Figure 7. Immunofluorescence staining of the lumbar spinal cord section of SOD1G93A transgenic mouse transplanted with F3.Olig2-Shh cells.
Image credit: Lee, et.al. 2014 under CC BY license

Job Opportunities

This free job bulletin board aims to help scientists identify job opportunities in the field of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Positions described as broadly spanning neurodegenerative diseases (NDG) are noted as ‘NDG‘. The job listing includes research positions at all levels, as well as non-research positions for which a research background at the MS, PhD, or MD level is required.

To submit any new job opportunities for this list, please email [email protected]. List the employer, location, closing date if applicable, and a link to more information. Jobs are removed after 3 months, unless requested otherwise.


Click the title of any table column to sort.

Academia

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
Assistant Professor, Cognitive Neurology

Assistant Professor, Cognitive Neurology

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Description:

The Penn State Department of Neurology is seeking an exceptional candidate to fill a tenure-track Assistant Professor of Neurology position beginning on or after June 1, 2019, depending on the availability of the selected applicant. The selected candidate must have earned a doctoral level degree and training in cognitive psychology or a related discipline with a minimum of five years of post-doctoral experience. The candidate must have a focus on and expertise in developing novel methods for early detection of cognitive changes in both healthy aging and neurodegenerative disorders; understanding underlying disease mechanisms; and linking novel, multimodal brain imaging marker(s) of healthy and neurodegenerative disorders to cognitive metrics.


Link: https://neurojobs.sfn.org/jobs/12376307/neurology-cognitive-assistant-professor
Employer: Penn State College of Medicine
Location: Hershey, PA
Sector: Academia
Degree required: PhD or MD
Conditions: NDG
Job posted: May 29th, 2019
Penn State College of MedicineHershey, PAPhD or MDNDGMay 29, 2019
Postdoctoral Fellow, Bosco Lab

Postdoctoral Fellow, Bosco Lab

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Description:

The Bosco laboratory at the University of Massachusetts Medical Center has an open position for a post-doctoral fellow. Our laboratory is highly interdisciplinary and collaborative. We are located in the state-of-the-art Albert Sherman Center for translational science at the University Campus in Worcester, MA. Our research focuses on molecular mechanisms underlying neurodegeneration, with a focus on impaired stress response in models of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and traumatic brain injury (TBI) (www.boscolab.com). The open project entails in vivo (mouse) work, cutting-edge fluorescence microcopy analyses including 2-photon and confocal microscopy, and deep sequencing.





The candidate should have a PhD in the biological sciences and extensive experience working with mice. Prior experience with mouse neuroanatomy is advantageous. Post-doctoral fellows are encouraged to secure their own funding and will be mentored in grant writing.


To apply, please send names of three references along with your cover letter and CV to [email protected]





Link: https://careers-umms.icims.com/jobs/32973/post-doctoral-associate/job
Employer: University of Massachusetts Medical School
Location: Worcester, MA
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: May 18th, 2019
University of Massachusetts Medical SchoolWorcester, MAPhDALSMay 18, 2019
Postdoctoral Fellow, Disney Lab

Postdoctoral Fellow, Disney Lab

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Description:

Multiple positions in RNA chemical biology are available in the Disney group in the Department of Chemistry at The Scripps Research Institute (www.disneylaboratory.org). In particular, we seek postdoctoral students to study the toxicity associated with inherited amyotrophic lateral sclerosis (ALS) and develop targeted RNAdegradation tools and related technologies. We are committed to each individual’s development to achieve their short term and long-term career goals.


An overview of the laboratory’s efforts in small molecule targeting of RNA for chemical probe and lead medicine development is Journal of the American Chemical Society (2019) 141(17):6776-6790. Additional information can be found at the group’s website: www.disneylaboratory.org.


Successful candidates will have a proven track record of publishing in high impact journals, experience in nucleic acids, medicinal chemistry, or chemical biology, and can work successfully as part of an interdisciplinary team. Expertise in RNA-seq data analysis is also highly desirable.


Applicants should send their CV and have three letters of reference sent to Prof. Matthew Disney at [email protected].


Link: https://www.nature.com/naturecareers/job/multiple-positions-in-rna-chemical-biology-the-scripps-research-institute-tsri-688325#apply
Employer: Scripps Research Institute
Location: Jupiter, FL
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: May 17th, 2019
Scripps Research InstituteJupiter, FLPhDALSMay 17, 2019
Research Scientist, Fraenkel Lab

Research Scientist, Fraenkel Lab

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Description:

The Fraenkel lab is seeking a research scientist to help lead studies of Huntington’s disease as well as other neurodegenerative disorders.  The Fraenkel Lab is using omic measurements and computational modeling to reveal the molecular mechanisms behind neurodegenerative diseases, to identify novel potential therapeutic strategies, and to test these strategies in vitro and in vivo.  The researcher will focus on generating omic data and will interact with in-house computational experts to generate new hypotheses regarding the mechanisms of disease, and design experimental tests of the hypotheses that emerge from this modeling. Laboratory work will include transcriptional and epigenomic assays, cell sorting-based experiments, and functional assays on mouse models and in-vitro cell models.


Link: https://jobs.sciencecareers.org/job/499174/research-scientist-in-neurodegeneration/
Employer: MIT
Location: Cambridge, MA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 17th, 2019
MITCambridge, MAPhDNDGMay 17, 2019
Research Specialist, McMillan Lab

Research Specialist, McMillan Lab

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Description:

A full-time position is available in the laboratory of Dr. Corey McMillan in the Department of Neurology at the University of Pennsylvania. This laboratory focuses on translational neuroscience questions related to improving the diagnostic and prognostic biomarkers of related neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). We also explore genotype and phenotype relationships using a multimodal approach that integrates clinical, imaging, genetic, and biofluid datasets. Applicant responsibilities will include collection of psychometric and imaging data from patients with ALS and/or FTD, preliminary statistical analyses, database management, processing biofluid samples, and administrative coordination with consortia collaborators.


Link: https://main.hercjobs.org/jobs/12333598/research-specialist-a
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required:
Conditions: ALS, FTD
Job posted: May 11th, 2019
University of PennsylvaniaPhiladelphia, PAALS, FTDMay 11, 2019
Director, Neurological Disease Research

Director, Neurological Disease Research

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Description:

The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with the great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.


The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania, has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the ‘go-to’ organization for public and private partners, who want to participate in the gene therapy space. Currently, we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.


Due to significant growth, we are looking to add a Director, Neurological Disease Research to lead a translational research team on projects related to orphan diseases.


As the Director, Neurological Disease Research, you will oversee all aspects of neurological disease research at GTP. You will establish processes for mentoring and leading SRIs in translational research projects. You will supervise and manage a team of SRIs and technicians. In consultation with the Senior Director, Neurogenetics of the Orphan Disease Center and the Director of the Gene Therapy Program, you will assess the rare disease programs that are brought into GTP for scientific research.


You should have in-vivo pharmacology expertise for preclinical translational programs as well as experience in testing the efficacy of therapeutic interventions for neurodegenerative, neuroinflammatory and neurodevelopmental disorders. The successful candidate will have extensive experience with neurobehavioral endpoints in the preclinical disease models as well as expertise in identification of electrophysiology, biomarkers, and development of quantitative biomarker measures for neurological diseases.


This position offers the opportunity to interface broadly internally & externally with diverse functional areas. Joining GTP offers scientific professionals the unique opportunity of seeing their research go from bench to bedside and discoveries that could one day lead to cures.


Link: https://www.linkedin.com/jobs/view/1134664829/
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 8th, 2019
University of PennsylvaniaPhiladelphia, PAPhDNDGMay 08, 2019
Postdoctoral Fellow, Lippmann Lab

Postdoctoral Fellow, Lippmann Lab

(Click title to open job details in a new window.)
Description:

The Lippmann Lab for Neurovascular Engineering and Therapeutic Design (lippmannlab.com) is accepting applications for two postdoctoral positions.


Our lab is focused on modeling, understanding, and treating neurodegenerative diseases from the perspective of neurovascular function. We use human induced pluripotent stem cells (iPSCs), biomaterials fabrication, and engineering strategies to build representative tissue models of the blood-brain barrier (BBB) and neurovascular unit (NVU) (Lippmann et al, Nature Biotechnology, 2012; Lippmann et al, Stem Cell Reports, 2015; Faley et al, Stem Cell Reports, 2019; O’Grady et al, Biomaterials Science, 2019). We also use these iPSC differentiation techniques with genome editing and in vitro selection/directed evolution strategies to study BBB function (Lippmann et al, Scientific Reports, 2014; Stebbins et al, Biotechnology Journal, 2018; Chiou et al, JCBFM, 2018). Our work is highly interdisciplinary, spanning engineering, neuroscience, and regenerative medicine.


 The BBB serves as a critical endothelial interface for the brain and possesses a number of specialized properties, including extremely tight intercellular junctions, suppression of macrocytosis/pinocytosis, and expression of a large cohort of molecular transporters. Although many key differences in gene expression between BBB and peripheral endothelium have been identified, linking these genes to BBB-specific functions and signaling networks in health and disease remains challenging. We are designing and implementing a number of siRNA and CRISPR screens in cultured brain endothelial cells that will shed light on how the BBB phenotype is regulated, particularly with respect to molecular transporter expression and activity. We are also designing novel routes for assessing transport of specific compounds through the BBB. Likewise, we are interested in exten­ding these investigations into model organisms and across a variety of neurodegenerative disease states.


These positions are immediately available, with flexible start dates for competitive candidates. Prospective applicants should submit a CV, a list of three potential references, and a cover letter with a brief description of research achievements, interests in our research program, and how working with us will help facilitate career goals. All materials should be emailed to Dr. Ethan Lippmann ([email protected]) with the subject line “Postdoctoral position in the Lippmann lab.”


Link: https://www.nature.com/naturecareers/job?id=686577
Employer: Vanderbilt University
Location: Nashville, TN
Sector: Academia
Degree required: PhD
Conditions: NDG
Job posted: May 1st, 2019
Vanderbilt UniversityNashville, TNPhDNDGMay 01, 2019
Postdoctoral Fellow, Miller Lab

Postdoctoral Fellow, Miller Lab

(Click title to open job details in a new window.)
Description:

Timothy Miller, M.D., Ph.D., Professor of Neurology at Washington University in St. Louis, is seeking a postdoctoral researcher to join his research team and develop antisense oligonucleotide (ASO) therapeutic methodologies.


Dr. Miller invites applications from qualified candidates of all scientific backgrounds with a strong interest in translational neurodegenerative disease research. We seek candidates to carry out projects aimed at refining and augmenting these therapeutic approaches by investigating mechanisms of ASO uptake and developing methods for targeting ASOs to specific cell types.


Further, the Miller Lab specializes in understanding molecular mechanisms of ALS and Alzheimer’s pathogenesis. Candidates would be encouraged to lead additional projects in this area and identify new avenues of discovery.


The position is currently available. Candidates should apply via email to [email protected] with an updated CV, letter of motivation, and list of references.


Link: http://www.alsresearchforum.org/wp-admin/upload.php?item=19023
Employer: Washington University In St. Louis
Location: St. Louis, MO
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: April 25th, 2019
Washington University In St. LouisSt. Louis, MOPhDALSApr 25, 2019
Chair, Department of Neuroscience

Chair, Department of Neuroscience

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Description:

An Endowed professorship (Janice and Rodney Reynolds Chair in Neurobiology) has been established in the Department of Neuroscience at the University of Connecticut School of Medicine (UConn Health) to support a senior investigator with an outstanding record of accomplishments. We invite highly successful neuroscientists to apply at the Associate Professor or Full Professor rank in the tenure track. Exceptional scientists having established independent research programs in basic and/or translational neuroscience research, especially in the area of neurodegenerative diseases, neuroinflammation, vascular dementia, stroke, or pain, are particularly encouraged to apply.


Minimum qualifications include a PhD and/or MD and demonstrated accomplishments in academic performance. Applicants should currently lead excellent research programs with a history of sustained extramural funding, excellent publications and a record of successful mentorship of graduate students and post-doctoral fellows. The successful applicant will be expected to actively participate in teaching and mentoring trainees including medical and graduate students at UConn Health.


Interested candidates should apply at https://jobs.uchc.edu, search no. 2019-758 and upload their CV, cover letter and a concise statement of their research and teaching interests. Applicants should also arrange to have at least three letters of reference (on letterhead with signature) submitted to [email protected].


Link: https://neurojobs.sfn.org/jobs/12219392/endowed-chair-department-of-neuroscience
Employer: University of Connecticut
Location: Farmington, CT
Sector: Academia
Degree required: PhD and/or MD
Conditions: NDG
Job posted: April 16th, 2019
University of ConnecticutFarmington, CTPhD and/or MDNDGApr 16, 2019
Postdoctoral Fellow, Patani Lab

Postdoctoral Fellow, Patani Lab

(Click title to open job details in a new window.)
Description:

Applications are invited for a Research Fellow based in the laboratory of Dr Rickie Patani at the UCL Queen Square Institute of Neurology and the Francis Crick Institute. The lab carries out internationally competitive research into the molecular mechanisms underpinning Motor Neuron Disease (ALS), with a particular focus on deregulated RNA metabolism. The appointee will join a team of researchers working on various aspects of cellular and molecular neuropathology. Our lab has significant experience with human pluripotent stem cell (hPSC) culture, directed differentiation to clinically relevant populations of neurons and glia, and in vitro disease modelling focusing on post-transcriptional mechanisms of disease (eg, Hall et al, Cell Reports 2017; Luisier et al, Nature Comunications 2018). We work with several human induced pluripotent stem cell (hiPSC) lines carrying MND-causing mutations (including VCP, SOD1, FUS, TDP-43, C9ORF72). Through an ongoing close collaboration with Jernej Ule and Nicholas Luscombe, we use novel functional genomic methodologies to molecularly interrogate hiPSC-based in vitro models of neurodegeneration, with a particular focus on aberrant intron retention and other forms of alternative splicing. The mechanistic insights that emerge from this project will be used as a platform for drug screening to identify potentially novel therapies for ALS.


Link: https://www.myscience.org.uk/jobs/id163223-research_fellow-university_college_london
Employer: University College London
Location: London, England
Sector: Academia
Degree required: PhD
Conditions: ALS
Job posted: April 16th, 2019
University College LondonLondon, EnglandPhDALSApr 16, 2019
Senior Research Investigator, Motor Neuron Diseases

Senior Research Investigator, Motor Neuron Diseases

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Description:

The Gene Therapy Program (GTP) and Orphan Disease Center (ODC) are entering a new era of unprecedented opportunity with the great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases. Our R&D organization has a translational infrastructure that includes: technology development, specialized immunology assays operating under GLP, a Vector Core/Manufacturing unit that conducts GMP comparable work, and a large nonclinical program for animal testing under GLP including large NHP and rodent vivaria.


We are currently looking for Senior Research Investigator (SRI), Translational Research, to work in one of the several therapeutic areas we work with such as motor neuron or neurodegenerative diseases.


Link: https://www.linkedin.com/jobs/view/1173714371/
Employer: University of Pennsylvania
Location: Philadelphia, PA
Sector: Academia
Degree required: PhD
Conditions: ALS, MND
Job posted: April 16th, 2019
University of PennsylvaniaPhiladelphia, PAPhDALS, MNDApr 16, 2019

Industry

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
Associate Director, Clinical Development, ALS

Associate Director, Clinical Development, ALS

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Description:

The position of Associate Medical Director, Clinical Development sits within Pain, Neuromuscular and Rare Disease of Late Stage Clinical Development. The new Medical Director will support Amyotrophic Lateral Sclerosis (ALS). The successful candidate will demonstrate the flexibility and capability to function at a high level across multiple studies. Activities include direct responsibility for advancing high priority clinical programs through clinical study design and execution, development of biomarker strategies, as well as interpretation of data from key clinical studies. The individual who assumes this position will interact with multiple levels of management within Biogen, external stakeholders in the medical community as well with global regulatory authorities.


The Associate Medical Director has the following responsibilities:

• Provide medical and strategic leadership for programs that integrate the individual’s extensive knowledge in basic and clinical science, neurology, and input from the medical community around the world.

• Integrate the scientific rationale, regulatory requirements, product development plan, and commercial goals to build a solid strategic framework for the Clinical Development Plan (CDP).

• Contribute to clinical study development, medical monitoring, and data interpretation.


Link: https://sjobs.brassring.com/TGnewUI/Search/home/HomeWithPreLoad?PageType=JobDetails&partnerid=169&siteid=5140&jobId=824570#jobDetails=824570_5140
Employer: Biogen
Location: Cambridge, MA
Sector: Industry
Degree required: MD, PhD or PharmD
Conditions: ALS
Job posted: May 7th, 2019
BiogenCambridge, MAMD, PhD or PharmDALSMay 07, 2019

Non-Profit and Government

Job TitleEmployerLocationDegreeConditionsDate Posted ▾
Scientific Portfolio Director

Scientific Portfolio Director

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Description:

A Scientific Portfolio Director (SPD) is an experienced professional with the ability to work for a dynamic, fast-paced organization. The SPD directs a portfolio of mechanistic and translational research awards in neuromuscular disease areas including the muscular dystrophies; motor neuron diseases; and neuromuscular junction disorders, inherited peripheral nerve disorders; congenital, metabolic and inflammatory myopathies, and channelopathies. This person will identify and address key research needs and initiate and implement high-impact research and scientific opportunities in neuromuscular diseases and demonstrate the effectiveness and impact of MDA’s research activities for patients, families, donors, and the professional communities MDA serves.  Additionally, this person will provide leadership for MDA through interactions with federal agencies, international neuromuscular disease partners, drug development groups and pharma, as well as with patient advocacy groups and other neuromuscular disease stakeholders while meeting our core standards of excellence. The SPD reports to the Senior Vice President- Scientific Program Director and works closely with MDA’s Advocacy, Health Care Services, Medical Education and Healthcare Partnership teams to further leverage MDA’s clinical and research programs and infrastructure to accelerate therapy development for neuromuscular diseases.


Link: https://mda.jobs.net/en-US/job/scientific-portfolio-director/J3V17T74NT7NGJ3CGS6
Employer: Muscular Dystrophy Association
Location: Remote
Sector: Non-Profit
Degree required: PhD
Conditions: NDG
Job posted: April 11th, 2019
Muscular Dystrophy AssociationRemotePhDNDGApr 11, 2019

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