Figure 3. Diffusion tensor imaging in the spinal cords of WT and cerebroside sulfotransferase knock-out (CST-KO) mice.
Image credit: Takano, et. al. 2012 under CC BY license

Job Opportunities

To submit any new job opportunities for this list, please email ALSjobs@prize4life.org. List the employer, location, closing date if applicable, and a link to more information. Jobs are removed after 3 months, unless requested otherwise.

This free job bulletin board aims to help scientists identify job opportunities in the field of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Positions described as broadly spanning neurodegenerative diseases (NDG) are noted as ‘NDG‘. The job listing includes research positions at all levels, as well as non-research positions for which a research background at the MS, PhD, or MD level is required.


Click the title of any table column to sort.

Academia

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Research Associate, ViTAL Consortium

Research Associate, ViTAL Consortium

(Click title to open job details in a new window.)
Description:

The postholder will join the ViTAL consortium of researchers working on Amyotrophic Lateral Sclerosis (ALS), funded by the charity TARGET-ALS. They will identify toxic elements that are secreted through exosomes in ALS, and determine their role in ALS. (Fixed-term until 30 June 2018)


We prefer to issue and receive applications via our on-line recruitment website at www.ulster.ac.uk/jobs


Hard copy applications can be obtained by telephoning 028 7012 4072


Link: http://www.nature.com/naturejobs/science/jobs/618061-research-associate-in-als-disease
Employer: University of Ulster
Location: Belfast, Ireland
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: June 26th, 2017
University of UlsterBelfast, IrelandBA or BSALSJun 26, 2017
NEW! Research Scientist

Research Scientist

(Click title to open job details in a new window.)
Description:

The Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco (UCSF) is seeking a molecular/cell biologist to design, develop and validate novel tools for the study of neurodegenerative diseases. The director of the IND is Nobel Laureate Dr. Stanley Prusiner.


The successful candidate will have a strong track record in neuroscience research and will join a multi-disciplinary team of scientists dedicated to finding a cure for neurodegenerative diseases by discovering small molecule drugs that prevent the propagation of misfolded proteins in cells, animal models, and eventually, human patients. The team is engaged in fundamental research to understand the process of protein misfolding as well as translational research to apply this knowledge toward drug discovery assays. The candidate should have strong practical experience in protein expression and cell culture. He or she should have excellent management and communication skills and work well in a team environment.


QUALIFICATIONS


Ph.D. with emphasis in neuroscience or neuropharmacology

At least 3 years of post-Ph.D. experience in both molecular and cell biology, including:

DNA cloning and the construction of expression vectors

Transfection and viral infection

Western blotting, immunoprecipitation and protein purification

Cell line differentiation

Stable transfection and cloning

Candidates with experience in cell-based assay development and/or cellular models of neurodegenerative diseases are strongly encouraged to apply

Applicants should possess excellent managerial, leadership, organizational, communication, and interpersonal skills, as well as exhibit evidence of imagination in problem solving.

Preference will be given to candidates with a demonstrated superb command of oral and written English.

This is a full-time position with excellent benefits. Salary is dependent upon experience. Rank will be commensurate with background, experience, and work history.


Interested applicants should submit curriculum vitae with a list of publications, a brief statement of research accomplishments and interests, and contact information for three professional references.


Please apply online at https://aprecruit.ucsf.edu/apply/JPF01324


Link: https://aprecruit.ucsf.edu/apply/JPF01324
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: June 23rd, 2017
University of CaliforniaSan Francisco, CAPhDNDGJun 23, 2017
NEW! Postdoctoral Fellow, Neurotherapeutics

Postdoctoral Fellow, Neurotherapeutics

(Click title to open job details in a new window.)
Description:

The research at the Division of Protein Technology is to a large extent focused on development of affinity proteins, including design and engineering of new functions and properties. Affinity protein development is a growing research discipline worldwide with applications in several fields such as biotech and medicine. The group of Biotherapy and Bacterial display has wide experience in combinatorial protein engineering of affinity proteins and has developed methods for such purposes exploiting both phage and bacteria.


The group is currently coordinating projects for development of new protein-based drug candidates targeting proteins and peptides involved in various neurological disorders, such as Frontotemporal Degeneration, Alzheimer’s and Parkinson’s diseases. For these projects, a post-doc position is open. The vacancy center on combinatorial protein engineering technologies, i.e. expression of large collections of protein variants on microorganisms and selection of candidates with desired properties from such collections. It will include exploiting and developing such technologies for generation and investigation of new protein-based reagents to generate affinity-based drug candidates. In line with KTH’s equal opportunity policy, we strongly encourage qualified female and minority candidates to apply.


Qualifications

The candidate should hold a PhD and an analytical/technical interest in molecular biotechnology and/or protein chemistry. Documented experience in protein engineering methodology, such as phage/yeast/bacterial display for generation of proteins with improved properties, is required. Theoretical knowledge of combinatorial protein engineering, including protein library design, is considered a distinct advantage. Experience with FACS, cell assays, recombinant protein production and purification (including affinity chromatography and HPLC) as well as biosensor assays (e.g. SPR-based), is also important.


Employment

Form of employment: Full-time and time-limited. One year, renewable one year.

Start date: As soon as possible

Salary: Salary follows the guidelines provided by KTH


Application

More information about how to apply can be found at https://www.kth.se/en/om/work-at-kth/lediga-jobb/what:job/jobID:158504/where:4/


Link: https://www.kth.se/en/om/work-at-kth/lediga-jobb/what:job/jobID:158504/where:4/
Employer: KTH Royal Institute of Technology
Location: Stockholm, Sweden
Sector: Academia
Degree required: PhD
Conditions: FTD
Job posted: June 22nd, 2017
Applications close: August 22nd, 2017
KTH Royal Institute of TechnologyStockholm, SwedenPhDFTDJun 22, 2017
NEW! Postdoctoral Fellow, Sareen Lab

Postdoctoral Fellow, Sareen Lab

(Click title to open job details in a new window.)
Description:

Dr, Dhruv Sareen’s independent research laboratory at the Cedars-Sinai Medical Center, Regenerative Medicine Institute focuses on using human iPSC technology to understand the molecular mechanisms underlying neurodevelopmental/degenerative diseases and how obesity is linked to the brain. His laboratory is particularly interested ‘disease-in-a-dish’ modeling for neuromuscular, neurodegenrative and motor neuron diseases including, amyotrophic lateral sclerosis (ALS). They are particularly interested in C9orF72 and other genetic forms of ALS and what are the common elements with sporadic forms of ALS. Using the iPSC platform his lab has developed novel methods for drug screening on patient motoneurons and dissecting mechanisms for motoneuron degeneration. In the context of stem cell modeling of neurodevelopmental (SMA) and neurodegenerative diseases (ALS) Dr. Sareen’s group is particularly interested in the mechanistic insights how specific neural cell types degenerate during the disease processes. They are using OMICS (proteome, transciptome, metabolome) and imaging methodologies to gain mechanistic insights into the mitochondrial and endorplasmic reticulum stress involvement. In addition, by understanding how the cells of the nervous system develop and differentiate we will be able to develop better and safer cells for transplantation and regenerative therapies. Dr. Sareen’s group has extensive experience in pluripotent and neural stem cell research. He has developed and directed a well-renowned human iPS cell core. He has published high-profile manuscripts on human iPSC-based disease modeling in SMA and ALS.


Dr. Sareen’s laboratory is searching for a highly-capable Post-doctoral Researcher to join his research group to investigate disease mechanisms in neurodegenerative diseases, especially motor neuron disorders. The incumbent should have experience in in neurobiology, biochemistry, molecular biology and stem cells, including analyzing their genetic and biochemical profiles by OMICS technologies. Bioinformatics (programming in R) knowledge is a plus. By using human iPS cell technology and differentiating into different brain cells as well as other tissues of the body we will investigate brain-linked disease mechanisms to develop assays in patient-derived enural cell types and screen for novel therapeutics. Working independently but in close cooperation and in consultation with the PI and other Research Scientists at RMI, the Post-doctoral Researcher will perform routine and complex laboratory procedures throughout. The Post-doctoral Researcher will be expected to assist the PI in preparation of multiple grant proposals and submission of such proposals. They will also prepare full manuscripts for publication as primary first and co-authors. The researcher will be expected to assist the PI in maintaining institutional IRB/SCRO protocols as well as develop new animal and IACUC protocols. The incumbent will develop, adapt, and implement new research techniques and protocols and will analyze and interpret data. They will participate in presentations as author or co-author on scientific meeting abstracts.

Under the direction of Dr. Sareen (PI) the incumbent will help us achieve our research goals by performing the principal duty of using pluripotent and neural stem cell culture techniques to generate neuronal and other tissue differentiation protocols, characterization of the differentiated cells (control vs disease) using techniques such as gene and protein expression, physiological, and phenotypic assessments. The candidate will also be expected to develop and perform differentiation protocols to direct pluripotent stem cells to endoderm, ectoderm and mesoderm lineages. The successful candidate will be responsible for all cell maintenance, expansion and genetic modification using viral vectors or other gene-editing methods. Therefore, experience in stem cell and neurobiology, knowledge of pluripotent/neural cell markers combined with a proven record in stem cell culture techniques is essential. Experience with bioinformatics analysis of RNA-seq and mass spec proteomics data are important. Prior experience in novel genome-editing technologies (CRISPR/Cas9) using pluripotent stem cells is a great asset. Prior experience in high-content compound screening/imaging techniques, handling of the Molecular Devices Image Express Micro system, and a Mass Spectrometer with data analysis are preferred traits. Proficiency in computer algorithm development for automating image-based analysis is also a desirable trait.


Link: https://www.cedars-sinaimedicalcenter.apply2jobs.com/ProfExt/index.cfm?fuseaction=mExternal.showJob&RID=26507&CurrentPage=33
Employer: Cedar Sinai Medical Center
Location: Los Angeles, CA
Sector: Academia
Degree required: MD, PhD, VMD, or DDS
Conditions: ALS
Job posted: June 22nd, 2017
Cedar Sinai Medical CenterLos Angeles, CAMD, PhD, VMD, or DDSALSJun 22, 2017
NEW! Research Associate

Research Associate

(Click title to open job details in a new window.)
Description:

Under the supervision of the Principal Investigator, the Staff Research Associate II (SRA II) will assist in the performance of behavioral testing and in the analysis of behavioral and neuroimaging data to support research on the neural bases of decision-making in healthy individuals with a family history of frontotemporal dementia. Specific techniques utilized in these studies will include online computer-based testing, task-based functional MRI, psychophysiology, voxel-based morphometry, functional connectivity, and computational modeling of behavior.


Responsibilities will include assistance in delivering online task-based behavioral assessments, in conducting behavioral/fMRI/psychophysiological testing with research subjects, performing image preprocessing and supervised analyses, managing and reporting on study results, overseeing study data integrity, and reporting study progress to the research team. The position represents an excellent opportunity to further develop research skills and learn basic principles of clinical and cognitive neuroscience.


Link: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?partnerid=6495&siteid=5226&jobId=2511562
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: BA or BS
Conditions: FTD
Job posted: June 22nd, 2017
University of CaliforniaSan Francisco, CABA or BSFTDJun 22, 2017
NEW! Graduate Studentship, Vande Velde Lab

Graduate Studentship, Vande Velde Lab

(Click title to open job details in a new window.)
Description:

Dr. Christine Vande Velde is looking to recruit a graduate student to her laboratory located at the CRCHUM facility, a research center affiliated with the Université de Montréal and located in Downtown Montreal.


Our lab is focused on understanding the molecular pathways that contribute to motor neuron degeneration in amyotrophic lateral sclerosis (ALS; also known as Lou Gehrig’s disease and Maladie de Charcot). Techniques include molecular biology, biochemistry, cell biology, and microscopy. We use both tissue culture and transgenic rodent models of disease. Projects include characterizing the role of TDP-43 in RNA granule dynamics, defining pathogenic mechanisms induced by misfolded SOD1, and exploration on hnRNP A1 in ALS biology. We are a young dynamic and bilingual team and we would like to add highly motivated individuals to the current crew. Salary will be based on institutional/CIHR guidelines.


Please submit your CV, your transcripts, and the names and contact information of three referees to c.vande.velde@umontreal.ca. Potential candidates will be contacted for an interview.


Selected Papers


K.K. McDonald, A. Aulas, L. Destroismaisons, S. Pickles, E. Beleac, W. Camu, G.A. Rouleau, and C. Vande Velde. (2011). TAR DNA-Binding Protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1. Human Molecular Genetics 20:1400-1410.


C. Vande Velde*, K.K. McDonald, Y. Boukhedimi, M. McAlonis-Downes, C.S. Lobsiger, S. Bel Hadj, A.N. Zandona, J.P. Julien, S.B. Shah and D.W. Cleveland*. (2011). Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset. PLoS One 6:e22031. *co-corresponding author.


S. Pickles and C. Vande Velde. (2012) Misfolded SOD1 and ALS: Zeroing in on mitochondria. Amyotrophic Lateral Sclerosis 13: 333-340. (invited review).


A. Aulas, S. Stabile and C. Vande Velde. (2012). Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP. Molecular Neurodegeneration 7:54.


S. Pickles, L. Destroismaisons, S.L. Peyrard, S. Cadot, R.H. Brown Jr, G.A. Rouleau, J.P. Julien, N. Arbour and C. Vande Velde. (2013). Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1. Human Molecular Genetics 22: 3947- 3959.


A. Aulas, G. Caron, C.G. Gkogkas, N.-V. Mohamed, L. Destroismaisons, N. Sonenberg, N. Leclerc, J.A. Parker, and C. Vande Velde. (2015). G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA. Journal of Cell Biology 209: 73-84.


Employer: CRCHUM
Principal investigator: Université de Montréal
Location: Montréal, Canada
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: June 20th, 2017
CRCHUMMontréal, CanadaBA or BSALSJun 20, 2017
NEW! Postdoctoral Fellow, Vande Velde Lab

Postdoctoral Fellow, Vande Velde Lab

(Click title to open job details in a new window.)
Description:

Dr. Christine Vande Velde is looking to recruit a PostDoc to her laboratory located at the CRCHUM facility, a research center affiliated with the Université de Montréal and located in Downtown Montreal.


Our lab is focused on understanding the molecular pathways that contribute to motor neuron degeneration in amyotrophic lateral sclerosis (ALS; also known as Lou Gehrig’s disease and Maladie de Charcot). Techniques include molecular biology, biochemistry, cell biology, and microscopy. We use both tissue culture and transgenic rodent models of disease. Projects include characterizing the role of TDP-43 in RNA granule dynamics, defining pathogenic mechanisms induced by misfolded SOD1, and exploration on hnRNP A1 in ALS biology. We are a young dynamic and bilingual team and we would like to add highly motivated individuals to the current crew. Salary will be based on institutional/CIHR guidelines.


Please submit your CV, your transcripts, and the names and contact information of three referees to c.vande.velde@umontreal.ca. Potential candidates will be contacted for an interview.


Selected Papers


K.K. McDonald, A. Aulas, L. Destroismaisons, S. Pickles, E. Beleac, W. Camu, G.A. Rouleau, and C. Vande Velde. (2011). TAR DNA-Binding Protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1. Human Molecular Genetics 20:1400-1410.


C. Vande Velde*, K.K. McDonald, Y. Boukhedimi, M. McAlonis-Downes, C.S. Lobsiger, S. Bel Hadj, A.N. Zandona, J.P. Julien, S.B. Shah and D.W. Cleveland*. (2011). Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset. PLoS One 6:e22031. *co-corresponding author.


S. Pickles and C. Vande Velde. (2012) Misfolded SOD1 and ALS: Zeroing in on mitochondria. Amyotrophic Lateral Sclerosis 13: 333-340. (invited review).


A. Aulas, S. Stabile and C. Vande Velde. (2012). Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP. Molecular Neurodegeneration 7:54.


S. Pickles, L. Destroismaisons, S.L. Peyrard, S. Cadot, R.H. Brown Jr, G.A. Rouleau, J.P. Julien, N. Arbour and C. Vande Velde. (2013). Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1. Human Molecular Genetics 22: 3947- 3959.


A. Aulas, G. Caron, C.G. Gkogkas, N.-V. Mohamed, L. Destroismaisons, N. Sonenberg, N. Leclerc, J.A. Parker, and C. Vande Velde. (2015). G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA. Journal of Cell Biology 209: 73-84.


Employer: CRCHUM
Principal investigator: Université de Montréal
Location: Montréal, Canada
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: June 20th, 2017
CRCHUMMontréal, CanadaPhDALSJun 20, 2017
NEW! Director of Neurodegenerative Research

Director of Neurodegenerative Research

(Click title to open job details in a new window.)
Description:

We are currently on the hunt for a Director of Research– Neurodegenerative to oversee all aspects of neurodegenerative gene therapy research at the GTP at PENN. In this role, you will be responsible for build a team of Senior Research Investigators (SRI) to support GTP’s Neurodegenerative research efforts; establishing processes for mentoring and leading SRIs in research projects; directly oversee and manage a team of SRIs and technicians; In consultation with the PI of the GTP, the Research Director – Neurodegenerative will assess the rare disease programs that are brought into GTP for scientific research. The individual should have in-vivo pharmacology expertise for preclinical translational programs as well as expertise in testing the efficacy of therapeutic interventions for neurodegenerative disease indications. Joining GTP offers scientific professionals the unique opportunity of seeing their research go from bench to bedside and discoveries that could one day lead to cures.


As a top candidate for this role, you will possess:


Master’s Degree and 5 years to 7 years of experience or equivalent combination of education and experience required. Ph.D. strongly preferred.

Extensive knowledge of life science research in both academic and biopharmaceutical settings

Self-starter but also a strong desire to contribute and work collaboratively to achieve goals

Success in roles requiring execution of multiple tasks while responding to multiple priorities

Highly functioning, detail-oriented, and analytical candidate who can think strategically

Excellent oral/written communication skills required


Link: https://www.linkedin.com/jobs/view/333064453/
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: June 19th, 2017
University of PennsylvaniaPhiladelphia, PAPhDNDGJun 19, 2017
NEW! Director, Institute of Biotechnology

Director, Institute of Biotechnology

(Click title to open job details in a new window.)
Description:

Helsinki Institute of Life Science HiLIFE of the University of Helsinki is seeking a Director of the Institute of Biotechnology (bi.helsinki.fi). The Institute of Biotechnology (BI) is at the forefront of molecular biology research with eight current ERC grantees, and has a strong focus in biotechnology through developing new strategies e.g. to combat neurodegenerative and metabolic diseases. Current research programs at the BI are in Cell and Molecular Biology, Developmental Biology, Genome Biology, and Structural Biology and Biophysics. BI is an international, competitive and rewarding workplace, where the staff within the 25 research groups and 7 core facilities exceeds 250 and comes from 30 different countries. As of 2017 the Institute of Biotechnology is a unit of HiLIFE (www.helsinki.fi/hilife) and collaborates locally across life science units and organizations.


Expectations and conditions

Qualified candidates will be visionary scientific leaders of international stature and with a strong track record of innovative research in relevant areas, and with merits in building interdisciplinary academic research in a highly collaborative environment.


The Institute of Biotechnology Director will

• Be responsible for development of the institute, including producing and implementing a vision for future scientific growth as well as the recruitment of a new generation of outstanding and highly interactive researchers

• Lead her/his own research group

• Foster new collaborations including ones at the University of Helsinki and HiLIFE


The anticipated start date is January 2018 or earlier. The position is initially for five years with a possibility of renewal, and associated with funding for the group and a startup package when appropriate. The salary is negotiable within the salary system of Finnish universities.


Qualifications and experience

The successful candidate will

• Hold an appropriate doctoral degree

• Have an outstanding record of scientific discoveries and success in obtaining funding

• Present a clear vision of future directions in relevant research areas

• Demonstrate successful leadership of international and diverse teams

• Show a commitment to fostering excellence in scientific research and research training


Application deadline, inquiries and nominations

Applications are welcome until August 14, 2017. For further information or proposals for nominations please contact HiLIFE Director Tomi Mäkelä by email hilife-recruit@helsinki.fi or by phone +358 2941 25500.


Submission of applications

Applications are submitted to hilife-recruit@helsinki.fi as a single pdf file with

i) your vision for the development of the Institute of Biotechnology;

ii) your research plan (max 5 pages);

iii) your CV (max 4 pages including biosketch);

iv) a list of not more than 10 selected publications with motivation for selecting each;

v) a link or reference (e.g. ORCID) to a complete list of publications.


Link: http://www.nature.com/naturejobs/science/jobs/617619-director-of-the-institute-of-biotechnology
Employer: University of Helsinki
Location: Helsinki, Finland
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: June 17th, 2017
University of HelsinkiHelsinki, FinlandPhDNDGJun 17, 2017
NEW! Computational Chemist

Computational Chemist

(Click title to open job details in a new window.)
Description:

The Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco (UCSF) is seeking a computational/theoretical chemist to join the IND’s drug discovery programs in Alzheimer’s disease, frontotemporal dementia, Parkinson’s disease, Creutzfeldt-Jakob disease and others. The director of the IND is Nobel Laureate Dr. Stanley Prusiner.


The successful candidate will work with the drug discovery team as a computational chemist to identify and validate cellular high-throughput screening hits. For molecules in the lead optimization phase, the candidate should be able to influence and accelerate creative molecular design using modern computational tools and approaches.


He or she will possess an expert-level understanding of medicinal chemistry principles, including the optimization of properties favorable for a CNS therapeutic. He or she is expected to work closely with medicinal chemists at the IND and with our drug discovery partners at Daiichi Sankyo. The candidate should have excellent communication skills and work well in a team environment.


QUALIFICATIONS


• PhD in Chemistry with experience in the design of small molecule drug candidates.

• A strong track record of creative problem solving and scientific achievement

• A high level of expertise with quantum mechanical and other computational techniques to understand the conformational and stereoelectronic properties of small molecules

• A strong interest in conformational analysis and the ability to provide examples of how insights into conformation can lead to improved biological activity

• Proficiency with force field-based molecular dynamics methods to study the role of structure and conformational mobility of proteins for the purpose of drug design

• An understanding of the physical chemistry of ligand design and binding thermodynamics with experience docking small molecules with associated proteins

• Applicants should possess excellent leadership, organizational, communication and interpersonal skills

• Preference will be given to candidates with a demonstrated superb command of oral and written English


This is a full-time position with excellent benefits. Salary is dependent upon experience.


Interested applicants should submit curriculum vitae with a list of publications, cover letter, a research summary (4-page max. including figures), and contact information for three professional references.

Please apply online at https://aprecruit.ucsf.edu/apply/JPF01488


Link: https://aprecruit.ucsf.edu/apply/JPF01488
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: PhD
Conditions: FTD
Job posted: June 15th, 2017
Applications close: July 15th, 2017
University of CaliforniaSan Francisco, CAPhDFTDJun 15, 2017
Research Assistant, Neurodegenerative Disease

Research Assistant, Neurodegenerative Disease

(Click title to open job details in a new window.)
Description:

As a research assistant, the successful candidate will work with protein analysis (Western blot), histological analysis (immunofluorescence, in situ hybridization), analysis of data from in vivo neurotransmitter recordings (glutamate, dopamine recordings) and cytological analysis (immunofluorescence). The source of these samples will be from cell lines, animal models and human samples. The applicant will work close with patients and perform skin biopsies, blood sampling and lumbar punctures to obtain working material. The applicant will be responsible for analyzing these samples according to their respective protocols and the analyses are documented and stored in structured and easy to follow way.


The applicant will be expected to work well independently and as part of a team, establishing and maintaining collaborations. They should be motivated to work in an international and multidisciplinary research group. The applicant must also be able to perform interventions on patients as for the position is required to take patients samples as indicated above. Moreover, part of the job will be the access to the patients data sheets and categorize the samples regarding to the medical history of the patients.


Entry Requirements


The applicant must have an academic degree in the field of Medicine as she/he will need to have access to patient data and make medical interventions. A strong background in molecular and cellular imaging, preferably in the neuroscience field, is advantageous. Applicants may have spent part of their education in a foreign country, bringing international experience and a strong team spirit to the laboratory. Excellent command of the English language is highly preferred. It is also important that the applicant has clinical experience, for example taking skin biopsies, blood and biological fluid samples.


Link: https://ki.mynetworkglobal.com/se/what:job/jobID:152108/type:job/where:4/apply:1
Employer: Karolinska Institutet
Location: Stockholm, Sweden
Sector: Academia
Degree required: A university medical degree
Conditions: NDG
Job posted: June 14th, 2017
Karolinska InstitutetStockholm, SwedenA university medical degreeNDGJun 14, 2017
Lab Manager, Neurosciences Clinical Research Unit

Lab Manager, Neurosciences Clinical Research Unit

(Click title to open job details in a new window.)
Description:

The position is responsible for, and critically important to Neurosciences Clinical Research Unit (NCRU), and Memory and Aging Center (MAC) investigators for the overall operational management of clinical research activities for the biospecimens processing lab. The Lab Manager has direct responsibility for implementing a diverse portfolio of processing protocols which include multicenter clinical trials (both NIH and industry-sponsored), local investigator-initiated clinical trials, and clinical research activities, including a clinical database and biorepository LIMS system.


Required Qualifications

• BA/BS degree with a major in a related science and two or more years of recent, directly related work experience following degree completion, utilizing the techniques or methods required by the position and demonstrating technical expertise in these areas; or an equivalent combination of education and experience

• Knowledge of basic lab equipment

• Experience with sample processing

• Ability to handle data and samples meticulously, in a well-organized manner, with understanding of Good Documentation Practices

• Demonstrated ability to work under time pressure with attention to detail


Link: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?partnerid=6495&siteid=5226&jobId=2503229
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: BA or BS
Conditions: FTD
Job posted: June 9th, 2017
University of CaliforniaSan Francisco, CABA or BSFTDJun 09, 2017
Neuropathologist

Neuropathologist

(Click title to open job details in a new window.)
Description:

The Department of Pathology and Laboratory Medicine at the University of California (UC) Davis, School of Medicine is seeking a dynamic academic physician-investigator to provide clinical service and teaching in neuropathology, and who can develop an independent hypothesis-based research program in an area of neuroscience, such as Alzheimer’s disease or other neurodegenerative conditions, autism/neurodevelopmental disorders, neoplastic neuropathology. The expectation is that the candidate will spend approximately 30-50% clinical service and teaching and 50-70% research. Clinical duties will focus on surgical and autopsy neuropathology, though other subspecialty areas of anatomic pathology could be also considered based on the candidate’s training and interests. Teaching duties may include clinical, didactic, laboratory and small group teaching of housestaff, medical students, graduate students, and students in other health professional programs, and participation in interdisciplinary clinical conferences.


The successful candidate will have the opportunity to build on the many neuroscience strengths in the department, UC Davis Health System and UC Davis campus, including an established program in neuropathology, strong collaborative relationships with the Alzheimer Disease Center, MIND Institute, the Institute for Regenerative Medicines, Comprehensive Cancer Center, and the campus’ Center for Neuroscience, Center for Comparative Medicine, School of Veterinary Medicine, the California National Primate Center, and more.


Requirements include MD or MD/PhD, board-eligible or certified in anatomic pathology and neuropathology, and have an appropriate record of accomplishment in clinical service, teaching and research to meet requirements for appointment at the Assistant, Associate Professor level ( 50% Tenure Track / 50% In Residence). Eligibility for licensure to practice medicine in California is required. Other required skills include the ability to work cooperatively and collegially within a diverse environment, and the ability to build and maintain productive professional relationships with medical and technical staff, trainees, and others.


For full consideration, applications must be received by January 31, 2018; however, we will have our first review of applicants September 30, 2017. Position will be open until filled, but no later than June 30, 2018. Please forward the following: (1) Curriculum Vitae; (2) Cover letter; (3) Statement of clinical, teaching and research background; (3) List of names and contact information for at least five references to: http://apptrkr.com/1016588


Link: http://jobs.sciencecareers.org/job/452156/academic-neuropathologist/
Employer: University of California
Location: Davis, California
Sector: Academia
Degree required: MD or MD/PhD
Conditions: NDG
Job posted: June 8th, 2017
Applications close: January 31st, 2018
University of CaliforniaDavis, CaliforniaMD or MD/PhDNDGJun 08, 2017
Research Scientist, Neuroinflammation

Research Scientist, Neuroinflammation

(Click title to open job details in a new window.)
Description:

The Krembil Research Institute at the University Health Network in Toronto Canada is seeking an early to mid career basic scientist in the area of neuroinflammation. Preference will be given to individuals with a research focus on the involvement of innate immunity, including the roles of immune mediators such as microglia and astrocytes, and their expressed cytokines and chemokines, in neurodegenerative diseases affecting the human CNS. The successful candidate will have a PhD or MD/PhD, postdoctoral experience and demonstrated research excellence. The successful candidate will be expected to qualify for an appointment at the Assistant or Associate Professor level (status only) in the appropriate department at the University of Toronto.


The Krembil is one the principal research institutes of the University Health Network of academic teaching hospitals associated with the University of Toronto; the Krembil is also one of the largest research institutes in Canada focusing on human neurological disease from both a basic science and clinical research perspective. The University Health Network (UHN) is Canada’s largest academic medical centre, comprising four major teaching hospitals.



Qualifications


• Ph.D. in specialized discipline or advanced degree and 5 years closely related experience

OR

• Combination of education, experience and demonstrated ability that is recognized as equivalent

• Demonstrative ability to engage and work collaborative with all levels and members of the inter-professional team, research team and external stakeholders

• Demonstrated effective communication (written and verbal), problem-solving and

consensus-building skills


Qualified applicants are invited to submit their application (letter of interest, research plan, curriculum vitae) in PDF format. You will also be required to complete some initial screening questions. The search committee will begin to review applications in September with a potential start date in Winter 2018.


Link: http://jobs.sciencecareers.org/job/452043/scientist-in-neuroinflammation/
Employer: Krembil Research Institute
Location: Toronto, Canada
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: June 8th, 2017
Krembil Research InstituteToronto, CanadaPhDNDGJun 08, 2017
Assistant Professor, Psychiatry

Assistant Professor, Psychiatry

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Description:

The University of California, Irvine is recruiting an Assistant Professor for its growing Department of Psychiatry and new Sleep center. The successful candidate will be an outstanding researcher in sleep neuroscience, in particular, quantitative EEG and neuroimaging approaches to understanding neurodegenerative diseases such as Alzheimer’s disease, and the relationship between sleep and cognitive function. This is a Professor Series (academic senate) tenure-line appointment. Salary will be commensurate with training and experience. UC Irvine, located in Orange County, with a population of more than three million, has a long and distinguished tradition of excellence in neuroscience.


Requirements – Research-related experience in sleep, EEG analysis, neurodegenerative diseases and/or functional imaging desirable. Successful candidates must have a Ph.D. and/or a M.D. degree and a record of high-quality research, with scholarly activity and publications commensurate with experience. Candidates with extramural funding or submitted applications for mentored or independent awards, particularly from the federal government, are especially sought. It is expected that the successful candidate will develop an extramurally funded research program.


For further information and correspondence, please contact:

Ruth M. Benca, M.D. – Ph.D.

Professor and Chair

Department of Psychiatry and Human Behavior

Bldg. 3, Room 367

Orange, CA 92868


TO APPLY: Please log onto UCI RECRUIT located at: https://recruit.ap.uci.edu/apply/JPF03986


Applicants should complete an online application profile and upload the following application materials electronically to be considered for the position:


Cover letter

Curriculum vitae

Statement of Research—Please include a description of current research and future plans.

Three references with contact information

Diversity Statement


Link: https://recruit.ap.uci.edu/apply/JPF03986
Employer: University of California
Location: Irvine, CA
Sector: Academia
Degree required: PhD and/or MD
Conditions: NDG
Job posted: June 6th, 2017
Applications close: July 31st, 2017
University of CaliforniaIrvine, CAPhD and/or MDNDGJun 06, 2017
Senior Research Investigator

Senior Research Investigator

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Description:

This is an exciting and challenging position which will play a lead role in establishing a new research group at MRC Harwell, as part of a new collaborative programme between MRC Harwell and UCL Institute of Neurology to study neurodegeneration. This will involve making straight-forward gene targeted models for studying neurodegeneration, and also entirely novel genomic knock ins. You should have some hands on experience of genomic cloning and/or homologous recombination and will be able to learn novel technologies including CRISPR/Cas9 to produce new models for studying specific questions in neurodegenerative disease research. This is a pivotal post, as you will liaise with a group of neuroscientists to create the best models for tackling specific questions in neurodegeneration. You will supervise a team that includes a junior postdoc and two skilled laboratory technicians, providing them with support for their career progression.

For further information please visit our website – https://www.har.mrc.ac.uk/about/mammalian-genetics-unit


About You

You will be skilled in the areas of gene targeting/genome engineering/gene editing in the mouse, with peer-reviewed publications. You must have a PhD in an appropriate discipline (e.g. Genetics, Cell Biology) and a proven track-record in carrying out scientific research to an international standard. You must also demonstrate the ability to work in a multi-disciplinary collaboration, being able to communicate with colleagues working in a different location.


For full details of this post and to complete an online application, visit https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/609 and upload your CV along with a covering letter stating why you are applying for this role. Please quote reference number MGU 562.


Closing date: 3rd July 2017


Link: https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/609
Employer: MRC Harwell
Location: Harwell, England
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: June 6th, 2017
Applications close: July 3rd, 2017
MRC HarwellHarwell, EnglandPhDNDGJun 06, 2017
Postdoctoral Fellow, Gao Lab

Postdoctoral Fellow, Gao Lab

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Description:

A postdoctoral position is immediately available in the laboratory of Dr. Fen-Biao Gao at the University of Massachusetts Medical School to study molecular pathogenic mechanisms of fronototemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).


PhD required. Candidates with strong research experience in stem cell biology or molecular and cellular biology are encouraged to apply. Two years’ experience with cell culture (primary and cell lines), stem cell/neuronal differentiation preferred.


To Apply: Please forward CV to: Fen-Biao.Gao@umassmed.edu.


Link: http://www.nature.com/naturejobs/science/jobs/605061-postdoctoral-position
Employer: University of Massachusetts Medical School
Location: Worcester, MA
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: June 5th, 2017
Applications close: August 4th, 2017
University of Massachusetts Medical SchoolWorcester, MAPhDALS, FTDJun 05, 2017
Postdoctoral Fellow, Van Den Bosch Lab

Postdoctoral Fellow, Van Den Bosch Lab

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Description:

The research project, under supervision of principal investigator Ludo Van Den Bosch, will focus on the role of low complexity domains in disease-causing proteins, with a special focus on the dipeptide repeat proteins (DPRs) encoded from the hexanucleotide repeats in C9orf72. Effects of these DPRs on the nucleocytoplasmic transport and stress granule formation will be investigated. Biophysical techniques will be used to study the structural characteristics and dynamics of these structures. Moreover, this research will involve in vitro techniques including work with iPSCs, as well as in vivo research using small animal models (Drosophila and zebrafish).


Profile


​We are looking for a highly motivated postdoctoral researcher with interest in neurodegeneration and experience in. Motivated candidates with a strong commitment to basic research are invited to apply.


The candidate:


should hold a PhD degree in biology, biochemistry or biomedical sciences

should have experience in research on neurodegenerative disorders

should be able to work in a team with a high degree of autonomy

should be able to guide and supervise PhD students

should fluently speak and write English.


We offer a fulltime 3 year contract for a postdoctoral position in an enthusiastic and motivated team and a dynamic scientific work environment. The Center for Brain & Disease (CBD) at KU Leuven is an international research group focusing on neuroscience. The CBD provides different opportunities to present and share data on weekly seminars, lectures and international conferences. Different state-of-the-art core facilities are available for all CBD researchers.


For additional information concerning this job offer, please contact Lien Houbrechts (lien.houbrechts@kuleuven.vib.be)


How to apply?


http://www.vib.be/en/jobs/Pages/Postdoctoral-Researcher-Investigating-the-Role-of-Phase-Transitions-and-Stress-Granule-Dynamics-in-Neurodegeneration.aspx


Link: http://www.vib.be/en/jobs/Pages/Postdoctoral-Researcher-Investigating-the-Role-of-Phase-Transitions-and-Stress-Granule-Dynamics-in-Neurodegeneration.aspx
Employer: VIB
Location: Leuven, Belgium
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: June 1st, 2017
Applications close: July 31st, 2017
VIBLeuven, BelgiumPhDALS, FTDJun 01, 2017
Research Specialist, Plotkin Lab

Research Specialist, Plotkin Lab

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Description:

A full-time position is available in the lab of Alice Chen-Plotkin in the Department of Neurology at the University of Pennsylvania. Our lab researches neurodegenerative disease, with a particular focus on frontotemporal dementia and Parkinson’s disease. Projects range from studying the basic mechanisms of disease to finding and developing clinically useful tools such as biomarkers. Responsibilities for this position will include assistance with biochemical, molecular biological, and cell biological assays as needed to meet scientific goals. In addition, familiarity with analysis of large genetic datasets is preferred, including knowledge of statistical and computational methods (i.e. familiarity with linear/logistic regression, ability to use R or other statistical tools). All members of the lab are also expected to attend weekly lab meetings and to participate in the educational activities (e.g. journal club) of the lab.


Internal Number: 28742


Link: http://www.cellbiologyjobs.org/jobs/9115682/research-specialist-a
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: BS
Conditions: FTD
Job posted: June 1st, 2017
University of PennsylvaniaPhiladelphia, PABSFTDJun 01, 2017
Postdoctoral Fellow, Mueller Lab

Postdoctoral Fellow, Mueller Lab

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Description:

Responsible for advancing the lab’s preclinical programs for CNS diseases. Lead indications are SOD1, C9orf72-linked amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). Projects will include early stage research on genome editing for ALS, an IND-enabling study in non-human primates for a gene therapy candidate for ALS, and an IND-enabling study in non-human primates for a gene therapy candidate for HD.


Required Qualifications:


Applicants should have a PhD in biomedical sciences with a strong background in molecular biology and biochemistry, as well a track record in the field of ALS/CNS disorders (CNS Lead role) or liver diseases (Liver Lead role). Hands-on experience with relevant mouse models as well as excellent knowledge of CRISPR-based genome editing are required. Ability to work independently in a fast-paced research environment and multitask, be highly organized and adaptable are required. Strong writing, verbal and interpersonal skills are required.


Required skills:


• PhD degree in biomedical sciences

• track record in ALS/CNS disorders or liver diseases with at least two first author publications

• hands-on experience with genetic mouse models (CNS or liver)

• excellent knowledge of CRISPR-based gene editing

• excellent communicationj skills both oral and written are essential


Preferred skills:

• hands-on experience with CRISPR-based gene editing

• experience in next generation sequencing and bioinformatics

• experience in tissue culture, cytokine multiplex assays and ELISA


Additional Information:


Our lab is multicultural and supports personal development and work-life balance. Attractive salary and benefits available based upon relative working experience.


Worcester is located an hour away from Boston and offers a good quality of life with plenty or nearby outdoor activities and many restaurants.


Interested candidates please email CV to: Chris.Mueller@umassmed.edu


Apply Here: https://careers-umms.icims.com/jobs/28102/post-doctoral-associate-/login


Link: https://careers-umms.icims.com/jobs/28102/post-doctoral-associate-/login
Employer: University of Massachusetts Medical Center
Location: Worcester, MA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: May 31st, 2017
Applications close: July 29th, 2017
University of Massachusetts Medical CenterWorcester, MAPhDALSMay 31, 2017
Chair, Department of Neuroscience

Chair, Department of Neuroscience

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Description:

The UConn School of Medicine is seeking an outstanding neuroscientist at a rank of Associate or Full Professor to become Chair of the Department of Neuroscience. Candidates with nationally recognized accomplishments in research, sustained NIH or extramural funding, and leadership experience are encouraged to apply. Desired areas of expertise include but are not limited to cellular and molecular neuroscience, chronic and neurodegenerative diseases, brain circuitry research, and neurogenesis and regeneration. This position is ideal for an energetic individual with the leadership skills and vision required to foster the health and growth of a department that values academic excellence and collaboration. The departmental faculty excel in a variety of research areas

(neuroscience.uchc.edu), lead educational programs in the graduate, medical and dental schools, and provide a stimulating environment for research trainees.


Interested applicants should submit a cover letter indicating research interests, vision for the department and description of leadership style (maximum of 2 pages) with an up to date curriculum vitae in a single pdf file to the UConn Health Employment Services website (Search no. 2017-707)

https://jobs.uchc.edu. Please address questions to the search committee chair, Dr. Anthony Vella c/o Shelly Lombardo (neurosciencechair@uchc.edu). Applications will be accepted and reviewed until the position is filled.


Link: https://www.linkedin.com/jobs/view/355117116/
Employer: University of Connecticut School of Medicine
Location: Farmington, CT
Sector: Academia
Degree required: PhD or MD/PhD
Conditions: NDG
Job posted: May 28th, 2017
University of Connecticut School of MedicineFarmington, CTPhD or MD/PhDNDGMay 28, 2017
Lab Technician, Grinberg Lab

Lab Technician, Grinberg Lab

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Description:

The position is for a part time Lab Technician / Staff Research Associate I (SRA I) to assist the Principal Investigator (PI) in neuropathology research that investigates the pathogenesis of Alzheimer’s disease, frontotemporal dementia, and related disorders at UCSF Mission bay campus ( see http://grinberglab.ucsf.edu). The candidate is expected to be open to learning new methods.

The SRA I represents an excellent opportunity to further basic laboratory and research skills in a dynamic clinical neuroscience environment. The successful applicant will be an energetic, team player, self-directed learner with a keen interest in research.


Link: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?partnerid=6495&siteid=5226&jobId=2497141
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: BA/BS
Conditions: FTD
Job posted: May 26th, 2017
University of CaliforniaSan Francisco, CABA/BSFTDMay 26, 2017
Senior Research Investigator

Senior Research Investigator

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Description:

The Gene Therapy Program (GTP) and Orphan Disease Center (ODC) are entering a new era of unprecedented opportunity with great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases. Our R&D organization has a translational infrastructure that includes: technology discovery, specialized immunology assays operating under GLP, a Vector Core/Manufacturing unit that conducts GMP comparable work, and a large non-clinical program for animal testing under GLP including large NHP and rodent vivaria.


We are currently looking for Senior Research Investigator (SRI), Translational Research, to work in one of several therapeutic areas such as motor neuron, neurodegenerative, and/or therapeutic antibodies.

As a SRI, Translational Research, you will be involved in translation research projects in one or more therapeutic areas. In each case, you will be working in the setting of large interdisciplinary teams, where you will function independently in the execution of the experiments but will need to work collaboratively with other team members. Working independently, you will perform design, optimization and implementation of complex in vitro and in vivo experiments in rodents and NHP within specified timelines; provide cross-organizational support for the essential laboratory functions, including effective management of laboratory resources, and participation in maintenance of centralized reagents; contribute to writing/reviewing manuscripts, preparing presentations, establishing collaborations as well as writing/reviewing protocols and SOPs.


This position offers the opportunity to interface broadly internally & externally with diverse functional areas. Joining GTP offers scientific professionals the unique opportunity of seeing their research go from bench to bedside and discoveries that could one day lead to cures.

As a top candidate for this role, you will possess: Minimum of 5 years of experience after the completion of the PhD degree in the field of molecular biology, virology,biochemistry, enzymology, gene therapy, protein engineering, or related fields required.


Candidate must thrive in a team environment, have excellent written and oral communication skills, ability to prioritize in a fast-paced environment, and proficiency with standard methods of data analyses


Link: https://www.linkedin.com/jobs/view/308194466/
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: May 26th, 2017
University of PennsylvaniaPhiladelphia, PAPhDALSMay 26, 2017
Postdoctoral Fellow, Neurodegeneration

Postdoctoral Fellow, Neurodegeneration

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Description:

van Geest Post-Doctoral Fellowships in Neurodegeneration



Kings College London is making a major investment in Dementia and Neurodegeneration research, with the creation of the van Geest Chair in Dementia and Three Post-Doctoral Fellowships. Several other Principal Investigator posts in Dementia and Neurodegeneration are also advertised at the level of Professor, Senior Lecturer or Lecturer. They will be based in the newly built Maurice Wohl Clinical Neuroscience Institute.


We are seeking to appoint three senior post-doctoral neuroscientists, funded for a three year period to develop an independent programme of neurodegeneration research and obtain longer-term funding. Their approach might include genetic, molecular, cellular, model organisms, electrophysiological and imaging methodologies in a preclinical or clinical setting. The key objective of the post is to establish an independent research niche within the department.


The salary will be paid at Grade 7, £40,523 to £48,327 per annum, plus £2,623 per annum London Allowance.


The selection process will include a presentation and panel interview, and may include a formal lecture to members of the university.


The deadline for applications is 30th June 2017.

Interviews dates are TBC.


For an informal discussion to find out more about the role please contact Prof Christopher Shaw on +44(0)207 848 0259 or email chris.shaw@kcl.ac.uk


To apply for this role, please visit https://www.hirewire.co.uk/HE/1061247/MS_JobDetails.aspx?JobID=76884 and register to download and submit the specified application form.


Link: https://www.hirewire.co.uk/HE/1061247/MS_JobDetails.aspx?JobID=76884
Employer: King's College London
Location: London, England
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 18th, 2017
Applications close: June 30th, 2017
King's College LondonLondon, EnglandPhDNDGMay 18, 2017
Clinical Senior Lecturer

Clinical Senior Lecturer

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Description:

Kings College London is making a major investment in Dementia and Neurodegeneration research with several new Principal Investigator Posts and Fellowships. We are looking to appoint an exceptional clinical Neuroscientist who shares our ambition to make KCL one of the world’s leading centres for Dementia and Neurodegeneration Research. They will be based in the newly built Maurice Wohl Clinical Neuroscience Institute. The post will be supported by a competitive start-up package and a significant equipment budget.


Applications are welcomed from investigators whose work focuses on exploring fundamental disease mechanisms, preclinical studies and fully translational intervention across all aspects of Dementia and other Neurodegenerative disorders. Collaborative links to biotechnology and pharmaceutical industries are welcome. Ultimately, success will be measured by high impact publication output, success in attracting research funding, contribution to teaching and the scientific strategy of the Department.


The selection process will include a presentation and panel interview, and may include a formal lecture to members of the university.


The deadline for applications is midnight on 30 June 2017.


Interview dates are TBC.


For an informal discussion to find out more about the role please contact Prof Christopher Shaw on +44(0)207 848 0259 or email chris.shaw@kcl.ac.uk


To apply for this role, please visit https://www.hirewire.co.uk/HE/1061247/MS_JobDetails.aspx?JobID=76888 and register to download and submit the specified application form.


Link: https://www.hirewire.co.uk/HE/1061247/MS_JobDetails.aspx?JobID=76888
Employer: King's College London
Location: London, England
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 17th, 2017
Applications close: June 30th, 2017
King's College LondonLondon, EnglandPhDNDGMay 17, 2017
Senior Lecturer

Senior Lecturer

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Description:

Kings College London is making a major investment in Dementia and Neurodegeneration research with several new Principal Investigator Posts and Fellowships. We are looking to appoint an exceptional Neuroscientist who shares our ambition to make KCL one of the world’s leading centres for Dementia and Neurodegeneration Research. They will be based in the newly built Maurice Wohl Clinical Neuroscience Institute. The post will be supported by a competitive start-up package and a significant equipment budget.


Applications are welcomed from Investigators whose work focuses on exploring fundamental disease mechanisms, preclinical studies and fully translational intervention across all aspects of Dementia and other Neurodegenerative disorders. Collaborative links to biotechnology and pharmaceutical industries are welcome. Ultimately, success will be measured by high impact publication output, success in attracting research funding, contribution to teaching and the scientific strategy of the Department.


The selection process will include a presentation and panel interview, and may include a formal lecture to members of the university.


The deadline for applications is 30th June 2017.

Interviews are scheduled T.B.C.


For an informal discussion to find out more about the role please contact Prof Christopher Shaw on +44(0)207 848 0259 or email chris.shaw@kcl.ac.uk


To apply for this role, please visit https://www.hirewire.co.uk/HE/1061247/MS_JobDetails.aspx?JobID=76879 and register to download and submit the specified application form.


Link: https://www.hirewire.co.uk/HE/1061247/MS_JobDetails.aspx?JobID=76879
Employer: King's College London
Location: London, England
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 17th, 2017
Applications close: June 30th, 2017
King's College LondonLondon, EnglandPhDNDGMay 17, 2017
Assistant Professor, Neuroscience and Cell Biology

Assistant Professor, Neuroscience and Cell Biology

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Description:

Specific Job Related Duties


Participate in training investigators in the areas of neurodegenerative disease and otherdisorders of the nervous system


Partner with established biomedical researchers in a highly collaborative biomedical researchcommunity to foster mutual scientific goals


Build translational research programs


Participate in committees which serve the Department, and the University


Preferred Skill/Competency


Ability to collaborate within a team of researchers in a translational and basic science researchresearch setting


Excellent command of the English language both written and spoken


Preferred Work Experience


Ability to collaborate across scientific disciplines


Link: http://utmb.jobs/galveston-tx/assistant-professor-neuroscience-cell-biology/637E2506D7C14A01A2D91B1D6E94C788/job/
Employer: University of Texas
Location: Galveston, TX
Sector: Academia
Degree required: PhD or MD
Conditions: NDG
Job posted: May 16th, 2017
University of TexasGalveston, TXPhD or MDNDGMay 16, 2017
Clinical Senior Lecturer, Neuropathology

Clinical Senior Lecturer, Neuropathology

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Description:

We are looking to appoint a Clinical Senior Lecturer/Reader in Neuropathology to join the Centre for Neuroinflammation and Neurodegeneration (CNN), where they will undertake a programme of research in Neuropathology as well as becoming one of the directors of the UK MS and PD Tissue Bank, and contribute to the clinical neuropathology service at Imperial College Healthcare Trust.


The CNN researches neurodegeneration and neuroinflammation, neuropathological studies, neuroimaging methods, and therapeutic monitoring, as well as clinical translation and trial development for novel therapies.


We are interested in hearing from academics with a track record of high quality publications in Neurodegenerative mechanisms contributing to Multiple Sclerosis and Parkinson’s disease. However we will be pleased to consider those with other interests that impact on Neuropathology.


The level of appointment and supporting package will be determined according to experience and research profile using the following guidelines:


As Clinical Senior Lecturer you will have extensive professional experience and be able to demonstrate a reputation in the area of Neuropathology based on your research. You will be expected to show independence through original research work, and demonstrate your aptitude for teaching.


For appointment as Clinical Reader you will have developed an international reputation based on a track record of research in Neuropathology, and consistently demonstrate the ability to attract research income. You will be an experienced teacher with the potential to develop and deliver educational programmes.


For either level you will have full GMC registration with a licence to practise (or be eligible for registration within six months of interview), have completed your CCT and hold membership of the Royal College of Pathologists. You will have extensive experience of the diagnostic neuropathological service of neoplastic, inflammatory, neurodegenerative and vascular disease, including intraoperative assessment, as well as skill in carrying out muscle and peripheral nerve biopsies.


Imperial College provides an outstanding environment for basic, clinical and translational research, and supports academics through tailored training programmes, with mentoring and comprehensive administrative support. This is a fantastic opportunity for an individual with the ability to develop their original ideas, lead a research group and work to be among the best in the field.Imperial College s happy to discuss the possibility of part-time working subject to operational requirements.


Informal enquiries can be made to Professor Richard Reynolds r.reynolds@imperial.ac.ukOur preferred method of application is online via our website by clicking the apply button.


Please complete and upload an application form as directed quoting reference number HM2017070.If you are unable to apply online, please email f.whyte@imperial.ac.uk to request an application form.Closing Date: Thursday 29th June 2017 (Midnight BST)


Link: https://jobs.bmj.com/job/59232/clinical-senior-lecturer-reader-in-neuropathology/
Employer: Imperial College London
Location: London, England
Sector: Academia
Degree required: Licensed Neuropathologist
Conditions: NDG
Job posted: May 16th, 2017
Applications close: June 29th, 2017
Imperial College LondonLondon, EnglandLicensed NeuropathologistNDGMay 16, 2017
Postdoctoral Fellow, Neurogenetics

Postdoctoral Fellow, Neurogenetics

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Description:

As postdoc you will be working on data from Project MinE (www.projectmine.com). This is unique genomic dataset in the field of Amyotrophic Lateral Sclerosis (ALS), a rapidly progressive, invariably fatal neurological disease that attacks the nerve cells responsible for controlling voluntary muscles, which include epigenetic, whole genome sequencing and clinical data of several thousand of ALS patients and matched controls. We have recently published the first results of this dataset (Van Rheenen et al. Nat Genet. 2016 (PMID: 27455348), and Kenna et al. Nat. Genet. 2016 (PMID: 27455347)). Your focus will be on exploring adding external controls and cases to this dataset while preserving type I error in case-control comparisons, annotating the non-coding genome by integrating our data with other publicly available omics datalayers, including RNAseq, Hi-C and Chip-seq and relating this to case-control status. Another type of genomic variation potentially related to ALS we are interested in, is structural variation. This means you need to have experience in working with raw sequencing data on a large number of samples and be able to apply complex genetic statistics in this context. There is a suitable ICT setup available for you to achieve this. We expect you to be able to use various bioinformatic tools on next-generation sequencing data and combine these to identify possible novel ALS risk genes, and pathological pathways. Also, we would like you to integrate these genetic data with drug databases in order to prioritize potential new drug targets for ALS and repurposing of existing drugs for ALS. This part of the work will be done in collaboration with a biotech company. You will also be expected to participate in writing scientific papers and grant applications, provide methodological advice to other members of the team (bioinformaticians, PhD students, postdocs, technicians), and participate in educating bachelor and master students.


Link: http://www.werkenbijumcutrecht.nl/vacatures/paginas/postdoc-neurogenetics%20(2017-0434).aspx?ccs=1
Employer: UMC Utrecht
Location: Utrecht, The Netherlands
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: May 16th, 2017
UMC UtrechtUtrecht, The NetherlandsPhDALSMay 16, 2017
Assistant Professor, Genetics

Assistant Professor, Genetics

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Description:

The Centre for Integrative Biology of the University of Trento invites candidates active in Genetics to apply for a position at the Assistant Professor level. The position is offered for a three-year period. The annual gross salary will be about 45.000 Euros. The area of research and teaching is Genetics:


Requested research duties: mechanistic and molecular studies on the processes underlying the genesis and the progression of neurodegenerative diseases, also based on the use of genome-scale approaches.


Requested teaching duties: teaching activity in the subject area of Genetics for Bachelor, Master’s and PhD students.


Link: http://jobs.sciencecareers.org/job/450701/assistant-professor-in-genetics/
Employer: University of Trento
Location: Trento, Italy
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 15th, 2017
University of TrentoTrento, ItalyPhDNDGMay 15, 2017
Assistant Professor, Neuroimaging

Assistant Professor, Neuroimaging

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Description:
Assistant professor to be hired will be working in the research group of Associate Professor Eric Westman which is localized within the Geriatrics Laboratories in the Novum building at KI Campus Huddinge. The focus of the research group has long been on different imaging modalities such as magnetic resonance imaging (MRI) and positron emission tomography (PET) and its applications in neurodegenerative disorders. The assistant professor will work in many different projects related to healthy ageing and dementia, always with as strong focus on neuroimaging and advanced analysis methods such as graph theory.


Duties


A major task for the applicant will be to contribute to the ongoing research activities at the division of clinical geriatrics, conceptually as well as methodologically. In particular, the person is expected to take an active role in our multimodal imaging work, integrating different image modalities, advanced statistical methods and graph theory with genetic, cognitive and biomarker data. Further, there are possibilities to initiate individual research projects, based on the person´s interests.The successful candidate should show a high level of responsibility and independency and be able to work in a team and be willing to supervise students. Moreover, the candidate is expected to have broad knowledge and expertise in aging research and dementia, data gathering and analysis as well as manuscript and grant preparation. Help with coordination of projects within the division and writing grant applications are also duties included as part of the position.


Entry Requirements


A person is eligible to be appointed Assistant professor if he or she has been awarded a Degree of Doctor or has achieved the corresponding scientific competence. The persons appointed should primarily be ones who have been granted a Degree of Doctor or have reached the corresponding competence no more than seven years before the end of the application period.We seek for a scientist with a minimum of four years postdoc experience in the field of neuroimaging in aging, Parkinson’s disease and Alzheimer’s disease research. The candidate should be able to conduct advanced image data processing/analysis (Freesurfer, SPM, FSL and Matlab) and have knowledge about graph theory. The candidate should have previous expertise working Alzheimer’s disease as well as other neurodegenerative disorders.


Bases of assessment


We stress scientific expertise when assessing applicants. A strong track record in terms of publications, as well as research experience in graph theory as well as structural and functional neuroimaging data analysis in Alzheimer’s disease and Parkinson’s disease is required. Documented experience in longitudinal analysis of imaging and behavioral data is desirable. The applicant should also have experience in using a few of the most commonly available imaging software such as Freesurfer, FSL and SPM. The applicant is expected to show independence in terms of research initiatives as well as to have good collaborative skills.


Application process


An application must contain the following documents in English: Curriculum vitae, qualifications and description of planned research, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/qualificationsportfolio).The application is to be submitted through the MyNetwork recruitment system.An Assistant professor position is a fixed-term position. The first employment should be two years, with a possible extension of two years after evaluation.

Link: https://ki.mynetworkglobal.com/se/what:job/jobID:151669/type:job/where:4/apply:1
Employer: Karolinska Institutet
Location: Huddinge, Sweden
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 15th, 2017
Applications close: June 5th, 2017
Karolinska InstitutetHuddinge, SwedenPhDNDGMay 15, 2017
Assistant Scientist III, Neurodegeneration

Assistant Scientist III, Neurodegeneration

(Click title to open job details in a new window.)
Description:

The Institute Assistant Scientist III participates in cross-functional research to identify and validate novel targets for neurodegenerative diseases, and translate these finding into novel therapeutic agents to benefit patients. An ideal candidate will be able to work in an interdisciplinary team to support our internal drug discovery efforts as well as to propose novel approaches to optimize and increase throughput of drug discovery projects.


Key functions:


*Under minimal supervision, contribute to carefully planned project activities through laboratory experiments.

*Help establish and validate novel assays for evaluating therapeutic targets.

*Independently design and execute pharmacological studies involving cellular models of neurodegeneration and neuroinflammation.

*Use cell biological, biochemical, and molecular biological techniques across a wide range of neurodegeneration projects.

*Works closely with research team to identify and recommend opportunities leading to the discovery of neurodegeneration related genes/pathways/targets to further advance scientific discovery and clinical therapeutic drug development.

*Utilize immunohistochemical techniques in brain slices to identify specific expression of relevant proteins following in vivo drug dosing experiments.

*Analyze data and prepare written and oral reports to project teams.

*Interact closely with other research staff across institutional functional teams.

*Participate in an integrated drug discovery research team by engaging in interaction with scientists of different disciplines.


Experience Required: Three years of relevant research experience in lab. With preferred degree, one year of required experience.


Experience Preferred: Strong technical abilities in rodent behavioral assays with chronic dosing, proven experience in experimental planning and data interpretation, and experience in histology techniques.


Link: http://www.nature.com/naturejobs/science/jobs/614491-institute-assoc-scientist-iii-neurodegeneration-consort
Employer: MD Anderson
Location: Houston, TX
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 12th, 2017
Applications close: July 11th, 2017
MD AndersonHouston, TXPhDNDGMay 12, 2017
Postdoctoral Fellow, Respiratory Physiology

Postdoctoral Fellow, Respiratory Physiology

(Click title to open job details in a new window.)
Description:

Applications are being solicited for two NIH post-doctoral fellowships in respiratory neurobiology at the University of Wisconsin-Madison. The first position will investigate cellular mechanisms and physiological significance of neuroplasticity in the control of breathing, with an emphasis on sleep apnea. The second position will investigate functional outcomes of ex vivocell therapy (stem cell-based trophic factor delivery) to preserve respiratory motor neuron and diaphragm function in rodent models of Amyotrophic Lateral Sclerosis (ALS).


Job Duties: Candidates will perform in vivo neurophysiological recordings from phrenic nerves and diaphragm EMGs as part of a highly collaborative team, including respiratory neurobiologists (Tracy Baker, UW-Madison and Gordon Mitchell, University of Florida) and a stem cell biologist (Masatoshi Suzuki; UW-Madison). Although previous experience with in vivoelectrophysiology is desirable, the candidate will be intensively trained in the necessary techniques. Expertise in telemetry implantation, plethysmography, immunohistochemistry, and/or protein and RNA assays are preferred.


Requirements: Ph.D. or equivalent in physiology, neuroscience or a related field. The individual should have strong interest in in vivo experimental approaches. The successful candidate must be a team player, think critically, and communicate effectively. Salary is compatible with NIH pay schedule.


Applications should include a cover letter describing major achievements and skills, a curriculum vitae and contact information of three professional references. Please send applications to Dr. Tracy Baker (tracy.baker@wisc.edu).


Link: http://jobs.sciencecareers.org/job/450119/postdoctoral-positions-in-respiratory-neurobiology/
Employer: University of Wisconsin
Location: Madison, WI
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: May 11th, 2017
University of WisconsinMadison, WIPhDALSMay 11, 2017
Research Scientist

Research Scientist

(Click title to open job details in a new window.)
Description:

The researcher will be devoted to the development of advanced techniques of in vivo Clinical Biochemistry, in particular metabolic (MR spectroscopy), microstructural and molecular (diffusion tensor imaging) and functional (fMRI) imaging, for the study of the central nervous system and neuromuscular system. The research activity will be applied to inflammatory, neurometabolic, neurodegenerative and neoplastic disorders, aimed to a) the identification of early diagnostic and prognostic markers and surrogate markers of treatment; b) the characterization of brain activations patterns; c) optimization of structural and functional connectivity analysis.


Link: http://jobs.sciencecareers.org/job/450386/central-nervous-system-and-skeletal-muscle-system-evaluation-by-using-biochemical-and-functional-/
Employer: University of Bologna
Location: Bologna, Italy
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 10th, 2017
University of BolognaBologna, ItalyPhDNDGMay 10, 2017
Postdoctoral Fellow

Postdoctoral Fellow

(Click title to open job details in a new window.)
Description:

We are seeking a Postdoctoral Research Scientist in Cell Based High Throughput Screening for Neurodegeneration who will be responsible for developing cellular assays relevant to neurodegenerative diseases, scaling them down to microtiter format and running phenotypic or target based screenings using CRISPR, si/shRNA or small molecule compound libraries.


You will be a highly organised and productive member of a growing high throughput screening team aiming to manage and deliver multiple projects per year, as well as of the ODDI aiming to develop novel therapeutics for the treatment of dementia. We actively encourage scientists from all disease backgrounds, but with the necessary assay development and cellular screening experience to apply.


You will have a PhD or equivalent expertise, with considerable practical laboratory training and technical expertise in all aspects of high content imaging cellular techniques with particular emphasis on developing and validating cell based assays.


You will have experience in managing several complex projects simultaneously and have meticulous record keeping skill. In addition an established record of authorship and/or examples of successful assay development implemented into high throughput screening format and some experience supporting collaborative grant applications by providing technical scientific input is a desired requirement.


This full-time position is fixed-term for 2 years with the possibility of extension.


Further particulars, including details of how to apply, can be obtained from the document below. Applications for this vacancy should be made online and you will be required to upload a CV and supporting statement as part of your application.


The closing date for applications is 12.00 noon on Thursday 8 June 2017.


Link: https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.display_form?p_process_type=&p_applicant_no=&p_internal_external=E&p_refresh_search=Y&p_recruitment_id=128765&p_display_apply_ind=Y&p_form_profile_detail=&p_display_in_irish=N&p_company=10
Employer: University of Oxford
Location: Oxford, England
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 9th, 2017
Applications close: June 8th, 2017
University of OxfordOxford, EnglandPhDNDGMay 09, 2017
Postdoctoral Fellow, Van Damme Lab

Postdoctoral Fellow, Van Damme Lab

(Click title to open job details in a new window.)
Description:

The Laboratory of Neurobiology is part of the research group Experimental Neurology (Neuroscience Department) at KU Leuven. The group has a close collaboration with the Neurology Department of the University Hospitals Leuven with about 50 researchers in different domains.


In addition, the laboratory is one of the research groups of the VIB Center for Brain & Disease Research (CBD) at KU Leuven/ Campus Gasthuisberg focusing on Neuroscience. There are 13 research groups within the CBD with a total employment of 230 researchers.


The Laboratory focusses on clinical and fundamental research into the prevention, heredity, the pathogenesis and treatment of neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD).


Project:


The research project, under supervision of principal investigator Philip Van Damme, will focus on the neurodegenerative disorder frontotemporal dementia caused by progranulin mutations and will involve in vitro techniques, validation of neuroprotective compounds, iPSCs and small animal models.


Profile


​We are looking for a highly motivated postdoctoral researcher with interest in neurodegeneration and experience in progranulin biology and/or iPSC technology. Motivated candidates with a strong commitment to basic research are invited to apply.


The candidate should hold a PhD degree in biomedical sciences, have experience in research on neurodegenerative disorders, progranulin biology and/or iPSC technology, be able to work in a team, be able to guide and supervise PhD students and should fluently speak and write English.


Link: http://www.vib.be/en/jobs/Pages/Postdoctoral-Researcher-on-new-iPSC-Models-in-Neurodegeneration.aspx
Employer: VIB
Location: Leuven, Belgium
Sector: Academia
Degree required: PhD
Conditions: ALS, FTD
Job posted: May 8th, 2017
VIBLeuven, BelgiumPhDALS, FTDMay 08, 2017
Research Scientist

Research Scientist

(Click title to open job details in a new window.)
Description:

Under general direction of the Principal Investigator (PI), leadership investigators, and project manager, the incumbent will undertake project activities under a CIRM award developing an embryonic stem cell-based therapy to treat Amyotrophic Lateral Sclerosis (ALS), making innovative and significant independent contributions pertaining to achievement of project milestones.


The incumbent must coordinate specific project activities and individuals across multiple functional areas and organizations, including management of routine cell culture, cell biology and molecular techniques, as well as, development and qualification of new clinically translatable analytical methods for characterizing identity and functional activity of pluripotent stem cells and neural lineage cells.


The incumbent will also perform data analysis on mRNA sequencing data and build a database of sequenced cells to support in vivo and in vitro characterization activities and identify potential markers of safety, efficacy and/or disease progression. Additional responsibilities include independent and collaborative organization, outline, evaluation and preparation of scientific data, results, methods, and conclusions in formal and informal formats including presentations, research manuscripts, funding initiatives, and regulatory submissions; and other tasks as required by project investigators.


Link: http://www.cellbiologyjobs.org/jobs/9027565/stem-cell-molecular-biology-researcher
Employer: University of California
Location: San Diego, CA
Sector: Academia
Degree required: BA or BS
Conditions: ALS
Job posted: May 2nd, 2017
University of CaliforniaSan Diego, CABA or BSALSMay 02, 2017
Clinical Psychologist

Clinical Psychologist

(Click title to open job details in a new window.)
Description:

We are seeking a Clinical Psychologist with a strong interest in neuroscience and experience in neuropsychological assessment to join a well-established multidisciplinary neuroscience team specialising in early onset and/or rare dementias.


You will be located in the Cerebral Function Unit at Salford Royal NHS Foundation Trust, a tertiary referral diagnostic unit set within a regional neuroscience centre.


The Unit is a clinical academic unit that was set up with the aim of improving clinical services to patients with neurodegenerative disorders by greater accuracy of clinical diagnosis and better understanding of the cognitive and behavioural sequelae of dementia syndromes, including Alzheimer’s disease, frontotemporal dementias and primary progressive aphasias. The unit has an international reputation for research in neurodegeneration.


The primary role of the post-holder is to contribute to a specialist diagnostic service for patients referred to the unit for the purposes of differential diagnosis of dementia.

This is an excellent opportunity to join an outstanding Trust.


Must be a registered clinical psychologist in the UK.


For further details contact Dr Jennifer Thompson by tel. 0161-206-2561 or email jennifer.thompson@manchester.ac.uk


Link: http://jobs.srft.nhs.uk/job/v673304
Employer: Salford Royal NHS Foundation Trust
Location: Salford, England
Sector: Academic
Degree required:
Conditions: FTD
Job posted: May 1st, 2017
Salford Royal NHS Foundation TrustSalford, EnglandFTDMay 01, 2017
Lab Manager

Lab Manager

(Click title to open job details in a new window.)
Description:

The position is for a Lab Manager to help facilitate all daily lab operations. The individual will report to a Principal Investigator (PI) in neuropathology research that investigates the pathogenesis of Alzheimer’s disease, frontotemporal dementia, and related disorders. A successful candidate will have excellent communication skills, highly confident decision making ability, experience managing multiple projects and life sciences lab management, and embrace the highly dynamic environment.

Responsibilities include: maintaining lab consumables inventory, equipment maintenance, communicating with vendors, safety training, and scientist support of a growing Laboratory.


Link: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?partnerid=6495&siteid=5226&jobId=2474136
Employer: University of California
Location: San Francisco, CA
Sector: Academia
Degree required: BS
Conditions: FTD
Job posted: April 30th, 2017
University of CaliforniaSan Francisco, CABSFTDApr 30, 2017
Graduate Research Assistant

Graduate Research Assistant

(Click title to open job details in a new window.)
Description:

The laboratory is seeking a motivated Graduate Research Assistant to join our efforts in exploring disease mechanisms and developing therapeutic strategies for amyotrophic lateral sclerosis (ALS) and dementia. There is an increased focus on altered RNA processing as a central component of neurodegeneration in ALS and frontotemporal dementia. Our group explores the role of RNA alterations in neuronal death and uses splicing and expression profiles to identify therapeutic strategies that correct disease-linked gene expression events. The successful candidate will lead a research project using various cellular and animal models of ALS to explore disease mechanisms. Under the supervision of the Principal Investigator, the candidate will design and perform experiments, will participate to the scientific lab meetings and is expected to fully participate in the organization and joint upkeep of the laboratory. He/She will perform laboratory experiments which include DNA and RNA purification, quantitative PCR, gel electrophoresis, Western blots, DNA cloning, immunostaining, preparation of libraries for high throughput sequencing, and mammalian cell cultures. Experience in mouse handling and mouse histology is preferred. The individual must pay attention to details, be capable of working independently under minimal supervision, possess good verbal and written communication skills, and work well as part of a team.


The candidate must be enrolled in a graduate program (MS/PhD Student) in a relevant scientific discipline such as biochemistry, biology, molecular biology or related field.


Link: https://partners.taleo.net/careersection/ex/jobdetail.ftl?job=3038715&src=JB-10326
Employer: Massachusetts General Hospital
Location: Boston, MA
Sector: Academia
Degree required: BA or BS
Conditions: ALS, FTD
Job posted: April 27th, 2017
Massachusetts General HospitalBoston, MABA or BSALS, FTDApr 27, 2017

Industry

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
NEW! Postdoctoral Fellow

Postdoctoral Fellow

(Click title to open job details in a new window.)
Description:

Sanofi’s Neuroscience Research Therapeutic Area based in Framingham, MA is looking for a highly qualified and motivated Postdoctoral Scientist to investigate the underlying disease biology of amyotrophic lateral sclerosis (ALS). The successful candidate will implement manifold in vitro and in vivo experimental approaches to help identify and validate innovative therapeutic targets for the treatment of ALS. These techniques include molecular biology, biochemistry, cell culture, immunoblotting, immunohistochemistry, microscopy, laser capture microdissection and the use of transgenic mouse models.


Responsibilities


Design and execute experimental strategies to understand the manner in which TDP-43 mislocalization contributes to ALS disease pathogenesis

Establish in vitro cell based models (astrocytes and motor neurons) of ALS

Conduct in vivo experimental work (clinical scoring, motor testing and tissue collection) using transgenic mouse models of ALS

Implementation of multiple state-of-the-art techniques in molecular biology, biochemistry, and microscopy

Analyze, interpret, and present experimental results at lab meetings.

Publish/present findings in peer-reviewed journals/scientific conferences.

Maintain accurate records of experiments and analyses.

Maintain lucid and effective communication with manager and other colleagues.


Basic Qualifications:


Ph.D. in Neuroscience or related field, with at 0-3 years of postdoctoral training

Previous first-author publication(s) in internationally recognized journals are required

Ability to meet aggressive timelines and deliverables in a collaborative environment

Excellent speaking, reading and writing skills

Strong analytical and organizational skills

Curiosity and a willingness to work independently

All candidates must have authorization to work in the United States throughout the duration of the Fellowship. No visa sponsorship will be provided


Link: https://jobs.sanofi.us/job/framingham/postdoctoral-fellowship-neuroscience-research/18104/4949481
Employer: Sanofi
Location: Framingham, MA
Sector: Industry
Degree required: PhD
Conditions: ALS
Job posted: June 21st, 2017
SanofiFramingham, MAPhDALSJun 21, 2017
NEW! Senior Associate Scientist, ALS and PD

Senior Associate Scientist, ALS and PD

(Click title to open job details in a new window.)
Description:

We are seeking a Research Senior Associate Scientist to join a vibrant and growing group currently focusing on Neurodegenerative diseases within the Neuroscience Therapeutic Area, a key component of the Discovery Research unit at Amgen’s site in Cambridge, MA (Amgen MAssachusetts-AMA). The successful candidate must be highly motivated with a deep interest in developing new and effective therapeutics for Parkinson’s disease (PD)/ALS.


Position Responsibilities

Conduct biochemical and cell-based experiments/assays to evaluate novel mechanisms and interrogate the biology of new therapeutic targets for PD/ALS

Carry out experiments required to rigorously evaluate in-licensing opportunities

Critically analyze and interpret data, and meet delivery deadlines

Work closely with and communicate results to multi-disciplinary and cross-functional teams

Execute high impact studies within an extremely fast-paced and collaborative environment


Link: https://careers.amgen.com/job/7265433/sr-associate-scientist-parkinsons-disease-als-cambridge-ma/
Employer: Amgen
Location: Cambridge, MA
Sector: Industry
Degree required: BS or MS
Conditions: ALS
Job posted: June 20th, 2017
AmgenCambridge, MABS or MSALSJun 20, 2017
Scientist I/II, NeuroImmunology

Scientist I/II, NeuroImmunology

(Click title to open job details in a new window.)
Description:

The Biogen Department of NeuroImmunology seeks a highly motivated and keen experimentalist whose primary responsibility is to advance drug discovery and development by performing bench research. The individual will be expected to design studies and execute research aimed at target discovery as well as the development of therapeutic approaches to treat acute neurological indications and chronic neurodegenerative diseases. The individual is expected to function independently and creatively within the context of project teams, drawing on pertinent literature, and to foster collaborations to maximize synergies and cross disciplinary approaches to advance the studies. The work will involve a wide array of in vitro and in vivo techniques and is expected to yield high quality publications.


Responsibilities include:


• Skilled experimentation; independent design, execution and analysis of experiments.


• Role as key contributor on project teams; collaborative conduct with internal and external investigators


• Development and delivery of effective presentations; ability to defend work. Preparation of high quality manuscripts, research project reports, or invention disclosures.


Link: https://jobs.biogen.com/job/Cambridge-Scientist-III%2CNeuroImmunology%2C-Research-and-Early-Development-MA-02138/406286600/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: June 8th, 2017
BiogenCambridge, MAPhDNDGJun 08, 2017
Electrophysiologist

Electrophysiologist

(Click title to open job details in a new window.)
Description:

The Musculoskeletal disease area research department at the Novartis Institutes for BioMedical Research (NIBR) in Basel, Switzerland, is looking for a Scientific Associate with excellent electrophysiology skills to join a highly motivated research team that aims to identify and develop therapies for neuromuscular diseases and peripheral neuropathies like amyotrophic lateral sclerosis and sarcopenia.


• You will be primarily responsible for conducting experiments using in vitro models for compound assessment and target validation

• You will have the chance to use your broad technical skills in cell and molecular biology techniques in addition to your core electrophysiology expertise

• You will independently design experiments and perform statistical evaluations

• Using your effective organizational skills you will contribute to experimental planning and the global maintenance of the laboratory

• This position offers the opportunity to work in a multi-disciplinary environment and to actively contribute to the discovery and development of new therapies for musculoskeletal diseases.


Link: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?partnerid=13617&siteid=5260&alcon&jobId=2486513
Employer: Novartis Pharma AG
Location: Basel, Switzerland
Sector: Industry
Degree required: BS or MS
Conditions: ALS
Job posted: May 24th, 2017
Novartis Pharma AGBasel, SwitzerlandBS or MSALSMay 24, 2017
Neurobiology Research Associate II

Neurobiology Research Associate II

(Click title to open job details in a new window.)
Description:

Verge Genomics is seeking a Neurobiology Research Associate II to join the Drug Discovery team. This candidate will gain pharmaceutical industry experience in a cutting-edge academic lab in the SF Bay Area and at Verge Genomics headquarters in SF. The candidate will be part of a multifunctional team with responsibility for target validation and evaluation of novel drug candidates for neurodegenerative diseases. The candidate will conduct in vivo studies in mice, including neonatal intracerebroventricular injections, and drug administration by oral routes. Experience with stereotaxic surgery, gene therapy (AAV9 or ASO), behavioral observations, gait analysis, rotarod and grip strength, and genotyping are a plus. The ideal candidate will have excellent problem-solving skills and familiarity with statistical analysis. This position reports to a PhD Scientist. The candidate will also culture motor neurons differentiated from induced pluripotent human stem cells and aid in the design and development of cellular assays to identify genes and compounds for treating neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). The candidate will have extensive experience with sterile in vitro laboratory tasks, including harvesting, storing, growing, and expanding neuronal cultures, formulating and adding compounds and molecular probes, measuring cell numbers with light microscopy and properties based on immunohistochemical markers, and writing SOPs and detailed records of all work.


Link: https://www.linkedin.com/jobs/view/350934360/
Employer: Verge Genomics
Location: San Francisco, CA
Sector: Industry
Degree required: BS or MS
Conditions: ALS
Job posted: May 24th, 2017
Verge GenomicsSan Francisco, CABS or MSALSMay 24, 2017
Scientist, Neurological Rare Disease

Scientist, Neurological Rare Disease

(Click title to open job details in a new window.)
Description:

Sanofi’s Neuroscience Research Therapeutic Area based in Framingham, MA is looking for a highly qualified and motivated Scientist to develop therapies for rare neurologic and neurodegenerative diseases. This laboratory based position will include the opportunity to lead project teams and interact with internal and external functions to initiate new drug discovery programs and advance ongoing projects. The candidate will use epigenetics tools, genome editing technologies, –omics, bioinformatics and other approaches to identify and validate new targets. The candidate will also advance understanding of the role of the non-coding genome to identify and validate innovative and transformative therapies for rare neurologic diseases.


Link: https://sanofi.wd3.myworkdayjobs.com/en-US/Sanoficareers/job/Framingham-MA/Scientist--Neurological-Rare-Disease_R1267-1
Employer: Sanofi
Location: Framingham, MA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: May 24th, 2017
SanofiFramingham, MAPhDNDGMay 24, 2017
Research Associate II/III

Research Associate II/III

(Click title to open job details in a new window.)
Description:

Summary


We are seeking a talented Research Associate to join VelociGene’s neurodegenerative disease research team. The individual will be involved in basic research studies designed to understand the biology behind various neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis, Alzheimer’s, Parkinson’s, and Huntington’s.


Responsibilities


The goal will be to identify and validate novel therapeutic targets and mechanisms. Additionally, this position will support and expand the development of new technologies, to this same end. This candidate will work within a multi-disciplinary group; we are looking for a highly organized, flexible and motivated research associate.


Requirements



  • Experience in molecular and cellular biology and biochemistry

  • Experience with cell based assays (Western Blot, ELISA, FACS) preferred

  • Experience in creating and managing vector constructs and projects

  • Experience with mammalian tissue culture

  • Experience in the maintenance and differentiation of embryonic stem cells

  • Experience with CRISPR and other genome editing tools a plus

  • Excellent communication skills and computer proficiency are also required

  • This position requires a minimum of a BS or MS degree and 0-4 years of relevant experience.

  • At least two years’ postgraduate experience. Experience in a neurobiology lab would be highly desirable. Equivalent industrial experience would also be acceptable.

  • A high level of skill in cellular and molecular biology and biochemistry experimental techniques

  • Preferred knowledge would include neurobiology and the growth and maintenance of cells of the nervous system; knowledge of protein homeostasis, protein folding, and quality control mechanisms and protein aggregation

  • Ability to work independently with limited supervision but also be a productive and cooperative member of a diverse research team.

  • Ability to manage multiple projects


Link: http://careers.regeneron.com/job/REGEA0026303504/Research-Associate-II-III-Neurodegenerative-Diseases
Employer: Regeneron
Location: Tarrytown, NY
Sector: Industry
Degree required: BS or MS
Conditions: ALS
Job posted: May 16th, 2017
RegeneronTarrytown, NYBS or MSALSMay 16, 2017
Scientist, Neuroscience

Scientist, Neuroscience

(Click title to open job details in a new window.)
Description:

Genentech is inviting applications for a Scientist position (rank equivalent to assistant professor in academia) in the Department of Neuroscience. We are seeking an exceptional, highly motivated and creative scientist to lead innovative research efforts focused on unraveling the mechanisms of neurodevelopment and/or brain function in the context of nervous system diseases. He/she will also be expected to participate in inter-disciplinary teams to identify novel drug targets and discover new drugs to treat nervous system disorders. The ideal candidate will have significant experience in molecular and cellular biology using both in vitro and in vivo model systems, and possess a deep mechanistic understanding of the cellular pathways that contribute to diseases of the nervous system (e.g. neurodegenerative diseases). A solid track record of publications in top tier journals is required as is exceptional communication skills. The position will involve close collaboration with other research labs in Neuroscience as well as investigators in areas such as human genetics, bioinformatics, proteomics, imaging, and small molecule and large molecule drug discovery. The successful candidate will be expected to publish their research in high quality journals.


As a strong candidate, you will have:

PhD with postdoctoral research experience in cell biology, neuroscience or related areas in life sciences.

Record of impactful research in molecular cellular biology, neuroscience, or related fields, as evidenced by recent first authored publications in top-tier journals.

Excellent written and oral communication skills

The drive and ability to lead an independent research group and collaborate with other investigators

Outstanding promise of future scientific achievement


Link: https://www.gene.com/careers/detail/3398510619/Scientist-Neuroscience-Genentech-Research
Employer: Genentech
Location: San Francisco, CA
Sector: Industry
Degree required: PhD
Conditions: NDG
Job posted: May 4th, 2017
GenentechSan Francisco, CAPhDNDGMay 04, 2017
Director, Neurobiology

Director, Neurobiology

(Click title to open job details in a new window.)
Description:

Verge Genomics is seeking a motivated and accomplished Director of Neurobiology with experience using in vivo pharmacology models to translate in vitro compound hits to optimized drug leads. You will lead in vivo studies to validate small molecule efficacy and minimize side effect potentials and establish proof of concept by the manipulation of gene targets to ameliorate or create disease models. The ideal candidate will apply a combination of his or her expertise in the etiology and treatment of ALS, Parkinson’s and Alzheimer’s disease, results from our cell-based screens, and animal studies you will lead to best apply gene networks to guide our drug discovery efforts. With knowledge of neuropharmacology and experience translating compound discoveries to CNS applications, this position offers the opportunity to help lead the neurobiology research program at an emerging biotech company.


Link: https://jobs.lever.co/vergegenomics/3466c961-e166-4658-8a62-0bb99545795e
Employer: Verge Genomics
Location: Ann Arbor, MI
Sector: Industry
Degree required: PhD
Conditions: ALS
Job posted: May 2nd, 2017
Verge GenomicsAnn Arbor, MIPhDALSMay 02, 2017
Director/Sr. Director, Neurodegeneration and Repair Research

Director/Sr. Director, Neurodegeneration and Repair Research

(Click title to open job details in a new window.)
Description:

We are looking for a talented leader to direct preclinical research in Dementia and Memory Disorders within the new Neurodegeneration and Repair Research Unit. In close partnership with the early clinical lead for within the same unit, the successful candidate will be responsible for delivering innovative drug candidates for proof-of-concept trials in AD, FTD and other memory disorders. He/she will lead the efforts of multiple research teams from early target discovery to late preclinical development and support the clinical trial strategy. We seek a candidate with knowledge of the biology of neurodegeneration and an outstanding track record in the field of drug development. He/she will succeed by collaborating closely with other Biogen scientists and clinicians in the areas of neurodegeneration, neuroimmunology and repair, as well as experts in the multiple therapeutic modalities – small molecules, antibodies, biologics, antisense oligonucleotides and gene therapy – in the Biogen portfolio. An innovative approach to biomarker and drug delivery strategies will also be required. We particularly seek candidates who have demonstrated strong scientific rigor while exploring novel pathways and mechanisms in humans and model systems and in leading multidisciplinary research teams. Demonstrated expertise in Alzheimer’s research and experimental models would be an advantage but is not required.


Link: https://jobs.biogen.com/job/Cambridge-DirectorSr_Director%2C-Neurodegeneration-and-Repair-Research-MA-02138/374546100/
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: PhD or PhD/MD
Conditions: FTD
Job posted: May 2nd, 2017
BiogenCambridge, MAPhD or PhD/MDFTDMay 02, 2017

Non-Profit and Government

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
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