Figure 3. Diffusion tensor imaging in the spinal cords of WT and cerebroside sulfotransferase knock-out (CST-KO) mice.
Image credit: Takano, et. al. 2012 under CC BY license

Job Opportunities

To submit any new job opportunities for this list, please email ALSjobs@prize4life.org. List the employer, location, closing date if applicable, and a link to more information. Jobs are removed after 3 months, unless requested otherwise.

This free job bulletin board aims to help scientists identify job opportunities in the field of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Positions described as broadly spanning neurodegenerative diseases (NDG) are noted as ‘NDG‘. The job listing includes research positions at all levels, as well as non-research positions for which a research background at the MS, PhD, or MD level is required.


Click the title of any table column to sort.

Academia

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Postdoctoral Fellow, Taylor Lab

Postdoctoral Fellow, Taylor Lab

(Click title to open job details in a new window.)
Description:

A postdoctoral position to study the molecular and cellular mechanisms of neurodegenerative disease, including amyotrophic lateral sclerosis and frontotemporal dementia, is available at the St. Jude Children’s Research Hospital in Memphis, TN, USA. We identified that many of neurodegenerative diseases are caused by defects in the assembly, disassembly, or clearance of cellular packages of RNA and proteins known as RNA granules. Our research focus is to investigate the role of RNA granules in regulating gene activity, explore how granules are assembled and disassembled, and investigate how these types of defects in RNA metabolism can cause neurodegenerative diseases.


Toward this end we:

*Use in vitro and in vivo modeling to elucidate the molecular basis of neuronal dysfunction and neuronal loss in neurological diseases

*Use the fruit fly Drosophila melanogaster to apply the power of genetics to illuminate the pathogenesis of neurodegeneration

*Investigate the molecular genetics of amyotrophic lateral sclerosis, frontotemporal dementia, inclusion body myopathy and polyglutamine disease

*Screen small molecules to identify compounds that can be translated to clinical use


Link: https://postdoc-stjude.icims.com/jobs/3041/postdoctoral-research-assoc/job?mode=job&iis=Job%2BPosting&iisn=LinkedIn&mobile=false&width=1180&height=500&bga=true&needsRedirect=false&jan1offset=-300&jun1offset=-240
Employer: St Jude Children's Research Hospital
Location: Memphis, TN
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: November 10th, 2017
St Jude Children's Research HospitalMemphis, TNPhDALS, FTDNov 10, 2017
NEW! Graduate Studentship, Ning and Ramesh Labs

Graduate Studentship, Ning and Ramesh Labs

(Click title to open job details in a new window.)
Description:

The cause of motor neuron (MN) degeneration is unknown in the majority of cases of ALS, although a number of pathogenic processes, including protein aggregation, mitochondrial dysfunction, oxidative stress, excitotoxicity and neurofilament dysfunction, are thought to play important roles in ALS. It has been reported that the capacity of the proteasome system to degrade proteins may be a limiting factor in the vulnerability of neurons to the degenerative process. Arfaptin-2, a downstream effector of ADP-ribosylation factors (ARFs), was identified as a novel protein as a target protein for GTP-ARFs and for GDP- Rac1. Humbert and colleagues showed that phosphorylation of Arfaptin-2 at Ser260 by Akt inhibits polyQ-huntingtin- induced toxicity by rescuing proteasome impairment (Rangone H et al, J Biol Chem 2005).

Our previous studies showed that Arfaptin 2 regulates the aggregation of mutant huntingtin protein and that a dominant inhibitory mutant of arfaptin 2 (HC-AIP2) inhibits aggregation of mutant huntingtin by activating and rescuing proteasome function (Peters PJ and Ning K et al, Nat Cell Biol, 2002). Our recent data also showed that overexpression of HC-AIP2 significantly increases cell survival in primary cultured SOD1 G93A motor neurons. Therefore, we hypothesize that arfaptin-2 plays a modulatory role in ALS and expression of a dominant inhibitory mutant of arfaptin-2 (HC-AIP2) would improve motor neuron survival via activation of proteasome activities in the sod1 and C9orf72 zebrafish model of ALS.


The Specific Aims Are


*To investigate expression and distribution of arfaptin-2 in control and ALS Brains;

*To assess whether depletion of arfaptin 2 affects disease pathogenesis in the sod1 and C9orf72 zebrafish model of ALS;

*To study the effects of HC-AIP2 on motor neuron survival and lifespan in models of ALS.


The outcome of the above specific aims would gain valuble evidence that arfaptin 2 is a therapeutic target for ALS. The next logical step is to devolop preclincal and clinical treatment of gene therapy for ALS patients.


This is a high profile project to investigate arfaptin 2 as a neuro-protective target for ALS. Apart from molecular and cell biology, the student will receive training on how to handle zebrafish and assess behavioural analysis, histological analysis of pathology. The work described here will be achieved in the state-of- the-art Translational Neuroscience Laboratory under the supervision of Dr. Ke Ning (primary supervisor, http://sitran.org/people/ning/ ) and Dr Tennore Ramesh (secondary supervisor, http://sitran.org/people/ramesh/ ).


Link: https://www.globalacademyjobs.com/jobdetails.aspx?id=68381&utm_source=attb
Employer: University of Sheffield
Location: Sheffield, England
Sector: Academia
Degree required: BS
Conditions: ALS
Job posted: November 9th, 2017
Applications close: January 24th, 2018
University of SheffieldSheffield, EnglandBSALSNov 09, 2017
NEW! Senior Research Project Manager

Senior Research Project Manager

(Click title to open job details in a new window.)
Description:

The IGM is seeking a Senior Research Project Manager interested in joining a group of Investigators using cutting edge genomic technology to study genetics with a primary focus on identifying and biologically characterizing genetic variation underlying human disease.


Responsibilities:

-Direct strategic and financial management activities within the scientific program areas, in particular

providing oversight and direction for studies of epilepsy, amyotrophic lateral sclerosis (ALS), reproductive genomics, schizophrenia, pediatric clinical sequencing, and other IGM precision medicine project areas;

-Advance the strategic planning and implementation of multiple research initiatives. Identify new

funding opportunities. Convene research strategy meetings; identify meeting participants, coordinate

meeting planning & oversee preparation of agendas/other meeting materials;

-Collaborate with the Pre-Award Core to coordinate development of complex proposals that may include

multiple PIs, depts., sites, labs, etc.

-Contribute scientific and research specific content to proposal narratives. Compile and edit proposal

narratives, incorporating original content and material supplied by others. Review and proof proposals;

-Manage the scientific progress of research grants held the Director and collaborative grants the Director is involved with. Develop time lines I milestones and work with collaborating sites to ensure timely submission of all required reports to Federal, collaborating sites and Foundation sponsors;

-Provide guidance on the development of project budget proposals in the Institute. Advise on budget/funding strategy;

-Work closely with IGM financial management staff on budget planning for grant submissions related to the Director or to large collaborative grants within the Institute;

-Ensure that funded projects for the Director of the IGM move forward. With DA and finance, ensure that funds are being spent correctly and effectively.

-Lead coordination of research activities at Columbia with the research activities at other collaborating universities and institutions within the consortiums or working group;

-Oversee efforts to prepare periodic and final reports to sponsors. Work collaboratively with finance to prepare financial portions of reports;

-Collaborate with the finance team and project leaders to coordinate the preliminary data and progress information for the completion of non-competing and competing reports and renewals for Director’s grants. Monitor subcontract expenditures related to the Director’s research to ensure appropriate use of funds are consistent with predefined milestones and scientific progress;

-With DA, ensure that intellectual property and other compliance-related concerns are addressed;

-Oversee implementation of agreements within IGM and act as ongoing point of administrative contact.

Project Management & Coordination

-With the IGM leadership, act as a key representative of the IGM within the research community, and serve as an administrative point person to faculty colleagues and researchers at other institutions. Help lead and support the IGM’s participation in collaborative initiatives, conferences, and colloquia. Organize research-related events hosted by IGM;

-Manage meetings of working groups and project leadership teams (such as Epi4K, Epi25 and e2 working groups, and epi SC monthly teleconferences);

-With the DA and Engagement Officer, provide administrative leadership for IGM’s communications activities, both internal and external. Working with School and institutional communications personnel, develop and implement Institute’s communications plan. This includes joint oversight of the website, mailing lists, and other digital and print communications channels;

-Other duties as required and assigned by the Director and/or DA.


Link: https://main.hercjobs.org/jobs/10463938/senior-research-project-manager
Employer: Columbia University
Location: New York, NY
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: November 9th, 2017
Columbia UniversityNew York, NYBA or BSALSNov 09, 2017
NEW! Senior Technician, Project ALS Preclinical Core Facility

Senior Technician, Project ALS Preclinical Core Facility

(Click title to open job details in a new window.)
Description:

An exciting opportunity for a motivated Senior Technician to join our new Project ALS Preclinical Core Facility at Columbia University Medical Center. The facility tests new treatment strategies and research drugs in mouse models of amyotrophic lateral sclerosis.


Duties will include behavioral monitoring of mice, IP/IV/SC injections, tissue dissection and immunohistochemistry. The incumbent will also be responsible for confocal microscopy, image analysis, statistical evaluation of results, as well as preparing solutions and performing other laboratory related duties necessary to the functioning of the core facility and research projects.


Link: https://main.hercjobs.org/jobs/10463931/senior-technician
Employer: Columbia University
Location: New York, NY
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: November 9th, 2017
Columbia UniversityNew York, NYBA or BSALSNov 09, 2017
NEW! Postdoctoral Fellow, Xia Lab

Postdoctoral Fellow, Xia Lab

(Click title to open job details in a new window.)
Description:

A research lab at the University of Central Florida Medical College invites you to apply for post-doctoral associate position. Research in the lab is focused on the genetic and molecular mechanisms of neurodegeneration in amyotrophic lateral sclerosis and Parkinson’s disease. Our team has published our findings in Acta Neuropath, EMBO J, the Journal of Clinical Investigation, PLoS Genetics, and PNAS. Post-doctors being recruited will help validate the pathogenic role of genetic mutations newly discovered in the lab using cell culture and animal models. The research lab is located at the UCF Burnett School of Biomedical Sciences at the Lake Nona campus. Researchers who have recently obtained their PhD degrees and seek to further develop their academic career are encouraged to apply for the positions. Please email your CV to Dr. Xugang Xia at xugang.xia@ucf.edu


Link: http://neurojobs.sfn.org/jobs/10457770/post-doctoral-associate
Employer: University of Central Florida
Location: Orlando, FL
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: November 8th, 2017
University of Central FloridaOrlando, FLPhDALSNov 08, 2017
Postdoctoral Fellow

Postdoctoral Fellow

(Click title to open job details in a new window.)
Description:

A postdoctoral position in “Molecular processes relevant for Amyotrophic Lateral Sclerosis (ALS) initiation and progression” will be available in the Center for Life Nanoscience at Istituto Italiano di Tecnologia (CLNS@SAPIENZA, Rome, Italy).


The Project Will Explore:

*The molecular circuitries controlling normal and pathological neuronal differentiation and activity.

*The molecular basis of neuromuscular diseases with specific interest in ALS pathogenesis.

*The pathogenic mechanisms of ALS-associated proteins involved in RNA metabolism.

*The role of long non coding RNAs (lncRNAs) and circular RNAs (circRNAs) in MN differentiation and in neuromuscular diseases with specific interest in the ALS pathology.

*The use of in vitro motor neuron differentiation from mouse Embryonic Stem Cells (mESC) and from human induced Pluripotent Stem Cells (iPS, from controls and ALS patients).

*The use of in vivo animal model systems for studying the activity of non coding RNAs with a relevant role in MN differentiation and function.

Candidates should have a PhD in Molecular Biology or Cell Biology or Biochemistry.


The position requires experience in some of the indicated subjects:

*Knowledge on basic mechanisms of gene expression control.

*Techniques of advanced molecular, biochemical, cellular and imaging methodologies for the study of cell differentiation.

*Characterization and function of non coding RNAs.

*Expertise on cell cultures and on manipulation of mESCs and human iPS.

*Computational skills for RNAseq data analysis


We value candidates with a proactive attitude and results-oriented mind-set, good interpersonal and communication skills and ability to work effectively within an interdisciplinary research team. An internationally competitive salary, dependent on experience, will be offered.

Interested applicants should submite their CV, list of publications, a statement of research interests, and names of two referees to katia.broccoletti@iit.it


Please quote “Molecular processes relevant for Amyotrophic Lateral Sclerosis (ALS) initiation and progression – BC 72946” as your application reference.


Please apply before: November 30, 2017.


Link: https://www.linkedin.com/jobs/view/500709463/
Employer: Istituto Italiano di Tecnologia
Location: Rome, Italy
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: November 4th, 2017
Applications close: November 30th, 2017
Istituto Italiano di TecnologiaRome, ItalyPhDALSNov 04, 2017
Research Associate

Research Associate

(Click title to open job details in a new window.)
Description:

The School of Health Sciences is seeking to appoint a Research Associate to work on an exciting collaborative MND Scotland and MND Association funded post. The aim of the project is to conduct repeated assessments of people living with Motor Neurone Disease (MND) over the course of the disease, to identify the impact and change of various factors (such as apathy, cognitive functioning and behaviour) in relation to everyday life and wellbeing of people living with MND and their families.


Part-time post (80%fte), available immediately on a fixed-term basis until 30th September 2019. The salary is £25,728 to £31,604 per annum (pro-rata)


You will work within a research team who will collectively undertake psychological, neuropsychological and functional assessments as well as semi structured interviews with patients and their families.


Applicants must hold a good degree in Psychology or a related field, and have good quantitative, administrative and organisational skills, and a flexible and conscientious approach. Sensitivity and professionalism in interacting with people with Motor Neurone Disease and their families is essential.


This post will be subject to a criminal record check from the Disclosure and Barring Service.


Closing date: 12 noon on 4th December 2017.


Further particulars and an application form are available on our website: www.uea.ac.uk/hr/vacancies or Tel. 01603 593493


Link: http://www.jobs.ac.uk/job/BFL179/research-associate-motor-neurone-disease/
Employer: University of East Anglia
Location: Norwich, England
Sector: Academia
Degree required: BS, Psychology
Conditions: ALS
Job posted: November 3rd, 2017
Applications close: December 4th, 2017
University of East AngliaNorwich, EnglandBS, PsychologyALSNov 03, 2017
Staff Associate, Pellizzoni Lab

Staff Associate, Pellizzoni Lab

(Click title to open job details in a new window.)
Description:

Columbia University’s Department of Pathology and Cell Biology has an immediate opening for a Staff Associate/Sr. Staff Associate position in Dr. Livio Pellizzoni’s lab.The incumbent will be responsible for carrying out fully planned experiments, in liaison with Postdoctoral Research Scientists/Fellows as well as PhD students, to study the molecular and cellular mechanisms of neurodegenerative disease in mouse models. The incumbent will use conventional biochemical, cellular, molecular, immuonohistochemical and behavioral assays. He/She will also maintain the mouse colonies, daily behavioral monitoring of mice, genotyping, ICV/IP injections, tissue dissection and immunohistochemistry. The incumbent will also be responsible for confocal microscopy, image analysis, statistical evaluation of results, as well as preparing solutions and performing other laboratory related duties necessary to the functioning of the research projects.


Link: https://main.hercjobs.org/jobs/10434039/staff-associate-senior-staff-associate
Employer: Columbia University
Location: New York, NY
Sector: Academia
Degree required: BA or BS
Conditions: ALS, SMA
Job posted: November 1st, 2017
Columbia UniversityNew York, NYBA or BSALS, SMANov 01, 2017
Postdoctoral Fellow, Verfaillie Lab

Postdoctoral Fellow, Verfaillie Lab

(Click title to open job details in a new window.)
Description:

The lab of Dr. Verfaillie at the Stem Cell Institute Leuven is looking for a postdoctoral fellow with expertise in: The lab of Dr. Verfaillie at the Stem Cell Institute at KU Leuven is recruiting an outstanding postdoctoral fellow highly versed in pluripotent stem cell biology techniques, including multicellular organoid cultures either in 2.5D and in 3D in suspension or in hydrogel based static or bioreactor cultures. The goal is to create lifelike small brain tissues, including the blood brain barrier or the cortex, that can be used as disease models in a dish, to study, Alzheimer’s, Parkinson, frontotemporal dementia or ALS available from teams at KU Leuven and the Flemish Institute of Technology (VIB), using patient iPSC and their isogenic counterparts. The technology should enable gaining superior insights in mature brain features such as defined connectivity and neuron-glia interactions, neurodegeneration phenotypes, and identification of druggable phenotypes.


The successful candidate will work in close collaboration with students/postdocs in the team highly experienced in creating different neuronal, glial and endothelial cells from iPSC, as well as with CRISPR/Cas technology and CRISPR/Cas genome screening approaches. In addition, investigators from IMEC will be supporting this effort by providing sensors for continuous monitoring of differentiating cells in 2D, as well as innovative artificial substrates and microfluidics devices for reproducible co-culture of different cell types and organoids.


Link: https://jobs.sciencecareers.org/job/469144/3d-coculture-organoid-cultures-of-brain-structures-from-neurodegenerative-disease-patient-ipscs/
Employer: KU Leuven
Location: Leuven, Belgium
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: October 31st, 2017
KU LeuvenLeuven, BelgiumPhDALS, FTDOct 31, 2017
Junior Group Leader

Junior Group Leader

(Click title to open job details in a new window.)
Description:

The Center for Psychiatry and Neurosciences of Paris-Descartes University and INSERM (https://cpn.paris5.inserm.fr/research/teams-and-projects) recently started its activities in a 4300 m² brand new building located in central Paris, ion the campus of Sainte-Anne Hospital. Ultimately, this new research center will host a total of 16 junior and senior teams devoted to integrated basic and clinical research. In addition to basic technical resources (cell culture, biochemistry and molecular biology equipment, etc…), research teams have access to technical core facilities for microscopy (confocal, spinning, SIM, STORM, STED), an animal house (10000 rodents capacity), electrophysiology and functional ultra sound imaging, and behavioural phenotyping. These resources are dedicated to interdisciplinary basic and clinical research in psychiatry and neurosciences. We are looking for junior principal investigators who are broadly interested in interdisciplinary neurosciences, including genetics and epigenetics, neurodevelopment, psychiatry, neuropsychopharmacology, computational neurosciences, brain tumours, aging and neurodegenerative diseases, brain imaging and neurovascular exploration, using approaches ranging from molecular and cellular biology to cognitive and translational neurosciences, including mathematics, image analysis and physics applied to neurosciences.


Appropriate office and laboratory spaces for up to 6 persons and a start-up package will be available. Successful candidates should hold a PhD and/or MD degree, have strong postdoctoral experience and meet criteria for to obtaining national (such as Atip-Avenir, ANR-JC, FRM Amorçage or other equivalent grants) and/or international funding (ERC StG), and for French institutional research positions (INSERM, CNRS). These positions are intended for first-time group leaders.


Applications (in English) should be sent to neuropsy2017@inserm.fr, and should include in one single pdf ‘applicantName_neuropsy2017.pdf’:


– a 1 page personal statement explaining why you are interested in joining our new Interdisciplinary Institute,


– a 4 page research plan for the next 5 years,


– a full CV (academic track, publications, patents, awards and fellowships, invited conferences, and teaching/training experience),


– contact details of 3/5 individuals who can be contacted for recommendation letters,


Deadline for applications is December 1st 2017. Short-listed candidates will be invited for interviews, to present their past achievements and research proposal in front of the international scientific advisory board (iSAB) and to visit our structure by the end of April 2018. Please address any question regarding the call to Dr Thierry Galli, CPN’s director: thierry.galli@inserm.fr.


Link: https://jobs.sciencecareers.org/job/469070/call-for-junior-group-leader/
Employer: Paris-Descartes University
Location: Paris, France
Sector: Academia
Degree required: PhD and/or MD
Conditions: NDG
Job posted: October 30th, 2017
Applications close: December 1st, 2017
Paris-Descartes UniversityParis, FrancePhD and/or MDNDGOct 30, 2017
Assistant or Associate Professor, Neuropathology

Assistant or Associate Professor, Neuropathology

(Click title to open job details in a new window.)
Description:

The Division of Neuropathology in Department of Pathology at Brigham and Women’s Hospital, a teaching affiliate of Harvard Medical School, is seeking an academically oriented, Board-certified Neuropathologist, at the Instructor, Assistant or Associate Professor level, with skills in surgical and autopsy neuropathology. Academic rank and salary will be commensurate with experience and accomplishments. Applicants should be committed to excellent patient care, as well as research, scholarship, and effective teaching. Experience or ability to participate in precision medicine and molecular pathology is preferred. Pathologists with academic focus in neurodegenerative, tumor, medical or any other areas of neuropathology expertise are encouraged to apply. The position will combine clinical duties and academic pursuits (research/teaching) and will be involved in the Longwood Neuropathology Training Program that includes the accredited fellowship program in adult and pediatric surgical and autopsy neuropathology at the Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Children’s Hospital Boston. Candidates would be expected to take advantage of the extensive resources and collaborative interactions within the Brain Tumor Research Program, the Ann Romney Center for Neurologic Diseases, and the Neuroscience Programs of the Harvard Medical School, Dana-Farber Cancer Institute, Brigham and Women’s Hospital, and The Children’s Hospital Boston. Applicants should also have the ability to lead or participate in research in an environment that provides substantial opportunities for clinical/ translational or basic research.


Please send curriculum vitae and names and addresses of three references to

Keith L. Ligon MD, PhD, Director of Neuropathology

c/o Mr. Terry Ott (NP Admin)

Brigham and Women’s Hospital

75 Francis Street

Boston, MA 02115

tott@bwh.harvard.edu


Link: https://www.nature.com/naturejobs/science/jobs/628093-brigham-and-women-s-hospital-academic-neuropathologist
Employer: Brigham and Women's Hospital
Location: Boston, MA
Sector: Academia
Degree required: Board-certified Neuropathologist
Conditions: NDG
Job posted: October 27th, 2017
Brigham and Women's HospitalBoston, MABoard-certified NeuropathologistNDGOct 27, 2017
Clinical Coordinator

Clinical Coordinator

(Click title to open job details in a new window.)
Description:

The Division of Neuromuscular Disorders is seeking a Research Support Coordinator to join a very active clinical research program with multiple ongoing research studies. The primary focus of the work will be on investigator-initiated research in the fields of amyotrophic lateral sclerosis (ALS) and myasthenia gravis (MG). The research support coordinator will work closely with clinical research coordinators, data manager, statistician, clinical staff and the principal investigator.


*Acquire an in-depth understanding of the research program and the details of specific research projects

*Assist with acquisition and maintenance of IRB approval for research studies as needed, including drafting protocol revisions, writing informed consent documents, developing and updating manual of procedures and case report forms

*Assist with recruitment and enrollment of study participants, coordination of study visits, and collection of study data

*Maintain accurate and complete source documents and case report forms; assist with data entry into research database

*Perform other duties as assigned by the PI.


The minimum qualifications for this position are as follows: Bachelor’s degree. Must be comfortable interacting with study participants and patients via telephone and in person. Excellent organizational as well as verbal and written communication skills are essential. Neuroscience experience is desired. Any appropriate combination of relevant education, certification(s) and/or work experience may be considered.


Link: https://um.hodesiq.com/job_detail.asp?JobID=5519513
Employer: University of Miami
Location: Miami, FL
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: October 27th, 2017
University of MiamiMiami, FLBA or BSALSOct 27, 2017
Assistant or Associate Professor, Neuroscience

Assistant or Associate Professor, Neuroscience

(Click title to open job details in a new window.)
Description:

The Albert Einstein College of Medicine (Einstein), together with the Montefiore Medical Center, has launched an ambitious Brain Sciences Initiative. As part of this large-scale expansion, the Dominick P. Purpura Department of Neuroscience has recruited a number of outstanding faculty, and will continue to recruit additional faculty in the coming years.


This year, candidates with research interests in all basic, clinical or translational disciplines of neuroscience will be considered for at least two tenure-track positions at the Assistant and Associate Professor level. Applications from exceptional Full Professors will also be considered. Outstanding applicants may be considered for named endowed Chair and endowed Scholar positions. There are also opportunities for co-appointments in clinical departments, particularly through the Psychiatry Research Institute at Montefiore/Einstein (PRIME) initiative, a new multidisciplinary psychiatric research center.


Applicants must have a PhD, MD, or equivalent degree, with a track record of research excellence. Qualified applicants should submit a cover letter, curriculum vitae, and a summary of research accomplishments and goals (maximum 3 pages) to neurosearch@einstein.yu.edu. Applicants should also arrange to have 3 letters of reference sent directly to this email address.


Link: https://jobs.sciencecareers.org/job/468668/assistant-or-associate-professor/
Employer: Albert Einstein College of Medicine
Location: New York, NY
Sector: Academia
Degree required: PhD or MD
Conditions: NDG
Job posted: October 26th, 2017
Albert Einstein College of MedicineNew York, NYPhD or MDNDGOct 26, 2017
Assistant, Associate or Full Professor, Neurobiology

Assistant, Associate or Full Professor, Neurobiology

(Click title to open job details in a new window.)
Description:

The BARROW NEUROLOGICAL INSTITUTE seeks an exceptionally promising or accomplished investigator to complement other translational neuroscience research in a unique and dynamic environment within the Division of Neurobiology at the Barrow Neurological Institute (https://www.barrowneuro.org/). Qualified applicants holding Ph.D., M.D. or equivalent degrees will be considered for appointment at assistant, associate or full professor levels. The successful candidate will be expected to direct an extramurally-funded research program in neurodegenerative disease research using interdisciplinary approaches. Institutional strategic interests for this position are in Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and traumatic brain injury. Qualified applicants in other areas of translational neuroscience also will be considered. The successful candidate is expected to synergize/collaborate with existing research and clinical faculty, will have access to core facilities and clinical samples, and may leverage opportunities to collaborate with investigators at affiliate institutes including Phoenix Children’s Hospital, the Translational Genomics Research Institute, and the University of Arizona. The successful candidate will receive a highly competitive start-up package and salary support.


Please send either an initial letter of inquiry in confidence or a full application including vita, names and addresses of three references, and brief statements of research experience, interests and career objectives either as hard copies or electronic copies to Neurodegenerative Disease Search, c/o Research Administration, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013 or via e-mail message and pdf or Word attachment to BNI_Research@dignityhealth.org.


Link: https://jobs.sciencecareers.org/job/468220/associate-professor/?LinkSource=PremiumListing
Employer: Barrow Neurological Institute
Location: Phoenix, AZ
Sector: Academia
Degree required: PhD or MD
Conditions: ALS
Job posted: October 26th, 2017
Barrow Neurological InstitutePhoenix, AZPhD or MDALSOct 26, 2017
Research Assistant, Spillantini Lab

Research Assistant, Spillantini Lab

(Click title to open job details in a new window.)
Description:

Applications are invited for a Research Assistant role to work on a collaborative project between the groups of Professor David Klenerman and Professor Maria Grazia Spillantini to study the molecular basis of neurodegenerative disease.


The work will primarily involve culturing, differentiating and maintaining human iPS cells and iPS-derived neurons but also working with neurons from wild type, transgenic and knockout mouse strains.

The aim of the project is to directly image protein aggregates in neurons to determine how and why aggregates accumulate with time leading to neuronal death.


The successful candidate will have a B.Sc. degree (or equivalent) in a relevant biological science and a strong background in human pluripotent stem cells differentiation and maintenances as well as experience in rodent neuronal cell culture.


Link: https://neuvoo.co.uk/view/?id=ge3g2yn5pp
Employer: University of Cambridge
Location: Cambridge, England
Sector: Academia
Degree required: BS
Conditions: NDG
Job posted: October 26th, 2017
University of CambridgeCambridge, EnglandBSNDGOct 26, 2017
Assistant Professor

Assistant Professor

(Click title to open job details in a new window.)
Description:

The Department of Biology at the University of Massachusetts, Amherst invites applications for a tenure-track position at the rank of Assistant Professor. The successful candidate will be a part of the Institute for Applied Life Sciences (IALS), which has a primary goal of developing translational research programs and fostering interactions with industry.


We seek highly innovative candidates who are exploring neurological/psychiatric diseases or disorders using clinically relevant animal models, spanning invertebrates to non-human primates. We are particularly interested in candidates whose research focus complements existing departmental and campus strengths, including neuroendocrinology, cytoskeletal dynamics, protein homeostasis, immunology and neurodevelopment. Possible areas of research could include neurodegenerative diseases, stroke, traumatic brain injury, autism or neuropsychiatric disorders. Successful recruits will be expected to establish and maintain a research program with direct relevance to issues of human health and that yield important mechanistic insight into diseases affecting the nervous system.


The new faculty member will collaborate with IALS faculty to translate research results into therapeutic candidates, interact with industry scientists, and provide essential training for the next generation of biomedical scientists. IALS and UMass Amherst are undertaking an aggressive program of faculty recruitment in the next two years. New faculty members will have access to the substantial IALS investments in campus infrastructure and core equipment facilities (see http://www.umass.edu/ials/core-facilities for more details).


Qualified candidates must have a Ph.D. in neuroscience or closely related field, postdoctoral experience, and outstanding potential to establish a translational neuroscience research program. Life sciences faculty members at UMass can recruit students from several interdepartmental graduate programs on campus, and the successful candidate will be expected to participate in teaching at the undergraduate and graduate levels.


Review of applications will begin on November 27, 2017 and will continue until the position is filled. Online applications must include a cover letter, CV, research plan, teaching statement, and the contact information for three references.


Link: http://neurojobs.sfn.org/jobs/10420677/assistant-professor
Employer: University of Massachusetts
Location: Amherst, MA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: October 25th, 2017
University of MassachusettsAmherst, MAPhDNDGOct 25, 2017
Director, Center for Neurodegenerative Disorders (Physician-Scientist)

Director, Center for Neurodegenerative Disorders (Physician-Scientist)

(Click title to open job details in a new window.)
Description:

The University of Maryland Department of Neurology is seeking a senior level physician scientist with expertise in dementia and neurodegeneration to serve as the Director of the Center for Neurodegenerative Disorders. Specifically, the Department is seeking an investigator with a strong history of external funding whose work focuses on the molecular and cellular pathogenesis of neurodegenerative disorders including Alzheimer’s disease (AD), Huntington’s disease (HD), Fronto-temporal dementia (FTD), or hereditary ataxias (HA).


S/he should have expertise in molecular genetics including whole genome or whole exome screening, SNP or CGA array analysis as a means to identify novel genes that are causative for neurodegenerative disorders in human patients or to screen modifier loci associated with phenotypic variability.


The selected candidate should be clinically trained in cognitive neurology or a related discipline and should be willing to see patients with neurodegenerative disorders such as dementia in the outpatient neurology setting.


For complete details or to apply, contact Lexi Cejka at Lexi.Cejka@grantcooper.com.


Link: https://main.hercjobs.org/jobs/10411320/director-of-center-for-neurodegenerative-disorders-neurology
Employer: University of Maryland
Location: Baltimore, MD
Sector: Academia
Degree required: MD
Conditions: FTD
Job posted: October 25th, 2017
University of MarylandBaltimore, MDMDFTDOct 25, 2017
Postdoctoral Fellow, Sareen Lab

Postdoctoral Fellow, Sareen Lab

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Description:

Dr. Dhruv Sareen’s independent research laboratory at the Cedars-Sinai Medical Center, Regenerative Medicine Institute focuses on using human iPSC technology to understand the molecular mechanisms underlying neurodevelopmental/degenerative diseases and how obesity is linked to the brain. His laboratory is particularly interested ‘disease-in-a-dish’ modeling for neuromuscular, neurodegenrative and motor neuron diseases including, amyotrophic lateral sclerosis (ALS). They are particularly interested in C9orF72 and other genetic forms of ALS and what are the common elements with sporadic forms of ALS. Using the iPSC platform his lab has developed novel methods for drug screening on patient motoneurons and dissecting mechanisms for motoneuron degeneration. In the context of stem cell modeling of neurodevelopmental (SMA) and neurodegenerative diseases (ALS) Dr. Sareen’s group is particularly interested in the mechanistic insights how specific neural cell types degenerate during the disease processes. They are using OMICS (proteome, transciptome, metabolome) and imaging methodologies to gain mechanistic insights into the mitochondrial and endorplasmic reticulum stress involvement. In addition, by understanding how the cells of the nervous system develop and differentiate we will be able to develop better and safer cells for transplantation and regenerative therapies. Dr. Sareen’s group has extensive experience in pluripotent and neural stem cell research. He has developed and directed a well-renowned human iPS cell core. He has published high-profile manuscripts on human iPSC-based disease modeling in SMA and ALS.


Dr. Sareen’s laboratory is searching for a highly-capable Post-doctoral Researcher to join his research group to investigate disease mechanisms in neurodegenerative diseases, especially motor neuron disorders. The incumbent should have experience in in neurobiology, biochemistry, molecular biology and stem cells, including analyzing their genetic and biochemical profiles by OMICS technologies. Bioinformatics (programming in R) knowledge is a plus. By using human iPS cell technology and differentiating into different brain cells as well as other tissues of the body we will investigate brain-linked disease mechanisms to develop assays in patient-derived enural cell types and screen for novel therapeutics. Working independently but in close cooperation and in consultation with the PI and other Research Scientists at RMI, the Post-doctoral Researcher will perform routine and complex laboratory procedures throughout. The Post-doctoral Researcher will be expected to assist the PI in preparation of multiple grant proposals and submission of such proposals. They will also prepare full manuscripts for publication as primary first and co-authors. The researcher will be expected to assist the PI in maintaining institutional IRB/SCRO protocols as well as develop new animal and IACUC protocols. The incumbent will develop, adapt, and implement new research techniques and protocols and will analyze and interpret data. They will participate in presentations as author or co-author on scientific meeting abstracts.


Under the direction of Dr. Sareen (PI) the incumbent will help us achieve our research goals by performing the principal duty of using pluripotent and neural stem cell culture techniques to generate neuronal and other tissue differentiation protocols, characterization of the differentiated cells (control vs disease) using techniques such as gene and protein expression, physiological, and phenotypic assessments. The candidate will also be expected to develop and perform differentiation protocols to direct pluripotent stem cells to endoderm, ectoderm and mesoderm lineages. The successful candidate will be responsible for all cell maintenance, expansion and genetic modification using viral vectors or other gene-editing methods. Therefore, experience in stem cell and neurobiology, knowledge of pluripotent/neural cell markers combined with a proven record in stem cell culture techniques is essential. Experience with bioinformatics analysis of RNA-seq and mass spec proteomics data are important.


Prior experience in novel genome-editing technologies (CRISPR/Cas9) using pluripotent stem cells is a great asset. Prior experience in high-content compound screening/imaging techniques, handling of the Molecular Devices Image Express Micro system, and a Mass Spectrometer with data analysis are preferred traits. Proficiency in computer algorithm development for automating image-based analysis is also a desirable trait.


Link: https://www.cedars-sinaimedicalcenter.apply2jobs.com/ProfExt/index.cfm?fuseaction=mExternal.showJob&RID=26507&CurrentPage=29
Employer: Cedars Sinai
Location: Los Angeles, CA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: October 25th, 2017
Cedars SinaiLos Angeles, CAPhDALSOct 25, 2017
Research Technician, Morrison and Rothstein Labs

Research Technician, Morrison and Rothstein Labs

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Description:

A Research Technologist to work in the laboratories of Drs. Brett Morrison and Jeffrey Rothstein in the Department of Neurology. Our laboratories study the pathogenesis of the devastating motor neuron disease, amyotrophic lateral sclerosis (ALS; commonly referred to as Lou Gehrig’s disease). A particular focus is on the role played by oligodendrocytes, a key support cell in the brain that is dysfunctional and degenerates in ALS.


Specific duties & responsibilities:


The responsibilities include but are not limited to perform laboratory task following routine and established protocols. Perform lab experiments following protocols. Work collaboratively with the other members of the lab (principal investigators, post-docs, graduate students, and research technicians) on ongoing projects. . In addition to performing laboratory experiments, ongoing responsibilities will include the management of a transgenic mouse colony, assisting the laboratory manager with the ordering of laboratory supplies, and attending all required laboratory meetings. Will have opportunity to pursue new projects independently.


Link: https://jobs.jhu.edu/job/Baltimore-Research-Technologist-MD-21205/437413200/
Employer: Johs Hopkins University
Location: Baltimore, MD
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: October 20th, 2017
Johs Hopkins UniversityBaltimore, MDBA or BSALSOct 20, 2017
Research Assistant

Research Assistant

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Description:

Applications are invited for a Research Assistant to join the Dementia Research Centre (DRC), an established and internationally regarded multi-disciplinary research group. The post-holder will be part of a research programme dedicated to the detailed characterization of frontotemporal dementia (FTD) and its associated disorders, motor neurone disease, corticobasal syndrome and progressive supranuclear palsy. The programme aims to provide the evidence base for future clinical trials in this important condition.


The post-holder will participate in the image analysis activities of the FTD studies at the DRC and the wider international collaborative FTD studies that the DRC are involved in, particularly the Genetic FTD Initiative (GENFI) study. Tasks will include upload, curation, quality control, segmentation and analysis of brain imaging (mainly magnetic resonance imaging, MRI).


The post is available from September 2017 and is funded by the MRC for one year in the first instance. Starting salary on the UCL grade Grade 6b in the range £30,316 – £31,967 pa (including London Allowance)


You should apply for this post through UCL’s online recruitment – www.ucl.ac.uk/hr/jobs where you can download a job description and person specification using ref: 1684053


If you have any queries regarding the application process, please contact Samantha Robinson, HR Officer, Institute of Neurology, 23 Queen Square, London, WC1N 3BG (email: ion.hradmin@ucl.ac.uk).


Link: http://www.jobs.ac.uk/job/BFA371/research-assistant/
Employer: University College London
Location: London, England
Sector: Academia
Degree required: BS (A minimum of upper second-class honors degree.)
Conditions: ALS, FTD
Job posted: October 18th, 2017
Applications close: November 7th, 2017
University College LondonLondon, EnglandBS (A minimum of upper second-class honors degree.)ALS, FTDOct 18, 2017
Assistant Professor, Neuroscience

Assistant Professor, Neuroscience

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Description:

The Department of Neuroscience at Yale University seeks to hire faculty who work in the following area: Molecular, cellular and genetic approaches to study the development and function of the nervous system and its dysfunction in disease.


Emphasis will be placed on recruiting at the level of Assistant Professor, but excellent applicants at Associate Professor level will also be considered. We seek candidates with an exceptional track record, potential for outstanding future achievements, and a wish to participate in a dynamic and recently expanded neuroscience community at Yale that includes the Kavli Institute for Neuroscience, the Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR) and the Swartz Center. We are especially interested in candidates who will contribute to the diversity of our academic community. Candidates are expected to develop a productive and innovative research program and will have the opportunity to participate in graduate and medical education.


Candidates must hold a Ph.D., M.D., or equivalent degree. Please send a cover letter, curriculum vitae, up to 3 representative publications, a research plan (strictly limited to 2 pages), and arrange for submission of 3 letters of recommendation. All application materials should be submitted electronically to apply.interfolio.com/45825. Applications will be reviewed as they are received and until the position is filled with priority given to those applications received by November 17, 2017.


Link: https://apply.interfolio.com/45825
Employer: Yale University
Location: New Haven, CT
Sector: Academia
Degree required: PhD or MD
Conditions: NDG
Job posted: October 16th, 2017
Applications close: December 16th, 2017
Yale UniversityNew Haven, CTPhD or MDNDGOct 16, 2017
Assistant, Associate or Full Professor

Assistant, Associate or Full Professor

(Click title to open job details in a new window.)
Description:

The newly formed Iowa Neuroscience Institute at the University of Iowa is recruiting a tenure-track faculty member who seeks a vibrant intellectual, interdisciplinary, and collaborative environment to solve fundamental problems in brain disorders. Together, we are working to develop better treatments for people and their families who live with neurodevelopment, neurological, and psychiatric disorders.


The Iowa Neuroscience Institute, in conjunction with the Departments of Anatomy & Cell Biology, Biochemistry, Biomedical Engineering, Biology, Molecular Physiology & Biophysics, Pharmacology, Psychiatry, Psychological & Brain Sciences and the Colleges of Medicine, Liberal Arts & Sciences, and Engineering, is seeking tenure-track faculty with expertise in any of the above disciplines with a focus on neuroscience.

The institute is particularly interested in researchers working in the areas of: neural circuits and behavior; neurogenetics and epigenetics; and modeling of neurological and psychiatric disorders in animal and cellular systems, with a particular focus on identifying and developing new therapeutic opportunities for patients. Salary ($100,000.00 to commensurate) is based on academic level of entry and on the applicant’s qualifications and responsibilities.


Qualifications include PhD and/or MD degree, and applicable training to support the appointment, including clinical training where appropriate. Positions are available at Assistant through full Professor ranks, in the tenure track. Applicants should have demonstrated ability in research and teaching, including high-profile publications, with clear potential for supporting an innovative and productive research program.

Candidates must have previous records consistent with appointment as a tenured professor. This includes a PhD or MD degree or equivalent and an outstanding record of accomplishments in research, teaching, and service.


Applicants must have a relevant doctoral degree and productive research experience focusing on topics of broad interest in neuroscience. These may include, but not be restricted to areas such as neural circuits and behavior; neurogenetics and epigenetics; and modeling of neurological and psychiatric disorders in animal and cellular systems.


To apply:


Complete the job application (requisition # 71584) at jobs.uiowa.edu and include a CV, letter of interest, and a 3 to 5 page summary of research accomplishments and future plans.

All applicants will be asked to provide names of three referees. Letters of recommendation are required as part of the application process. Upon submission, references selected will be notified by e-mail with directions on how to electronically submit letters to the University of Iowa.

Consideration of completed applications will begin immediately.


For more information, contact:

Ted Abel – Iowa-Neuroscience-Institute@uiowa.edu

Cmed-Physiology

PAPPAJOHN BIOMEDICAL DISCOVERY BLDG

169 NEWTON ROAD

2312 PBDB

IOWA CITY, IA 52242

Department URL: https://medicine.uiowa.edu/iowaneuroscience/


Link: https://jobs.uiowa.edu/faculty/view/71584
Employer: Iowa Neuroscience Institute
Location: Iowa City
Sector: Academia
Degree required: PhD and/or MD
Conditions: NDG
Job posted: October 16th, 2017
Applications close: December 9th, 2017
Iowa Neuroscience InstituteIowa CityPhD and/or MDNDGOct 16, 2017
Postdoctoral Fellow, Bonanomi Lab

Postdoctoral Fellow, Bonanomi Lab

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Description:

Two postdoctoral positions are available in the laboratory of Molecular Neurobiology at San Raffaele Institute in Milan to study development and degeneration of spinal motor neurons using mouse genetics, cellular approaches, and advanced genomic/proteomic techniques. The San Raffaele Institute is an international biomedical center with well-integrated basic and translational programs, offering a vibrant research environment and state-of-the-art platforms.


Our laboratory is supported by the ERC and the Armenise-Harvard Foundation to investigate the molecular and cellular underpinnings of neuronal connectivity and how these processes are deregulated in disorders of the spinal motor system that controls movements. Current projects focus on (i) mechanisms of axon pathfinding and neuronal morphogenesis; (ii) neurovascular interactions in the developing nervous system and nerve regeneration; (iii) the molecular basis of motor neuron diseases, including Amyotrophic Lateral Sclerosis (ALS). Please visit the lab website for further information: http://www.hsr.it/research/organization/divisions-centers/division-of-neuroscience/molecular-neurobiology/


We are seeking highly motivated, interactive and creative individuals with a PhD and proven track record of research and publications in a relevant area of biological sciences – molecular neuroscience, developmental and cell biology, neurovascular signaling, neurodegenerative diseases. Candidates with a strong background in endothelial biology who want to explore the crosstalk between neuronal and vascular systems in development and neurological disorders are also welcome to apply. Experience in bioinformatics is a plus.


The appointments are available immediately and applications will be considered until the positions are filled. This is an excellent opportunity for talented and driven individuals who want to perform cutting edge research at the intersection of basic and translational molecular neuroscience and neurovascular biology.


Applicants should submit a CV and cover letter with a summary of previous work and future research interests, along with contacts of 2 references to: Dario Bonanomi (bonanomi.dario@hsr.it)


Link: https://www.nature.com/naturejobs/science/jobs/627021-postdoctoral-positions-in-molecular-neurobiology
Employer: San Raffaele Institute
Location: Milan, Italy
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: October 16th, 2017
Applications close: December 15th, 2017
San Raffaele InstituteMilan, ItalyPhDALSOct 16, 2017
Research Scientist, Gao Lab

Research Scientist, Gao Lab

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Description:

A position at the junior postdoctoral or Research Scientist level is immediately available in the laboratory of Dr. Fen-Biao Gao at the University of Massachusetts Medical School to study molecular pathogenic mechanisms of fronototemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) (Lu et al., Mol. Cell 2013; Gascon et al., Nat. Med. 2014; Freibaum*, Lu* et al., Nature 2015; Tran et al., Neuron 2015; Lopez-Gonzalez et al., Neuron 2016). Candidates with strong research experience in mouse genetics and molecular and cellular biology are encouraged to apply. Interested please send CV to fen-biao.gao@umassmed.edu


Link: https://www.nature.com/naturejobs/science/jobs/627025-junior-postdoctoral-or-research-scientist-umass-medical-school
Employer: University of Massachusetts Medical School
Location: Worcester, MA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: October 16th, 2017
Applications close: December 15th, 2017
University of Massachusetts Medical SchoolWorcester, MAPhDALSOct 16, 2017
Postdoctoral Fellow, Strittmatter Lab

Postdoctoral Fellow, Strittmatter Lab

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Description:

Postdoctoral positions are available to study neural repair and/or neurodegeneration in Stephen Strittmatter’s laboratory.


Neural repair mechanistic studies are based on whole-genome loss-of-function discovery of novel pathways essential to limit axon regeneration. Work involves in vivo gene editing, functional outcomes and translation to therapeutic development. Models include traumatic spinal cord injury, head injury, optic nerve crush and glaucoma.


Neurodegeneration research based on unbiased discovery of neuronal pathways mediating the toxicity of misfolded disease-related proteins. Investigations include functional and biochemical assays in neuronal cultures, activity and behavioral studies in gene-targeted mouse models, structural analysis by NMR and cryo-EM, and development of novel therapeutics for neurodegenerative diseases. Focus on Alzheimer’s, disease, Fronto-temporal dementia and Parkinson’s disease.


Funded by NIH grants R35NS097283, R01AG034924, RF1AG053000, U01EY027256, P50AG047270 and UH3TR000967.


Highly motivated to neuroscience discovery.


Peer-reviewed first-author original research publications.


Ph.D. in Neuroscience or related field.


Link: http://neurojobs.sfn.org/jobs/10370264/neural-repair-and-or-neurodegeneration-postdoctoral-fellowship
Employer: Yale School of Medicine
Location: New Haven, CT
Sector: Academia
Degree required: PhD
Conditions: FTD
Job posted: October 12th, 2017
Yale School of MedicineNew Haven, CTPhDFTDOct 12, 2017
Senior Research Investigator

Senior Research Investigator

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Description:

We are currently looking for Senior Research Investigator (SRI), Translational Research, to work in one of the several therapeutic areas we work with such as motor neuron, neurodegenerative, and lysosomal storage diseases.


As an SRI, Translational Research, you will be involved in translational research projects in one or more therapeutic areas. In each case, you will be working in the setting of large interdisciplinary teams, where you will function independently in the execution of the experiments but will need to work collaboratively with other team members. Working independently, you will perform design, optimization, and implementation of complex in vitro and in vivo experiments in rodents and NHP within specified timelines; provide cross-organizational support for the essential laboratory functions, including effective management of laboratory resources, and participation in maintenance of centralized reagents; contribute to writing/reviewing manuscripts, preparing presentations, establishing collaborations as well as writing/reviewing protocols and SOPs.


Link: https://www.linkedin.com/jobs/view/308194466/
Employer: University of Pennsylvania School of Medicine
Location: Philadelphia, PA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: October 12th, 2017
University of Pennsylvania School of MedicinePhiladelphia, PAPhDNDGOct 12, 2017
Research Technician

Research Technician

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Description:

The VIB-KU Leuven Center for Brain & Disease Research is part of the VIB Life Sciences Institute and is embedded within the University of Leuven, which ranks among the world’s top 50 universities. At our center, researchers want to force a breakthrough in the cure of neuronal and neurodegenerative disorders. This requires a deep understanding of normal brain function and translation of this knowledge into a solid mechanistic understanding of disease mechanisms.


Our center is committed to translate basic research findings into value for society. We are looking for a highly motivated and flexible research technician to support translational research projects in our center. This entails the development of disease targets, setting up screening assays and coordinating interactions with the drug discovery unit of the institute.


Link: https://www.nature.com/naturejobs/science/jobs/619293-research-technician-translational-research-projects
Employer: VIB
Location: Ghent, Belgium
Sector: Academia
Degree required: BA or BS
Conditions: NDG
Job posted: October 11th, 2017
Applications close: December 11th, 2017
VIBGhent, BelgiumBA or BSNDGOct 11, 2017
Postdoctoral Fellow, Pathology

Postdoctoral Fellow, Pathology

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Description:

This position is funded by ForeFront, an NHMRC Program grant, that brings together a multidisciplinary research team to address the diagnosis, management and treatment of frontotemporal dementia and related disorders. A junior postdoctoral researcher is required to contribute to projects exploring the pathogenesis of neurodegeneration with a particular focus on immune-mediated mechanisms. This is a valuable opportunity to expand your research skills.


Full-time fixed term up until 31st December 2018 with possibility of renewal up to five years. Remuneration package: $106K – 114K p.a. which includes base salary $90K – $96K, leave loading and up to 17% superannuation


Main Responsibilities Will Be To

*assist with the development of new projects investigating inflammatory aspects of neurodegeneration

*undertake data collection and analysis.


About You

The University values courage and creativity; openness and engagement; inclusion and diversity; and respect and integrity. As such, we see the importance of recruiting talent aligned to these values and are looking for a Postdoctoral Research Associate to support the Neuropathology team who will:

*contribute to the development of research projects in the area of neurodegenerative disorders

*assist other researchers and students with various tasks including data collection and analysis

*prepare and contribute to publications, presentations and reports

*contribute to grant applications

*co-ordinate various administrative tasks associated with research projects.


To Succeed In This Role You Will Have

*a PhD in any field relevant to pathology, or related discipline

*previous research experience including skills in immunology or related field

*demonstrated contributions to peer reviewed publications

*clear career goals to develop a nationally competitive research profile.


The successful applicant will be able to collaborate with other groups within the ForeFront team and contribute to research outcomes of the program. Strong communication and interpersonal skills are essential as is a sound basis in responsible research conduct. The opportunity also exists to contribute to the supervision of research students and develop skills in neuropathology.


Intending applicants are welcome to seek further information about the position from Professor Jillian Kril on 02 9036 7118.


For recruitment-related enquiries, or if you require reasonable adjustment or support filling out this application, please contact Melanie Leshetz on 02 8627 1220 or melanie.leshetz@sydney.edu.au


Link: https://www.linkedin.com/jobs/view/473811164/
Employer: University of Sydney
Location: Sydney, Australia
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: October 10th, 2017
University of SydneySydney, AustraliaPhDALS, FTDOct 10, 2017
Research Associate, Neuroimaging

Research Associate, Neuroimaging

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Description:

One Research Associate position is currently available at the Laboratory of Neuro Imaging in the area of neuroimaging genetics, involving the development of algorithms for the identification of novel multimodal (imaging and genetic) feature combinations and models that explain such imaging-genetic interactions and facilitate diagnoses and prognoses in neuropsychiatric, neurodegenerative, and neurodevelopmental brain disorders. Additional responsibilities will be to train student researchers and interact with other laboratory assistants on common projects. Other key responsibilities will be documentation of procedures using word processing, data base and web-based applications, and supervised statistical analyses, figure and table preparation for various manuscripts and scientific presentations. The successful candidate will have a strong background in multimodal brain image analysis, large-scale genetic association study and statistical modeling. Knowledge of neuroanatomy and basic neuroscience, computer programming experience (working knowledge of Linux, Matlab, R, Python, C/C++, etc.) and excellent communication and writing skills are desired. Experience on database, bioinformatics, graphical models, dimensionality reduction, and machine learning is desirable.


Minimum Education: Ph.D. or equivalent doctorate

Minimum Experience: 1 year

Minimum Field of Expertise: Directly related education and experience in research specialization with advanced knowledge of equipment, procedures and analysis methods.


Link: https://usccareers.usc.edu/job/-/-/1209/5930770
Employer: University of Southern California
Location: Los Angeles, CA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: October 9th, 2017
University of Southern CaliforniaLos Angeles, CAPhDNDGOct 09, 2017
Assistant Professor, Medicinal Chemistry

Assistant Professor, Medicinal Chemistry

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Description:

The University of Illinois at Chicago, College of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy seeks candidates for a full-time, tenure-track faculty position at the rank of Assistant Professor. Successful candidates will have the potential to develop and maintain a strong, extramurally funded, independent research program.


Duties:

The new faculty is expected to establish strong collaborations with the department faculty and play an active role in the UICentre for Drug Discovery. Teaching in the professional and graduate programs of the College of Pharmacy is required.


Qualifications:

A PhD degree in Synthetic Organic or Medicinal Chemistry or related discipline and relevant postdoctoral experience are required. Priority will be given to research in synthetic medicinal chemistry, preferably in the area of cancer, neurodegenerative diseases and/or the human microbiome.


Job ID #86425


Link: https://jobs.uic.edu/job-board/job-details?jobID=86425
Employer: University of Illinois
Location: Chicago, IL
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: October 8th, 2017
Applications close: November 13th, 2017
University of IllinoisChicago, ILPhDNDGOct 08, 2017
Assistant, Associate, Full Professor, Pathology and Cell Biology

Assistant, Associate, Full Professor, Pathology and Cell Biology

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Description:

The Department of Pathology and Cell Biology at the Columbia University Medical Center seeks highly qualified individuals for faculty positions in surgical pathology, clinical pathology and research. Appointments can be at the Instructor, Assistant, Associate, Professor, or Associate Research Scientist level depending on experience and qualifications. All positions require outstanding academic credentials and a record of scholarly productivity. Clinical positions require board certification and a license in NYS. Columbia University’s Department of Pathology & Cell Biology invites applications for a junior/senior level faculty position. Candidates should have a strong record of research and teaching qualifications (distinction). Candidates will be expected to sustain an active research and publication portfolio and supervise graduate students, and fellows. Candidate will play a vital role in Departmental activities.


Minimum Qualifications: Depending on the field of research and current needs for field and instructional coverage within the department, certain subspecialties may be preferred. Current research specialties: Cancer Biology, Neurodegenerative diseases, Cellular and molecular neurobiology, Cell motility, cytoskeleton and intracellular trafficking, Virology, Neuronal stem cells.


Preferred Qualifications: Depending on the field of research and current needs for field and instructional coverage within the department, certain subspecialties may be preferred.


Link: https://main.hercjobs.org/jobs/10351210/instructor
Employer: Columbia University
Location: New York, NY
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: October 6th, 2017
Columbia UniversityNew York, NYPhDNDGOct 06, 2017
Cognitive Clinical Research Nurse

Cognitive Clinical Research Nurse

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Description:

The Cognitive Clinical Research Nurse is responsible to promote organizational values of patient and visitor satisfaction by demonstrating courtesy and respect for families, visitors and other employees. Cares for patients in all age groups from young adult through geriatrics. Demonstrates competence in the assessment, treatment and care of patients serviced. Works in collaborative practice setting with supervising/collaborating physicians to care for patients within the Penn Frontotemporal Degeneration Center.


Responsible for the plan of care and utilizing the nursing process in the delivery of care in conjunction with treating physicians and nurse. The nurse will facilitate the coordination of care, and demonstrate safe practice within the domains of clinical judgment and decision making, nurse-patient/family relationship, clinical leadership and clinical scholarship.


Responsible as well for coordination of nursing component of clinical research activities within the Penn Frontotemporal Degeneration Center. Provides specialized education and oversight concerning research studies and facilitates the conduct of those clinical research assigned within the Center. Duties include informed Consent, the precise collection and data entry of study, and department related information and activities into appropriate data bases. Interaction with primary investigators and study team members during IRB submissions. Helps completes Investigational Drug and Device FDA paperwork related to assigned research projects. Participates in direct patient care within the scope of clinical research protocols. Assists in new protocol development, Grant submissions and Quality Control.


Link: https://careers.peopleclick.com/careerscp/client_pennmedicine/external/gateway/viewFromLink.html?jobPostId=67899&localeCode=en-us&source=LinkedIn&sourceType=PREMIUM_POST_SITE
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: RN
Conditions: FTD
Job posted: October 6th, 2017
University of PennsylvaniaPhiladelphia, PARNFTDOct 06, 2017
Postdoctoral Fellow, Boulis Lab

Postdoctoral Fellow, Boulis Lab

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Description:

The Boulis laboratory in the department of Neurosurgery at Emory University in Atlanta, GA, is seeking a capable and self-motivated individual to oversee projects involving the transplantation of iPS cells for the treatment of motor neuron diseases and nerve damage.


The candidate should hold a Ph.D. in an appropriate field and have a strong publication record in neuroscience and related fields. The ideal candidate will have experience with creating iPS cells from human and rodent cells and differentiating them into motor neurons. The candidate should also have excellent oral and written communication skills and the ability to work as part of a team. Experience working with rodent models is preferred. Salary and title will be commensurate with experience


To apply for this position, please go to Emory’s Career page and job requisition #76107BR – Assistant Academic Research Scientist.


https://sjobs.brassring.com/TGnewUI/Search/Home/Home?partnerid=25066&siteid=5043#home


Link: https://sjobs.brassring.com/TGnewUI/Search/Home/Home?partnerid=25066&siteid=5043#home
Employer: Emory University
Location: Atlanta, GA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: October 4th, 2017
Emory UniversityAtlanta, GAPhDALSOct 04, 2017
Research Scientist, Pathology

Research Scientist, Pathology

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Description:

The Department of Pathology currently has an outstanding opportunity for a Research Scientist/Engineer 2. Under the general direction of the PI, this position provides comprehensive research to develop biomarkers for the diagnosis and staging of neurodegenerative diseases, and for the evaluation of potential disease modifying agents.


Research focuses for this position include but are not limited to:


*Support protein expression, purification, and post-translational modification efforts

*Investigate underlying pathological mechanisms

*Identify and evaluate the roles of key biomarkers in the disease process

*Demonstrate a mastery of major immunologically based technologies; Qiagen’s Luminex, Meso *Scale Discovery’s, electro chemiluminescent detection and Simoa’s Quanterix platforms.

*Develop and validate immune-assays for candidate biomarkers

*Conduct immune-assays using major immunologically based technologies

*Contribute to the design and execution of cell and tissue based studies to investigate biological mechanisms of neurodegeneration

*Collect and acquire human clinical biological samples


Responsibilities:


Masters in any related Life science, Biomedical Engineering or Chemistry And two to four years’ experience or an equivalent education and experience.


Working knowledge of ELISA and/or other immunologically based assay; Protein expression, purification and post-translational modifications. Cell and/or tissue based studies.


Link: https://main.hercjobs.org/jobs/10345439/research-scientist-engineer-2
Employer: University of Washington
Location: Seattle, WA
Sector: Academia
Degree required: MS
Conditions: NDG
Job posted: October 4th, 2017
University of WashingtonSeattle, WAMSNDGOct 04, 2017
Research Fellow, McCormick Lab

Research Fellow, McCormick Lab

(Click title to open job details in a new window.)
Description:

We are seeking a Research Fellow in the Department of Biomedical Sciences to commence as soon as possible.The main focus of this research is to determine whether the human endogenous retrovirus HERV-K contributes to sporadic Amyotrophic Lateral Sclerosis (sALS)/ Motor Neurone Disease, as suggested in a ground-breaking study by Li et al (Sci Transl Med. 2015 Sep 30; 7 (307):307ra153). The successful candidate will develop and standardise HERV-K and HERV-W specific qPCR assays that are MIQE compliant, to measure expression levels of HERV transcripts in human post-mortem brain and blood from patients and controls. Next generation sequencing (NGS) will also be performed to look for HERV-K sequence variants associated with sALS and digital PCR will be employed to measure HERV-K DNA copy number. Optionally, microarray analysis may be undertaken to provide a broader screening of HERV expression patterns. The research proposed will allow us to gain a better understanding of sALS pathogenesis and may provide novel diagnostic markers and targets for treatment development and monitoring in this fatal neurological disease.


The post is based within Dr Adele McCormick’s group in the Faculty of Science and Technology (University of Westminster). The research will be undertaken in close collaboration with Professor Ammar Al-Chalabi (Maurice Wohl Clinical Neuroscience Institute, King’s College London), Dr Jeremy Garson (Division of Infection and Immunity, University College London) and Dr Jim Huggett (LGC Group, Teddington).


Candidates must hold a PhD in virology/molecular biology or the equivalent in professional qualifications and experience. Candidates must also have a proven record of successful research with experience of real-time qPCR and NGS. Knowledge of bioinformatic software packages would also be desirable.


Administrative contact (for queries only): Recruitment@westminster.ac.uk


Job reference number: 50046026


Closing date: 27 October 2017


Interviews are likely to be held on: W/C 30 October 2017


Link: https://vacancies.westminster.ac.uk/Hrvacancies/default.aspx?id=50046026
Employer: University of Westminster
Location: London, England
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: October 3rd, 2017
Applications close: October 27th, 2017
University of WestminsterLondon, EnglandPhDALSOct 03, 2017
Assistant and Associate or Full Professor, Neurodegeneration and Neurotherapeutics

Assistant and Associate or Full Professor, Neurodegeneration and Neurotherapeutics

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Description:

Duke University invites applications for potential tenure-track faculty members to join our newly established Duke Center for Neurodegeneration and Neurotherapeutics, which will be directed by Dr. Al La Spada. In the academic year 2017-18, we are searching for talented investigators to fill two faculty positions. Appointments may be at any level, with an expectation that one position will be filled by an early-stage investigator who would start his/her independent career at Duke, and one position will be filled by a mid-career investigator at the Associate Professor rank or a senior investigator at the Professor rank.


Ideal applicants will be employing genetic, molecular, cellular, and/or neurobiological approaches to the study of neurodegenerative diseases, including especially Alzheimer’s disease, Parkinson’s disease, ALS, or frontotemporal dementia. Successful candidates will have track records of creativity and productivity, demonstrated potential for outstanding future achievement, and a desire to participate in an exciting, interactive, and growing neuroscience and neurological disease research community. All Center faculty will be expected to mount a productive and innovative research program, obtain extramural funding, and actively participate in graduate student, medical student, and postdoctoral fellow education. Candidates must hold a Ph.D., M.D., M.D.-Ph.D., or equivalent degree(s). Qualified women and minority candidates are especially encouraged to apply.


For full consideration, applications should be submitted by November 30th, 2017, although applications will be considered until the initial two positions are filled. Applicants should submit a curriculum vitae, a brief summary of current and proposed research, reprints of 3 key publications, and 3 letters of recommendations.


Submit the following items online at this website to complete your application:

Cover Letter

Curriculum Vitae

Research Statement

Three Reference Letters


Questions may be directed to Al La Spada, Director of the Duke Center for Neurodegeneration and Neurotherapeutics: al.laspada@duke.edu


Link: https://academicjobsonline.org/ajo/jobs/9990
Employer: Duke University Medical Center
Location: Durham, NC
Sector: Academia
Degree required: PhD, MD or MD/PhD
Conditions: ALS, FTD
Job posted: September 29th, 2017
Applications close: November 30th, 2017
Duke University Medical CenterDurham, NCPhD, MD or MD/PhDALS, FTDSep 29, 2017
Postdoctoral Fellow

Postdoctoral Fellow

(Click title to open job details in a new window.)
Description:

The international “Regulatory T cell responses at the crossroads of immune homeostasis and inflammation in the context of barrier diseases” (TregBar) project is an international research project funded by the Luxembourg National Research Fund`s (FNR) bilateral AFR funding instrument. The program will initiate long-term collaborations between the biomedical initiatives of the Luxembourg Institute of Health (Esch-sur-Alzette, Luxembourg) and the Luxembourg Centre for Systems Biomedicine of the University of Luxembourg with the RIKEN Center for Integrative Medical Sciences (IMS) in Yokohama, Japan.


To address the open questions on the balance of the immune system, the project will investigate functional gene regulatory and signaling networks of regulatory Tregs in the context of several barrier diseases by using various murine and human disease models. For this purpose, the collaborative project will combine expertises in basic immunology especially on Tregs, microbiome, single cell analysis, clinical immunology, deep immune phenotyping and computational network analysis.


The successful candidate will therefore work in strong collaboration with different groups and perform single cell transcriptomics analysis using our established DropSeq pipeline and Fluidigm platform to investigate underlying molecular mechanisms of the immune system. The candidate will also spend up to 6 month at the RIKEN institute in Yokohama for additional training on disease models.


Link: https://jobs.sciencecareers.org/job/464797/postdoctoral-researcher-position-research-associate-in-systems-biomedicine-m-f-/
Employer: University of Luxembourg
Location: Esch-sur-Alzette, Luxembourg
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: September 29th, 2017
University of LuxembourgEsch-sur-Alzette, LuxembourgPhDNDGSep 29, 2017
Research Technician, Maniatis Lab

Research Technician, Maniatis Lab

(Click title to open job details in a new window.)
Description:

The Maniatis lab iat CUMC is seeking a highly motivated Technician B to work on a project focusing on the role of innate immunity and autophagy pathways on the progression of the neurodegenerative disease Amyotrophic Lateral Sclerosis (ALS). The technician will work closely with colleagues using techniques such as gene expression profiling, in vitro cell culture assays, and in vivo mouse genetics.


Principal Responsibilities:

Cell culture and Western blotting to study protein-protein interactions; Real-time PCR analysis of gene expression; General molecular cloning techniques for the production of recombinant plasmids and proteins; Genotyping and general maintenance of mouse colony; Sectioning and antibody staining of tissues for gene expression analysis; CRISPR experiments to generate genetically modified human and mouse cells.


Link: https://main.hercjobs.org/jobs/10325769/technician-b
Employer: Columbia University
Location: New York, NY
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: September 29th, 2017
Columbia UniversityNew York, NYBA or BSALSSep 29, 2017
Research Assistant, MND

Research Assistant, MND

(Click title to open job details in a new window.)
Description:

We are seeking a Research Assistant in Motor Neuron Disease to join the Nuffield Department of Clinical Neurosciences (NDCN). The post offers the opportunity to become proficient in the culture of fibroblasts, and motor and cortical neurons from iPSCs and to gain experience in neurodegeneration research as it relates to motor neuron disease (amyotrophic lateral sclerosis). As such the post would be very suitable for a bioscience graduate who is considering going on to study for a doctorate in neuroscience.


Your key responsibilities include, but are not limited to: the provision of research support for the Motor Neuron Disease research group, contributing to: the maintenance and analysis of neuronal cultures derived from induced pluripotent stem cells (iPSCs) from patients seen in the Oxford Motor Neuron Disease clinic; the processing and biobanking of biosamples (blood, urine, cerebrospinal fluid and skin biopsies) from patients participating in a major biomarker research project entitled ‘A Multicentre Biomarker Resource Strategy in ALS’ (AMBRoSIA).


You will have experience of following and adapting laboratory protocols and selecting appropriate experimental methodologies, pursue a degree in a relevant discipline (e.g. biological sciences, including neuroscience), possess sufficient specialist knowledge in the discipline to work within the established research programmes, along with excellent communication skills, including the ability to write text that can be published, present data at conferences, and represent the research group at meetings.


The post is full-time for a fixed-term of 1 year (12 months) in the first instance.


Only applications received before 12.00 midday on Thursday 19 October 2017 will be considered.


Link: https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.display_form?p_internal_external=E&p_applicant_no=&p_form_profile_detail=&p_recruitment_id=131289&p_display_apply_ind=Y&p_company=10&p_process_type=&p_display_in_irish=N&p_refresh_search=Y
Employer: University of Oxford
Location: Oxford, England
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: September 28th, 2017
Applications close: October 19th, 2017
University of OxfordOxford, EnglandBA or BSALSSep 28, 2017
Research Specialist, Grossman Lab

Research Specialist, Grossman Lab

(Click title to open job details in a new window.)
Description:

A full-time position is available in the laboratory of Dr. Murray Grossman in the Department of Neurology at the University of Pennsylvania. This lab focuses on cognitive neuroscience and clinical questions relating to language, memory, and neurodegenerative disease (e.g., primary progressive aphasia, behavioral variant frontotemporal degeneration, Alzheimer’s). Applicant responsibilities will include the collection and analysis of PET scan data, and the collection and analysis of structural MRI data. This position will provide a strong foundation for individuals interested in continuing their education in graduate or medical school.


Link: https://main.hercjobs.org/jobs/10314223/research-specialist-a
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: BA or BS
Conditions: FTD
Job posted: September 26th, 2017
University of PennsylvaniaPhiladelphia, PABA or BSFTDSep 26, 2017
Research Associate, Svendsen Lab

Research Associate, Svendsen Lab

(Click title to open job details in a new window.)
Description:

The Svendsen Laboratory at the Cedars-Sinai Regenerative Medicine Institute is looking 1hr personnel to join our dynamic group. The incumbent should have an interest in the basic science of stem cells and neuroscience. By understanding how the cells grow and differentiate we will be able to produce a better cell for transplantation and develop techniques for disease modeling. The laboratory technician will, under the direction of the P1, lab manager and project scientist, assist in the conduct of research in Amyotrophic Lateral Sclerosis (ALS).


Working under direct supervision, the Research Associate I performs a variety of routine experimental protocols and procedures to support the objectives of one or more laboratory research projects in a specific area of research. Assists in general laboratory activities, including maintenance of reagents and stocking of supplies. Files and monitors documents. Keeps accurate and detailed records of experiments and results, Assists in the operation of specialized equipment and machinery. Observes safety standards and procedures. The Research Assistant 1 will be able to perform routine cellular, micro- and molecular biology procedures including, but not limited to Western, Northern blot, DNA/RNA, PCR. protein extraction, cell culture. Immunohistochemistry, and staining. This position does not have supervisory responsibilities.


Link: https://www.cedars-sinaimedicalcenter.apply2jobs.com/ProfExt/index.cfm?fuseaction=mExternal.showJob&RID=27365&CurrentPage=37
Employer: Cedars Sinai Medical Center
Location: Los Angeles, CA
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: September 21st, 2017
Cedars Sinai Medical CenterLos Angeles, CABA or BSALSSep 21, 2017

Industry

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
Sr. Clinical Scientist

Sr. Clinical Scientist

(Click title to open job details in a new window.)
Description:

The Sr. Clinical Scientist will work with the Medical Director functions of Early Clinical Development teams and provide scientific and clinical input into early stage clinical development programs. This role will work on cross-functional study teams for the design, execution, and monitoring of clinical trials, early clinical research studies, and/or external research projects, as well as assist with data interpretation and communication.. This individual will report directly into a Sr. Medical Director of Clinical Development or a Therapeutic Area VP and will interface directly with other functions including Clinical Development, Clinical Pharmacology, and Biomarkers.


Link: https://jobs.biogen.com/job/Cambridge-Sr_-Clinical-Scientis%2C-Neurodegeneration-and-Repair-Research-Unit-MA-02138/421188900/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD or PharmD
Conditions: NDG
Job posted: October 26th, 2017
BiogenCambridge, MAPhD or PharmDNDGOct 26, 2017
Sr. Associate Scientist, Neurobiology

Sr. Associate Scientist, Neurobiology

(Click title to open job details in a new window.)
Description:

The Neurodegeneration and Repair Research Unit is seeking a motivated and experienced scientist to join a group a cutting edge research group focused on the rapid progression of novel therapeutics for neurodegeneration. The successful candidate will join a highly productive team that has established robust in vivo and in vitro assays, in support of project and company drug discovery and development goals.


Responsibilities: The ideal candidate will perform primary neuronal cell culture, immunochemistry chemistry staining, and animal experiments relevant for neurological disorders. The candidate should be able to design, execute and troubleshoot experiments and to analyze and interpret results. Document and communicate work clearly and concisely, may participate in writing manuscripts, scientific reports, and patents.


Link: https://jobs.biogen.com/job/Cambridge-Sr-Associate-Scientist%2C-Remyelination-and-Repair%2C-Research-MA-02138/415533200/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: BA or BS
Conditions: NDG
Job posted: October 24th, 2017
BiogenCambridge, MABA or BSNDGOct 24, 2017
Director/Sr. Director, Neurodegeneration and Repair Research

Director/Sr. Director, Neurodegeneration and Repair Research

(Click title to open job details in a new window.)
Description:

We are looking for a talented leader to direct preclinical research in Dementia and Memory Disorders within the new Neurodegeneration and Repair Research Unit. In close partnership with the early clinical lead for within the same unit, the successful candidate will be responsible for delivering innovative drug candidates for proof-of-concept trials in AD, FTD and other memory disorders. He/she will lead the efforts of multiple research teams from early target discovery to late preclinical development and support the clinical trial strategy. We seek a candidate with knowledge of the biology of neurodegeneration and an outstanding track record in the field of drug development. He/she will succeed by collaborating closely with other Biogen scientists and clinicians in the areas of neurodegeneration, neuroimmunology and repair, as well as experts in the multiple therapeutic modalities – small molecules, antibodies, biologics, antisense oligonucleotides and gene therapy – in the Biogen portfolio. An innovative approach to biomarker and drug delivery strategies will also be required. We particularly seek candidates who have demonstrated strong scientific rigor while exploring novel pathways and mechanisms in humans and model systems and in leading multidisciplinary research teams. Demonstrated expertise in Alzheimer’s research and experimental models would be an advantage but is not required.


Link: https://jobs.biogen.com/job/Cambridge-DirectorSr_Director%2C-Neurodegeneration-and-Repair-Research-MA-02138/374546100/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD or PhD/MD
Conditions: FTD
Job posted: October 23rd, 2017
BiogenCambridge, MAPhD or PhD/MDFTDOct 23, 2017
Sr. Director, Clinical Research, Rare and Neurological Diseases

Sr. Director, Clinical Research, Rare and Neurological Diseases

(Click title to open job details in a new window.)
Description:

The Rare Disease Research Unit is looking for a talented senior physician scientist to join our team developing transformational new treatments in rare Neuromuscular, Neurodevelopmental and Neurodegenerative diseases using AAV gene therapy. This individual will focus on the challenging translational, clinical and regulatory problems presented by gene therapy in rare (often) pediatric indications, including natural history studies, novel endpoint development and clinical trial design. The candidate will be accountable for the delivery of translational and clinical development plans for AAV gene therapy programs in multiple rare neurological indications, and will be skilled in early clinical program design and conduct from pre-clinical stages to POC. Similar activities will be required for programs exploiting other treatment modalities. Experience and proven collaborative skills with basic and clinical scientists, investigators, regulators and safety functions are essential.


*Accountable for the development of translational and clinical development plans in rare Neuromuscular, Neurodevelopmental and *Neurodegenerative diseases using AAV gene therapy and other modalities for RDRU projects

*Lead interactions with colleagues in Global Product Development and Pfizer Innovative Health with regard to clinical development planning and product concept development for AAV gene therapies and other modalities.

*Partner with functions in Early Clinical Development as needed to ensure that biomarker and quantitative development plans are enabled in all relevant Rare Neuro programs to help determine early signs of efficacy and proof of concept, patient stratification, etc.

*Serve as a clinical champion for early development Rare Neuro programs in AAV gene therapy and other modalities

*Help to build, develop, and lead motivated and engaged matrix teams

*Provide oversight to clinical teams, including:

*Lead preparation of clinical sections of all relevant regulatory filings (IND, Orphan designation, Fast track and breakthrough designations – including NDA/BLA when required).

*Oversee management of studies and serve as expert on clinical and medical issues, including medical monitoring where necessary

*Oversee review of study data, including safety monitoring and SAE reporting

*Oversee writing of final study reports and preparation of documents for submission

*Establish and support relationships with external experts, consultants, key opinion leaders, to ensure implementation of latest clinical thinking and guidelines into clinical development plans and study designs

*Serve as medical and technical resource for clinical issues raised by internal and external collaborators, investigators, consultants and contractors

*Mentor or supervise other clinicians to expand drug development understanding and provide development opportunities

*Foster a transparent environment that encourages strong partnerships and mutual trust between teams, sub-teams, and therapeutic areas.

*Represent the company at scientific meetings and presentations, interactions with rare disease foundations, as well as other public relations opportunities

*Assist in the development of publications, abstracts, and presentations

*Support business development activities as needed, including due diligence activities.

*Maintain up-to-date knowledge of scientific and clinical published literature in relevant therapeutic areas including the key clinical development issues.


Link: https://pfizer.wd1.myworkdayjobs.com/en-US/PfizerCareers/job/USA---MA---Cambridge-Kendall-Sq-610-Main/SrDirector-ClinResClinicMD_1605538?source=Linkedin
Employer: Pfizer
Location: Cambridge, MA
Sector: Industry
Degree required: MD or MD/PhD
Conditions: NDG
Job posted: October 13th, 2017
PfizerCambridge, MAMD or MD/PhDNDGOct 13, 2017
Research Scientist

Research Scientist

(Click title to open job details in a new window.)
Description:

Inscopix is looking for a talented neuroscientist with a strong background working with rodent models of neurodegenerative disease who is interested in pursuing groundbreaking brain science in a highly-motivating and fast-paced entrepreneurial environment. You will have unique opportunities to work in close collaboration with an interdisciplinary team of driven neuroscientists, physicists, engineers, and data scientists. If you are looking for an opportunity that immerses you in 21st century neuroscience, we want to hear from you!


The ideal candidate will have:


*A PhD in Neuroscience or in a related field

*At least two years of postdoctoral research experience in academia or industry

*Experience with in vivo calcium imaging, optogenetics and/or electrophysiology

*Experience in translational and/or drug discovery research, including with disease models of neurodegeneration (e.g. Parkinson’s disease)

*Excellent surgical skills, including stereotaxic injections and/or implantations

*Familiarity with rodent behavioral assays

*Strong quantitative and analytical skills

*Creative problem-solving skills

*Excellent verbal and written communication skills

*A desire to work with amicable, highly knowledgeable, interdisciplinary teams

*A strong publication record


Bonus skills:


*Experience with nVista and/or nVoke technology

*Strong programming skills in a language such as Matlab or Python

*Experience with viral and transgenic technology

*Experience with immunohistochemistry and confocal microscopy


About Inscopix


Our flagship product for imaging large-scale neural circuit activity during behavior, nVista, provides neuroscientists with the ability to generate unprecedented data sets. In late 2016, we introduced our second-generation product, nVoke, combining the neural circuit imaging of nVista with optogenetic manipulation.


Link: http://neurojobs.sfn.org/jobs/10366543/research-scientist-neurodegenerative-disease
Employer: Inscopix
Location: Palo Alto, CA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: October 12th, 2017
InscopixPalo Alto, CAPhDNDGOct 12, 2017
Research Scientist, Protein Sciences

Research Scientist, Protein Sciences

(Click title to open job details in a new window.)
Description:

We are seeking a Scientist with expertise in protein expression, purification and analytical characterization to contribute to our drug discovery efforts.


Responsibilities:


*Implement a number of expression systems (including mammalian, insect and bacterial) to support small to large scale production of proteins and antibodies.

*Perform small-scale expression and purification screening and optimization for both secreted and cytosolic proteins.

*Develop cell lines expressing specific protein(s).

*Characterize expressed/purified proteins through in vitro analytical techniques including mass spectrometry.


Requirements:


*PhD in Biology, Biochemistry or a related field with 2+ years of relevant experience with antibody and protein expression, purification and characterization.

*Hands-on mammalian/baculoviral expression system experience is required.

*Proficiency with scaling cellular expression systems from 96-well to liter formats.

*Experience with creating stable cell lines.

*Ability to carry out mass spectrometry on proteins/peptides.

*Ability to work independently with minimal supervision while meeting timelines.

*Highly self-motivated with a strong sense of responsibility and a collaborative spirit.


Link: https://www.denalitherapeutics.com/careers/?gh_jid=252383
Employer: Denali Therapeutics
Location: San Francisco, CA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: October 10th, 2017
Denali TherapeuticsSan Francisco, CAPhDNDGOct 10, 2017
Research Scientist

Research Scientist

(Click title to open job details in a new window.)
Description:

We are looking for an experienced research scientist to join the Neuroscience department. The scientist will assume a hands-on role in a team responsible for an early drug discovery project for a neurodegenerative disorder. The scientist will conceive, conduct, and analyze experiments to identify and validate novel targets and low molecular weight modulators. In vitro and ex vivo models, including hPSC-derived neuronal platforms, and other molecular and cell biology techniques, will be heavily utilized within projects. Excellent communication and teamwork will be critical.


Minimum requirements The candidate will have a B.S. or M.S. degree or equivalent in biochemistry, neuroscience, cell biology, or a similar discipline with at least three years of industrial or academic research experience. The candidate will ideally have familiarity with iPS / ES cell research and cell-based assay development including phenotypic profiling by high-content imaging. The candidate must be highly collaborative, self-motivated, team-oriented, and have excellent communication and computer skills. Deep expertise in some of the techniques listed below is required, with an expectation that the candidate will develop any new technical skill as needed to answer the biological question at hand.


•Pluripotent stem cell culture and differentiation.

•Immunofluorescence techniques, including modern high-content imaging and computational image analysis to extract phenotypic data from complex cultures.

•High throughput cell-based screening.

•Molecular biology, including cell line engineering by CRISPR/CAS9, introduction of reagents into neurons by viral transduction or transfection and biochemical assay development.


Link: https://sjobs.brassring.com/TGWEbHost/jobdetails.aspx?partnerid=13617&siteid=5268&Areq=224554BR&codes=13335
Employer: Novartis
Location: Cambridge, MA
Sector: Industry
Degree required:
Conditions: NDG
Job posted: October 9th, 2017
NovartisCambridge, MANDGOct 09, 2017
Scientist I, ALS

Scientist I, ALS

(Click title to open job details in a new window.)
Description:

Neurology Research at Biogen seeks a highly motivated and experienced associate scientist to join the new initiative on ALS (amyotrophic lateral sclerosis). The Neurology department is responsible for discovery research on pathogenic mechanisms of neurodegenerative disorders and translating these findings into novel strategies for therapeutic intervention. The successful candidate will execute in vivo experiments to support the validation of novel drug targets and the development of small- and large-molecule drugs for the treatment of ALS. A major component of this work will be the assessment of drug candidates in a multiple rodent models, using a wide variety of morphological and functional endpoints, working closely with members of the ALS team as well as multiple internal and external collaborators. You will work in a fast paced, highly collaborative team environment at an exciting period for ALS research.


Link: https://jobs.biogen.com/job/Cambridge-Scientist-I%2C-ALS%2C-Neurodegeneration-and-Repair-MA-02138/418016000/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: ALS
Job posted: October 9th, 2017
BiogenCambridge, MAPhDALSOct 09, 2017
Research Scientist

Research Scientist

(Click title to open job details in a new window.)
Description:

We are currently seeking a highly motivated, experienced scientist to join the stem cell group in the Neuroscience department to aid in target discovery and validation in the areas of psychiatry and neurodegeneration.


Posting Title: Neuroscience Pluripotent Stem Cell Investigator/Scientist


Responsibilities:

•Develop hESC and hiPSC models and relevant phenotypic cell-based and biochemical assays to study neurodevelopmental, psychiatric, and neurodegenerative disorders

•Employ CRISPR technology to generate reporter cell lines and perform KO studies in PSC-derived neurons

•Analyze, interpret, and communicate scientific data

.

Minimum requirements The ideal candidate would have:

•A Ph.D. with 0-4 years of postdoctoral research experience or M.S. with 10+ years of research experience, a record of significant achievements in research, creativity, excellent communication and leadership skills, and the ability to work in a multidisciplinary, team-oriented environment

•A neuroscience background, with expertise in differentiating neuronal lineages from human pluripotent stem cells

•Experience in developing biochemical and cell-based functional assays, including protein-protein/protein-RNA interactions, high-content, calcium, and live-cell imaging

•Proficiency in cellular and molecular biology techniques, including qPCR, cloning, western blotting, immunofluorescence, and FACS

•Experience in genome engineering technologies and CRISPR or shRNA screening is a plus

•Experience in genomics, including analyzing RNA-seq and other omics data, is a plus

•The ability to work productively in a fast-paced environment that requires a high level of communication, collaboration, and organization


Link: https://sjobs.brassring.com/TGWEbHost/jobdetails.aspx?partnerid=13617&siteid=5268&Areq=224438BR&codes=13335
Employer: Novartis
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: October 7th, 2017
NovartisCambridge, MAPhDNDGOct 07, 2017
Senior Scientist, Neuroscience

Senior Scientist, Neuroscience

(Click title to open job details in a new window.)
Description:

As a Senior Scientist in Merck’s Neuroscience Department you will engage in exciting drug discovery research targeting the treatment of Neurodegenerative diseases. An expert in cellular and molecular biology, you will have the opportunity to work as part of a high profile team applying cutting edge cell biology techniques to identify, validate and progress innovative novel drug targets. You will design, implement and run biochemical and cell based assays to support our drug discovery efforts.


Responsibilities include but are not limited to:


– Build novel cellular models utilizing cell lines, primary neuronal cultures as well human iPSC-derived neurons that probe various biochemical and functional endpoints

– Use molecular, genetic, imaging and/or biochemical techniques to investigate relevant disease mechanisms in vitro and in vivo models

– Maintain awareness and implement technology that would enable scientific problem solving and/or improve efficiency

– Analyze, interpret and present data at group and departmental meetings and write internal documents on technical and scientific findings


Link: https://jobs.sciencecareers.org/job/463689/senior-scientist-biology-west-point-neuroscience-job/
Employer: Merck
Location: West Point, PA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: September 21st, 2017
MerckWest Point, PABS or MSNDGSep 21, 2017

Non-Profit and Government

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
Senior Scientist

Senior Scientist

(Click title to open job details in a new window.)
Description:

LifeArc is the new name for MRC Technology, a medical research charity with a 25 year legacy of helping scientists and organisations turn their research into treatments and diagnostics for patients. LifeArc is pioneering new ways to turn great science into greater patient impact. It brings together a network of partners to tackle specific diseases and directly funds academic and early stage research.


Our Centre for Therapeutics Discovery (CTD) in Stevenage operates at the interface between academic research and the drug discovery industry. We take novel academic targets and generate lead stage small molecules and therapeutic antibodies for indications with unmet medical need.


The Biology Group supports both small molecule and antibody projects, working closely with our Chemistry and Biotherapeutics Groups. We are looking for a Senior Scientist to provide support for our on-going drug discovery projects in the neuroscience disease area. You will be a Post-Doctoral Scientist with several years’ relevant laboratory experience in neurodegeneration and/or neuroinflammation with practical experience in relevant cell and molecular biology techniques, primary neuronal/glial culture and immune cell culture. Good knowledge of neurodegenerative disease and inflammatory pathways would be advantageous. It would be highly beneficial to have experience in drug discovery and line management although this is not essential.


As part of a project team and collaborating with internal and external scientists, you will independently design and perform target validation experiments and cell-based assays suitable for the profiling of compounds and/or antibodies. You should also be sufficiently experienced to lead on the scientific rationale and to propose novel avenues of research to progress the project. You are likely to be working on more than one project at any one time.


To apply please email your CV and covering letter explaining why you want to work for LifeArc to: recruitment@lifearc.org or by post to Recruitment, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX (electronic applications preferred).


Link: https://www.nature.com/naturejobs/science/jobs/628189-senior-scientist-biology
Employer: LifeArc (MRC Technology)
Location: Stevenage, England
Sector: Non-Profit
Degree required: PhD
Conditions: NDG
Job posted: October 30th, 2017
Applications close: November 17th, 2017
LifeArc (MRC Technology)Stevenage, EnglandPhDNDGOct 30, 2017
Director, Division of Neuroscience

Director, Division of Neuroscience

(Click title to open job details in a new window.)
Description:

The National Institute of Neurological Disorders and Stroke (NINDS) seeks a Director to lead its extramural Division of Neuroscience. The Director of the Division of Neuroscience will be responsible for planning and directing a program of extramural and collaborative research in neuroscience, guiding NINDS’s largest research portfolio and charting the future of a vibrant, growing neuroscience research community https://www.ninds.nih.gov/. The Director of the Division of Neuroscience will lead a group of approximately 60 professional staff. The research portfolio of the Division of Neuroscience includes an annual budget of over $1 billion dollars in grants and over $30 million in R&D contracts.


Applicants should submit a current curriculum vitae, bibliography, full contact details for three (3) references, and prepare two statements: a vision statement and a statement that addresses the specific qualification requirements (please limit each statement to two pages) to Joanne Pomponio jpomponio@ninds.nih.gov. Review of applications will begin on December 15, 2017 and applications will continue to be accepted and considered until the position is filled. You may contact David Shurtleff, Ph.D., Search Committee Chair, with questions and for more information about this vacancy at dshurtle@mail.nih.gov or (301) 435-0891.


Link: https://jobs.sciencecareers.org/job/467867/ninds-director-division-of-neuroscience-nih-ninds-/
Employer: NINDS
Location: Bethesda, MD
Sector: Non-Profit
Degree required: PhD or MD
Conditions: NDG
Job posted: October 20th, 2017
NINDSBethesda, MDPhD or MDNDGOct 20, 2017
Associate Scientist

Associate Scientist

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Description:

The ALS Therapy Development Institute (ALS TDI) has an opening for a full-time Associate Scientist working in the Translational Research group. The Associate Scientist will be part of the team working to develop patient-derived induced pluripotent stem cell (iPSc) collection, as well as the development and implementation of cell-based high content screens for target and drug discovery.


Responsibilities include but are not limited to:


*Isolation and banking of patient-derived primary cells

*Generating and characterizing of iPSc and their differentiated derivatives

*Assisting in the development and characterization of isogenic genome-edited and patient-derived cell-based screening models


Link: https://www.idealist.org/en/job/4ff78fc67b4f4e5cb85abfb28af732b9-associate-scientist-als-tdi-cambridge?
Employer: ALS Therapy Development Institute
Location: Cambridge, MA
Sector: Non-Profit
Degree required: BA or BS
Conditions: ALS
Job posted: October 16th, 2017
Applications close: November 20th, 2017
ALS Therapy Development InstituteCambridge, MABA or BSALSOct 16, 2017
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