Figure 3. Diffusion tensor imaging in the spinal cords of WT and cerebroside sulfotransferase knock-out (CST-KO) mice.
Image credit: Takano, et. al. 2012 under CC BY license

Job Opportunities

To submit any new job opportunities for this list, please email ALSjobs@prize4life.org. List the employer, location, closing date if applicable, and a link to more information. Jobs are removed after 3 months, unless requested otherwise.

This free job bulletin board aims to help scientists identify job opportunities in the field of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Positions described as broadly spanning neurodegenerative diseases (NDG) are noted as ‘NDG‘. The job listing includes research positions at all levels, as well as non-research positions for which a research background at the MS, PhD, or MD level is required.


Click the title of any table column to sort.

Academia

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Postdoctoral Fellow or Senior Research Scientist, Gao Lab

Postdoctoral Fellow or Senior Research Scientist, Gao Lab

(Click title to open job details in a new window.)
Description:

A position at the postdoctoral or Senior Research Scientist level is immediately available in the laboratory of Dr. Fen-Biao Gao at the University of Massachusetts Medical School to study molecular pathogenic mechanisms of fronototemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) (Lu et al., Mol. Cell 2013; Gascon et al., Nat. Med. 2014; Freibaum*, Lu* et al., Nature 2015; Tran et al., Neuron 2015; Lopez-Gonzalez et al., Neuron 2016). Candidates with strong research experience in mouse genetics and molecular and cellular biology are encouraged to apply. Interested please send CV to fen-biao.gao@umassmed.edu


Link: https://www.nature.com/naturejobs/science/jobs/634157-postdoctoral-fellow-or-senior-research-scientist-level
Employer: University of Massachusetts Medical School
Location: Worcester, MA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: January 12th, 2018
Applications close: March 13th, 2018
University of Massachusetts Medical SchoolWorcester, MAPhDALSJan 12, 2018
NEW! Postdoctoral Fellow, Sun Lab

Postdoctoral Fellow, Sun Lab

(Click title to open job details in a new window.)
Description:

Postdoctoral opportunities are available in Dr. Shuying Sun’s laboratory at Johns Hopkins University School of Medicine. The lab will explore the fascinating frontiers of RNA metabolism dysfunction and RNA-targeting therapy in neurodegenerative diseases by combining molecular and cellular approaches, genome editing, proteomic, genomic and screening platforms.


The nervous system has extremely complex RNA processing regulation and dysfunction of RNA metabolism has emerged to play crucial roles in multiple neurological diseases. Mutations and pathologies of several RNA-binding proteins are found to be associated with neurodegeneration in both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). An alternative RNA-mediated toxicity arises from microsatellite repeat instability in the human genome. The expanded repeat-containing RNAs could potentially induce neuron toxicity by disrupting protein and RNA homeostasis through various mechanisms.


The Sun lab is interested in deciphering the molecular mechanisms of disease pathogenesis and seeks to translate the mechanistic findings to therapeutic target development to advance treatment options against neurodegenerative diseases. We are looking for highly motivated postdoc fellows with solid PhD training in biochemistry, molecular and cellular biology. Experiences with RNA biology, neuroscience or bioinformatics are preferred but not limited to. You will join a strong and highly interactive science community at Johns Hopkins.


Interested candidates should provide a cover letter (with statement of research interest and career goals), CV and the contact information for three references to Dr. Shuying Sun at shuying.sun@jhmi.edu. Please visit our lab website at http://labs.pathology.jhu.edu/sun/ for additional information.


Employer: Johns Hopkins University School of Medicine
Location: Baltimore, MD
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: January 11th, 2018
Johns Hopkins University School of MedicineBaltimore, MDPhDALS, FTDJan 11, 2018
NEW! Graduate Studentship

Graduate Studentship

(Click title to open job details in a new window.)
Description:

We are looking for highly motivated candidates to explore the role of C9ORF72 in neurodegeneration associated with amyotrophic lateral sclerosis (ALS). ALS is a motor neuron disease characterised by progressive injury and death motor neurons in the brain and spinal cord. Recent reports suggest that C9ORF72 hexanucleotide intronic repeat expansion cause ALS with high prevalence in both familial and sporadic cases. The C9ORF72 gene is located on chromosome 9p (9p21) and encodes twelve exons, with three transcription variants, and two possible protein isoforms, termed a and b. The normal expansion typically comprises a fewer than 30 of GGGGCC repeats. Pathogenic expansions consists of hundreds to thousands repeats. RNA foci are observed in fibroblasts and CNS of patients with C9ORF72 expansion, suggesting defects of RNA metabolism. Despite the significant progress in C9orf72 research, the exact function of the C9orf72 protein remains unclear. Thus, further research efforts aimed at better understanding the role of C9ORF72 protein are of the utmost importance to enable therapeutic development for ALS.


The successful candidate will join a team of several postdocs and technicians and he/she will benefit from their support and expertise. The student will use/learn cell culture, basic molecular biology techniques, CRISPR/Cas9 approach, iPS -derived from ALS patients, viral vector design/production and in vivo work. Gene manipulation in the cell culture model will be made using viral vectors and CRISPR Cas9 to modulate C9ORF72 gene. The student will attend several courses/workshops including Home Office course for in vivo experimentation. We support our PhD students to attend and present their research findings at national and international conferences.


The proposed work will be undertaken within the Sheffield Institute for Translational Neuroscience (SITraN: http://www.sitran.org/people), a world class environment for translational research. SITraN was specifically designed to bring together a multidisciplinary team of scientists, bioinformaticians and clinicians in order to effectively translate basic science discoveries into potential neuroprotective therapies for patients with MNDs. SITraN hosts state-of-the-art laboratories and equipment with a collaborative, multi-disciplinary environment including expertise in basic neuroscience, gene therapy, clinical neurology, neuropathology, computational biology, high throughput genomics and clinical trials methodology. The dedicated research accommodation encompasses tissue culture and gene therapy suites, facilities for live cellular imaging, confocal microscopy, laser capture microdissection, next generation sequencing, gene expression arrays and small molecule drug screening. We have an inter-faculty computational biology team embedded within SITraN that integrates and analyses our high dimensional data to iteratively develop systems models of disease.


The assembled team of supervisors has significant track record in studying the biochemistry of neurological disorders, vector design and evaluation in pre-clinical studies using in vivo models of neurodegeneration. This is reflected in high impact publications in prestigious journals such as Nature, Nature Medicine and Science Translational Medicine, PNAS. For further info about the project please contact Prof Mimoun Azzouz (m.azzouz@sheffield.ac.uk) and Dr Guillaume Hautbergue (g.hautbergue@sheffield.ac.uk).


Interested candidates should in the first instance contact:

Prof Mimoun Azzouz (m.azzouz@sheffield.ac.uk) and Dr Guillaume Hautbergue (g.hautbergue@sheffield.ac.uk).


To apply, please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply Please clearly state the prospective main supervisor in the respective box and select neuroscience as the department.


Link: http://www.shef.ac.uk/postgraduate/research/apply
Employer: University of Sheffield
Location: Sheffield, England
Sector: Academia
Degree required: BS
Conditions: ALS
Job posted: January 8th, 2018
University of SheffieldSheffield, EnglandBSALSJan 08, 2018
NEW! Postdoctoral Fellow, Plowman Lab

Postdoctoral Fellow, Plowman Lab

(Click title to open job details in a new window.)
Description:

The Department of Speech, Language, and Hearing Sciences at the University of Florida has a funded post-doctoral associate position available to work in the Swallowing Systems Core under the direct mentorship of Dr. Emily Plowman. This line is funded by an R01 grant from the National Institute of Neurological Disorders and Stroke (N.I.N.D.S) in the area of bulbar dysfunction in individuals with Amyotrophic Lateral Sclerosis. The successful post-doctoral associate would have the opportunity to work in the Swallowing Systems Core (SSC) that combines the expertise of both Dr. Plowman and Dr. Ianessa Humbert. The Swallowing Systems Core (SSC) is housed within the Dental Tower of Shands Hospital in the University of Florida Health Science Center and is equipped with its own research dedicated C-arm to perform high-resolution videofluoroscopy, fiberoptic endoscopic evaluation of swallowing workstation and high resolution manometry set up. The SSC currently comprises two Co-directors (Plowman and Humbert), two full time clinical coordinators, a biomedical engineer, four doctoral students, seven masters’ thesis students and five undergraduate honors students. The successful applicant would be expected to work cohesively with the entire SSC team.


Further, the post-doc associate will work collaboratively with the SSC research team to collect and analyze data, build grant-writing skills, prepare manuscripts for publication, and participate at national and international scientific meetings. As one of the country’s leading research institutions, the University of Florida provides an exceptionally supportive environment for research and collaboration. University support includes integrated and state of the art computer technology, exceptional students and staff, and a network of world-renowned scientists.


Interested applicants should submit: (1) a cover letter, (2) curriculum vitae, (3) a 1-page personal statement including research goals and how prior training and interests prepare you for this position, and (4) at least three letters of reference with their online application. Materials may be addressed to Emily K. Plowman, Ph.D. Review of applications will begin immediately. The successful applicant could begin in February of 2018.


SALARY: $47,476 USD, commensurate with education, skills, and experience


Link: http://explore.jobs.ufl.edu/cw/en-us/job/505893/postdoctoral-associate
Employer: University of Florida
Location: Gainesville, FL
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: January 5th, 2018
University of FloridaGainesville, FLPhDALSJan 05, 2018
Scientific Director, Research Professor

Scientific Director, Research Professor

(Click title to open job details in a new window.)
Description:

VIB and UAntwerp are in search for a dynamic, internationally recognized leader in genetics and genomics to inspire and lead the VIB research centre at the University of Antwerp. The selected candidate will be appointed as scientific director at VIB and will have a research professor appointment (ZAPBOF) as (full) professor at the University of Antwerp.


The scientific director/research professor will provide vision and leadership to the research centre, with responsibility for: developing the scientific strategy of the research centre and its future mission

creating a stimulating environment and dialectic culture, which fosters talent and triggers excellence

organizing and managing the research centre in terms of science, tech transfer, logistics, finance and human talent. It is expected that the scientific director/research professor will maintain active interest in leading an independent research lab (for which significant long term support will be provided). The scientific director/research professor will be a member of the VIB management committee in which he/she has co-responsibility for the overall success of VIB.


Candidates who are interested in this position are asked to send a complete CV, publication list, vision text (max. 5000 words) and 3 letters of reference to marijke.lein@vib.be and vacatures@uantwerpen.be. Closing date for applications is 31 March 2018.


Link: https://vibvzw.jobsoid.com/j/11077/scientific-director-research-professor
Employer: VIB and University of Antwerp
Location: Antwerp, Belgium
Sector: Academia
Degree required: PhD
Conditions: FTD, NDG
Job posted: January 2nd, 2018
VIB and University of AntwerpAntwerp, BelgiumPhDFTD, NDGJan 02, 2018
Assistant Professor, Pharmacology and Chemical Biology

Assistant Professor, Pharmacology and Chemical Biology

(Click title to open job details in a new window.)
Description:

The Department of Pharmacology at the Emory University School of Medicine invites applications for tenure-eligible Assistant Professor positions. Applicants for other ranks will also be considered. Beginning immediately, we seek investigators who will develop independent and vigorous research programs in any area of pharmacology and chemical biology. Individuals with demonstrated research interests and accomplishments in chemical biology, molecular pharmacology, systems pharmacology, as well as innovative approaches for therapeutic discovery and disease biology are encouraged to apply.


The successful candidates will join a vibrant and collegial basic research department with extensive scientific connectivity with clinical departments and divisions across the campus, including the Winship Cancer Institute, Dept of Chemistry, Dept of Pediatrics, Dept of Medicine, Dept of Hematology and Medical Oncology, Dept of Neurology, Center for Neurodegenerative Diseases, and other research units of the School of Medicine.  New faculty will have immediate access to powerful research infrastructures and core facilities, including the well-recognized Emory Chemical Biology Discovery Center with state-of-the-art high-throughput screening capabilities as well as a top-ranked graduate training program in pharmacology. The Department of Pharmacology at Emory is experiencing another phase of growth with the strong commitment of the leadership of the Woodruff Health Science Center and the School of Medicine, who share a focused vision for therapeutic innovation and translational biology.


Candidates must have a Ph.D., M.D., or equivalent degree in a relevant field of study, postdoctoral experience, and a demonstrated record of research excellence. Applicants should submit (i) a cover letter, (ii) a curriculum vitae, (iii) a brief statement of past research accomplishments, future research interests and goals, and teaching interest (<3 pages), and (iv) names and contact information for three references, in one pdf file to the Emory Pharmacology Search Committee, c/o Tanisha Haynes (tdevorc@emory.edu). Applicants should also arrange for three letters of reference to be sent directly to the above e-mail address. Consideration of applications for interviews will begin by January 30, 2018.


Link: https://jobs.sciencecareers.org/job/474128/assistant-professor-positions-in-pharmacology-and-chemical-biology/?LinkSource=PremiumListing
Employer: Emory University School of Medicine
Location: Atlanta, GA
Sector: Academia
Degree required: PhD and/or MD
Conditions: NDG
Job posted: December 29th, 2017
Emory University School of MedicineAtlanta, GAPhD and/or MDNDGDec 29, 2017
Postdoctoral Fellow

Postdoctoral Fellow

(Click title to open job details in a new window.)
Description:

The successful candidate will participate in federal and private-funded projects aiming to understand the role and molecular mechanism of autophagy (an essential lysosomal degradation pathway) in the regulation of metabolism and animal behavior, using knockout, knockin and transgenic mice, cell biology, biochemistry, imaging and state-of-the-art behavioral techniques.


Link: https://main.hercjobs.org/jobs/10596373/post-doctoral-fellow
Employer: Northwestern University
Location: Evanston, IL
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: December 22nd, 2017
Northwestern UniversityEvanston, ILPhDNDGDec 22, 2017
Postdoctoral Fellow, Tompa Lab

Postdoctoral Fellow, Tompa Lab

(Click title to open job details in a new window.)
Description:

The laboratory of intrinsically disordered proteins (IDPs) is in the VIB Center for Structural Biology (http://www.vib.be/en/research/scientists/Pages/Peter-Tompa-Lab.aspx) in Brussels, situated on the campus of Vrije Universiteit Brussel (https://www.vub.ac.be/en/). In the focus of the research conducted in the lab is the structure-function relationship of IDPs, towards which we are using a great variety of molecular-biological, structural, biophysical and computational tools.


The lab seeks a highly motivated and independent postdoctoral researcher, to work on the involvement of a variety of IDPs, such as TDP43, FUS, hnRNPA2 and dipeptide repeats (DPRs), in liquid-liquid phase separation (LLPS) in amyotrophic lateral sclerosis (ALS). The project will focus on characterizing the in vitro and in vivo phase separation of wild-type and mutant proteins, and their further transition toward pathological aggregated states.


Motivated candidates should apply online, by sending a CV, letter of motivation and contact details of two referees. For further enquiries please contact Peter Tompa.


Link: https://www.nature.com/naturejobs/science/jobs/632959-postdoctoral-position-tompa-group
Employer: VIB
Location: Gent, Belgium
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: December 22nd, 2017
Applications close: February 20th, 2018
VIBGent, BelgiumPhDALSDec 22, 2017
Postdoctoral Fellow, Mueller Lab

Postdoctoral Fellow, Mueller Lab

(Click title to open job details in a new window.)
Description:

We seek a talented and motivated postdoc to join the laboratory of Dr Christian Mueller in the Horae Gene Therapy Center at the University of Massachusetts Medical School. Our dynamic and collaborative research environment at UMMS includes world renowned clinicians and scientists. Additionally, our location close to Boston supports many collaborations with academic and industrial research groups. Under the leadership of Dr GuangPing Gao, the UMMS GTC is one of the top US gene therapy centers, focusing its research efforts on rare diseases of the liver, CNS, and eye, with a state-of-the-art vector core that handles vector production for its researchers.


Open positions include:  CNS Lead. Responsible for advancing the lab’s preclinical programs for CNS diseases. Lead indications are SOD1, C9orf72-linked amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). Projects will include early stage research on genome editing for ALS, an IND-enabling study in non-human primates for a gene therapy candidate for ALS, and an IND-enabling study in non-human primates for a gene therapy candidate for HD.


Required Qualifications:

Applicants should have a PhD in biomedical sciences with a strong background in molecular biology and biochemistry, as well a track record in the field of ALS/CNS disorders (CNS Lead role) or liver diseases (Liver Lead role). Hands-on experience with relevant mouse models as well as excellent knowledge of CRISPR-based genome editing are required. Ability to work independently in a fast-paced research environment and multitask, be highly organized and adaptable are required. Strong writing, verbal and interpersonal skills are required.


Required skills:

• PhD degree in biomedical sciences

• track record in ALS/CNS disorders or liver diseases with at least two first author publications

• hands-on experience with genetic mouse models (CNS or liver)

• excellent knowledge of CRISPR-based gene editing

• excellent communication skills both oral and written are essential

Preferred skills

• hands-on experience with CRISPR-based gene editing

• experience in next generation sequencing and bioinformatics

• experience in tissue culture, cytokine multiplex assays and ELISA

Additional Information:

Our lab is multicultural and supports personal development and work-life balance. Attractive salary and benefits available based upon relative working experience.


For more information on the Mueller Lab for Gene Therapy we invite you to visit our website: www.umassmed.edu/muellerlab

Interested candidates please email CV to: Chris.Mueller@umassmed.edu


Link: https://www.nature.com/naturejobs/science/jobs/632685-post-doctoral-associate-gene-therapy-center-28102
Employer: University of Massachusetts Medical Center
Location: Worcester, MA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: December 21st, 2017
Applications close: February 19th, 2018
University of Massachusetts Medical CenterWorcester, MAPhDALSDec 21, 2017
Postdoctoral Fellow, Sareen Lab

Postdoctoral Fellow, Sareen Lab

(Click title to open job details in a new window.)
Description:

Dr. Dhruv Sareen’s independent research laboratory at the Cedars-Sinai Medical Center, Regenerative Medicine Institute focuses on using human iPSC technology to understand the molecular mechanisms underlying neurodevelopmental/degenerative diseases and how obesity is linked to the brain. His laboratory is particularly interested ‘disease-in-a-dish’ modeling for neuromuscular, neurodegenrative and motor neuron diseases including, amyotrophic lateral sclerosis (ALS). They are particularly interested in C9orF72 and other genetic forms of ALS and what are the common elements with sporadic forms of ALS. Using the iPSC platform his lab has developed novel methods for drug screening on patient motoneurons and dissecting mechanisms for motoneuron degeneration. In the context of stem cell modeling of neurodevelopmental (SMA) and neurodegenerative diseases (ALS) Dr. Sareen’s group is particularly interested in the mechanistic insights how specific neural cell types degenerate during the disease processes. They are using OMICS (proteome, transciptome, metabolome) and imaging methodologies to gain mechanistic insights into the mitochondrial and endorplasmic reticulum stress involvement. In addition, by understanding how the cells of the nervous system develop and differentiate we will be able to develop better and safer cells for transplantation and regenerative therapies. Dr. Sareen’s group has extensive experience in pluripotent and neural stem cell research. He has developed and directed a well-renowned human iPS cell core. He has published high-profile manuscripts on human iPSC-based disease modeling in SMA and ALS.


Dr. Sareen’s laboratory is searching for a highly-capable Post-doctoral Researcher to join his research group to investigate disease mechanisms in neurodegenerative diseases, especially motor neuron disorders. The incumbent should have experience in in neurobiology, biochemistry, molecular biology and stem cells, including analyzing their genetic and biochemical profiles by OMICS technologies. Bioinformatics (programming in R) knowledge is a plus. By using human iPS cell technology and differentiating into different brain cells as well as other tissues of the body we will investigate brain-linked disease mechanisms to develop assays in patient-derived enural cell types and screen for novel therapeutics. Working independently but in close cooperation and in consultation with the PI and other Research Scientists at RMI, the Post-doctoral Researcher will perform routine and complex laboratory procedures throughout. The Post-doctoral Researcher will be expected to assist the PI in preparation of multiple grant proposals and submission of such proposals. They will also prepare full manuscripts for publication as primary first and co-authors. The researcher will be expected to assist the PI in maintaining institutional IRB/SCRO protocols as well as develop new animal and IACUC protocols. The incumbent will develop, adapt, and implement new research techniques and protocols and will analyze and interpret data. They will participate in presentations as author or co-author on scientific meeting abstracts.


Under the direction of Dr. Sareen (PI) the incumbent will help us achieve our research goals by performing the principal duty of using pluripotent and neural stem cell culture techniques to generate neuronal and other tissue differentiation protocols, characterization of the differentiated cells (control vs disease) using techniques such as gene and protein expression, physiological, and phenotypic assessments. The candidate will also be expected to develop and perform differentiation protocols to direct pluripotent stem cells to endoderm, ectoderm and mesoderm lineages. The successful candidate will be responsible for all cell maintenance, expansion and genetic modification using viral vectors or other gene-editing methods. Therefore, experience in stem cell and neurobiology, knowledge of pluripotent/neural cell markers combined with a proven record in stem cell culture techniques is essential. Experience with bioinformatics analysis of RNA-seq and mass spec proteomics data are important.


Prior experience in novel genome-editing technologies (CRISPR/Cas9) using pluripotent stem cells is a great asset. Prior experience in high-content compound screening/imaging techniques, handling of the Molecular Devices Image Express Micro system, and a Mass Spectrometer with data analysis are preferred traits. Proficiency in computer algorithm development for automating image-based analysis is also a desirable trait.


Link: https://www.cedars-sinaimedicalcenter.apply2jobs.com/ProfExt/index.cfm?fuseaction=mExternal.showJob&RID=26507&CurrentPage=26
Employer: Cedars Sinai
Location: Los Angeles, CA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: December 20th, 2017
Cedars SinaiLos Angeles, CAPhDALSDec 20, 2017
Postdoctoral Fellow, Miller Lab

Postdoctoral Fellow, Miller Lab

(Click title to open job details in a new window.)
Description:

Applications are invited for a postdoctoral research associate in the Department of Basic and Clinical Neuroscience at the Institute of Psychiatry, Psychology and Neuroscience. The post is funded by Alzheimer’s Research UK. Signaling between the endoplasmic reticulum and mitochondria regulates many fundamental cellular functions. This signaling is facilitated by tethering proteins that facilitate recruitment of regions of ER to mitochondria; we have identified such tethers. Recent studies including work from our group have demonstrated that ER-mitochondria signaling is damaged in Alzheimer’s disease, Parkinson’s disease and related dementias. This project is to study further ER-mitochondria signaling and tethers in dementia. It also aims to determine the potential benefits of using pharmacologically active compounds to correct damaged ER-mitochondria signaling in models of frontotemporal dementia/motor neuron disease. These studies may reveal new strategies for treating dementia.


Experience in working with transgenic mouse models, advanced microscopy, biochemical, cell and molecular biology approaches including neurons would be advantageous. Knowledge of defective signaling processes in dementia and related disorders will also be useful. The successful applicant will join an established research group headed by Professor Chris Miller see www.kcl.ac.uk/ioppn/depts/bcn/Our-research/Neurodegeneration/miller-cell-biology-als/about-us.aspx


The salary will be paid at Grade 6, £33,518 – £37,706 per annum, plus £2,923 per annum London Allowance.


The selection process will include a presentation and a panel interview.


Interviews are scheduled to be held in January/February 2018.


For an informal discussion to find out more about the role please contact Professor Chris Miller at chris.miller@kcl.ac.uk


To apply for this role, please go to the King’s College London HireWire Job Board and register to download and submit the specified application form.


Link: http://www.jobs.ac.uk/job/BGN503/postdoctoral-research-associate/
Employer: King's College London
Location: London, England
Sector: Academia
Degree required: PhD
Conditions: ALS, NDG
Job posted: December 18th, 2017
Applications close: January 22nd, 2018
King's College LondonLondon, EnglandPhDALS, NDGDec 18, 2017
Chair, Neurodegenerative Disorders

Chair, Neurodegenerative Disorders

(Click title to open job details in a new window.)
Description:

The Kam Ling Barbara Lo Chair in Neurodegenerative Disorders will be situated at the Brain and Mind Centre of the University of Sydney, a pre-eminent multidisciplinary facility at the forefront of brain and mind sciences. The successful applicant will provide academic leadership in basic neuroscience with translational links to clinical neuroscience, particularly in neurodegenerative and dementia research. The successful candidate may bring particular experience in the realm of inflammation, genetics, animal or cellular models, particularly in relation to large-scale neurodegenerative and dementia-related research programs currently underway at the Brain and Mind Centre.


All applications must be submitted via the University of Sydney careers website. Visit sydney.edu.au/recruitment and search by reference number 1569/0817 (The Kam Ling Barbara Lo Chair in Neurodegenerative Disorders) for more information and to apply.


Employer: University of Sydney
Location: Sydney, Australia
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: December 11th, 2017
Applications close: January 31st, 2018
University of SydneySydney, AustraliaPhDNDGDec 11, 2017
Assistant or Associate Professor, Neuroscience

Assistant or Associate Professor, Neuroscience

(Click title to open job details in a new window.)
Description:

We are seeking individuals with research interests that complement our existing programs related to biological mechanisms and modeling of neurodegenerative diseases. Of particular interest are programs with a focus on Alzheimer’s Disease, Frontotemporal Dementia, and Parkinson’s Disease. Candidates with expertise and documented productivity in research areas that include investigation of how unfolded protein responses contribute to these diseases, with particular focus on tauopathies, are preferred. Candidates must have a desire to expand the educational landscape of the Department of Neuroscience through teaching and research training program development.


The successful candidate is expected to have a sustained track record for securing extramural funding and a strong publication record. Applicants will be expected to maintain strong research programs with evidence of continued extramural support and publications, and to demonstrate a commitment to excellence in teaching and mentoring graduate and medical students.


Applicants should submit a single PDF with curriculum vitae, a brief description of research interests, and names and contact information of three references.


Link: https://www.startwire.com/jobs/gainesville-fl/assistant-associate-professor-neuroscience-34659873
Employer: University of Florida
Location: Gainesville, Florida
Sector: Academia
Degree required: PhD
Conditions: FTD
Job posted: December 8th, 2017
University of FloridaGainesville, FloridaPhDFTDDec 08, 2017
Research Specialist, Southworth Lab

Research Specialist, Southworth Lab

(Click title to open job details in a new window.)
Description:

The Institute for Neurodegenerative Diseases (IND) at UCSF, Mission Bay Campus is seeking a Specialist for full-time work to perform and manage research activities in biochemistry and structural biology. The position is in the laboratory of Dr. Daniel Southworth and will support research efforts using cryo-electron microscopy to determine 3D structures of important biological macromolecules associated with human neurodegenerative diseases. Highly motivated candidates capable of independent problem solving and teamwork are encouraged to apply. This position will be part of a collaborative environment with access to state-of-the-art facilities in the Sandler Neurosciences Building on the UCSF Mission Bay campus. A successful candidate will be hired at the Junior, Assistant, or Associate Specialist rank commensurate with experience and qualifications.


Duties Include:

• Perform molecular cloning, protein expression, cell culture and protein purification experiments.

• Participate in lab meetings and multidisciplinary collaborations.

• Maintain chemical inventory and ensure lab compliance with health and safety.

• Perform general lab maintenance including ordering supplies and making cell culture media.

• Receive training and perform advanced research techniques including cryo-electron microscopy, computational biology, and protein biochemistry.


Required Qualifications:

• Specialists appointed at the Junior rank must possess a minimum of a Bachelor’s degree in biomedical sciences or related field.

• Specialists appointed at the Assistant or Associate rank must possess a minimum of a Master’s degree in biomedical sciences or related field.

• 1-2 years of biomedical research and/or lab management experience.

• Previous experience in biochemistry lab work .


Desired Qualifications:

• Experience in molecular biology including PCR, cloning, and work with recombinant DNA.

• Experience in biochemistry methods including protein expression and purification and work with baculovirus-insect cell expression systems.

• Experience in structural biology methods such as x-ray crystallography.


Appointees in the Specialist series will be expected to engage in specialized research, professional activities and do not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions, and may participate in University and Public Service.


Please apply online at: https://aprecruit.ucsf.edu/apply/JPF01716.


Link: https://aprecruit.ucsf.edu/apply/JPF01716
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: MS
Conditions: NDG
Job posted: December 8th, 2017
University of CaliforniaSan Francisco, CAMSNDGDec 08, 2017
Assistant or Associate Professor, Computational & Systems Biology

Assistant or Associate Professor, Computational & Systems Biology

(Click title to open job details in a new window.)
Description:

The Department of Pathology and Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania seeks candidates for an Assistant or Associate Professor position in the tenure track. The successful applicant will have experience in the field of systems biology emphasizing the central nervous system. Responsibilities include developing and carrying out an independent research program that is synergistic with the scientific missions of Penn Neurodegeneration Genomics Center, and participating in graduate and medical school education. Applicants must have an Ph.D. and/or M.D. degree and have demonstrated excellent qualifications in education and research.


The successful candidate should interface with the strong ongoing programs in the genetics and pathobiology of neurodegenerative diseases. We seek candidates who will develop cutting edge research that develops computational models, methodologies and/or experimental approaches to address biological and biomedical problems related to the brain with the eventual goal of developing therapeutic interventions for major neurodegenerative diseases. Potential research focus includes but is not limited to modeling cellular and molecular interactions and pathways, use of model organisms for generating human disease oriented leads, analysis of large genomic and phenotype data sets, and personalized medicine for central nervous system disorders. Experience in systems biology and human genetics is desirable. The Department of Pathology and Laboratory Medicine (http://pathology.med.upenn.edu/), the Penn Neurodegeneration Genomics Center (http://www.med.upenn.edu/pngc/), and the University of Pennsylvania (http://www.upenn.edu/) include faculty with diverse investigative interests with ample opportunities for collaborations.


Applicants should submit a cover letter, curriculum vitae, and a research statement. Review of applications will begin on immediately and will continue until the position is filled.


Apply for this position online at: https://www.med.upenn.edu/apps/faculty_ad/index.php/g/d4878


Link: https://www.med.upenn.edu/apps/faculty_ad/index.php/g/d4878
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: PhD and/or MD
Conditions: NDG
Job posted: December 7th, 2017
Applications close: February 5th, 2018
University of PennsylvaniaPhiladelphia, PAPhD and/or MDNDGDec 07, 2017
Assistant, Associate or Full Professor, Biomedical Sciences

Assistant, Associate or Full Professor, Biomedical Sciences

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Description:

The UTRGV School of Medicine is seeking Faculty members at the Assistant, Associate or Professor level experienced in research in Biomedical Sciences. The background should be in all disciplines of biomedical sciences including endocrine and metabolic diseases (such as diabetes and obesity), neuroscience and neurodegenerative diseases, cancer or oncology research and research in infectious diseases. The selected individuals will carry out high quality research projects and are expected to successfully acquire extramural research support. Laboratory space, competitive salary and start-up packages are available. Postdoctoral research experience in a top-rated research program is preferred.


Candidates must possess a terminal Degree of (Ph.D. or M.D.) or equivalent with post-doctoral experience in the area of expertise. Academic rank will be awarded commensurate with experience and academic credentials.


For consideration, please forward a copy of your CV, statement of interest, future research plan and three references.


Link: https://jobs.sciencecareers.org/job/472848/new-medical-school-seeks-biomedical-science-faculty/
Employer: University of Texas Rio Grande Valley School of Medicine
Location: Edinburg, Texas
Sector: Academia
Degree required: PhD or MD
Conditions: NDG
Job posted: December 5th, 2017
University of Texas Rio Grande Valley School of MedicineEdinburg, TexasPhD or MDNDGDec 05, 2017
Chief of Staff, VA

Chief of Staff, VA

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Description:

VA Puget Sound Health Care System (VAPSHCS), located in Seattle, Washington, and the University of Washington (UW) are recruiting for a Physician to serve as their Chief of Staff to provide administrative, programmatic, and clinical leadership for the medical center.


VAPSHCS provides health care annually to more than 100,000 Veterans in a large geographic area between two major divisions, Seattle and American Lake, as well as VA-staffed Community-Based Outpatient Clinics throughout Western Washington. The medical center has a strong affiliation with the University of Washington School of Medicine as well as a number of other educational institutions, and hosts hundreds of medical residents in 37 specialties, dental residents in three specialties, medical students, nursing-auxiliary students, and nursing-professional students. VAPSHCS has one of the most robust and competitive research programs in VA and is home to seven nationally recognized Centers of Excellence: Multiple Sclerosis Center of Excellence West (MSCoE West), Center of Excellence in Substance Abuse Treatment and Education (CESATE), Epilepsy Center of Excellence, Amyotrophic Lateral Sclerosis (ALS) Center of Excellence, Center of Excellence in Primary Care Education, RR&D Center of Excellence for Limb Loss Prevention and Prosthetic Engineering, and Center of Innovation for Veteran-Centered and Value-Driven Care.


The qualified applicant to the Chief of Staff position will be a physician (M.D. or foreign equivalent), who is board certified in any specialty recognized by the American Board of Medical Specialties (or foreign equivalent) and holds significant leadership, mentoring, and management experience in a tertiary care environment, plus strong health care operations and planning experience. S/he must have demonstrated expertise in the academic missions of education and research in an affiliated environment and would be appointed to the full-time faculty at the University of Washington at the Associate (Job Class Code 0112) or Full Professor (Job Class Code 0111) level, without tenure due to funding (WOT). These are 12-month, indefinite appointments. University of Washington faculty engage in teaching, research and service.


Other Requirements: US citizenship; current, full and unrestricted license to practice medicine in a state, territory, or commonwealth of the United States; fluency in spoken and written English.


Link: https://main.hercjobs.org/jobs/10523960/school-of-medicine-va-chief-of-staff-8211-associate-or-full-professor-wot-aa21613
Employer: University of Washington
Location: Seattle, WA
Sector: Academia
Degree required: MD
Conditions: NDG
Job posted: December 1st, 2017
University of WashingtonSeattle, WAMDNDGDec 01, 2017
Clinical Assistant Professor, Neuropsychology

Clinical Assistant Professor, Neuropsychology

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Description:

The Neuropsychology Section in the Department of Neurology at the Indiana University School of Medicine and Indiana University Health Physicians has an immediate opening for an Adult Neuropsychologist at the rank of Clinical Assistant Professor. The Section of Neuropsychology is situated in new space inside a unique, integrated clinical neuroscience center of excellence, comprising neurology, psychiatry, neurosurgery, and related services. Responsibilities will include coordination and provision of clinical assessment services, participation in multidisciplinary treatment teams, supervision of pre- and postdoctoral trainees and staff, and participation in the overall academic mission (including lectures to neurology residents). Major patient populations include neurodegenerative diseases, movement disorders, epilepsy, oncology, and brain injury, as well as a broad range of complex medical disorders. Although primarily a clinical position, there are significant opportunities for participation in research, including brain imaging work in alcoholism risk, Alzheimer disease, stroke, epilepsy, etc. Requirements include post-doctoral training in clinical neuropsychology and eligibility for licensure in Indiana. Preference will be given to ABPP-eligible or already board certified clinicians experienced with the above patient populations. Applications will be considered until the position is filled. Indiana University is an EEO/AA Employer, M/F/D. Qualified candidates should submit a letter of career goals and interests and a current CV to: http://indiana.peopleadmin.com/postings/5050


Link: http://indiana.peopleadmin.com/postings/5050
Employer: Indiana University
Location: Indianapolis, IN
Sector: Academia
Degree required: Board-certified neuropsychologist preferred.
Conditions: NDG
Job posted: December 1st, 2017
Indiana UniversityIndianapolis, INBoard-certified neuropsychologist preferred.NDGDec 01, 2017
Postdoctoral Fellow, Shirley Ryan AbilityLab

Postdoctoral Fellow, Shirley Ryan AbilityLab

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Description:

The Single Motor Unit Laboratory (SMPP) strives to understand how the nervous system controls individual motor units within a muscle so as to enable the generation of muscle force. Seeks to investigate the role of intrinsic properties of motoneurons that innervate relevant muscle fiber populations in providing such control under normal conditions and following such illnesses as stroke, spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS).


The PostDoc Fellow will be responsible for the design, execution and interpretation of experiments within a laboratory team environment and a larger laboratory research program of engineers, physical therapists and neuroscientists focused on sensory motor performance and rehabilitation within a major, nationally leading Academic Rehabilitation Hospital.


The PostDoc Fellow consistently demonstrates support of the SRAlab statement of Mission and Philosophy by striving for excellence, contributing to the team efforts and showing respect and compassion for patients and their families, fellow employees, and all others with whom there is contact at or in the interest of the institute.


The PostDoc Fellow demonstrates SRAlab Core Attributes: Communication, Accountability, Flexibility/Adaptability, Judgment/Problem Solving, Customer Service and SRAlab Values (Hope, Compassion, Discovery, Collaboration, & Commitment to Excellence) while fulfilling job duties.


Link: https://ricc-hr.silkroad.com/epostings/index.cfm?fuseaction=app.jobinfo&jobid=178712&company_id=16087&version=1&source=ONLINE&jobOwner=994841&aid=1
Employer: Shirley Ryan AbilityLab
Location: Chicago, IL
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: December 1st, 2017
Shirley Ryan AbilityLabChicago, ILPhDALSDec 01, 2017
Postdoctoral Fellow, Zhang Lab

Postdoctoral Fellow, Zhang Lab

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Description:

Two fully funded postdoctoral positions are immediately available, in the laboratory of Chun-Li Zhang, Ph.D., Department of Molecular Biology. One is to examine human neurodegenerative disease by using human embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and age-matched directly reprogrammed neurons. The focus is on molecular and cellular mechanisms underlying degeneration and the identification of chemical compounds promoting neuronal survival and function.


The second position is to examine neural reprogramming and regeneration after brain and spinal cord injury and degeneration. The focus is on reprogramming endogenous glial cells to functional neurons in the adult brain and spinal cord. Molecular mechanisms, neural circuitry, and behaviors will be examined.


The Zhang laboratory is well equipped for both in vitro and in vivo studies in modern neuroscience. The successful candidate will also benefit from exceptional core facilities and a very collaborative environment. UT Southwestern is the home of 6 Nobel Laureates, 22 members of the National Academy of Sciences, and 18 members of the National Academy of Medicine.


Self-motivated individuals with a Ph.D. degree and solid publication records are encouraged to apply. Candidates with experience in molecular and cellular neuroscience and electrophysiology are preferred.


Interested individuals should send a CV, statement of interests, and a list of three references to:


Chun-Li Zhang, Ph.D.W. Caruth, Jr. Scholar in Biomedical Research

Department of Molecular Biology, Center for Regenerative Science and Medicine

UT Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390-9148


E-mail: Chun-Li.Zhang@UTSouthwestern.edu


Link: http://neurojobs.sfn.org/jobs/10519749/postdoctoral-fellow-on-neurodegeneration-and-regeneration
Employer: University of Texas-Southwestern
Location: Dallas, TX
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: November 30th, 2017
University of Texas-SouthwesternDallas, TXPhDNDGNov 30, 2017
Postdoctoral Fellow, Knowles Lab

Postdoctoral Fellow, Knowles Lab

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Description:

Applications are invited for a Postdoctoral Research Associate (PDRA) to work on the development and applications of a microfluidic platform for analysing of Fused in Sarcoma (FUS) protein assembly, with a focus on liquid-liquid phase transitions using recombinant protein, cellular and cultured neuron systems, a project funded by the Wellcome Trust. The PDRA will work in the group of Professor Knowles in the Department of Chemistry.


The aim of this interdisciplinary project is to gain mechanistic insights into the aggregation of Fused in Sarcoma (FUS) proteins, known to be associated with two neurological pathologies, Amyotrophic lateral sclerosis (ALS) and Frontotemporal lobar degeneration (FTLD). In ALS, modification in FUS’ methylation prevents it from binding transportin and sequesters it in the cytoplasm, where it accumulates and aggregates to form cytoplasmic inclusion.


To understand the role of protein methylation on the aggregation and phase transition mechanism and the risk of malignant progression it is important to understand the physicochemical basis of this phenomena both in-vitro and using in-vivo cell culture models. To this end the PDRA will combine cell biology with microfluidic techniques to develop biophysical toolkit that allows real-time characterisation of FUS aggregation kinetics and apply these to experiments at single cell resolution.

Candidates should have (or be about to obtain) a PhD in chemistry, biophysics, soft materials science or a related discipline. Prior experience with microfluidics is an advantage but not required. Applicants will be expected to work in an interdisciplinary environment and interact with a team of scientists with a wide range of expertise in biophysics and biophysical chemistry.


To apply online for this vacancy and to view further information about the role, please visit: http://www.jobs.cam.ac.uk/job/15840/


This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the ‘Apply online’ button and register an account with the University’s Web Recruitment System (if you have not already) and log in before completing the online application form.


Please ensure that you upload your Curriculum Vitae (CV), a covering letter and publications list in the upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.


For queries relating to your application or the application process, please contact Echo Williamson (email: jw825@cam.ac.uk).


Please quote reference MA14082 on your application and in any correspondence about this vacancy.


Link: http://www.jobs.cam.ac.uk/job/15840/
Employer: University of Cambridge
Location: Cambridge, England
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: November 24th, 2017
University of CambridgeCambridge, EnglandPhDALS, FTDNov 24, 2017
Assistant Professor, Biological Sciences

Assistant Professor, Biological Sciences

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Description:

The Department of Biological Sciences in the School of Natural Sciences and Mathematics at the University of Texas at Dallas (http://www.utdallas.edu/biology/) invites applications for a faculty position at the rank of Assistant Professor. We seek to hire an outstanding scientist with research interests that complement and build on existing departmental strengths in biochemistry, cell and molecular biology, computational and systems biology, genomics, microbiology, and pathobiology (cancer, neurodegenerative disorders, and infectious disease). Since the department has the goal of expanding its research and teaching into new directions, we will also consider applications from excellent candidates in other areas of the biological sciences. Review of applications will begin immediately and will continue until the position is filled.


Link: https://jobs.utdallas.edu/postings/9167
Employer: University of Texas
Location: Dallas, Texas
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: November 22nd, 2017
University of TexasDallas, TexasPhDNDGNov 22, 2017
Research Associate, Grinberg Lab

Research Associate, Grinberg Lab

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Description:

The Staff Research Associate II (SRA II) position is for a full time lab technician (Research Assistant) to assist the Principal Investigator (PI) in neuropathology research that investigates the pathogenesis of Alzheimer’s disease, frontotemporal dementia, and related disorders at UCSF Mission bay campus (see http://grinberglab.ucsf.edu).


The candidate is expected to be open to learning new methods.


The position represents an excellent opportunity to further basic laboratory and research skills in a dynamic clinical neuroscience environment. The successful applicant will be an energetic, team player, self-directed learner with a keen interest in research.


The candidate will need excellent dexterity for sectioning tissue using a microtome.


Link: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?partnerid=6495&siteid=5226&jobId=2612662
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: BA or BS
Conditions: FTD
Job posted: November 22nd, 2017
University of CaliforniaSan Francisco, CABA or BSFTDNov 22, 2017
Research Associate, Lakatos Lab

Research Associate, Lakatos Lab

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Description:

An MRC funded postdoctoral position is available in the laboratory of Dr Andras Lakatos at the University of Cambridge. The research group focuses on regulators of transcriptional networks and novel signalling pathways in astrocyte-neuron-synapse interactions. In specific, this exciting project is aimed at elucidating mechanisms underlying novel cell-communication pathways under physiological conditions, injury and in neurodegenerative diseases, such as Motor Neuron Disease (MND)/Amyotrophic Lateral Sclerosis (ALS).


The successful applicant will use cutting-edge technologies, including in vivo/ex vivo transgenic mouse and/or translational human disease models in combination with computational approaches to reveal astrocyte-mediated mechanisms driving degeneration or recovery of the neuronal network.


The candidate must have a PhD (or equivalent) in neurosciences or biological sciences with first author publication(s) and a strong background in mammalian cell culture techniques, cell and molecular biology. Experience in at least one of the following areas is desired: human stem cell biology, CRISPR/Cas9 genome editing, calcium imaging, analysis of RNA-sequencing and proteomic data, computational modelling and network analysis. We seek a candidate with strong organisational skills and aptitude for semi-independent and team work.


The post is a unique opportunity for a scientist in regenerative neurobiology, who will join a dynamic group of basic and clinician scientists and will interact with collaborating groups in the UK and USA to pursue fundamental and clinically relevant questions in neurosciences.


If you have any questions about this vacancy or the application process, please contact Dr Andras Lakatos by email at the first instance (AL291@cam.ac.uk). For further information about the laboratory please visit: http://www.neuroscience.cam.ac.uk/directory/profile.php?lakand


To apply online for this vacancy and to view further information about the role, please visit:

http://www.jobs.cam.ac.uk/job/15785/


Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.


Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.


Closing date for applications is the 17th December 2017.


Link: http://www.jobs.cam.ac.uk/job/15785/
Employer: University of Cambridge
Location: Cambridge, England
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: November 20th, 2017
Applications close: December 17th, 2017
University of CambridgeCambridge, EnglandPhDALSNov 20, 2017
Chair, Neurological Sciences

Chair, Neurological Sciences

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Description:

The College of Medicine at Florida State University has embarked on a strategic effort to increase basic and translational research in human neuroscience. In an effort to extend our impact in neural health, we are seeking applications for the College of Medicine’s Mina Jo Powell Chair in Neurological Sciences.


Qualifications:

A senior basic- or clinician-scientist (PhD or MD) at the Associate or Full Professor level with a proven track record of excellence in creative approaches to neuroscience, generating peer-reviewed funding, and leading interdisciplinary groups. Must possess the leadership capabilities for directing their own research cluster.


Responsibilities:

The Mina Jo Powell Chair is open to an outstanding individual who specializes in using functional magnetic resonance imaging as a core component of their research program, and will have full access to a new research-dedicated 3T Siemens MAGNETOM Prisma in the MRI facility housed at the College of Medicine.


The Mina Jo Powell Chair is expected to build upon existing strengths in neuroimaging, neurobiology of sex differences in anxiety and depression, traumatic brain injury, spinal cord injury, sex differences in development and behavior, synaptic physiology underlying cortical function and epilepsy, psychopharmacology and developmental basis of mental health disorders, plasticity of neuronal circuits and their pathology in neurodevelopmental disorders, neurodegeneration and neuropharmacology of CNS dopamine systems related to neuromuscular disorders.


How to Apply:


To apply, please go to: www.jobs.fsu.edu and search by job ID 42346. In addition to an online application, please upload with the application as well as send the following in a single PDF file: a detailed curriculum vitae page overview of current and future research plans, and a list of at least three professional references to:

Dr. Jeffrey N Joyce, Chair of the Search Committee, Jeffrey.Joyce@med.fsu.edu

Natasha Coen, Sr. Administrative Specialist, Natasha.Coen@med.fsu.edu.


Link: https://jobs.sciencecareers.org/job/470884/associate-professor-professor-and-endowed-chair/?TrackID=178258&utm_source=Widget&utm_medium=neurodegeneration&utm_campaign=ALS#sc=widget&me=referral&cm=178258
Employer: Florida State University College of Medicine
Location: Tallahassee, Florida
Sector: Academia
Degree required: PhD or MD
Conditions: NDG
Job posted: November 16th, 2017
Florida State University College of MedicineTallahassee, FloridaPhD or MDNDGNov 16, 2017

Industry

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Principal Scientist, Neuroscience, In Vivo Pharmacology

Principal Scientist, Neuroscience, In Vivo Pharmacology

(Click title to open job details in a new window.)
Description:

The successful candidate will be a member of the West Point Pharmacology Department, a department that provides in vitro and in vivo pharmacology solutions to support a wide variety of neuroscience, infectious disease, and cardio-metabolic programs.


The successful candidate will have had experience in designing and executing in vivo behavioral and physiological experiments to determine the efficacy of novel compounds designed to have efficacy across a range of neuroscience indications including neurodegeneration, psychiatry, and pain. In addition, the candidate should have extensive experience in developing novel models in support of neuroscience programs; have experience in PK/PD modeling and a solid grounding in drug discovery research in the Biotech or Pharmaceutical industry. The individual would be expected to act as an independent scientist in leading the in vivo pharmacological needs of multiple projects in a wide array of neuroscience indications, and have shown ability to lead in the field.


Key responsibilities:

*Performing all aspects of running in vivo models supporting neuroscience indications to drive forward the goals of the Pharmacology and Neuroscience departments.

*Core and project team member of multiple projects across neuroscience discovery programs. Demonstrate a high degree of influence and leadership in these projects through past experiences at this level.

*Provide mentorship and supervisory role to researchers at scientist level within the team.

*Deliver scientific, regulatory and project management leadership within and across departments and line functions.

*Interface with other departments including disease area biologists, safety assessment, chemistry, and pharmacokinetics & drug metabolism

*Work with groups external to Merck e.g. contract resource organizations to access novel assays and/or manage workload effectively.


Qualifications:


Education: A Ph.D. in Neuroscience or pharmacology (with neuroscience background)


Required:

*A minimum of 8 years of experience post PhD with at least 5 years in the biotechnology or pharmaceutical industries.

*Proven ability to drive projects forward

*Extensive knowledge and hands on experience of translational neuroscience animal models

*Track record of performance on drug discovery teams

*Experience developing practical research strategies, translating strategy into experiments

*Experience managing and mentoring direct reports

*Ability to work in a matrixed organization


Preferred:

*Hands on experience with cognitive / behavioral experiments with in vivo and/or primates.

*Hands on experience with In vivo physiological and/or electrophysiological experiments in in vivo and/or primates.

*Hands on experience with in vivo neurodegenerative experiments in rodents and/or primates


Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life.


If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to staffingaadar@merck.com.


Link: https://jobs.sciencecareers.org/job/474476/principal-scientist-in-vivo-pharmacology-neuroscience/
Employer: Merck
Location: West Point, PA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: January 11th, 2018
MerckWest Point, PAPhDNDGJan 11, 2018
NEW! Research Associate, Process Analytics

Research Associate, Process Analytics

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Description:

Voyager Therapeutics is a gene therapy company developing life-changing treatments for severe neurological diseases. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector optimization and engineering, dosing techniques, as well as process development and production. The company’s pipeline is focused on severe neurological diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease, spinal muscular atrophy (SMA), frontotemporal dementia and Alzheimer’s disease and severe chronic pain.


Voyager is seeking a highly motivated Research Associate for a position within the analytical development group. The qualified candidate will maintain adherent cell culture and plate cells for bioassays using aseptic conditions. The candidate will also perform analysis of process development and pre-clinical grade materials. After product testing, the candidate will be responsible for data analysis as well as reporting of data. Responsibilities include, but not limited to the following. This position in located in Cambridge, MA.


· Maintain cell culture and plate cells for bioassays under aseptic conditions


· Independently, conduct assays on in-process and final products


· Perform routine assays on a weekly basis to determine product quality


· Analyze data and record results into ELN/LIMS in a timely manner


· Formulation and testing of buffers and materials needed for routine assays


· Perform both qualitative and quantitative analysis of proteins (ELISA, Western blot, silver stain/PAGE) and DNA (qPCR, agarose gel electrophoresis)


Qualifications


· BS in Biochemistry/Biology/Chemistry/Virology or a related field


· 1-3 years of relevant experience in (Biotech/Biopharma) industry


· Experience testing AAV or similar gene therapy viral vectors highly preferred


· Experience with aseptic adherent mammalian cell culture maintenance is important for qualifying for this position


· Strong desire to learn multiple techniques and willingness to provide support as required


· Significant attention to detail and accuracy in following protocols


· Demonstrated ability to be highly productive in a fluid, fast-paced and team work environment


Link: https://www.linkedin.com/jobs/view/563408945/
Employer: Voyager Therapeutics
Location: Cambridge, MA
Sector: Industry
Degree required: BS
Conditions: ALS
Job posted: January 8th, 2018
Voyager TherapeuticsCambridge, MABSALSJan 08, 2018
Postdoctoral Fellow

Postdoctoral Fellow

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Description:

Braingineering Technologies SARL (BTech) is an innovative Biotech company focusing on novel human neurodegenerative disease specific 3D cell models with applications in drug development and toxicity testing. BTech has its offices and labs in Luxembourg. We are seeking a full time postdoctoral researcher. Initial contract length is 2 years with the option of renewal.


Role and Responsibilities

• Lead operations in the field of Gene-Editing projects.

• Contribution to a variety of cell biological and molecular biological tasks.

• Independent planning and execution of projects.

• Training and supervision.

• Communication of results internally and externally.


Essential skills

• Proven previous experience in CRISPR/Cas9 mediated gene-editing is a must.

• Experience in the work with human stem cells.

• Previous experience in the neurodegeneration sector would be a great advantage.

• Ability to think strategically and critically evaluate risks to regulatory activities

• Very good command of English language is essential, while additional good knowledge of German and/or French would be an asset.

• Finally, the ability to effectively organise, prioritise and execute tasks in a highly dynamic environment is required.


Applications (in English) should contain the following documents:

• A detailed curriculum vitae

• Cover letter

• Name and addresses of referees


Please apply via email to Jens Schwamborn (schwamborn@braingineering.lu) until January 21st.


Link: https://www.nature.com/naturejobs/science/jobs/632905-postdoctoral-researcher-crispr-cas9-gene-editing
Employer: Braingineering Technologies SARL
Location: Esch-sur-Alzette, Luxembourg
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: December 22nd, 2017
Applications close: January 21st, 2018
Braingineering Technologies SARLEsch-sur-Alzette, LuxembourgPhDNDGDec 22, 2017
Principal Scientist, Neuroscience

Principal Scientist, Neuroscience

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Description:

We are seeking a Research Principal Scientist to join a vibrant and growing group currently focusing on developing new and effective therapeutics for neurodegenerative diseases, migraine and neuropathic pain. This position is within the Neuroscience Therapeutic Area, a key component of the Discovery Research unit at Amgen’s site in Cambridge, MA. The Principal Scientist will focus on in vivo model test systems and the development and validation of mechanism based pharmacodynamic measures supporting characterization and pipeline advancement of novel CNS therapeutics.


Link: https://careers.amgen.com/job/7902690/principal-scientist-in-vivo-biology-lead-neuroscience-cambridge-ma/
Employer: Amgen
Location: Cambridge, MA
Sector: Industry
Degree required: BS, MS or PhD
Conditions: ALS
Job posted: December 11th, 2017
AmgenCambridge, MABS, MS or PhDALSDec 11, 2017
Executive Director, Clinical Research, Rare and Neurological Diseases

Executive Director, Clinical Research, Rare and Neurological Diseases

(Click title to open job details in a new window.)
Description:

The Rare Disease Research Unit is looking for a talented senior physician scientist to join our team developing transformational new treatments in rare Neuromuscular, Neurodevelopmental and Neurodegenerative diseases using AAV gene therapy. This individual will focus on the challenging translational, clinical and regulatory problems presented by gene therapy in rare (often) pediatric indications, including natural history studies, novel endpoint development and clinical trial design. The candidate will be accountable for the delivery of translational and clinical development plans for AAV gene therapy programs in multiple rare neurological indications, and will be skilled in early clinical program design and conduct from pre-clinical stages to POC. Similar activities will be required for programs exploiting other treatment modalities. Experience and proven collaborative skills with basic and clinical scientists, investigators, regulators and safety functions are essential.


*Accountable for the development of translational and clinical development plans in rare Neuromuscular, Neurodevelopmental and *Neurodegenerative diseases using AAV gene therapy and other modalities for RDRU projects

*Lead interactions with colleagues in Global Product Development and Pfizer Innovative Health with regard to clinical development planning and product concept development for AAV gene therapies and other modalities.

*Partner with functions in Early Clinical Development as needed to ensure that biomarker and quantitative development plans are enabled in all relevant Rare Neuro programs to help determine early signs of efficacy and proof of concept, patient stratification, etc.

*Serve as a clinical champion for early development Rare Neuro programs in AAV gene therapy and other modalities

*Help to build, develop, and lead motivated and engaged matrix teams

*Provide oversight to clinical teams, including:

*Lead preparation of clinical sections of all relevant regulatory filings (IND, Orphan designation, Fast track and breakthrough designations – including NDA/BLA when required).

*Oversee management of studies and serve as expert on clinical and medical issues, including medical monitoring where necessary

*Oversee review of study data, including safety monitoring and SAE reporting

*Oversee writing of final study reports and preparation of documents for submission

*Establish and support relationships with external experts, consultants, key opinion leaders, to ensure implementation of latest clinical thinking and guidelines into clinical development plans and study designs

*Serve as medical and technical resource for clinical issues raised by internal and external collaborators, investigators, consultants and contractors

*Mentor or supervise other clinicians to expand drug development understanding and provide development opportunities

*Foster a transparent environment that encourages strong partnerships and mutual trust between teams, sub-teams, and therapeutic areas.

*Represent the company at scientific meetings and presentations, interactions with rare disease foundations, as well as other public relations opportunities

*Assist in the development of publications, abstracts, and presentations

*Support business development activities as needed, including due diligence activities.

*Maintain up-to-date knowledge of scientific and clinical published literature in relevant therapeutic areas including the key clinical development issues.


Link: https://pfizer.wd1.myworkdayjobs.com/en-US/PfizerCareers/job/United-States---Massachusetts---Cambridge/Executive-Director-Clinical-Research-Rare-Neurological-Disease--MD-Required-_1623774?source=Linkedin
Employer: Pfizer
Location: Cambridge, MA
Sector: Industry
Degree required: MD or MD/PhD
Conditions: NDG
Job posted: November 29th, 2017
PfizerCambridge, MAMD or MD/PhDNDGNov 29, 2017
Scientist I/II

Scientist I/II

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Description:

Neurology Research at Biogen seeks a highly motivated and experienced associate scientist to join the new initiative on ALS (amyotrophic lateral sclerosis). The Neurology department is responsible for discovery research on pathogenic mechanisms of neurodegenerative disorders and translating these findings into novel strategies for therapeutic intervention.


The successful candidate will execute in vivo experiments to support the validation of novel drug targets and the development of small- and large-molecule drugs for the treatment of ALS. A major component of this work will be the assessment of drug candidates in a multiple rodent models, using a wide variety of morphological and functional endpoints, working closely with members of the ALS team as well as multiple internal and external collaborators. You will work in a fast paced, highly collaborative team environment at an exciting period for ALS research.


Qualifications

• Familiarity with genetic models of neurodegenerative diseases and experience with conducting either pharmacological or genetic tests in those models

• Must demonstrate a keen knowledge of experimental design, underlying scientific principles, and the ability to rigorously analyze and assess results and generate clear reports

• Previous experience handling animals is required and should include some of the following: dosing, dissection, and/or surgery. Neo natal rodent survival surgery strongly desired.

• Experience in histopathological techniques, such as perfusion, cryostat sectioning, immunostaining is strongly preferred

• Experience in molecular biology and biochemical techniques, such as DNA cloning, electrophoresis, and PCR is preferred

• Experience with behavioral or electrophysiological endpoints would be a positive addition

• Excellent communication and organizational skills are critical.


Link: https://sjobs.brassring.com/TGnewUI/Search/home/HomeWithPreLoad?PageType=JobDetails&noback=0&partnerid=169&siteid=5140&jobid=793781#jobDetails=793781_5140
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: ALS
Job posted: November 29th, 2017
BiogenCambridge, MAPhDALSNov 29, 2017
Senior Scientist

Senior Scientist

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Description:

Yumanity is seeking a creative, talented and versatile Ph.D scientist to join our interdisciplinary team to help advance our novel drug discovery programs. This position will be laboratory based, and requires strong experimental skills in neurobiology and assay development. The scientist in this position will collaborate across all Yumanity’s core platforms, including yeast phenotypic screening, target identification and chemistry.


Responsibilities include:


*Developing neurodegenerative disease models in mammalian cells including cell lines, rodent primary neurons and human iPS cell-derived neurons.


*Developing assays to validate the activity and target of the compounds derived from yeast high-throughput screening.


*Interacting and collaborating with yeast screening, target ID and medicinal chemistry teams to validate compound and target activities in mammalian cells.


Experience and skills required:


*Education: Ph.D. degree in neuroscience, cell biology, biochemistry, or relevant field with 2+ year of postdoctoral experience.


*Highly desirable to have experience in modeling neurodegenerative diseases in neurons using misfolding-prone proteins such as alpha-synuclein, APOE4 and others, skills in developing and miniaturizing assays to measure cellular responses to pathologic processes, highly versatile and team-based mindset.


*Excellent verbal, written communication and presentation skills are essential.


Link: https://www.linkedin.com/jobs/view/462507144/
Employer: Yumanity Therapeutics
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: November 28th, 2017
Yumanity TherapeuticsCambridge, MAPhDNDGNov 28, 2017
Senior Scientist

Senior Scientist

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Description:

Evotec’s headquarters in Hamburg (Germany) is seeking a highly motivated and creative Senior Scientist (f/m) Biomarker in Neurodegeneration Research full-time and permanent to join our Neurobiology Department and help drive projects in the research area of Huntington’s Disease and other neurodegenerative disorders.


Your key responsibilities:

*Manage, lead biomarker projects and provide scientific expertise to other ongoing projects of the Biomarker group

*Support the group leader with people and scientific management and business development

*Actively contribute to and support collaborative initiatives and liaise with external scientists and customers

*Train and supervise a small team of technical staff to design and execute immunoassay development, cellular and biochemical assays

*Design, develop, implement and validate in vitro and biochemical and immuno-assays on various technology platforms including ELISA, MSD, Singulex and hTRF to evaluate efficacy, PK/PD relationship, and novel biomarkers to characterize molecules for potential therapeutic effects

*Analyze and summarize data for presentations, reports, publications and patents


Link: https://www.linkedin.com/jobs/view/527410471/
Employer: Evotec
Location: Hamburg, Germany
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: November 24th, 2017
EvotecHamburg, GermanyPhDNDGNov 24, 2017

Non-Profit and Government

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Associate Scientist

Associate Scientist

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Description:

The ALS Therapy Development Institute (ALS TDI) has an opening for a full-time Associate Scientist working in the Translational Research group. The Associate Scientist will be part of the team working to develop patient-derived induced pluripotent stem cell (iPSc) collection, as well as the development and implementation of cell-based high content screens for target and drug discovery.


Responsibilities include but are not limited to:


*Isolation and banking of patient-derived primary cells

*Generating and characterizing of iPSc and their differentiated derivatives

*Assisting in the development and characterization of isogenic genome-edited and patient-derived cell-based screening models


Link: https://www.indeed.com/viewjob?jk=6b88fbc755066cdf&q=amyotrophic&tk=1c3bcvhu05ut4fbr&from=web
Employer: ALS Therapy Development Institute
Location: Cambridge, MA
Sector: Non-Profit
Degree required: BA or BS
Conditions: ALS
Job posted: January 5th, 2018
ALS Therapy Development InstituteCambridge, MABA or BSALSJan 05, 2018
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