A postdoctoral position is available in the NCI/R35 funded laboratory of Dr. Marcus E. Peter to study the role of toxic RNAs in health and disease. Projects are based on the recent discovery by the Peter Lab of a kill code embedded in the genome of multicellular organisms. This kill switch is based on RNA interference and can be engaged to kill cancer cells. However, it may also determine cell fate in multiple neurodegenerative diseases, such as Huntington’s disease (HD) and Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS).
The position is to investigate the inverse relationship between neurodegenerative diseases such as AD and HD and cancer. It will entail working with cell lines and mouse models of AD, HD and cancer. We have evidence that toxic small RNAs bound to the RNA induced silencing complex (RISC) suppress cancer and at the same time cause loss of neurons resulting in neurogedenerative diseases. The work will also involve advanced biochemistry such as pull down of Ago proteins and quantifying bound small RNAs using RNA Seq.
Employer: Northwestern University School of Medicine
Location: Chicago, IL
Degree required: PhD
Conditions: NDG, Cancer
Job posted: February 14th, 2019