Several studies have suggested a link between traumatic brain injury (TBI) and neurodegenerative disease, including a correlation between a single TBI and Alzheimer’s disease. Evidence also exists for an increased predisposition to ALS among athletes who have suffered repeated blows to the head (see Sept 2012 news; Nov 2012 news; Oct 2014 news). In the June 22 eNeuro online, Clive Svendsen and colleaguesfrom the Cedar Sinai Medical Center in Los Angeles, California report that a single TBI was not sufficient the hasten the onset or progression of ALS in a transgenic rat model of the ALS. In light of these findings, understanding the difference between an acute versus repeated head trauma may help understand if and how TBI can contribute to the development of ALS.
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Thomsen, GM, Vit J-P, Lamb A, Gowing G, Shelest O, Alkaslasi M, Ley E, Svendsen CN. Acute traumatic brain injury does not exacerbate ALS in the SOD1G93A rat model. eNeuro 2015; 10.1523/ENEURO.0059-14.2015.[Pubmed]