Scientists Treat Parkinson’s in Mouse Model by Bypassing the Blood-Brain Barrier

By repurposing an established medical procedure called nasal mucosal grafting, researchers are creating new ways to deliver drugs to the brain, without the hindrance of the blood-brain barrier. As published in the Sep 8 Neurosurgery online, scientists at Massachusetts Eye and Ear Infirmary/Harvard Medical School and Boston University used this approach to administer glial-derived neurotrophic factor (GDNF) through a mucosal graft in the skull of Parkinson’s disease mouse models. Benjamin Bleier and colleagues found that this mode of administration was equivalent to direct drug administration into the brain and progression of PD was attenuated in the treated mice, and. Such a technique could provide a means to administer therapies for a multitude of neurological and psychiatric conditions.

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Reference:

Bleier BS, Kohman RE, Guerra K, Nocera AL, Ramanlal S, Kocharyan AH, Curry WT, Han X. Heterotopic Mucosal Grafting Enables the Delivery of Therapeutic Neuropeptides Across the Blood Brain Barrier. Neurosurgery. 2015 Sep 8. [Pubmed].

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BBB disease-pd gdnf topic-newmethods topic-preclinical
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