Researchers Identify Genetic Region That Influences the Age of ALS Onset

In a study published online in Neurobiology of Aging on September 7, the International Consortium on Amyotrophic Lateral Sclerosis Genetics (ALSGEN) reported the results of a meta-analysis of genome-wide association studies that included 4,243 people with ALS and 5,112 control individuals from 13 European ancestry cohorts. ALSGEN identified eight genomic regions that were statistically associated with ALS. Of these eight, six of these regions showed association with the age of ALS onset. The strongest locus associated with age of onset was found on chromosome 1 at SNP rs3011225. Individuals with this SNP developed ALS two and a half years earlier than people who did not have this SNP. These findings may provide important clues for understanding ALS progression. Read more about the study here.

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