Figure 1. Micrographs of spinal cord motoneurons showing SOD1-immunoreactive inclusions.
Image credit: Forsberg, et. al. 2010 under CC BY license

Job Opportunities

To submit any new job opportunities for this list, please email ALSjobs@prize4life.org. List the employer, location, closing date if applicable, and a link to more information. Jobs are removed after 3 months, unless requested otherwise.

This free job bulletin board aims to help scientists identify job opportunities in the field of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Positions described as broadly spanning neurodegenerative diseases (NDG) are noted as ‘NDG‘. The job listing includes research positions at all levels, as well as non-research positions for which a research background at the MS, PhD, or MD level is required.


Click the title of any table column to sort.

Academia

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
Graduate Studentship, De Vos Lab

Graduate Studentship, De Vos Lab

(Click title to open job details in a new window.)
Description:

Applications are now being invited for a three-year Basic Science PhD Studentship funded by Alzheimer’s Society, starting in October 2017. The successful candidate will join an established training programme at the Sheffield Institute for Translational neuroscience (SITraN) in the group of Dr Kurt De Vos. Expansions of a noncoding GGGGCC hexanucleotide repeat in the C9ORF72 gene are the most common genetic defect found to date in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). How the repeat expansion causes disease is not known, but appears to involve both loss-of-function (C9ORF72 haploinsufficiency), and gain-of-function (repeat-associated non-ATG (RAN) translation, RNA toxicity) mechanisms. To unravel the ways in which C9orf72 expansions cause disease it is crucial to understand the normal functions of the C9orf72 protein. In this project we will investigate how the cellular levels of C9orf72 are regulated and leverage this knowledge to devise novel therapeutic strategies. Candidates must have a first or upper second class honors degree or significant research experience.


How to apply:

Please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply Please clearly state the prospective main supervisor in the respective box and select ‘Neuroscience’ as the department.


Link: https://www.linkedin.com/jobs/view/319502398/
Employer: University of Sheffield
Location: Sheffield, England
Sector: Academia
Degree required: BS
Conditions: ALS, FTD
Job posted: April 14th, 2017
University of SheffieldSheffield, EnglandBSALS, FTDApr 14, 2017
Postdoctoral Fellow, Tamgüney Lab

Postdoctoral Fellow, Tamgüney Lab

(Click title to open job details in a new window.)
Description:

The laboratory of Dr. Erdem Gültekin Tamgüney is focused on understanding how disease-associated proteins misfold, aggregate, spread, and damage the brain. We are inviting applications for a postdoctoral position in this group to work with mouse models of neurodegeneration to elucidate disease mechanisms causing synucleinopathies and amyotrophic lateral sclerosis.


Your profile:

*The successful candidate will be fluent in English.

*At least 3 years of experience in working with mouse models of neurodegeneration, in paraffin- and cryosectioning, in immunohistochemical

and immunofluorescence staining of tissue sections, and in confocal

microscopy.

*Experience in preparing and culturing primary neurons and organotypic

brain slices, in conducting behavioral experiments, in protein purification, or with biophysical methods to study protein misfolding and aggregation is a plus.


Applicants should send a letter of research interests, curriculum vitae and two references as a single PDF File to: application@dzne.de


Link: https://www.dzne.de/en/job-vacancies/job/postdoctoral-researcher-fm-in-animal-models-of-neurodegeneration-code-146220174-1.html
Employer: German Center for Neurodegenerative Diseases (DZNE)
Location: Bonn, Germany
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: April 13th, 2017
Applications close: May 7th, 2017
German Center for Neurodegenerative Diseases (DZNE)Bonn, GermanyPhDALSApr 13, 2017
Postdoctoral Fellow, Sun Lab

Postdoctoral Fellow, Sun Lab

(Click title to open job details in a new window.)
Description:

Postdoctoral opportunities are available in Dr. Shuying Sun’s laboratory at Johns Hopkins University School of Medicine. The lab will explore the fascinating frontiers of RNA metabolism dysfunction and RNA-targeting therapy in neurodegenerative diseases by combining molecular and cellular approaches, genome editing, proteomic, genomic and screening platforms.


The nervous system has extremely complex RNA processing regulation and dysfunction of RNA metabolism has emerged to play crucial roles in multiple neurological diseases. Mutations and pathologies of several RNA-binding proteins are found to be associated with neurodegeneration in both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). An alternative RNA-mediated toxicity arises from microsatellite repeat instability in the human genome. The expanded repeat-containing RNAs could potentially induce neuron toxicity by disrupting protein and RNA homeostasis through various mechanisms.


The Sun lab is interested in deciphering the molecular mechanisms of disease pathogenesis and seeks to translate the mechanistic findings to therapeutic target development to advance treatment options against neurodegenerative diseases. We are looking for highly motivated postdoc fellows with solid PhD training in biochemistry, molecular and cellular biology. Experiences with RNA biology, neuroscience or bioinformatics are preferred but not limited to. You will join a strong and highly interactive science community at Johns Hopkins. Interested candidates should provide a cover letter (with statement of research interest and career goals), CV and the contact information for three references to Dr. Shuying Sun at shuying.sun@jhmi.edu. Please visit our lab website at http://labs.pathology.jhu.edu/sun/ for additional information.


Link: http://www.nature.com/naturejobs/science/jobs/611781-postdoctoral-position-on-rna-biology-and-neurodegenerative-disease
Employer: Johns Hopkins University
Location: Baltimore, MD
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: April 11th, 2017
Applications close: June 10th, 2017
Johns Hopkins UniversityBaltimore, MDPhDALS, FTDApr 11, 2017
Research Associate II

Research Associate II

(Click title to open job details in a new window.)
Description:

Incumbent will assist with new metabolic targets to treat neurodegenerative disease. Under general supervision, assist the principal investigator and laboratory members in developing novel techniques and models to study the intersection between mitochondrial metabolism and neural physiology. Research duties will include assisting with animal handling, tissue harvest, dissections, and primary neural cell preparations. Additional responsibilities will include biochemical assays (immunoblot analysis ,subcellular fractionation), molecular biology (qRT-PCR and genetic manipulation of cells with siRNA, viral vectors, or CRISPR technology), and specialized metabolic assays (Seahorse XF analysis, plate-based enzymatic assays). Preparation of samples for high-content imaging or mass spectrometry analysis will also be required. Further duties will include general lab maintenance responsibilities, such as organization and management of supplies, chemical reagents, and animals.


Job Qualifications

Demonstrated knowledge of basic biochemistry and molecular biology principles. B.S. in Biology, Neuroscience, or related field is preferred. Ability to use basic laboratory equipment, including centrifuge, pH meter, incubators, tissue culture hoods, and electrophoresis apparatus. Demonstrated experience with animal handling, injections, tissue harvests, and dissections. Ability to ensure compliance with all laboratory safety protocols. Ability to learn new methods and protocols and to adapt these to current laboratory situations. Ability to create and maintain records accurately. Ability to work independently and follow through on assignments with minimal supervision, and conduct follow-up experiments based on previous results. Interpersonal and communication skills to effectively interact with a diverse group of faculty, staff, postdoctoral fellows and students and to effectively convey experimental results. Ability to train and supervise undergraduate students. Prior experience with brain dissection, slice cultures, and primary cell preparations from the brain (neurons, astrocytes, etc.) is preferred.


Link: http://www.uclahealthcareers.org/all-jobs/Research-Associate-II/H89695
Employer: University of California
Location: Los Angeles, CA
Sector: Academia
Degree required: BS
Conditions: NDG
Job posted: April 2nd, 2017
University of CaliforniaLos Angeles, CABSNDGApr 02, 2017
Physician Scientist, Tenure-Track

Physician Scientist, Tenure-Track

(Click title to open job details in a new window.)
Description:

The Center for Translational Medicine (CTM) at the Lewis Katz School of Medicine at Temple University is seeking qualified candidates and candidate nominations for a Tenure Track Faculty Physician-Scientist dedicated to neurodegeneration research. This position will also have clinical responsibilities and a joint appointment in the Department of Neurology.


Successful candidates will hold an MD or MD/PhD degree with the ability to obtain a medical license within the commonwealth of Pennsylvania. A focus in basic science or translational research in adult-onset neurodegenerative diseases including Alzheimer’s, Parkinson’s, ALS or Dementia is required, as well as a strong academic record. Academic appointment is available at all levels and competitive packages will be offered based on qualifications. Candidates with current independent funding are preferred.


Interested candidates should submit a current curriculum vita with complete contact information, and letters of interest to the address below. Contributions to diversity are strongly encouraged.


Walter J. Koch, PhD, William Wikoff Smith Endowed Chair in Cardiovascular Medicine, Professor and Chair, Pharmacology, and Professor and Director, Center for Translational Medicine; C/O Debbie Hinnerschitz, DASPR, Physician Recruiter, Lewis Katz School of Medicine at Temple University, 3420 N. Broad Street, MRB 101, Philadelphia, PA, 19140,


Email: debbie.hinnerschitz@tuhs.temple.edu.

Phone: 215-707-4419 Fax: 215-707-9452


Link: http://jobs.sciencecareers.org/job/445609/tenure-track-faculty-research-physician-center-for-translational-medicine-neurodegeneration/
Employer: Temple University
Location: Philadelphia, PA
Sector: Academia
Degree required: MD or MD/PhD
Conditions: ALS
Job posted: March 31st, 2017
Temple UniversityPhiladelphia, PAMD or MD/PhDALSMar 31, 2017
Postdoctoral Fellow, Cai Lab

Postdoctoral Fellow, Cai Lab

(Click title to open job details in a new window.)
Description:

The Department of Cell Biology and Neuroscience at Rutgers University is currently accepting applications for a postdoctoral position to study (1) the cellular mechanisms regulating autophagy-lysosomal function; (2) how altered axonal transport impacts the autophagy-lysosomal system, leading to axonal degeneration; (3) how deficits in the endolysosomal pathway contribute to the dysregulation of neuronal signaling. Given that defective axonal transport has been implicated in the pathogenesis of major neurodegenerative diseases, our studies will yield fundamental information to advance our understanding of human neurodegenerative diseases. Candidates for this position should hold a PhD with a strong research background in neurobiology or cell biology, at least in one of these areas: membrane trafficking, organelle transport, mitochondrial quality control, neuronal signaling, and neurodegenerative mouse models. Interested individuals should send CV, a personal statement describing research interests, and names and details of 3 references to cai@biology.rutgers.edu. Att: Qian Cai, M.D., Ph.D. Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Nelson Biological Laboratories, Busch Campus, 604 Allison Road, Piscataway, NJ 08854. Lab Webpage: https://cbn.rutgers.edu/cb-profile/userprofile/qc29 Application review will begin immediately and will continue until a suitable candidate is selected.


Link: http://jobs.sciencecareers.org/job/445596/postdoctoral-fellow-in-neurobiology-and-cell-biology/
Employer: Rutgers University
Location: Piscataway, NJ
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: March 31st, 2017
Rutgers UniversityPiscataway, NJPhDNDGMar 31, 2017
Postdoctoral Fellow, Talbot Lab

Postdoctoral Fellow, Talbot Lab

(Click title to open job details in a new window.)
Description:

An exciting opportunity has arisen to work as a Postdoctoral Researcher in Neurodegeneration in the Oxford Motor Neuron Disease Centre based in the John Radcliffe Hospital, Oxford. Working with Professor Kevin Talbot your research will focus on the validation of drugs of potential benefit in ALS, based on targets identified by artificial intelligence approaches. The overarching aims are to use primary cell culture from the TDP-43M337V BAC mouse model to validate drugable pathways in conjunction with industry collaborators and local researchers.


Your responsibilities and duties will include phenotyping cells in culture, including using immunofluorescence and developing skills in electrophysiology, using an established mouse model of ALS based on TDP-43 mutations to validate candidate drugs and adapting existing and developing new scientific techniques and experimental protocols. Your role will also involve you managing your own academic research and administrative activities. This will involve small scale project management, to co-ordinate multiple aspects of work to meet deadlines.


You will have a PhD/DPhil in a relevant discipline or be near to completion with experience of primary neuronal cell culture and a degree in neuroscience or a related subject. You will need to manage your own workload to strict deadlines and work independently as well as contributing to the research activities of the group. Experience of working with induced pluripotent stem cells and mouse models would be advantageous.


For informal inquiries please contact kevin.talbot@ndcn.ox.ac.uk .


For further information about the project please visit: www.ndcn.ox.ac.uk/research/the-oxford-motor-neuron-disease-centre


The post is full-time for a fixed-term of 1 year in the first instance. There is a potential to renew for a further year, dependent on funding


Only applications received before 12.00 midday on Wednesday 26 April 2017 will be considered. Interviews will be held as soon as possible thereafter.


Link: http://www.nature.com/naturejobs/science/jobs/610493-postdoctoral-researcher-in-neurodegeneration
Employer: University of Oxford
Location: Oxford, England
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: March 26th, 2017
Applications close: April 26th, 2017
University of OxfordOxford, EnglandPhDALSMar 26, 2017
Research Specialist

Research Specialist

(Click title to open job details in a new window.)
Description:

A full-time position is available in the laboratory of Dr. Corey McMillan in the Department of Neurology at the University of Pennsylvania. This laboratory focuses on translational neuroscience questions related to improving the diagnostic and prognostic biomarkers of related neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). We also explore genotype and phenotype relationships using a multimodal approach that integrates clinical, imaging, genetic, and biofluid datasets. Applicant responsibilities will include collection of psychometric and imaging data from patients with ALS and/or FTD, preliminary statistical analyses, database management, processing biofluid samples, and administrative coordination with consortia collaborators.


Link: http://jobs.hr.upenn.edu/postings/27064
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: BS
Conditions: ALS, FTD
Job posted: March 24th, 2017
University of PennsylvaniaPhiladelphia, PABSALS, FTDMar 24, 2017
Research Associate

Research Associate

(Click title to open job details in a new window.)
Description:

The position is for a full time Staff Research Associate to assist the PI in neuropathology research that investigates the pathogenesis of Alzheimer’s disease, frontotemporal dementia, and related disorders at UCSF Mission bay campus. The Staff Research Associate is expected to be open to learning new methods. One year of relevant laboratory experience including laboratory histology (embedding, cutting, immunohistochemistry, and coverslipping).The position represents an excellent opportunity to further basic laboratory and research skills in a dynamic clinical neuroscience environment. The successful individual will be an energetic, team player, self-directed learner with a keen interest in research.


Link: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?jobId=2469164&PartnerId=6495&SiteId=5226&codes=IND
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: BA or BS
Conditions: FTD
Job posted: March 23rd, 2017
University of CaliforniaSan Francisco, CABA or BSFTDMar 23, 2017
Assistant, Associate or Full Professor

Assistant, Associate or Full Professor

(Click title to open job details in a new window.)
Description:

The Black Family Stem Cell Institute at the Icahn School of Medicine at Mount Sinai is seeking outstanding applicants (PhD or MD/PhD) for a full-time, potential tenured position at the rank of Assistant Professor, Associate Professor, or Professor. We are a well-established, state-of-the-art research program with a distinguished publication record in stem cell biology and regenerative medicine, laying the scientific groundwork for understanding and manipulating stem cell behavior and developing sophisticated strategies for modeling and treating diseases ranging from blood disorders to neurodegeneration. Preference will be given to outstanding candidates who can complement and enhance existing strengths within the Black Family Stem Cell Institute and work collaboratively with additional world-class researchers at sister institutes at Mount Sinai.


A culture of innovation and a passion for pushing the boundaries of knowledge are integral to all activities at Icahn School of Medicine at Mount Sinai, driving us on a daily basis to challenge existing limitations of science and medicine to create and discover what was previously thought to be impossible. Mount Sinai is at the heart of an exciting and innovative environment and is a friendly and collegial place to work. New York City offers an unrivaled array of cultural and recreational attractions.


Interested candidates should send a copy of their curriculum vitae, a brief letter outlining their interests and names of three references to Thomas Zwaka, MD, PhD thomas.zwaka@mssm.edu by June 1, 2017.


Link: http://jobs.sciencecareers.org/job/443315/black-family-stem-cell-institute-mount-sinai-new-york-full-time-potential-tenured-faculty-position/
Employer: Mount Sinai School of Medicine
Location: New York, NY
Sector: Academia
Degree required: PhD or MD/PhD
Conditions: NDG
Job posted: March 22nd, 2017
Applications close: June 1st, 2017
Mount Sinai School of MedicineNew York, NYPhD or MD/PhDNDGMar 22, 2017
Research Associate, Fraenkel Lab

Research Associate, Fraenkel Lab

(Click title to open job details in a new window.)
Description:

The research group of Professor Ernest Fraenkel seeks a talented scientist to participate in an unprecedented study of the neurodegenerative disease ALS. Working with researchers at clinical and academic institutions across the United States, we are gathering data on approximately 1,000 ALS patients and controls. Induced pluripotent stem cell (iPSC) lines are being derived from each individual and these are being used to generate motor neurons for a wide range of omic studies. Our collaboration seeks to identify different subtypes of the disease, identify correlations between molecular pathways and clinical symptoms, and propose therapeutic strategies.


The research associate will be responsible for generation of epigenomic data from these patient-derived iPSC lines; work closely with collaborators to coordinate the study; and work closely with in-house computational biology team, which is integrating omic and clinical data. Will take a leading role in deriving hypotheses from the computational analyses and designing follow up experiments, using the iPSC lines and post-mortem tissue.


Requirements:


Minimum of two years’ experience with next-generation sequencing technologies, especially ATAC-Seq and ChIP-Seq.

Experience with mammalian cell culture; experience with epigenetic methods and knowledge of neurobiology.

Experience with culturing induced pluripotent stem cells (IPSCs), CRISPR/Cas9 and RNA interference, basic skills in data management and statistical analysis, and high-throughput automation are preferred.

Apply:


For more information, and to apply please visit the MIT website (referencing job #14485) at: http://careers.mit.edu/


Link: https://www.linkedin.com/jobs/view/273974569/
Employer: MIT
Location: Cambridge, MA
Sector: Academia
Degree required: BS
Conditions: ALS
Job posted: March 20th, 2017
MITCambridge, MABSALSMar 20, 2017
Assistant or Full Professor, Chemical Biology

Assistant or Full Professor, Chemical Biology

(Click title to open job details in a new window.)
Description:

Sanford Burnham Prebys Medical Discovery Institute (SBP) is an independent non-profit biomedical research institute that blends world-class fundamental research with drug discovery to address unmet clinical needs in the areas of cancer, neuroscience, immunity, and metabolic disorders. The Institute invests in talent, technology, and partnerships to accelerate the translation of laboratory discoveries that will have the greatest impact on patients. Recognized for its world-class NCI-designated Cancer Center and the Conrad Prebys Center for Chemical Genomics, SBP employs more than 1,100 scientists and staff in La Jolla (San Diego), California, and Lake Nona (Orlando), Florida.


We are seeking junior, mid-career, and senior faculty to engage in cutting-edge research programs in Chemical Biology at SBP. Candidates will have demonstrated expertise in one or more of the following areas of interest: chemical biology, medicinal chemistry, small molecule probe/drug design, pharmacology, structural biology, assay development, and screening technologies. SBP is a highly collaborative environment and the successful candidate will have opportunities to collaborate in multiple areas, including but not limited to, proteostasis, epigenetics, cancer metabolism, immunology/immune-oncology, infectious diseases, ER stress, autophagy, stem cells, neurodegeneration and aging. Sanford Burnham Prebys provides state-of-the-art laboratories and shared resources supported by a collaborative work environment.


The faculty positions require a Ph.D. or M.D./Ph.D. and an outstanding record of publications and research accomplishments relevant to the focus areas. Chosen candidates are expected to establish well-supported, rigorous and competitive research programs based on fundamental mechanisms that can address unmet clinical needs.


To apply for consideration:


Interested applicants should send their CV, together with a cover letter, a short summary of past accomplishments, an outline of future research plans and, for assistant professor candidates, the contact information for 3-4 references to facultyrecruiting@SBPdiscovery.org. All application materials should be sent as a single PDF file with code #cc0317 referenced in the subject line. Applicants are encouraged to visit the web site (www.SBPdiscovery.org) for further information.


Link: http://jobs.sciencecareers.org/job/442028/faculty-opportunity-in-chemical-biology/
Employer: Sanford Burnham Prebys Medical Discovery Institute
Location: La Jolla, CA
Sector: Academia
Degree required: PhD or MD/PhD
Conditions: NDG
Job posted: March 17th, 2017
Sanford Burnham Prebys Medical Discovery InstituteLa Jolla, CAPhD or MD/PhDNDGMar 17, 2017
Postdoctoral Fellow, Farese-Walther Lab

Postdoctoral Fellow, Farese-Walther Lab

(Click title to open job details in a new window.)
Description:

We have a postdoctoral position available in the laboratory of HHMI Investigator, Tobias Walther, Ph.D., and Robert V. Farese, Jr, M.D., who jointly run a highly collaborative group at the Harvard School of Public Health. The lab is located in the Boston Longwood medical campus and is affiliated with the Department of Genetics and Complex Disease (HSPH), the Department of Cell Biology (Harvard Medical School), the Broad Institute of MIT and Harvard, and the Howard Hughes Medical Institute.


The Walther-Farese Laboratory studies the biochemistry of cellular lipid metabolism and membrane homeostasis. We seek outstanding candidates with Ph.D. training in cellular and murine models of neurodegeneration. Projects are available in the areas of lyososome biology and frontotemporal dementia and in the area of altered sphingolipid homeostasis and neurodegenerative diseases.


Applicants should possess a Ph.D. or M.D./Ph.D. in cell biology or neurodegenerative disease research and have an outstanding publication record.


For Additional Information, Please Visit Our Webpages

https://faresewaltherlab.hms.harvard.edu/

http://cellbio.med.harvard.edu/people/faculty/farese-jr

http://cellbio.med.harvard.edu/people/faculty/walther

https://www.hhmi.org/scientists/tobias-c-walther


To Apply

Interested candidates should send a cover letter, Curriculum Vitae and three letters of reference to: robert@hsph.harvard.edu and tholmes@hsph.harvard.edu. Please include the position title, Postdoctoral Position – Cell Biology/Neurodegenerative Diseases, in the subject line.


Link: https://www.linkedin.com/jobs/view/272686325/
Employer: Harvard School of Public Health
Location: Boston, MA
Sector: Academia
Degree required: PhD or MD/PhD
Conditions: NDG
Job posted: March 16th, 2017
Harvard School of Public HealthBoston, MAPhD or MD/PhDNDGMar 16, 2017
Postdoctoral Fellow, Sajjadi Lab

Postdoctoral Fellow, Sajjadi Lab

(Click title to open job details in a new window.)
Description:

The Department of Neurology at the University of California, Irvine, invites applications for a post-doctoral fellow position in the laboratory of Dr. S. Ahmad Sajjadi MD, PhD beginning early 2017. The appointment is for 1 year with the possibility of extension upon satisfactory performance. We are seeking a highly motivated investigator with previous experience in neuropsychological assessments. Priority will be given to candidates with a recent PhD in neuroscience, psychology, or related fields and strong organizational and communication skills. The main purpose of this appointment is to establish a cohort of atypical dementia syndromes (mainly frontotemporal dementia) at the University of California, Irvine who will undergo regular clinical and neuropsychological assessments. Assessment of language and spontaneous speech will be a focus of the research and therefore, background in disorder of language will be desirable as is previous experience in neuro-imaging acquisition/analysis since the project will include structural MRI and PET scans. The position requires an individual who is an effective team player, highly organized, and innovative.


Requirements:

Candidates must possess an advanced Degree (MD or PhD) by or prior to appointment start date.


Additional Information:

Applicants who have a willingness to get involved with IRB communications, prior publication (first author), and strong written and verbal communication skills are preferred.


Salary will be commensurate with qualifications and experience.


Substantive inquiries about the positions should be directed to:

Seyed Ahmad Sajjadi, MD, PhD

Assistant Professor

Department of Neurology

200 S. Manchester, Ste. 2016

Orange, CA 92868-4280


TO APPLY: Please log onto UCI’s RECRUIT by May 12, 2017, at: https://recruit.ap.uci.edu/apply/JPF03828


Applicants should complete an online application profile and upload the following application materials electronically to be considered for the position:


Cover letter—Please discuss current research and future plans.

Curriculum vitae

Names and Contact Information of Three References

Diversity Statement


Link: https://recruit.ap.uci.edu/apply/JPF03828
Employer: University of California
Location: Irvine, CA
Sector: Academia
Degree required: MD or PhD
Conditions: FTD
Job posted: March 14th, 2017
University of CaliforniaIrvine, CAMD or PhDFTDMar 14, 2017
Manager, Stem Cell Phenotypic Screening Facility

Manager, Stem Cell Phenotypic Screening Facility

(Click title to open job details in a new window.)
Description:

Applications are invited for an experienced postdoctoral biological scientist to work as a Stem Cell Research Manager to run the MRC DPUK Dementia Stem Cell Phenotypic Screening Facility undertaking target and drug discovery projects in patient stem cell-derived neuronal models of disease.


This is an exciting opportunity to work at the interface between academic research and pharmaceutical target and drug discovery to contribute to the development of novel therapeutics for neurodegenerative disease. The Facility uses induced pluripotent stem cell (iPSC) lines differentiated into defined neuronal populations to better understand the molecular mechanisms of Parkinson’s Disease (PD), Alzheimer’s disease (AD) and related neurodegenerative disorders.


Duties will include facilities management of a major new cluster of high-end equipment for drug and target discovery (Opera Phenix high-content imager; ECHO Nanodrop dispenser; automated robotic systems; high-throughput plate readers and a stem cell culture facility); manage budgetary systems; project management; staff supervision and training; develop new strategic alliances; monitor, evaluate and enhance the performance of the facility. Applicants must hold, or be near completion of, a PhD/DPhil in a relevant area of research, or have equivalent experience, and have expertise in cellular neuroscience, cell biology or imaging relevant to analysis of neuronal phenotypes.


The post is a collaborative project between the OPDC and the MRC UK Dementia Platform (DPUK) funded for up to 3 years and is available to start as soon as possible. The post will be based in the Laboratory of Molecular Neurodegeneration, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX.


Salary: Grade 7: £31,076 – £38,183 p.a.


Informal enquiries may be directed Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk).


The closing date for applications is 12.00 midday on Wednesday 12 April 2017. Interviews will be held on 26 April 2017.


Link: https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.display_form?p_company=10&p_internal_external=E&p_display_in_irish=N&p_applicant_no=&p_recruitment_id=128072&p_process_type=&p_form_profile_detail=&p_display_apply_ind=Y&p_refresh_search=Y
Employer: University of Oxford
Location: Oxford, England
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: March 13th, 2017
Applications close: April 12th, 2017
University of OxfordOxford, EnglandPhDNDGMar 13, 2017
Assistant, Associate or Full Professor, Neuroscience

Assistant, Associate or Full Professor, Neuroscience

(Click title to open job details in a new window.)
Description:

The Department of Neurology and Weill Institute for Neurosciences at UCSF invites applications from exceptional investigators at the level of Assistant, Associate or Full Professor who are well qualified to lead investigations of amyotrophic lateral sclerosis and other neurodegenerative disorders. The successful candidate will have developed a rigorous laboratory-based research program focused on the mechanisms and treatment of neurodegeneration and will have a track record of high-impact publications. Applicants must have an MD or PhD. Outstanding credentials as a clinician and clinical investigator will be considered additional strengths, although they are not required. The individual will work closely with other investigators at the Weill Institute of Neurosciences to translate key discoveries into clinical investigations and trials. This is a rare opportunity for an accomplished and highly motivated individual to join a growing team of investigators at the new Weill Institute for Neurosciences located at UCSF’s burgeoning Mission Bay campus.


Interested applicants are encouraged to apply online at https://aprecruit.ucsf.edu/apply/JPF01314


Link: https://aprecruit.ucsf.edu/apply/JPF01314
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: MD or PhD
Conditions: ALS
Job posted: March 9th, 2017
Applications close: May 22nd, 2017
University of CaliforniaSan Francisco, CAMD or PhDALSMar 09, 2017
Postdoctoral Fellow, Xu Lab

Postdoctoral Fellow, Xu Lab

(Click title to open job details in a new window.)
Description:

A postdoctoral position is available in Zuoshang Xu’s laboratory to study mechanism of motor neuron degeneration in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease.

PhD required. Candidates with strong interest in neurodegenerative disease and proficiency in molecular biology are encouraged to apply. Candidates with additional familiarity with cell culture, imaging analysis and genomics will be considered preferentially. PhD required. Candidates with strong interest in neurodegenerative disease and proficiency in molecular biology are encouraged to apply. Candidates with additional familiarity with cell culture, imaging analysis and genomics will be considered preferentially.


To Apply: Please forward CV to: Zuoshang.Xu@umassmed.edu


Link: https://www.linkedin.com/jobs/view/289237242/
Employer: University of Massachusetts Medical School
Location: Worcester, MA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: March 5th, 2017
University of Massachusetts Medical SchoolWorcester, MAPhDALSMar 05, 2017
Neuropathologist

Neuropathologist

(Click title to open job details in a new window.)
Description:

Applications are invited for the full time (10 PAs) post of Consultant Neuropathologist at Department of Clinical Neuropathology, King’s College Hospital NHS Foundation Trust. This a new post to join another 3 Consultant Neuropathologists to provide diagnostic service for neuroscience at King’s College Hospital NHS Foundation Trust and associated hospitals.


The successful applicant is expected to have full GMC registration and have completed their certified training in neuropathology. They should hold the FRCPath in neuropathology or its equivalent. Applicants should either be on the specialist register or a specialist registrar having or within 6 months of their expected date of receipt of CCT/CESR (CP) at time of interview.


The Department of Clinical Neuropathology at King’s College Hospital NHS Foundation Trust provides clinical diagnostic services for biopsies from brain tumours, muscle and nerve in addition to diagnostic services for neurodegenerative diseases at the Brain Bank for the Institute of Psychiatry, Psychology & Neuroscience (IoPPN). The successful candidate would be expected to have a record of working well in a team and take a full part in the diagnostic neuropathology rota.


The successful applicant will also be expected to be actively engaged in expanding services such as the small fibre neuropathy and molecular biology of brain tumours and also take the lead in teaching and training for neuropathology and neurosciences.


Any interested candidate would be strongly encouraged to visit the department prior to shortlisting.


To discuss the job application and arrange an informal visit please contact Professor Safa Al-Sarraj, Head of Clinical Neuropathology and Director of the Brain Bank on 0203299 1955/1950 or safa.al-sarraj@nhs.net.


Link: http://kings.healthjobsuk.com/job/v654044
Employer: King's College Hospital
Location: London, England
Sector: Academia
Degree required: Certified Neuropathologist
Conditions: NDG
Job posted: March 4th, 2017
Applications close: February 4th, 2017
King's College HospitalLondon, EnglandCertified NeuropathologistNDGMar 04, 2017
Postdoctoral Fellow, Storkebaum Lab

Postdoctoral Fellow, Storkebaum Lab

(Click title to open job details in a new window.)
Description:

We combine Drosophila and mouse genetics to study the molecular pathogenesis of the neurodegenerative disorders Charcot-Marie-Tooth neuropathy (CMT) and amyotrophic lateral sclerosis (ALS). The project that is offered will focus on the molecular mechanisms underlying CMT associated with mutations in tRNA synthetases, and is based on our recent publications in this field. Using Drosophila models for these diseases, we have identified a detailed molecular mechanism underlying the protein translation defect in motor and sensory neurons in vivo (unpublished). The proposed project involves the validation of this mechanism in mouse models, the most disease-relevant mammalian models currently available for these genetic disorders. If desired, the successful applicant could combine these studies with Drosophila genetic approaches. On the longer run, the development of an independent project that can be transferred to a future position is possible.


A broad spectrum of methods will be applied, all of which are well established in our lab, including mouse genetics, the recently developed FUNCAT technique, immunohistochemistry, several imaging techniques, molecular biology, protein biochemistry, and possibly also Drosophila genetics.


For further information please visit the Storkebaum lab website:

http://www.mpi-muenster.mpg.de/22108/storkebaum


Please send your application (with the position-code 02-2017), including motivation letter (up to one page), CV and the names of 2 referees via email to:


career@mpi-muenster.mpg.de


Max Planck Institute for Molecular Biomedicine

Roentgenstrasse 20

48149 Muenster

Germany


Link: http://www.nature.com/naturejobs/science/jobs/607393-postdoctoral-scientist
Employer: Max Planck for Molecular Biomedicine
Location: Münster, Germany
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: March 2nd, 2017
Applications close: March 19th, 2017
Max Planck for Molecular BiomedicineMünster, GermanyPhDALSMar 02, 2017
Postdoctoral Fellow, Xia Lab

Postdoctoral Fellow, Xia Lab

(Click title to open job details in a new window.)
Description:

A group of established investigators recently join the University of Central Florida (UCF) Medical College to form a competitive research team studying the mechanisms of neurodegeneration in amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). The team uses genetically engineered rats as a relevant model for the in vivo study of neurodegeneration associated with genetic mutations discovered by the team and by the other groups. Team members have documented findings in the journals including PLoS Genetics (2010 and 2011), the Journal of Clinical Investigation (2012), EMBO J (2013), PNAS (2013), and Acta Neuropath (2015). The team is funded by multiple NIH grants and has received supports from the UCF. The team invites experienced persons to join as a key member in the journey of discovery on disease mechanisms and therapies.


Post-doctors: Post-doctoral positions are immediately available to candidates who have experienced one or more of the following research activities: 1) characterizing transgenic or knockout mouse or rat models for neurological diseases; 2) characterizing protein-protein interaction with biochemical and molecular approaches; 3) studying synaptic function with molecular and physiological approaches; and 4) studying autophagy or proteasome dysfunction in disease conditions. Publication in a related field is required.


The University of Central Florida is located in Orlando of the sunny state Florida. The medical school is quite new and is rapidly growing. Interested persons are sincerely invited to apply for the positions. Please send cover-letter and CV to Dr. Xugang Xia at xugang.xia@ucf.edu


UCF is an equal opportunity/affirmative action employer. All qualified applicants are encouraged to apply, including minorities, women, veterans and individuals with disabilities. As a Florida public university, UCF makes all application materials and selection procedures available to the public upon request.


Contact Us: xugang.xia@ucf.edu


Link: http://neurojobs.sfn.org/jobs/8848751/post-doctoral-position-available-immediately
Employer: University of Central Florida
Location: Orlando, FL
Sector: Academia
Degree required: PhD, MD, MD/PhD
Conditions: ALS, NDG
Job posted: March 2nd, 2017
University of Central FloridaOrlando, FLPhD, MD, MD/PhDALS, NDGMar 02, 2017

Industry

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Associate Director or Senior Manager, Business Development and Alliance Management

Associate Director or Senior Manager, Business Development and Alliance Management

(Click title to open job details in a new window.)
Description:

In conjunction with and reporting to the Sr. Vice President of Business Development, the Senior Manager/Associate Director, Business Development and Alliance Management will focus on building value through strategic alliances and/or licensing transactions.


The responsibilities for this position involve serving as a cross-functional leader working in close coordination with key senior staff and consultants (e.g., within Commercial Development, Intellectual Property and Legal Affairs, Finance, Project Management and R&D) and engaging with our partners and potential partners at all levels.


This individual will:


Serve as a key contact for existing partners and on the team responsible for identifying, evaluating, negotiating, and executing new strategic alliances and/or licensing transactions.

Participate in Cytokinetics’ strategic planning process.

Develop and maintain strong internal and external relationships to facilitate effective execution of business development campaigns, including due diligence, terms development and negotiation.

Ensure effective partnership governance and planning.

Provide guidance to others working on Cytokinetics’ partnerships and lead initiatives to enhance business development and alliance management capabilities.


Qualifications:


A minimum of 7 years of post-baccalaureate experience in the biotechnology/pharmaceutical industry is required. Based on years of relevant experience, candidates at the Manager level may be considered.

Advanced degree (e.g., M.B.A., J.D., Ph.D., etc.) with a relevant technical degree.

Track record of productive participation in a business development or alliance management role.

Experience with negotiating and/or managing contractual relationships, including firm understanding of IP/licensing fundamentals.

Excellent analytical capabilities, strong interpersonal and communication skills, demonstrated creativity, flexibility and problem-solving ability, solid knowledge base regarding business development and alliance management practices and trends, and proven ability to work effectively in a team environment with interactions across multiple, diverse disciplines


Link: https://cytokinetics.com/company/careers/job-opportunities/
Employer: Cytokinetics
Location: San Francisco, CA
Sector: Industry
Degree required: PhD, MBA or JD
Conditions: ALS
Job posted: April 18th, 2017
CytokineticsSan Francisco, CAPhD, MBA or JDALSApr 18, 2017
NEW! Clinical Research Fellow, Neuromuscular Diseases

Clinical Research Fellow, Neuromuscular Diseases

(Click title to open job details in a new window.)
Description:

We now offer a unique opportunity to an academic clinical neurologist to join our team as a Clinical Research Fellow in Neuromuscular Diseases. During a negotiable 1-2 year commitment based at Cytokinetics’ offices in South San Francisco, the Fellow will contribute invaluable expertise to our clinical development programs in neuromuscular diseases. The Fellow will benefit from an experience rarely available in a strictly academic position; i.e., the day-to-day leadership and management of a clinical trial aimed at the development of new therapeutics for patients. The Fellow may engage in this opportunity in the context of their academic fellowship as a means to satisfy a research requirement if agreeable to their institution. Continued involvement in the clinical management of patients during the period of this fellowship will be encouraged. The Fellow may return to his or her academic post at the conclusion of the term, enriched by this experience in addition to returning to the parent institution with a portfolio of valuable clinical research competencies.

The Fellow will report to the Clinical Director of Neuromuscular Therapeutics at Cytokinetics. Compensation will be at industry-competitive standards commensurate with experience and a benefit package can be provided. In participating in clinical trials, the Fellow will also participate in our collaboration with Astellas as a member of the Project Team, clinical advisory board management; protocol design; clinical trial site recruitment, initiation, and monitoring; and data interpretation and reporting.


Responsibilities:

Serve as a primary source of neuromuscular expertise for the study management team, clinical project team, and other internal and external stakeholders as required.

Provide input to decisions that have medical, scientific, and future marketing implications for Cytokinetics’ investigational new drugs that may eventually treat a broad array of neuromuscular diseases.

Contribute to the design, planning, initiation and completion of clinical trials in neuromuscular diseases.

Liaise with scientists within and outside of Cytokinetics to inform our basic and translational research on skeletal muscle activators.

Author the medical components of key documents, including study protocols and related regulatory submissions.

Manage communications and relationships with other prominent clinical investigators and thought leaders in neuromuscular diseases.

Represent Cytokinetics at scientific and patient-focused meetings related to neuromuscular diseases.

Help to implement Cytokinetics’ clinical development strategies during interactions with regulatory authorities such as FDA and EMA.

Monitor and interpret the accumulating clinical safety data for Cytokinetics’ investigational new drugs.


Qualifications:


MD, MD/PhD, or DO degree with neurology board certification or eligibility by the American Board of Psychiatry and Neurology

Experience in the management of patients with SMA is desired; experience with clinical trials of therapeutics intended for the treatment of SMA or other neuromuscular diseases and expertise in muscle physiology and nerve cell function would be a critical advantage

Excellent written and verbal communication and presentation skills

Strong interpersonal and leadership skills

Ability to work within a multidisciplinary team


Link: https://cytokinetics.com/company/careers/job-opportunities/
Employer: Cytokinetics
Location: San Francisco, CA
Sector: Industry
Degree required: MD, MD/PhD, or DO
Conditions: ALS
Job posted: April 18th, 2017
CytokineticsSan Francisco, CAMD, MD/PhD, or DOALSApr 18, 2017
NEW! Director, Clinical Pharmacology

Director, Clinical Pharmacology

(Click title to open job details in a new window.)
Description:

Reporting to the EVP Research & Development, the Director, Clinical Pharmacology will be responsible principally for early clinical drug development activities with a strong focus on Phase I and Phase IIa clinical trials. He/She will work closely with the Clinical Research Group and other members of the R&D team to ensure a strategic view is taken for the pipeline progression of individual projects.


Responsibilities:

Design Phase I and Phase IIa clinical studies, including dose escalation, stopping rules and risk-benefit to ascertain that compounds are entered into man safely, efficiently and with scientific validity.

Responsible for the medical content of clinical pharmacology studies.

Responsible for the medical aspects of clinical pharmacology components related to regulatory documents and interact with regulatory authorities for all phases of drug development.

Medical monitor in sponsored studies as appropriate, ensure that the clinical teams correctly handle all adverse events (AEs) and serious adverse events (SAEs) in accordance with ICH standards.

Correctly apply the ICH and GCP regulations surrounding the primary activities of clinical development projects.

Operate within the time and budget constraints of the clinical program.

In collaboration with the Chief Medical Officer, train members of the product development team to enhance their skills.

Communicate project-related information, including the planning and execution of meetings and presentations.

Coordinate and complete scientific documents including protocols, clinical study reports, other regulatory documents.

Travel up to 30% as necessary according to project needs.


Qualifications:

Registered Medical Doctor (mandatory qualification).

Board certification/specialist registration in clinical pharmacology highly desirable or significant prior relevant experience

PhD in clinical pharmacology would be an asset.

At least 5 years of experience in drug development in the pharmaceutical and/or biotech industry, covering both early and translational phase development or significant participation in industry sponsored research as a clinical investigator.

Randomized controlled clinical trial principles, methodology and procedures.

Adverse medical event investigation, analysis, as well as reporting procedures and standards.

FDA and EMA regulatory requirements and ICH/GCP guidelines is an asset.

Federal and state regulations and guidelines pertaining to the conduct of clinical trials on human subjects.

Statistical data collection, editing, validation and analysis techniques.

Current and developing trends and standards in clinical trials monitoring.

Industrial standards as applied to GCP and GLP.

Infrastructure and operational characteristics of Contract Research Organizations (CROs) and centralized clinical laboratories.

Ability to develop and implement clinical research monitoring plans and study specific procedures.

Ability to establish data collection and management guidelines.

Ability to communicate, interact and present competently and professionally both verbally and in writing at all levels within a broad, complex clinical research environment including third parties such as CRO’s and academia.


Link: https://cytokinetics.com/company/careers/job-opportunities/
Employer: Cytokinetics
Location: San Francisco, CA
Sector: Industry
Degree required: MD
Conditions: ALS
Job posted: April 18th, 2017
CytokineticsSan Francisco, CAMDALSApr 18, 2017
Scientist, Neuroscience

Scientist, Neuroscience

(Click title to open job details in a new window.)
Description:

Genentech is inviting applications for a Scientist position (rank equivalent to assistant professor in academia) in the Department of Neuroscience. We are seeking an exceptional, highly motivated and creative scientist to lead innovative research efforts focused on unraveling the mechanisms of neurodevelopment and/or brain function in the context of nervous system diseases. He/she will also be expected to participate in inter-disciplinary teams to identify novel drug targets and discover new drugs to treat nervous system disorders. The ideal candidate will have significant experience in molecular and cellular biology using both in vitro and in vivo model systems, and possess a deep mechanistic understanding of the cellular pathways that contribute to diseases of the nervous system (e.g. neurodegenerative diseases). A solid track record of publications in top tier journals is required as is exceptional communication skills. The position will involve close collaboration with other research labs in Neuroscience as well as investigators in areas such as human genetics, bioinformatics, proteomics, imaging, and small molecule and large molecule drug discovery. The successful candidate will be expected to publish their research in high quality journals.


As a strong candidate, you will have:

PhD with postdoctoral research experience in cell biology, neuroscience or related areas in life sciences.

Record of impactful research in molecular cellular biology, neuroscience, or related fields, as evidenced by recent first authored publications in top-tier journals.

Excellent written and oral communication skills

The drive and ability to lead an independent research group and collaborate with other investigators

Outstanding promise of future scientific achievement


Link: https://www.gene.com/careers/detail/3398510619/Scientist-Neuroscience-Genentech-Research
Employer: Genentech
Location: San Francisco, CA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: April 6th, 2017
GenentechSan Francisco, CAPhDNDGApr 06, 2017
Research Scientist

Research Scientist

(Click title to open job details in a new window.)
Description:

We are looking for an experienced BS or MS degreed research scientist to join the Neuroscience department. The candidate will play a hands-on role in a highly collaborative team responsible for research on neurodegenerative diseases. You will conceive, conduct, and analyze experiments to identify and evaluate compounds or biologics in various assays and cellular models. These include but are not limited to bioanalytical and biochemical assays, human ES/iPS derived neuronal models, and analysis of tissue samples.


The candidate will have a B.S. or M.S. degree or equivalent in biochemistry, cell biology, neurobiology or a similar discipline with 6-12 years of research experience. Previous experience in industry and/or with neurodegenerative diseases is a plus. The candidate must be highly collaborative, self-motivated, team-oriented, and have excellent communication and computer skills.

A variety of laboratory techniques will be used to rapidly progress therapeutic ideas from concept to results. Expertise in some of the areas listed below is required, but we also expect that candidate will develop new skills as needed to address the emerging biological questions.


•Protein biochemical analysis of cell lysates and mouse and human tissue.

•High-throughput cellular and biochemical assay development, and familiarity with analysis of large data sets including high-content imaging data.

•General cellular and molecular laboratory techniques such as cloning, lentiviral production, and flow cytometry.

•Conventional cell culture, cell line engineering, and cell-based assay development. Experience in pluripotent stem cell culture, differentiation, and CRISPR/CAS9 genome engineering is a plus.


Link: https://sjobs.brassring.com/TGWEbHost/jobdetails.aspx?partnerid=13617&siteid=5268&Areq=209999BR&codes=13335
Employer: Novartis
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: March 31st, 2017
NovartisCambridge, MABS or MSNDGMar 31, 2017
Senior Associate Scientist

Senior Associate Scientist

(Click title to open job details in a new window.)
Description:

Position Overview:


Yumanity is seeking a talented and versatile BS/MS scientist to join our interdisciplinary team to help advance novel drug discovery programs for neurodegenerative diseases. This position will be laboratory based, and requires strong experimental skills with background in cell and molecular biology and experience in quantitative assay development. The successful candidate must be highly flexible and team-oriented. The position will report to a Principal Scientist in the Mammalian Assay Development group, and will interact across all of Yumanity’s core platforms, including yeast phenotypic screening, target identification, stem cells and chemistry.


Responsibilities include:


*Assist in developing neurodegenerative disease models in mammalian cells; including cell lines, rodent primary neurons and iPS cell-derived neurons.

*Assist in developing assays to validate the activity and targets of small molecules identified from yeast phenotypic screening and target identification activities.

*Directly interact and collaborate with the medicinal chemistry team to evaluate identified and novel small molecule activity and properties.

*Generate and maintain embryonic rodent primary neurons to assist with development of neurodegenerative disease models and assays.

*Analyze and interpret experimental data, address methodological challenges in experimental protocols and clearly convey results to the team in oral and written fashion.

*Maintain accurate and up to date documentation of all laboratory activities (notebooks, databases).

*Independently operate and oversee maintenance of selected lab equipment.

*Consult scientific literature as needed.


Experience and skills required:


*A Bachelor’s (+5 yrs experience) or Master’s (+3 yrs experience) degree in biology or related discipline.

*Proficiency in basic lab techniques (Mammalian cell culture, ELISA, Western Blot, rtPCR) and principles of cell biology, biochemistry or molecular biology required.

*Proficiency in rodent embryonic brain dissection and harvesting primary neurons techniques is highly desirable.

*Experience in assay development.

*Knowledge of relevant scientific databases is preferred.


Link: http://www.yumanity.com/careers/
Employer: Yumanity Therapeutics
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: March 30th, 2017
Yumanity TherapeuticsCambridge, MABS or MSNDGMar 30, 2017
Senior Associate Scientist

Senior Associate Scientist

(Click title to open job details in a new window.)
Description:

We are seeking a Research Senior Associate Scientist to join a vibrant and growing group currently focusing on Neurodegenerative diseases within the Neuroscience Therapeutic Area, a key component of the Discovery Research unit at Amgen’s site in Cambridge, MA (Amgen MAssachusetts-AMA). The successful candidate must be highly motivated with a deep interest in developing new and effective therapeutics for Parkinson’s disease (PD)/ALS.


Position Responsibilities

*Conduct biochemical and cell-based experiments/assays to evaluate novel mechanisms and interrogate the biology of new therapeutic targets for PD/ALS

*Carry out experiments required to rigorously evaluate in-licensing opportunities

*Critically analyze and interpret data, and meet delivery deadlines

*Work closely with and communicate results to multi-disciplinary and cross-functional teams

*Execute high impact studies within an extremely fast-paced and collaborative environment


Preferred Qualifications

*Master’s Degree in Neuroscience

3+ years of experience in neuroscience and neurodegenerative diseases

*Experience/expertise in culturing primary neurons, iPSC-derived neurons and immortalized cell lines

*Experience with CRISPR and iPSC technology

*Experience developing a wide range of cell-based assays, and in interrogating a variety of cellular signaling pathways

*A high degree of computer literacy and excellent analytical/problem-solving skills

*Good organizational skills with the ability to independently design and execute experiments, and interpret results

*Outstanding interpersonal and communication skills, and superior multi-tasking abilities

*Highly motivated and adaptable individual who enjoys working in a team environment and welcomes new challenges.


Link: https://amgen.wd1.myworkdayjobs.com/en-US/Careers/job/US---Massachusetts----Cambridge/Sr-Associate-Scientist---Parkinson-s-Disease---ALS_R-36298
Employer: Amgen
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: ALS
Job posted: March 28th, 2017
AmgenCambridge, MABS or MSALSMar 28, 2017
Senior Scientist, Neuroinflammation

Senior Scientist, Neuroinflammation

(Click title to open job details in a new window.)
Description:

The Merck Early Discovery Neuroscience team is seeking a highly motivated and technically skilled neuroscientist with a strong background in neuroimmunology to join our Boston-based early drug discovery team. Position is for a lab-based biologist who will generally be responsible for supporting the identification and validation of novel targets. The primary responsibilies will include the design and execution of both in vitro experiments and in vivo studies – applying biochemical, cellular/molecular, histological and imaging techniques – to drive toward a deeper understanding of disease pathogenesis, establish novel models thereof, and enable mechanism of action assessments for candidate therapeutics. The Senior Scientist will be an active participant in the critical scientific dialogue that supports our mission of early discovery in support of the Merck Neuroscience pipeline.


The responsibilities of the Senior Scientist include:


– Characterize the complex interplay between neurons, glial cells and disease pathogenesis in animals models of neurodegeneration.

– Collaborate to develop disease relevant cellular models using primary neurons and glia.

– Analyze, summarize and communicate data clearly and concisely to teams and stakeholders.

– Monitor, review and critically interpret published work to guide internal research.

– Collaborate with members across diverse functional areas, including but limited to colleagues from genetics, medicinal chemistry, in vivo and in vitro pharmacology, chemical biology and translational sciences.

– Work with external academic, biotechnology, and contract research organizations


Link: http://jobs.sciencecareers.org/job/443381/senior-scientist-neuroinflammation-boston-job/
Employer: Merck
Location: Boston, MA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: March 24th, 2017
MerckBoston, MAPhDNDGMar 24, 2017
Research Associate

Research Associate

(Click title to open job details in a new window.)
Description:

Nuredis, Inc. discovers and develops small molecule therapies for a group of inherited neurodegenerative and neuromuscular diseases, aiming to treat the cause of disease rather than just managing symptoms. Nuredis was founded in 2016 based on technology licensed from Stanford, with facilities in Menlo Park. We are currently seeking self-driven, intelligent individuals to add their complementary talents to our highly-motivated team.


Purpose


Nuredis seeks a qualified candidate to fill the position of Research Associate. This person will perform basic functions and research activities to contribute to development of therapeutic agents. Duties will include conducting and analyzing experiments under the supervision of Scientists, as well as managing lab equipment, records, and supplies.


Minimum Qualifications


B.S. OR M.S. in Biology, Biochemistry, Molecular Biology, Neurobiology or related field, plus at least two years of laboratory experience

Comprehensive understanding of molecular and cell biology principles

Strong interpersonal skills and ability to work in a team with many different researchers

Computer literacy in Microsoft Office (Word, Excel, and PowerPoint)


A qualified candidate will have experience and/or relevant education in the following areas:


*Nucleic acid and protein handling, including isolation of these molecules from cell or tissue samples, RT-PCR, Western blotting, etc.

*Tissue culture, with the following duties: thaw, grow, passage, count, analyze and freeze cell lines of diverse types from multiple sources; monitor cultures for contamination; use and maintain the cell line record database; experience with iPSC lines is a plus

*Lentiviral transduction of cultured cells, with demonstrated knowledge of the appropriate BSL-II safety requirements (training, technique, proper Personal Protection Equipment) for safe handling of viruses

*Plan and perform experiments with minimal supervision, using reasonable personal judgment and knowledge of basic laboratory techniques and protocols; in collaboration with supervisors and colleagues, contribute to analysis and interpretation of results and data; and use experience and observations to optimize protocols and assays

*Maintain timely and detailed records of experiments, results and analysis

*Review current literature to remain knowledgeable of new procedures and related research

*Contribute to publications and presentations, as appropriate

*General lab maintenance and support; share tasks with other members of the lab that may include maintaining stock reagents, managing chemical and reagents inventories, maintaining safety and other lab documentation, managing inventory, and ordering of lab supplies and reagents


To apply, please email your cover letter and resume to HR(at)nuredis(dot)com, with the subject line “Nuredis Application: Research Associate.”


Link: https://www.indeed.com/cmp/Nuredis,-Inc./jobs/Research-Associate-3c0216c1dd418032
Employer: Nuredis
Location: Menlo Park, CA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: March 23rd, 2017
NuredisMenlo Park, CABS or MSNDGMar 23, 2017
Associate Scientist III, Neuroimmunology

Associate Scientist III, Neuroimmunology

(Click title to open job details in a new window.)
Description:

The Biogen Department of Neuro/Immunology seeks a highly motivated and keen associate scientist whose primary responsibility is to advance target validation, drug discovery and development. The individual is expected to have mastered a broad range of experimental techniques, preferably having established expertise in the field of neuroimmunology. The individual will be expected to perform with significant independence with respect to designing and executing controlled experiments, analyzing and interpreting results, establishing and executing existing or new protocols/methodologies and recommending modifications. The individual is expected to read pertinent literature and exhibit knowledge of molecular and biological processes, applying their knowledge to propose new ideas and regularly make suggestions for creative solutions to technical challenges. The individual is expected to have strong written and verbal communication skills, preparing and delivering oral presentations, posters, draft research reports and contributing to manuscripts.


Responsibilities include:


•Driving target validation efforts for neurodegenerative diseases such as Alzheimer’s, Parkinson’s and ALS, with a particular focus on glial cells and neuroinflammation.


•Using a wide array of techniques relevant to neuroimmunology and glial cells


•Leveraging animal models of neuroinflammation and neurodegeneration to demonstrate proof-of-biology; knowledge and experience with such models is preferred.


•Designing and executing experimental plans, performing rigorous analysis and interpretation of experiments.


•Collaborating with relevant individuals and groups to advance projects; demonstrating good lab citizenship.


• Skilled experimentation encompassing a wide array of in vitro and in vivo techniques; relatively independent design, execution, analysis and interpretation of experiments.


• Strong oral and written presentation of technical work


• Collaboration with relevant individuals and groups to advance projects; demonstration of good lab citizenship.


Link: https://jobs.biogen.com/job/Cambridge-Associate-Scientist-II%2C-Research-MA-02138/376780100/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: ALS
Job posted: March 17th, 2017
BiogenCambridge, MABS or MSALSMar 17, 2017
Senior Associate Scientist, Neuroimmunology

Senior Associate Scientist, Neuroimmunology

(Click title to open job details in a new window.)
Description:

The Neuroimmunology department at Biogen is searching for a committed, enthusiastic and dependable associate scientist to assist with the design, execution and interpretation of preclinical studies for drug discovery and development. The incumbent will be part of a multifunctional team with responsibility for target validation and evaluation of novel drug candidates for neurodegenerative/neuroinflammatory diseases. He/she should be able to plan and execute in vivo and in vitro experiments with high level of independency, organization and scientific rigor. He/she should be able to maintain an up-to-date knowledge of pertinent literature and possess excellent communication and interpersonal skills to efficiently present results to project team members.


Link: https://jobs.biogen.com/job/Cambridge-Associate-Scientist-II%2C-Research-MA-02138/371072000/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: March 15th, 2017
BiogenCambridge, MABS or MSNDGMar 15, 2017
Principal Investigator, Laboratory of Neuronal Cell Biology

Principal Investigator, Laboratory of Neuronal Cell Biology

(Click title to open job details in a new window.)
Description:

As Principal Investigator for the Laboratory of Neuronal Cell Biology (LNCB), he or she will be:


•Responsible for converting new science into new targets, drug discovery programs, and technology programs for the Biogen portfolio with an emphasis on neurological disease.


•Accountable for building and advancing new neurobiology within a group of dedicated postdoctoral fellows and technicians.


•Contributes to developing and executing research strategies to deliver against Biogen’s objectives to engage in quality science that leads to a deeper understanding of targets and enables the research imperative of “choose the right targets”.


•Supports the Head of R&D (who also serves as Director for the LNCB) in defining basic and applied biology, molecular pharmacology, cellular biology, and in vivo neurobiological programs that augment the Biogen portfolio.


•Manages the day-to-day operations of the LNCB providing support and direction to the postdoctoral fellows and technician(s) in the lab.


•Accountable for people agenda in the LNCB including colleague development, reward and recognition, recruitment and retention, and communication.


•Builds external recognition for team through high impact publications.


ROLE RESPONSIBILITIES


• Single point of accountability for the functioning and delivery of the LNCB for projects assigned to his/her team. Able to ensure the lab can optimally utilize the resources available.


• Models expectations of quality, innovative science applied to discovering new medicines, and of effective people leadership and talent development.


• Builds cross-functional projects that cut across disciplines, including chemical biology, molecular and cell biology, cellular screening, and in vivo pharmacology.


• Engages the external environment through thought leadership and visible and active engagement with key opinion leaders, funding bodies, professional societies, and academic institutions and publishing of scientific work


• Partners with Biogen research leaders in the development of key talent within and across the Biogen laboratories.


• Able to effectively identify and advance breakthrough science.


• Consistently converts new science into new targets, drug discovery programs, and technology platforms for the Biogen portfolio.


• Able to maximize the value from an academic-style lab group in the midst of the discovery organization, aligned with therapeutic interests, but empowered to explore new biology through access to technologies and collaborations with existing groups.


• Works closely with individuals across Biogen Research Laboratories


• Manage, create, and leverage technologies to prosecute state-of-the-art research on novel pathways and targets.


• Effectively communicate proposed and completed research through presentations and publications both internally and externally.


• Lead and support research platforms in primary neuron culture, brain slices preparations, and in vivo rodent models.


• Connects LNCB science to Biogen platforms in structural biology, medicinal chemistry, screening, genetics, computational modeling, bioinformatics, veterinary sciences, pharmacokinetics/metabolism, and protein engineering.


• Ensure team access to reagents, data analysis, and technical resources across Biogen Research.


• Drives scientific excellence on projects that transform drug discovery efforts in the Biogen portfolio; ensures high impact publications.


• In addition to responsibilities over the LNCB, the Sr. Scientist will be responsible for building target class platforms that support discovery programs across the Biogen portfolio and particularly for neurodegenerative diseases. Target class platforms refer to broad classes of receptors, enzymes, or related macromolecules for which all necessary reagents, assays, screening systems, quantitative read-outs, and in vivo models are elaborated in a highly scaled and industrialized fashion. Examples include GPCRs, serine hydrolases, transporters, etc.


• The Sr. Scientist will further assume broad responsibility for new target identification that supports new programs that enter in the Biogen portfolio, and contributes to a sustainable pipeline of first-in-class programs. New targets will be rooted firmly in human biology and human genetics, and he/she will leverage ongoing work by postdoctoral fellows and others within the LNCB to provide 10-15% of the new targets pursued by Biogen.


Link: https://jobs.biogen.com/job/Cambridge-Sr-Scientist%2C-Laboratory-of-Neuronal-Cell-Biology%2C-Research-MA-02138/347661800/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD or MD/PhD
Conditions: NDG
Job posted: March 9th, 2017
BiogenCambridge, MAPhD or MD/PhDNDGMar 09, 2017
Scientist I/II, Translational Sciences

Scientist I/II, Translational Sciences

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Description:

The Biogen Department of Neuro/Immunology seeks a highly motivated and keen associate scientist whose primary responsibility is to advance target validation, drug discovery and development. The individual is expected to have mastered a broad range of experimental techniques, preferably having established expertise in the field of neuroimmunology. The individual will be expected to perform with significant independence with respect to designing and executing controlled experiments, analyzing and interpreting results, establishing and executing existing or new protocols/methodologies and recommending modifications. The individual is expected to read pertinent literature and exhibit knowledge of molecular and biological processes, applying their knowledge to propose new ideas and regularly make suggestions for creative solutions to technical challenges. The individual is expected to have strong written and verbal communication skills, preparing and delivering oral presentations, posters, draft research reports and contributing to manuscripts.


Link: https://jobs.biogen.com/job/Cambridge-Scientsit-III%2C-Translational-Sciences-MA-02138/384302200/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: March 9th, 2017
BiogenCambridge, MABS or MSNDGMar 09, 2017
Director/Senior Director of Neurodegeneration and Repair Research

Director/Senior Director of Neurodegeneration and Repair Research

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Description:

We are looking for a talented leader to direct preclinical research in Dementia and Memory Disorders within the new Neurodegeneration and Repair Research Unit. In close partnership with the early clinical lead for within the same unit, the successful candidate will be responsible for delivering innovative drug candidates for proof-of-concept trials in AD, FTD and other memory disorders. He/she will lead the efforts of multiple research teams from early target discovery to late preclinical development and support the clinical trial strategy. We seek a candidate with knowledge of the biology of neurodegeneration and an outstanding track record in the field of drug development. He/she will succeed by collaborating closely with other Biogen scientists and clinicians in the areas of neurodegeneration, neuroimmunology and repair, as well as experts in the multiple therapeutic modalities – small molecules, antibodies, biologics, antisense oligonucleotides and gene therapy – in the Biogen portfolio. An innovative approach to biomarker and drug delivery strategies will also be required. We particularly seek candidates who have demonstrated strong scientific rigor while exploring novel pathways and mechanisms in humans and model systems and in leading multidisciplinary research teams. Demonstrated expertise in Alzheimer’s research and experimental models would be an advantage but is not required.


Link: https://jobs.biogen.com/job/Cambridge-DirectorSr_Director%2C-Neurodegeneration-and-Repair-Research-MA-02138/374546100/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD or PhD/MD
Conditions: FTD
Job posted: March 5th, 2017
BiogenCambridge, MAPhD or PhD/MDFTDMar 05, 2017

Non-Profit and Government

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
Research Assistant I/II, Lutz Group

Research Assistant I/II, Lutz Group

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Description:

The group of Dr. Cathleen Lutz has openings for full-time positions at the Research Assistant level. Our group focusses on the development and characterization of mouse models for human diseases, with an emphasis on optimal use and best practices for research and preclinical drug development. The laboratory works with the NIH, disease foundations and the pharmaceutical industry to improve on existing mouse models and generate new ones, identify modifier genes, and develop assays that facilitate therapeutic development. Our overarching goal is to work with the scientific community to facilitate the rapid characterization, standardization and consistent use of mouse models, with the aim of accelerating treatment discovery. Current projects are focused on Spinal Muscular Atrophy, Friedreich’s Ataxia, Amyotrophic Lateral Sclerosis, Duchenne Muscular Dystrophy and Rett Syndrome.


This position will involve performing general laboratory routine procedures such as laboratory maintenance, mouse colony husbandry and genotyping, samples collection, clinical evaluation, molecular biology and biochemistry (e.g. PCR, western and southern blotting, RNA analyses), and operating, after training, advanced phenotyping tools such as metabolic cages, electrophysiology recorders, etc.


A cover letter outlining general interests and career goals should be submitted with Resume as one document to consider application complete.


Link: https://jax.silkroad.com/epostings/index.cfm?fuseaction=app.dspjob&jobid=220728&company_id=15987&version=2&jobBoardId=3345
Employer: The Jackson Laboratory
Location: Bar Harbor, ME
Sector: Non-Profit
Degree required: BA or BS
Conditions: ALS
Job posted: April 8th, 2017
The Jackson LaboratoryBar Harbor, MEBA or BSALSApr 08, 2017
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