A funded postdoctoral fellowship positions is available in the Kukar Lab at Emory University in the Department of Pharmacology and Chemical Biology and the Center for Neurodegenerative Diseases. The Kukar lab uses a multi-disciplinary approach spanning molecular neuroscience, chemical biology, biochemistry, bioinformatics, iPSCs, and mouse models to investigate the mechanisms of neurodegeneration. A major focus is to study how autophagy/lysosome dysfunction and neuroinflammation interact to cause Frontotemporal Dementia or Alzheimer’s disease.
This project builds upon our recent paper (Holler et al, eNeuro, 2017) to understand how decreases in the Progranulin protein causes lysosome dysfunction and ultimately neurodegeneration. Major goals are to 1) investigate the molecular mechanisms of lysosomal dysfunction and inflammation caused by GRN mutations and 2) use gene therapy approaches (Adeno-Associated Virus) to test a novel therapeutic approach to treat FTD caused by GRN mutations.
Employer: Emory University
Location: Atlanta, GA
Degree required: PhD
Job posted: February 23rd, 2019