrier (BBB) Transport Technologies

Principal Scientist, Blood-Brain Barrier (BBB) Transport Technologies

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Description:

We are seeking an experienced scientist to join Biogen’s Biologics Drug Discovery Team, and contribute to our mission to design, optimize, and develop important protein therapeutics to improve the lives of patients with neurodegenerative disease. In this role, you will jointly lead a cross-functional effort to identify and validate novel methods for enhancing delivery of protein biologics to the central nervous system (CNS).


Link: https://sjobs.brassring.com/TGnewUI/Search/home/HomeWithPreLoad?PageType=JobDetails&noback=0&partnerid=169&siteid=5140&jobid=805613#jobDetails=805613_5140
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: April 13th, 2018
BiogenCambridge, MAPhDNDGApr 13, 2018
Scientist I, Analytical Development (Small Molecule + ASO)

Scientist I, Analytical Development (Small Molecule + ASO)

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Description:

The individual will develop, implement, and qualify innovative analytical solutions for the characterization and testing of ASOs and pharmaceuticals (both off-line and on-line). This work will support process and formulation development and will drive the control strategy. Key areas of focus will be in enhanced impurity monitoring, simple and specific identity testing, and evaluating novel formulations. The primary methods are HPLC/UPLC, MS, and spectroscopy, but the use of other methods is required and should be explored.


The work requires cross-functional interactions and the ability to work independently and creatively to influence stakeholders across the development organization. Excellent technical skills, the ability to think outside of the box, and the ability to drive experiments from proof of concept to implementation are required. The selected individual should be able to clearly communicate their results and accomplishments to a broad audience at team meetings and in written reports. Strong self-motivation and drive to make impactful contributions in a fast-paced environment is critical.


Qualifications


•In-depth knowledge of separation sciences, including (U)HPLC, GC, RP, IC, AEX, and chiral chromatography, and mass spectrometry with extensive laboratory experiences

•Hands-on experience with other characterization techniques such as NMR, Raman, IR, KF, etc.

•Ability to develop and qualify new analytical methods

•Strong problem-solving and troubleshooting skills, capabilities in experimental design and execution, as well ability to work independently are essential.

•Knowledge in drug substance /drug product processing and pharmaceutical sciences as they relate to ASOs and pharmaceuticals

•Knowledge in formulation development and experience in supporting the development of enabling formulations and analyzing drug delivery systems, such as microspheres and liposomes

•Proficient with a wide range of instrumentation platforms, e.g. Empower and ChemStation, and software applications, including Microsoft Office.

•Strong verbal and written communication skills, strong interpersonal skills and the ability to serve as a team member/leader in an environment where individual initiative, collaboration and accountability are valued.


Education


Ph.D. (preferred) in analytical chemistry, chemistry, pharmaceutical sciences, or related discipline with a minimum of 0-3 years experience OR MS Degree with a minimum of 5 years experience.


Link: https://sjobs.brassring.com/TGnewUI/Search/home/HomeWithPreLoad?PageType=JobDetails&noback=0&partnerid=169&siteid=5140&jobid=806754#jobDetails=806754_5140
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: April 13th, 2018
BiogenCambridge, MAPhDNDGApr 13, 2018
Senior Research Associate, Neuroscience

Senior Research Associate, Neuroscience

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Description:

Voyager is seeking a highly motivated biologist to contribute to our research team at our facility in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in in vitro and in vivoexperimental methods, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. The individual will work in the laboratory and be responsible for experimental execution, and data analysis for research studies supporting cutting edge therapeutic programs and platform discovery research in neurodegenerative disease areas. We are looking for extensive prior hands-on in with techniques such as cell culture, in vitro assay development and execution, CNS tissue preparation, qRT-PCR, western, and ELISA.


This role is located in Cambridge, MA and reports to a Principal Research Scientist.


Requirements



  • B.S. or M.S. in Biology or related discipline

  • Outstanding problem-solving skills

  • Ability to be highly productive in a fluid and fast-paced work environment

  • At least 5 years of hands-on experience with in vitro and in vivotechniques.

  • Experience with design, documentation and execution of experiments

  • Ability to independently analyze and present data to scientific team


Strongly Preferred



  • Working knowledge of AAV, cell culture and cellular biology

  • Familiarity with molecular and cell biology methods

  • Experience with drug discovery for neurodegenerative diseases

  • Experience on cross-functional therapeutic program team

  • Experience within a start-up or small biotech environment


Link: https://www.linkedin.com/jobs/view/597107321/
Employer: Voyager Therapeutics
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: April 5th, 2018
Voyager TherapeuticsCambridge, MABS or MSNDGApr 05, 2018
Scientist I, Biomarkers

Scientist I, Biomarkers

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Description:

The Discovery and Early Development Biomarkers group, part of Biogen’s Research and Early Development department is seeking a highly motivated scientist to join a dynamic team engaged in the discovery and progression of novel biomarkers for neurodegenerative diseases.


Responsibilities include executing experiments to identify, evaluate, and characterize relevant fluid biomarkers that will provide useful pharmacodynamic and efficacy endpoints in either preclinical or clinical settings. The successful candidate will be capable of multitasking and effective planning to consistently meet deadlines. Effective communication and collaboration are crucial.

•Protein biomarker immunoassay development using state of the art immunoassay platforms (i.e. Quanterix Simoa, Singulex Erenna, MSD) or high resolution LC-MS including: Sample preparation (tissues and cell lysates) for protein quantification. Biotinylation and various bead-antibody conjugation techniques. Identification and selection of antibodies for immunoassays. Identification of novel techniques and strategies to enhance assay sensitivity. Recognize and troubleshoot data anomalies to maintain high data quality. Timely recording keeping and data entry into Electronic Lab Notebook. Prepare, review, and deliver scientific presentations for internal/external use. Interact with various project teams as a liaison to share and distribute information. Commitment to help the team achieve deliverables and meet aggressive timelines in a fast-paced environment.


Link: https://sjobs.brassring.com/TGnewUI/Search/home/HomeWithPreLoad?PageType=JobDetails&noback=0&partnerid=169&siteid=5140&jobid=805617#jobDetails=805617_5140
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: March 30th, 2018
BiogenCambridge, MAPhDNDGMar 30, 2018

Non-Profit and Government

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
Director, Registry Operations

Director, Registry Operations

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Description:

The Registry Operations Director will direct and manage operations for MDA’s large, multi-disease Neuromuscular Observational Research (MOVR) Data Hub, a key element of MDA’s mission to improve patient outcomes and help drive drug development. This position works across multiple departments within MDA and with external stakeholders including, but not limited to, industry, governmental agencies, academic institutions and other non-profit organizations to build and maintain the MOVR Data Hub. This position will report directly to the SVP, Scientific Program Director.


Link: https://mda.jobs.net/en-US/job/registry-operations-director/J3M1LZ6QC72Q5W1D3F9
Employer: Muscular Dystrophy Association
Location: Boston, MA
Sector: Nonprofit
Degree required: BS or BSN
Conditions: NDG
Job posted: May 8th, 2018
Muscular Dystrophy AssociationBoston, MABS or BSNNDGMay 08, 2018
Senior Scientist

Senior Scientist

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Description:

Sage Bionetworks is recruiting a scientist with bioinformatics or computational biology experience to lead integrative genomic analysis within multiple consortia of biologists and computational biologists studying neurodegenerative and neuropsychiatric diseases.


Specific Responsibilities Include:


Job responsibilities include facilitating research between teams of scientists.  Including  implementing  analyses, coordination of consortium-wide analyses, and cross-project evaluation and integration of results. These projects will advance our molecular understanding of neurodegenerative and neuropsychiatric disease biology to eventually refine disease diagnoses or targeted therapeutic intervention.


Specific responsibilities will focus on leading efforts in analysis of primarily genomic data through the following activities:


•     Perform research through well-informed biological and methodological strategic decisions on analyses of genomic and/or imaging datasets.


•     Develop novel mechanisms to evaluate and combine outcomes across multiple lines of biological and statistical evidence


•     Develop visualizations


•     Create scientifically rigorous publications, communications and presentations


•     Lead integrated analytical efforts and interpretation of results across collaborators within consortia


•     Work with a high-degree of independence to complete and publish high quality research in a transparent, reproducible manner.


•     Coordinate data deposition and analytical outputs across multiple researchers


•     Utilize internally developed software tools to manage collaborations and work closely with the software team to provide feedback on the development of these tools.


Basic qualifications:


•     Ph.D. in bioinformatics, computational biology, genomics, computer science, statistics or relevant scientific discipline with 3+ years of relevant experience or MS with 5+ years of relevant experience.


•     Expertise in analyzing and interpreting at-least one of the high-throughput genomics data: next generation sequencing (DNA, RNA, methylation), SNP Arrays, mass spectrometry (proteomics, metabolomics).


•     Proficient in at least one of following programming languages: R, Python, or Matlab


Additional skills/Preferences:


•     Extended knowledge of statistical data analysis of genomic data


•     Track record of innovative publications in application of or methodological development of integrative analysis of high-dimensional data.


•     Expertise with integrative, mechanistic, network, and/or predictive modeling


•     Domain knowledge in neurobiology, neuropsychiatry or inflammatory disease.


•     Outstanding  ability to manage a cross-disciplinary group of researchers in a collaborative project


•     Experience communicating advanced scientific concepts to a broad audience


•     Experience with high performance compute or cloud computing


Link: https://sagebase.clearcompany.com/careers/jobs/567fa130-6578-58a9-f671-38e3fabbaf7b/apply?source=676017-CS-28397
Employer: Sage Bionetworks
Location: Seattle, WA
Sector: Nonprofit
Degree required: PhD
Conditions: NDG
Job posted: May 7th, 2018
Sage BionetworksSeattle, WAPhDNDGMay 07, 2018
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