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Postdoctoral Fellow, Neurotherapeutics

The research at the Division of Protein Technology is to a large extent focused on development of affinity proteins, including design and engineering of new functions and properties. Affinity protein development is a growing research discipline worldwide with applications in several fields such as biotech and medicine. The group of Biotherapy and Bacterial display has wide experience in combinatorial protein engineering of affinity proteins and has developed methods for such purposes exploiting both phage and bacteria.

Computational Neuroscientist

The Krembil Research Institute at the University Health Network in Toronto Canada invites applicants to apply for a Scientist position in the area of Computational Neuroscience. The ideal candidate will have a PhD in a relevant field, research expertise and experience in mathematical and computational modeling, and research interests that complement those of the Institute in neurobiology and neurodegeneration. Candidates whose research interests encompasses cellular, micro/macro circuits and/or large scale brain models, and who have collaborative experimental experience are especially encouraged. The successful candidate will have the ability to establish an independent, well-funded program and will be eligible for appointment at the appropriate level within the University of Toronto.

Postdoctoral Fellow, Talbot Lab

An exciting opportunity has arisen to work as a Postdoctoral Researcher in Neurodegeneration in the Oxford Motor Neuron Disease Centre based in the John Radcliffe Hospital, Oxford. Working with Professor Kevin Talbot your research will investigate the mechanisms of motor neuron disease in amyotrophic lateral sclerosis using a novel BAC transgenic mouse, based on a mutation in TDP-43. Specifically, we will characterise the contributions of motor neuron-specific and non-cell autonomous effects of mutant TDP 43 on disease onset and progression in the TDP-43M337V BAC transgenic mouse, by inactivating the mutation in neurons or glia respectively, using the Cre-loxP system. Cell co-culture (directly or indirectly through conditioned media) of primary embryonic mouse motor neurons and microglia from these mice, will allow further characterisation of the relative effects of motor neuron-specific or microglial-specific expression of mutant TDP-43 on motor neuron function, morphology and survival, and TDP-43 cytoplasmic mislocalisation.

Professor

Building on world class expertise in genetics and immunology, the UK DRI at Cardiff University are looking for a dynamic, innovative dedicated individual who will contribute across the UK DRI as well as within the host centre. You will direct an internationally competitive research programme within the UK Dementia Research Institute (UK DRI) relevant to the area of neurodegeneration, with the ultimate aim of improving human health. Drawing on the knowledge and expertise of other colleagues both within and outside of the UK DRI through collaborative inputs and team working. The UK DRI is looking to transform the field of dementias research and welcomes scientists from all disciplines including frontotemporal dementia.

Group Leader, Neurogenomics

Expressions of interest are invited from suitably qualified scientists wishing to develop their scientific research career as Group Leader, Neurogenomics at the Garvan Institute of Medical Research, Sydney, Australia.

Postdoctoral Fellow, Gao Lab

A postdoctoral position is immediately available in the laboratory of Dr. Fen-Biao Gao at the University of Massachusetts Medical School to study molecular pathogenic mechanisms of fronototemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).

Director, Waisman Center

The Waisman Center is dedicated to the advancement of knowledge about human development, developmental disabilities, and neurodegenerative diseases throughout the lifespan. The Center is one of 14 national Intellectual and Developmental Disabilities Research Centers and also encompasses a federally funded University Center for Excellence in Developmental Disabilities. The Waisman Center provides an interdisciplinary research environment for over 50 faculty representing 20 academic departments of the University of Wisconsin-Madison and approximately 600 faculty, staff, graduate students, and postdoctoral fellows. The Waisman Center clinics and support programs serve more than 4,000 people with developmental disabilities a year.

Assistant, Associate or Full Professor

The Department of Anatomy and Cell Biology at the University of Illinois at Chicago (UIC) is seeking applications for outstanding candidates for tenure track positions at the Assistant, Associate and Full Professor ranks in the field of Neuroscience. We seek candidates with a record of innovative basic and/or translational Neuroscience research including fundamental questions in cellular and systems neuroscience. Areas of interest include but are not limited to:

Neuropathologist

The Department of Pathology and Laboratory Medicine at the University of California (UC) Davis, School of Medicine is seeking a dynamic academic physician-investigator to provide clinical service and teaching in neuropathology, and who can develop an independent hypothesis-based research program in an area of neuroscience, such as Alzheimer’s disease or other neurodegenerative conditions, autism/neurodevelopmental disorders, neoplastic neuropathology. The expectation is that the candidate will spend approximately 30-50% clinical service and teaching and 50-70% research. Clinical duties will focus on surgical and autopsy neuropathology, though other subspecialty areas of anatomic pathology could be also considered based on the candidate’s training and interests. Teaching duties may include clinical, didactic, laboratory and small group teaching of housestaff, medical students, graduate students, and students in other health professional programs, and participation in interdisciplinary clinical conferences.

Assistant Professor, Developmental and Translational Neurobiology

The Virginia Tech Carilion Research Institute (VTCRI) has launched a new center within the institute – the Developmental and Translational Neurobiology Center (DTNC; https://wp.vtc.vt.edu/dtnc/), to expand the institute’s research programs in cellular and molecular neurobiology in healthy development, disease, and trauma. There are currently two open assistant professor faculty positions – one for a neurobiologist studying mechanisms underlying brain development or neurodevelopmental disorders and one for a neurobiologist or neuro-immunologist studying neurodegenerative disease or brain injury. Applicants should have an earned doctorate, have completed postdoctoral training and demonstrated a track record of successful research, publications and either active extramural funding (preferably from NIH) or show distinct promise to obtain such funding. The new faculty will join a collaborative and highly successful group of investigators at the VTCRI with related research interests in a variety of areas of neuroscience. Competitive salary, space and start-up packages will be provided.

Assistant Professor, Developmental and Translational Neurobiology

The Virginia Tech Carilion Research Institute (VTCRI) has launched a new center within the institute – the Developmental and Translational Neurobiology Center (DTNC; https://wp.vtc.vt.edu/dtnc/), to expand the institute’s research programs in cellular and molecular neurobiology in healthy development, disease, and trauma. There are currently two open assistant professor faculty positions – one for a neurobiologist studying mechanisms underlying brain development or neurodevelopmental disorders and one for a neurobiologist or neuro-immunologist studying neurodegenerative disease or brain injury. Applicants should have an earned doctorate, have completed postdoctoral training and demonstrated a track record of successful research, publications and either active extramural funding (preferably from NIH) or show distinct promise to obtain such funding. The new faculty will join a collaborative and highly successful group of investigators at the VTCRI with related research interests in a variety of areas of neuroscience. Competitive salary, space and start-up packages will be provided.

Assistant Professor, Genetics

The Centre for Integrative Biology of the University of Trento invites candidates active in Genetics to apply for a position at the Assistant Professor level. The position is offered for a three-year period. The annual gross salary will be about 45.000 Euros. The area of research and teaching is Genetics:

Assistant Professor, Neuroinflammation Research

The BARROW NEUROLOGICAL INSTITUTE seeks an exceptionally promising or accomplished investigator to study neuroinflammation and complement other translational neuroscience research in a unique and dynamic environment within the Division of Neurobiology at the Barrow Neurological Institute (https://www.barrowneuro.org/).

Assistant Professor, Neuroscience

In a major Neuroscience initiative, we seek to hire up to 2 tenure-track or tenured faculty members as part of a cross campus multi-disciplinary effort to study the nervous system (from development, to function, to aging, degeneration and repair). We seek researchers that collectively span multi-disciplinary levels of investigation (molecular mechanisms, circuit analysis, complex animal and human behaviors) using state of the art techniques (molecular, optogenetics, behavioral, educational, computational, imaging, EEG, genetic and research of clinical populations) applied to experimental model systems of health, injury and disease (invertebrate, vertebrate or human systems). Our goal is to recruit a team of collaborative individuals with an outstanding record, committed to excellence in research, that complement existing campus strengths. Applicants for tenured positions should also demonstrate notable scientific contributions and sustained extramural support. Successful candidates must also have clear potential or demonstrated ability to work successfully with and benefit a diverse student body.

Assistant Professor, Neuroscience and Cell Biology

Specific Job Related Duties

Assistant Project Manager – NEALS

The Neurological Clinical Research Institute (NCRI) develops, designs, supports and manages innovative observational and interventional trials for neurological disorders. This fast paced institute has an impressive record of efficiently organizing, overseeing, coordinating, and conducting small and large multi-center, international clinical trials. The mission of the NCRI is to accelerate translational research in neurological disorders through initiating and testing novel therapies. The NCRI also serves as a Coordinating Center for the Northeast ALS Consortium (NEALS), a non-profit, research consortium committed to the cooperative implementation, timely completion, analysis, and reporting of clinical trials and other research studies aimed at improving patient care and understanding of the disease process of Amyotrophic Lateral Sclerosis (ALS).

Assistant or Full Professor, Chemical Biology

Sanford Burnham Prebys Medical Discovery Institute (SBP) is an independent non-profit biomedical research institute that blends world-class fundamental research with drug discovery to address unmet clinical needs in the areas of cancer, neuroscience, immunity, and metabolic disorders. The Institute invests in talent, technology, and partnerships to accelerate the translation of laboratory discoveries that will have the greatest impact on patients. Recognized for its world-class NCI-designated Cancer Center and the Conrad Prebys Center for Chemical Genomics, SBP employs more than 1,100 scientists and staff in La Jolla (San Diego), California, and Lake Nona (Orlando), Florida.

Assistant, Associate or Full Professor, Chemical Neuroscience

The Department of Medicinal Chemistry at the University of Minnesota invites applications for a tenure-track faculty position at the rank of Assistant, Associate, or Full Professor level. The Department is housed in the College of Pharmacy (CoP), which is ranked #2 in the Nation as a Top Pharmacy School and #3 in research funding among its peers. The position will be a twelve-month full-time appointment, with expectations in teaching (in the areas of Medicinal Chemistry & Neuroscience) and service to both the PharmD professional curriculum and also the Departmental graduate education programs. Candidates are expected to establish, maintain, and direct a major research program addressing chemical neuroscience from a medicinal chemistry/chemical biology perspective to interface with other activities within the University of Minnesota, the CoP, and the Institute for Translational Neuroscience (https://www.med.umn.edu/research/research-strengths-expertise/neuroscience/institute-translational-neuroscience ). Emphasis is placed on research in neurodegenerative disorders, epilepsy, psychiatric diseases, neuroaddiction, and neuroendocrinology, but all neuroscience sub-disciplines are encouraged to apply. Interested candidates are strongly encouraged to apply by December 15, 2016 for the first review; however, this position will remain open until filled.

Assistant, Associate or Full Professor, Environmental Health

The Department of Environmental and Occupational Health (EOH) within the Robert Stempel College of Public Health & Social Work (RSCPHSW) at Florida International University (FIU) invites applications for two tenured/tenure-track faculty member at the Assistant/Associate/Professor rank (rank and tenure commensurate with qualifications).

Assistant, Associate or Professor, Pharmacology

The University of Southern California (USC) Titus Family Department of Clinical Pharmacy invites applications for a tenured/tenure track position at the rank of Assistant, Associate or Professor. Individuals with research interests in pharmacogenomics, pharmacometrics, bioinformatics, or medication safety are encouraged to apply.

Associate Director or Senior Manager, Business Development and Alliance Management

In conjunction with and reporting to the Sr. Vice President of Business Development, the Senior Manager/Associate Director, Business Development and Alliance Management will focus on building value through strategic alliances and/or licensing transactions.

Associate Professor, Cognitive Neuroscience

The Department of Psychiatry & Behavioral Sciences and the Cognitive Neurology and Alzheimer’s Disease Center at the Northwestern University Feinberg School of Medicine are jointly searching for a cognitive neuroscientist. The successful candidate will have the credentials for a full-time tenure-track appointment (Investigator Track) at the level of Associate Professor. The candidate will have the capability to lead an independent laboratory on the experimental neuropsychology and multimodal imaging of neurodegenerative diseases and successful aging. Established track record of research achievements in these areas and expertise on the cognitive aspects of aging and dementia are desirable. The successful candidate will contribute to the academic mission of the Clinical Psychology Doctoral Program within the Department of Psychiatry and will lead his/her research program on dementia and aging within the Cognitive Neurology and Alzheimer’s Disease Center. The start date is negotiable and the position will remain open until filled.

Associate Scientist II, ALS

The Department of Neurology Research is seeking a highly talented and enthusiastic associate to join an in vitro / in vivo target discovery and validation effort in Amyotrophic Lateral Sclerosis (ALS) aimed at bringing new targets and therapeutic strategies from discovery to development. The successful candidate will be expected to support efforts to develop and validate new in vitro ALS models for candidate identification and validate findings in primary mouse tissue.

Associate Scientist II, Neuroimmunology, Research

The Neuroimmunology department at Biogen is searching for a committed, enthusiastic and dependable associate scientist to assist with the design, execution and interpretation of preclinical studies for drug discovery and development. The incumbent will be part of a multifunctional team with responsibility for target validation and evaluation of novel drug candidates for neurodegenerative/neuroinflammatory diseases. He/she should be able to plan and execute in vivo and in vitro experiments with high level of independency, organization and scientific rigor. He/she should be able to maintain an up-to-date knowledge of pertinent literature and possess excellent communication and interpersonal skills to efficiently present results to project team members.

Associate Scientist III, Neuroimmunology

The Biogen Department of Neuro/Immunology seeks a highly motivated and keen associate scientist whose primary responsibility is to advance target validation, drug discovery and development. The individual is expected to have mastered a broad range of experimental techniques, preferably having established expertise in the field of neuroimmunology. The individual will be expected to perform with significant independence with respect to designing and executing controlled experiments, analyzing and interpreting results, establishing and executing existing or new protocols/methodologies and recommending modifications. The individual is expected to read pertinent literature and exhibit knowledge of molecular and biological processes, applying their knowledge to propose new ideas and regularly make suggestions for creative solutions to technical challenges. The individual is expected to have strong written and verbal communication skills, preparing and delivering oral presentations, posters, draft research reports and contributing to manuscripts.

Associate or Full Professor, Neuroscience

In a major Neuroscience initiative, we seek to hire up to 2 tenure-track or tenured faculty members as part of a cross campus multi-disciplinary effort to study the nervous system (from development, to function, to aging, degeneration and repair). We seek researchers that collectively span multi-disciplinary levels of investigation (molecular mechanisms, circuit analysis, complex animal and human behaviors) using state of the art techniques (molecular, optogenetics, behavioral, educational, computational, imaging, EEG, genetic and research of clinical populations) applied to experimental model systems of health, injury and disease (invertebrate, vertebrate or human systems). Our goal is to recruit a team of collaborative individuals with an outstanding record, committed to excellence in research, that complement existing campus strengths. Applicants for tenured positions should also demonstrate notable scientific contributions and sustained extramural support. Successful candidates must also have clear potential or demonstrated ability to work successfully with and benefit a diverse student body.

Biocuration Scientist

The Biocuration Scientist is responsible for the ongoing curation of scientific databases and directories that serve the neurodegeneration research community. The databases reflect the breadth of AD research and include information on research models, mutations, biomarkers, therapeutics, and other aspects of research on AD and related disorders. The Biocuration Scientist collaborates with the scientific content manager and other Alzforum staff members to ensure that information is accurate, up to date, and consistent across the website.

Bioinformatician, Salomoni Lab

We are seeking an interactive and self-motivated Bioinformatician / Computational Biologist to join a team of cell and molecular biologists working on brain pathophysiology. The projects will focus on interrogating and integrating existing and new genetic and epigenetic datasets generated from genetically engineered mouse models as well as primary human samples. This programme of work is based on published/unpublished work from the team. This work will be conducted by Professor Paolo Salomoni whose research interest is nuclear function in regulation of cell fate in normal brain and CNS disease.

Biostatistician

The Biostatistician is responsible for providing statistical support to nonclinical and biomarker studies or projects as assigned. He/She participates in activities in cross-functional project teams for study design and execution. He/She provides statistical consultation to teams, and ensures the incorporation of statistical input in study design and execution. He/She develops statistical analysis plans and performs statistical analyses, interprets statistical results.

Biostatistician, Research Fellow

Applications are invited for a motivated and self-driven individual for the position of Biostatistician with the Irish ALS Research Group, hosted in the Trinity Biomedical Sciences Institute’s Academic Unit of Neurology. This project will combine high resolution structural and dynamic imaging of the brain at 3 Tesla and spectral EEG/ EMG with clinical and genomic data to identify sub-clusters of ALS patients.

Chair, Department of Neuroscience

The UConn School of Medicine is seeking an outstanding neuroscientist at a rank of Associate or Full Professor to become Chair of the Department of Neuroscience. Candidates with nationally recognized accomplishments in research, sustained NIH or extramural funding, and leadership experience are encouraged to apply. Desired areas of expertise include but are not limited to cellular and molecular neuroscience, chronic and neurodegenerative diseases, brain circuitry research, and neurogenesis and regeneration. This position is ideal for an energetic individual with the leadership skills and vision required to foster the health and growth of a department that values academic excellence and collaboration. The departmental faculty excel in a variety of research areas (neuroscience.uchc.edu), lead educational programs in the graduate, medical and dental schools, and provide a stimulating environment for research trainees.

Chair, Department of Neuroscience

The UConn School of Medicine is seeking an outstanding neuroscientist at a rank of Associate or Full Professor to become Chair of the Department of Neuroscience. Candidates with nationally recognized accomplishments in research, sustained NIH or extramural funding, and leadership experience are encouraged to apply. Desired areas of expertise include but are not limited to cellular and molecular neuroscience, chronic and neurodegenerative diseases, brain circuitry research, and neurogenesis and regeneration. This position is ideal for an energetic individual with the leadership skills and vision required to foster the health and growth of a department that values academic excellence and collaboration. The departmental faculty excel in a variety of research areas

Clinical Psychologist

We are seeking a Clinical Psychologist with a strong interest in neuroscience and experience in neuropsychological assessment to join a well-established multidisciplinary neuroscience team specialising in early onset and/or rare dementias.

Clinical Research Coordinator

Cedars-Sinai Department of Neurology neuromuscular group is looking for an experienced Clinical Research Coordinator to join their research team. We are currently recruiting for over 10 protocols which include repositories, natural history studies, and interventional trials including pharmacological and surgical approaches.

Clinical Research Coordinator

The University of Miami’s Division of Neuromuscular Disorders in the Department of Neurology is seeking a full time Clinical Research Coordinator. The primary focus of the work will be on investigator-initiated research in the fields of amyotrophic lateral sclerosis (ALS) and myasthenia gravis (MG). To effectively perform in this position, the Clinical Research Coordinator will ideally have experience working on investigator-initiated clinical research projects, to be able to work independently with minimal supervision and to function effectively as part of a team.

Clinical Research Fellow, Neuromuscular Diseases

We now offer a unique opportunity to an academic clinical neurologist to join our team as a Clinical Research Fellow in Neuromuscular Diseases. During a negotiable 1-2 year commitment based at Cytokinetics’ offices in South San Francisco, the Fellow will contribute invaluable expertise to our clinical development programs in neuromuscular diseases. The Fellow will benefit from an experience rarely available in a strictly academic position; i.e., the day-to-day leadership and management of a clinical trial aimed at the development of new therapeutics for patients. The Fellow may engage in this opportunity in the context of their academic fellowship as a means to satisfy a research requirement if agreeable to their institution. Continued involvement in the clinical management of patients during the period of this fellowship will be encouraged. The Fellow may return to his or her academic post at the conclusion of the term, enriched by this experience in addition to returning to the parent institution with a portfolio of valuable clinical research competencies.

Computational Biologist

Verge Genomics is looking for a genomics scientist to develop algorithms, statistical methods, and software to analyze large-scale gene expression and genomic datasets. You will implement these methods to identify new disease targets and mechanisms, and drugs that target these disease gene networks. As one of the first employees at Verge, you will develop cutting-edge methods that will serve as the foundation of a revolutionary drug development model.

Director of Clinical Operations

At Alector, we believe that neurodegeneration and dementia, are in fact immune disorders and we made it our mission to empower the immune system to cure Alzheimer’s disease, frontotemporal dementia, ALS and other degenerative brain conditions. We are supported by leading investors in healthcare including Orbimed, Polaris, Google Ventures and count some of the most innovative pharma companies as our strategic backers.

Director of Neurodegeneration Disease Models

Alector is looking for exceptional scientists, senior scientists, and director-level investigators with a PhD and/or MD, an outstanding publication and track record, and a drive to innovate. The candidate must have extensive, hands-on expertise in conducting and managing disease model studies for neuro-degeneration and dementia, including Alzheimer’s disease, Parkinson’s disease, Frontotemporal dementia and ALS, in rodents. The successful candidates will play leading roles in the discovery and development of novel, disease-modifying drugs.

Director of Neurodegenerative Research

We are currently on the hunt for a Director of Research– Neurodegenerative to oversee all aspects of neurodegenerative gene therapy research at the GTP at PENN. In this role, you will be responsible for build a team of Senior Research Investigators (SRI) to support GTP’s Neurodegenerative research efforts; establishing processes for mentoring and leading SRIs in research projects; directly oversee and manage a team of SRIs and technicians; In consultation with the PI of the GTP, the Research Director – Neurodegenerative will assess the rare disease programs that are brought into GTP for scientific research. The individual should have in-vivo pharmacology expertise for preclinical translational programs as well as expertise in testing the efficacy of therapeutic interventions for neurodegenerative disease indications. Joining GTP offers scientific professionals the unique opportunity of seeing their research go from bench to bedside and discoveries that could one day lead to cures.

Director, Clinical Pharmacology

Reporting to the EVP Research & Development, the Director, Clinical Pharmacology will be responsible principally for early clinical drug development activities with a strong focus on Phase I and Phase IIa clinical trials. He/She will work closely with the Clinical Research Group and other members of the R&D team to ensure a strategic view is taken for the pipeline progression of individual projects.

Director, Institute of Biotechnology

Helsinki Institute of Life Science HiLIFE of the University of Helsinki is seeking a Director of the Institute of Biotechnology (bi.helsinki.fi). The Institute of Biotechnology (BI) is at the forefront of molecular biology research with eight current ERC grantees, and has a strong focus in biotechnology through developing new strategies e.g. to combat neurodegenerative and metabolic diseases. Current research programs at the BI are in Cell and Molecular Biology, Developmental Biology, Genome Biology, and Structural Biology and Biophysics. BI is an international, competitive and rewarding workplace, where the staff within the 25 research groups and 7 core facilities exceeds 250 and comes from 30 different countries. As of 2017 the Institute of Biotechnology is a unit of HiLIFE (www.helsinki.fi/hilife) and collaborates locally across life science units and organizations.

Director, Neurobiology

Verge Genomics is seeking a motivated and accomplished Director of Neurobiology with experience using in vivo pharmacology models to translate in vitro compound hits to optimized drug leads. You will lead in vivo studies to validate small molecule efficacy and minimize side effect potentials and establish proof of concept by the manipulation of gene targets to ameliorate or create disease models. The ideal candidate will apply a combination of his or her expertise in the etiology and treatment of ALS, Parkinson’s and Alzheimer’s disease, results from our cell-based screens, and animal studies you will lead to best apply gene networks to guide our drug discovery efforts. With knowledge of neuropharmacology and experience translating compound discoveries to CNS applications, this position offers the opportunity to help lead the neurobiology research program at an emerging biotech company.

Director, Neuropharmacology

The Neuropharmacology Research group is seeking independent and motivated scientists to join a newly established research team focused on the rapid progression of novel therapeutics to humans for neurodegenerative, neurobehavioral and neuromuscular diseases. The Director, Neuropharmacology will be responsible for establishing and leading a research pharmacology group responsible for developing and leading innovative approaches to the treatment of neurodegenerative, neurobehavioral and neuromuscular disorders. The candidate will be expected to lead their own research project, as well as oversee other drug development programs with the goal of building a robust and sustainable portfolio of candidates for clinical development. The candidate will also oversee the efforts and be responsible for guiding the career development of 6-10 scientists.

Director, Neuroscience Research & Drug Discovery

Verge Genomics is seeking a motivated and highly accomplished “drug hunter,” responsible for directing, managing, and leading basic research and drug discovery efforts for neurodegenerative diseases and leading multidisciplinary project teams. This position offers the opportunity to grow and lead a drug discovery program at an emerging biotech from the ground up, while establishing important external partnerships. As a member of the early team at Verge, you will be deeply involved in key strategic decisions and in organization of the research & discovery team, and help build the foundation of a revolutionary drug development model.

Director/Senior Director of Neurodegeneration and Repair Research

We are looking for a talented leader to direct preclinical research in Dementia and Memory Disorders within the new Neurodegeneration and Repair Research Unit. In close partnership with the early clinical lead for within the same unit, the successful candidate will be responsible for delivering innovative drug candidates for proof-of-concept trials in AD, FTD and other memory disorders. He/she will lead the efforts of multiple research teams from early target discovery to late preclinical development and support the clinical trial strategy. We seek a candidate with knowledge of the biology of neurodegeneration and an outstanding track record in the field of drug development. He/she will succeed by collaborating closely with other Biogen scientists and clinicians in the areas of neurodegeneration, neuroimmunology and repair, as well as experts in the multiple therapeutic modalities – small molecules, antibodies, biologics, antisense oligonucleotides and gene therapy – in the Biogen portfolio. An innovative approach to biomarker and drug delivery strategies will also be required. We particularly seek candidates who have demonstrated strong scientific rigor while exploring novel pathways and mechanisms in humans and model systems and in leading multidisciplinary research teams. Demonstrated expertise in Alzheimer’s research and experimental models would be an advantage but is not required.

Director/Sr. Director, Neurodegeneration and Repair Research

We are looking for a talented leader to direct preclinical research in Dementia and Memory Disorders within the new Neurodegeneration and Repair Research Unit. In close partnership with the early clinical lead for within the same unit, the successful candidate will be responsible for delivering innovative drug candidates for proof-of-concept trials in AD, FTD and other memory disorders. He/she will lead the efforts of multiple research teams from early target discovery to late preclinical development and support the clinical trial strategy. We seek a candidate with knowledge of the biology of neurodegeneration and an outstanding track record in the field of drug development. He/she will succeed by collaborating closely with other Biogen scientists and clinicians in the areas of neurodegeneration, neuroimmunology and repair, as well as experts in the multiple therapeutic modalities – small molecules, antibodies, biologics, antisense oligonucleotides and gene therapy – in the Biogen portfolio. An innovative approach to biomarker and drug delivery strategies will also be required. We particularly seek candidates who have demonstrated strong scientific rigor while exploring novel pathways and mechanisms in humans and model systems and in leading multidisciplinary research teams. Demonstrated expertise in Alzheimer’s research and experimental models would be an advantage but is not required.

Electrophysiologist

The Musculoskeletal disease area research department at the Novartis Institutes for BioMedical Research (NIBR) in Basel, Switzerland, is looking for a Scientific Associate with excellent electrophysiology skills to join a highly motivated research team that aims to identify and develop therapies for neuromuscular diseases and peripheral neuropathies like amyotrophic lateral sclerosis and sarcopenia.

Faculty Position – Assistant Professor, Neuroinflammation Research

Faculty Position – Dept. of Neuroscience

The Department of Neuroscience at Mayo Clinic in Jacksonville, FL, is seeking outstanding candidates with dynamic research programs in neurobiology of disease and aging. The ideal candidate for this position will be an investigator with an innovative and dynamic research program that is directed at understanding the fundamental role of disease biology in neurodegenerative disease including Alzheimer’s disease, Parkinson’s disease, Frontotemporal dementia, and Amyotrophic Lateral Sclerosis. Specific areas of interest include cerebrovascular disease, CNS immunity, neurobiology of aging, stem cell biology, neurodegeneration and neuroregeneration across a range of neurological disorders. We are seeking a world-class researcher to participate in departmental and institutional initiatives emphasizing collaboration and team science.

Faculty Position – Neuroinflammation Research

The BARROW NEUROLOGICAL INSTITUTE seeks an exceptionally promising or accomplished investigator to study neuroinflammation and complement other translational neuroscience research in a unique and dynamic environment within the Division of Neurobiology at the Barrow Neurological Institute (https://www.barrowneuro.org/).

Genetic Counselor

Working in the Neurological Clinical Research Institute (NCRI) at Massachusetts General Hospital (MGH) the genetic counselor will collaborate with and support the Amyotrophic Lateral Sclerosis (ALS) multidisciplinary clinical research team. The incumbent must have prior genetic counseling experience and a desire to be a key component of a team working to define the field of ALS genetics research. The majority of work will remain in the research realm; however, there will be opportunity to assist with complex ALS cases within the MGH ALS Multidisciplinary clinic or MGH Brain Health Clinic.

Graduate Research Assistant

The laboratory is seeking a motivated Graduate Research Assistant to join our efforts in exploring disease mechanisms and developing therapeutic strategies for amyotrophic lateral sclerosis (ALS) and dementia. There is an increased focus on altered RNA processing as a central component of neurodegeneration in ALS and frontotemporal dementia. Our group explores the role of RNA alterations in neuronal death and uses splicing and expression profiles to identify therapeutic strategies that correct disease-linked gene expression events. The successful candidate will lead a research project using various cellular and animal models of ALS to explore disease mechanisms. Under the supervision of the Principal Investigator, the candidate will design and perform experiments, will participate to the scientific lab meetings and is expected to fully participate in the organization and joint upkeep of the laboratory. He/She will perform laboratory experiments which include DNA and RNA purification, quantitative PCR, gel electrophoresis, Western blots, DNA cloning, immunostaining, preparation of libraries for high throughput sequencing, and mammalian cell cultures. Experience in mouse handling and mouse histology is preferred. The individual must pay attention to details, be capable of working independently under minimal supervision, possess good verbal and written communication skills, and work well as part of a team.

Graduate Studentship, Basso Lab

The major focus of the project is on extracellular vesicles and motor neuron degeneration with a particular interest on the role of RNA in the glia-motoneuronal intercellular communication. The PhD student will acquire expertise on extracellular vesicles analysis, RNA profiling in the field of neurodegeneration.

Graduate Studentship, De Vos Lab

Applications are now being invited for a three-year Basic Science PhD Studentship funded by Alzheimer’s Society, starting in October 2017. The successful candidate will join an established training programme at the Sheffield Institute for Translational neuroscience (SITraN) in the group of Dr Kurt De Vos. Expansions of a noncoding GGGGCC hexanucleotide repeat in the C9ORF72 gene are the most common genetic defect found to date in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). How the repeat expansion causes disease is not known, but appears to involve both loss-of-function (C9ORF72 haploinsufficiency), and gain-of-function (repeat-associated non-ATG (RAN) translation, RNA toxicity) mechanisms. To unravel the ways in which C9orf72 expansions cause disease it is crucial to understand the normal functions of the C9orf72 protein. In this project we will investigate how the cellular levels of C9orf72 are regulated and leverage this knowledge to devise novel therapeutic strategies. Candidates must have a first or upper second class honors degree or significant research experience.

Graduate Studentship, Maudsley Lab

The aim of this project is to disentangle the converging molecular pathomechanisms in the frontotemporal dementia – amyotrophic lateral sclerosis spectrum. We will pursue this goal by investigating different mouse models using state-of-the-art proteomic and transcriptomic technologies. Using this approach, we intend to unravel the disease mechanisms already at presymptomatic stages.

Graduate Studentship, Vande Velde Lab

Dr. Christine Vande Velde is looking to recruit a graduate student to her laboratory located at the CRCHUM facility, a research center affiliated with the Université de Montréal and located in Downtown Montreal.

Group Leader, Translational Biomarkers

Denali Therapeutics is seeking to recruit a Group Leader to lead the company’s translational biomarker efforts. S/he will be responsible for leading translational biomarker strategies and developing and implementing biomarker assays to assess the target engagement and PK/PD/response relationships of drug candidates in both preclinical models and clinical trials.

Lab Manager

The position is for a Lab Manager to help facilitate all daily lab operations. The individual will report to a Principal Investigator (PI) in neuropathology research that investigates the pathogenesis of Alzheimer’s disease, frontotemporal dementia, and related disorders. A successful candidate will have excellent communication skills, highly confident decision making ability, experience managing multiple projects and life sciences lab management, and embrace the highly dynamic environment.

Lab Manager, Neurosciences Clinical Research Unit

The position is responsible for, and critically important to Neurosciences Clinical Research Unit (NCRU), and Memory and Aging Center (MAC) investigators for the overall operational management of clinical research activities for the biospecimens processing lab. The Lab Manager has direct responsibility for implementing a diverse portfolio of processing protocols which include multicenter clinical trials (both NIH and industry-sponsored), local investigator-initiated clinical trials, and clinical research activities, including a clinical database and biorepository LIMS system.

Lab Technician, Grinberg Lab

The position is for a part time Lab Technician / Staff Research Associate I (SRA I) to assist the Principal Investigator (PI) in neuropathology research that investigates the pathogenesis of Alzheimer’s disease, frontotemporal dementia, and related disorders at UCSF Mission bay campus ( see http://grinberglab.ucsf.edu). The candidate is expected to be open to learning new methods.

Neurobiology Research Associate II

Verge Genomics is seeking a Neurobiology Research Associate II to join the Drug Discovery team. This candidate will gain pharmaceutical industry experience in a cutting-edge academic lab in the SF Bay Area and at Verge Genomics headquarters in SF. The candidate will be part of a multifunctional team with responsibility for target validation and evaluation of novel drug candidates for neurodegenerative diseases. The candidate will conduct in vivo studies in mice, including neonatal intracerebroventricular injections, and drug administration by oral routes. Experience with stereotaxic surgery, gene therapy (AAV9 or ASO), behavioral observations, gait analysis, rotarod and grip strength, and genotyping are a plus. The ideal candidate will have excellent problem-solving skills and familiarity with statistical analysis. This position reports to a PhD Scientist. The candidate will also culture motor neurons differentiated from induced pluripotent human stem cells and aid in the design and development of cellular assays to identify genes and compounds for treating neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). The candidate will have extensive experience with sterile in vitro laboratory tasks, including harvesting, storing, growing, and expanding neuronal cultures, formulating and adding compounds and molecular probes, measuring cell numbers with light microscopy and properties based on immunohistochemical markers, and writing SOPs and detailed records of all work.

Neurologist, Rehabilitation Service

As a neurologist on the Neurology and Rehabilitation Service at the Oklahoma City Veterans Affairs Health Care System,who subspecializes in rehabilitation. The duties of this position include: supervise residents and students and attend on the neurology inpatient service 2-3 months annually; attend on the rehabilitation inpatient service2-3 months annually; direct the power-mobility clinic; direct the spinal cord injury, spinal cord diseases, multiple sclerosis, and amyotrophic lateral sclerosis clinic; direct the stroke-care program. The applicant must be able toprovidecare and rehabilitation tothe following populations ofveterans: acute neurology patients in all outpatient and outpatient settings including intensive care units and emergency room; spinal cord injury, spinal cord disease, ALS and MS in the Hub and Spoke system of care; disabled patients due to neurological or orthopedic impairments for rehabilitation care on outpatient and inpatient settings. The applicant must be able to provide acute stroke and post-stroke care and supervise neurology stroke fellows who rotate at the VA. The applicant must participate in ongoing CARF accreditations activities for a Comprehensive Integrated Inpatient Rehabilitation Program, and assist in meeting standards forspecial accreditation in Stroke Rehabilitation. The applicant must be able to supervise neurology stroke fellows, neurology residents, other trainees and students who rotate on the Neurology Inpatient and Outpatient Service, and therefore must meet criteria for faculty appointment in Neurology at the University of Oklahoma Health Science Center.

PhD Position – Motor Neuron Disease

An exciting opportunity has arisen for a PhD project in the field of neuroimaging in motor neuron disease (MND). MND is a devastating, fatal, incurable neurodegenerative condition that typically results in death within 2-3 years. Therapeutic efforts have been limited by an incomplete understanding of disease pathophysiology, and because an available biomarker is lacking with which to track therapeutic effects over short timescales; for this reason, many potential agents never make it to clinical trial. There is increasing evidence for abnormal energy metabolism in MND, both a hypermetabolic early phase characterised clinically by weight loss and, later, mitochondrial failure, which may contribute to motor neuronal cell death.

Physician Scientist, Tenure-Track

The Center for Translational Medicine (CTM) at the Lewis Katz School of Medicine at Temple University is seeking qualified candidates and candidate nominations for a Tenure Track Faculty Physician-Scientist dedicated to neurodegeneration research. This position will also have clinical responsibilities and a joint appointment in the Department of Neurology.

Physician-Scientist (Faculty)

We seek Physician-Scientists with a basic science or translational research focus in adult-onset neurodegenerative diseases including Alzheimer’s, Parkinson’s, ALS or dementia. This position will complement and synergize with ongoing basic, translational and clinical research programs in the CTM and across Temple’s Medical campus. The CTM has state-of-the-art facilities in a new open-concept research building completed in 2012. The Center currently has multi-disciplinary research interests in gene and stem cell therapy, cardiac and neuronal signaling, heart failure, Alzheimer’s disease and mitochondrial pathobiology with research cores supporting imaging, gene therapy/vectors, bioenergetics and surgery/physiology. Interested candidates should have an MD or MD/PhD degree, and a strong academic record. Academic appointment is available at all levels and competitive packages will be offered based on qualifications.

Physician-Scientist, Tenure-Track

The Center for Translational Medicine (CTM) at the Lewis Katz School of Medicine at Temple University is seeking qualified candidates and candidate nominations for a Tenure Track Faculty Physician-Scientist dedicated to neurodegeneration research. This position will also have clinical responsibilities and a joint appointment in the Department of Neurology.

Post-Doctoral Fellow Research, RIC Sensory Motor Performance Program

General Summary: The Single Motor Unit Laboratory (SMPP) strives to understand how the nervous system controls individual motor units within a muscle so as to enable the generation of muscle force. Seeks to investigate the role of intrinsic properties of motoneurons that innervate relevant muscle fiber populations in providing such control under normal conditions and following such illnesses as stroke, spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS).

Postdoctoral Fellow

Sanofi’s Neuroscience Research Therapeutic Area based in Framingham, MA is looking for a highly qualified and motivated Postdoctoral Scientist to investigate the underlying disease biology of amyotrophic lateral sclerosis (ALS). The successful candidate will implement manifold in vitro and in vivo experimental approaches to help identify and validate innovative therapeutic targets for the treatment of ALS. These techniques include molecular biology, biochemistry, cell culture, immunoblotting, immunohistochemistry, microscopy, laser capture microdissection and the use of transgenic mouse models.

Postdoctoral Fellow

The lab for microRNA Models of Neurodegenerative Disease at the Institute of Molecular and Cell Biology is seeking to recruit a highly motivated Research Fellow to investigate pathogenic pathways underlying neurodegeneration linked to loss of microRNA function.

Postdoctoral Fellow, Cai Lab

The Department of Cell Biology and Neuroscience at Rutgers University is currently accepting applications for a postdoctoral position to study (1) the cellular mechanisms regulating autophagy-lysosomal function; (2) how altered axonal transport impacts the autophagy-lysosomal system, leading to axonal degeneration; (3) how deficits in the endolysosomal pathway contribute to the dysregulation of neuronal signaling. Given that defective axonal transport has been implicated in the pathogenesis of major neurodegenerative diseases, our studies will yield fundamental information to advance our understanding of human neurodegenerative diseases. Candidates for this position should hold a PhD with a strong research background in neurobiology or cell biology, at least in one of these areas: membrane trafficking, organelle transport, mitochondrial quality control, neuronal signaling, and neurodegenerative mouse models. Interested individuals should send CV, a personal statement describing research interests, and names and details of 3 references to cai@biology.rutgers.edu. Att: Qian Cai, M.D., Ph.D. Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Nelson Biological Laboratories, Busch Campus, 604 Allison Road, Piscataway, NJ 08854. Lab Webpage: https://cbn.rutgers.edu/cb-profile/userprofile/qc29 Application review will begin immediately and will continue until a suitable candidate is selected.

Postdoctoral Fellow, De Paola Lab

A Postdoctoral Research Fellowship is available in the Laboratory of Synaptic plasticity and Repair of Imperial College London, starting immediately. The aim of this project is to gain new and fundamental insights into the cellular and molecular mechanisms that regulate the regeneration of adult neocortical circuits. We have previously demonstrated that certain populations of cortical neurons exhibit enhanced spontaneous regenerative capacity compared to others, and we are now interested in understanding the mechanisms responsible for this differential response to injury. Our goal is to develop effective strategies to enhance functional axon and synaptic regeneration (Holtmaat et al Nature protocols 2009; Canty et al Nature Communications 2013; Grillo et al Nature Neuroscience 2015).

Postdoctoral Fellow, Farese-Walther Lab

We have a postdoctoral position available in the laboratory of HHMI Investigator, Tobias Walther, Ph.D., and Robert V. Farese, Jr, M.D., who jointly run a highly collaborative group at the Harvard School of Public Health. The lab is located in the Boston Longwood medical campus and is affiliated with the Department of Genetics and Complex Disease (HSPH), the Department of Cell Biology (Harvard Medical School), the Broad Institute of MIT and Harvard, and the Howard Hughes Medical Institute.

Postdoctoral Fellow, Neurobiology of Aging and Neurodegenerative Disease

The collaborative and interactive Arizona postdoctoral fellowship program in Neurobiology of Aging and Neurodegenerative Disease is seeking highly qualified applicants for positions supported by a National Institutes of Health training grant.  Institutions included in the research consortium include the University of Arizona, Arizona State University, Barrow Neurological Institute, The Translational Genomics Research Institute, Banner Alzheimer’s Institute, Banner Sun Health Research Institute, and Mayo Clinic.  All institutions are participants in the state wide Arizona Alzheimer’s Consortium.  Training programs afford the opportunity to study neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis, Traumatic Brain Injury, other related disorders, as well as non-pathological brain aging. Areas of interest include behavioral, systems and clinical neurosciences, molecular neurobiology and epigenetics, brain imaging, genomics, computational and statistical analysis of complex data sets, experimental therapeutics, and clinical neuropathological research.  Research resources include human longitudinal cohorts and data sets, a brain and body research donation program, PET and MRI research programs, wild type and transgenic rodent, non-human primate and human behavioral testing facilities, and cutting-edge cellular and molecular biological research methods with emphasis within each of the noted disciplines.  Trainees will benefit from a Professional Development Committee to foster career development from an omnibus perspective, and the training experience will be enriched via opportunities to work, learn, and produce across institutions, driven by a collaborative experimental training plan.  This is a U.S. Government funded training grant and is only available to U.S. citizens or Permanent Residents.  All institutions involved in this training program value our inclusive climate because we know that diversity in experiences and perspectives is vital to advancing innovation, critical thinking, solving complex problems, and creating an inclusive academic community.  Because, we seek a workforce with a wide range of perspectives and experiences, we encourage diverse candidates to apply, including people of color, women, veterans, and individuals with disabilities.

Postdoctoral Fellow, Neurogenetics

As postdoc you will be working on data from Project MinE (www.projectmine.com). This is unique genomic dataset in the field of Amyotrophic Lateral Sclerosis (ALS), a rapidly progressive, invariably fatal neurological disease that attacks the nerve cells responsible for controlling voluntary muscles, which include epigenetic, whole genome sequencing and clinical data of several thousand of ALS patients and matched controls. We have recently published the first results of this dataset (Van Rheenen et al. Nat Genet. 2016 (PMID: 27455348), and Kenna et al. Nat. Genet. 2016 (PMID: 27455347)). Your focus will be on exploring adding external controls and cases to this dataset while preserving type I error in case-control comparisons, annotating the non-coding genome by integrating our data with other publicly available omics datalayers, including RNAseq, Hi-C and Chip-seq and relating this to case-control status. Another type of genomic variation potentially related to ALS we are interested in, is structural variation. This means you need to have experience in working with raw sequencing data on a large number of samples and be able to apply complex genetic statistics in this context. There is a suitable ICT setup available for you to achieve this. We expect you to be able to use various bioinformatic tools on next-generation sequencing data and combine these to identify possible novel ALS risk genes, and pathological pathways. Also, we would like you to integrate these genetic data with drug databases in order to prioritize potential new drug targets for ALS and repurposing of existing drugs for ALS. This part of the work will be done in collaboration with a biotech company. You will also be expected to participate in writing scientific papers and grant applications, provide methodological advice to other members of the team (bioinformaticians, PhD students, postdocs, technicians), and participate in educating bachelor and master students.

Postdoctoral Fellow, Respiratory Physiology

Applications are being solicited for two NIH post-doctoral fellowships in respiratory neurobiology at the University of Wisconsin-Madison. The first position will investigate cellular mechanisms and physiological significance of neuroplasticity in the control of breathing, with an emphasis on sleep apnea. The second position will investigate functional outcomes of ex vivocell therapy (stem cell-based trophic factor delivery) to preserve respiratory motor neuron and diaphragm function in rodent models of Amyotrophic Lateral Sclerosis (ALS).

Postdoctoral Fellow, Sajjadi Lab

The Department of Neurology at the University of California, Irvine, invites applications for a post-doctoral fellow position in the laboratory of Dr. S. Ahmad Sajjadi MD, PhD beginning early 2017. The appointment is for 1 year with the possibility of extension upon satisfactory performance. We are seeking a highly motivated investigator with previous experience in neuropsychological assessments. Priority will be given to candidates with a recent PhD in neuroscience, psychology, or related fields and strong organizational and communication skills. The main purpose of this appointment is to establish a cohort of atypical dementia syndromes (mainly frontotemporal dementia) at the University of California, Irvine who will undergo regular clinical and neuropsychological assessments. Assessment of language and spontaneous speech will be a focus of the research and therefore, background in disorder of language will be desirable as is previous experience in neuro-imaging acquisition/analysis since the project will include structural MRI and PET scans. The position requires an individual who is an effective team player, highly organized, and innovative.

Postdoctoral Fellow, Sareen Lab

Dr, Dhruv Sareen’s independent research laboratory at the Cedars-Sinai Medical Center, Regenerative Medicine Institute focuses on using human iPSC technology to understand the molecular mechanisms underlying neurodevelopmental/degenerative diseases and how obesity is linked to the brain. His laboratory is particularly interested ‘disease-in-a-dish’ modeling for neuromuscular, neurodegenrative and motor neuron diseases including, amyotrophic lateral sclerosis (ALS). They are particularly interested in C9orF72 and other genetic forms of ALS and what are the common elements with sporadic forms of ALS. Using the iPSC platform his lab has developed novel methods for drug screening on patient motoneurons and dissecting mechanisms for motoneuron degeneration. In the context of stem cell modeling of neurodevelopmental (SMA) and neurodegenerative diseases (ALS) Dr. Sareen’s group is particularly interested in the mechanistic insights how specific neural cell types degenerate during the disease processes. They are using OMICS (proteome, transciptome, metabolome) and imaging methodologies to gain mechanistic insights into the mitochondrial and endorplasmic reticulum stress involvement. In addition, by understanding how the cells of the nervous system develop and differentiate we will be able to develop better and safer cells for transplantation and regenerative therapies. Dr. Sareen’s group has extensive experience in pluripotent and neural stem cell research. He has developed and directed a well-renowned human iPS cell core. He has published high-profile manuscripts on human iPSC-based disease modeling in SMA and ALS.

Postdoctoral Fellow, Van Damme Lab

The Laboratory of Neurobiology is part of the research group Experimental Neurology (Neuroscience Department) at KU Leuven. The group has a close collaboration with the Neurology Department of the University Hospitals Leuven with about 50 researchers in different domains.

Postdoctoral Fellow, Vande Velde Lab

Dr. Christine Vande Velde is looking to recruit a PostDoc to her laboratory located at the CRCHUM facility, a research center affiliated with the Université de Montréal and located in Downtown Montreal.

Postdoctoral Fellow, Xia Lab

A group of established investigators recently join the University of Central Florida (UCF) Medical College to form a competitive research team studying the mechanisms of neurodegeneration in amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). The team uses genetically engineered rats as a relevant model for the in vivo study of neurodegeneration associated with genetic mutations discovered by the team and by the other groups. Team members have documented findings in the journals including PLoS Genetics (2010 and 2011), the Journal of Clinical Investigation (2012), EMBO J (2013), PNAS (2013), and Acta Neuropath (2015). The team is funded by multiple NIH grants and has received supports from the UCF. The team invites experienced persons to join as a key member in the journey of discovery on disease mechanisms and therapies.

Postdoctoral Fellow, Xu Lab

A postdoctoral position is available in Zuoshang Xu’s laboratory to study mechanism of motor neuron degeneration in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease.

Postdoctoral Fellow, Yang Lab

The Yang lab also studies pathogenic roles of astrocyte dysfunction in neurological diseases/disorders, such as fragile x syndrome (FXS) and amyotrophic lateral sclerosis (ALS). The lab employs novel genetically modified mouse tools, in combination with primary astrocyte and neuronal cultures, imaging, electrophysiological and biochemical/molecular techniques. The candidate must be able to handle rodents and are familiar with biochemical techniques and prior knowledge of neurodegenerative diseases is desirable. It is expected that the candidate should have a recent PhD (less than 2 years) in Neuroscience/Genetics/Cell Biology/Biochemistry or equivalent and is able to communicate well with others. To apply, please send your CV (via e-mail) including all past education and training, a brief description of research interests, list of publications and other scientific activities as well as names and e-mail addresses of three references to Dr. Yongjie Yang at: Yongjie.yang@tufts.edu.

Postdoctoral Position

A postdoctoral position is available at Cornell University to study lysosomal dysfunction and neurodegeneration in ALS and FTLD. Highly motivated individuals with a strong background in cell biology or mouse genetics and an interest in neurodegenerative diseases are encouraged to apply. Please visit http://hu.wicmb.cornell.edu/ for more details and send your CV and 3 letters of references.

Postdoctoral Position

The Cedars-Sinai Regenerative Medicine Institute has a Research Postdoctoral position available to study the molecular mechanisms of neurodegeneration, with particular focus on axon degeneration in inherited peripheral nerve diseases, including demyelinating peripheral nerve disease. Candidate must be experienced with performing techniques ranging from neuronal and stem cell culture, molecular biology and bioinformatics (RNA-seq, exome seq), biochemistry and cell biology.

Postdoctoral Position

The Postdoctoral Scholar position in the laboratory of Steven Finkbeiner involves a collaboration between Verily Life Sciences and will focus on developing models and assays for investigating mechanisms of neurodegeneration. The ideal candidate will have experience in human iPSC culture and neuron differentiation, a strong molecular biology background and analytic skills with experience of imaging analysis software and statistical analysis programs.

Postdoctoral Position – Neurodegenerative Disease

The primary responsibility of the post-doctoral fellow will be to conceive, design, and analyze studies pertaining to the effect of neurodegenerative disease on structural (e.g., volumetric imaging and diffusion tensor imaging [DTI]) and functional (e.g., blood oxygen level dependent [BOLD] imaging and arterial spin labeling [ASL]) brain organization. Anticipated activities entail development and implementation of new analytic strategies to facilitate understanding of disease in the human brain, integration of large multi-modal imaging datasets, and analysis of the relationship between brain imaging markers and cognition or clinical status. Strong written communication skills are required. Attention to detail, organizational capability, and the ability to handle multiple concurrent tasks are essential. The post-doctoral fellow is expected to be able to work independently as well as part of a team in a fast paced environment.

Postdoctoral Position – Center fro Bionic Medicine

The Single Motor Unit Laboratory (SMPP) strives to understand how the nervous system controls individual motor units within a muscle so as to enable the generation of muscle force. Seeks to investigate the role of intrinsic properties of motoneurons that innervate relevant muscle fiber populations in providing such control under normal conditions and following such illnesses as stroke, spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS). The PostDoc Fellow will be responsible for the design, execution and interpretation of experiments within a laboratory team environment and a larger laboratory research program of engineers, physical therapists and neuroscientists focused on sensory motor performance and rehabilitation within a major, nationally leading Academic Rehabilitation Hospital.

Postdoctoral Position – Fenghua Hu Lab

A postdoctoral position is available at Cornell University to study lysosomal dysfunction and neurodegeneration in ALS and FTLD. Highly motivated individuals with a strong background in cell biology or mouse genetics and an interest in neurodegenerative diseases are encouraged to apply.

Postdoctoral Position Sensory Motor Performance

The Single Motor Unit Laboratory (SMPP) at the Rehabilitation Institute of Chicago (RIC) seeks to investigate the role of intrinsic properties of motor neurons that innervate relevant muscle fiber populations in providing such control under normal conditions and following such illnesses as stroke, spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS). The PostDoc Fellow will be responsible for the design, execution and interpretation of experiments within a laboratory team environment and a larger laboratory research program of engineers, physical therapists and neuroscientists focused on sensory motor performance and rehabilitation within a major, nationally leading Academic Rehabilitation Hospital.

Postdoctoral Position in Neurodegeneration

The Cedars-Sinai Regenerative Medicine Institute has a Research Postdoctoral position available to study the molecular mechanisms of neurodegeneration, with particular focus on axon degeneration in inherited peripheral nerve diseases. The primary focus of the candidate will be working with patient derived iPS cell lines, genetically engineering them using CRISPR technology, molecular and genomic characterization including exome sequencing, and differentiating them into motor neurons and Schwann cells to investigate cell replacement therapies for patients.

Postdoctoral Position – Lewcock Lab

Joe Lewcock’s Lab at Denali Therapeutics is seeking to recruit Postdoctoral Scientists to interrogate the molecular and cellular pathways underlying neurodegenerative diseases, with the ultimate goal of identifying new drug targets. Candidates should have proficiency in a broad range of molecular genetic, biochemical, and cellular techniques including: molecular cloning, transfection, RNA interference, Western blotting, immunofluorescence and/or live imaging techniques, and quantitative image analysis.

Postdoctoral Position, College of Veterinary Medicine

A Post-Doctoral Research Associate position is available immediately to study the mechanisms underlying the abnormal amyloid beta-peptide formation and neuronal cells death observed in the central nervous system (CNS) of Alzheimer’s disease and amyotrophic lateral sclerosis (ALS) patients using both animal models and cultured cell systems.

Postdoctoral Position- Pandey Lab

A Postdoctoral Researcher position is available immediately at the Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, to study the molecular mechanisms of human neurodegenerative diseases such as ALS and polyglutamine expansion diseases. The candidate will work with mammalian neuronal culture and drosophila models of ALS and other related human neurodegenerative diseases.

Postdoctoral Positions – Institute for Genomic Medicine

Multiple postdoctoral positions in Precision Medicine in Columbia’s Institute for Genomic Medicine.

Postdoctoral Positions in Neurodegenerative Disease

Various postdoc opportunities in ALS, FTD, and neurodegeneration research are available through several labs at University of Florida’s Center for Translational Research in Neurodegenerative Disease, including:

Principal Investigator, Laboratory of Neuronal Cell Biology

As Principal Investigator for the Laboratory of Neuronal Cell Biology (LNCB), he or she will be:

Principal Research Associate, Neuroscience

We are seeking a motivated Principal Research Associate to join a team of neuroscientists dedicated to developing novel therapies for diseases of the nervous system. The primary responsibility of this individual will be to validate new therapeutic targets for the treatment of amyotrophic lateral sclerosis (ALS) and additional CNS indications under consideration. The successful candidate will have experience with a variety of in vivo and in vitro experimental techniques.

Project Manager of Therapeutics

California Institute for Regenerative Medicine (CIRM) is looking to hire a talented individual to join the Therapeutics Team as a Project Manager. The mission of the CIRM Therapeutics Team is to recruit and enable the development of innovative clinical stage regenerative medicine / cell therapy programs to address the unmet medical needs of patients. The Project Manager reports to the VP of Therapeutics and will coordinate operations of the Therapeutics Team in order to accomplish this mission. The Project Manager will manage the development and execution of project team strategy and will optimize the team’s effectiveness in achieving project objectives in alignment with the stated quarterly and annual goals of that team.

Research Assistant, Neurodegenerative Disease

As a research assistant, the successful candidate will work with protein analysis (Western blot), histological analysis (immunofluorescence, in situ hybridization), analysis of data from in vivo neurotransmitter recordings (glutamate, dopamine recordings) and cytological analysis (immunofluorescence). The source of these samples will be from cell lines, animal models and human samples. The applicant will work close with patients and perform skin biopsies, blood sampling and lumbar punctures to obtain working material. The applicant will be responsible for analyzing these samples according to their respective protocols and the analyses are documented and stored in structured and easy to follow way.

Research Associate

Nuredis, Inc. discovers and develops small molecule therapies for a group of inherited neurodegenerative and neuromuscular diseases, aiming to treat the cause of disease rather than just managing symptoms. Nuredis was founded in 2016 based on technology licensed from Stanford, with facilities in Menlo Park. We are currently seeking self-driven, intelligent individuals to add their complementary talents to our highly-motivated team.

Research Associate

The position is for a full time Staff Research Associate to assist the PI in neuropathology research that investigates the pathogenesis of Alzheimer’s disease, frontotemporal dementia, and related disorders at UCSF Mission bay campus. The Staff Research Associate is expected to be open to learning new methods. One year of relevant laboratory experience including laboratory histology (embedding, cutting, immunohistochemistry, and coverslipping).The position represents an excellent opportunity to further basic laboratory and research skills in a dynamic clinical neuroscience environment. The successful individual will be an energetic, team player, self-directed learner with a keen interest in research.

Research Associate

Under the supervision of the Principal Investigator, the Staff Research Associate II (SRA II) will assist in the performance of behavioral testing and in the analysis of behavioral and neuroimaging data to support research on the neural bases of decision-making in healthy individuals with a family history of frontotemporal dementia. Specific techniques utilized in these studies will include online computer-based testing, task-based functional MRI, psychophysiology, voxel-based morphometry, functional connectivity, and computational modeling of behavior.

Research Associate – Taylor Lab

The Howard Hughes Medical Institute is seeking a highly motivated Research Specialist to join Dr. J. Paul Taylor’s group at St. Jude Children’s Research Hospital. The primary focus of this position will be the use of Drosophila melanogaster as a tool to investigate the molecular genetics of neurological diseases.

Research Associate II

Incumbent will assist with new metabolic targets to treat neurodegenerative disease. Under general supervision, assist the principal investigator and laboratory members in developing novel techniques and models to study the intersection between mitochondrial metabolism and neural physiology. Research duties will include assisting with animal handling, tissue harvest, dissections, and primary neural cell preparations. Additional responsibilities will include biochemical assays (immunoblot analysis ,subcellular fractionation), molecular biology (qRT-PCR and genetic manipulation of cells with siRNA, viral vectors, or CRISPR technology), and specialized metabolic assays (Seahorse XF analysis, plate-based enzymatic assays). Preparation of samples for high-content imaging or mass spectrometry analysis will also be required. Further duties will include general lab maintenance responsibilities, such as organization and management of supplies, chemical reagents, and animals.

Research Associate II/III

Summary

Research Associate, Baloh Lab

Under the direction of the PI or research staff, the Research Associate will help us achieve our research goals by performing and managing tissue culture projects in the lab. The primary focus will be human fibroblasts and stem cell culture, but primary neuron culture from animal models will also be performed.

Research Associate, Fraenkel Lab

The research group of Professor Ernest Fraenkel seeks a talented scientist to participate in an unprecedented study of the neurodegenerative disease ALS. Working with researchers at clinical and academic institutions across the United States, we are gathering data on approximately 1,000 ALS patients and controls. Induced pluripotent stem cell (iPSC) lines are being derived from each individual and these are being used to generate motor neurons for a wide range of omic studies. Our collaboration seeks to identify different subtypes of the disease, identify correlations between molecular pathways and clinical symptoms, and propose therapeutic strategies.

Research Associate, Gao Lab

A Research Associate position in the laboratory of Dr. Fen-Biao Gao at the Department of Neurology is available to help study frontotemporal dementia using induced pluripotent stem cells (iPSCs). Candidates with substantial research experiences in molecular biology (such as western blot, cloning etc.) and cell biology (such as stem cell culture and differentiation, or mammalian cell cultures in general) are encouraged to apply. Candidates with PhD or MD degrees will be considered as well.

Research Associate, Proteomics

Job description

Research Associate, Thomsen Lab

Dr. Gretchen Thomsen’s Laboratory at the Cedars-Sinai Regenerative Medicine Institute is looking for personnel to join our dynamic group. The incumbent should have an interest in the basic science of stem cells and animal research. The laboratory technician will, under the direction of the PI and lab manager, assist in the conduct of research in amyotrophic lateral sclerosis (ALS) and traumatic brain injury (TBI).

Research Associate, ViTAL Consortium

The postholder will join the ViTAL consortium of researchers working on Amyotrophic Lateral Sclerosis (ALS), funded by the charity TARGET-ALS. They will identify toxic elements that are secreted through exosomes in ALS, and determine their role in ALS. (Fixed-term until 30 June 2018)

Research Coordinator – UCSF Memory and Aging Center

Under the supervision of a Clinical Research Supervisor or Principal Investigator (PI) at the UCSF Memory and Aging Center, the Research Coordinator will act as a study coordinator for clinical studies of normal aging, Alzheimer’s disease, Frontotemporal dementia and other forms of neurodegenerative disease, and may receive training and development to prepare and advance for journey-level work at the next level within the series.

Research Coordinator, Senior

We are seeking a coordinator for a multi-site consortium using a novel approach to neuroimaging of neurodegenerative diseases. The lead site is Penn, and participating sites include Mayo Clinic, UCSF, MGH and Northwestern. All sites have specialized neuroimaging equipment, and we will be using advanced neuroimaging tools developed locally and in collaboration with the Human Connnectome Project (HCP) to analyze the acquired data. The successful candidate also will be responsible for managing the Penn site.

Research Programs Specialist

The Research Programs Specialist at the Weston Brain Institute will be responsible for developing the initiative’s scientific knowledge, running granting programs, and managing a portion of the Institute’s grant portfolio.  Candidate should have research experience in one or more neurodegenerative diseases of aging, including ALS and FTD with a relevant PhD or MD. This position is located in London, UK and reports into the global operations in Toronto, Canada.

Research Scientist

AC Immune is seeking a highly qualified Research Scientist to expand the

Research Scientist

The Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco (UCSF) is seeking a molecular/cell biologist to design, develop and validate novel tools for the study of neurodegenerative diseases. The director of the IND is Nobel Laureate Dr. Stanley Prusiner.

Research Scientist

The researcher will be devoted to the development of advanced techniques of in vivo Clinical Biochemistry, in particular metabolic (MR spectroscopy), microstructural and molecular (diffusion tensor imaging) and functional (fMRI) imaging, for the study of the central nervous system and neuromuscular system. The research activity will be applied to inflammatory, neurometabolic, neurodegenerative and neoplastic disorders, aimed to a) the identification of early diagnostic and prognostic markers and surrogate markers of treatment; b) the characterization of brain activations patterns; c) optimization of structural and functional connectivity analysis.

Research Scientist

Under general direction of the Principal Investigator (PI), leadership investigators, and project manager, the incumbent will undertake project activities under a CIRM award developing an embryonic stem cell-based therapy to treat Amyotrophic Lateral Sclerosis (ALS), making innovative and significant independent contributions pertaining to achievement of project milestones.

Research Scientist

We are looking for an experienced BS or MS degreed research scientist to join the Neuroscience department. The candidate will play a hands-on role in a highly collaborative team responsible for research on neurodegenerative diseases. You will conceive, conduct, and analyze experiments to identify and evaluate compounds or biologics in various assays and cellular models. These include but are not limited to bioanalytical and biochemical assays, human ES/iPS derived neuronal models, and analysis of tissue samples.

Research Scientist in Autoradiography

AC Immune is seeking a highly qualified Research Scientist. The candidate must possess scientific background in structural biophysics and protein dynamics in neurodegenerative diseases and a clear record of accomplishment in an academic or a commercial setting. S/he will work on the discovery and characterization of PET radiotracers for the diagnosis of neurodegenerative disorders. Previous experience in neuroscience and neurodegenerative disorders, notably ALS and FTD along with TDP-43, is an advantage. S/he must have demonstrated their ability to make significant discoveries in an academic setting or bring a research product to a clinical stage.

Research Scientist, Neuroinflammation

The Krembil Research Institute at the University Health Network in Toronto Canada is seeking an early to mid career basic scientist in the area of neuroinflammation. Preference will be given to individuals with a research focus on the involvement of innate immunity, including the roles of immune mediators such as microglia and astrocytes, and their expressed cytokines and chemokines, in neurodegenerative diseases affecting the human CNS. The successful candidate will have a PhD or MD/PhD, postdoctoral experience and demonstrated research excellence. The successful candidate will be expected to qualify for an appointment at the Assistant or Associate Professor level (status only) in the appropriate department at the University of Toronto.

Research Specialist

A full-time position is available in the laboratory of Dr. Corey McMillan in the Department of Neurology at the University of Pennsylvania. This laboratory focuses on translational neuroscience questions related to improving the diagnostic and prognostic biomarkers of related neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). We also explore genotype and phenotype relationships using a multimodal approach that integrates clinical, imaging, genetic, and biofluid datasets. Applicant responsibilities will include collection of psychometric and imaging data from patients with ALS and/or FTD, preliminary statistical analyses, database management, processing biofluid samples, and administrative coordination with consortia collaborators.

Research Specialist – Taylor Lab

The Howard Hughes Medical Institute is seeking a highly motivated Research Specialist to join Dr. J. Paul Taylor’s group at St. Jude Children’s Research Hospital. The primary focus of this position will be the use of Drosophila melanogaster as a tool to investigate the molecular genetics of neurological diseases.

Research Specialist, Biochemistry and Neurobiology

Calico is inviting applications from biochemists/neurobiologists who are excited to work as part of a research team focused on identifying and targeting pathways involved in neurological diseases and aging. We are looking for a highly motivated and creative person who will focus on studying the underlying biology of protein aggregation and clearance in neurodegeneration and aging. This position will require independent work and the ability to develop and implement biochemical assays and cell-based assays in CNS cell types as well as deploy functional genomic platforms.

Research Specialist, Plotkin Lab

A full-time position is available in the lab of Alice Chen-Plotkin in the Department of Neurology at the University of Pennsylvania. Our lab researches neurodegenerative disease, with a particular focus on frontotemporal dementia and Parkinson’s disease. Projects range from studying the basic mechanisms of disease to finding and developing clinically useful tools such as biomarkers. Responsibilities for this position will include assistance with biochemical, molecular biological, and cell biological assays as needed to meet scientific goals. In addition, familiarity with analysis of large genetic datasets is preferred, including knowledge of statistical and computational methods (i.e. familiarity with linear/logistic regression, ability to use R or other statistical tools). All members of the lab are also expected to attend weekly lab meetings and to participate in the educational activities (e.g. journal club) of the lab.

Research Study Coordinator

The Division of Neuromuscular Disorders is seeking a Research Support Coordinator to join a very active clinical research program with multiple ongoing research studies. The primary focus of the work will be on investigator-initiated research in the fields of amyotrophic lateral sclerosis (ALS) and myasthenia gravis (MG). The research support coordinator will work closely with clinical research coordinators, data manager, statistician, clinical staff and the Principal Investigator.

Research Technician

The laboratory is seeking a motivated individual to join our efforts in exploring disease mechanisms and developing therapeutic strategies for amyotrophic lateral sclerosis and dementia. Under the direction of the Principal Investigator, the research technician will perform laboratory experiments which include DNA and RNA purification, quantitative PCR, gel electrophoresis, Western blots, DNA cloning, immunostaining and preparation of libraries for high throughput sequencing. The incumbent will also be responsible for handling patient samples and genetic testing of neurodegenerative conditions as part of a research project in collaboration with the ALS multidisciplinary clinic. Additional skills include maintenance of cell cultures, ordering necessary reagents to conduct experiments, and participation in joint upkeep of the lab. Experience in mouse handling and surgical procedures is preferred. The candidate will participate to the research activity of the lab and is expected to be fully engaged in the scientific projects, as well as participate to the scientific lab meetings. The individual must pay attention to details, can work independently under minimal supervision, possess good verbal and written communication skills, and work well as part of a team.

Research Technician

We are looking for individuals interested in a career in medicine to join our productive clinical research team for a 1-year term limited position (possible extension 1-3 years depending on funding).

Research Technician, Biffi Lab

Our lab aims at developing and testing a novel pharmacological platform, based on MRI/PET traceable nanoparticles targeted to activated microglia, as a therapeutic approach to track and modulate neuroinflammation in Amyotrophic Lateral Sclerosis. This position will assist scientists in performing scientific research, development and/or clinical tasks of varying complexity. In general, this position will assist in the set up, operation and maintenance of laboratory instruments and equipment, monitoring experiments, making observations and calculating and recording results.

Science Officer

Prize4Life, a non-profit focused exclusively on accelerating the development of treatments for ALS, recipient of the 2011 Prime Minister Award for entrepreneurship and innovation, is looking for a Scientific Officer. We believe that biologists, chemists, engineers, clinicians, software developers and many others can all bring meaningful change to the field of ALS research, and victory over ALS can be, and should be, everyone’s.

Scientist

As Scientist and critical member of the committed Neuro-Immunology team, you’ll help Alector discover and develop novel drugs targeting dementia and other neurological disorders. You will design and prioritize your own experiments and research endeavors to further Alector’s collective scientific understanding. In doing so you’ll apply your scientific insights to grow the company and guide its direction. Your work will be both inside and outside of the lab, and both strategic and hands-on. As an early hire, you’ll be influential in championing and developing Alector’s culture.

Scientist – Neuroscience FDE

Lilly Neuroscience is seeking an associate-level scientist (Bachelors or Masters) to join the Neurodegeneration Team to facilitate its mission of discovering novel medicines for the treatment of Alzheimer’s disease, Parkinson’s disease, and other related neurodegenerative conditions. The individual must possess a keen interest to understand the pathophysiological processes that underlie neurodegenerative conditions such as Alzheimer disease and have an exceptional attention to scientific detail.

Scientist 1- CNS Discovery

The Discovery Research team has an opening for a neuropharmacologist at the Scientist 1 level. The qualified individual should have experience with the use and development of in vitro, ex vivo and in vivo approaches for CNS disorders including multiple sclerosis, neuroinflammation and neurodegeneration. Experience with iPSC models, primary cell screening concepts and/or drug repositioning will be an advantage.

Scientist I, ALS

Neurology Research at Biogen seeks a highly motivated and experienced associate scientist to join the new initiative on ALS (amyotrophic lateral sclerosis). The Neurology department is responsible for discovery research on pathogenic mechanisms of neurodegenerative disorders and translating these findings into novel strategies for therapeutic intervention. The successful candidate will execute in vivo experiments to support the validation of novel drug targets and the development of small- and large-molecule drugs for the treatment of ALS. A major component of this work will be the assessment of drug candidates in a multiple rodent models, using a wide variety of morphological and functional endpoints, working closely with members of the ALS team as well as multiple internal and external collaborators. You will work in a fast paced, highly collaborative team environment at an exciting period for ALS research.

Scientist I, Neuro Discovery, Research

We seek an independent neuroscientist focused on identification of new targets for promoting axon regeneration, axon integrity and synapsis. The candidate will (1) be expected with the goal of delivering new targets to the clinic, focusing on multiple sclerosis and other neurodegenerative diseases, (2) apply in vitro and in vivo models to study the underlying mechanisms of degeneration and dysfunction in neurodegenerative diseases, (3) be familiar with cellular and animal models to study the effects of small molecules, antisense oligonucleotides, and antibodies for their roles in regeneration and repair, (4) enjoy membership amongst a highly productive and dynamic research team with many possibilities to collaborate internally and with external academic leaders, and (5) be expected to lead the project, present and publish their findings.

Scientist I, Research

Perform Drosophila neurobiological research to study neuronal function including electrophysiology and imaging. Design and execute experiments that test disease biology and investigate neuronal function in genetic models of neurodegenerative disease in the fly. Conduct hands-on research and interact with other members of the Department of Neurology Research engaged in biomedical and behavioral studies. Perform research involving electrophysiological and imaging techniques in Drosophila.

Scientist I/II, NeuroImmunology

The Biogen Department of NeuroImmunology seeks a highly motivated and keen experimentalist whose primary responsibility is to advance drug discovery and development by performing bench research. The individual will be expected to design studies and execute research aimed at target discovery as well as the development of therapeutic approaches to treat acute neurological indications and chronic neurodegenerative diseases. The individual is expected to function independently and creatively within the context of project teams, drawing on pertinent literature, and to foster collaborations to maximize synergies and cross disciplinary approaches to advance the studies. The work will involve a wide array of in vitro and in vivo techniques and is expected to yield high quality publications.

Scientist I/II, Research

The Biogen Epigenetics group seeks a highly motivated, creative scientist who will expand capabilities in epigenomic engineering within our Epigenetics and Cell & Gene Therapy groups, in consultation with colleagues in Neurology and Rare Disease groups. This scientist will have interests in the discovery and validation of mechanisms, pathways and potential drug targets for the treatment of neurodegenerative and rare diseases. S/he will create the means for the validation and modulation of targets of interest through the development of epigenomic engineering approaches for the modulation of disease-relevant target genes.

Scientist I/II, Research

The Biogen Epigenetics group seeks a highly motivated, creative scientist who will expand capabilities in epigenomic engineering within our Epigenetics and Cell & Gene Therapy groups, in consultation with colleagues in Neurology and Rare Disease groups. This scientist will have interests in the discovery and validation of mechanisms, pathways and potential drug targets for the treatment of neurodegenerative and rare diseases. S/he will create the means for the validation and modulation of targets of interest through the development of epigenomic engineering approaches for the modulation of disease-relevant target genes.

Scientist I/II, Translational Sciences

The Biogen Department of Neuro/Immunology seeks a highly motivated and keen associate scientist whose primary responsibility is to advance target validation, drug discovery and development. The individual is expected to have mastered a broad range of experimental techniques, preferably having established expertise in the field of neuroimmunology. The individual will be expected to perform with significant independence with respect to designing and executing controlled experiments, analyzing and interpreting results, establishing and executing existing or new protocols/methodologies and recommending modifications. The individual is expected to read pertinent literature and exhibit knowledge of molecular and biological processes, applying their knowledge to propose new ideas and regularly make suggestions for creative solutions to technical challenges. The individual is expected to have strong written and verbal communication skills, preparing and delivering oral presentations, posters, draft research reports and contributing to manuscripts.

Scientist II, NeuroImmunology

The Neuroimmunology Research at Biogen is seeking a highly motivated scientist with a demonstrated track record of publications and presentations to drive independent basic exploratory research programs and lead cross-functional drug development team. The successful research scientist should possess a strong understanding of the mechanistic basis of neuroinflammation/neurodegeneration, as well as cutting edge knowledge on microglia and astrocyte biology, including familiarity with in vitro and in vivo models of neuroinflammation and neurodegenerative diseases. The scientist will be expected to apply a deep and broad knowledge of experimental neuroinflammation to creatively explore new biology and develop novel therapeutics. While prior drug development experience is preferred but not required, the candidate must have demonstrated the ability to work closely with research scientists in a team environment. Flawless oral and written communication skills are essential.

Scientist, Neurological Rare Disease

Sanofi’s Neuroscience Research Therapeutic Area based in Framingham, MA is looking for a highly qualified and motivated Scientist to develop therapies for rare neurologic and neurodegenerative diseases. This laboratory based position will include the opportunity to lead project teams and interact with internal and external functions to initiate new drug discovery programs and advance ongoing projects. The candidate will use epigenetics tools, genome editing technologies, –omics, bioinformatics and other approaches to identify and validate new targets. The candidate will also advance understanding of the role of the non-coding genome to identify and validate innovative and transformative therapies for rare neurologic diseases.

Scientist, Neuroscience

Genentech is inviting applications for a Scientist position (rank equivalent to assistant professor in academia) in the Department of Neuroscience. We are seeking an exceptional, highly motivated and creative scientist to lead innovative research efforts focused on unraveling the mechanisms of neurodevelopment and/or brain function in the context of nervous system diseases. He/she will also be expected to participate in inter-disciplinary teams to identify novel drug targets and discover new drugs to treat nervous system disorders. The ideal candidate will have significant experience in molecular and cellular biology using both in vitro and in vivo model systems, and possess a deep mechanistic understanding of the cellular pathways that contribute to diseases of the nervous system (e.g. neurodegenerative diseases). A solid track record of publications in top tier journals is required as is exceptional communication skills. The position will involve close collaboration with other research labs in Neuroscience as well as investigators in areas such as human genetics, bioinformatics, proteomics, imaging, and small molecule and large molecule drug discovery. The successful candidate will be expected to publish their research in high quality journals.

Senior Associate Scientist

Position Overview:

Senior Associate Scientist

We are seeking a Research Senior Associate Scientist to join a vibrant and growing group currently focusing on Neurodegenerative diseases within the Neuroscience Therapeutic Area, a key component of the Discovery Research unit at Amgen’s site in Cambridge, MA (Amgen MAssachusetts-AMA). The successful candidate must be highly motivated with a deep interest in developing new and effective therapeutics for Parkinson’s disease (PD)/ALS.

Senior Associate Scientist, ALS and PD

We are seeking a Research Senior Associate Scientist to join a vibrant and growing group currently focusing on Neurodegenerative diseases within the Neuroscience Therapeutic Area, a key component of the Discovery Research unit at Amgen’s site in Cambridge, MA (Amgen MAssachusetts-AMA). The successful candidate must be highly motivated with a deep interest in developing new and effective therapeutics for Parkinson’s disease (PD)/ALS.

Senior Associate Scientist, Neuroimmunology

The Neuroimmunology department at Biogen is searching for a committed, enthusiastic and dependable associate scientist to assist with the design, execution and interpretation of preclinical studies for drug discovery and development. The incumbent will be part of a multifunctional team with responsibility for target validation and evaluation of novel drug candidates for neurodegenerative/neuroinflammatory diseases. He/she should be able to plan and execute in vivo and in vitro experiments with high level of independency, organization and scientific rigor. He/she should be able to maintain an up-to-date knowledge of pertinent literature and possess excellent communication and interpersonal skills to efficiently present results to project team members.

Senior Manager/Associate Director Pharmacometrician

The Pharmacometrician is responsible for the construction, validation, and implementation of disease, placebo, exposure-response, and mechanistic PKPD models to evaluate risk/benefit and facilitate drug development decisions, in close collaboration with Clinical Pharmacologists and other R and D partners.

Senior Research Investigator

The Gene Therapy Program (GTP) and Orphan Disease Center (ODC) are entering a new era of unprecedented opportunity with great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases. Our R&D organization has a translational infrastructure that includes: technology discovery, specialized immunology assays operating under GLP, a Vector Core/Manufacturing unit that conducts GMP comparable work, and a large non-clinical program for animal testing under GLP including large NHP and rodent vivaria.

Senior Scientist, Neuroinflammation

The Merck Early Discovery Neuroscience team is seeking a highly motivated and technically skilled neuroscientist with a strong background in neuroimmunology to join our Boston-based early drug discovery team. Position is for a lab-based biologist who will generally be responsible for supporting the identification and validation of novel targets. The primary responsibilies will include the design and execution of both in vitro experiments and in vivo studies – applying biochemical, cellular/molecular, histological and imaging techniques – to drive toward a deeper understanding of disease pathogenesis, establish novel models thereof, and enable mechanism of action assessments for candidate therapeutics. The Senior Scientist will be an active participant in the critical scientific dialogue that supports our mission of early discovery in support of the Merck Neuroscience pipeline.

Senior Scientist, Neuroscience Research & Drug Discovery

Verge Genomics is seeking a highly motivated individual to spearhead pre-clinical development of disease modifying treatments for neurodegenerative diseases. You will be responsible for advancing our current and emerging lead candidate pipeline through all stages of pre-clinical development, acting as a leader of multidisciplinary project teams. You will oversee important external collaborations with contract research organizations (CROs), leading academic groups, non-profits, and pharmaceutical partners. As one of the first employees at Verge, you will develop help build the foundation of a revolutionary drug development model.

Sr. Clinical Scientist

The Sr. Clinical Scientist will work with the Medical Director functions of Early Clinical Development teams and provide scientific and clinical input into early stage clinical development programs. This role will work on cross-functional study teams for the design, execution, and monitoring of clinical trials, early clinical research studies, and/or external research projects, as well as assist with data interpretation and communication.. This individual will report directly into a Sr. Medical Director of Clinical Development or a Therapeutic Area VP and will interface directly with other functions including Clinical Development, Clinical Pharmacology, and Biomarkers.

Statistical Programmer

The Neuromuscular Program in the Department of Neurology at the University of Miami has an exciting opportunity for a full-time or part-time Statistical Programmer to join an active clinical and translational research group focused on therapy development for Lou Gehrig’s disease (Amyotrophic Lateral Sclerosis, or ALS). The statistical programmer will be an integral member of the research team and provide programming support for the cleaning, summarizing/reporting, and analysis of research data. The statistical programmer will work most closely with the biostatistician and the data manager. The appropriate title for the position will be contingent upon the selected candidate’s education and years of experience. Candidates with additional experience could be considered for a Sr. Statistical Programmer position.

Statistical Programmer, Neuromuscular Program

The Neuromuscular Program in the Department of Neurology at the University of Miami has an exciting opportunity for a full-time or part-time Statistical Programmer to join an active clinical and translational research group focused on therapy development for Lou Gehrig’s disease (Amyotrophic Lateral Sclerosis, or ALS). The statistical programmer will be an integral member of the research team and provide programming support for the cleaning, summarizing/reporting, and analysis of research data. The statistical programmer will work most closely with the biostatistician and the data manager. The appropriate title for the position will be contingent upon the selected candidate’s education and years of experience. Candidates with additional experience could be considered for a Sr. Statistical Programmer position. The primary responsibilities are: Develop and implement strategies for real-time data QC. Conduct routine data checks to ensure data integrity. Write SAS macros and programs for data cleaning, reporting (e.g. tables, listings, figures), and the creation of analysis datasets. Construct view tables from a MySQL database. Perform statistical analyses defined in statistical analysis plans, as needed. Perform other related duties and responsibilities, as assigned.

Technician B – Tom Maniatis Laboratory

The Maniatis lab is seeking a highly motivated Technician B to work on a project focusing on the progression of the neurodegenerative disease Amyotrophic Lateral Sclerosis (ALS). The technician will work closely with colleagues using techniques such as in vivo mouse genetics, gene expression profiling and in vitro cell culture assays. Comfortability with dissections preferred.

Translational Scientist

We sincerely invite applications from outstanding translational scientists who aim to conduct cutting-edge and innovative research. Successful applicants will be offered generous start-up packages and internationally competitive benefits. Positions will remain open until filled.

Director of Neurodegeneration Disease Models

Alector LLC (alector.com) is a privately-funded, broad-based, neuroscience biotech startup located in the San Francisco Mission Bay. We combine state-of-the-art antibody technology with recent discoveries in human genetics to discover and clinically develop a platform of novel disease modifying therapeutics for Alzheimer’s disease, Frontotemporal dementia, Parkinson’s disease, amyotrophic lateral sclerosis, and traumatic brain injury.

Director, Neuropharmacology

The Neuropharmacology Research group is seeking independent and motivated scientists to join a newly established research team focused on the rapid progression of novel therapeutics to humans for neurodegenerative, neurobehavioral and neuromuscular diseases. The Director, Neuropharmacology will be responsible for establishing and leading a research pharmacology group responsible for developing and leading innovative approaches to the treatment of neurodegenerative, neurobehavioral and neuromuscular disorders. The candidate will be expected to lead their own research project, as well as oversee other drug development programs with the goal of building a robust and sustainable portfolio of candidates for clinical development. The candidate will also oversee the efforts and be responsible for guiding the career development of 6-10 scientists.

Epidemiologist I

Serves as Registry Coordinator for the Massachusetts statewide registry of amyotrophic lateral sclerosis (ALS). Responsibilities include those related to the day-to-day operation of the Registry, including contact with all patient reporting sources to ensure complete case ascertainment, oversight of data abstraction and data verification activities, data entry of all clinical files received, and the management of all electronic and paper Registry files. This position is also responsible for maintaining a clean and accurate Registry database, conducting statistical analyses on program evaluation and ALS epidemiology in Massachusetts, assisting in the preparation of statistical reports, attending public meetings, and working with other technical staff on special studies. Other duties will include organizing annual advisory committee meetings and collaborating with other Bureau of Environmental Health (BEH) staff in the design and implementation of other environmentally-related chronic disease surveillance systems.

Faculty Position in Academic Faculty of Health Sciences

Curtin University is seeking to appoint an Associate Professor/Professor, to further strengthen Western Australia’s research on neurological disorders and neuroscience, at the soon to be completed Sarich Neuroscience Research Institute building.  You will take a leadership role in fostering translational research and links with industry and community groups.

Faculty Position in Computational & Systems Biology

The  Perelman School of Medicine at the University of Pennsylvania seeks candidates for an Assistant or Associate Professor position in the tenure track. The successful applicant will have experience in the field of Computational & Systems Biology with a focus on  neurodegenerative diseases, including modeling cellular and molecular interactions and pathways, use of model organisms for generating human disease oriented leads, analysis of large genomic and phenotype data sets, and personalized medicine for central nervous system disorders.

Faculty Position in Neuroinflammation and Neurodegeneration

The Department of Anatomy and Neurobiology at the University of Tennessee Health Science Center seeks an outstanding researcher in the area of neuroinflammation and neurodegeneration to fill an open rank tenure-track position. We seek candidates to complement and extend departmental and campus-wide research on the role of microglia/neuroinflammation in neurodegenerative diseases, especially, but not limited to, traumatic brain injury, chronic traumatic encephalopathy, stroke, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis.

Faculty Positions in Aging & Metabolism Research Program

The Oklahoma Medical Research Foundation (OMRF) is seeking established investigators to maintain a research program that addresses issues relevant to mechanisms of sarcopenia and frailty, neuromuscular junction maintenance, aspects of age-related changes in muscle physiology, or mechanisms of age-related neurodegeneration. Candidates with significant knowledge of diseases of neuromuscular degeneration, such as ALS, are of special interest.

Postdoctoral Position

The focus of the laboratory is to study gene therapy approaches for the treatment of neurodegenerative diseases such as lysosomal storage diseases (GM1-gangliosidosis and Tay-Sachs disease), amyotrophic lateral sclerosis (ALS), Huntington’s disease, and brain tumors. The position requires attention to detail, good communication, strong skills in experimental design and troubleshooting, an ability to work independently. The focus of this position is to investigate systemic AAV gene therapy approaches for Tay-Sachs disease using novel AAV capsids and vector designs.

Postdoctoral Position in Neurodegeneration Research and RNA Biology

Postdoctoral opportunities are available in Dr. Shuying Sun’s laboratory at Johns Hopkins University School of Medicine.  The Sun lab is interested in deciphering the RNA processing pathways altered by the ALS-causative mutants, identifying inhibitors of neuron toxic factors using various high-throughput screening platforms, and developing novelCRISPR technique-based therapeutic strategies.

Research Associate, Medicinal Chemistry

Cytokinetics is a late-stage biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators as potential treatments for debilitating diseases in which muscle performance is compromised and/or deteriorating. With an unmatched understanding of muscle biology and mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to increase muscle function and contractility. Working collaboratively, Cytokinetics’ dedicated employees are focused on advancing novel mechanism therapeutics to dramatically improve the lives of patients. With purpose and passion, we have committed to make an important impact on serious medical illnesses.

Scientist, In Vivo Biologist CNS Discovery Research, Manager

Teva Pharmaceuticals has an opening for a Scientist 1 in vivo biologist.  The individual should have substantial experience with the use and development of in vivo rat and/or mouse models for CNS disorders including neurodegeneration, including rodent behavior, surgical approaches, and genetic and/or viral vector modeling approaches.  Knowledge of pharmacology and pharmacokinetics as they relate to CNS drug discovery is preferred.

Senior Clinical Trial Manager

We are currently seeking a Senior Clinical Trials Manager to join our Clinical Operations group to provide key clinical support for the management, operation, and execution of multiple clinical trials (including global international trials) for Cytokinetics clinical programs.

Senior Manager/Associate Director, Informatics

Cytokinetics is a late-stage biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators as potential treatments for debilitating diseases in which muscle performance is compromised and/or deteriorating. With an unmatched understanding of muscle biology and mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to increase muscle function and contractility. Working collaboratively, Cytokinetics’ dedicated employees are focused on advancing novel mechanism therapeutics to dramatically improve the lives of patients. With purpose and passion, we have committed to make an important impact on serious medical illnesses.

Sr. Research Associate/Scientist I, Discovery Biology

Cytokinetics is a late-stage biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators as potential treatments for debilitating diseases in which muscle performance is compromised and/or deteriorating.  We seek a highly motivated and experienced Senior Research Associate/ Scientist I to join our Discovery Biology group. This individual will play a key role in designing, optimizing, and implementing a wide-range of biochemical and cell-based assays, as well as in assessing biochemical and cellular activity of candidate compounds. As a member of a multidisciplinary team, you will work closely with team members to identify, characterize and advance compounds through research and preclinical development.

Assistant Professor, Neuropsychology

The Department of Neurology at the Perelman School of Medicine at the University of Pennsylvania seeks candidates for an Assistant Professor position in the non-tenure clinician-educator track. The successful applicant will have experience in the field of Neurology with a focus on Neuropsychology. Applicants must have a Ph.D. degree and have demonstrated excellent qualifications in clinical care and research. The successful applicant must have completed a two-year post-doctoral fellowship in clinical neuropsychology, and be board eligible or licensed to practice Neuropsychology.