Researchers at St. Jude Children’s Research Hospital and the University of Colorado, Boulder may now have a better understanding of how mutations in VCP cause ALS. The findings, which were published in Cell, showed that VCP is important for the disassembly and clearance of RNA granules. In the case of VCP mutations, these RNA granules may not be cleared as quickly, leading to the accumulation of granules in neurons and ultimately cell death. Many recent papers have presented further evidence for the role of RNA binding proteins (i.e., TDP-43, FUS, as well as the recently identified hnRNPA1 and hnRNPA2B1) and RNA granules in neuronal cell death. Looks like RNA granules could be the next hot target in ALS. Click here to read more.
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