Figure 1B Amplitude of low frequency fluctuation  (ALFF) differences between ALS and control groups without grey matter (GM) correction (A) and with GM correction (B).
Image credit: Luo, et.al. 2012 under CC BY license

Job Opportunities

To submit any new job opportunities for this list, please email ALSjobs@prize4life.org. List the employer, location, closing date if applicable, and a link to more information. Jobs are removed after 3 months, unless requested otherwise.

This free job bulletin board aims to help scientists identify job opportunities in the field of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Positions described as broadly spanning neurodegenerative diseases (NDG) are noted as ‘NDG‘. The job listing includes research positions at all levels, as well as non-research positions for which a research background at the MS, PhD, or MD level is required.


Click the title of any table column to sort.

Academia

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Assistant, Associate or Full Professor

Assistant, Associate or Full Professor

(Click title to open job details in a new window.)
Description:

The Black Family Stem Cell Institute at the Icahn School of Medicine at Mount Sinai is seeking outstanding applicants (PhD or MD/PhD) for a full-time, potential tenured position at the rank of Assistant Professor, Associate Professor, or Professor. We are a well-established, state-of-the-art research program with a distinguished publication record in stem cell biology and regenerative medicine, laying the scientific groundwork for understanding and manipulating stem cell behavior and developing sophisticated strategies for modeling and treating diseases ranging from blood disorders to neurodegeneration. Preference will be given to outstanding candidates who can complement and enhance existing strengths within the Black Family Stem Cell Institute and work collaboratively with additional world-class researchers at sister institutes at Mount Sinai.


A culture of innovation and a passion for pushing the boundaries of knowledge are integral to all activities at Icahn School of Medicine at Mount Sinai, driving us on a daily basis to challenge existing limitations of science and medicine to create and discover what was previously thought to be impossible. Mount Sinai is at the heart of an exciting and innovative environment and is a friendly and collegial place to work. New York City offers an unrivaled array of cultural and recreational attractions.


Interested candidates should send a copy of their curriculum vitae, a brief letter outlining their interests and names of three references to Thomas Zwaka, MD, PhD thomas.zwaka@mssm.edu by June 1, 2017.


Link: http://jobs.sciencecareers.org/job/443315/black-family-stem-cell-institute-mount-sinai-new-york-full-time-potential-tenured-faculty-position/
Employer: Mount Sinai School of Medicine
Location: New York, NY
Sector: Academia
Degree required: PhD or MD/PhD
Conditions: NDG
Job posted: March 22nd, 2017
Applications close: June 1st, 2017
Mount Sinai School of MedicineNew York, NYPhD or MD/PhDNDGMar 22, 2017
NEW! Research Associate, Fraenkel Lab

Research Associate, Fraenkel Lab

(Click title to open job details in a new window.)
Description:

The research group of Professor Ernest Fraenkel seeks a talented scientist to participate in an unprecedented study of the neurodegenerative disease ALS. Working with researchers at clinical and academic institutions across the United States, we are gathering data on approximately 1,000 ALS patients and controls. Induced pluripotent stem cell (iPSC) lines are being derived from each individual and these are being used to generate motor neurons for a wide range of omic studies. Our collaboration seeks to identify different subtypes of the disease, identify correlations between molecular pathways and clinical symptoms, and propose therapeutic strategies.


The research associate will be responsible for generation of epigenomic data from these patient-derived iPSC lines; work closely with collaborators to coordinate the study; and work closely with in-house computational biology team, which is integrating omic and clinical data. Will take a leading role in deriving hypotheses from the computational analyses and designing follow up experiments, using the iPSC lines and post-mortem tissue.


Requirements:


Minimum of two years’ experience with next-generation sequencing technologies, especially ATAC-Seq and ChIP-Seq.

Experience with mammalian cell culture; experience with epigenetic methods and knowledge of neurobiology.

Experience with culturing induced pluripotent stem cells (IPSCs), CRISPR/Cas9 and RNA interference, basic skills in data management and statistical analysis, and high-throughput automation are preferred.

Apply:


For more information, and to apply please visit the MIT website (referencing job #14485) at: http://careers.mit.edu/


Link: https://www.linkedin.com/jobs/view/273974569/
Employer: MIT
Location: Cambridge, MA
Sector: Academia
Degree required: BS
Conditions: ALS
Job posted: March 20th, 2017
MITCambridge, MABSALSMar 20, 2017
NEW! Postdoctoral Fellow, Farese-Walther Lab

Postdoctoral Fellow, Farese-Walther Lab

(Click title to open job details in a new window.)
Description:

We have a postdoctoral position available in the laboratory of HHMI Investigator, Tobias Walther, Ph.D., and Robert V. Farese, Jr, M.D., who jointly run a highly collaborative group at the Harvard School of Public Health. The lab is located in the Boston Longwood medical campus and is affiliated with the Department of Genetics and Complex Disease (HSPH), the Department of Cell Biology (Harvard Medical School), the Broad Institute of MIT and Harvard, and the Howard Hughes Medical Institute.


The Walther-Farese Laboratory studies the biochemistry of cellular lipid metabolism and membrane homeostasis. We seek outstanding candidates with Ph.D. training in cellular and murine models of neurodegeneration. Projects are available in the areas of lyososome biology and frontotemporal dementia and in the area of altered sphingolipid homeostasis and neurodegenerative diseases.


Applicants should possess a Ph.D. or M.D./Ph.D. in cell biology or neurodegenerative disease research and have an outstanding publication record.


For Additional Information, Please Visit Our Webpages

https://faresewaltherlab.hms.harvard.edu/

http://cellbio.med.harvard.edu/people/faculty/farese-jr

http://cellbio.med.harvard.edu/people/faculty/walther

https://www.hhmi.org/scientists/tobias-c-walther


To Apply

Interested candidates should send a cover letter, Curriculum Vitae and three letters of reference to: robert@hsph.harvard.edu and tholmes@hsph.harvard.edu. Please include the position title, Postdoctoral Position – Cell Biology/Neurodegenerative Diseases, in the subject line.


Link: https://www.linkedin.com/jobs/view/272686325/
Employer: Harvard School of Public Health
Location: Boston, MA
Sector: Academia
Degree required: PhD or MD/PhD
Conditions: NDG
Job posted: March 16th, 2017
Harvard School of Public HealthBoston, MAPhD or MD/PhDNDGMar 16, 2017
NEW! Manager, Stem Cell Phenotypic Screening Facility

Manager, Stem Cell Phenotypic Screening Facility

(Click title to open job details in a new window.)
Description:

Applications are invited for an experienced postdoctoral biological scientist to work as a Stem Cell Research Manager to run the MRC DPUK Dementia Stem Cell Phenotypic Screening Facility undertaking target and drug discovery projects in patient stem cell-derived neuronal models of disease.


This is an exciting opportunity to work at the interface between academic research and pharmaceutical target and drug discovery to contribute to the development of novel therapeutics for neurodegenerative disease. The Facility uses induced pluripotent stem cell (iPSC) lines differentiated into defined neuronal populations to better understand the molecular mechanisms of Parkinson’s Disease (PD), Alzheimer’s disease (AD) and related neurodegenerative disorders.


Duties will include facilities management of a major new cluster of high-end equipment for drug and target discovery (Opera Phenix high-content imager; ECHO Nanodrop dispenser; automated robotic systems; high-throughput plate readers and a stem cell culture facility); manage budgetary systems; project management; staff supervision and training; develop new strategic alliances; monitor, evaluate and enhance the performance of the facility. Applicants must hold, or be near completion of, a PhD/DPhil in a relevant area of research, or have equivalent experience, and have expertise in cellular neuroscience, cell biology or imaging relevant to analysis of neuronal phenotypes.


The post is a collaborative project between the OPDC and the MRC UK Dementia Platform (DPUK) funded for up to 3 years and is available to start as soon as possible. The post will be based in the Laboratory of Molecular Neurodegeneration, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX.


Salary: Grade 7: £31,076 – £38,183 p.a.


Informal enquiries may be directed Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk).


The closing date for applications is 12.00 midday on Wednesday 12 April 2017. Interviews will be held on 26 April 2017.


Link: https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.display_form?p_company=10&p_internal_external=E&p_display_in_irish=N&p_applicant_no=&p_recruitment_id=128072&p_process_type=&p_form_profile_detail=&p_display_apply_ind=Y&p_refresh_search=Y
Employer: University of Oxford
Location: Oxford, England
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: March 13th, 2017
Applications close: April 12th, 2017
University of OxfordOxford, EnglandPhDNDGMar 13, 2017
Assistant, Associate or Full Professor, Neuroscience

Assistant, Associate or Full Professor, Neuroscience

(Click title to open job details in a new window.)
Description:

The Department of Neurology and Weill Institute for Neurosciences at UCSF invites applications from exceptional investigators at the level of Assistant, Associate or Full Professor who are well qualified to lead investigations of amyotrophic lateral sclerosis and other neurodegenerative disorders. The successful candidate will have developed a rigorous laboratory-based research program focused on the mechanisms and treatment of neurodegeneration and will have a track record of high-impact publications. Applicants must have an MD or PhD. Outstanding credentials as a clinician and clinical investigator will be considered additional strengths, although they are not required. The individual will work closely with other investigators at the Weill Institute of Neurosciences to translate key discoveries into clinical investigations and trials. This is a rare opportunity for an accomplished and highly motivated individual to join a growing team of investigators at the new Weill Institute for Neurosciences located at UCSF’s burgeoning Mission Bay campus.


Interested applicants are encouraged to apply online at https://aprecruit.ucsf.edu/apply/JPF01314


Link: https://aprecruit.ucsf.edu/apply/JPF01314
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: MD or PhD
Conditions: ALS
Job posted: March 9th, 2017
Applications close: May 22nd, 2017
University of CaliforniaSan Francisco, CAMD or PhDALSMar 09, 2017
Postdoctoral Fellow, Xu Lab

Postdoctoral Fellow, Xu Lab

(Click title to open job details in a new window.)
Description:

A postdoctoral position is available in Zuoshang Xu’s laboratory to study mechanism of motor neuron degeneration in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease.

PhD required. Candidates with strong interest in neurodegenerative disease and proficiency in molecular biology are encouraged to apply. Candidates with additional familiarity with cell culture, imaging analysis and genomics will be considered preferentially. PhD required. Candidates with strong interest in neurodegenerative disease and proficiency in molecular biology are encouraged to apply. Candidates with additional familiarity with cell culture, imaging analysis and genomics will be considered preferentially.


To Apply: Please forward CV to: Zuoshang.Xu@umassmed.edu


Link: https://www.linkedin.com/jobs/view/289237242/
Employer: University of Massachusetts Medical School
Location: Worcester, MA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: March 5th, 2017
University of Massachusetts Medical SchoolWorcester, MAPhDALSMar 05, 2017
Neuropathologist

Neuropathologist

(Click title to open job details in a new window.)
Description:

Applications are invited for the full time (10 PAs) post of Consultant Neuropathologist at Department of Clinical Neuropathology, King’s College Hospital NHS Foundation Trust. This a new post to join another 3 Consultant Neuropathologists to provide diagnostic service for neuroscience at King’s College Hospital NHS Foundation Trust and associated hospitals.


The successful applicant is expected to have full GMC registration and have completed their certified training in neuropathology. They should hold the FRCPath in neuropathology or its equivalent. Applicants should either be on the specialist register or a specialist registrar having or within 6 months of their expected date of receipt of CCT/CESR (CP) at time of interview.


The Department of Clinical Neuropathology at King’s College Hospital NHS Foundation Trust provides clinical diagnostic services for biopsies from brain tumours, muscle and nerve in addition to diagnostic services for neurodegenerative diseases at the Brain Bank for the Institute of Psychiatry, Psychology & Neuroscience (IoPPN). The successful candidate would be expected to have a record of working well in a team and take a full part in the diagnostic neuropathology rota.


The successful applicant will also be expected to be actively engaged in expanding services such as the small fibre neuropathy and molecular biology of brain tumours and also take the lead in teaching and training for neuropathology and neurosciences.


Any interested candidate would be strongly encouraged to visit the department prior to shortlisting.


To discuss the job application and arrange an informal visit please contact Professor Safa Al-Sarraj, Head of Clinical Neuropathology and Director of the Brain Bank on 0203299 1955/1950 or safa.al-sarraj@nhs.net.


Link: http://kings.healthjobsuk.com/job/v654044
Employer: King's College Hospital
Location: London, England
Sector: Academia
Degree required: Certified Neuropathologist
Conditions: NDG
Job posted: March 4th, 2017
Applications close: February 4th, 2017
King's College HospitalLondon, EnglandCertified NeuropathologistNDGMar 04, 2017
Postdoctoral Fellow, Storkebaum Lab

Postdoctoral Fellow, Storkebaum Lab

(Click title to open job details in a new window.)
Description:

We combine Drosophila and mouse genetics to study the molecular pathogenesis of the neurodegenerative disorders Charcot-Marie-Tooth neuropathy (CMT) and amyotrophic lateral sclerosis (ALS). The project that is offered will focus on the molecular mechanisms underlying CMT associated with mutations in tRNA synthetases, and is based on our recent publications in this field. Using Drosophila models for these diseases, we have identified a detailed molecular mechanism underlying the protein translation defect in motor and sensory neurons in vivo (unpublished). The proposed project involves the validation of this mechanism in mouse models, the most disease-relevant mammalian models currently available for these genetic disorders. If desired, the successful applicant could combine these studies with Drosophila genetic approaches. On the longer run, the development of an independent project that can be transferred to a future position is possible.


A broad spectrum of methods will be applied, all of which are well established in our lab, including mouse genetics, the recently developed FUNCAT technique, immunohistochemistry, several imaging techniques, molecular biology, protein biochemistry, and possibly also Drosophila genetics.


For further information please visit the Storkebaum lab website:

http://www.mpi-muenster.mpg.de/22108/storkebaum


Please send your application (with the position-code 02-2017), including motivation letter (up to one page), CV and the names of 2 referees via email to:


career@mpi-muenster.mpg.de


Max Planck Institute for Molecular Biomedicine

Roentgenstrasse 20

48149 Muenster

Germany


Link: http://www.nature.com/naturejobs/science/jobs/607393-postdoctoral-scientist
Employer: Max Planck for Molecular Biomedicine
Location: Münster, Germany
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: March 2nd, 2017
Applications close: March 19th, 2017
Max Planck for Molecular BiomedicineMünster, GermanyPhDALSMar 02, 2017
Postdoctoral Fellow, Xia Lab

Postdoctoral Fellow, Xia Lab

(Click title to open job details in a new window.)
Description:

A group of established investigators recently join the University of Central Florida (UCF) Medical College to form a competitive research team studying the mechanisms of neurodegeneration in amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). The team uses genetically engineered rats as a relevant model for the in vivo study of neurodegeneration associated with genetic mutations discovered by the team and by the other groups. Team members have documented findings in the journals including PLoS Genetics (2010 and 2011), the Journal of Clinical Investigation (2012), EMBO J (2013), PNAS (2013), and Acta Neuropath (2015). The team is funded by multiple NIH grants and has received supports from the UCF. The team invites experienced persons to join as a key member in the journey of discovery on disease mechanisms and therapies.


Post-doctors: Post-doctoral positions are immediately available to candidates who have experienced one or more of the following research activities: 1) characterizing transgenic or knockout mouse or rat models for neurological diseases; 2) characterizing protein-protein interaction with biochemical and molecular approaches; 3) studying synaptic function with molecular and physiological approaches; and 4) studying autophagy or proteasome dysfunction in disease conditions. Publication in a related field is required.


The University of Central Florida is located in Orlando of the sunny state Florida. The medical school is quite new and is rapidly growing. Interested persons are sincerely invited to apply for the positions. Please send cover-letter and CV to Dr. Xugang Xia at xugang.xia@ucf.edu


UCF is an equal opportunity/affirmative action employer. All qualified applicants are encouraged to apply, including minorities, women, veterans and individuals with disabilities. As a Florida public university, UCF makes all application materials and selection procedures available to the public upon request.


Contact Us: xugang.xia@ucf.edu


Link: http://neurojobs.sfn.org/jobs/8848751/post-doctoral-position-available-immediately
Employer: University of Central Florida
Location: Orlando, FL
Sector: Academia
Degree required: PhD, MD, MD/PhD
Conditions: ALS, NDG
Job posted: March 2nd, 2017
University of Central FloridaOrlando, FLPhD, MD, MD/PhDALS, NDGMar 02, 2017
Postdoctoral Fellow, Graff Lab

Postdoctoral Fellow, Graff Lab

(Click title to open job details in a new window.)
Description:

The project aims to use AD and frontotemporal dementia (FTD) patient derived cell models for genomic, transcriptomic and proteomic analyses in order to identify modifiers of disease onset. Fibroblasts from AD and FTD mutation carriers who have developed as well as escaped disease will be transfected with lentiviruses and converted to neurons in cell culture. Cell extracts of DNA, RNA and proteins will be harvested and analyzed at SciLife Lab. Retrieved data will be bioinformatically interrogated to find differences between cells derived from mutation carriers with disease and mutation carriers who have escaped disease i.e. cases of reduced penetrance. Validation of results will be performed on patient cerebrospinal fluid, serum and plasma as well as post mortem brain tissue. The position will be held in the Prof Graff research group called “Translational genetics of neurodegenerative diseases” which sits at the interface of clinical and experimental research. The research focus is on the genetics of FTD and AD and currently the group has about 10 members including professor, postdoc, PhD students and technicians. The group is also responsible for the Brain Bank at KI.


Duties

The postdoc candidate is expected to have a strong drive to pursue experimental research and bioinformatics analyses and have good communicative skills. The projects are pursued in collaboration with several research groups, and good collaborative skills are necessary as well as ability for independent work. Very good ability to speak and write English is also a requirement.


Entry Requirements

A person is eligible for a position as Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances. A PhD in biomedicine, cell biology, biotechnology or similar topic is required. The postdoc to be recruited needs to have strong experience of working with neuronal cell models, in particular using reprogramming and differentiation protocols, and a good knowledge of neurodegenerative diseases. Experience from bioinformatic –omics analyses, immuno-histochemistry and immunofluorescence methods and studies using lenti viruses for transfection of human cells is qualifying.


Further information

Please contact Prof. Caroline Graff (caroline.graff@ki.se, tel +46-733-839399) at the Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum, 141 57 Huddinge, Sweden for further information.


Application process

An employment application must contain the following documents in English or Swedish:

*A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work

*A complete list of publications

*A summary of current work (no more than one page)

*Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances


Link: https://ki.mynetworkglobal.com/se/what:job/jobID:138682/where:4/
Employer: Karolinska Institutet
Location: Huddinge, Sweden
Sector: Academia
Degree required: PhD
Conditions: FTD
Job posted: March 1st, 2017
Applications close: March 29th, 2017
Karolinska InstitutetHuddinge, SwedenPhDFTDMar 01, 2017
Postdoctoral Fellow, De Paola Lab

Postdoctoral Fellow, De Paola Lab

(Click title to open job details in a new window.)
Description:

A Postdoctoral Research Fellowship is available in the Laboratory of Synaptic plasticity and Repair of Imperial College London, starting immediately. The aim of this project is to gain new and fundamental insights into the cellular and molecular mechanisms that regulate the regeneration of adult neocortical circuits. We have previously demonstrated that certain populations of cortical neurons exhibit enhanced spontaneous regenerative capacity compared to others, and we are now interested in understanding the mechanisms responsible for this differential response to injury. Our goal is to develop effective strategies to enhance functional axon and synaptic regeneration (Holtmaat et al Nature protocols 2009; Canty et al Nature Communications 2013; Grillo et al Nature Neuroscience 2015).


We use an interdisciplinary approach and facilities accessible for this project include setups for combined electrophysiological and imaging studies, including five 2-photon microscopes, all optical stimulation and activity recordings in awake animals, light-sheet and super-resolution microscopes including SIM, PALM, STORM and STED.


London together with Cambridge and Oxford, only 1h train-ride away, represent one of the largest and most vibrant neuroscience communities in the world, with outstanding seminars and opportunities for collaboration. Imperial College London (ICL) is consistently rated among the world’s best universities with a reputation for excellence in neurotechnology and clinical neuroscience.


Requirements for the position: PhD or MD-PhD degree and strong publication record.


Required Expertise: Candidates with in vivo optogenetics, electrophysiology or calcium imaging experience will be preferred.


Applications, including CV, list of publications and statement of research interests should be sent to Dr. Vincenzo De Paola (v.depaola@lms.mrc.ac.uk). Applicants should arrange to have at least two confidential letters of reference sent by referees to this email.


Link: http://www.fens.org/News-Activities/Jobs/job-12203/
Employer: Imperial College London
Location: London, England
Sector: Academia
Degree required: PhD or MD/PhD
Conditions: NDG
Job posted: February 22nd, 2017
Imperial College LondonLondon, EnglandPhD or MD/PhDNDGFeb 22, 2017
Professor, Neurodegeneration (W3)

Professor, Neurodegeneration (W3)

(Click title to open job details in a new window.)
Description:

An der Medizinischen Fakultät der Universität Heidelberg ist im Rahmen der Entwicklung des Neurowissenschaftlichen Schwerpunktes eine W3-Professur für Neurodegeneration im Angestelltenverhältnis zu besetzen. Die Neurologische Klinik in Heidelberg hat das Ziel, neben den international sichtbaren Schwerpunkten Vaskuläre- und Intensivneurologie sowie Neuroonkologie und Neuroimmunologie einen innerhalb der Fakultät und am Standort Heidelberg integrierten Schwerpunkt für Neurodegeneration wissenschaftlich und klinisch zu entwickeln.


Übergeordnetes Ziel der W3-Professur ist die Entwicklung eines attraktiven grundlagenwissenschaftlichen und/oder anwendungsorientierten Forschungs-programms in einem der zentralen Bereiche der Neurodegeneration sowie Integration des Forschungsgebiets in die vorhandenen grundlagenwissenschaftlichen und translationalen Wissenschaftsschwerpunkte der Klinik und Fakultät. Klinisch soll eine verantwortliche, hoch spezialisierte Betreuung von Patienten mit den genannten neurodegenerativen Erkrankungen aus der Region und zunehmend im Sinne eines überregionalen Referenzzentrums erfolgen. Dabei ist nicht primär an dementielle Erkrankungen gedacht. Klinisch-wissenschaftlich sollte eine hohe Expertise in der Initiierung, Durchführung und dem Qualitätsmanagement klinischer, vor allem durch Wissenschaftler initiierter Studien bestehen, die mit Unterstützung vom Institut für Medizinische Biometrie und Informatik (IMBI) und dem Koordinierungszentrum für Klinische Studien (KKS) durchgeführt werden.


Einstellungsvoraussetzungen sind ein abgeschlossenes Hochschulstudium der Medizin, die Anerkennung als Facharzt/-ärztin für Neurologie, Promotion, Habilitation oder äquivalente Leistungen. Neben einer wissenschaftlichen Ausbildung und einem hochkarätigen Oeuvre sollten die Bewerberinnen und Bewerber über internationale Forschungserfahrung verfügen, nachgewiesen durch internationale Kooperationen mit namhaften Forschungsgruppen. Außerdem sollte einschlägige Vorerfahrung im Einwerben und Durchführen auch größerer Drittmittelprojekte mitgebracht werden.


Auf die weiteren in § 47 und § 48 Abs. 2 des baden-württembergischen Landeshoch-schulgesetzes genannten Einstellungsvoraussetzungen wird hingewiesen.


Die Universität Heidelberg strebt eine Erhöhung des Anteils der Frauen im wissenschaftlichen Personal an und fordert qualifizierte Frauen nachdrücklich auf, sich zu bewerben. Schwerbehinderte werden bei gleicher Qualifikation bevorzugt eingestellt.


Bitte richten Sie Ihre Bewerbung bis zum 15. März 2017 an Prof. Dr. W. Herzog, Dekan der Medizinischen Fakultät Heidelberg, Im Neuenheimer Feld 672, 69120 Heidelberg. Ihre Bewerbungsunterlagen sollten den Kriterien entsprechen, welche Sie auf der Webseite der Fakultätsgeschäftsstelle unter http://www.medizinische-fakultaet-hd.uni-heidelberg.de/professur einsehen können.


Link: https://karriere.klinikum.uni-heidelberg.de/index.php?ac=jobad&id=3535
Employer: University of Heidelberg
Location: Heidelberg, Germany
Sector: Academia
Degree required: MD (or equivalent), Neurology
Conditions: NDG
Job posted: February 7th, 2017
Applications close: March 15th, 2017
University of HeidelbergHeidelberg, GermanyMD (or equivalent), NeurologyNDGFeb 07, 2017
Postdoctoral Fellow, Gao Lab

Postdoctoral Fellow, Gao Lab

(Click title to open job details in a new window.)
Description:

A postdoctoral position is immediately available in the laboratory of Dr. Fen-Biao Gao at the University of Massachusetts Medical School to study molecular pathogenic mechanisms of fronototemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).


PhD required. Candidates with strong research experience in stem cell biology or molecular and cellular biology are encouraged to apply. Two years’ experience with cell culture (primary and cell lines), stem cell/neuronal differentiation preferred.


To Apply: Please forward CV to: Fen-Biao.Gao@umassmed.edu.


Link: http://www.nature.com/naturejobs/science/jobs/605061-postdoctoral-position
Employer: University of Massachusetts Medical School
Location: Worcester, MA
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: February 3rd, 2017
University of Massachusetts Medical SchoolWorcester, MAPhDALS, FTDFeb 03, 2017
Research Assistant Professor, Beal Lab

Research Assistant Professor, Beal Lab

(Click title to open job details in a new window.)
Description:

A full-time faculty position at the level of Instructor or Research Assistant Professor of Neuroscience is available in the Beal laboratory for Neurodegenerative Diseases. This is a research-focused position and a successful candidate will be expected to develop an externally funded research program with a focus on neurodegenerative disorders, particularly Huntington’s disease.


The successful candidate must hold a Ph.D. in Biology, Neuroscience, molecular biology, or in a related interdisciplinary field and have competitive research qualifications, including a track record of publication in top tier journals. The candidate should have at least 5 years of experience in in neuroscience, particularly in the area of neurodegeneration using cell and animal models. Candidates should be proficient in rodent husbandry, dissection and surgery, behavioral tests, stereotactic injections, histology, immunocytochemistry, and general cell and molecular biology techniques. We especially encourage applicants who have experience working with transgenic models of neurodegenerative diseases, such as mouse models for Huntington’s disease.


The individual chosen for this position will be encouraged to develop an extramurally-funded research program to support his or her research, to collaborate with members of the Department in their own research activities, and will be expected to participate in academic and service functions of the Department.


Application Instructions


Interested candidates should submit the following materials as a single PDF file: (1) a brief cover letter; (2) a curriculum vitae; (3) and contact information of three professional references by email to: fbeal@med.cornell.edu or vit2013@med.cornell.edu, to the attention of:


Dr. M. Flint Beal

University Professor

Professor of Neurology and Neuroscience

Brain and Mind Research Institute

Weill Cornell Medicine

New York, N.Y.


This position will remain open through April 1, 2017.


Link: http://neurojobs.sfn.org/jobs/8778822/faculty-position-neurodegenerative-diseases-huntington-s-disease
Employer: Weill Cornell Medical College
Location: New York, NY
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: February 2nd, 2017
Applications close: April 1st, 2017
Weill Cornell Medical CollegeNew York, NYPhDNDGFeb 02, 2017

Industry

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Associate Scientist III, Neuroimmunology

Associate Scientist III, Neuroimmunology

(Click title to open job details in a new window.)
Description:

The Biogen Department of Neuro/Immunology seeks a highly motivated and keen associate scientist whose primary responsibility is to advance target validation, drug discovery and development. The individual is expected to have mastered a broad range of experimental techniques, preferably having established expertise in the field of neuroimmunology. The individual will be expected to perform with significant independence with respect to designing and executing controlled experiments, analyzing and interpreting results, establishing and executing existing or new protocols/methodologies and recommending modifications. The individual is expected to read pertinent literature and exhibit knowledge of molecular and biological processes, applying their knowledge to propose new ideas and regularly make suggestions for creative solutions to technical challenges. The individual is expected to have strong written and verbal communication skills, preparing and delivering oral presentations, posters, draft research reports and contributing to manuscripts.


Responsibilities include:


•Driving target validation efforts for neurodegenerative diseases such as Alzheimer’s, Parkinson’s and ALS, with a particular focus on glial cells and neuroinflammation.


•Using a wide array of techniques relevant to neuroimmunology and glial cells


•Leveraging animal models of neuroinflammation and neurodegeneration to demonstrate proof-of-biology; knowledge and experience with such models is preferred.


•Designing and executing experimental plans, performing rigorous analysis and interpretation of experiments.


•Collaborating with relevant individuals and groups to advance projects; demonstrating good lab citizenship.


• Skilled experimentation encompassing a wide array of in vitro and in vivo techniques; relatively independent design, execution, analysis and interpretation of experiments.


• Strong oral and written presentation of technical work


• Collaboration with relevant individuals and groups to advance projects; demonstration of good lab citizenship.


Link: https://jobs.biogen.com/job/Cambridge-Associate-Scientist-II%2C-Research-MA-02138/376780100/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: ALS
Job posted: March 17th, 2017
BiogenCambridge, MABS or MSALSMar 17, 2017
NEW! Senior Associate Scientist, Neuroimmunology

Senior Associate Scientist, Neuroimmunology

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Description:

The Neuroimmunology department at Biogen is searching for a committed, enthusiastic and dependable associate scientist to assist with the design, execution and interpretation of preclinical studies for drug discovery and development. The incumbent will be part of a multifunctional team with responsibility for target validation and evaluation of novel drug candidates for neurodegenerative/neuroinflammatory diseases. He/she should be able to plan and execute in vivo and in vitro experiments with high level of independency, organization and scientific rigor. He/she should be able to maintain an up-to-date knowledge of pertinent literature and possess excellent communication and interpersonal skills to efficiently present results to project team members.


Link: https://jobs.biogen.com/job/Cambridge-Associate-Scientist-II%2C-Research-MA-02138/371072000/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: March 15th, 2017
BiogenCambridge, MABS or MSNDGMar 15, 2017
Principal Investigator, Laboratory of Neuronal Cell Biology

Principal Investigator, Laboratory of Neuronal Cell Biology

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Description:

As Principal Investigator for the Laboratory of Neuronal Cell Biology (LNCB), he or she will be:


•Responsible for converting new science into new targets, drug discovery programs, and technology programs for the Biogen portfolio with an emphasis on neurological disease.


•Accountable for building and advancing new neurobiology within a group of dedicated postdoctoral fellows and technicians.


•Contributes to developing and executing research strategies to deliver against Biogen’s objectives to engage in quality science that leads to a deeper understanding of targets and enables the research imperative of “choose the right targets”.


•Supports the Head of R&D (who also serves as Director for the LNCB) in defining basic and applied biology, molecular pharmacology, cellular biology, and in vivo neurobiological programs that augment the Biogen portfolio.


•Manages the day-to-day operations of the LNCB providing support and direction to the postdoctoral fellows and technician(s) in the lab.


•Accountable for people agenda in the LNCB including colleague development, reward and recognition, recruitment and retention, and communication.


•Builds external recognition for team through high impact publications.


ROLE RESPONSIBILITIES


• Single point of accountability for the functioning and delivery of the LNCB for projects assigned to his/her team. Able to ensure the lab can optimally utilize the resources available.


• Models expectations of quality, innovative science applied to discovering new medicines, and of effective people leadership and talent development.


• Builds cross-functional projects that cut across disciplines, including chemical biology, molecular and cell biology, cellular screening, and in vivo pharmacology.


• Engages the external environment through thought leadership and visible and active engagement with key opinion leaders, funding bodies, professional societies, and academic institutions and publishing of scientific work


• Partners with Biogen research leaders in the development of key talent within and across the Biogen laboratories.


• Able to effectively identify and advance breakthrough science.


• Consistently converts new science into new targets, drug discovery programs, and technology platforms for the Biogen portfolio.


• Able to maximize the value from an academic-style lab group in the midst of the discovery organization, aligned with therapeutic interests, but empowered to explore new biology through access to technologies and collaborations with existing groups.


• Works closely with individuals across Biogen Research Laboratories


• Manage, create, and leverage technologies to prosecute state-of-the-art research on novel pathways and targets.


• Effectively communicate proposed and completed research through presentations and publications both internally and externally.


• Lead and support research platforms in primary neuron culture, brain slices preparations, and in vivo rodent models.


• Connects LNCB science to Biogen platforms in structural biology, medicinal chemistry, screening, genetics, computational modeling, bioinformatics, veterinary sciences, pharmacokinetics/metabolism, and protein engineering.


• Ensure team access to reagents, data analysis, and technical resources across Biogen Research.


• Drives scientific excellence on projects that transform drug discovery efforts in the Biogen portfolio; ensures high impact publications.


• In addition to responsibilities over the LNCB, the Sr. Scientist will be responsible for building target class platforms that support discovery programs across the Biogen portfolio and particularly for neurodegenerative diseases. Target class platforms refer to broad classes of receptors, enzymes, or related macromolecules for which all necessary reagents, assays, screening systems, quantitative read-outs, and in vivo models are elaborated in a highly scaled and industrialized fashion. Examples include GPCRs, serine hydrolases, transporters, etc.


• The Sr. Scientist will further assume broad responsibility for new target identification that supports new programs that enter in the Biogen portfolio, and contributes to a sustainable pipeline of first-in-class programs. New targets will be rooted firmly in human biology and human genetics, and he/she will leverage ongoing work by postdoctoral fellows and others within the LNCB to provide 10-15% of the new targets pursued by Biogen.


Link: https://jobs.biogen.com/job/Cambridge-Sr-Scientist%2C-Laboratory-of-Neuronal-Cell-Biology%2C-Research-MA-02138/347661800/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD or MD/PhD
Conditions: NDG
Job posted: March 9th, 2017
BiogenCambridge, MAPhD or MD/PhDNDGMar 09, 2017
Scientist I/II, Translational Sciences

Scientist I/II, Translational Sciences

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Description:

The Biogen Department of Neuro/Immunology seeks a highly motivated and keen associate scientist whose primary responsibility is to advance target validation, drug discovery and development. The individual is expected to have mastered a broad range of experimental techniques, preferably having established expertise in the field of neuroimmunology. The individual will be expected to perform with significant independence with respect to designing and executing controlled experiments, analyzing and interpreting results, establishing and executing existing or new protocols/methodologies and recommending modifications. The individual is expected to read pertinent literature and exhibit knowledge of molecular and biological processes, applying their knowledge to propose new ideas and regularly make suggestions for creative solutions to technical challenges. The individual is expected to have strong written and verbal communication skills, preparing and delivering oral presentations, posters, draft research reports and contributing to manuscripts.


Link: https://jobs.biogen.com/job/Cambridge-Scientsit-III%2C-Translational-Sciences-MA-02138/384302200/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: NDG
Job posted: March 9th, 2017
BiogenCambridge, MABS or MSNDGMar 09, 2017
Director/Senior Director of Neurodegeneration and Repair Research

Director/Senior Director of Neurodegeneration and Repair Research

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Description:

We are looking for a talented leader to direct preclinical research in Dementia and Memory Disorders within the new Neurodegeneration and Repair Research Unit. In close partnership with the early clinical lead for within the same unit, the successful candidate will be responsible for delivering innovative drug candidates for proof-of-concept trials in AD, FTD and other memory disorders. He/she will lead the efforts of multiple research teams from early target discovery to late preclinical development and support the clinical trial strategy. We seek a candidate with knowledge of the biology of neurodegeneration and an outstanding track record in the field of drug development. He/she will succeed by collaborating closely with other Biogen scientists and clinicians in the areas of neurodegeneration, neuroimmunology and repair, as well as experts in the multiple therapeutic modalities – small molecules, antibodies, biologics, antisense oligonucleotides and gene therapy – in the Biogen portfolio. An innovative approach to biomarker and drug delivery strategies will also be required. We particularly seek candidates who have demonstrated strong scientific rigor while exploring novel pathways and mechanisms in humans and model systems and in leading multidisciplinary research teams. Demonstrated expertise in Alzheimer’s research and experimental models would be an advantage but is not required.


Link: https://jobs.biogen.com/job/Cambridge-DirectorSr_Director%2C-Neurodegeneration-and-Repair-Research-MA-02138/374546100/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD or PhD/MD
Conditions: FTD
Job posted: March 5th, 2017
BiogenCambridge, MAPhD or PhD/MDFTDMar 05, 2017
Research Associate, Proteomics

Research Associate, Proteomics

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Description:

Job description


BERG is seeking a highly motivated individual to join our rapidly expanding “Omics” division, reporting to the Chief Precision Medicine Officer. The successful candidate will join a team responsible for biomarker discovery/validation in multiple disease areas, including neurodegenerative diseases, diabetes, obesity, and cancer, using state-of-the-art quantitative proteomics platforms.


Responsibilities:


*Assist in high-throughput sample preparation of valuable clinical samples in a team-oriented environment

*Follow standard operating procedures and perform duties in a highly detail-oriented and organized manner

*Maintain, operate, and troubleshoot chromatography and mass spectrometry equipment

*Analyze and QC data to ensure optimal instrument performance and quality of sample preparation

*Assist in method development of novel sample preparation techniques as well as optimization of existing sample preparation pipeline


Qualifications:


*Requires a BS in chemistry, biochemistry, or related discipline with solid training in analytical methods plus 3-5 years of industry or independent research experience

*Hands-on experience with operating and maintaining chromatography and mass spectrometry instruments is required; experience with HR/AM mass spectrometers such as Thermo Orbitrap and Q-Exactive series is a plus

*Hands-on experience with mass spec data, quantitative and qualitative data analysis including spectral interpretation, and statistics-based data analysis is a plus

*Familiarity with high-throughput quantitative methodologies such as iTRAQ®, TMT®, and Label-free approaches is a plus

*Excellent communication and interpersonal skills combined with superior and proven track record of technical and organizational skills. Must be able to work in a team-oriented environment and demonstrate attention to detail and record keeping

*Knowledge of Microsoft Word, Excel, and PowerPoint required


Link: https://www.linkedin.com/jobs/view/262276617/
Employer: Berg Health
Location: Framingham, MA
Sector: Industry
Degree required: BS
Conditions: NDG
Job posted: February 28th, 2017
Berg HealthFramingham, MABSNDGFeb 28, 2017
Scientist, Neuroscience

Scientist, Neuroscience

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Description:

Genentech is inviting applications for a Scientist position (rank equivalent to assistant professor in academia) in the Department of Neuroscience. We are seeking an exceptional, highly motivated and creative scientist to lead innovative research efforts focused on unraveling the mechanisms of neurodevelopment and/or brain function in the context of nervous system diseases. He/she will also be expected to participate in inter-disciplinary teams to identify novel drug targets and discover new drugs to treat nervous system disorders. The ideal candidate will have significant experience in molecular and cellular biology using both in vitro and in vivo model systems, and possess a deep mechanistic understanding of the cellular pathways that contribute to diseases of the nervous system (e.g. neurodegenerative diseases). A solid track record of publications in top tier journals is required as is exceptional communication skills. The position will involve close collaboration with other research labs in Neuroscience as well as investigators in areas such as human genetics, bioinformatics, proteomics, imaging, and small molecule and large molecule drug discovery. The successful candidate will be expected to publish their research in high quality journals.


As a strong candidate, you will have:

PhD with postdoctoral research experience in cell biology, neuroscience or related areas in life sciences.

Record of impactful research in molecular cellular biology, neuroscience, or related fields, as evidenced by recent first authored publications in top-tier journals.

Excellent written and oral communication skills

The drive and ability to lead an independent research group and collaborate with other investigators

Outstanding promise of future scientific achievement


Link: https://www.gene.com/careers/detail/3398510619/Scientist-Neuroscience-Genentech-Research
Employer: Genentech
Location: San Francisco, CA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: February 23rd, 2017
GenentechSan Francisco, CAPhDNDGFeb 23, 2017
Research Scientist

Research Scientist

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Description:

AC Immune is seeking a highly qualified Research Scientist to expand the

company’s efforts in research. The candidate must possess scientific

background in structural biophysics and protein dynamics in

neurodegenerative diseases and a clear record of accomplishment in an

academic or a commercial setting. S/he must have demonstrated their ability

to make significant discoveries in an academic setting or bring a research

product to a clinical stage.


· Provides hands-on research support for the Biology research team within

the Biology department working on the discovery and characterization of

PET radiotracers for the diagnosis of neurodegenerative disorders

· Preparation and characterization of human brain tissue for binding studies

· Evaluation of new procedures and protocols for the enrichment of

pathological protein aggregates from human tissues (e.g.

immunoprecipitation, sucrose gradient, FACS)

· Optimization of binding assays or other quantitative assays for Kd and Ki

assessment

· Setting up autoradiography assay conditions for new radioligands on

human and TG mouse tissue sections

· Screening small molecule compounds that are regularly synthesized by the

Chemistry team using new as well as established assays

· Immunostaining of human tissue sections

· Evaluating target engagement of compounds by direct staining on tissue

sections

· Autoradiography with tritiated ligands


The candidate should have the following qualifications:

· Ph.D. training in life sciences

· Previous experience in structural biophysics and protein dynamics

· Previous experience in neuroscience and neurodegenerative disorders,

notably ALS and FTD along with TDP-43, is an advantage

· Postdoctoral experience is an advantage

· Excellent organizational skills and capability of data documentation

· Team spirit paired with autonomous and rigorous work style

· Excellent oral and written skills in English is mandatory


Link: http://www.alsresearchforum.org/wp-content/uploads/Research-Scientist_RS2.pdf
Employer: AC Immune
Location: Lausanne, Switzerland
Sector: Industry
Degree required: PhD
Conditions: ALS, FTD
Job posted: February 16th, 2017
AC ImmuneLausanne, SwitzerlandPhDALS, FTDFeb 16, 2017

Non-Profit and Government

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
Postdoctoral Fellow

Postdoctoral Fellow

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Description:

The lab for microRNA Models of Neurodegenerative Disease at the Institute of Molecular and Cell Biology is seeking to recruit a highly motivated Research Fellow to investigate pathogenic pathways underlying neurodegeneration linked to loss of microRNA function.


The work will involve both in vitro and in vivo techniques, including cellular and molecular biology, generation and analysis of transgenic flies, behavioral assays, tissue dissections, immunohistochemical analysis and confocal microscopy.


Link: https://app.a-star.edu.sg/astarcareerportal/JobDetails.aspx?enc=3vkpCJvkbXG9htc1jP6XN2YRHzaq8etMxCfagUGjmvPLZCdlfU4J+cqPBbpC0sKS2FmeT8ro/x5Sx/HnvQ8vaaPy/mASrXZbwgIybvd3vuE=
Employer: A*Star
Principal investigator: Institute of Molecular and Cell Biology
Location: Singapore
Sector: Non-profit
Degree required: PhD
Conditions: NDG
Job posted: February 7th, 2017
A*StarSingaporePhDNDGFeb 07, 2017
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