Drug Name: Talampanel
Company: Teva Pharmaceutical Industries
Location: Israel
Website: http://www.tevapharm.com
Drug Type: Small Molecule
Conditions: ALS
Mechanism Type: Glutamate Excitotoxicity Blocker
Mechanism: Talampanel is a selective non-competitive antagonist of AMPA receptors, a type of glutamate receptor. Talampanel was tested as a drug to reduce neuronal death due to glutamate excitotoxicity.
U.S. Status for ALS: Discontinued

[1] Talampanel for Amyotrophic Lateral Sclerosis (ALS). ClinicalTrials.gov, 20 Oct 2011. Accessed 11 Mar 2016 from https://clinicaltrials.gov/ct2/show/NCT00696332.
[2] A phase II trial of talampanel in subjects with amyotrophic lateral sclerosis. Pascuzzi, RM et al. Amyotroph Lateral Scler. 2010 May 3;11(3):266-71.

Last updated March 11th, 2019

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