SF0034

Drug Name: SF0034
Company: SciFluor
Location: US-Massachusetts
Website: http://scifluor.com/our-approach/our-approach-fluoro.php
Drug Type: Small Molecule
Conditions: ALS, Epilepsy, Tinnitus
Mechanism Type: Neuronal hyperexcitability – Retigabine derivative
Mechanism: SF0034 is a KCNQ2/3-specific channel activator that aims to reduce neuronal hyperexcitability by enabling neurons to return to the resting state upon firing. The drug is a fluorinated-derivative of the FDA-approved epilepsy drug retigabine.
U.S. Status for ALS: Preclinical

References:
[1] Potent KCNQ2/3-Specific Channel Activator Suppresses In Vivo Epileptic Activity and Prevents the Development of Tinnitus Kalappa, BI et al. Journal of Neuroscience. 10 June 2015, 35 (23) 8829-8842.

Last updated March 8th, 2017

Share this:
Facebooktwittergoogle_plusmailFacebooktwittergoogle_plusmail