Figure 3. HNF-6 is required for proper morphology of the neuromuscular junction.
Image credit: Audouard, et.al. 2012 under CC BY license

Job Opportunities

To submit any new job opportunities for this list, please email ALSjobs@prize4life.org. List the employer, location, closing date if applicable, and a link to more information. Jobs are removed after 3 months, unless requested otherwise.

This free job bulletin board aims to help scientists identify job opportunities in the field of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Positions described as broadly spanning neurodegenerative diseases (NDG) are noted as ‘NDG‘. The job listing includes research positions at all levels, as well as non-research positions for which a research background at the MS, PhD, or MD level is required.


Click the title of any table column to sort.

Academia

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Chair, Neurodegenerative Disorders

Chair, Neurodegenerative Disorders

(Click title to open job details in a new window.)
Description:

The Kam Ling Barbara Lo Chair in Neurodegenerative Disorders will be situated at the Brain and Mind Centre of the University of Sydney, a pre-eminent multidisciplinary facility at the forefront of brain and mind sciences. The successful applicant will provide academic leadership in basic neuroscience with translational links to clinical neuroscience, particularly in neurodegenerative and dementia research. The successful candidate may bring particular experience in the realm of inflammation, genetics, animal or cellular models, particularly in relation to large-scale neurodegenerative and dementia-related research programs currently underway at the Brain and Mind Centre.


All applications must be submitted via the University of Sydney careers website. Visit sydney.edu.au/recruitment and search by reference number 1569/0817 (The Kam Ling Barbara Lo Chair in Neurodegenerative Disorders) for more information and to apply.


Employer: University of Sydney
Location: Sydney, Australia
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: December 11th, 2017
Applications close: January 31st, 2018
University of SydneySydney, AustraliaPhDNDGDec 11, 2017
NEW! Assistant or Associate Professor, Neuroscience

Assistant or Associate Professor, Neuroscience

(Click title to open job details in a new window.)
Description:

We are seeking individuals with research interests that complement our existing programs related to biological mechanisms and modeling of neurodegenerative diseases. Of particular interest are programs with a focus on Alzheimer’s Disease, Frontotemporal Dementia, and Parkinson’s Disease. Candidates with expertise and documented productivity in research areas that include investigation of how unfolded protein responses contribute to these diseases, with particular focus on tauopathies, are preferred. Candidates must have a desire to expand the educational landscape of the Department of Neuroscience through teaching and research training program development.


The successful candidate is expected to have a sustained track record for securing extramural funding and a strong publication record. Applicants will be expected to maintain strong research programs with evidence of continued extramural support and publications, and to demonstrate a commitment to excellence in teaching and mentoring graduate and medical students.


Applicants should submit a single PDF with curriculum vitae, a brief description of research interests, and names and contact information of three references.


Link: https://www.startwire.com/jobs/gainesville-fl/assistant-associate-professor-neuroscience-34659873
Employer: University of Florida
Location: Gainesville, Florida
Sector: Academia
Degree required: PhD
Conditions: FTD
Job posted: December 8th, 2017
University of FloridaGainesville, FloridaPhDFTDDec 08, 2017
NEW! Research Specialist, Southworth Lab

Research Specialist, Southworth Lab

(Click title to open job details in a new window.)
Description:

The Institute for Neurodegenerative Diseases (IND) at UCSF, Mission Bay Campus is seeking a Specialist for full-time work to perform and manage research activities in biochemistry and structural biology. The position is in the laboratory of Dr. Daniel Southworth and will support research efforts using cryo-electron microscopy to determine 3D structures of important biological macromolecules associated with human neurodegenerative diseases. Highly motivated candidates capable of independent problem solving and teamwork are encouraged to apply. This position will be part of a collaborative environment with access to state-of-the-art facilities in the Sandler Neurosciences Building on the UCSF Mission Bay campus. A successful candidate will be hired at the Junior, Assistant, or Associate Specialist rank commensurate with experience and qualifications.


Duties Include:

• Perform molecular cloning, protein expression, cell culture and protein purification experiments.

• Participate in lab meetings and multidisciplinary collaborations.

• Maintain chemical inventory and ensure lab compliance with health and safety.

• Perform general lab maintenance including ordering supplies and making cell culture media.

• Receive training and perform advanced research techniques including cryo-electron microscopy, computational biology, and protein biochemistry.


Required Qualifications:

• Specialists appointed at the Junior rank must possess a minimum of a Bachelor’s degree in biomedical sciences or related field.

• Specialists appointed at the Assistant or Associate rank must possess a minimum of a Master’s degree in biomedical sciences or related field.

• 1-2 years of biomedical research and/or lab management experience.

• Previous experience in biochemistry lab work .


Desired Qualifications:

• Experience in molecular biology including PCR, cloning, and work with recombinant DNA.

• Experience in biochemistry methods including protein expression and purification and work with baculovirus-insect cell expression systems.

• Experience in structural biology methods such as x-ray crystallography.


Appointees in the Specialist series will be expected to engage in specialized research, professional activities and do not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions, and may participate in University and Public Service.


Please apply online at: https://aprecruit.ucsf.edu/apply/JPF01716.


Link: https://aprecruit.ucsf.edu/apply/JPF01716
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: MS
Conditions: NDG
Job posted: December 8th, 2017
University of CaliforniaSan Francisco, CAMSNDGDec 08, 2017
NEW! Assistant or Associate Professor, Computational & Systems Biology

Assistant or Associate Professor, Computational & Systems Biology

(Click title to open job details in a new window.)
Description:

The Department of Pathology and Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania seeks candidates for an Assistant or Associate Professor position in the tenure track. The successful applicant will have experience in the field of systems biology emphasizing the central nervous system. Responsibilities include developing and carrying out an independent research program that is synergistic with the scientific missions of Penn Neurodegeneration Genomics Center, and participating in graduate and medical school education. Applicants must have an Ph.D. and/or M.D. degree and have demonstrated excellent qualifications in education and research.


The successful candidate should interface with the strong ongoing programs in the genetics and pathobiology of neurodegenerative diseases. We seek candidates who will develop cutting edge research that develops computational models, methodologies and/or experimental approaches to address biological and biomedical problems related to the brain with the eventual goal of developing therapeutic interventions for major neurodegenerative diseases. Potential research focus includes but is not limited to modeling cellular and molecular interactions and pathways, use of model organisms for generating human disease oriented leads, analysis of large genomic and phenotype data sets, and personalized medicine for central nervous system disorders. Experience in systems biology and human genetics is desirable. The Department of Pathology and Laboratory Medicine (http://pathology.med.upenn.edu/), the Penn Neurodegeneration Genomics Center (http://www.med.upenn.edu/pngc/), and the University of Pennsylvania (http://www.upenn.edu/) include faculty with diverse investigative interests with ample opportunities for collaborations.


Applicants should submit a cover letter, curriculum vitae, and a research statement. Review of applications will begin on immediately and will continue until the position is filled.


Apply for this position online at: https://www.med.upenn.edu/apps/faculty_ad/index.php/g/d4878


Link: https://www.med.upenn.edu/apps/faculty_ad/index.php/g/d4878
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: PhD and/or MD
Conditions: NDG
Job posted: December 7th, 2017
Applications close: February 5th, 2018
University of PennsylvaniaPhiladelphia, PAPhD and/or MDNDGDec 07, 2017
NEW! Assistant, Associate or Full Professor, Biomedical Sciences

Assistant, Associate or Full Professor, Biomedical Sciences

(Click title to open job details in a new window.)
Description:

The UTRGV School of Medicine is seeking Faculty members at the Assistant, Associate or Professor level experienced in research in Biomedical Sciences. The background should be in all disciplines of biomedical sciences including endocrine and metabolic diseases (such as diabetes and obesity), neuroscience and neurodegenerative diseases, cancer or oncology research and research in infectious diseases. The selected individuals will carry out high quality research projects and are expected to successfully acquire extramural research support. Laboratory space, competitive salary and start-up packages are available. Postdoctoral research experience in a top-rated research program is preferred.


Candidates must possess a terminal Degree of (Ph.D. or M.D.) or equivalent with post-doctoral experience in the area of expertise. Academic rank will be awarded commensurate with experience and academic credentials.


For consideration, please forward a copy of your CV, statement of interest, future research plan and three references.


Link: https://jobs.sciencecareers.org/job/472848/new-medical-school-seeks-biomedical-science-faculty/
Employer: University of Texas Rio Grande Valley School of Medicine
Location: Edinburg, Texas
Sector: Academia
Degree required: PhD or MD
Conditions: NDG
Job posted: December 5th, 2017
University of Texas Rio Grande Valley School of MedicineEdinburg, TexasPhD or MDNDGDec 05, 2017
Chief of Staff, VA

Chief of Staff, VA

(Click title to open job details in a new window.)
Description:

VA Puget Sound Health Care System (VAPSHCS), located in Seattle, Washington, and the University of Washington (UW) are recruiting for a Physician to serve as their Chief of Staff to provide administrative, programmatic, and clinical leadership for the medical center.


VAPSHCS provides health care annually to more than 100,000 Veterans in a large geographic area between two major divisions, Seattle and American Lake, as well as VA-staffed Community-Based Outpatient Clinics throughout Western Washington. The medical center has a strong affiliation with the University of Washington School of Medicine as well as a number of other educational institutions, and hosts hundreds of medical residents in 37 specialties, dental residents in three specialties, medical students, nursing-auxiliary students, and nursing-professional students. VAPSHCS has one of the most robust and competitive research programs in VA and is home to seven nationally recognized Centers of Excellence: Multiple Sclerosis Center of Excellence West (MSCoE West), Center of Excellence in Substance Abuse Treatment and Education (CESATE), Epilepsy Center of Excellence, Amyotrophic Lateral Sclerosis (ALS) Center of Excellence, Center of Excellence in Primary Care Education, RR&D Center of Excellence for Limb Loss Prevention and Prosthetic Engineering, and Center of Innovation for Veteran-Centered and Value-Driven Care.


The qualified applicant to the Chief of Staff position will be a physician (M.D. or foreign equivalent), who is board certified in any specialty recognized by the American Board of Medical Specialties (or foreign equivalent) and holds significant leadership, mentoring, and management experience in a tertiary care environment, plus strong health care operations and planning experience. S/he must have demonstrated expertise in the academic missions of education and research in an affiliated environment and would be appointed to the full-time faculty at the University of Washington at the Associate (Job Class Code 0112) or Full Professor (Job Class Code 0111) level, without tenure due to funding (WOT). These are 12-month, indefinite appointments. University of Washington faculty engage in teaching, research and service.


Other Requirements: US citizenship; current, full and unrestricted license to practice medicine in a state, territory, or commonwealth of the United States; fluency in spoken and written English.


Link: https://main.hercjobs.org/jobs/10523960/school-of-medicine-va-chief-of-staff-8211-associate-or-full-professor-wot-aa21613
Employer: University of Washington
Location: Seattle, WA
Sector: Academia
Degree required: MD
Conditions: NDG
Job posted: December 1st, 2017
University of WashingtonSeattle, WAMDNDGDec 01, 2017
Clinical Assistant Professor, Neuropsychology

Clinical Assistant Professor, Neuropsychology

(Click title to open job details in a new window.)
Description:

The Neuropsychology Section in the Department of Neurology at the Indiana University School of Medicine and Indiana University Health Physicians has an immediate opening for an Adult Neuropsychologist at the rank of Clinical Assistant Professor. The Section of Neuropsychology is situated in new space inside a unique, integrated clinical neuroscience center of excellence, comprising neurology, psychiatry, neurosurgery, and related services. Responsibilities will include coordination and provision of clinical assessment services, participation in multidisciplinary treatment teams, supervision of pre- and postdoctoral trainees and staff, and participation in the overall academic mission (including lectures to neurology residents). Major patient populations include neurodegenerative diseases, movement disorders, epilepsy, oncology, and brain injury, as well as a broad range of complex medical disorders. Although primarily a clinical position, there are significant opportunities for participation in research, including brain imaging work in alcoholism risk, Alzheimer disease, stroke, epilepsy, etc. Requirements include post-doctoral training in clinical neuropsychology and eligibility for licensure in Indiana. Preference will be given to ABPP-eligible or already board certified clinicians experienced with the above patient populations. Applications will be considered until the position is filled. Indiana University is an EEO/AA Employer, M/F/D. Qualified candidates should submit a letter of career goals and interests and a current CV to: http://indiana.peopleadmin.com/postings/5050


Link: http://indiana.peopleadmin.com/postings/5050
Employer: Indiana University
Location: Indianapolis, IN
Sector: Academia
Degree required: Board-certified neuropsychologist preferred.
Conditions: NDG
Job posted: December 1st, 2017
Indiana UniversityIndianapolis, INBoard-certified neuropsychologist preferred.NDGDec 01, 2017
Postdoctoral Fellow, Shirley Ryan AbilityLab

Postdoctoral Fellow, Shirley Ryan AbilityLab

(Click title to open job details in a new window.)
Description:

The Single Motor Unit Laboratory (SMPP) strives to understand how the nervous system controls individual motor units within a muscle so as to enable the generation of muscle force. Seeks to investigate the role of intrinsic properties of motoneurons that innervate relevant muscle fiber populations in providing such control under normal conditions and following such illnesses as stroke, spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS).


The PostDoc Fellow will be responsible for the design, execution and interpretation of experiments within a laboratory team environment and a larger laboratory research program of engineers, physical therapists and neuroscientists focused on sensory motor performance and rehabilitation within a major, nationally leading Academic Rehabilitation Hospital.


The PostDoc Fellow consistently demonstrates support of the SRAlab statement of Mission and Philosophy by striving for excellence, contributing to the team efforts and showing respect and compassion for patients and their families, fellow employees, and all others with whom there is contact at or in the interest of the institute.


The PostDoc Fellow demonstrates SRAlab Core Attributes: Communication, Accountability, Flexibility/Adaptability, Judgment/Problem Solving, Customer Service and SRAlab Values (Hope, Compassion, Discovery, Collaboration, & Commitment to Excellence) while fulfilling job duties.


Link: https://ricc-hr.silkroad.com/epostings/index.cfm?fuseaction=app.jobinfo&jobid=178712&company_id=16087&version=1&source=ONLINE&jobOwner=994841&aid=1
Employer: Shirley Ryan AbilityLab
Location: Chicago, IL
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: December 1st, 2017
Shirley Ryan AbilityLabChicago, ILPhDALSDec 01, 2017
Postdoctoral Fellow, Zhang Lab

Postdoctoral Fellow, Zhang Lab

(Click title to open job details in a new window.)
Description:

Two fully funded postdoctoral positions are immediately available, in the laboratory of Chun-Li Zhang, Ph.D., Department of Molecular Biology. One is to examine human neurodegenerative disease by using human embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and age-matched directly reprogrammed neurons. The focus is on molecular and cellular mechanisms underlying degeneration and the identification of chemical compounds promoting neuronal survival and function.


The second position is to examine neural reprogramming and regeneration after brain and spinal cord injury and degeneration. The focus is on reprogramming endogenous glial cells to functional neurons in the adult brain and spinal cord. Molecular mechanisms, neural circuitry, and behaviors will be examined.


The Zhang laboratory is well equipped for both in vitro and in vivo studies in modern neuroscience. The successful candidate will also benefit from exceptional core facilities and a very collaborative environment. UT Southwestern is the home of 6 Nobel Laureates, 22 members of the National Academy of Sciences, and 18 members of the National Academy of Medicine.


Self-motivated individuals with a Ph.D. degree and solid publication records are encouraged to apply. Candidates with experience in molecular and cellular neuroscience and electrophysiology are preferred.


Interested individuals should send a CV, statement of interests, and a list of three references to:


Chun-Li Zhang, Ph.D.W. Caruth, Jr. Scholar in Biomedical Research

Department of Molecular Biology, Center for Regenerative Science and Medicine

UT Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390-9148


E-mail: Chun-Li.Zhang@UTSouthwestern.edu


Link: http://neurojobs.sfn.org/jobs/10519749/postdoctoral-fellow-on-neurodegeneration-and-regeneration
Employer: University of Texas-Southwestern
Location: Dallas, TX
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: November 30th, 2017
University of Texas-SouthwesternDallas, TXPhDNDGNov 30, 2017
Postdoctoral Fellow, Sareen Lab

Postdoctoral Fellow, Sareen Lab

(Click title to open job details in a new window.)
Description:

Dr. Dhruv Sareen’s independent research laboratory at the Cedars-Sinai Medical Center, Regenerative Medicine Institute focuses on using human iPSC technology to understand the molecular mechanisms underlying neurodevelopmental/degenerative diseases and how obesity is linked to the brain. His laboratory is particularly interested ‘disease-in-a-dish’ modeling for neuromuscular, neurodegenrative and motor neuron diseases including, amyotrophic lateral sclerosis (ALS). They are particularly interested in C9orF72 and other genetic forms of ALS and what are the common elements with sporadic forms of ALS. Using the iPSC platform his lab has developed novel methods for drug screening on patient motoneurons and dissecting mechanisms for motoneuron degeneration. In the context of stem cell modeling of neurodevelopmental (SMA) and neurodegenerative diseases (ALS) Dr. Sareen’s group is particularly interested in the mechanistic insights how specific neural cell types degenerate during the disease processes. They are using OMICS (proteome, transciptome, metabolome) and imaging methodologies to gain mechanistic insights into the mitochondrial and endorplasmic reticulum stress involvement. In addition, by understanding how the cells of the nervous system develop and differentiate we will be able to develop better and safer cells for transplantation and regenerative therapies. Dr. Sareen’s group has extensive experience in pluripotent and neural stem cell research. He has developed and directed a well-renowned human iPS cell core. He has published high-profile manuscripts on human iPSC-based disease modeling in SMA and ALS.


Dr. Sareen’s laboratory is searching for a highly-capable Post-doctoral Researcher to join his research group to investigate disease mechanisms in neurodegenerative diseases, especially motor neuron disorders. The incumbent should have experience in in neurobiology, biochemistry, molecular biology and stem cells, including analyzing their genetic and biochemical profiles by OMICS technologies. Bioinformatics (programming in R) knowledge is a plus. By using human iPS cell technology and differentiating into different brain cells as well as other tissues of the body we will investigate brain-linked disease mechanisms to develop assays in patient-derived enural cell types and screen for novel therapeutics. Working independently but in close cooperation and in consultation with the PI and other Research Scientists at RMI, the Post-doctoral Researcher will perform routine and complex laboratory procedures throughout. The Post-doctoral Researcher will be expected to assist the PI in preparation of multiple grant proposals and submission of such proposals. They will also prepare full manuscripts for publication as primary first and co-authors. The researcher will be expected to assist the PI in maintaining institutional IRB/SCRO protocols as well as develop new animal and IACUC protocols. The incumbent will develop, adapt, and implement new research techniques and protocols and will analyze and interpret data. They will participate in presentations as author or co-author on scientific meeting abstracts.


Under the direction of Dr. Sareen (PI) the incumbent will help us achieve our research goals by performing the principal duty of using pluripotent and neural stem cell culture techniques to generate neuronal and other tissue differentiation protocols, characterization of the differentiated cells (control vs disease) using techniques such as gene and protein expression, physiological, and phenotypic assessments. The candidate will also be expected to develop and perform differentiation protocols to direct pluripotent stem cells to endoderm, ectoderm and mesoderm lineages. The successful candidate will be responsible for all cell maintenance, expansion and genetic modification using viral vectors or other gene-editing methods. Therefore, experience in stem cell and neurobiology, knowledge of pluripotent/neural cell markers combined with a proven record in stem cell culture techniques is essential. Experience with bioinformatics analysis of RNA-seq and mass spec proteomics data are important.


Prior experience in novel genome-editing technologies (CRISPR/Cas9) using pluripotent stem cells is a great asset. Prior experience in high-content compound screening/imaging techniques, handling of the Molecular Devices Image Express Micro system, and a Mass Spectrometer with data analysis are preferred traits. Proficiency in computer algorithm development for automating image-based analysis is also a desirable trait.


Link: https://www.cedars-sinaimedicalcenter.apply2jobs.com/ProfExt/index.cfm?fuseaction=mExternal.showJob&RID=26507&CurrentPage=26
Employer: Cedars Sinai
Location: Los Angeles, CA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: November 29th, 2017
Cedars SinaiLos Angeles, CAPhDALSNov 29, 2017
Postdoctoral Fellow, Knowles Lab

Postdoctoral Fellow, Knowles Lab

(Click title to open job details in a new window.)
Description:

Applications are invited for a Postdoctoral Research Associate (PDRA) to work on the development and applications of a microfluidic platform for analysing of Fused in Sarcoma (FUS) protein assembly, with a focus on liquid-liquid phase transitions using recombinant protein, cellular and cultured neuron systems, a project funded by the Wellcome Trust. The PDRA will work in the group of Professor Knowles in the Department of Chemistry.


The aim of this interdisciplinary project is to gain mechanistic insights into the aggregation of Fused in Sarcoma (FUS) proteins, known to be associated with two neurological pathologies, Amyotrophic lateral sclerosis (ALS) and Frontotemporal lobar degeneration (FTLD). In ALS, modification in FUS’ methylation prevents it from binding transportin and sequesters it in the cytoplasm, where it accumulates and aggregates to form cytoplasmic inclusion.


To understand the role of protein methylation on the aggregation and phase transition mechanism and the risk of malignant progression it is important to understand the physicochemical basis of this phenomena both in-vitro and using in-vivo cell culture models. To this end the PDRA will combine cell biology with microfluidic techniques to develop biophysical toolkit that allows real-time characterisation of FUS aggregation kinetics and apply these to experiments at single cell resolution.

Candidates should have (or be about to obtain) a PhD in chemistry, biophysics, soft materials science or a related discipline. Prior experience with microfluidics is an advantage but not required. Applicants will be expected to work in an interdisciplinary environment and interact with a team of scientists with a wide range of expertise in biophysics and biophysical chemistry.


To apply online for this vacancy and to view further information about the role, please visit: http://www.jobs.cam.ac.uk/job/15840/


This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the ‘Apply online’ button and register an account with the University’s Web Recruitment System (if you have not already) and log in before completing the online application form.


Please ensure that you upload your Curriculum Vitae (CV), a covering letter and publications list in the upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.


For queries relating to your application or the application process, please contact Echo Williamson (email: jw825@cam.ac.uk).


Please quote reference MA14082 on your application and in any correspondence about this vacancy.


Link: http://www.jobs.cam.ac.uk/job/15840/
Employer: University of Cambridge
Location: Cambridge, England
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: November 24th, 2017
University of CambridgeCambridge, EnglandPhDALS, FTDNov 24, 2017
Assistant Professor, Biological Sciences

Assistant Professor, Biological Sciences

(Click title to open job details in a new window.)
Description:

The Department of Biological Sciences in the School of Natural Sciences and Mathematics at the University of Texas at Dallas (http://www.utdallas.edu/biology/) invites applications for a faculty position at the rank of Assistant Professor. We seek to hire an outstanding scientist with research interests that complement and build on existing departmental strengths in biochemistry, cell and molecular biology, computational and systems biology, genomics, microbiology, and pathobiology (cancer, neurodegenerative disorders, and infectious disease). Since the department has the goal of expanding its research and teaching into new directions, we will also consider applications from excellent candidates in other areas of the biological sciences. Review of applications will begin immediately and will continue until the position is filled.


Link: https://jobs.utdallas.edu/postings/9167
Employer: University of Texas
Location: Dallas, Texas
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: November 22nd, 2017
University of TexasDallas, TexasPhDNDGNov 22, 2017
Research Associate, Grinberg Lab

Research Associate, Grinberg Lab

(Click title to open job details in a new window.)
Description:

The Staff Research Associate II (SRA II) position is for a full time lab technician (Research Assistant) to assist the Principal Investigator (PI) in neuropathology research that investigates the pathogenesis of Alzheimer’s disease, frontotemporal dementia, and related disorders at UCSF Mission bay campus (see http://grinberglab.ucsf.edu).


The candidate is expected to be open to learning new methods.


The position represents an excellent opportunity to further basic laboratory and research skills in a dynamic clinical neuroscience environment. The successful applicant will be an energetic, team player, self-directed learner with a keen interest in research.


The candidate will need excellent dexterity for sectioning tissue using a microtome.


Link: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?partnerid=6495&siteid=5226&jobId=2612662
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: BA or BS
Conditions: FTD
Job posted: November 22nd, 2017
University of CaliforniaSan Francisco, CABA or BSFTDNov 22, 2017
Research Associate, Lakatos Lab

Research Associate, Lakatos Lab

(Click title to open job details in a new window.)
Description:

An MRC funded postdoctoral position is available in the laboratory of Dr Andras Lakatos at the University of Cambridge. The research group focuses on regulators of transcriptional networks and novel signalling pathways in astrocyte-neuron-synapse interactions. In specific, this exciting project is aimed at elucidating mechanisms underlying novel cell-communication pathways under physiological conditions, injury and in neurodegenerative diseases, such as Motor Neuron Disease (MND)/Amyotrophic Lateral Sclerosis (ALS).


The successful applicant will use cutting-edge technologies, including in vivo/ex vivo transgenic mouse and/or translational human disease models in combination with computational approaches to reveal astrocyte-mediated mechanisms driving degeneration or recovery of the neuronal network.


The candidate must have a PhD (or equivalent) in neurosciences or biological sciences with first author publication(s) and a strong background in mammalian cell culture techniques, cell and molecular biology. Experience in at least one of the following areas is desired: human stem cell biology, CRISPR/Cas9 genome editing, calcium imaging, analysis of RNA-sequencing and proteomic data, computational modelling and network analysis. We seek a candidate with strong organisational skills and aptitude for semi-independent and team work.


The post is a unique opportunity for a scientist in regenerative neurobiology, who will join a dynamic group of basic and clinician scientists and will interact with collaborating groups in the UK and USA to pursue fundamental and clinically relevant questions in neurosciences.


If you have any questions about this vacancy or the application process, please contact Dr Andras Lakatos by email at the first instance (AL291@cam.ac.uk). For further information about the laboratory please visit: http://www.neuroscience.cam.ac.uk/directory/profile.php?lakand


To apply online for this vacancy and to view further information about the role, please visit:

http://www.jobs.cam.ac.uk/job/15785/


Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.


Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.


Closing date for applications is the 17th December 2017.


Link: http://www.jobs.cam.ac.uk/job/15785/
Employer: University of Cambridge
Location: Cambridge, England
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: November 20th, 2017
Applications close: December 17th, 2017
University of CambridgeCambridge, EnglandPhDALSNov 20, 2017
Chair, Neurological Sciences

Chair, Neurological Sciences

(Click title to open job details in a new window.)
Description:

The College of Medicine at Florida State University has embarked on a strategic effort to increase basic and translational research in human neuroscience. In an effort to extend our impact in neural health, we are seeking applications for the College of Medicine’s Mina Jo Powell Chair in Neurological Sciences.


Qualifications:

A senior basic- or clinician-scientist (PhD or MD) at the Associate or Full Professor level with a proven track record of excellence in creative approaches to neuroscience, generating peer-reviewed funding, and leading interdisciplinary groups. Must possess the leadership capabilities for directing their own research cluster.


Responsibilities:

The Mina Jo Powell Chair is open to an outstanding individual who specializes in using functional magnetic resonance imaging as a core component of their research program, and will have full access to a new research-dedicated 3T Siemens MAGNETOM Prisma in the MRI facility housed at the College of Medicine.


The Mina Jo Powell Chair is expected to build upon existing strengths in neuroimaging, neurobiology of sex differences in anxiety and depression, traumatic brain injury, spinal cord injury, sex differences in development and behavior, synaptic physiology underlying cortical function and epilepsy, psychopharmacology and developmental basis of mental health disorders, plasticity of neuronal circuits and their pathology in neurodevelopmental disorders, neurodegeneration and neuropharmacology of CNS dopamine systems related to neuromuscular disorders.


How to Apply:


To apply, please go to: www.jobs.fsu.edu and search by job ID 42346. In addition to an online application, please upload with the application as well as send the following in a single PDF file: a detailed curriculum vitae page overview of current and future research plans, and a list of at least three professional references to:

Dr. Jeffrey N Joyce, Chair of the Search Committee, Jeffrey.Joyce@med.fsu.edu

Natasha Coen, Sr. Administrative Specialist, Natasha.Coen@med.fsu.edu.


Link: https://jobs.sciencecareers.org/job/470884/associate-professor-professor-and-endowed-chair/?TrackID=178258&utm_source=Widget&utm_medium=neurodegeneration&utm_campaign=ALS#sc=widget&me=referral&cm=178258
Employer: Florida State University College of Medicine
Location: Tallahassee, Florida
Sector: Academia
Degree required: PhD or MD
Conditions: NDG
Job posted: November 16th, 2017
Florida State University College of MedicineTallahassee, FloridaPhD or MDNDGNov 16, 2017
Postdoctoral Fellow, FTD and Neurodegenerative Dementias

Postdoctoral Fellow, FTD and Neurodegenerative Dementias

(Click title to open job details in a new window.)
Description:

The project aims to elucidate the pathogenicity of identified genetic variants primarily in frontotemporal dementia (FTD) by setting up functional assays. Validation of results will be performed on patient derived tissue such as fibroblasts, iPSC, cerebrospinal fluid, serum and plasma as well as post mortem brain tissue. This position will be held in the research group called “Translational genetics of neurodegenerative diseases” which sits at the interface of clinical and experimental research and is led by Proffessor C Graff. Currently the group has about 10 members including professor, postdoc, PhD students and technicians. The research focus is on the genetics of FTD and AD. The group is also responsible for the Brain Bank at KI and the Genetics Unit at the Karolinska university Hospital. The laboratory will be located at Bioclinicum, in Solna, as of January 2018. Prof Graff is now looking to expand this group with another co-worker for a 2-year postdoc position.


The successful candidate will lead molecular genetic projects aimed at elucidating the pathogenicity of human genetic variants in FTD and other related neurodegenerative diseases. At your disposal will be genomic DNA, RNA, fibroblasts, iPSC, serum, plasma, csf and brain tissue from patients with potentially pathogenic mutations identified through whole genome/exome sequencing and or mutation screening. The position will include responsibility to set up functional assays in collaboration with several core facilities at Karolinska Institutet and other team members with expertise in human molecular genetics, geriatrics, and cell culture.


Further responsibilities will include, but are not limited to, contribution to the interpretation of whole genome sequencing results from patients with FTD and related diseases to identify likely pathogenic variants. You will also support technicians and students in their work to succeed and successfully deliver data for interpretation and publication.


A person is eligible for this position as Postdoctoral Researcher if he or she has obtained a PhD in molecular genetics, molecular biology, cell biology, biotechnology, biomedicine, or similar topic no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances.


The successful candidate has a strong background in human molecular biology or human genetics. Documented knowledge of the molecular biology and genetics of FTD/ALS, documented experience of functional studies of neurodegenerative diseases, skills in basic molecular biological techniques such as DNA/RNA/protein extraction, WB, cloning, and sequencing is required. The candidate needs to be independent, innovative, and able to actively lead complex translational projects. You should have excellent written and oral English communication skills.


It is also preferred if the candidate has knowledge in gene editing/cloning, cell culture, animal models of FTD, bioinformatics of –omics, massive parallel sequencing technologies, single cell/single molecule analysis, laser capture microdissection, assays of autophagy and neurodegeneration in mammalian cells, neuropathology, immunohistochemistry and previous experience in leading projects into published scientific articles. Previous experience in elucidating the pathogenicity of human genetic variants in frontotemporal dementia (FTD) using functional assays is a strong merit. Substantial consideration will be given to personal suitability during the selection process.


An employment application must contain the following documents in English or Swedish:

*A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work

*A complete list of publications

*A summary of current work (no more than one page)

*Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances


Link: https://ki.mynetworkglobal.com/se/what:job/jobID:177178/type:job/where:4/apply:1
Employer: Karolinska Institutet
Location: Huddinge, Sweden
Sector: Academia
Degree required: PhD
Conditions: FTD
Job posted: November 15th, 2017
Applications close: December 5th, 2017
Karolinska InstitutetHuddinge, SwedenPhDFTDNov 15, 2017
Associate or Full Professor, Neuroscience

Associate or Full Professor, Neuroscience

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Description:

The Department of Neuroscience and Center for Brain Immunology and Glia at the University of Virginia are seeking candidates for tenure-eligible Associate and Full Professor positions.


Candidates must have a PhD, MD, or MD/PhD, and at least 10 years of neuroscience and/or immunology research experience, as well as a history of exceptional publications and extramural funding. Incumbents will be expected to run an extramurally funded research laboratory in which post docs, graduate, and undergraduate students will play major roles. The candidate will also be expected to participate in the educational and service missions of the School of Medicine.


As a member of the Center and of the Department of Neuroscience the candidate is expected to interact with other faculty members in developing program project proposals in the area of neuroimmunology/glia biology, participate in Center and Departmental activities, and lead efforts in mentoring trainees and junior faculty members. Areas of focus include, but are not restricted to: neuroimmunology; microglia biology in neurodegenerative disorders; astroglia physiology; and blood-brain barrier function in healthy and diseased brain. A particular interest of the Center is in neurodegenerative disorders such as Alzheimer’s disease, neurodevelopmental, and mental/cognitive disorders. More information on the Department of Neuroscience is available at: http://www.medicine.virginia.edu/basic-science/departments/neuroscience.


For additional information about the position (no application materials please), contact the search committee chair, Dr. Scott Zeitlin, 434-924-5011, soz4n@Virginia.EDU.


To apply, visit https://jobs.virginia.edu and search on Posting Number 0617671. Complete a Candidate Profile online, attach a cover letter, curriculum vitae, and contact information for three references.


Positions will remain open to applications until filled.


Link: https://main.hercjobs.org/jobs/10473216/associate-professor-full-professor
Employer: University of Virginia
Location: Charlottesville, VA
Sector: Academia
Degree required: PhD, MD, or MD/PhD
Conditions: NDG
Job posted: November 12th, 2017
University of VirginiaCharlottesville, VAPhD, MD, or MD/PhDNDGNov 12, 2017
Postdoctoral Fellow, Taylor Lab

Postdoctoral Fellow, Taylor Lab

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Description:

A postdoctoral position to study the molecular and cellular mechanisms of neurodegenerative disease, including amyotrophic lateral sclerosis and frontotemporal dementia, is available at the St. Jude Children’s Research Hospital in Memphis, TN, USA. We identified that many of neurodegenerative diseases are caused by defects in the assembly, disassembly, or clearance of cellular packages of RNA and proteins known as RNA granules. Our research focus is to investigate the role of RNA granules in regulating gene activity, explore how granules are assembled and disassembled, and investigate how these types of defects in RNA metabolism can cause neurodegenerative diseases.


Toward this end we:

*Use in vitro and in vivo modeling to elucidate the molecular basis of neuronal dysfunction and neuronal loss in neurological diseases

*Use the fruit fly Drosophila melanogaster to apply the power of genetics to illuminate the pathogenesis of neurodegeneration

*Investigate the molecular genetics of amyotrophic lateral sclerosis, frontotemporal dementia, inclusion body myopathy and polyglutamine disease

*Screen small molecules to identify compounds that can be translated to clinical use


Link: https://postdoc-stjude.icims.com/jobs/3041/postdoctoral-research-assoc/job?mode=job&iis=Job%2BPosting&iisn=LinkedIn&mobile=false&width=1180&height=500&bga=true&needsRedirect=false&jan1offset=-300&jun1offset=-240
Employer: St Jude Children's Research Hospital
Location: Memphis, TN
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: November 10th, 2017
St Jude Children's Research HospitalMemphis, TNPhDALS, FTDNov 10, 2017
Chair, Center for Regenerative Therapies

Chair, Center for Regenerative Therapies

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Description:

At the Center for Molecular and Cellular Bioengineering (CMCB), Center for Regenerative Therapies Dresden (CRTD) the position of Chair (W3) of Models of Regeneration is to be filled as soon as possible. The CRTD (www.crtdresden.de) consists of 19 research and junior research groups working in the areas of Haematology/lmmunology, Diabetes, Neurodegenerative diseases as well as Bone regeneration.


The holder of the chair should have an outstanding international reputation in tissue regeneration and stem cell research, and should conduct modern molecular and cellular research using vertebrate model organisms. The candidate is expected to represent the full spectrum of the research area in academic teaching. A willingness and ability to conduct classes in German and English is expected. The duties include participation in academic selfadministration.


Applicants must fulfill the employment qualification requirements of § 58 of the Act Governing Academic Freedom in Higher Education in the Free State of Saxony (Saxon Academic Freedom in Higher Education Act – SächsHSFG). Prerequisites include a university degree in natural sciences or medicine, a doctoral degree and a habilitation or equivalent qualification record. The position further requires previous teaching experience, an outstanding international track record in scientific research and publications, and in acquired third-party funding.


The position is provided with excellent financial resources for research. The Technische Universität Dresden provides a rich environment for scientific collaboration including the Biotechnology Centre and the Centre of Innovation Competence B CUBE, the Faculty of Medicine Carl Gustav Carus and the School of Science. The Dresden International Graduate School of Biomedicine and Bioengineering“ as well as non-university research institutes such as the Max Planck Institute of Molecular Cell Biology and Genetics, Paul-Langerhans- lnstitute Dresden, German Center for Neurodegenerative Diseases and the Leibniz Institute of Polymer Research Dresden offer additional opportunities for collaboration in the highly interactive research environment in Dresden.


TU Dresden seeks to employ more female professors. Hence, we particularly encourage women to apply. Applications from disabled candidates or those with additional support needs are very welcome. The University is a certified family-friendly university and offers a dual career service. lf you have any questions about these topics, please contact the Equal Opportunities Officer of CMCB (Mr Martin Kaßner, phone +49 351 458-82082) or the Repre- sentative of Employees with Disabilities (Ms Birgit Kliemann, phone +49 351 463-33175).


Applications including a CV, a complete publication list and a short list of the ten most important publications, a list of funds received from thirdparty donors, a description of teaching experience, results of evaluations of the last three years and a future research plan (max. 5 pages) as well as a certified copy of the highest academic degree should be sent until 18.12.2017 (stamped arrival date applies) as hard copy to TU Dresden, CRTD, Herrn Prof. Dr. Michael Brand, Fetscherstraße 105, 01307 Dresden, Germany and as electronic copy via the TU Dresden SecureMail Portal https://securemail.tu-dresden.de to michael.brand@tu-dresden.de.


Link: https://jobs.sciencecareers.org/job/470008/chair-w3-of-models-of-regeneration/
Employer: Technische Universität Dresden
Location: Dresden, Germany
Sector: Academia
Degree required: NDG
Conditions:
Job posted: November 9th, 2017
Applications close: December 18th, 2017
Technische Universität DresdenDresden, GermanyNDGNov 09, 2017
Graduate Studentship, Ning and Ramesh Labs

Graduate Studentship, Ning and Ramesh Labs

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Description:

The cause of motor neuron (MN) degeneration is unknown in the majority of cases of ALS, although a number of pathogenic processes, including protein aggregation, mitochondrial dysfunction, oxidative stress, excitotoxicity and neurofilament dysfunction, are thought to play important roles in ALS. It has been reported that the capacity of the proteasome system to degrade proteins may be a limiting factor in the vulnerability of neurons to the degenerative process. Arfaptin-2, a downstream effector of ADP-ribosylation factors (ARFs), was identified as a novel protein as a target protein for GTP-ARFs and for GDP- Rac1. Humbert and colleagues showed that phosphorylation of Arfaptin-2 at Ser260 by Akt inhibits polyQ-huntingtin- induced toxicity by rescuing proteasome impairment (Rangone H et al, J Biol Chem 2005).

Our previous studies showed that Arfaptin 2 regulates the aggregation of mutant huntingtin protein and that a dominant inhibitory mutant of arfaptin 2 (HC-AIP2) inhibits aggregation of mutant huntingtin by activating and rescuing proteasome function (Peters PJ and Ning K et al, Nat Cell Biol, 2002). Our recent data also showed that overexpression of HC-AIP2 significantly increases cell survival in primary cultured SOD1 G93A motor neurons. Therefore, we hypothesize that arfaptin-2 plays a modulatory role in ALS and expression of a dominant inhibitory mutant of arfaptin-2 (HC-AIP2) would improve motor neuron survival via activation of proteasome activities in the sod1 and C9orf72 zebrafish model of ALS.


The Specific Aims Are


*To investigate expression and distribution of arfaptin-2 in control and ALS Brains;

*To assess whether depletion of arfaptin 2 affects disease pathogenesis in the sod1 and C9orf72 zebrafish model of ALS;

*To study the effects of HC-AIP2 on motor neuron survival and lifespan in models of ALS.


The outcome of the above specific aims would gain valuble evidence that arfaptin 2 is a therapeutic target for ALS. The next logical step is to devolop preclincal and clinical treatment of gene therapy for ALS patients.


This is a high profile project to investigate arfaptin 2 as a neuro-protective target for ALS. Apart from molecular and cell biology, the student will receive training on how to handle zebrafish and assess behavioural analysis, histological analysis of pathology. The work described here will be achieved in the state-of- the-art Translational Neuroscience Laboratory under the supervision of Dr. Ke Ning (primary supervisor, http://sitran.org/people/ning/ ) and Dr Tennore Ramesh (secondary supervisor, http://sitran.org/people/ramesh/ ).


Link: https://www.globalacademyjobs.com/jobdetails.aspx?id=68381&utm_source=attb
Employer: University of Sheffield
Location: Sheffield, England
Sector: Academia
Degree required: BS
Conditions: ALS
Job posted: November 9th, 2017
Applications close: January 24th, 2018
University of SheffieldSheffield, EnglandBSALSNov 09, 2017
Senior Research Project Manager

Senior Research Project Manager

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Description:

The IGM is seeking a Senior Research Project Manager interested in joining a group of Investigators using cutting edge genomic technology to study genetics with a primary focus on identifying and biologically characterizing genetic variation underlying human disease.


Responsibilities:

-Direct strategic and financial management activities within the scientific program areas, in particular

providing oversight and direction for studies of epilepsy, amyotrophic lateral sclerosis (ALS), reproductive genomics, schizophrenia, pediatric clinical sequencing, and other IGM precision medicine project areas;

-Advance the strategic planning and implementation of multiple research initiatives. Identify new

funding opportunities. Convene research strategy meetings; identify meeting participants, coordinate

meeting planning & oversee preparation of agendas/other meeting materials;

-Collaborate with the Pre-Award Core to coordinate development of complex proposals that may include

multiple PIs, depts., sites, labs, etc.

-Contribute scientific and research specific content to proposal narratives. Compile and edit proposal

narratives, incorporating original content and material supplied by others. Review and proof proposals;

-Manage the scientific progress of research grants held the Director and collaborative grants the Director is involved with. Develop time lines I milestones and work with collaborating sites to ensure timely submission of all required reports to Federal, collaborating sites and Foundation sponsors;

-Provide guidance on the development of project budget proposals in the Institute. Advise on budget/funding strategy;

-Work closely with IGM financial management staff on budget planning for grant submissions related to the Director or to large collaborative grants within the Institute;

-Ensure that funded projects for the Director of the IGM move forward. With DA and finance, ensure that funds are being spent correctly and effectively.

-Lead coordination of research activities at Columbia with the research activities at other collaborating universities and institutions within the consortiums or working group;

-Oversee efforts to prepare periodic and final reports to sponsors. Work collaboratively with finance to prepare financial portions of reports;

-Collaborate with the finance team and project leaders to coordinate the preliminary data and progress information for the completion of non-competing and competing reports and renewals for Director’s grants. Monitor subcontract expenditures related to the Director’s research to ensure appropriate use of funds are consistent with predefined milestones and scientific progress;

-With DA, ensure that intellectual property and other compliance-related concerns are addressed;

-Oversee implementation of agreements within IGM and act as ongoing point of administrative contact.

Project Management & Coordination

-With the IGM leadership, act as a key representative of the IGM within the research community, and serve as an administrative point person to faculty colleagues and researchers at other institutions. Help lead and support the IGM’s participation in collaborative initiatives, conferences, and colloquia. Organize research-related events hosted by IGM;

-Manage meetings of working groups and project leadership teams (such as Epi4K, Epi25 and e2 working groups, and epi SC monthly teleconferences);

-With the DA and Engagement Officer, provide administrative leadership for IGM’s communications activities, both internal and external. Working with School and institutional communications personnel, develop and implement Institute’s communications plan. This includes joint oversight of the website, mailing lists, and other digital and print communications channels;

-Other duties as required and assigned by the Director and/or DA.


Link: https://main.hercjobs.org/jobs/10463938/senior-research-project-manager
Employer: Columbia University
Location: New York, NY
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: November 9th, 2017
Columbia UniversityNew York, NYBA or BSALSNov 09, 2017
Senior Technician, Project ALS Preclinical Core Facility

Senior Technician, Project ALS Preclinical Core Facility

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Description:

An exciting opportunity for a motivated Senior Technician to join our new Project ALS Preclinical Core Facility at Columbia University Medical Center. The facility tests new treatment strategies and research drugs in mouse models of amyotrophic lateral sclerosis.


Duties will include behavioral monitoring of mice, IP/IV/SC injections, tissue dissection and immunohistochemistry. The incumbent will also be responsible for confocal microscopy, image analysis, statistical evaluation of results, as well as preparing solutions and performing other laboratory related duties necessary to the functioning of the core facility and research projects.


Link: https://main.hercjobs.org/jobs/10463931/senior-technician
Employer: Columbia University
Location: New York, NY
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: November 9th, 2017
Columbia UniversityNew York, NYBA or BSALSNov 09, 2017
Postdoctoral Fellow, Xia Lab

Postdoctoral Fellow, Xia Lab

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Description:

A research lab at the University of Central Florida Medical College invites you to apply for post-doctoral associate position. Research in the lab is focused on the genetic and molecular mechanisms of neurodegeneration in amyotrophic lateral sclerosis and Parkinson’s disease. Our team has published our findings in Acta Neuropath, EMBO J, the Journal of Clinical Investigation, PLoS Genetics, and PNAS. Post-doctors being recruited will help validate the pathogenic role of genetic mutations newly discovered in the lab using cell culture and animal models. The research lab is located at the UCF Burnett School of Biomedical Sciences at the Lake Nona campus. Researchers who have recently obtained their PhD degrees and seek to further develop their academic career are encouraged to apply for the positions. Please email your CV to Dr. Xugang Xia at xugang.xia@ucf.edu


Link: http://neurojobs.sfn.org/jobs/10457770/post-doctoral-associate
Employer: University of Central Florida
Location: Orlando, FL
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: November 8th, 2017
University of Central FloridaOrlando, FLPhDALSNov 08, 2017
Postdoctoral Fellow

Postdoctoral Fellow

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Description:

A postdoctoral position in “Molecular processes relevant for Amyotrophic Lateral Sclerosis (ALS) initiation and progression” will be available in the Center for Life Nanoscience at Istituto Italiano di Tecnologia (CLNS@SAPIENZA, Rome, Italy).


The Project Will Explore:

*The molecular circuitries controlling normal and pathological neuronal differentiation and activity.

*The molecular basis of neuromuscular diseases with specific interest in ALS pathogenesis.

*The pathogenic mechanisms of ALS-associated proteins involved in RNA metabolism.

*The role of long non coding RNAs (lncRNAs) and circular RNAs (circRNAs) in MN differentiation and in neuromuscular diseases with specific interest in the ALS pathology.

*The use of in vitro motor neuron differentiation from mouse Embryonic Stem Cells (mESC) and from human induced Pluripotent Stem Cells (iPS, from controls and ALS patients).

*The use of in vivo animal model systems for studying the activity of non coding RNAs with a relevant role in MN differentiation and function.

Candidates should have a PhD in Molecular Biology or Cell Biology or Biochemistry.


The position requires experience in some of the indicated subjects:

*Knowledge on basic mechanisms of gene expression control.

*Techniques of advanced molecular, biochemical, cellular and imaging methodologies for the study of cell differentiation.

*Characterization and function of non coding RNAs.

*Expertise on cell cultures and on manipulation of mESCs and human iPS.

*Computational skills for RNAseq data analysis


We value candidates with a proactive attitude and results-oriented mind-set, good interpersonal and communication skills and ability to work effectively within an interdisciplinary research team. An internationally competitive salary, dependent on experience, will be offered.

Interested applicants should submite their CV, list of publications, a statement of research interests, and names of two referees to katia.broccoletti@iit.it


Please quote “Molecular processes relevant for Amyotrophic Lateral Sclerosis (ALS) initiation and progression – BC 72946” as your application reference.


Please apply before: November 30, 2017.


Link: https://www.linkedin.com/jobs/view/500709463/
Employer: Istituto Italiano di Tecnologia
Location: Rome, Italy
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: November 4th, 2017
Applications close: November 30th, 2017
Istituto Italiano di TecnologiaRome, ItalyPhDALSNov 04, 2017
Research Associate

Research Associate

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Description:

The School of Health Sciences is seeking to appoint a Research Associate to work on an exciting collaborative MND Scotland and MND Association funded post. The aim of the project is to conduct repeated assessments of people living with Motor Neurone Disease (MND) over the course of the disease, to identify the impact and change of various factors (such as apathy, cognitive functioning and behaviour) in relation to everyday life and wellbeing of people living with MND and their families.


Part-time post (80%fte), available immediately on a fixed-term basis until 30th September 2019. The salary is £25,728 to £31,604 per annum (pro-rata)


You will work within a research team who will collectively undertake psychological, neuropsychological and functional assessments as well as semi structured interviews with patients and their families.


Applicants must hold a good degree in Psychology or a related field, and have good quantitative, administrative and organisational skills, and a flexible and conscientious approach. Sensitivity and professionalism in interacting with people with Motor Neurone Disease and their families is essential.


This post will be subject to a criminal record check from the Disclosure and Barring Service.


Closing date: 12 noon on 4th December 2017.


Further particulars and an application form are available on our website: www.uea.ac.uk/hr/vacancies or Tel. 01603 593493


Link: http://www.jobs.ac.uk/job/BFL179/research-associate-motor-neurone-disease/
Employer: University of East Anglia
Location: Norwich, England
Sector: Academia
Degree required: BS, Psychology
Conditions: ALS
Job posted: November 3rd, 2017
Applications close: December 4th, 2017
University of East AngliaNorwich, EnglandBS, PsychologyALSNov 03, 2017
Postdoctoral Fellow, Disney Lab

Postdoctoral Fellow, Disney Lab

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Description:

Multiple postdoctoral positions in RNA chemical biology are available in the Disney group in the Department of Chemistry at The Scripps Research Institute. Interested applicants should send their CV and three letters of reference to disney@scripps.edu. A full description of the group’s research focus is available on the web at http://www.scripps.edu/disney/.


Projects with an emphasis on structural biology include: (i) developing methods to allow for the structural elucidation of RNA-small molecule complexes by using either NMR spectroscopy and computation or X-ray crystallography; (ii) using these structural studies to understand complex formation in a rigorous biophysical manner and lead optimizing compounds; and, (iii) developing methods to study RNA structure in cells by using cell-permeable chemical reagents.


Projects with an emphasis on chemical biology include: (i) developing methods to rapidly expand information on the small molecules that bind RNA and on the RNA motifs that bind small molecules; (ii) using these data to identify new drug targets from only RNA sequence; (iii) using the identified compounds to study RNA biology in cells and in vivo; and (iv) expanding tools available to manipulate RNA in cells.


Representative publications in this area from our group include: studying the RNA repeats that cause genetically defined ALS and dementia (see: Neuron. 2014 Sep 3;83(5):1043-50) and muscular dystrophy (see: Nat. Chem. Biol. 2017 Feb;13(2):188-193); and using sequence-based RNA drug design to develop novel compounds that target non-coding RNAs in highly drug resistant cancers (see: Nat. Chem. Biol. 2014 Apr;10(4):291-7. and Proc. Natl. Acad. Sci. U.S.A. 2016 May 24;113(21):5898-903).


Successful candidates will have a proven track record of publishing in high impact journals, have experience in nucleic acids, medicinal chemistry, or chemical biology, and can work successfully as a member of a team. An emphasis will be placed on candidates that have a track record of high impact publications. Expertise with RNA-seq data analysis and chemical and structural biology is highly desired.


Link: https://www.nature.com/naturejobs/science/jobs/628519-postdoctoral-associate
Employer: Scripps Research Institute
Location: Jupiter, FL
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: November 2nd, 2017
Applications close: January 1st, 2018
Scripps Research InstituteJupiter, FLPhDALSNov 02, 2017
Staff Associate, Pellizzoni Lab

Staff Associate, Pellizzoni Lab

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Description:

Columbia University’s Department of Pathology and Cell Biology has an immediate opening for a Staff Associate/Sr. Staff Associate position in Dr. Livio Pellizzoni’s lab.The incumbent will be responsible for carrying out fully planned experiments, in liaison with Postdoctoral Research Scientists/Fellows as well as PhD students, to study the molecular and cellular mechanisms of neurodegenerative disease in mouse models. The incumbent will use conventional biochemical, cellular, molecular, immuonohistochemical and behavioral assays. He/She will also maintain the mouse colonies, daily behavioral monitoring of mice, genotyping, ICV/IP injections, tissue dissection and immunohistochemistry. The incumbent will also be responsible for confocal microscopy, image analysis, statistical evaluation of results, as well as preparing solutions and performing other laboratory related duties necessary to the functioning of the research projects.


Link: https://main.hercjobs.org/jobs/10434039/staff-associate-senior-staff-associate
Employer: Columbia University
Location: New York, NY
Sector: Academia
Degree required: BA or BS
Conditions: ALS, SMA
Job posted: November 1st, 2017
Columbia UniversityNew York, NYBA or BSALS, SMANov 01, 2017
Postdoctoral Fellow, Verfaillie Lab

Postdoctoral Fellow, Verfaillie Lab

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Description:

The lab of Dr. Verfaillie at the Stem Cell Institute Leuven is looking for a postdoctoral fellow with expertise in: The lab of Dr. Verfaillie at the Stem Cell Institute at KU Leuven is recruiting an outstanding postdoctoral fellow highly versed in pluripotent stem cell biology techniques, including multicellular organoid cultures either in 2.5D and in 3D in suspension or in hydrogel based static or bioreactor cultures. The goal is to create lifelike small brain tissues, including the blood brain barrier or the cortex, that can be used as disease models in a dish, to study, Alzheimer’s, Parkinson, frontotemporal dementia or ALS available from teams at KU Leuven and the Flemish Institute of Technology (VIB), using patient iPSC and their isogenic counterparts. The technology should enable gaining superior insights in mature brain features such as defined connectivity and neuron-glia interactions, neurodegeneration phenotypes, and identification of druggable phenotypes.


The successful candidate will work in close collaboration with students/postdocs in the team highly experienced in creating different neuronal, glial and endothelial cells from iPSC, as well as with CRISPR/Cas technology and CRISPR/Cas genome screening approaches. In addition, investigators from IMEC will be supporting this effort by providing sensors for continuous monitoring of differentiating cells in 2D, as well as innovative artificial substrates and microfluidics devices for reproducible co-culture of different cell types and organoids.


Link: https://jobs.sciencecareers.org/job/469144/3d-coculture-organoid-cultures-of-brain-structures-from-neurodegenerative-disease-patient-ipscs/
Employer: KU Leuven
Location: Leuven, Belgium
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: October 31st, 2017
KU LeuvenLeuven, BelgiumPhDALS, FTDOct 31, 2017
Junior Group Leader

Junior Group Leader

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Description:

The Center for Psychiatry and Neurosciences of Paris-Descartes University and INSERM (https://cpn.paris5.inserm.fr/research/teams-and-projects) recently started its activities in a 4300 m² brand new building located in central Paris, ion the campus of Sainte-Anne Hospital. Ultimately, this new research center will host a total of 16 junior and senior teams devoted to integrated basic and clinical research. In addition to basic technical resources (cell culture, biochemistry and molecular biology equipment, etc…), research teams have access to technical core facilities for microscopy (confocal, spinning, SIM, STORM, STED), an animal house (10000 rodents capacity), electrophysiology and functional ultra sound imaging, and behavioural phenotyping. These resources are dedicated to interdisciplinary basic and clinical research in psychiatry and neurosciences. We are looking for junior principal investigators who are broadly interested in interdisciplinary neurosciences, including genetics and epigenetics, neurodevelopment, psychiatry, neuropsychopharmacology, computational neurosciences, brain tumours, aging and neurodegenerative diseases, brain imaging and neurovascular exploration, using approaches ranging from molecular and cellular biology to cognitive and translational neurosciences, including mathematics, image analysis and physics applied to neurosciences.


Appropriate office and laboratory spaces for up to 6 persons and a start-up package will be available. Successful candidates should hold a PhD and/or MD degree, have strong postdoctoral experience and meet criteria for to obtaining national (such as Atip-Avenir, ANR-JC, FRM Amorçage or other equivalent grants) and/or international funding (ERC StG), and for French institutional research positions (INSERM, CNRS). These positions are intended for first-time group leaders.


Applications (in English) should be sent to neuropsy2017@inserm.fr, and should include in one single pdf ‘applicantName_neuropsy2017.pdf’:


– a 1 page personal statement explaining why you are interested in joining our new Interdisciplinary Institute,


– a 4 page research plan for the next 5 years,


– a full CV (academic track, publications, patents, awards and fellowships, invited conferences, and teaching/training experience),


– contact details of 3/5 individuals who can be contacted for recommendation letters,


Deadline for applications is December 1st 2017. Short-listed candidates will be invited for interviews, to present their past achievements and research proposal in front of the international scientific advisory board (iSAB) and to visit our structure by the end of April 2018. Please address any question regarding the call to Dr Thierry Galli, CPN’s director: thierry.galli@inserm.fr.


Link: https://jobs.sciencecareers.org/job/469070/call-for-junior-group-leader/
Employer: Paris-Descartes University
Location: Paris, France
Sector: Academia
Degree required: PhD and/or MD
Conditions: NDG
Job posted: October 30th, 2017
Applications close: December 1st, 2017
Paris-Descartes UniversityParis, FrancePhD and/or MDNDGOct 30, 2017
Assistant or Associate Professor, Neuropathology

Assistant or Associate Professor, Neuropathology

(Click title to open job details in a new window.)
Description:

The Division of Neuropathology in Department of Pathology at Brigham and Women’s Hospital, a teaching affiliate of Harvard Medical School, is seeking an academically oriented, Board-certified Neuropathologist, at the Instructor, Assistant or Associate Professor level, with skills in surgical and autopsy neuropathology. Academic rank and salary will be commensurate with experience and accomplishments. Applicants should be committed to excellent patient care, as well as research, scholarship, and effective teaching. Experience or ability to participate in precision medicine and molecular pathology is preferred. Pathologists with academic focus in neurodegenerative, tumor, medical or any other areas of neuropathology expertise are encouraged to apply. The position will combine clinical duties and academic pursuits (research/teaching) and will be involved in the Longwood Neuropathology Training Program that includes the accredited fellowship program in adult and pediatric surgical and autopsy neuropathology at the Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Children’s Hospital Boston. Candidates would be expected to take advantage of the extensive resources and collaborative interactions within the Brain Tumor Research Program, the Ann Romney Center for Neurologic Diseases, and the Neuroscience Programs of the Harvard Medical School, Dana-Farber Cancer Institute, Brigham and Women’s Hospital, and The Children’s Hospital Boston. Applicants should also have the ability to lead or participate in research in an environment that provides substantial opportunities for clinical/ translational or basic research.


Please send curriculum vitae and names and addresses of three references to

Keith L. Ligon MD, PhD, Director of Neuropathology

c/o Mr. Terry Ott (NP Admin)

Brigham and Women’s Hospital

75 Francis Street

Boston, MA 02115

tott@bwh.harvard.edu


Link: https://www.nature.com/naturejobs/science/jobs/628093-brigham-and-women-s-hospital-academic-neuropathologist
Employer: Brigham and Women's Hospital
Location: Boston, MA
Sector: Academia
Degree required: Board-certified Neuropathologist
Conditions: NDG
Job posted: October 27th, 2017
Brigham and Women's HospitalBoston, MABoard-certified NeuropathologistNDGOct 27, 2017
Clinical Coordinator

Clinical Coordinator

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Description:

The Division of Neuromuscular Disorders is seeking a Research Support Coordinator to join a very active clinical research program with multiple ongoing research studies. The primary focus of the work will be on investigator-initiated research in the fields of amyotrophic lateral sclerosis (ALS) and myasthenia gravis (MG). The research support coordinator will work closely with clinical research coordinators, data manager, statistician, clinical staff and the principal investigator.


*Acquire an in-depth understanding of the research program and the details of specific research projects

*Assist with acquisition and maintenance of IRB approval for research studies as needed, including drafting protocol revisions, writing informed consent documents, developing and updating manual of procedures and case report forms

*Assist with recruitment and enrollment of study participants, coordination of study visits, and collection of study data

*Maintain accurate and complete source documents and case report forms; assist with data entry into research database

*Perform other duties as assigned by the PI.


The minimum qualifications for this position are as follows: Bachelor’s degree. Must be comfortable interacting with study participants and patients via telephone and in person. Excellent organizational as well as verbal and written communication skills are essential. Neuroscience experience is desired. Any appropriate combination of relevant education, certification(s) and/or work experience may be considered.


Link: https://um.hodesiq.com/job_detail.asp?JobID=5519513
Employer: University of Miami
Location: Miami, FL
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: October 27th, 2017
University of MiamiMiami, FLBA or BSALSOct 27, 2017
Assistant or Associate Professor, Neuroscience

Assistant or Associate Professor, Neuroscience

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Description:

The Albert Einstein College of Medicine (Einstein), together with the Montefiore Medical Center, has launched an ambitious Brain Sciences Initiative. As part of this large-scale expansion, the Dominick P. Purpura Department of Neuroscience has recruited a number of outstanding faculty, and will continue to recruit additional faculty in the coming years.


This year, candidates with research interests in all basic, clinical or translational disciplines of neuroscience will be considered for at least two tenure-track positions at the Assistant and Associate Professor level. Applications from exceptional Full Professors will also be considered. Outstanding applicants may be considered for named endowed Chair and endowed Scholar positions. There are also opportunities for co-appointments in clinical departments, particularly through the Psychiatry Research Institute at Montefiore/Einstein (PRIME) initiative, a new multidisciplinary psychiatric research center.


Applicants must have a PhD, MD, or equivalent degree, with a track record of research excellence. Qualified applicants should submit a cover letter, curriculum vitae, and a summary of research accomplishments and goals (maximum 3 pages) to neurosearch@einstein.yu.edu. Applicants should also arrange to have 3 letters of reference sent directly to this email address.


Link: https://jobs.sciencecareers.org/job/468668/assistant-or-associate-professor/
Employer: Albert Einstein College of Medicine
Location: New York, NY
Sector: Academia
Degree required: PhD or MD
Conditions: NDG
Job posted: October 26th, 2017
Albert Einstein College of MedicineNew York, NYPhD or MDNDGOct 26, 2017
Assistant, Associate or Full Professor, Neurobiology

Assistant, Associate or Full Professor, Neurobiology

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Description:

The BARROW NEUROLOGICAL INSTITUTE seeks an exceptionally promising or accomplished investigator to complement other translational neuroscience research in a unique and dynamic environment within the Division of Neurobiology at the Barrow Neurological Institute (https://www.barrowneuro.org/). Qualified applicants holding Ph.D., M.D. or equivalent degrees will be considered for appointment at assistant, associate or full professor levels. The successful candidate will be expected to direct an extramurally-funded research program in neurodegenerative disease research using interdisciplinary approaches. Institutional strategic interests for this position are in Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and traumatic brain injury. Qualified applicants in other areas of translational neuroscience also will be considered. The successful candidate is expected to synergize/collaborate with existing research and clinical faculty, will have access to core facilities and clinical samples, and may leverage opportunities to collaborate with investigators at affiliate institutes including Phoenix Children’s Hospital, the Translational Genomics Research Institute, and the University of Arizona. The successful candidate will receive a highly competitive start-up package and salary support.


Please send either an initial letter of inquiry in confidence or a full application including vita, names and addresses of three references, and brief statements of research experience, interests and career objectives either as hard copies or electronic copies to Neurodegenerative Disease Search, c/o Research Administration, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013 or via e-mail message and pdf or Word attachment to BNI_Research@dignityhealth.org.


Link: https://jobs.sciencecareers.org/job/468220/associate-professor/?LinkSource=PremiumListing
Employer: Barrow Neurological Institute
Location: Phoenix, AZ
Sector: Academia
Degree required: PhD or MD
Conditions: ALS
Job posted: October 26th, 2017
Barrow Neurological InstitutePhoenix, AZPhD or MDALSOct 26, 2017
Research Assistant, Spillantini Lab

Research Assistant, Spillantini Lab

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Description:

Applications are invited for a Research Assistant role to work on a collaborative project between the groups of Professor David Klenerman and Professor Maria Grazia Spillantini to study the molecular basis of neurodegenerative disease.


The work will primarily involve culturing, differentiating and maintaining human iPS cells and iPS-derived neurons but also working with neurons from wild type, transgenic and knockout mouse strains.

The aim of the project is to directly image protein aggregates in neurons to determine how and why aggregates accumulate with time leading to neuronal death.


The successful candidate will have a B.Sc. degree (or equivalent) in a relevant biological science and a strong background in human pluripotent stem cells differentiation and maintenances as well as experience in rodent neuronal cell culture.


Link: https://neuvoo.co.uk/view/?id=ge3g2yn5pp
Employer: University of Cambridge
Location: Cambridge, England
Sector: Academia
Degree required: BS
Conditions: NDG
Job posted: October 26th, 2017
University of CambridgeCambridge, EnglandBSNDGOct 26, 2017
Assistant Professor

Assistant Professor

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Description:

The Department of Biology at the University of Massachusetts, Amherst invites applications for a tenure-track position at the rank of Assistant Professor. The successful candidate will be a part of the Institute for Applied Life Sciences (IALS), which has a primary goal of developing translational research programs and fostering interactions with industry.


We seek highly innovative candidates who are exploring neurological/psychiatric diseases or disorders using clinically relevant animal models, spanning invertebrates to non-human primates. We are particularly interested in candidates whose research focus complements existing departmental and campus strengths, including neuroendocrinology, cytoskeletal dynamics, protein homeostasis, immunology and neurodevelopment. Possible areas of research could include neurodegenerative diseases, stroke, traumatic brain injury, autism or neuropsychiatric disorders. Successful recruits will be expected to establish and maintain a research program with direct relevance to issues of human health and that yield important mechanistic insight into diseases affecting the nervous system.


The new faculty member will collaborate with IALS faculty to translate research results into therapeutic candidates, interact with industry scientists, and provide essential training for the next generation of biomedical scientists. IALS and UMass Amherst are undertaking an aggressive program of faculty recruitment in the next two years. New faculty members will have access to the substantial IALS investments in campus infrastructure and core equipment facilities (see http://www.umass.edu/ials/core-facilities for more details).


Qualified candidates must have a Ph.D. in neuroscience or closely related field, postdoctoral experience, and outstanding potential to establish a translational neuroscience research program. Life sciences faculty members at UMass can recruit students from several interdepartmental graduate programs on campus, and the successful candidate will be expected to participate in teaching at the undergraduate and graduate levels.


Review of applications will begin on November 27, 2017 and will continue until the position is filled. Online applications must include a cover letter, CV, research plan, teaching statement, and the contact information for three references.


Link: http://neurojobs.sfn.org/jobs/10420677/assistant-professor
Employer: University of Massachusetts
Location: Amherst, MA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: October 25th, 2017
University of MassachusettsAmherst, MAPhDNDGOct 25, 2017
Director, Center for Neurodegenerative Disorders (Physician-Scientist)

Director, Center for Neurodegenerative Disorders (Physician-Scientist)

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Description:

The University of Maryland Department of Neurology is seeking a senior level physician scientist with expertise in dementia and neurodegeneration to serve as the Director of the Center for Neurodegenerative Disorders. Specifically, the Department is seeking an investigator with a strong history of external funding whose work focuses on the molecular and cellular pathogenesis of neurodegenerative disorders including Alzheimer’s disease (AD), Huntington’s disease (HD), Fronto-temporal dementia (FTD), or hereditary ataxias (HA).


S/he should have expertise in molecular genetics including whole genome or whole exome screening, SNP or CGA array analysis as a means to identify novel genes that are causative for neurodegenerative disorders in human patients or to screen modifier loci associated with phenotypic variability.


The selected candidate should be clinically trained in cognitive neurology or a related discipline and should be willing to see patients with neurodegenerative disorders such as dementia in the outpatient neurology setting.


For complete details or to apply, contact Lexi Cejka at Lexi.Cejka@grantcooper.com.


Link: https://main.hercjobs.org/jobs/10411320/director-of-center-for-neurodegenerative-disorders-neurology
Employer: University of Maryland
Location: Baltimore, MD
Sector: Academia
Degree required: MD
Conditions: FTD
Job posted: October 25th, 2017
University of MarylandBaltimore, MDMDFTDOct 25, 2017
Research Technician, Morrison and Rothstein Labs

Research Technician, Morrison and Rothstein Labs

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Description:

A Research Technologist to work in the laboratories of Drs. Brett Morrison and Jeffrey Rothstein in the Department of Neurology. Our laboratories study the pathogenesis of the devastating motor neuron disease, amyotrophic lateral sclerosis (ALS; commonly referred to as Lou Gehrig’s disease). A particular focus is on the role played by oligodendrocytes, a key support cell in the brain that is dysfunctional and degenerates in ALS.


Specific duties & responsibilities:


The responsibilities include but are not limited to perform laboratory task following routine and established protocols. Perform lab experiments following protocols. Work collaboratively with the other members of the lab (principal investigators, post-docs, graduate students, and research technicians) on ongoing projects. . In addition to performing laboratory experiments, ongoing responsibilities will include the management of a transgenic mouse colony, assisting the laboratory manager with the ordering of laboratory supplies, and attending all required laboratory meetings. Will have opportunity to pursue new projects independently.


Link: https://jobs.jhu.edu/job/Baltimore-Research-Technologist-MD-21205/437413200/
Employer: Johs Hopkins University
Location: Baltimore, MD
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: October 20th, 2017
Johs Hopkins UniversityBaltimore, MDBA or BSALSOct 20, 2017

Industry

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Principal Scientist, Neuroscience

Principal Scientist, Neuroscience

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Description:

We are seeking a Research Principal Scientist to join a vibrant and growing group currently focusing on developing new and effective therapeutics for neurodegenerative diseases, migraine and neuropathic pain. This position is within the Neuroscience Therapeutic Area, a key component of the Discovery Research unit at Amgen’s site in Cambridge, MA. The Principal Scientist will focus on in vivo model test systems and the development and validation of mechanism based pharmacodynamic measures supporting characterization and pipeline advancement of novel CNS therapeutics.


Link: https://careers.amgen.com/job/7902690/principal-scientist-in-vivo-biology-lead-neuroscience-cambridge-ma/
Employer: Amgen
Location: Cambridge, MA
Sector: Industry
Degree required: BS, MS or PhD
Conditions: ALS
Job posted: December 11th, 2017
AmgenCambridge, MABS, MS or PhDALSDec 11, 2017
Executive Director, Clinical Research, Rare and Neurological Diseases

Executive Director, Clinical Research, Rare and Neurological Diseases

(Click title to open job details in a new window.)
Description:

The Rare Disease Research Unit is looking for a talented senior physician scientist to join our team developing transformational new treatments in rare Neuromuscular, Neurodevelopmental and Neurodegenerative diseases using AAV gene therapy. This individual will focus on the challenging translational, clinical and regulatory problems presented by gene therapy in rare (often) pediatric indications, including natural history studies, novel endpoint development and clinical trial design. The candidate will be accountable for the delivery of translational and clinical development plans for AAV gene therapy programs in multiple rare neurological indications, and will be skilled in early clinical program design and conduct from pre-clinical stages to POC. Similar activities will be required for programs exploiting other treatment modalities. Experience and proven collaborative skills with basic and clinical scientists, investigators, regulators and safety functions are essential.


*Accountable for the development of translational and clinical development plans in rare Neuromuscular, Neurodevelopmental and *Neurodegenerative diseases using AAV gene therapy and other modalities for RDRU projects

*Lead interactions with colleagues in Global Product Development and Pfizer Innovative Health with regard to clinical development planning and product concept development for AAV gene therapies and other modalities.

*Partner with functions in Early Clinical Development as needed to ensure that biomarker and quantitative development plans are enabled in all relevant Rare Neuro programs to help determine early signs of efficacy and proof of concept, patient stratification, etc.

*Serve as a clinical champion for early development Rare Neuro programs in AAV gene therapy and other modalities

*Help to build, develop, and lead motivated and engaged matrix teams

*Provide oversight to clinical teams, including:

*Lead preparation of clinical sections of all relevant regulatory filings (IND, Orphan designation, Fast track and breakthrough designations – including NDA/BLA when required).

*Oversee management of studies and serve as expert on clinical and medical issues, including medical monitoring where necessary

*Oversee review of study data, including safety monitoring and SAE reporting

*Oversee writing of final study reports and preparation of documents for submission

*Establish and support relationships with external experts, consultants, key opinion leaders, to ensure implementation of latest clinical thinking and guidelines into clinical development plans and study designs

*Serve as medical and technical resource for clinical issues raised by internal and external collaborators, investigators, consultants and contractors

*Mentor or supervise other clinicians to expand drug development understanding and provide development opportunities

*Foster a transparent environment that encourages strong partnerships and mutual trust between teams, sub-teams, and therapeutic areas.

*Represent the company at scientific meetings and presentations, interactions with rare disease foundations, as well as other public relations opportunities

*Assist in the development of publications, abstracts, and presentations

*Support business development activities as needed, including due diligence activities.

*Maintain up-to-date knowledge of scientific and clinical published literature in relevant therapeutic areas including the key clinical development issues.


Link: https://pfizer.wd1.myworkdayjobs.com/en-US/PfizerCareers/job/United-States---Massachusetts---Cambridge/Executive-Director-Clinical-Research-Rare-Neurological-Disease--MD-Required-_1623774?source=Linkedin
Employer: Pfizer
Location: Cambridge, MA
Sector: Industry
Degree required: MD or MD/PhD
Conditions: NDG
Job posted: November 29th, 2017
PfizerCambridge, MAMD or MD/PhDNDGNov 29, 2017
Scientist I/II

Scientist I/II

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Description:

Neurology Research at Biogen seeks a highly motivated and experienced associate scientist to join the new initiative on ALS (amyotrophic lateral sclerosis). The Neurology department is responsible for discovery research on pathogenic mechanisms of neurodegenerative disorders and translating these findings into novel strategies for therapeutic intervention.


The successful candidate will execute in vivo experiments to support the validation of novel drug targets and the development of small- and large-molecule drugs for the treatment of ALS. A major component of this work will be the assessment of drug candidates in a multiple rodent models, using a wide variety of morphological and functional endpoints, working closely with members of the ALS team as well as multiple internal and external collaborators. You will work in a fast paced, highly collaborative team environment at an exciting period for ALS research.


Qualifications

• Familiarity with genetic models of neurodegenerative diseases and experience with conducting either pharmacological or genetic tests in those models

• Must demonstrate a keen knowledge of experimental design, underlying scientific principles, and the ability to rigorously analyze and assess results and generate clear reports

• Previous experience handling animals is required and should include some of the following: dosing, dissection, and/or surgery. Neo natal rodent survival surgery strongly desired.

• Experience in histopathological techniques, such as perfusion, cryostat sectioning, immunostaining is strongly preferred

• Experience in molecular biology and biochemical techniques, such as DNA cloning, electrophoresis, and PCR is preferred

• Experience with behavioral or electrophysiological endpoints would be a positive addition

• Excellent communication and organizational skills are critical.


Link: https://sjobs.brassring.com/TGnewUI/Search/home/HomeWithPreLoad?PageType=JobDetails&noback=0&partnerid=169&siteid=5140&jobid=793781#jobDetails=793781_5140
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: ALS
Job posted: November 29th, 2017
BiogenCambridge, MAPhDALSNov 29, 2017
Senior Scientist

Senior Scientist

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Description:

Yumanity is seeking a creative, talented and versatile Ph.D scientist to join our interdisciplinary team to help advance our novel drug discovery programs. This position will be laboratory based, and requires strong experimental skills in neurobiology and assay development. The scientist in this position will collaborate across all Yumanity’s core platforms, including yeast phenotypic screening, target identification and chemistry.


Responsibilities include:


*Developing neurodegenerative disease models in mammalian cells including cell lines, rodent primary neurons and human iPS cell-derived neurons.


*Developing assays to validate the activity and target of the compounds derived from yeast high-throughput screening.


*Interacting and collaborating with yeast screening, target ID and medicinal chemistry teams to validate compound and target activities in mammalian cells.


Experience and skills required:


*Education: Ph.D. degree in neuroscience, cell biology, biochemistry, or relevant field with 2+ year of postdoctoral experience.


*Highly desirable to have experience in modeling neurodegenerative diseases in neurons using misfolding-prone proteins such as alpha-synuclein, APOE4 and others, skills in developing and miniaturizing assays to measure cellular responses to pathologic processes, highly versatile and team-based mindset.


*Excellent verbal, written communication and presentation skills are essential.


Link: https://www.linkedin.com/jobs/view/462507144/
Employer: Yumanity Therapeutics
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: November 28th, 2017
Yumanity TherapeuticsCambridge, MAPhDNDGNov 28, 2017
Senior Scientist

Senior Scientist

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Description:

Evotec’s headquarters in Hamburg (Germany) is seeking a highly motivated and creative Senior Scientist (f/m) Biomarker in Neurodegeneration Research full-time and permanent to join our Neurobiology Department and help drive projects in the research area of Huntington’s Disease and other neurodegenerative disorders.


Your key responsibilities:

*Manage, lead biomarker projects and provide scientific expertise to other ongoing projects of the Biomarker group

*Support the group leader with people and scientific management and business development

*Actively contribute to and support collaborative initiatives and liaise with external scientists and customers

*Train and supervise a small team of technical staff to design and execute immunoassay development, cellular and biochemical assays

*Design, develop, implement and validate in vitro and biochemical and immuno-assays on various technology platforms including ELISA, MSD, Singulex and hTRF to evaluate efficacy, PK/PD relationship, and novel biomarkers to characterize molecules for potential therapeutic effects

*Analyze and summarize data for presentations, reports, publications and patents


Link: https://www.linkedin.com/jobs/view/527410471/
Employer: Evotec
Location: Hamburg, Germany
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: November 24th, 2017
EvotecHamburg, GermanyPhDNDGNov 24, 2017
Sr. Clinical Scientist

Sr. Clinical Scientist

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Description:

The Sr. Clinical Scientist will work with the Medical Director functions of Early Clinical Development teams and provide scientific and clinical input into early stage clinical development programs. This role will work on cross-functional study teams for the design, execution, and monitoring of clinical trials, early clinical research studies, and/or external research projects, as well as assist with data interpretation and communication.. This individual will report directly into a Sr. Medical Director of Clinical Development or a Therapeutic Area VP and will interface directly with other functions including Clinical Development, Clinical Pharmacology, and Biomarkers.


Link: https://jobs.biogen.com/job/Cambridge-Sr_-Clinical-Scientis%2C-Neurodegeneration-and-Repair-Research-Unit-MA-02138/421188900/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD or PharmD
Conditions: NDG
Job posted: October 26th, 2017
BiogenCambridge, MAPhD or PharmDNDGOct 26, 2017
Sr. Associate Scientist, Neurobiology

Sr. Associate Scientist, Neurobiology

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Description:

The Neurodegeneration and Repair Research Unit is seeking a motivated and experienced scientist to join a group a cutting edge research group focused on the rapid progression of novel therapeutics for neurodegeneration. The successful candidate will join a highly productive team that has established robust in vivo and in vitro assays, in support of project and company drug discovery and development goals.


Responsibilities: The ideal candidate will perform primary neuronal cell culture, immunochemistry chemistry staining, and animal experiments relevant for neurological disorders. The candidate should be able to design, execute and troubleshoot experiments and to analyze and interpret results. Document and communicate work clearly and concisely, may participate in writing manuscripts, scientific reports, and patents.


Link: https://jobs.biogen.com/job/Cambridge-Sr-Associate-Scientist%2C-Remyelination-and-Repair%2C-Research-MA-02138/415533200/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: BA or BS
Conditions: NDG
Job posted: October 24th, 2017
BiogenCambridge, MABA or BSNDGOct 24, 2017
Director/Sr. Director, Neurodegeneration and Repair Research

Director/Sr. Director, Neurodegeneration and Repair Research

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Description:

We are looking for a talented leader to direct preclinical research in Dementia and Memory Disorders within the new Neurodegeneration and Repair Research Unit. In close partnership with the early clinical lead for within the same unit, the successful candidate will be responsible for delivering innovative drug candidates for proof-of-concept trials in AD, FTD and other memory disorders. He/she will lead the efforts of multiple research teams from early target discovery to late preclinical development and support the clinical trial strategy. We seek a candidate with knowledge of the biology of neurodegeneration and an outstanding track record in the field of drug development. He/she will succeed by collaborating closely with other Biogen scientists and clinicians in the areas of neurodegeneration, neuroimmunology and repair, as well as experts in the multiple therapeutic modalities – small molecules, antibodies, biologics, antisense oligonucleotides and gene therapy – in the Biogen portfolio. An innovative approach to biomarker and drug delivery strategies will also be required. We particularly seek candidates who have demonstrated strong scientific rigor while exploring novel pathways and mechanisms in humans and model systems and in leading multidisciplinary research teams. Demonstrated expertise in Alzheimer’s research and experimental models would be an advantage but is not required.


Link: https://jobs.biogen.com/job/Cambridge-DirectorSr_Director%2C-Neurodegeneration-and-Repair-Research-MA-02138/374546100/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD or PhD/MD
Conditions: FTD
Job posted: October 23rd, 2017
BiogenCambridge, MAPhD or PhD/MDFTDOct 23, 2017

Non-Profit and Government

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
Senior Scientist

Senior Scientist

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Description:

LifeArc is the new name for MRC Technology, a medical research charity with a 25 year legacy of helping scientists and organisations turn their research into treatments and diagnostics for patients. LifeArc is pioneering new ways to turn great science into greater patient impact. It brings together a network of partners to tackle specific diseases and directly funds academic and early stage research.


Our Centre for Therapeutics Discovery (CTD) in Stevenage operates at the interface between academic research and the drug discovery industry. We take novel academic targets and generate lead stage small molecules and therapeutic antibodies for indications with unmet medical need.


The Biology Group supports both small molecule and antibody projects, working closely with our Chemistry and Biotherapeutics Groups. We are looking for a Senior Scientist to provide support for our on-going drug discovery projects in the neuroscience disease area. You will be a Post-Doctoral Scientist with several years’ relevant laboratory experience in neurodegeneration and/or neuroinflammation with practical experience in relevant cell and molecular biology techniques, primary neuronal/glial culture and immune cell culture. Good knowledge of neurodegenerative disease and inflammatory pathways would be advantageous. It would be highly beneficial to have experience in drug discovery and line management although this is not essential.


As part of a project team and collaborating with internal and external scientists, you will independently design and perform target validation experiments and cell-based assays suitable for the profiling of compounds and/or antibodies. You should also be sufficiently experienced to lead on the scientific rationale and to propose novel avenues of research to progress the project. You are likely to be working on more than one project at any one time.


To apply please email your CV and covering letter explaining why you want to work for LifeArc to: recruitment@lifearc.org or by post to Recruitment, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX (electronic applications preferred).


Link: https://www.nature.com/naturejobs/science/jobs/628189-senior-scientist-biology
Employer: LifeArc (MRC Technology)
Location: Stevenage, England
Sector: Non-Profit
Degree required: PhD
Conditions: NDG
Job posted: October 30th, 2017
Applications close: November 17th, 2017
LifeArc (MRC Technology)Stevenage, EnglandPhDNDGOct 30, 2017
Director, Division of Neuroscience

Director, Division of Neuroscience

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Description:

The National Institute of Neurological Disorders and Stroke (NINDS) seeks a Director to lead its extramural Division of Neuroscience. The Director of the Division of Neuroscience will be responsible for planning and directing a program of extramural and collaborative research in neuroscience, guiding NINDS’s largest research portfolio and charting the future of a vibrant, growing neuroscience research community https://www.ninds.nih.gov/. The Director of the Division of Neuroscience will lead a group of approximately 60 professional staff. The research portfolio of the Division of Neuroscience includes an annual budget of over $1 billion dollars in grants and over $30 million in R&D contracts.


Applicants should submit a current curriculum vitae, bibliography, full contact details for three (3) references, and prepare two statements: a vision statement and a statement that addresses the specific qualification requirements (please limit each statement to two pages) to Joanne Pomponio jpomponio@ninds.nih.gov. Review of applications will begin on December 15, 2017 and applications will continue to be accepted and considered until the position is filled. You may contact David Shurtleff, Ph.D., Search Committee Chair, with questions and for more information about this vacancy at dshurtle@mail.nih.gov or (301) 435-0891.


Link: https://jobs.sciencecareers.org/job/467867/ninds-director-division-of-neuroscience-nih-ninds-/
Employer: NINDS
Location: Bethesda, MD
Sector: Non-Profit
Degree required: PhD or MD
Conditions: NDG
Job posted: October 20th, 2017
NINDSBethesda, MDPhD or MDNDGOct 20, 2017
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