Researchers at the University of Central Florida’s College of Medicine recently found that when Hsp90 is damaged by a form of oxidative stress, called tyrosine nitration, the protein becomes a “cell executioner” and causes these cells to die. These findings were published in the March 19 issue of Proceedings of the National Academy of Sciences. “The concept that a protein that is normally protective and indispensable for cell survival and growth can turn into a killing machine, and just because of one specific oxidative modification, is amazing,” said Maria C. Franco, co-author of the study. This discovery may help researchers to develop future treatments for a variety of medical conditions including ALS, stroke, cancer, spinal cord injuries, and more.
Read more about this interesting discovery here.