Figure 3. Expression of oligodendrocyte-specific cell type markers in F3.Olig2 cells and expression of motor neuron-specific cell type markers in F3.Olig2-Shh cells.
Image credit: Lee, et.al. 2014 under CC BY license

Job Opportunities

To submit any new job opportunities for this list, please email alsresearchforum@prize4life.org. List the employer, location, closing date if applicable, and a link to more information. Jobs are removed after 3 months, unless requested otherwise.

This free job bulletin board aims to help scientists identify job opportunities in the field of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Positions described as broadly spanning neurodegenerative diseases (NDG) are noted as ‘NDG‘. The job listing includes research positions at all levels, as well as non-research positions for which a research background at the MS, PhD, or MD level is required.


Click the title of any table column to sort.

Academia

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Biostatistician, Research Fellow

Biostatistician, Research Fellow

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Description: Applications are invited for a motivated and self-driven individual for the position of Biostatistician with the Irish ALS Research Group, hosted in the Trinity Biomedical Sciences Institute's Academic Unit of Neurology. This project will combine high resolution structural and dynamic imaging of the brain at 3 Tesla and spectral EEG/ EMG with clinical and genomic data to identify sub-clusters of ALS patients.

Using robust mathematical models and building on key imaging and signal processing signatures we will develop observed-independent, quantitative markers of disease that can be utilized to generate disease clusters. These clusters will then be further analysed based on discriminatory clinical, neuropsychological and genomic data.

The ideal candidate will have a PhD in Biostatistics or a cognate area.

Link: http://jobs.sciencecareers.org/job/425200/research-fellow-biostatistician/
Employer: University of Dublin
Location: Dublin, Ireland
Sector: Academia
Degree required:
Conditions: ALS
Job posted: September 24th, 2016
University of DublinDublin, IrelandALSSep 24, 2016
Postdoctoral Position

Postdoctoral Position

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Description: The Cedars-Sinai Regenerative Medicine Institute has a Research Postdoctoral position available to study the molecular mechanisms of neurodegeneration, with particular focus on axon degeneration in inherited peripheral nerve diseases, including demyelinating peripheral nerve disease. Candidate must be experienced with performing techniques ranging from neuronal and stem cell culture, molecular biology and bioinformatics (RNA-seq, exome seq), biochemistry and cell biology.

This is an excellent opportunity to work with a multidisciplinary group of neurologists, molecular biologists, and neurogeneticists interested in understanding neurodegeneration with the goal of developing therapies. The primary focus of the candidate will be working with patient derived iPS cell lines, genetically engineering them using CRISPR technology, molecular and genomic characterization including exome sequencing, and differentiating them into motor neurons and Schwann cells to investigate cell replacement therapies for patients.

Qualification Requirements/Preferences:
Doctorate (MD, PhD, VMD, or DDS) in area directly related to field of research specialization

Additional Information:
Scheduling flexibility including evening, weekend and holiday rotation commitment is required. Excellent written and oral communication skills are essential. Travel may be required.

Link: https://www.cedars-sinaimedicalcenter.apply2jobs.com//ProfExt/index.cfm?fuseaction=mExternal.showJob&RID=23283&CurrentPage=41&sid=69
Employer: Cedar-Sinai Regenerative Medicine Institute
Location: Los Angeles, CA
Sector: Academia
Degree required:
Conditions: ALS
Job posted: September 11th, 2016
Cedar-Sinai Regenerative Medicine InstituteLos Angeles, CAALSSep 11, 2016
Faculty Position- Pharmacology

Faculty Position- Pharmacology

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Description: The Department of Pharmacology at the University of Colorado School of Medicine Anschutz Medical Campus is seeking applicants to fill a tenure-track faculty position at the Assistant Professor level in the areas of neuroscience and neuropharmacology. The research of the applicant should emphasize molecular and cellular mechanisms of nervous system function that are broadly related to understanding human nervous system diseases and/or the actions of existing drugs or the development of new drugs and therapies to treat neurological and neuropsychiatric disorders, including neurodegeneration.

In particular, we seek applicants whose research would complement our existing strengths in studying regulation of neurotransmitter receptors, ion channels, cell adhesion molecules, kinase and phosphatase signal transduction, and gene expression in control of neuronal activity and synaptic plasticity. We also seek applicants who employ a variety of innovative experimental approaches including: molecular and cellular imaging, electrophysiology, optogenetic and chemical genetic control of neuronal function, neurobehavioral testing, genomic, transcriptomic and proteomic analyses.

Applicants should also be enthusiastic about teaching medical and graduate students, serving as research mentors in graduate and postdoctoral training programs in pharmacology and neuroscience.

Applicants must have a PhD and/or MD degree and appropriate and sufficient post-doctoral experience

Link: https://cu.taleo.net/careersection/2/jobdetail.ftl?job=80886
Employer: Univ. of Colorado- Anschutz Medical Campus
Location: Aurora, CO
Sector: Academia
Degree required:
Conditions: NDG
Job posted: September 3rd, 2016
Applications close: October 15th, 2016
Univ. of Colorado- Anschutz Medical CampusAurora, CONDGSep 03, 2016
Postdoctoral Position – Sher Lab

Postdoctoral Position – Sher Lab

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Description: A Postdoctoral Associate position is available in the lab of Roger Sher in the Department of Neurobiology and Behavior at Stony Brook University. The postdoc will assist the Principal Investigator in studying nucleocytoplasmic transport and motor neuron disease. The Postdoctoral Associate will use cell culture, motor neuron culture, plasmid transfection, transgenesis technology (transgene expression, CRISPR.Cas9) and confocal microscopy to understand how mutations in a candidate gene suspected in ALS alter nuclear transport and cell viability. The incumbent will conduct research and ensure that all experiments are appropriately conducted following the policies and procedures of Stony Brook University, and will be responsible for the following:

Preferred Qualifications:
-PhD in Neuroscience
-Experience with cell culture, human iPS derived motor neuron culture, zebrafish and/or rodents.

Brief Description of Duties:
-Participate/assist in manuscript writing for publication in scientific journals and/or presentations. May also assist in grant writing.
-Lab maintenance, including equipment maintenance, mouse care and ordering of supplies as needed.
-Other duties or projects as assigned, which may include attending scientific meetings.

Link: https://stonybrooku.taleo.net/careersection/2/jobdetail.ftl?job=1601924
Employer: Stony Brook University
Principal investigator: Roger Sher
Location: Stony Brook, NY
Sector: Academia
Degree required: PhD
Conditions: ALS, NDG
Job posted: September 3rd, 2016
Applications close: September 30th, 2016
Stony Brook UniversityStony Brook, NYPhDALS, NDGSep 03, 2016
Postdoctoral Position – Institute of Healthy Aging (IHA)

Postdoctoral Position – Institute of Healthy Aging (IHA)

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Description: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating, mid-life, neurodegenerative disorders for which no cure is currently available. Large expansions of a hexanucleotide GGGGCC-repeat in the first intron of the C9orf72 gene is the most common genetic cause of both ALS and FTD. We recently developed novel Drosophila models of C9orf72 repeat-induced neurodegeneration (Mizielinska et al Science 2014, 345:1192-1194). This 3-year post-doctoral position will build on this work by investigating disease mechanisms in a range of C9orf72 fly lines using several approaches including genome-wide transcriptomic and translational analyses in both flies and iPSC-neurons. You will work as part of a collaborative team of investigators in an excellent and supportive scientific environment. Research community of GEE and UCL, which will provide additional mentorship and training activities. This post is funded for 3 years in the first instance by Alzheimer’s Research UK and is available from October 2016.

The successful candidate must hold (or be close to obtaining) a PhD degree in relevant subject area (i.e. Drosophila biology) and have proven knowledge of research techniques and methodologies such as Drosophila genetics and maintenance as well as Drosophila molecular biology. Proven knowledge of Drosophila neurobiology, modifier screens and ribosomal profiling is desirable. Demonstrable comprehensive knowledge in the subject area as well as proven ability to analyse and write up data are essential. The post holder must also demonstrate commitment to high quality research and ability to work both collaboratively and independently. Please note: Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at research assistant Grade 6B (salary £29,485 – £31,091 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis (including corrections).

For further details about the vacancy and how to apply online please go to http://www.ucl.ac.uk/hr/jobs/ and search on Reference Number 1570446

For informal queries on the role please contact Mr Michael Wright at michael.wright@ucl.ac.uk . For any queries regarding the application process, please contact Biosciences Staffing team onbiosciences.staffing@ucl.ac.uk and quote the reference 1570446.

Link: https://goo.gl/GAepfg
Employer: University College London
Location: London, UK
Sector: Academia
Degree required:
Conditions: ALS, FTD
Job posted: August 22nd, 2016
Applications close: September 21st, 2016
University College LondonLondon, UKALS, FTDAug 22, 2016
Faculty Position – Department of Pathology

Faculty Position – Department of Pathology

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Description: The Department of Pathology at the Yale School of Medicine is seeking applications for up to three full-time appointments at the Assistant or Associate Professor level (Ph.D. or M.D./Ph.D.) to build an interdisciplinary research program in the new Yale Center for Research on Aging (Y-Age). The Center is largely housed in the Department of Pathology but will have strong ties with other Yale School of Medicine Departments and Centers and the Yale University community.

Successful candidates will be expected to establish a competitive and impactful research program in the basic biology of aging but with an eye on translation of findings into the role of aging in neurodegeneration, inflammatory processes, metabolic disorders, or cancer. Other responsibilities will include contributions to Yale’s teaching and service missions and, if appropriate, its clinical programs.

Appointment to the faculty of the Yale School of Medicine and the Graduate School of Arts and Sciences will be at a rank commensurate with accomplishments and experience.

Southern Connecticut offers beautiful shoreline, affordable housing, excellent schools, numerous recreational opportunities, and easy access to New York, Boston, Newport, Cape Cod, and the ski slopes of New England.

All application materials must be uploaded through the following Interfolio website: https://apply.interfolio.com/36112. These include a curriculum vitae, a two-page summary of the candidate’s current and proposed research program, and letters of recommendation from three senior references who are familiar with their work and accomplishments.

Specific inquiries can be directed to Gerald S. Shadel, Ph.D., Director: Yale Center for Research on Aging, Yale School of Medicine, 310 Cedar Street, New Haven CT 06510 by e-mail to gerald.shadel@yale.edu.

Initial deadline is December 1, 2016, but the search will remain open until positions are filled.

"Yale University is an Affirmative Action/Equal Opportunity Employer and welcomes applications from women, persons with disabilities, protected veterans and members of minority groups."

Link: http://jobs.sciencecareers.org/job/418566/assist-assoc-professor/
Employer: Yale University School of Medicine
Location: New Haven, CT
Sector: Academia
Degree required:
Conditions: NDG
Job posted: August 16th, 2016
Applications close: December 1st, 2016
Yale University School of MedicineNew Haven, CTNDGAug 16, 2016
Faculty Position – Dept. of Neuroscience

Faculty Position – Dept. of Neuroscience

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Description: The Department of Neuroscience at Mayo Clinic in Jacksonville, FL, is seeking outstanding candidates with dynamic research programs in neurobiology of disease and aging. The ideal candidate for this position will be an investigator with an innovative and dynamic research program that is directed at understanding the fundamental role of disease biology in neurodegenerative disease including Alzheimer’s disease, Parkinson’s disease, Frontotemporal dementia, and Amyotrophic Lateral Sclerosis. Specific areas of interest include cerebrovascular disease, CNS immunity, neurobiology of aging, stem cell biology, neurodegeneration and neuroregeneration across a range of neurological disorders. We are seeking a world-class researcher to participate in departmental and institutional initiatives emphasizing collaboration and team science.

The candidate for this position will be expected to have a track record of major contributions to the field, with an emphasis on the application of novel in vitro and in vivo imaging tool and animal models, induced pluripotent stem cells, the use of systems level analytical and bioinformatics approaches, or the integration of multiple discovery platforms to advance our understanding of disease biology and etiology. The candidate for this position is expected to have a history of extramural funding, as well as a proven record of collaborative team science endeavors. Individuals with interest and experience in research training and graduate-level education are particularly encouraged to respond.

The Mayo Clinic Department of Neuroscience is a prominent neuroscience department and is internationally recognized and respected for academic excellence. Basic scientists within the neuroscience department have strong expertise in neurogenetics, neuropathology, disease modeling, immunity, and experimental therapeutics. The Department hosts an NIH-designated Alzheimer’s Disease Research Center and the Udall Center of Excellence for Parkinson's Disease Research. The research mission of the department is closely aligned with the resources and initiatives of the Center for Biomedical Discovery, Center for Regenerative Medicine, Center for Individualized Medicine, Department of Neurology, and the Center on Aging. The department also has an outstanding training environment and is closely aligned with the Neurobiology of Disease Program at Mayo Graduate School, the Mayo Medical School and the Mayo School of Graduate Medical Education.

Mayo Clinic is ranked number one in more specialties than any other hospital in the nation for 2015-2016 by U.S. News and World Report. We are an integrated, multidisciplinary academic medical center with comprehensive programs in medical education and research that span across three group practice sites. We support a dynamic research enterprise, with programs in basic, translational, clinical, and population sciences. In 2014, the institution received nearly $371 million in extramural research awards, supplemented with over $276 million of institutional support. Mayo Clinic has a large number of world class faculty laboratory and state-of-the-art shared resource facilities, including those for microscopy and imaging, cell and molecular biology, animal models, production of iPS cells and clinical grade MSCs, biomedical engineering and mathematics, materials testing, a Medical Genomics Facility, a Mouse Modeling Facility, Molecular and Microscopic Core Facilities, and unique Human Disease Tissue Banks. We offer a highly competitive compensation package with sustained intramural funding, capital equipment funding, technical and computational resources, and exceptional benefits.

Applications should include a CV, NIH biosketch, a description of current research focus and funding, and the names/contact information of five references. For questions about the position, please contact: Leonard Petrucelli, MD, PhD c/o semko.adriana@mayo.edu

Link: https://physicians.mayo-clinic-jobs.com/job/Jacksonville-Faculty-Position-in-the-Department-of-Neuroscience-Job-FL-32099/313705900/
Employer: Mayo Clinic
Location: Jacksonville, FL
Sector: Academia
Degree required:
Conditions: ALS, FTD, NDG
Job posted: August 16th, 2016
Mayo ClinicJacksonville, FLALS, FTD, NDGAug 16, 2016
PhD Position – Motor Neuron Disease

PhD Position – Motor Neuron Disease

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Description: An exciting opportunity has arisen for a PhD project in the field of neuroimaging in motor neuron disease (MND). MND is a devastating, fatal, incurable neurodegenerative condition that typically results in death within 2-3 years. Therapeutic efforts have been limited by an incomplete understanding of disease pathophysiology, and because an available biomarker is lacking with which to track therapeutic effects over short timescales; for this reason, many potential agents never make it to clinical trial. There is increasing evidence for abnormal energy metabolism in MND, both a hypermetabolic early phase characterised clinically by weight loss and, later, mitochondrial failure, which may contribute to motor neuronal cell death.

The aim of the present project is to investigate energy dynamics longitudinally in patients with MND in vivo, both in brain and muscle, using 31-phosphorus magnetic resonance spectroscopy (31-P MRS), a cutting edge non-invasive technique to quantify energy metabolites in living tissue. Correlations will be made with clinical and electrophysiological measures. The hypothesis is that derived 31-P paremeters will demonstrate dynamic changes over the course of the disease: an initial phase of hypermetabolism will be followed by evidence of mitochondrial failure, in contrast to healthy control subjects, in whom energy parameters will remain constant. The project will advance our understanding of the role of energy metabolism in MND and evaluate the potential of 31-P MRS as a biomarker.

The successful candidate would join the world-renowned MND research team at the Sheffield Institute for Translational Neuroscience (SITraN). Experience in neuroimaging analysis methodology would be advantageous. Excellent verbal and written communication skills, empathy, an inquiring scientific mind and the ability to take ownership of a project with appropriate support and deliver results to deadline are essential attributes.


Link: http://goo.gl/KTz586
Employer: University of Sheffield
Location: Sheffield, UK
Sector: Academia
Degree required:
Conditions: ALS
Job posted: August 16th, 2016
University of SheffieldSheffield, UKALSAug 16, 2016
Postdoctoral Position – Center fro Bionic Medicine

Postdoctoral Position – Center fro Bionic Medicine

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Description: The Single Motor Unit Laboratory (SMPP) strives to understand how the nervous system controls individual motor units within a muscle so as to enable the generation of muscle force. Seeks to investigate the role of intrinsic properties of motoneurons that innervate relevant muscle fiber populations in providing such control under normal conditions and following such illnesses as stroke, spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS). The PostDoc Fellow will be responsible for the design, execution and interpretation of experiments within a laboratory team environment and a larger laboratory research program of engineers, physical therapists and neuroscientists focused on sensory motor performance and rehabilitation within a major, nationally leading Academic Rehabilitation Hospital.
The PostDoc Fellow consistently demonstrates support of the RIC statement of Mission and Philosophy by striving for excellence, contributing to the team efforts and showing respect and compassion for patients and their families, fellow employees, and all others with whom there is contact at or in the interest of the institute. The PostDoc Fellow demonstrates RIC Core Attributes: Communication, Accountability, Flexibility/Adaptability, Judgment/Problem Solving, Customer Service and RIC Values (Hope, Compassion, Discovery, Collaboration, & Commitment to Excellence) while fulfilling job duties.

Principal Responsibilities
The PostDoc Fellow will participate in the discovery and evaluation of candidate targets affecting motor unit function and subsequent sensory motor performance following stroke, SCI, and/or ALS. The PostDoc Fellow may also be expected to study the effects of various clinical interventions in order to aid the design of rehabilitation strategies targeting specific motor unit properties.
- Design, execution and interpretation of experiments for the discovery of critical information in motor unit biology as it relates to the condition of-, or recovery from stroke, SCI and/or ALS.
- Independent leadership of research projects in a team environment
- Participates in regular development meetings with supervising team members.
- Keeps informed of developments in field to maintain and enhance professional expertise; offers suggestions regarding continuing development of program.
- Participates in research activities.

Reporting Relationships
Reports directly to assigned Research Scientist or Principal Investigator.

Knowledge, Skills & Abilities Required

  • PhD degree in Biological or engineering Sciences.

  • Excellent oral and written communication skills.

  • Less than 5 years of postdoctoral training.

  • Proficiency in the use of current electrophysiology and/or nerve conduction techniques and analyses, use of electromyography, kinematic measurements including active range of motion, peak velocity, peak acceleration, movement smoothness, and movement speed; and kinetic parameters, including isometric voluntary contraction and clinical measurements of motor impairment.

  • General knowledge or interest in rehabilitation and/or bio- or mechanical engineering principles.

  • Experience working with stroke, SCI or ALS subjects.

  • Experience with clinical assessments related to movement (ie FIMS).

  • Experience using or developing computer models is a plus.



Link: https://ricc-hr.silkroad.com/epostings/index.cfm?fuseaction=app.dspjob&jobid=177216
Employer: Rehabilitation Institute of Chicago
Location: Chicago, IL
Sector: Academia
Degree required:
Conditions: ALS
Job posted: August 16th, 2016
Rehabilitation Institute of ChicagoChicago, ILALSAug 16, 2016
Postdoctoral Position – Thompson Lab

Postdoctoral Position – Thompson Lab

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Description: The University of California, Irvine s Institute for Memory Impairments and Neurological Disorders has an opportunity for a postdoctoral position within the laboratory of Leslie Thompson to work on projects related to Amyotrophic lateral sclerosis and Huntington s disease, induced pluripotent stem cells, blood brain barrier, transcriptomics and bioinformatics. This position requires a Ph.D. degree in one of the following disciplines: neuroscience, biochemistry, immunology, or stem cell biology. A major focus of this position will be to use pateint-derived induced pluripotent stem cells to identify cell signatures in differentiated neuronal subtypes. Prior experience in stem cell culture, differentiation of iPSCs into astrocytes, neuronal subtypes and brain endothelial cells is important. Further, a working knowledge of transcriptomics and subsequent bioinformatic analysis is required. Candidates should have a record of completed graduate research that can be directly applied to the fields of interest listed above. The successful candidate must have a strong publication record and also have a broad range of skills, including the ability to maintain effective interactions and collaborations with other members of the lab, the Institute and outside collaborators. The position will be appointed at the level that is commensurate with the education and experience of the individual candidate and is for a period of one year with the possibility of renewal. Applications from members of ethnic and racial minority groups are encouraged to apply and all applications will be reviewed until the position is filled.

Application Procedure:
Please submit a letter of interest, curriculum vitae which should include a record of research experience and the names of three references before 8/31/2016 to: https://recruit.ap.uci.edu/apply/JPF03659

Link: https://recruit.ap.uci.edu/apply/JPF03659
Employer: University of California
Principal investigator: Leslie Thompson
Location: Irvine, CA
Sector: Academia
Degree required:
Conditions: ALS
Job posted: August 16th, 2016
Applications close: August 31st, 2016
University of CaliforniaIrvine, CAALSAug 16, 2016
Postdoctoral Positions – Institute for Genomic Medicine

Postdoctoral Positions – Institute for Genomic Medicine

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Description: Multiple postdoctoral positions in Precision Medicine in Columbia's Institute for Genomic Medicine.

The Institute for Genomic Medicine (IGM) at Columbia University Medical Center is a unique interdisciplinary research environment specializing in human genetics and genomics. The IGM uses next generation sequencing technologies to sequence 10K individuals per year, has cutting-edge programs developing cellular and animal models of human disease, and generates over 30 million dollars per year in research funding. Postdoctoral researchers are typically supervised by multiple faculty members, offering unique opportunities for integrating basic and translational research. The Institute is actively recruiting postdoctoral research scientists to be at the forefront of the rapidly expanding field of precision medicine and therapeutic discovery in the following areas:

Bioinformatics/Statistical Genetics
Working with an interdisciplinary team of investigators, the successful candidate will have primary responsibilities focused the development of novel approaches of analyzing next generation sequence data and rich phenotypic information from tens of thousands individuals to identify disease associated genomic loci and to study patterns of mutations genome-wide to discern pathogenic and benign mutations in individuals. A suitable candidate should have a doctoral degree in a quantitative field, such as bioinformatics, computational biology, statistical genetics, biostatistics or computer science, and have sufficient experience in algorithm development and scientific programming.

The successful candidate will be supervised by Drs. David Goldstein, Kai Wang, Matt Harms, and/or or Erin Heinzen (or a combination thereof), and have significant interactions with other faculty and scientists within the Institute and within the broader Columbia and NYC research community.

Human genetics/Precision Medicine
Working with an interdisciplinary team of investigators, the successful candidate will have primary responsibilities focused on the analysis and interpretation of genetic variation and detailed phenotypic information from patients with a range of disorders, including epilepsy, amyotrophic lateral sclerosis, schizophrenia, rare severe pediatric disorders and beyond, collected through the Columbia Precision Medicine Initiatives. A suitable candidate should have a doctoral degree in human genetics or a related field, and have extensive experience analyzing genomic datasets.

The successful candidate will be supervised by Drs. David Goldstein, Kai Wang, Matt Harms, and/or Erin Heinzen (or a combination thereof), and have significant interactions with other faculty and scientists within the Institute and within the broader Columbia and NYC research community.

Experimental genetics
The successful candidate will work with an interdisciplinary team of investigators to study mouse and cellular models of neurological disease in order to reveal the pathogenic mechanisms of epilepsy and other neurological diseases. A suitable candidate should have a doctoral degree in functional biology, and specifically in in vivo and/or in vitro human disease models.

The successful candidate will be co-supervised by Drs. David Goldstein, Wayne Frankel, Mike Boland, and/or Erin Heinzen (or a combination thereof), and have significant interactions with other faculty and scientists within the Institute and within the broader Columbia and NYC research community.

Link: http://academicjobs.columbia.edu/applicants/Central?quickFind=63256
Employer: Columbia University
Location: New York, NY
Sector: Academia
Degree required:
Conditions: ALS
Job posted: August 16th, 2016
Columbia UniversityNew York, NYALS Aug 16, 2016
Research Associate – Taylor Lab

Research Associate – Taylor Lab

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Description: The Howard Hughes Medical Institute is seeking a highly motivated Research Specialist to join Dr. J. Paul Taylor’s group at St. Jude Children’s Research Hospital. The primary focus of this position will be the use of Drosophila melanogaster as a tool to investigate the molecular genetics of neurological diseases.

For more information about the work in Dr. Taylor's laboratory, please visit us at: http://www.hhmi.org/scientists/j-paul-taylor

Click on the link below to apply for this position. Please submit a cover letter and three letters of reference along with your resume/CV. No phone calls please.

Representative Essential Duties and Responsibilities:
To elucidate the pathogenic mechanisms underlying genetic forms of amyotrophic lateral sclerosis and related diseases using a wide range of approaches including molecular biology, genetics, biochemistry, behavior, and state of the art imaging.

Preferred Qualifications:
PhD in/or Neuroscience, Genetics, Molecular Biology, or related field
Strong background in Drosophila genetics, molecular biology, cell biology and/or neurobiology, biochemistry
Ability to think independently and work collaboratively

Link: https://hhmi-openhire.silkroad.com/epostings/index.cfm?fuseaction=app.dspjob&jobid=327
Employer: Howard Hughes Medical Institute (HHMI)
Principal investigator: Paul Taylor
Location: Memphis, TN
Sector: Academia
Degree required:
Conditions: ALS, FTD, NDG
Job posted: August 16th, 2016
Howard Hughes Medical Institute (HHMI)Memphis, TNALS, FTD, NDGAug 16, 2016
Research Specialist – Taylor Lab

Research Specialist – Taylor Lab

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Description: The Howard Hughes Medical Institute is seeking a highly motivated Research Specialist to join Dr. J. Paul Taylor’s group at St. Jude Children’s Research Hospital. The primary focus of this position will be the use of Drosophila melanogaster as a tool to investigate the molecular genetics of neurological diseases.

For more information about the work in Dr. Taylor's laboratory, please visit us at: http://www.hhmi.org/scientists/j-paul-taylor

Click on the link below to apply for this position. Please submit a cover letter and three letters of reference along with your resume/CV. No phone calls please.

Representative Essential Duties and Responsibilities:

To elucidate the pathogenic mechanisms underlying genetic forms of amyotrophic lateral sclerosis and related diseases using a wide range of approaches including molecular biology, genetics, biochemistry, behavior, and state of the art imaging.

Preferred Qualifications:

  • PhD in/or Neuroscience, Genetics ,Molecular Biology, or related field

  • Strong background in Drosophila genetics, molecular biology, cell biology and/or neurobiology, biochemistry

  • Ability to think independently and work collaboratively



Link: https://hhmi-openhire.silkroad.com/epostings/index.cfm?fuseaction=app.dspjob&jobid=326
Employer: Howard Hughes Medical Institute (HHMI)
Principal investigator: J. Paul Taylor
Location: Memphis, TN
Sector: Academia
Degree required:
Conditions: ALS, FTD, NDG
Job posted: August 16th, 2016
Howard Hughes Medical Institute (HHMI)Memphis, TNALS, FTD, NDGAug 16, 2016
Assistant Project Manager – NEALS

Assistant Project Manager – NEALS

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Description: The Neurological Clinical Research Institute (NCRI) develops, designs, supports and manages innovative observational and interventional trials for neurological disorders. This fast paced institute has an impressive record of efficiently organizing, overseeing, coordinating, and conducting small and large multi-center, international clinical trials. The mission of the NCRI is to accelerate translational research in neurological disorders through initiating and testing novel therapies. The NCRI also serves as a Coordinating Center for the Northeast ALS Consortium (NEALS), a non-profit, research consortium committed to the cooperative implementation, timely completion, analysis, and reporting of clinical trials and other research studies aimed at improving patient care and understanding of the disease process of Amyotrophic Lateral Sclerosis (ALS).

Receiving general direction from the Director of Research Operations and Co-Director of the Neurological Clinical Research Institute (NCRI), the Assistant Project Manager (APM) will assist Project Managers with all project management activities related to conducting multi-center clinical trials managed by the NCRI. Daily responsibilities will include generating reports for various committees, funding organizations, and regulatory offices, assisting in site initiation, study monitoring to insure compliance (travel may be required), and assist in and additional study related projects as they arise.


Project Management Responsibilities Include:

  • Develop protocols, including updates and amendments

  • Develop model consent forms and revisions

  • Prepare grant submissions

  • Create case report form documents

  • Obtain required documentation from study sites for the conduct of the studies, including biographical materials, other support, IRB approval letters, approved consent forms, and institutional support letters

  • Draft and oversee the production, distribution and updates of the operations manual, which includes the detailed guidelines for study implementation at the sites

  • Monitor enrolling site performance for subject accession and data acquisition in accordance with the protocol and conveying this information to the study principal investigator as needed

  • Assist the study Principal Investigator in implementing site monitoring plans

  • Oversee, with the study principal investigators, the development of the computerized database for each new study. to inspect data forms for legibility, completeness and ambiguity

  • Ensuring site compliance with all federal regulations and Good Clinical Practice Guidelines inspecting source documentation and CRFs to verify accuracy, legibility, and completeness  acquiring detailed knowledge of assigned studies follow all NCRI monitoring SOP guidelines for monitoring of clinical studies

  • Prepare budget reports and check requests for site payments, as needed

  • Monitor clinical sites, as needed, monitoring responsibilities include:

  • Travel to sites to review case report forms and regulatory documents;

  • Travel time will vary with phase of study; estimated travel is 20 to 80%

  • Document reportable events and other major concerns related to the studies and disseminating the information as needed to the PI, Medical Monitor and/or Steering Committee

  • Accept responsibilities for special projects, as requested

  • Review reports for publication and prepare reports for safety monitoring committee, as needed


General Administrative Duties Include:
Arrange the agendas and logistics of the annual training/review meetings of the investigators and coordinators, and for the meetings of the Steering and Safety Monitoring Committees, in concert with other meetings of the study investigators; Field site questions and provide protocol clarifications on a daily basis via telephone, fax, e-mail and surface mail

Qualifications
BA/BS Required; Good working knowledge of federal regulations and ICH/GCP Guidelines required; Good oral and written communication skills; Prior clinical trial and monitoring experience preferred; 1-2 years in a clinical research setting; Potential to grow into leadership position.



Link: https://partners.taleo.net/careersection/ex/jobdetail.ftl?job=3013590&src=JB-10326
Employer: Massachusetts General Hospital (MGH)
Location: Boston, MA
Sector: Academia
Degree required:
Conditions: ALS
Job posted: August 1st, 2016
Massachusetts General Hospital (MGH)Boston, MAALSAug 01, 2016
Faculty Position – Assistant Professor, Neuroinflammation Research

Faculty Position – Assistant Professor, Neuroinflammation Research

(Click title to open job details in a new window.)
Description:
St. Joseph's Hospital and Medical Center and the Barrow Neurological Institute® (BNI) have consistently been recognized for clinical and research excellence in an academic medical center setting and for the high quality of patient and employee experiences in the organizations.  Laboratory-based research and patient-oriented clinical studies have international stature and often involve extensive collaborations with academic and industry partners regionally, nationally and globally.  There are educational experiences at secondary school, undergraduate, graduate and post-graduate levels.  Administrative functions ensure that there is safe, ethical and responsible conduct of research and facilitate research management and interfaces with other units in the Hospital and Institute.  Opportunities exist to become part of this unique and dynamic enterprise.


The BARROW NEUROLOGICAL INSTITUTE seeks an exceptionally promising or accomplished investigator to study neuroinflammation and complement other translational neuroscience research in a unique and dynamic environment within the Division of Neurobiology at the Barrow Neurological Institute (https://www.barrowneuro.org/).


Qualified applicants holding Ph.D., M.D. or equivalent degrees will be considered for appointment at assistant, associate or full professor levels.  The successful candidate will be expected to use interdisciplinary approaches to direct an extramurally-funded research program in inflammatory related research associated with neurologic disorders. Institutional strategic interests for this position include Alzheimer’s disease, Multiple Sclerosis, Parkinson’s disease, amyotrophic lateral sclerosis, and brain injury.  Qualified applicants in other areas of translational neuroscience research also will be considered.  The successful candidate is expected to synergize/collaborate with existing research and clinical faculty, will have access to core facilities and clinical samples, and may leverage opportunities to collaborate with investigators at affiliate institutes including Phoenix Children’s Hospital, the Translational Genomics Research Institute, and the University of Arizona.


 

Link: http://www.dignityhealthcareers.org/careers/jobs/job.php?id=1600015459-assistant-professor-neuroinflammation-research
Employer: St. Joseph's Hospital and Med Ctr / Barrow Neurological Institute
Location: Phoenix, Arizona
Sector: Academia
Degree required:
Conditions: ALS, NDG
Job posted: August 1st, 2016
St. Joseph's Hospital and Med Ctr / Barrow Neurological InstitutePhoenix, ArizonaALS, NDGAug 01, 2016

Industry

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Director of Neurodegeneration Disease Models

Director of Neurodegeneration Disease Models

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Description: Alector is looking for exceptional scientists, senior scientists, and director-level investigators with a PhD and/or MD, an outstanding publication and track record, and a drive to innovate. The candidate must have extensive, hands-on expertise in conducting and managing disease model studies for neuro-degeneration and dementia, including Alzheimer’s disease, Parkinson’s disease, Frontotemporal dementia and ALS, in rodents. The successful candidates will play leading roles in the discovery and development of novel, disease-modifying drugs.

Requirements:
- Extensive first-hand experience in behavioral tests.
- Deep knowledge immunohistochemistry, FACS analysis, microscopy, IACUC protocols
- Experience with: Antibody therapeutics, primary cell cultures, immunology and/or neuro-immunology
- Management skills should include demonstrated hands-on ability to interact with a diverse research team and to develop, execute, and manage multiple in vivo programs, both in-house and through contract organizations.

Link: http://www.ventureloop.com/ventureloop/jobdetail.php?r=f_in&jobid=471925
Employer: Allector
Location: San Francisco, CA
Sector: Industry
Degree required:
Conditions: ALS, FTD, NDG
Job posted: September 20th, 2016
AllectorSan Francisco, CAALS, FTD, NDGSep 20, 2016
Senior Manager/Associate Director Pharmacometrician

Senior Manager/Associate Director Pharmacometrician

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Description: The Pharmacometrician is responsible for the construction, validation, and implementation of disease, placebo, exposure-response, and mechanistic PKPD models to evaluate risk/benefit and facilitate drug development decisions, in close collaboration with Clinical Pharmacologists and other R and D partners.

Essential Areas of Responsibility

  • Lead the design and execution of Model Based Drug Development strategy using quantitative approaches to address complex questions arising during drug development

  • Manage and perform pharmacometric analyses done internally and/or by external vendors using a variety of tools and approaches.

  • Proactively contribute expert input into key pre-clinical, clinical, and regulatory documents.

  • Ensure constructive collaboration within drug development teams and with other internal partners (e.g. DMPK, Regulatory Affairs, Clinical Development, and Biostatistics).

  • Monitor timelines, objectives and, budgets. Ensure accuracy of project and activity progress. Assure rapid and effective communication of high-quality data and results to project teams.

  • Act as technical subject matter expert in key clinical pharmacology / DMPK / pharmacometric related area.


 

REQUIREMENTS

  • PhD in Clinical Pharmacology, Pharmacokinetics, Pharmacometrics, Biostatistics, Biomedical Engineering

  • 5-10 years of industry experience in pharmacometrics in clinical pharmacology and/or clinical PK/PD.
    Experience in mechanistic PKPD modeling/systems pharmacology, meta-analyses, population modeling, and clinical trial simulations

  • Preferred: Experience in the following therapeutic area(s): neurodegeneration, movement disorders, pain



Link: https://jobs-tevapharm.icims.com/jobs/17607/senior-manager-associate-director-pharmacometrician/job?mode=job&iis=Indeed&iisn=Indeed.com&mobile=false&width=762&height=500&bga=true&needsRedirect=false&jan1offset=-480&jun1offset=-420
Employer: Teva Pharmaceuticals
Location: Frazer, PA
Sector: Industry
Degree required:
Conditions: NDG
Job posted: September 11th, 2016
Teva PharmaceuticalsFrazer, PANDGSep 11, 2016
Group Leader, Translational Biomarkers

Group Leader, Translational Biomarkers

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Description: Denali Therapeutics is seeking to recruit a Group Leader to lead the company’s translational biomarker efforts. S/he will be responsible for leading translational biomarker strategies and developing and implementing biomarker assays to assess the target engagement and PK/PD/response relationships of drug candidates in both preclinical models and clinical trials.

Responsibilities:
Lead the translational biomarker strategies for each program, incorporating the latest research findings and emerging technologies.
Oversee preclinical assay development, including both the establishment of in-house biomarker analytical capabilities and the management of outsourced assays and labs.
Develop and implement preclinical biomarker assays for drug candidates.
Assess emerging technologies and establish new technical platforms and assays to support biomarker research.
Write, edit, and review protocols and reports and contribute to regulatory documents.

Successful candidates will have many of the following qualities:
PhD with a minimum of 3-5 years of experience in the biotech/pharmaceutical industry.
Experience in translational research and in the discovery, characterization, and validation of drug candidates.
Experience with multiple assay platforms including flow cytometry, ELISA, qPCR, Western, RNAseq, and/or mass spec.
Experience in the validation and optimization of research assays for use in a clinical setting.
Record of high-level publications focused on neurobiology, biomarkers and/or translational models of disease.

Link: http://www.denalitherapeutics.com/careers/?gh_jid=254470
Employer: Denali
Location: South San Francisco, CA
Sector: Industry
Degree required:
Conditions: NDG
Job posted: September 3rd, 2016
DenaliSouth San Francisco, CANDGSep 03, 2016
Postdoctoral Position – Lewcock Lab

Postdoctoral Position – Lewcock Lab

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Description: Joe Lewcock’s Lab at Denali Therapeutics is seeking to recruit Postdoctoral Scientists to interrogate the molecular and cellular pathways underlying neurodegenerative diseases, with the ultimate goal of identifying new drug targets. Candidates should have proficiency in a broad range of molecular genetic, biochemical, and cellular techniques including: molecular cloning, transfection, RNA interference, Western blotting, immunofluorescence and/or live imaging techniques, and quantitative image analysis.

Requirements include:
Degree: Ph.D. in related field
Strong background in molecular neuroscience, cell biology, developmental biology, and/or neurodegeneration research
Expertise in the culture of mammalian cell lines, isolation and transfection of primary neurons from rodent brain is highly desired
Priority will be given to candidates with no or short (< 3 years) prior postdoctoral experience

Link: http://www.denalitherapeutics.com/careers/?gh_jid=269270
Employer: Denali
Location: South San Francisco, CA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: September 3rd, 2016
Denali South San Francisco, CAPhDNDGSep 03, 2016
Director, Neuropharmacology

Director, Neuropharmacology

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Description: The Neuropharmacology Research group is seeking independent and motivated scientists to join a newly established research team focused on the rapid progression of novel therapeutics to humans for neurodegenerative, neurobehavioral and neuromuscular diseases. The Director, Neuropharmacology will be responsible for establishing and leading a research pharmacology group responsible for developing and leading innovative approaches to the treatment of neurodegenerative, neurobehavioral and neuromuscular disorders. The candidate will be expected to lead their own research project, as well as oversee other drug development programs with the goal of building a robust and sustainable portfolio of candidates for clinical development. The candidate will also oversee the efforts and be responsible for guiding the career development of 6-10 scientists.

Management Responsibilities include:
1. Develop a neuropharmacology group that will establish and employ innovative approaches and technologies to identify and validate small molecule and protein therapeutics for neurodegenerative, neurobehavioral and neuromuscular disorders.
2. Scientific oversight and supervisory responsibility for PhD/MA/BA scientists with broad scientific backgrounds.
3. Establish aggressive but achievable goals that will support the overall goals of neuropharmacology research group.
General Qualifications
1. Provide strategic input into the identification and validation of novel targets for development on the Neurology discovery and development portfolio.
2. Provide technical and scientific direction to multi-disciplinary research teams.
3. Prepare, review and deliver scientific presentation for internal/external use.
4. External Thought Leadership:
a. Develop collaborative relationships with key opinion leaders.
b. Establish and maintain scientific eminence amongst the academic community by publishing and presenting research at internationally-recognized scientific conferences.
5. Review and contribute to scientific due diligence for in-licensing opportunities.

A candidate with a strong and established pharmacology background in interrogating mechanisms in vitro and vivo using genetics, small molecules and proteins. . Experience in establishing a linkage between human disease and developing biomarker strategies for integration and translation into clinical development plans is a must. Proven ability to deliver therapeutic candidates in the research to development pipeline space.

• Excellent communication skill and the ability and willingness to work effectively in a highly collaborative research environment.
• Ability to be a leader and deal with complex problems and propose creative solutions
• Ability to collaborate and work by influencing others in a matrixed environment
• Ability to be a self-starter and to identify and communicate priorities in the absence of complete information
• Ability to navigate through, but not avoid conflict
• Experience developing the careers of others

Education: PhD and/or MD with at least 10 years of post-doctorate training experience

Link: https://jobs.biogen.com/job/Cambridge-Director%2C-Neuropharmacology-MA-02138/315716600/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required:
Conditions: NDG
Job posted: August 25th, 2016
BiogenCambridge, MANDGAug 25, 2016
Scientist I, Research

Scientist I, Research

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Description: Perform Drosophila neurobiological research to study neuronal function including electrophysiology and imaging. Design and execute experiments that test disease biology and investigate neuronal function in genetic models of neurodegenerative disease in the fly. Conduct hands-on research and interact with other members of the Department of Neurology Research engaged in biomedical and behavioral studies. Perform research involving electrophysiological and imaging techniques in Drosophila.

Experience must include:
• Demonstrated background with electrophysiological and imaging techniques in Drosophila.
• Demonstrated record of independently designed and executed basic exploratory research projects.
• Basic knowledge of human disease pathways.
• Ability to work effectively in a highly collaborative research environment.
• Demonstrated ability to design and execute experiments that test disease biology and investigate neuronal function in genetic models of neurodegenerative disease in the fly.
• Technical proficiency in methods to culture human cell lines and perturb gene function using standard approaches.
• Ability to establish primary neuronal cultures from rodent brains.
• Demonstrated expertise with modern imaging technologies such as live imaging using Spinning disc confocal microscopy.
• Molecular biology (cloning) and biochemistry techniques including RT-PCR, western blotting, q-RT-PCR, plate-based quantitative PCR. Experience can be gained, before, during, or after advanced degree studies. 40 hours per week 9:00 a.m. to 5:00 p.m. Monday - Friday. Please submit resumes to: Patricia Bass, Global Mobility Coordinator, 27376BR. Biogen, Inc., 225 Binney Street, Building 1, Cambridge, MA 02142.

Requirements: Requires a Ph.D. (or foreign equivalent) in Neurobiology, Neuroscience, Cell Biology or a directly related field plus two (2) years of postdoctoral or industry experience in methods to study neural function including electrophysiology and imaging.

Link: https://jobs.biogen.com/job/Cambridge-Scientist-I%2C-Research-MA-02138/322025500/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required:
Conditions: NDG
Job posted: August 25th, 2016
BiogenCambridge, MANDGAug 25, 2016
Scientist I/II, Research

Scientist I/II, Research

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Description: The Biogen Epigenetics group seeks a highly motivated, creative scientist who will expand capabilities in epigenomic engineering within our Epigenetics and Cell & Gene Therapy groups, in consultation with colleagues in Neurology and Rare Disease groups. This scientist will have interests in the discovery and validation of mechanisms, pathways and potential drug targets for the treatment of neurodegenerative and rare diseases. S/he will create the means for the validation and modulation of targets of interest through the development of epigenomic engineering approaches for the modulation of disease-relevant target genes.

The ideal candidate will have an exemplary track record of scientific accomplishments, as reflected by a strong publication record, and will leverage evolving approaches in epigenetic research and epigenomic engineering to generate new opportunities for drug discovery. Experience in the investigation of epigenetic mechanisms and/or expertise in molecular and cell biology and an interest in epigenomic engineering are preferred. Research experience in epigenetic mechanisms underlying neurodegenerative and rare disease is highly desirable. Competitive candidates will be comfortable working in a fast-paced, dynamic, collaborative research environment, and will have a strong interest in translational research that will yield benefits to patients living with neurodegenerative and rare diseases.

Key Behaviors:
Engagement in hands-on bench work
Communication/influencing skills
Entrepreneurial spirit
Adaptable/flexible/agile
Creative/innovative/problem-solving
Education A Ph.D. in biochemistry, cell biology or a related discipline (background flexible), and 5+ years of postdoctoral/industrial experience

Link: https://jobs.biogen.com/job/Cambridge-Scientist-III%2C-Research-MA-02138/354319200/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required:
Conditions: NDG
Job posted: August 25th, 2016
BiogenCambridge, MANDGAug 25, 2016
Scientist II, NeuroImmunology

Scientist II, NeuroImmunology

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Description: The Neuroimmunology Research at Biogen is seeking a highly motivated scientist with a demonstrated track record of publications and presentations to drive independent basic exploratory research programs and lead cross-functional drug development team. The successful research scientist should possess a strong understanding of the mechanistic basis of neuroinflammation/neurodegeneration, as well as cutting edge knowledge on microglia and astrocyte biology, including familiarity with in vitro and in vivo models of neuroinflammation and neurodegenerative diseases. The scientist will be expected to apply a deep and broad knowledge of experimental neuroinflammation to creatively explore new biology and develop novel therapeutics. While prior drug development experience is preferred but not required, the candidate must have demonstrated the ability to work closely with research scientists in a team environment. Flawless oral and written communication skills are essential.

The successful candidate will be responsible for spearheading innovative research efforts aimed at better understating the role of neuroinflammation in neurodegeneration with the goal of developing novel therapies to treat neurodegenerative diseases such as Alzheimer’s , Parkinson’s and ALS. The candidate is expected to lead a small group of Associate Scientists to execute on his/her research projects, as well as collaborate on other target identification/validation projects and drug development programs within NeuroImmunology Department.

Responsibilities
Develop a creative and innovative research plan
Design and conduct key in vitro and in vivo experiments
Supervision of Associate Scientists
Prepare, review and deliver scientific presentations for internal/external use
Keep abreast of, and use, state-of-the-art technologies in drug discovery
Interact with key opinion leaders;
Establish and maintain collaborations with leading academic groups

Other skills
Ability to alternate between leading and being a team player
Ability to deal with complex problems and propose creative solutions
Ability to collaborate and work by influencing others in a matrixed environment

Link: https://jobs.biogen.com/job/Cambridge-Sr-Scientist%2C-NeuroImmunology-MA-02138/333875500/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD, MD
Conditions: NDG
Job posted: August 17th, 2016
BiogenCambridge, MAPhD, MDNDGAug 17, 2016
Computational Biologist

Computational Biologist

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Description: Verge Genomics is looking for a genomics scientist to develop algorithms, statistical methods, and software to analyze large-scale gene expression and genomic datasets. You will implement these methods to identify new disease targets and mechanisms, and drugs that target these disease gene networks. As one of the first employees at Verge, you will develop cutting-edge methods that will serve as the foundation of a revolutionary drug development model.

Responsibilities:

  1. Develop and implement methods for integrative analysis of microarray, RNA-sequencing, and GWAS data to identify gene networks involved in disease.

  2. Develop and implement novel pattern-matching methods for querying drug response databases with gene expression signatures.

  3. Integrate gene expression, behavioral, and biochemical datasets (and potentially patient EMR and prescription records), to predict which drugs are more likely to succeed in clinical trials

  4. Collaborate with internal and external research scientists in big pharma, small biotech, and patient advocacy organizations on analyzing genomic data for novel target discovery and drug development.


Requirements:

  1. Minimum of 2-5 years of doctoral, post-doctoral or professional experience analyzing or interpreting large-scale genomic/genetic datasets.

  2. Extensive experience with R development, preferably for genetics/genomics applications.

  3. Experience with differential expression and gene network analyses

  4. Excellent communication skills and ability to collaborate across the organization.

  5. Strong desire to work in a high-energy, hands-on startup environment.


Preferred:

  1. Prior experience with public repositories of genetic, genomic, and drug response data (ArrayExpress, GEO, CMAP).

  2. Prior project experience with experimental models of neurodegenerative disease.

  3. Prior experience with drug discovery and/or development.


Education: MS or PhD in statistics, bioinformatics, computational biology, computer science, statistical genetics, or a related field.

Location: Must be based in the San Francisco area to work in person. Relocation available.

Compensation: Compensation will be based on experience and include significant equity ownership. Full benefits & start-up perks provided.

Link: http://www.vergegenomics.com/careers
Employer: Verge Genomics
Location: San Francisco, CA
Sector: Industry
Degree required: PhD, MD, MD/PhD
Conditions: ALS, NDG
Job posted: August 16th, 2016
Verge GenomicsSan Francisco, CAPhD, MD, MD/PhDALS, NDGAug 16, 2016
Director, Neuroscience Research & Drug Discovery

Director, Neuroscience Research & Drug Discovery

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Description: Verge Genomics is seeking a motivated and highly accomplished “drug hunter,” responsible for directing, managing, and leading basic research and drug discovery efforts for neurodegenerative diseases and leading multidisciplinary project teams. This position offers the opportunity to grow and lead a drug discovery program at an emerging biotech from the ground up, while establishing important external partnerships. As a member of the early team at Verge, you will be deeply involved in key strategic decisions and in organization of the research & discovery team, and help build the foundation of a revolutionary drug development model.

Responsibilities:

  1. Play a key leadership role in expanding Verge’s drug discovery programs from inception to clinical candidate selection.

  2. Develop a neuroscience discovery group that will establish and employ innovative approaches to identify and validate small molecule therapeutics for neurodegeneration

  3. Work with an extensive network of CROs and academic partners for the design, analysis, and interpretation of key experimental data from target ID to clinical candidate selection. This will include helping establish the key assays by which novel biology and technology are created, and assist in transitioning these to specific pipeline drug candidates.

  4. Establish aggressive but achievable goals that will support the overall goals of neurodegenerative research group.

  5. Develop and maintain collaborative relationships with key opinion leaders and academic/industry partners.

  6. Mentor, train and direct PhD scientists in these efforts and assure their productivity

  7. Provide direction and vision to set the Neuroscience portfolio strategy and lead multidisciplinary scientific groups to drive compound specific discovery programs. Reports to the Chief Executive Officer.


Requirements:

  1. Ph.D. in Neuroscience, Physiology, Molecular Biology/Cell Biology or related fields

  2. Minimum 10 years of progressive industry experience in Neuroscience or Neuroscience-related areas, with significant contributions to the field as demonstrated by peer-reviewed publications and presentations at national or international meetings

  3. Track record of overseeing development of candidates from target identification through IND-enabling studies

  4. Strong record of basic or translational research on neurodegnerative disease, with broad experience across a wide variety of in vitroand in vivo methods in neuroscience discovery

  5. Significant experience and comfort working in an outsourced model of drug discovery, including experience establishing and managing collaborative alliances with CROs, industry partners, and academic institutions.

  6. Successful track record of leading large teams or multiple groups

  7. Proven ability to hire, coach and develop world class talent

  8. Excellent leadership capabilities with demonstrated skill in building, guiding and motivating effective teams and fostering productive research collaborations

  9. Outstanding communication skills and ability to collaborate across multidisciplinary scientific discovery settings.


Preferred:

  1. Strong and established pharmacology background in interrogating mechanisms in vitro and vivo using genetics, small molecules and proteins.

  2. Demonstrated contributions to R&D efforts that have led to the development of clinical candidates

  3. Experience in establishing a linkage between human disease and developing biomarker strategies for integration and translation into clinical development plans.

  4. Ability to be a self-starter and to identify and communicate priorities in the absence of complete information.


Education: Ph.D. in Neuroscience, Physiology, Molecular Biology/Cell Biology or related fields with minimum 10 years industry experience

Location: Must be based in the San Francisco area to work in person. Relocation available.

Compensation: Compensation will be based on experience and include significant equity ownership. Full benefits & start-up perks provided.

If interested, please submit a letter of interest and CV to careers@vergegenomics.com.

Link: http://www.vergegenomics.com/careers
Employer: Verge Genomics
Location: San Francisco, CA
Sector: Industry
Degree required: PhD, MD, MD/PhD
Conditions: ALS, NDG
Job posted: August 16th, 2016
Verge GenomicsSan Francisco, CAPhD, MD, MD/PhDALS, NDGAug 16, 2016
Senior Scientist, Neuroscience Research & Drug Discovery

Senior Scientist, Neuroscience Research & Drug Discovery

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Description: Verge Genomics is seeking a highly motivated individual to spearhead pre-clinical development of disease modifying treatments for neurodegenerative diseases. You will be responsible for advancing our current and emerging lead candidate pipeline through all stages of pre-clinical development, acting as a leader of multidisciplinary project teams. You will oversee important external collaborations with contract research organizations (CROs), leading academic groups, non-profits, and pharmaceutical partners. As one of the first employees at Verge, you will develop help build the foundation of a revolutionary drug development model.

Responsibilities:

  1. Manages and leads multiple projects evaluating efficacy of small molecules for treatment of Alzheimer’s Disease, ALS, and Parkinson’s Disease

  2. Identifies, engages, and manages external collaborations with CROS, leading academic groups, and patient advocacy organizations

  3. Generate and implement pre-clinical development plans with aggressive timelines that are well-designed, rigorous, and cost-efficient

  4. Maintain strong relationships with pharmaceutical partners and key opinion leaders, with emphasis on understanding their needs and adapting research strategy accordingly


Requirements:

  1. Minimum of 2-5 years of doctoral, post-doctoral or professional experience in Molecular Biology, Neuroscience, or other Life Science related field

  2. Experience with in vitro and in vivo models of Alzheimer’s Disease, ALS, and/or Parkinson’s Disease

  3. Experience establishing and managing research collaborations with CROs and academic institutions

  4. Excellent communication skills and ability to collaborate across multidisciplinary scientific discovery settings.

  5. Demonstrated organizational skills in managing multiple projects at a time


Preferred:

  1. Experience testing potential therapeutic molecules in biotech/pharmaceutical settings

  2. Familiarity with experimental endpoints ranging from histology to behavior

  3. Strong scientific background as evidenced by publications in high impact journals

  4. Familiarity with large-scale genomic and gene expression analyses


Education: MS or PhD in Molecular Biology, Neuroscience, Biochemistry, or other related life sciences field

Location: Must be based in the San Francisco area to work in person. Relocation available.

Compensation: Compensation will be based on experience and include significant equity ownership. Full benefits & start-up perks provided.

Link: http://www.vergegenomics.com/careers/#op-92208-senior-scientist-neuroscience-research--drug-discovery
Employer: Verge Genomics
Location: San Francisco, CA
Sector: Industry
Degree required: MSc, PhD
Conditions: ALS, NDG
Job posted: August 16th, 2016
Verge GenomicsSan Francisco, CAMSc, PhDALS, NDGAug 16, 2016
Principal Research Associate, Neuroscience

Principal Research Associate, Neuroscience

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Description: We are seeking a motivated Principal Research Associate to join a team of neuroscientists dedicated to developing novel therapies for diseases of the nervous system. The primary responsibility of this individual will be to validate new therapeutic targets for the treatment of amyotrophic lateral sclerosis (ALS) and additional CNS indications under consideration. The successful candidate will have experience with a variety of in vivo and in vitro experimental techniques.

Qualifications:
Basic Qualifications:
Requires a BS degree in neuroscience, biochemistry, or biology with 9 years of experience or an MS degree in neuroscience, biochemistry, or biology with 7 years of experience.
Preferred Qualifications:
Experience with animal handling, blood/tissue collection, compound administration/injection, perfusion, stereotaxic surgery, behavior testing, cell culture, immunohistochemistry, western blot analysis and molecular biology (DNA/RNA isolation, PCR, qRT-PCR, cloning) is desired. Good verbal, written communication and organizational skills are required.

Link: https://jobs.sanofi.us/job/-/-/507/2681234
Employer: Genzyme (Sanofi)
Location: Framingham, MA
Sector: Industry
Degree required:
Conditions: ALS
Job posted: August 1st, 2016
Genzyme (Sanofi)Framingham, MAALSAug 01, 2016

Non-Profit and Government

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Associate or Senior Editor

Associate or Senior Editor

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Description: Nature Communications is seeking a neuroscientist to join the editorial team of Nature Communications. Candidates with expertise in neurophysiology or neurodegeneration are particularly encouraged to apply. The successful candidate will handle original research papers, and work closely with other editors on all aspects of the editorial process, including manuscript selection and overseeing peer review. Editorial experience is not required, although applicants with significant editorial experience are encouraged to apply and will potentially be considered for Senior Editor positions.

Degree: A PhD (or equivalent) in a field of neuroscience. Some postdoctoral research experience is preferred.
Locations: Positions available at the following office locations: London; New York; Shanghai
Closing date: October 2, 2016

Link: https://career5.successfactors.eu/career?company=C0001215517P&career_job_req_id=12564&career_ns=job_listing&jobPipeline=Compliance_USDiversity
Employer: Springer Nature
Location: Multiple locations
Sector: Other
Degree required:
Conditions: NDG
Job posted: September 25th, 2016
Applications close: October 2nd, 2016
Springer NatureMultiple locationsNDGSep 25, 2016
Project Manager of Therapeutics

Project Manager of Therapeutics

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Description: California Institute for Regenerative Medicine (CIRM) is looking to hire a talented individual to join the Therapeutics Team as a Project Manager. The mission of the CIRM Therapeutics Team is to recruit and enable the development of innovative clinical stage regenerative medicine / cell therapy programs to address the unmet medical needs of patients. The Project Manager reports to the VP of Therapeutics and will coordinate operations of the Therapeutics Team in order to accomplish this mission. The Project Manager will manage the development and execution of project team strategy and will optimize the team’s effectiveness in achieving project objectives in alignment with the stated quarterly and annual goals of that team.

8 or more years multi-disciplinary experience in the medical or biotech/pharmaceutical industry with at least 4 years of direct project management in clinical research and/or drug development.  Strong proficiency with project management practices, technologies and methodology.  Financial acumen and experience with managing project budgets.  Demonstrate ability to translate strategy into action and to attain multi-stakeholder engagement.  Proven experience using Project Management software to manage complex project timelines and resources.

Advanced degree in science is desired (e.g. MS, PhD, MD, MBA) or commensurate experience.

Link: https://www.cirm.ca.gov/about-cirm/employment-opportunities
Employer: California Institute for Regenerative Medicine (CIRM)
Location: Oakland, CA
Sector: NON-PROFIT AND GOVERNMENT
Degree required:
Conditions:
Job posted: September 3rd, 2016
California Institute for Regenerative Medicine (CIRM)Oakland, CASep 03, 2016
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