Figure 1B Amplitude of low frequency fluctuation  (ALFF) differences between ALS and control groups without grey matter (GM) correction (A) and with GM correction (B).
Image credit: Luo, 2012 under CC BY license



PRO-ACT LogoThe Pooled Resource Open-Access ALS Clinical Trials Database (PRO-ACT) houses the largest dataset of ALS clinical trials ever created. It was established by Prize4Life in partnership with the Northeast ALS Consortium (NEALS) and the Neurological Clinical Research Institute (NCRI) at Massachusetts General Hospital, with funding from the ALS Therapy Alliance.

PRO-ACT provides users with easy access to:

  • Over 10,700 fully de-identified clinical patient records
  • Placebo and treatment-arm data from 23 Phase II/III clinical trials
  • Demographic, lab, medical and family history, and other data elements
  • More than 10 million longitudinally collected data points

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